Systems and methods for treating aneurysms

Abstract

To provide an improved system and method for treating aneurysms.SOLUTION: A system and method can be used to treat an aneurysm in a blood vessel. The system and method can use a catheter. The catheter includes a tube, a wire disposed within the tube, and an occlusion element. The occlusion element is disposed on the wire. The occlusion element is configured to fit within the tube and slide out of an opening at distal end of the tube in response to movement of the wire within the tube. The occlusion element is configured to expand to have a radius greater than a radius of the tube and cover a neck portion of the aneurysm.SELECTED DRAWING: Figure 3D

Description

Technical Field

[0001] Cross - Reference to Related Applications This application claims the priority and benefit of U.S. Patent Application No. 62 / 120,456, filed on February 25, 2015, which is hereby incorporated by reference in its entirety.

Background Art

[0002] An aneurysm is an abnormal bulge that often weakens the arteries of blood vessels and can have many complications. The bulge in the blood vessel can rupture or exert pressure on surrounding tissues. In the brain, this can cause various side effects such as visual impairment, speech impairment, balance disorder, etc. Furthermore, an aneurysm forms a space not along the main flow path of the blood flowing through the blood vessel. Therefore, this location can function as a place where blood stagnates, and due to the vortex flow, thromboembolism can form. When an aneurysm ruptures, internal bleeding can occur.

[0003] An aneurysm can be treated by open surgery from the outside. The procedure usually includes the step of partitioning the entrance, that is, the "neck" of the aneurysm, with a device such as a vascular clamp or a ligature thread. However, such a reconstructive surgical procedure can be very invasive and can cause trauma to adjacent tissues and other side effects.

[0004] An aneurysm can also be treated by an endovascular procedure. In one procedure, a separable length of wire (e.g., a coil) is inserted into the internal space of the aneurysm using a catheter. It is intended to fill the internal space of the aneurysm by the coil to reduce the blood flow to the aneurysm, causing the blood flow to stagnate and promoting the coagulation of the aneurysm. In the case of a large cerebral aneurysm, multiple ​​​​​​​​​​​Inducing a mass effect by filling the aneurysm with a coil, thereby causing brain swelling and can independently cause new symptoms. In another procedure, for aneurysms with a relatively large neck an additional stent is used to assist the holding force of the coil within the aneurysm. This approach requires additional anticoagulants and thus cannot be used when treating ruptured aneurysms. In another procedure, a temporarily inflated balloon within the blood vessel holds the coil within the internal space of the aneurysm. Once the coil is fixed, the balloon is deflated and removed. In yet another procedure, a stent device is placed within the artery to facilitate blood flow past the aneurysm. This stagnates the blood flow within the aneurysm and forms a thrombus within the aneurysm space. However, the aortic branches where the stent device is placed can be trapped or "constrained" as they interfere with access to the branches. In other cases, the branches can clump together, resulting in a stroke. Additionally, this procedure generally requires the use of additional anticoagulants, which limits the use of the device in the treatment of ruptured aneurysms. Stent devices are generally formed with a relatively fine weave. Since it diverts blood flow to the side, the fine weave increases the effect of the stent device but obstructs or interferes with access to the aneurysm space or the constrained artery. If the aneurysm does not clump, the aneurysm is occluded by the stent device, making it impossible to place an embolization device within the aneurysm. Additional procedures such as placing additional stents or open surgery may be necessary to treat the sequelae. All procedures involving the step of packing the aneurysm space suffer from several common drawbacks and can independently cause new symptoms. In another procedure, for aneurysms with a relatively large neck an additional stent is used to assist the holding force of the coil within the aneurysm. This approach requires additional anticoagulants and thus cannot be used when treating ruptured aneurysms. In another procedure, a temporarily inflated balloon within the blood vessel holds the coil within the internal space of the aneurysm. Once the coil is fixed, the balloon is deflated and removed. In yet another procedure, a stent device is placed within the artery to facilitate blood flow past the aneurysm. This stagnates the blood flow within the aneurysm and forms a thrombus within the aneurysm space. However, the aortic branches where the stent device is placed can be trapped or "constrained" as they interfere with access to the branches. In other cases, the branches can clump together, resulting in a stroke. Additionally, this procedure generally requires the use of additional anticoagulants, which limits the use of the device in the treatment of ruptured aneurysms. Stent devices are generally formed with a relatively fine weave. Since it diverts blood flow to the side, the fine weave increases the effect of the stent device but obstructs or interferes with access to the aneurysm space or the constrained artery. If the aneurysm does not clump, the aneurysm is occluded by the stent device, making it impossible to place an embolization device within the aneurysm. Additional procedures such as placing additional stents or open surgery may be necessary to treat the sequelae. and can independently cause new symptoms. In another procedure, for aneurysms with a relatively large neck an additional stent is used to assist the holding force of the coil within the aneurysm. This approach requires additional anticoagulants and thus cannot be used when treating ruptured aneurysms. In another procedure, a temporarily inflated balloon within the blood vessel holds the coil within the internal space of the aneurysm. Once the coil is fixed, the balloon is deflated and removed. In yet another procedure, a stent device is placed within the artery to facilitate blood flow past the aneurysm. This stagnates the blood flow within the aneurysm and forms a thrombus within the aneurysm space. However, the aortic branches where the stent device is placed

[0005] All procedures involving the step of packing the aneurysm space suffer from several common drawbacks This will become necessary. First, a large number of coil wires are required to fill the aneurysm space, and this takes time and increases the time until the procedure is completed. Furthermore, since the coil can shrink over time, it will occupy a smaller percentage of the total volume of the aneurysm. Compressing the coil sufficiently raises concerns about aneurysm recurrence and may require further treatment. SUMMARY OF THE INVENTION PROBLEMS TO BE SOLVED BY THE INVENTION

[0006] It would be beneficial to provide an improved system and method for treating aneurysms. MEANS FOR SOLVING THE PROBLEM

[0007] One embodiment relates to a catheter for treating an aneurysm in a blood vessel. The catheter includes a tube, a wire disposed within the tube, and an occlusion element. The occlusion element is disposed over the wire. The occlusion element is configured to fit within the tube and slide out of the opening at the distal end of the tube in response to movement of the wire within the tube. The occlusion element is configured to expand to have a radius larger than the radius of the tube and cover the neck portion of the aneurysm.

[0008] One embodiment relates to a method for treating an aneurysm in a blood vessel. The method includes providing a distal portion of a tube to a neck region of the aneurysm and sliding a wire connected to an occlusion element within the tube such that the occlusion element exits the tube in the neck region. The method also includes separating the occlusion element from the wire after the occlusion element has exited the tube. ​

[0009] One embodiment relates to an occlusion system for treating an aneurysm of a blood vessel. The occlusion sys tem includes a wire and an occlusion element disposed on the wire. The occlusion element is circular ly compressed into a frustoconical shape and configured to expand into a disk or concave shape to cover the neck portion of the aneurysm.

[0010] The present invention is capable of other embodiments and can be implemented in various ways. Alternative exemplary embodiments related to other features and combinations of features may generally be recited in the claims.

