Composition for stabilizing poorly soluble components and cosmetic composition containing the same

Abstract

To provide a cosmetic composition that sufficiently exerts functional effects of a poorly soluble ingredient and causes no precipitation.SOLUTION: The present invention relates to a composition for stabilizing poorly soluble ingredients, comprising hydrogenated lecithin and an anionic surfactant as active ingredients. In addition, the present invention relates to a method for stabilizing poorly soluble ingredients in cosmetic formulations by using the composition for stabilizing poorly soluble ingredients, a cosmetic composition comprising the composition for stabilizing poorly soluble ingredients and a poorly soluble component, and a preparation method of the cosmetic composition. The composition for stabilizing poorly soluble ingredients of the present invention stabilizes the poorly soluble ingredients in cosmetic formulations, thereby preventing separation and precipitation. Accordingly, by overcoming the limitations of poorly soluble ingredients that tend to precipitate over time and thus have been difficult to apply to cosmetic compositions, the present invention can provide a cosmetic composition containing poorly soluble ingredients having various types of formulations.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a composition for stabilizing a poorly soluble component, which comprises hydrogenated lecithin and an anionic surfactant as active ingredients.

[0002] The present invention relates to a method for stabilizing a poorly soluble component in a cosmetic formulation using the composition for stabilizing a poorly soluble component, a cosmetic composition containing the composition for stabilizing a poorly soluble component and the poorly soluble component, and a method for producing the cosmetic composition. [Background technology]

[0003] In the development of cosmetics, many ingredients that provide skin-improving effects such as whitening and wrinkle reduction contain poorly soluble substances that are neither water-soluble nor oil-soluble. In order to incorporate such poorly soluble substances into cosmetics and provide skin-improving effects, various methods have been attempted to stabilize them.

[0004] For example, a cream formulation containing no water, an excess amount of polyol, and an emulsifier with occlusive power was developed in an attempt to stabilize ingredients that easily precipitate in water and impart spreadability and occlusive power to cosmetic products (Patent Document 1). However, other problems remain, such as instability over time and a heavy feeling when used due to the use of an excessive amount of polyol.

[0005] In addition to these formulation technologies, research is also underway to develop pharmaceutically usable compositions by preparing and stabilizing poorly soluble drugs in the form of polymeric micelles or nanoparticles using amphiphilic block copolymers (Patent Document 2). However, when these are prepared into cosmetic products, aggregation between the block copolymers occurs, and the problem of precipitation over time still remains, so there are still limitations to stabilizing poorly soluble substances for use in products. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Korean Patent Publication No. 10-2016-0031850 [Patent Document 2] Korean Patent Publication No. 10-2010-0084399 Summary of the Invention [Problem to be solved by the invention]

[0007] The present inventors conducted research to develop a cosmetic composition that would fully exhibit the functional effects of a poorly soluble ingredient without causing precipitation. As a result, they found that a combination of hydrogenated lecithin and an anionic surfactant could be used to sufficiently stabilize a poorly soluble substance in a cosmetic formulation, leading to the completion of the present invention. [Means for solving the problem]

[0008] An object of the present invention is to provide a composition for stabilizing poorly soluble components, which comprises hydrogenated lecithin and an anionic surfactant as active ingredients.

[0009] Another object of the present invention is to provide a cosmetic composition containing the composition for stabilizing a poorly soluble component and the poorly soluble component.

[0010] A further object of the present invention is to provide a method for stabilizing a poorly soluble ingredient in a cosmetic formulation, which comprises the step of mixing hydrogenated lecithin with an anionic surfactant.

[0011] Another object of the present invention is to provide a method for producing a cosmetic composition in which a poorly soluble component is dissolved. [Effects of the Invention]

[0012] The composition for stabilizing a poorly soluble active ingredient of the present invention stabilizes the poorly soluble ingredient in the formulation of a cosmetic product, thereby preventing separation and precipitation. Therefore, by overcoming the limitations of poorly soluble ingredients, which have been difficult to apply to cosmetic compositions due to the problem of precipitation over time, it is possible to provide cosmetic compositions containing poorly soluble ingredients in various types of formulations. [Brief explanation of the drawings]

[0013] [Figure 1] 1 is a photograph showing the turbidity of dosage forms at various weight ratios of hydrogenated lecithin and cetyl phosphate. [Figure 2] 1 shows photographs of Example 10 and Comparative Example 1 observed with a microscope to examine the stability over time. DETAILED DESCRIPTION OF THE INVENTION

[0014] These will be described in detail below. Note that each description and embodiment disclosed in the present invention also applies to other descriptions and embodiments. In other words, all combinations of various elements disclosed in the present invention are included in the present invention. Furthermore, the present invention is not limited to the following specific description.