[0011] These and other features, aspects, and advantages of the present invention will become apparent from the following description, the scope of the appended claims, and the following exemplary embodiments shown in the drawings described briefly below. BRIEF DESCRIPTION OF THE DRAWINGS

[0012]

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[0013] Generally referring to FIGS. 1 - 14, an aneurysm occlusion device configured to treat an aneurysm 10 according to several exemplary embodiments is illustrated. The aneurysm 10 is a bulge of a wall 13 extending outside the blood vessel 12 and has an internal space 14 that is in fluid communication with the blood vessel 12 through an opening of a neck portion 16. The aneurysm 10 can occur as a part of the blood vessel 12, and its wall 13 is weakened by disease or trauma. In one embodiment, the aneurysm 10 can be located along an artery such as an artery in the skull (e.g., basilar artery, middle cerebral artery, etc.). The aneurysm 10 shown in the figures is for illustrative purposes only, and it will be understood that the occlusion device described herein can be used to treat aneurysms of various sizes and locations. For example, the aneurysm 10 can be located between two branches of a blood vessel. Referring to FIGS. 1 - 3E, an occlusion device 20 according to one exemplary embodiment is shown disposed at the neck portion 16 of the aneurysm 10 to illustrate the flow of blood between the blood vessel 12 and the internal space 14 of the aneurysm. The aneurysm 10 can occur as a part of the blood vessel 12, and its wall 13 is weakened by disease or trauma. In one embodiment, the aneurysm 10 can be located along an artery such as an artery in the skull (e.g., basilar artery, middle cerebral artery, etc.). The aneurysm 10 shown in the figures is for illustrative purposes only, and it will be understood that the occlusion device described herein can be used to treat aneurysms of various sizes and locations. For example, the aneurysm 10 can be located between two branches of a blood vessel. The aneurysm 10 can occur as a part of the blood vessel 12, and its wall 13 is weakened by disease or trauma. In one embodiment, the aneurysm 10 can be located along an artery such as an artery in the skull (e.g., basilar artery, middle cerebral artery, etc.). The aneurysm 10 shown in the figures is for illustrative purposes only, and it will be understood that the occlusion device described herein can be used to treat aneurysms of various sizes and locations. For example, the aneurysm 10 can be located between two branches of a blood vessel. The aneurysm 10 shown in the figures is for illustrative purposes only, and it will be understood that the occlusion device described herein can be used to treat aneurysms of various sizes and locations. For example, the aneurysm 10 can be located between two branches of a blood vessel. The aneurysm 10 shown in the figures is for illustrative purposes only, and it will be understood that the occlusion device described herein can be used to treat aneurysms of various sizes and locations. For example, the aneurysm 10 can be located between two branches of a blood vessel. The aneurysm 10 shown in the figures is for illustrative purposes only, and it will be understood that the occlusion device described herein can be used to treat aneurysms of various sizes and locations. For example, the aneurysm 10 can be located between two branches of a blood vessel. The aneurysm 10 shown in the figures is for illustrative purposes only, and it will be understood that the occlusion device described herein can be used to treat aneurysms of various sizes and locations. For example, the aneurysm 10 can be located between two branches of a blood vessel.

[0014] Referring to FIGS. 1 - 3E, an occlusion device 20 according to one exemplary embodiment is shown disposed at the neck portion 16 of the aneurysm 10 to illustrate the flow of blood between the blood vessel 12 and the internal space 14 of the aneurysm. The occlusion device 20 according to one exemplary embodiment is shown disposed at the neck portion 16 of the aneurysm 10 to illustrate the flow of blood between the blood vessel 12 and the internal space 14 of the aneurysm. Since it blocks or prevents, it reduces the possibility of the aneurysm 10 rupturing. The occlusion device 20 is configured as a low-profile device to minimize interference with surrounding tissues such as the branches 18 of the blood vessel 12. The occlusion device 20 can be composed of a biodegradable or bioabsorbable material and can be configured to promote endothelialization.

[0015] The occlusion device 20 includes an internal cover 22 (e.g., a plate, a thin film, etc.) disposed within the internal space 14 of the aneurysm 10. The internal cover 22 has an outer diameter larger than the diameter of the neck portion 16. The internal cover 22 is thin, flexible, and has a concave body, which can be bent (e.g., depressed) and inserted into the internal space 14 of the aneurysm 10 through the neck portion 16 (e.g., inserted by a catheter) and opens to at least partially occlude the neck portion 16. As used herein, concave means any body formed to have a depression or cavity along one side surface. As shown in FIG. 1, in an exemplary embodiment, the internal cover 22 can generally be dome-shaped. In another embodiment, the internal cover 22 can be of another concave shape (e.g., conical shape), disposed on the neck portion 16 and opening towards the internal space 14. In one embodiment, the cover 22 can be disk-shaped.

[0016] The internal cover 22 is formed from a flexible (e.g., soft) biocompatible material, which can be folded into a microcatheter and transported intravascularly to reach the aneurysm 10. The flexibility of the internal cover 22 allows it to conform to the shape of the internal surface 15 of the aneurysm 10 and effectively impede the blood flow between the aneurysm 10 and the blood vessel 12. The internal surface 15 of the aneurysm 10 ​​​​​​​​​​​​By closely conforming to the shape of, it promotes the adhesion of the internal cover 22 to the tissue of the aneurysm 10 and also the formation of new tissue that closes the neck portion 16.

[0017] The internal cover 22 can be sized to conform to a particular aneurysm 10. As shown in FIGS. 1-2 as such, the internal cover 22 has a diameter larger than the diameter of the neck portion 16, and the peripheral portion 24 of the internal cover 22 contacts the inner surface 15 of the aneurysm 10. Due to the flexibility of the internal cover 22 , the internal cover 22 can be larger than the size of the neck portion 16 without damaging the aneurysm 10 (e.g., without causing it to rupture). For example, an internal cover with a diameter of about 5 mm can be used to occlude an aneurysm with a neck portion diameter up to 4 mm, and an internal cover with a diameter of about 8 mm can be used to occlude an aneurysm with a neck portion diameter of 4-6 mm, and an internal cover with a diameter of about 12 mm can be used to occlude an aneurysm with a neck portion diameter of 6-10 mm.

[0018] In one embodiment, the internal cover 22 can be formed from a biocompatible metal or metal alloy such as platinum, stainless steel, titanium, nickel titanium alloy (e.g., nitinol), etc. For example, the internal cover 22 can be a concave disk formed from nitinol cut into a sheet. The nitinol alloy can be configured to perform a second heat treatment to form the desired concave shape. According to an exemplary embodiment, the thickness of the internal cover 22 can be less than 100 microns and have the desired flexibility. In another embodiment, the internal cover 22 can be formed as a relatively dense mesh such as a 37 micron mesh formed of a plurality of wires or fibers bonded together (e.g., welded, soldered, braided, etc.). formed of a relatively high density mesh such as a 37 micron mesh formed of a plurality of wires or fibers bonded together (e.g., welded, soldered, braided, etc.).

[0019] In another embodiment, the inner cover 22 can be formed from a biocompatible polymer such as polytetrafluoroethylene (PTFE), modified polyurethane, silicone, or other suitable polymers. In yet another exemplary embodiment, the inner cover 22 can be formed from a metal or alloy coated with a polymer (e.g., parylene, PTFE, PFE, etc.) to increase lubricity and biocompatibility and reduce thrombus formation. The inner cover 22 can be formed as a fixed sheet or thin film, or as a relatively dense mesh. In some embodiments, the inner cover 22 can include a nylon sheet with holes laser-drilled to reduce the bulk portion and provide a matrix for endothelialization. Another embodiment can include two-photon polymerization, i.e., forming the inner cover 22 that is directly mounted on the delivery system with a three-dimensionally printed biocompatible material, or lying laterally on a framework connected to the delivery system to enable customization of the final shape of the inner cover 22 at the time of treatment. It can be formed from a biocompatible polymer such as polytetrafluoroethylene (PTFE), modified polyurethane, silicone, or other suitable polymers. In yet another exemplary embodiment, the inner cover 22 can be formed from a metal or alloy coated with a polymer (e.g., parylene, PTFE, PFE, etc.) to increase lubricity and biocompatibility and reduce thrombus formation. The inner cover 22 can be formed from a metal or alloy coated with a polymer (e.g., parylene, PTFE, PFE, etc.) to increase lubricity and biocompatibility and reduce thrombus formation. The inner cover 22 can be formed as a fixed sheet or thin film, or as a relatively dense mesh. In some embodiments, the inner cover 22 can include a nylon sheet with holes laser-drilled to reduce the bulk portion and provide a matrix for endothelialization. Another embodiment can include two-photon polymerization, i.e., forming the inner cover 22 that is directly mounted on the delivery system with a three-dimensionally printed biocompatible material, or lying laterally on a framework connected to the delivery system to enable customization of the final shape of the inner cover 22 at the time of treatment. In some embodiments, the inner cover 22 can include a nylon sheet with holes laser-drilled to reduce the bulk portion and provide a matrix for endothelialization. Another embodiment can include two-photon polymerization, i.e., forming the inner cover 22 that is directly mounted on the delivery system with a three-dimensionally printed biocompatible material, or lying laterally on a framework connected to the delivery system to enable customization of the final shape of the inner cover 22 at the time of treatment. Another embodiment can include two-photon polymerization, i.e., forming the inner cover 22 that is directly mounted on the delivery system with a three-dimensionally printed biocompatible material, or lying laterally on a framework connected to the delivery system to enable customization of the final shape of the inner cover 22 at the time of treatment. Another embodiment can include two-photon polymerization, i.e., forming the inner cover 22 that is directly mounted on the delivery system with a three-dimensionally printed biocompatible material, or lying laterally on a framework connected to the delivery system to enable customization of the final shape of the inner cover 22 at the time of treatment.

[0020] Referring to FIGS. 3A - 3D, the deployment of the inner cover 22 according to an exemplary embodiment by a catheter 30 is shown. Referring to FIG. 3A, a catheter 30 including a push wire 32 advances through the blood vessel 12 to the location of the aneurysm 10. The distal end 34 of the catheter passes through the neck portion 16 and advances into the internal space 14 of the aneurysm 10, or a portion of the blood vessel 12 near the neck portion 16. The push wire 32 is located within the lumen formed in the catheter 30. The catheter 30 can have one lumen, i.e., the push wire 32 can be located within one of several lumens formed inside the catheter 30. The inner cover 22 is attached to the push wire Referring to FIG. 3A, a catheter 30 including a push wire 32 advances through the blood vessel 12 to the location of the aneurysm 10. The distal end 34 of the catheter passes through the neck portion 16 and advances into the internal space 14 of the aneurysm 10, or a portion of the blood vessel 12 near the neck portion 16. The push wire 32 is located within the lumen formed in the catheter 30. The catheter 30 can have one lumen, i.e., the push wire 32 can be located within one of several lumens formed inside the catheter 30. The catheter 30 can have one lumen, i.e., the push wire 32 can be located within one of several lumens formed inside the catheter 30. The inner cover 22 is attached to the push wire It is coupled to the distal end 36 of the pusher wire 32 and fits into the lumen in a folded form. In the folded form, the peripheral portion 24 of the inner cover 22 is located upstream (e.g., near the distal end 34) compared to the central portion 26 to which the pusher wire 36 is coupled. Referring to FIG. 3B, the pusher wire 32 moves within the lumen with respect to the catheter 30 until the inner cover 22 begins to emerge from the end 34 of the catheter 30. The inner cover 22 expands into an extended form within the inner space 14 (e.g., by the internal spring force of the inner cover 22) so that the end 34 of the catheter 30 is defined. By holding the catheter 30 stationary and advancing the pusher wire 32 (e.g., pressing), holding the pusher wire 32 stationary and pulling the catheter 30 (e.g., withdrawing from the sheath), or a combination of movements of the catheter 30 and the pusher wire 32, the pusher wire 32 is moved with respect to the catheter 30. The inner cover 22 can be located within the blood vessel 12 or within the aneurysm 10 and partially opened at the distal end 34 of the catheter 30. In the folded state, the peripheral portion 24 of the inner cover 22 is located upstream (e.g., near the distal end 34) compared to the central portion 26 to which the pusher wire 36 is coupled. Referring to FIG. 3B, the pusher wire 32 moves within the lumen with respect to the catheter 30 until the inner cover 22 begins to emerge from the end 34 of the catheter 30. The inner cover 22 expands into an extended form within the inner space 14 (e.g., by the internal spring force of the inner cover 22) so that the end 34 of the catheter 30 is defined. By holding the catheter 30 stationary and advancing the pusher wire 32 (e.g., pressing), holding the pusher wire 32 stationary and pulling the catheter 30 (e.g., withdrawing from the sheath), or a combination of movements of the catheter 30 and the pusher wire 32, the pusher wire 32 is moved with respect to the catheter 30. The inner cover 22 can be located within the blood vessel 12 or within the aneurysm 10 and partially opened at the distal end 34 of the catheter 30. Referring to FIG. 3C, before the inner cover 22 is fully deployed from the catheter 30, the distal end 34 of the catheter 30 advances into the inner space 14 of the aneurysm 10. Referring to FIG. 3D, with the inner cover 22 fully deployed from the catheter 30, the catheter 30 and / or the pusher wire 32 are pulled until the inner cover 22 seats on the inner surface 15 of the aneurysm. Referring to FIG. 3E, the distal end 36 of the pusher wire 32 is detached from the inner cover 22, the catheter 30 and the pusher wire 32 are withdrawn from the blood vessel 12, while the inner cover 22 may remain at the neck portion 16 of the aneurysm 10. The pusher wire 32 can be any of

[0021] Referring to FIG. 3C, before the inner cover 22 is fully deployed from the catheter 30, the distal end 34 of the catheter 30 advances into the inner space 14 of the aneurysm 10. Referring to FIG. 3D, with the inner cover 22 fully deployed from the catheter 30, the catheter 30 and / or the pusher wire 32 are pulled until the inner cover 22 seats on the inner surface 15 of the aneurysm. Referring to FIG. 3E, the distal end 36 of the pusher wire 32 is detached from the inner cover 22, the catheter 30 and the pusher wire 32 are withdrawn from the blood vessel 12, while the inner cover 22 may remain at the neck portion 16 of the aneurysm 10. The pusher wire 32 can be any of Referring to FIG. 3E, the distal end 36 of the pusher wire 32 is detached from the inner cover 22, the catheter 30 and the pusher wire 32 are withdrawn from the blood vessel 12, while the inner cover 22 may remain at the neck portion 16 of the aneurysm 10. The pusher wire 32 can be any of ​It can be disconnected from the inner cover 22 by a suitable electrical or mechanical disconnect device. In one case, or the inner cover 22 can be removed by pulling the wire 32 from the cover 22 and engaging the cover 22 with the distal end of the tube 30 and removing it from the wire 32.

[0022] In one embodiment, the inner cover 32 can be configured to be biased in the direction of the open position . In another embodiment, the inner cover 32 can include a mesh supported by rib members or splines that radiate outwardly from the central portion of the inner cover 32. The rib members or splines are biased in the direction of the open position of one embodiment. In one embodiment, the rib members and splines operate in an inverted umbrella mode of operation and are locked in the fully open position once they reach the fully open position.