[0015] One aspect of the present invention provides a composition for stabilizing a poorly soluble component, which comprises hydrogenated lecithin and an anionic surfactant as active ingredients.

[0016] Generally, it is difficult to stably contain poorly soluble ingredients that have low solubility in both the oil phase and the aqueous phase using only the stabilizers used in cosmetics. The poorly soluble ingredients exist in an unstable state in the cosmetic formulation, and this instability increases over time, leading to the problem of recrystallization and precipitation.

[0017] To solve the above problems, the present invention has developed a composition for stably incorporating poorly soluble ingredients into cosmetic formulations. By mixing hydrogenated lecithin with an anionic surfactant, a low-viscosity, transparent formulation was produced that forms a stable structure, i.e., micelles, without undergoing a high-pressure emulsification process. Furthermore, by stabilizing the poorly soluble ingredients in this stable structure, separation and precipitation of the poorly soluble ingredients are prevented.

[0018] "Hydrogenated lecithin" in the present invention refers to a hydrogenated product of lecithin, and plays a role in improving the stability of the structure. Lecithin is a representative naturally occurring surfactant and refers to a group of yellowish-brown fatty substances derived from animal and plant tissues, which are composed of phosphoric acid, choline, fatty acids, glycerin, glycolipids, triglycerides, and phospholipids. The lecithin in the present invention includes all naturally occurring lecithins extracted from animals and plants such as egg yolk, soybean, and corn, and microorganisms such as E. coli, as well as synthetic lecithins. Specific examples of lecithin include, but are not limited to, natural phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, lysophosphatidylcholine, sphingomyelin, egg yolk lecithin, and soybean lecithin, as well as synthetic lecithins such as dilauroylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, dioleoylphosphatidylcholine, palmitoylphosphatidylcholine, and oleoylphosphatidylcholine. Generally, naturally occurring lecithins have a phosphatidylcholine content of 23 to 95% by weight and a phosphatidylethanolamine content of 20% by weight or less, but are not limited to these.

[0019] The hydrogenated lecithin used in the present invention has a hydrogenated phosphatidylcholine content of 10 to 99% by weight, specifically 50 to 90% by weight, but is not limited thereto.

[0020] When hydrogenated lecithin is used alone as a stabilizer in a cosmetic formulation, a liposome-shaped structure is formed. However, this structure is open and highly flexible, making it difficult to maintain its shape, as it is prone to deformation and collapse. This makes it difficult to ensure the stability of poorly soluble substances, and stability changes significantly over time. In the present invention, this problem is solved by using an anionic surfactant together with hydrogenated lecithin.

[0021] The hydrogenated lecithin is contained in an amount of 0.1 to 20% by weight, specifically 0.3 to 10% by weight, 0.5 to 5% by weight, or 1 to 5% by weight, based on the total weight of the composition for stabilizing a poorly soluble component, but is not limited to these.

[0022] If the content of hydrogenated lecithin is less than 0.1% by weight, the poorly soluble components cannot be sufficiently dissolved, which may result in precipitation or deposition of the poorly soluble components. If the content exceeds 20% by weight, the particle size of the structure increases, which may result in an unstable dosage form.

[0023] In the present invention, the term "anionic surfactant" refers to a surfactant containing only anionic functional groups as ionic or ionizable groups. When mixed with hydrogenated lecithin, the anionic surfactant forms a low-viscosity, transparent formulation, adjusting the packing parameters of the hydrogenated lecithin to form a stable structure with the lecithin. The structure thus prepared stabilizes the poorly soluble components, thereby preventing their separation or precipitation.