[0023] Referring to FIGS. 4-5, an occlusion device 120 located at the neck portion 16 of the aneurysm 10 according to an exemplary embodiment is shown, which interrupts or stops the flow of blood between the blood vessel 12 and the internal space 14 of the aneurysm, thereby reducing the likelihood of the aneurysm 10 rupturing. The occlusion device 120 is composed of a low-profile device and minimizes the impact on the surrounding human body such as the collateral branch 18 of the blood vessel 12. The occlusion device 120 can be composed of a biodegradable or bioabsorbable material and can be configured to promote endothelialization.

[0024] The occlusion device 120 includes an inner cover 122 (such as a plate, a thin film, etc.) similar to the above-described inner cover 22 disposed in the internal space 14 of the aneurysm 10. The occlusion device 120 further includes an internal anchoring member 140 disposed in the aneurysm 10. The internal The anchoring member 140 is configured to hold the inner cover 122 within the aneurysm 10 of the neck portion 16. The inner anchoring member 140 is a relatively rigid body that supports the inner cover 122, reducing the possibility that the inner cover 122 will shift from the neck portion 14 due to the fluid pressure of the blood in the blood vessel 12. According to an exemplary embodiment, the inner anchoring member 140 comprises one or more loop-shaped coils formed from a suitable biocompatible metal or alloy (e.g., platinum, stainless steel, nickel-titanium alloy, etc.). The metal coils may be similar to the coils commonly used in endovascular coiling procedures. The inner anchoring member 140 includes at least one coil that is coupled to the inner cover 122 and contacts the inner surface 15 of the aneurysm 10. The loops of the inner anchoring member 140 do not fill the entire inner space 14, i.e., they substantially fill a part of the inner space 14. Instead, the inner anchoring member 140 may include only a small number of loops. In one exemplary embodiment, the inner anchoring member 140 may include one loop coil. In another embodiment, the anchoring member 140 includes a large number of loops that substantially fill the inner space 14. The direction, number, and size of the loops of the inner anchoring member 140 may vary depending on the size and shape of the aneurysm 10.

[0025]

[0026] Referring to FIG. 5, the inner cover 122 and the inner anchoring member 140 according to an exemplary embodiment are shown disposed within the catheter 30. The inner cover 122 is coupled to the distal end 36 of the push wire 32 and is disposed within the lumen of the catheter 30 in a folded configuration. . In the folded configuration, the peripheral portion 124 of the inner cover 122 is located upstream (e.g., closer to the distal end 34) compared to the central portion 126 where the push wire 36 couples onto the first surface 144. The inner anchoring member 140 is coupled to the second surface 146 of the inner cover 122 on the opposite side of the first surface 142 and is positioned inside the lumen of the catheter 30 on the upstream side of the inner cover 122. The inner cover 122 and the inner anchoring member 130 are deployed within the aneurysm 10 in a process similar to that described with reference to FIGS. 3A - 3E. When the distal end 34 of the catheter 30 is positioned near the neck portion 16 of the aneurysm 10, the push wire 3 2 moves inside the lumen relative to the catheter 30. The movement of the push wire causes the anchoring member 40 to reach the internal space 14 and coil within the internal space. In one embodiment, the push wire 32 has a circular solid cross - section and the anchoring member 140 has a coiled cross - section (e.g., like a telephone cord) to facilitate coiling within the internal space 14. In one embodiment, the push wire 32 and the anchoring member 140 have a circular solid cross - section. In one embodiment, the push wire 32 and the anchoring member have a coiled solid cross - section. Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter.

[0027] The occlusion device 120, including the inner cover 122 and the inner anchoring member 130, is deployed within the aneurysm 10 in a process similar to that described with reference to FIGS. 3A - 3E. When the distal end 34 of the catheter 30 is positioned near the neck portion 16 of the aneurysm 10, the push wire 3 2 moves inside the lumen relative to the catheter 30. The movement of the push wire causes the anchoring member 40 to reach the internal space 14 and coil within the internal space. The inner cover 122 and the inner anchoring member 130 are deployed within the aneurysm 10 in a process similar to that described with reference to FIGS. 3A - 3E. When the distal end 34 of the catheter 30 is positioned near the neck portion 16 of the aneurysm 10, the push wire 3 2 moves inside the lumen relative to the catheter 30. The movement of the push wire causes the anchoring member 40 to reach the internal space 14 and coil within the internal space. Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter.

[0028] In one embodiment, the push wire 32 has a circular solid cross - section and the anchoring member 140 has a coiled cross - section (e.g., like a telephone cord) to facilitate coiling within the internal space 14. In one embodiment, the push wire 32 and the anchoring member 140 have a circular solid cross - section. In one embodiment, the push wire 32 and the anchoring member have a coiled solid cross - section. Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter. In one embodiment, the push wire 32 has a circular solid cross - section and the anchoring member 140 has a coiled cross - section (e.g., like a telephone cord) to facilitate coiling within the internal space 14. In one embodiment, the push wire 32 and the anchoring member 140 have a circular solid cross - section. In one embodiment, the push wire 32 and the anchoring member have a coiled solid cross - section. Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter. Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter.

[0029] Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter. Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter. Once the coiling of the anchoring member is complete, the inner anchoring member 140 is withdrawn from the catheter and remains in the internal space 14 where it contacts the inner surface 15 of the aneurysm 10. The push wire 32 remains until the inner cover 122 begins to emerge from the end 34 of the catheter. It further moves and expands into an extended form within the internal space 14. Next, the catheter 30 and / or the push wire 32 are pulled until the inner cover 122 seats on the inner surface 15 of the aneurysm 10 and is held in place by the internal anchoring member 140. The distal end 36 of the push wire 32 is detached from the first surface 146 of the inner cover 122, and the catheter 30 and the push wire 32 can be withdrawn from the blood vessel 12, but the inner cover 22 remains together with the internal anchoring member 140 that attaches to the second surface 146 at the neck portion 16 of the aneurysm 10. and / or the push wire 32 are pulled until the inner cover 122 seats on the inner surface 15 of the aneurysm 10 and is held in place by the internal anchoring member 140. The distal end 36 of the push wire 32 is detached from the first surface 146 of the inner cover 122, and the catheter 30 and the push wire 32 can be withdrawn from the blood vessel 12, but the inner cover 22 remains together with the internal anchoring member 140 that attaches to the second surface 146 at the neck portion 16 of the aneurysm 10. The distal end 36 of the push wire 32 is detached from the first surface 146 of the inner cover 122, and the catheter 30 and the push wire 32 can be withdrawn from the blood vessel 12, but the inner cover 22 remains together with the internal anchoring member 140 that attaches to the second surface 146 at the neck portion 16 of the aneurysm 10. The distal end 36 of the push wire 32 is detached from the first surface 146 of the inner cover 122, and the catheter 30 and the push wire 32 can be withdrawn from the blood vessel 12, but the inner cover 22 remains together with the internal anchoring member 140 that attaches to the second surface 146 at the neck portion 16 of the aneurysm 10. The distal end 36 of the push wire 32 is detached from the first surface 146 of the inner cover 122, and the catheter 30 and the push wire 32 can be withdrawn from the blood vessel 12, but the inner cover 22 remains together with the internal anchoring member 140 that attaches to the second surface 146 at the neck portion 16 of the aneurysm 10. The distal end 36 of the push wire 32 is detached from the first surface 146 of the inner cover 122, and the catheter 30 and the push wire 32 can be withdrawn from the blood vessel 12, but the inner cover 22 remains together with the internal anchoring member 140 that attaches to the second surface 146 at the neck portion 16 of the aneurysm 10.

[0030] Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil. Referring to FIG. 6, in one exemplary embodiment, the anchoring member 140 can have variable stiffness. For example, the internal anchoring member 140 can be relatively flexible at the proximal end 146 and relatively rigid at the distal end 148. The relatively rigid distal end 146 can be configured to reinforce and additionally support the wall of the aneurysm 10. The stiffer portion of the internal anchoring member 140 can be utilized as a structural member to form a structure within the internal space 14 of the aneurysm, and the more flexible portion can be utilized to fill the internal space of the aneurysm and support the inner cover 122. The stiffness of the internal anchoring member 140 can be controlled in various ways, such as by changing the coil thickness, the coil radius, and / or the material used to form the coil.

[0031] The more flexible portion of the internal anchoring member can include a detachable sheath or layer that aids in positioning the stiffer portion inside the anchoring member 140 within the aneurysm 10. When the stiffer portion of the internal anchoring member 140 is positioned at the distal end 148, the sheath The more flexible portion of the internal anchoring member can include a detachable sheath or layer that aids in positioning the stiffer portion inside the anchoring member 140 within the aneurysm 10. When the stiffer portion of the internal anchoring member 140 is positioned at the distal end 148, the sheath The more flexible portion of the internal anchoring member can include a detachable sheath or layer that aids in positioning the stiffer portion inside the anchoring member 140 within the aneurysm 10. When the stiffer portion of the internal anchoring member 140 is positioned at the distal end 148, the sheath can be removed.

[0032] In one embodiment, the stiffness of the internal anchoring member 140 varies smoothly or gradually along the length of the internal anchoring member 140 between the distal end 148 and the proximal end 146 and can be obtained. In other exemplary embodiments, the internal anchoring member 140 may include two or more discrete regions or portions, each portion having a different stiffness or different properties. The internal anchoring member 14 0 may include a marker or other indicia indicating a transition from one region to another . In one embodiment, the indicia may be external and may be on an external sheath that joins a push wire, and each of the external indicia corresponds to a transition from a region having a first stiffness to a region having a second stiffness. In another embodiment, the indicia may be internal and may be a radiopaque indicia (e.g., a platinum coating) on the internal anchoring member 140 between regions. In one embodiment, the anchoring member 140 with variable stiffness can be used even without the internal cover 122. In such an embodiment, the anchoring member 140 fills the internal space 14.

[0033] In one embodiment, a plurality of anchoring members 140 may be used. In one embodiment, the variable stiffness (e.g., thickness) of the first deployed anchoring member 140 is thicker than the variable stiffness (e.g., thickness) of the next deployed anchoring member. ring member.

[0034] Referring to FIGS. 7-10, an occlusion device 220 according to an exemplary embodiment is positioned at the neck portion 26 of the aneurysm 20 to block or stop the flow of blood between the blood vessel 22 shown and the internal space 24 of the aneurysm 20, thereby reducing the likelihood of rupture of the aneurysm 20. The occlusion device 220 is Composed of a rope profile device to minimize interference with surrounding tissues such as the branch 28 of the blood vessel 22 The occluding device 220 can be composed of a biodegradable or bioabsorbable material and can be configured to promote endothelialization.

[0035] The occluding device 220 includes an internal cover 222 (e.g., a plate, a thin film, etc.) disposed in the internal space 14 of the aneurysm 10 similar to the above-described internal cover 22, and an internal anchoring member 240 disposed inside the aneurysm 10 similar to the above-described internal anchoring member 140. The internal anchoring member 240 is configured to stop the internal cover 222 inside the aneurysm 20 at the neck portion 16. The occluding device 220 further includes an external anchoring member 250 disposed in the blood vessel 12 near the aneurysm 10. The external anchoring member 250 is a relatively rigid body that supports the internal cover 222 and reduces the possibility that the internal cover 222 is displaced from the neck portion 14 by the fluid pressure of the blood in the blood vessel 12.

[0036] Referring to FIG. 7, the external anchoring member 250 according to the exemplary embodiment includes a loop 252 of a coil formed from a suitable biocompatible metal or alloy (e.g., platinum, stainless steel, nickel-titanium alloy, etc.). The metal coil can be similar to the coil usually used in an endovascular coiling procedure. In one embodiment, the loop 252 is coupled to the internal cover 222 and contacts the wall 13 of the blood vessel 12. In one embodiment, the loop 252 is positioned perpendicular to the flow of blood passing through the blood vessel 12. In one embodiment, a plurality of coils or loops 252 can be used.

[0037] ​​​​​​​​​​​​​Referring to FIG. 8, the external anchoring member 250 according to the exemplary embodiment includes a first loop 2 54 and a second loop 256. The loops 254 and 256 can be loops of a coil formed from a suitable biocompatible metal or alloy (e.g., platinum, stainless steel, nickel titanium alloy, etc.). At least one of the loops 254 and 256 is coupled to the inner cover 22 2 and contacts the wall 13 of the blood vessel 12. The first loop 254 extends around the inner circumference of the blood vessel 12 so as to be perpendicular to the flow of blood passing through the blood vessel 12. The second loop 256 is parallel to the flow of blood passing through the blood vessel 12. The second loop 256 is formed from a coil with a very small diameter and does not substantially obstruct the flow of blood passing through the blood vessel. In other embodiments, the external anchoring member 250 can include three or more loops. The direction, number, and size of the loops can vary depending on the size and shape of the blood vessel 12. 12. The second loop 256 is formed from a coil with a very small diameter and does not substantially obstruct the flow of blood passing through the blood vessel. In other embodiments, the external anchoring member 250 can include three or more loops. The direction, number, and size of the loops can vary depending on the size and shape of the blood vessel 12. The direction, number, and size of the loops can vary depending on the size and shape of the blood vessel 12.

[0038] Referring to FIG. 9, in another exemplary embodiment, the external anchoring member 250 includes a stent 258 formed from a suitable biocompatible metal or alloy (e.g., platinum, stainless steel, nickel titanium alloy, etc. or a suitable biocompatible polymer). The stent 258 is guided by the catheter 30 to the blood vessel 12 close to the aneurysm 10 in a folded state. Once deployed inside the blood vessel 12, the stent 258 expands to press against the wall of the blood vessel 12. The stent 258 can be self-expanding or expandable by any other device such as an inflatable balloon. All or part of the stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258). ) or a suitable biocompatible polymer). The stent 258 is guided by the catheter 30 to the blood vessel 12 close to the aneurysm 10 in a folded state. Once deployed inside the blood vessel 12, the stent 258 expands to press against the wall of the blood vessel 12. The stent 258 can be self-expanding or expandable by any other device such as an inflatable balloon. All or part of the stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258). is guided by the catheter 30 to the blood vessel 12 close to the aneurysm 10 in a folded state. Once deployed inside the blood vessel 12, the stent 258 expands to press against the wall of the blood vessel 12. The stent 258 can be self-expanding or expandable by any other device such as an inflatable balloon. All or part of the stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258). Once deployed inside the blood vessel 12, the stent 258 expands to press against the wall of the blood vessel 12. The stent 258 can be self-expanding or expandable by any other device such as an inflatable balloon. All or part of the stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258). Once deployed inside the blood vessel 12, the stent 258 expands to press against the wall of the blood vessel 12. The stent 258 can be self-expanding or expandable by any other device such as an inflatable balloon. All or part of the stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258). or an inflatable balloon. All or part of the stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258). The stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258). The stent 258 can be coated or covered with a radio-opaque material such as platinum, etc., so that the stent 258 can be visualized (e.g., during or after the placement of the stent 258).