[0024] In the present invention, any conventional anionic surfactant known in the art can be used, and the anionic functional group contained in the anionic surfactant is specifically PO4 3- , -CO2 - , -SO3 - , -OSO3 - , -HPO3 - , -PO3 2- , -HPO2- , -PO2 2- , -PO - or a combination thereof, more specifically phosphate (PO4 3- ), metal salts of carboxylic acids, such as sodium, potassium, ammonium, magnesium salts, especially sodium salts of carboxylic acids, or combinations thereof, but are not limited thereto. Any other type of lecithin that can be mixed with hydrogenated lecithin to form a stable structure can also be used.

[0025] Specifically, the anionic surfactant may be an amino acid derived surfactant, alkyl phosphate, alkyl sulfate, alkyl ether sulfate, alkyl monoglyceryl ether sulfate, alkyl sulfonate, alkyl aryl sulfonate, alkyl sulfosuccinate, alkyl ether sulfosuccinate, alkyl amido sulfosuccinamate, alkyl amido sulfosuccinate, alkyl carboxylate, alkyl amido ether carboxylate, alkyl succinate, fatty acyl sarcosinate, fatty acyl amino acid ester, fatty acyl taurate ester, fatty alkyl sulfoacetate, or a combination thereof, specifically, but not limited to, alkyl phosphate.

[0026] The amino acid-derived surfactant is derived from a carboxylic acid ester of an amino acid, and specifically may include sodium dilauramidoglutamide lysine, which has a glutamic acid-lysine-glutamic acid structure derived from lysine.

[0027] The alkyl phosphate may be cetyl phosphate, PPG-10 cetyl phosphate, PPG-5-ceteth-10 phosphate, oleth-3 phosphate, oleth-10 phosphate, ceteth-10 phosphate, dicetyl phosphate, stearyl phosphate, or mixtures thereof, more specifically, but not limited to, cetyl phosphate.

[0028] Specifically, for purposes of the present invention, the anionic surfactant may be cetyl phosphate, sodium dilauramidoglutamide lysine, or a mixture thereof, and by mixing the above substances with hydrogenated lecithin, a composition can be produced that stabilizes poorly soluble ingredients in a cosmetic composition.

[0029] In the present invention, the anionic surfactant is contained in an amount of 0.001 to 4 wt % relative to the total weight of the composition for stabilizing poorly soluble components, specifically 0.01 to 2 wt %, 0.2 to 1.0 wt %, or 0.1 to 0.5 wt %, but is not limited to these.

[0030] If the content of the anionic surfactant is less than 0.001% by weight, the packing parameters of the hydrogenated lecithin cannot be adjusted, and a transparent dosage form cannot be produced. If the content exceeds 4% by weight, the anionic surfactant will precipitate.

[0031] The stability of the composition can be varied depending on the mixing ratio of hydrogenated lecithin to anionic surfactant contained in the composition for stabilizing a poorly soluble component of the present invention. Furthermore, the mixing ratio of hydrogenated lecithin to anionic surfactant that maximizes the stability of the composition can be varied depending on the type of anionic surfactant.

[0032] Specifically, when the anionic surfactant is cetyl phosphate, the mixing ratio of hydrogenated lecithin to anionic surfactant may be 1:0.005-40 by weight, more specifically 1:0.02-1, 1:0.05-1, 1:0.2-1, 1:0.2-0.5, 1:0.2-0.3, or 1:0.2-0.25, but is not limited to these.

[0033] Furthermore, when the anionic surfactant is dilauramidoglutamide lysine sodium, the mixing ratio of hydrogenated lecithin to anionic surfactant may be 1:0.005-40 by weight, more specifically 1:0.1-2, 1:0.3-2, greater than 1:0.6 and not greater than 1:2, greater than 1:0.6 and not greater than 1:1, greater than 1:0.6 and not greater than 1:0.8, or 1:0.8-1:1, but is not limited to these.

[0034] The composition for stabilizing a poorly soluble component of the present invention may further comprise an oil. When the composition for stabilizing a poorly soluble component of the present invention further comprises an oil, the stabilization effect of the poorly soluble component is further enhanced. The oil may be any oil commonly used in the art.