[0039] The stent 258 is not intended to occlude the neck portion 16 of the aneurysm 10, and forms a structure that assists in the placement and anchoring of the inner cover 2 22. Thus, the stent 258 need not be the same width as, or wider than, the neck portion 16, but may have a relatively short body (e.g., shorter than the width of the neck portion 16 of the aneurysm 10). By having a relatively short length, the external anchoring member 250 reduces the possibility of rupturing the surrounding tissue, such as the side branches 18 of the blood vessel 1 2. Further, the stent 258 may be of a relatively open configuration that is non-dense and has a variable cell form, and may extend proximally from the neck portion 16 into the blood vessel 1 2. In other embodiments, the stent 258 may be a solid member such as a relatively thin band formed from a metal or alloy.

[0040] In another embodiment, the external anchoring member 250 may be a temporary member that is removed with the catheter 30 after the occlusion device 320 is placed at the neck portion 16 of the aneurysm and attached to the wall of the aneurysm 10. For example, the external anchoring member may be a balloon that inflates with air within the blood vessel 12 near the aneurysm, and provides a temporary structure to support the inner cover 222.

[0041] Referring to FIG. 10, the inner cover 222, the inner anchoring member 2 40, and the external anchoring member 250 according to the exemplary embodiment are shown disposed within the catheter 30. The external anchoring member 250 is coupled to the distal end 36 of the push wire 32 and is covered within the lumen of the catheter 30 in a folded configuration. The external anchoring member 250 is disposed within the inner cover - It is coupled to - 222 and, in the folded form, is covered within the lumen of the catheter 30 upstream of the external anchoring member 250. The external anchoring member 250 can be adhesively coupled to the inner cover 222, for example. In the folded form, the peripheral portion 224 of the inner cover 222 is located upstream of the central portion 226, to which the external anchoring member 250 is coupled on the first surface 244. The internal anchoring member 240 is coupled to the second surface 246 of the inner cover 222 facing the first surface 242 and is disposed within the lumen of the catheter 30 upstream of the inner cover 222. In the folded form, the peripheral portion 224 of the inner cover 222 is located upstream of the central portion 226, to which the external anchoring member 250 is coupled on the first surface 244. The internal anchoring member 240 is coupled to the second surface 246 of the inner cover 222 facing the first surface 242 and is disposed within the lumen of the catheter 30 upstream of the inner cover 222. In the folded form, the peripheral portion 224 of the inner cover 222 is located upstream of the central portion 226, to which the external anchoring member 250 is coupled on the first surface 244. The internal anchoring member 240 is coupled to the second surface 246 of the inner cover 222 facing the first surface 242 and is disposed within the lumen of the catheter 30 upstream of the inner cover 222.

[0042] The occlusion device 220 including the inner cover 222 and the internal anchoring member 230 is deployed within the aneurysm 20 in the same manner as the process described above with reference to FIGS. 3A - 3E. When the distal end 34 of the catheter 30 is located near the neck portion 26 of the aneurysm 20, the push wire 32 moves within the lumen relative to the catheter 30. The internal anchoring member 240 is pushed out of the catheter and moves into the internal space 24, where it contacts the inner surface 25 of the aneurysm 20. The push wire 32 moves further until the inner cover 222 begins to emerge from the end 34 of the catheter 30 and expands to an expanded form within the internal space 24. Next, the catheter 3 0 and / or the push wire 32 are pulled until the inner cover 222 seats on the inner surface 25 of the aneurysm 20 and is held in place by the internal anchoring member 240. The push wire 32 moves further until the external anchoring member 250 emerges from the catheter 30. The external anchoring member 250 can be, for example, one or more loops 252, 254, or 256, or a stent 258. The distal end of the push wire 32 moves further until the external anchoring member 250 emerges from the catheter 30. The external anchoring member 250 can be, for example, one or more loops 252, 254, or 256, or a stent 258. The distal end of the push wire 32 moves further until the external anchoring member 250 emerges from the catheter 30. The external anchoring member 250 can be, for example, one or more loops 252, 254, or 256, or a stent 258. The distal end of the push wire 32 moves further until the external anchoring member 250 emerges from the catheter 30. The external anchoring member 250 can be, for example, one or more loops 252, The distal end 36 is detached from the external anchoring member, and the catheter 30 and the push wire 32 can be withdrawn from the blood vessel 22, but the inner cover 22 remains at the neck portion 26 of the aneurysm 20 , the internal anchoring member 240 is coupled to the second surface 246, and the external anchoring member 25 0 is located within the blood vessel 12. In other embodiments, the push wire 32 can be directly coupled to the inner cover 22 2, and the external anchoring member 250 can be deployed separately (e.g., by another catheter ).

[0043] Referring to FIGS. 11-14, an occlusion device 320 according to an exemplary embodiment is shown disposed at the neck portion 16 of the aneurysm 10 to block or stop the flow of blood between the blood vessel 12 and the internal space 14 of the aneurysm, thereby reducing the likelihood of rupture of the aneurysm 10. The occlusion device 320 is configured as a low-profile device to minimize interference with surrounding tissues such as the branches 18 of the blood vessel 12. The occlusion device 320 can be composed of a biodegradable or bioabsorbable material and can be configured to promote endothelialization. The occlusion device 320 includes an inner cover 322 (e.g., a plate, a thin film, etc.) similar to the above-described inner cover 32 disposed within the internal space 14 of the aneurysm 10. The occlusion device 3 20 further includes an outer cover 360 located within the blood vessel 12 near the aneurysm 10. The outer cover

[0044] 360 can be coupled to the inner cover 322 to provide a relatively rigid body and support the inner cover 32. The outer cover 360 reduces the possibility that the inner cover 322 moves from the neck portion 34 due to the fluid pressure of the blood within the blood vessel 32. The outer cover 360 is an internal anchoring member 140 or an external anchoring member that fixes the inner cover 322 to the neck portion 16 360 can be further included. The outer cover 360 can be coupled to the inner cover 322 to provide a relatively rigid body and support the inner cover 32. By the outer cover 360, the possibility that the inner cover 322 moves from the neck portion 34 due to the fluid pressure of the blood within the blood vessel 32 is reduced. The outer cover 360 is an internal anchoring member 140 or an external anchoring member that fixes the inner cover 322 to the neck portion 16 32. By the outer cover 360, the possibility that the inner cover 322 moves from the neck portion 34 due to the fluid pressure of the blood within the blood vessel 32 is reduced. The outer cover 360 is an internal anchoring member 140 or an external anchoring member that fixes the inner cover 322 to the neck portion 16 322 to the neck portion 16, or an external anchoring It can be used with or instead of another device such as member 250.