[0035] Specifically, the oil may be, but is not limited to, a hydrocarbon oil, an ester oil, a silicone oil, or a mixture thereof. Examples of the hydrocarbon oil include hydrogenated polyisobutene, hydrogenated polydecene, paraffin, and a combination thereof. Examples of the ester oil include dipentaerythrityl hexa-C 5-9 Acid ester, diisostearyl malate, C 12-15Examples of the usable surfactant include alkyl octanoate, myristyl lactate, cetyl ethylhexanoate, cetyl octanoate, isopropyl myristate, octyldodecyl myristate, hexyl laurate, pentaerythrityl tetraethylhexanoate, diglyceryl triisostearate, and combinations thereof. Examples of the usable surfactant include dimethicone, cyclomethicone, polydimethylsiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetradecamethylhexasiloxane, octamethyltrisiloxane, and combinations thereof. For the purposes of the present invention, hydrogenated polyisobutene can also be used, but is not limited to these.

[0036] In one example of the present invention, a composition for stabilizing poorly soluble ingredients containing hydrogenated lecithin, cetyl phosphate, and hydrogenated polyisobutene was prepared, and when this composition was incorporated into a cosmetic formulation together with the poorly soluble ingredient, it was confirmed that the properties of the cosmetic formulation were maintained even four weeks after production, no precipitation occurred, and the poorly soluble ingredient was stably dissolved for a long period of time (Table 7).

[0037] Another aspect of the present invention provides a cosmetic composition comprising the composition for stabilizing a poorly soluble component and a poorly soluble component.

[0038] The "composition for stabilizing a poorly soluble component" is as described above.

[0039] In the present invention, the term "poorly soluble component" refers to a substance that is not sufficiently soluble in water or oil and exists unstable, and is used in cosmetic compositions to impart beneficial effects to the skin, such as wrinkle improvement, skin whitening, and skin moisturizing.

[0040] Specifically, the poorly soluble components contained in the composition of the present invention are cedrol, formononetin, magnolol, honokiol, phloretin, ceramide, Centella asiatica quantitative extract, fisetin, daidzein, genistein, glycitein, adenosine, polydatin, retinol, γ-aminobutyric acid, arbutin, macelignan, acetyl phytosphingosine, hydroquinone, hydroxyanisole, ascorbic acid, and kojic acid. The present invention is directed to at least one selected from the group consisting of retinoids, specifically cedrol, but is not limited to these. Any type of ingredient commonly used in the art to provide beneficial effects to the skin can be used in the present invention.

[0041] In one example of the present invention, it was confirmed that cedrol precipitation can be prevented by incorporating cedrol into a cosmetic formulation together with a mixture of hydrogenated lecithin and cetyl phosphate. Thus, the cosmetic composition of the present invention stably contains poorly soluble components, which is effective in preventing their separation or precipitation, specifically having the advantage that separation or precipitation does not occur at temperatures between -20 and 60°C. In other words, the cosmetic composition of the present invention can maintain a stable form for a long period of time not only at room temperature but also at low and high temperatures.

[0042] The composition for stabilizing a poorly soluble component of the present invention can stabilize the poorly soluble component across a variety of formulations, from high-viscosity formulations to low-viscosity formulations. The cosmetic composition containing the poorly soluble component of the present invention can be formulated into any formulation commonly produced in the art, and can be used in a variety of applications, such as high-viscosity creams, low-viscosity skin lotions, lotions, essences, mists, and spray formulations.

[0043] For example, the composition may be prepared into a dosage form selected from the group consisting of skin lotion, lotion, essence, cream or eye cream, solution, topical ointment, foam, nourishing lotion, softening lotion, pack, softening lotion, emulsion, makeup base, soap, liquid cleanser, bath additive, sunscreen cream, sun oil, suspension, emulsion, paste, gel, powder, surfactant-containing cleanser, oil, powder foundation, emulsion foundation, wax foundation, patch, and spray, but is not limited to these.

[0044] The cosmetic composition of the present invention may further contain one or more cosmetically acceptable carriers that are commonly incorporated into skin cosmetics, and may contain, as appropriate, common ingredients such as oils, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, preservatives, fragrances, etc., but is not limited to these. The cosmetically acceptable carriers contained in the cosmetic composition of the present invention vary depending on the formulation.

[0045] Yet another aspect of the present invention provides a method for stabilizing a poorly soluble ingredient in a cosmetic formulation, comprising the step of mixing hydrogenated lecithin with an anionic surfactant.

[0046] The "hydrogenated lecithin," "anionic surfactant," and "hardly soluble component" are as described above.

[0047] Specifically, by mixing a composition in which hydrogenated lecithin and an anionic surfactant are mixed together with a poorly soluble component, the poorly soluble component can be stabilized in the cosmetic composition.

[0048] The hydrogenated lecithin and the anionic surfactant may be added and mixed in order, in reverse order, or simultaneously. The poorly soluble component may be added after all of the hydrogenated lecithin and the anionic surfactant have been mixed, or the poorly soluble component may be mixed with the hydrogenated lecithin or the anionic surfactant before mixing, and then the remaining components may be added and mixed. The timing and order of adding and mixing these components are not critical, as long as a cosmetic composition containing all of the hydrogenated lecithin, the anionic surfactant, and the poorly soluble component can be ultimately produced, and the poorly soluble component can be stabilized.

[0049] The anionic surfactant may be cetyl phosphate, sodium dilauramidoglutamide lysine, or a mixture thereof.

[0050] Yet another aspect of the present invention provides a method for producing a cosmetic composition having a poorly soluble component dissolved therein, the method comprising: (S1) a step of adding a poorly soluble component, hydrogenated lecithin, and an anionic surfactant to a solvent; and (S2) a step of adding the product of step S1 to an aqueous phase.

[0051] The anionic surfactant may be cetyl phosphate, sodium dilauramidoglutamide lysine, or a mixture thereof.

[0052] The "hydrogenated lecithin," "anionic surfactant," and "hardly soluble component" are as described above.

[0053] The cosmetic composition produced by the production method of the present invention contains a poorly soluble component in a stable manner, and therefore can be maintained stable over a long period of time under various dosage forms and temperature conditions without separation or precipitation of the poorly soluble component. [Example]

[0054] The present invention will be described in detail below with reference to examples to facilitate understanding of the present invention. However, the examples of the present invention may be modified into various other forms, and the present invention is not limited to these examples. The examples of the present invention are provided to more completely explain the present invention to those skilled in the art.

[0055] Experimental Example 1: Confirmation of dosage form properties and turbidity of the composition for stabilizing poorly soluble ingredients 1-1. Production of a composition for stabilizing poorly soluble components As shown in Table 1, cosmetic compositions containing various types of ingredients were prepared.

[0056] First, the oil phase and the water phase were each heated to 65°C and dissolved. The oil phase was gradually added to the water phase while stirring at 2000 rpm with a homomixer. After the oil phase was completely added, the mixture was stirred at 2000-2500 rpm with a homomixer for 3 minutes, and then cooled to 28°C to produce a composition for stabilizing poorly soluble ingredients. The composition was prepared in the form of a skin lotion.

[0057] [Table 1]

[0058] [Table 2]

[0059] 1-2. Measurement of dosage form properties and turbidity immediately after manufacturing To confirm whether the dosage form of the composition for stabilizing a poorly soluble component prepared in Preparation Example 1 was transparent, the properties of the composition were observed immediately after preparation in Preparation Example 1. To compare the dosage form properties, the degree of turbidity was confirmed with the naked eye and measured using a turbidity meter. The turbidity was measured using a HACH TL2350 model, which measures turbidity by a light scattering method, and the average value of a total of five measurements is shown. Each example was measured at 25°C. The results are shown in Table 3.

[0060] [Table 3]

[0061] As can be seen from Table 3 and Figure 1, the composition became more transparent as the content of cetyl phosphate or sodium dilauramidoglutamide lysine increased relative to the content of hydrogenated lecithin. This was confirmed by both visual observation and turbidity measurement.

[0062] 1-3. Comparison of dosage form properties and turbidity over time In order to investigate the conditions for hydrogenated lecithin and anionic surfactant suitable for stabilizing poorly soluble components, the formulation stability over time of the cosmetic compositions of Examples 1 to 8 was evaluated. A comparative experiment of formulation properties was conducted in the same manner as in Experimental Example 1. The results are shown in Tables 4 and 5.

[0063] [Table 4]

[0064] [Table 5]

[0065] As shown in Table 4, even when the cetyl phosphate content was increased compared to the hydrogenated lecithin content, the properties did not change at room temperature and the transparency was maintained, whereas in Examples 1 to 3, in which the cetyl phosphate content was relatively low, the properties changed over time and turbidity was observed.