[0045] Referring to FIG. 11, the external cover 360 according to the exemplary embodiment is a relatively thin member (e.g., a plate, sheet, etc.) formed from a suitable biocompatible member such as a metal or alloy (e.g., platinum, stainless steel, nickel titanium alloy, etc.) or a polymer (e.g., PTFE, etc.). According to the exemplary embodiment, the thickness of the external cover 360 is less than 2 mm. According to a preferred embodiment, the thickness of the external cover 360 is less than 1 mm. The external cover 360 is a low-profile body that does not substantially impede the flow of blood passing through the blood vessel 12. The external cover 360 includes a peripheral portion 362 that contacts the wall 13 of the blood vessel 12 around the neck portion 16 of the aneurysm 10, and a central portion 364 that is located at the neck portion 16. The central portion 36 4 can be integrally formed with the internal cover 322 or can be coupled to the internal cover 322 (e.g., by suitable adhesion). All or part of the external cover 360 can be coated or covered with a radiopaque material such as platinum so that the external cover 360 can be visualized (e.g., during or after the placement of the external cover 360). In an embodiment, the external cover 360 is attached to the internal cover in a central region that is smaller than the neck portion 16 (e.g., 90 percent, 75 percent, or 50 percent of the area of the neck portion). In one embodiment, the central region is circular in shape. The external cover 360 is not intended to occlude the neck portion 16 of the aneurysm 10 but forms a structure that aids in stopping the internal cover 322. Thus, the external cover 360 is the neck portion 39

[0046] 38 322. It is not necessary for the outer cover 360 to completely cover the neck portion 160. Therefore, the outer cover 360 may only partially cover the neck portion 160. in a form that is unwrapped and / or formed from a porous material (e.g., mesh) 12, in one embodiment, the outer cover 360 is The sheet completely covers the neck portion 16 so that the peripheral portion 362 of the sheet extends all around the neck portion 16. It could be.

[0047] Referring to FIG. 13, in another embodiment, an outer cover 360 extends outward from the neck portion 16. Each lobe may include multiple segments or sections, such as radial lobes 366. The protrusion 366 has a central portion 364 that is located within the neck portion 16 and a wide portion 366 that extends beyond the neck portion 16. The graft 362 may include a peripheral portion 364 that contacts the wall 13 of the blood vessel 12 .

[0048] Referring to FIG. 14, in another embodiment, the outer cover 360 includes a volute body 368. The inner loop of the volute body 368 may form a central portion 364, The outer loop of the fiber 368 may form the peripheral portion 362 .

[0049] The outer cover 360 may be deployed from the catheter in the same manner as the inner cover 322. The outer cover 360 is then joined to the inner cover 322 and folded to be covered within the catheter. The outer cover 360 may be configured to be folded in the catheter. It may be configured to couple with the inner cover 322 and be located upstream of the peripheral portion 362. The inner cover 322 can be deployed as described with reference to Figures 3A-D. When the catheter is deployed and positioned within the neck portion 16, the push wire of the catheter It may further proceed forward to deploy the outer cover 360. By the blood fluid pressure in the blood vessel 12, the outer cover 360 is opposed to the wall 13 of the blood vessel 12. In other embodiments, the push wire 32 may be directly coupled to the inner cover 322, and the outer cover 360 may be deployed separately (e.g., by another catheter).

[0050] Referring to FIGS. 15-16, an occlusion device 420 according to an exemplary embodiment is shown disposed at the neck portion 16 of the aneurysm 10. The occlusion device 420 includes an inner cover 422 (e.g., a plate, a thin film, etc.) disposed within the inner space 14 of the aneurysm 10. The occlusion device 420 further includes an internal anchoring member 440 disposed within the aneurysm 10 and / or an external anchoring member 450. The internal anchoring member 440 is configured to stop the inner cover 422 within the aneurysm 10 at the neck portion 16. According to the exemplary embodiment, the internal anchoring member 440 includes one or more struts or arms formed from a suitable biocompatible metal or alloy (e.g., platinum, stainless steel, nickel-titanium alloy, etc.). The internal anchoring member 440 is coupled to the inner cover 122, extends beyond the periphery of the inner cover 422, and is configured to contact the inner surface 15 of the aneurysm 10. Thus, the internal anchoring member 140 can be used to assist in positioning the inner cover 42 2 of the aneurysm 10 having a relatively wide neck 16. The struts or arms of the internal anchoring member 140 do not fill the entire inner space 14 or substantially a part of the inner space 14. Since the size of the aneurysm 10 shrinks as the blood vessel heals, the pressure on the surrounding tissue due to the aneurysm is reduced, and the "mass effect" of the aneurysm 10 is decreased. The internal anchoring member 4 is coupled to the inner cover 422, extends beyond the periphery of the inner cover 422, and is configured to contact the inner surface 15 of the aneurysm 10. Thus, the internal anchoring member 140 can be used to assist in positioning the inner cover 42 2 of the aneurysm 10 having a relatively wide neck 16. The struts or arms of the internal anchoring member 140 do not fill the entire inner space 14 or substantially a part of the inner space 14. Since the size of the aneurysm 10 shrinks as the blood vessel heals, the pressure on the surrounding tissue due to the aneurysm is reduced, and the "mass effect" of the aneurysm 10 is decreased. The internal anchoring member 4 2 of the aneurysm 10 having a relatively wide neck 16. The struts or arms of the internal anchoring member 140 do not fill the entire inner space 14 or substantially a part of the inner space 14. Since the size of the aneurysm 10 shrinks as the blood vessel heals, the pressure on the surrounding tissue due to the aneurysm is reduced, and the "mass effect" of the aneurysm 10 is decreased. The internal anchoring member 4 does not fill the entire inner space 14 or substantially a part of the inner space 14. As the blood vessel heals, the aneurysm 10 shrinks, reducing the pressure on the surrounding tissue and decreasing the "mass effect" of the aneurysm 10. The internal anchoring member 4 The orientation, number, and length of the 40 arms can vary depending on the size and shape of the aneurysm 10. Similar to the microcatheter 30 described above, the arms of the internal anchoring member 440 can be configured to be folded together so as to be conveyed by the microcatheter.

[0051] Referring further to FIGS. 15-16, the external anchoring member 450 includes a first portion 452 (e.g., a distal portion) located at the neck 16 and coupled to the inner cover 420, and a second portion 454 (e.g., a proximal portion) located within the blood vessel 12. The external anchoring member 450 is formed from a suitable biocompatible metal or alloy (e.g., platinum, stainless steel, nickel-titanium alloy, etc.) or a suitable biocompatible polymer. All or part of the external anchoring member 450 can be coated or covered with a radiopaque material such as platinum, so that the external anchoring member 450 can be visualized (e.g., during or after placement of the external anchoring member 450). The external anchoring member 450 is guided to the blood vessel 12 near the aneurysm 10 in a folded state (e.g., straight) by a catheter. Once deployed within the blood vessel 12, the external anchoring member 450 expands such that at least a portion of the external anchoring member presses against the wall of the blood vessel 12. The external anchoring member 450 can be formed as a single continuous spiral, and the loops of the spiral can be formed to have various characteristics (e.g., diameter, thickness, flexibility, etc.). For example, the first portion 452 can be formed to be a coil with a relatively small diameter and flexibility, while the second portion 454 can be formed to be a large, relatively rigid coil, and the external anchoring member along the wall 13 of the blood vessel 12 ​ Provide a radially outwardly increasing force to cause 450 to be disposed.

[0052] Referring to FIG. 17, a portion of an external anchoring member 460 according to another exemplary embodiment may be formed of a double spiral. According to other exemplary embodiments, the external anchoring member may be of various other shapes (e.g., spider web shape, star shape, etc.) and provide the desired flexibility to support the inner cover at the neck portion of the aneurysm. Referring to FIGS. 18A - 18B, an inner cover 470 for an occlusion device according to another exemplary embodiment may be a star-shaped body. The inner cover 470 is formed (e.g., by folding, perforating, molding) and folded along predefined folds. Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small.