[0066] On the other hand, when comparing long-term stability, in Examples 1 to 3, in which hydrogenated lecithin was 1% by weight and cetyl phosphate was 0.15% by weight or less, the properties changed from the next day to within one week after production, turbidity occurred, and suspension occurred even at stability at -20°C.

[0067] On the other hand, in Examples 4 and 5, in which the cetyl phosphate was 0.2% by weight or more, the properties were maintained even four weeks after production. This suggests that the weight ratio of hydrogenated lecithin to cetyl phosphate is important, and that the stability of the composition for stabilizing a poorly soluble component is maintained as long as the weight of cetyl phosphate per part by weight of hydrogenated lecithin is 0.2 parts by weight or more.

[0068] Furthermore, as shown in Table 5, even when the content of sodium dilauramidoglutamate lysine was increased compared to the content of hydrogenated lecithin, the properties did not change at room temperature and the transparency was maintained, whereas in Examples 6 and 7, in which the content of sodium dilauramidoglutamic acid lysine was relatively low, the properties changed over time and turbidity was observed.

[0069] When comparing long-term stability, in Examples 6 and 7, in which hydrogenated lecithin was 1% by weight and dilauramidoglutamide lysine sodium was 0.6% by weight or less, the properties changed from the next day, turbidity occurred, and suspension occurred even at stability at -20°C.

[0070] On the other hand, in Example 8, in which the amount of sodium dilauramidoglutamide lysine was greater than 0.6% by weight, the properties were maintained even four weeks after production. This suggests that the weight ratio of hydrogenated lecithin to sodium dilauramidoglutamide lysine is important, and that if the amount of sodium dilauramidoglutamide lysine is greater than 0.6 parts by weight per part by weight of hydrogenated lecithin, the stability of the composition for stabilizing a poorly soluble component will be even better.

[0071] Experimental Example 2: Comparison of formulation properties and stability of cosmetic compositions containing poorly soluble ingredients 2-1. Production of cosmetic compositions containing poorly soluble ingredients In Experimental Example 1, it was confirmed that the composition for stabilizing a poorly soluble component of Example 4, in which the mixing ratio of hydrogenated lecithin to anionic surfactant was 1:0.2, had the best stability. Therefore, an actual cosmetic composition was prepared by adding a poorly soluble component to the composition for stabilizing a poorly soluble component of Example 4.

[0072] Specifically, a cosmetic composition was prepared with the ingredients and amounts shown in Table 6. First, the aqueous phase and oil phase were each heated to 65°C and dissolved. The oil phase was gradually added to the aqueous phase while stirring at 2000 rpm with a homomixer. After the oil phase was completely added, the mixture was stirred at 2000-2500 rpm with a homomixer for 3 minutes, and then cooled to 28°C. The cosmetic composition containing the poorly soluble active ingredient was prepared in the form of a skin lotion.

[0073] [Table 6]

[0074] 2-2. Comparison of dosage form properties and stability To investigate the conditions suitable for the poorly soluble active ingredient (cedrol), the formulation stability of the cosmetic compositions of Examples 9 to 11 and Comparative Examples 1 and 2 was evaluated. Stability was evaluated by sealing the compositions in a transparent plastic container with a lid and storing them at room temperature, and evaluating them visually and microscopically. The results are shown in Table 7.

[0075] [Table 7]

[0076] As shown in Table 7, in Examples 9 to 11, which used hydrogenated lecithin and cetyl phosphate, no precipitation occurred at room temperature. In contrast, in Comparative Example 2, in which no cetyl phosphate was added and the cedrol content was increased, precipitation occurred from the first day after production.

[0077] Comparing long-term stability, in Comparative Examples 1 and 2, which are general solubilized dosage forms without cetyl phosphate, precipitation occurred within one week after production. On the other hand, in Example 9, which does not contain hydrogenated polyisobutene, precipitation occurred four weeks after production. In Examples 10 and 11, which use hydrogenated polyisobutene, no precipitation occurred even four weeks after production, and properties were maintained. The dosage form stability over time of Example 10 and Comparative Example 1 was observed using a polarizing microscope. The results are shown in Figure 2.

[0078] These results confirmed that the stability of poorly soluble ingredients such as cedrol is enhanced in cosmetic compositions containing hydrogenated lecithin and cetyl phosphate, and that the use of an oil such as hydrogenated polyisobutene together is even more advantageous for long-term stability.

[0079] Experimental Example 3: Comparison of formulation properties and stability at various viscosities of cosmetic compositions 3-1. Production of low-viscosity and high-viscosity transparent cosmetic compositions Low-viscosity and high-viscosity transparent cosmetic compositions were prepared using the ingredients and amounts shown in Table 8. The preparation method was the same as in Experimental Example 2-1.

[0080] [Table 8]

[0081] 3-2. Comparison of dosage form properties and stability To confirm the stability of various dosage forms (low-viscosity and high-viscosity transparent dosage forms) containing poorly soluble active ingredients, the stability of Examples 12 to 14 was evaluated. Stability was evaluated by sealing the formulations in transparent plastic containers with lids and storing them at room temperature and at -20°C, followed by visual observation. The results are shown in Table 9.

[0082] [Table 9]

[0083] As shown in Table 9, it was confirmed that cedrol did not precipitate and remained stable for up to four weeks after production in all of the various formulations of Examples 12 to 14. In other words, it was found that the cosmetic composition produced by the present invention can stabilize poorly soluble ingredients in various formulations.

[0084] From the above description, those skilled in the art to which the present invention pertains will understand that the present invention can be embodied in other specific forms without changing the technical spirit or essential features thereof. It should be understood that the above examples are merely illustrative and not limiting. The present invention should be construed as including all modifications and variations derived from the meaning and scope of the claims, rather than the specification, and their equivalents.

Claims

1. A composition for stabilizing a poorly soluble component, comprising hydrogenated lecithin and an anionic surfactant as active ingredients, The poorly soluble component is cedrol, further comprising a hydrocarbon-based oil selected from hydrogenated polyisobutene, hydrogenated polydecene, paraffin, or a combination thereof; the anionic surfactant is cetyl phosphate; the mixing ratio of the hydrogenated lecithin to the cetyl phosphate is 1:0.2 to 1:0.25 by weight; The hydrogenated lecithin is contained in an amount of 0.1 to 20% by weight based on the total weight of the composition for stabilizing a poorly soluble component, The composition for stabilizing a poorly soluble component contains the anionic surfactant in an amount of 0.02 to 4% by weight based on the total weight of the composition for stabilizing a poorly soluble component.

2. The composition for stabilizing a poorly soluble component according to claim 1 , wherein the composition is transparent.

3. A cosmetic composition comprising the composition for stabilizing a poorly soluble component according to claim 1 or 2 and a poorly soluble component.

4. A method for stabilizing a poorly soluble ingredient in a cosmetic formulation, comprising the steps of mixing hydrogenated lecithin, an anionic surfactant, and a hydrocarbon oil, The poorly soluble component is cedrol, the hydrocarbon oil is selected from hydrogenated polyisobutene, hydrogenated polydecene, paraffin, or a combination thereof; the anionic surfactant is cetyl phosphate; the mixing ratio of the hydrogenated lecithin to the cetyl phosphate is 1:0.2 to 1:0.25 by weight; The hydrogenated lecithin is contained in an amount of 0.1 to 20% by weight based on the total weight of the cosmetic excluding the hardly soluble component, The method for stabilizing a poorly soluble component in a cosmetic formulation, wherein the anionic surfactant is contained in an amount of 0.02 to 4% by weight based on the total weight of the cosmetic excluding the poorly soluble component.

5. (S1) adding a poorly soluble component, hydrogenated lecithin, an anionic surfactant, and a hydrocarbon oil to a solvent; (S2) adding the product of step S1 to the aqueous phase; A method for producing a cosmetic composition in which a poorly soluble component is dissolved, comprising: The poorly soluble component is cedrol, the hydrocarbon oil is selected from hydrogenated polyisobutene, hydrogenated polydecene, paraffin, or a combination thereof; the anionic surfactant is cetyl phosphate; The mixing ratio of the hydrogenated lecithin to the cetyl phosphate is 1:0.2 to 1:0.25 by weight, the hydrogenated lecithin is contained in an amount of 0.1 to 20% by weight based on the total weight of the cosmetic composition excluding the hardly soluble component; A method for producing a cosmetic composition in which a poorly soluble component is dissolved, wherein the anionic surfactant is contained in an amount of 0.02 to 4% by weight based on the total weight of the cosmetic composition excluding the poorly soluble component.

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