[0053] Referring to FIGS. 18A - 18B, an inner cover 470 for an occlusion device according to another exemplary embodiment may be a star-shaped body. The inner cover 470 is formed (e.g., by folding, perforating, molding) and folded along predefined folds. Referring to FIGS. 18A - 18B, an inner cover 470 for an occlusion device according to another exemplary embodiment may be a star-shaped body. The inner cover 470 is formed (e.g., by folding, perforating, molding) and folded along predefined folds. Referring to FIGS. 18A - 18B, an inner cover 470 for an occlusion device according to another exemplary embodiment may be a star-shaped body. The inner cover 470 is formed (e.g., by folding, perforating, molding) and folded along predefined folds. Referring to FIGS. 18A - 18B, an inner cover 470 for an occlusion device according to another exemplary embodiment may be a star-shaped body. The inner cover 470 is formed (e.g., by folding, perforating, molding) and folded along predefined folds.

[0054] Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small. Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small. Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small. Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small. Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small. Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small. Referring to FIG. 19, an occlusion device 480 having an external anchoring member 482 is illustrated. The external anchoring member 482 may be a body of various shapes (e.g., straight, spiral, multi-spiral, assembly, etc.). The external anchoring member 482 is formed in a relatively open structure with a minimum number of segments that can form a structure for placing and fixing the occlusion device 480, minimizing contact with the blood vessel wall. Due to the open nature of the external anchoring member 482, the risk of constricting the branches of the blood vessel, i.e., the risk of changing the blood flow through the blood vessel, is small.

[0055] Referring to FIG. 20, an inner anchoring ring member 494 for an occlusion device 490 according to another exemplary embodiment is illustrated. The inner anchoring member 494 is coupled to the cover 492. Referring to FIG. 20, an inner anchoring ring member 494 for an occlusion device 490 according to another exemplary embodiment is illustrated. The inner anchoring member 494 is coupled to the cover 492. It includes a central wire 496 and one or more outer wires 498 coupled to the central wire 496. The outer wire 498 extends outward from the central wire 496 and contacts the inner surface 15 of the aneurysm 10. The inner anchoring member 494 is inserted into the aneurysm 10 by the catheter 30 in a folded (e.g., straight) state. Once inserted into the aneurysm 10, the catheter 30 is pulled, and the outer wire 498 can extend outward, and at least a portion of the outer wire 498 contacts the inner surface 15, and the cover 492 is placed on the neck 16 to stop it. Once inserted into the aneurysm 10, the catheter 30 is pulled, and the outer wire 498 can extend outward, and at least a portion of the outer wire 498 contacts the inner surface 15, and the cover 492 is placed on the neck 16 to stop it. The outer wire 498 extends outward from the central wire 496 and contacts the inner surface 15 of the aneurysm 10. Once inserted into the aneurysm 10, the catheter 30 is pulled, and the outer wire 498 can extend outward, and at least a portion of the outer wire 498 contacts the inner surface 15, and the cover 492 is placed on the neck 16 to stop it. Once inserted into the aneurysm 10, the catheter 30 is pulled, and the outer wire 498 can extend outward, and at least a portion of the outer wire 498 contacts the inner surface 15, and the cover 492 is placed on the neck 16 to stop it.

[0056] The configurations and arrangements of the elements of the aneurysm occlusion device illustrated in various exemplary embodiments are used for illustrative purposes only. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. Only some embodiments are described in detail in this specification, but those skilled in the art who refer to this disclosure will immediately understand that many variations (e.g., size, dimensions, configuration, shape variations, and ratios of various elements, values of parameters, attachment methods, materials used, colors, orientations, etc.) are possible without departing from the novel teachings and advantageous points of the invention described herein. For example, an element shown as integrally formed may be composed of a plurality of parts or elements, the position of the element may be reversed or changed, and the characteristics or number or position of discrete elements can be changed. It should be noted that the elements and / or assemblies of the system can be composed of any of a variety of materials having sufficient strength, durability, or biocompatibility. Other alternative, modified, variant, and omitted forms are designs, other preferred exemplary embodiments that do not depart from the scope of the present invention. It is within the operating conditions and the range of arrangement of the calling medical procedure.

Claims

1. An apparatus for treating an aneurysm within a blood vessel, comprising: a push wire; an occlusion element disposed on the push wire, the occlusion element including a cover and a single internal anchoring member; wherein the push wire is coupled to the cover and extends proximally from a proximal side of the cover, the internal anchoring member is coupled to the cover at the proximal side of the cover and extends distally from the cover, the occlusion element is configured to fit within a lumen of a catheter and slide out of an opening at a distal end of the catheter in response to movement of the push wire relative to the catheter, the cover is configured to expand into an expanded configuration when advanced from a distal end of the catheter, in the expanded configuration, the cover is configured to cover a neck portion of the aneurysm and contact an inner surface of the aneurysm, the internal anchoring member is a single loop, the internal anchoring member has a folded configuration and an expanded configuration, and the internal anchoring member expands into the expanded configuration when the catheter is retracted and / or the push wire is advanced such that the occlusion element is deployed within the aneurysm, and in the expanded configuration, the single loop is configured to contact the inner surface of the aneurysm to fix the cover to the neck portion.

2. The apparatus of claim 1, wherein the cover has a closed umbrella shape while within the lumen of the catheter and an open umbrella shape when expanded into the expanded configuration.

3. The apparatus of claim 1, wherein the cover includes a concave shape in the expanded configuration.

4. The apparatus of claim 1, wherein the cover includes a plurality of fibers.

5. The apparatus of claim 1, further comprising an external anchoring member coupled to the cover, wherein at least a portion of the external anchoring member is configured to be disposed on a side of the blood vessel of the neck portion within the blood vessel near the aneurysm such that the at least a portion of the external anchoring member contacts an inner surface of the blood vessel.

6. The apparatus of claim 5, wherein the external anchoring member includes at least three radially rounded protrusions that extend outwardly from the cover to engage the inner surface of the blood vessel.

7. The push wire is coupled to the first surface of the cover, and the internal anchoring member is coupled to the second surface of the cover opposite the first surface, the apparatus according to claim 1.

8. The cover is disk-shaped, the apparatus according to claim 1.

9. The cover has an outer diameter of 5 mm to 12 mm, the apparatus according to claim 8.

10. The cover includes a mesh, the apparatus according to claim 1.

11. The cover includes a metal, the apparatus according to claim 1.

12. The cover includes a three-dimensionally printed material, the apparatus according to claim 1.

13. The cover includes a conical shape, the apparatus according to claim 1.

14. The cover has a thickness of less than 100 micrometers, the apparatus according to claim 1.

15. The cover includes platinum, the apparatus according to claim 1.

16. The cover includes a nickel-titanium alloy, the apparatus according to claim 1.

17. The apparatus according to claim 1, further comprising a stent configured to support the cover after the cover is expanded and detached from the push wire.

18. The stent is configured to press against the inner surface of the blood vessel, the apparatus according to claim 17.

19. The stent is self-expandable, the apparatus according to claim 17.

20. The cover is biased toward the expanded configuration, the apparatus according to claim 1.

21. The occlusion element is configured to be detached from the push wire after the cover and the internal anchoring member are expanded, the apparatus according to any one of claims 1 to 20.

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