Composition with effects of controlling oil and removing dandruff and application

Abstract

The invention relates to a composition with oil control and dandruff removal effects and application, and belongs to the technical field of cosmetics. The invention provides a composition with effects of controlling oil and removing dandruff. The composition is prepared from a soapberry fruit extract, a camellia seed extract, an artemisia annua extract, a fructus forsythiae extract, a fructus chebulae extract and an eclipta prostrata extract. Researches show that the composition composed of the components limited in the specific ratio can synergistically improve the 5alpha reductase inhibitory activity and the malassezia inhibitory activity, and the composition has remarkable oil control, bacteriostasis and dandruff removal effects. Furthermore, after the shampoo prepared from the composition provided by the invention is used in a short time, the scalp grease secretion and dandruff conditions of a subject are obviously improved. Therefore, the composition provided by the invention can efficiently regulate and control scalp micro-ecology and sebum secretion, remarkably reduce dandruff generation and realize the effects of controlling oil and removing dandruff.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a composition and its application that has oil-controlling and dandruff-removing effects. Background Technology

[0002] Problems such as abnormal scalp sebum secretion, increased dandruff, and accompanying itching are becoming increasingly common. Dandruff is related to factors such as abnormal sebum secretion, excessive proliferation of Malassezia, and imbalance of the scalp's microecology. Excessive proliferation of Malassezia can decompose sebum to produce irritating substances, triggering scalp inflammation and abnormal shedding, thereby aggravating scalp problems.

[0003] To address this issue, existing technologies often employ synthetic antibacterial agents such as clomiphene citrate (Ganbaosu), zinc pyrithione (ZPT), piroctone olamine (OCT), and ketoconazole to inhibit the proliferation of Malassezia; or use oil-controlling ingredients such as salicylic acid, capryloyl glycine, and zinc PCA to inhibit sebaceous gland activity and reduce oil buildup. However, long-term or high-dose use of these chemically synthesized ingredients can easily lead to scalp tolerance, resulting in decreased antibacterial activity and reduced dandruff-reducing effects; some ingredients, such as ZPT, may have potential irritant properties, potentially damaging the scalp barrier function. Furthermore, over-cleansing surfactant systems, while removing oil, can disrupt the scalp's water-oil balance, inducing compensatory sebum secretion and making it difficult to maintain the oil-controlling effect. Therefore, oil-controlling and dandruff-reducing systems composed of plant-derived active substances have gradually become a research hotspot due to their safety and gentleness. However, problems remain, including large batch-to-batch variations in plant raw materials, unstable content of active ingredients, single target sites, and poor compatibility with surfactants. These problems directly limit their large-scale industrial application. Therefore, developing a safe, gentle, and highly effective oil-controlling and dandruff-removing composition, and achieving oil-controlling and dandruff-removing effects through multiple aspects such as regulating scalp microecology, keratin metabolism, and sebum secretion, has become a technical challenge that urgently needs to be solved in the daily chemical industry. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a composition and application with oil-controlling and dandruff-removing effects.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention provides a composition having oil-controlling and dandruff-removing effects, comprising the following components in parts by weight: 0.5-3 parts of Sapindus mukorossi fruit extract, 0.1-2 parts of Camellia japonica seed extract, 3-6 parts of Artemisia annua extract, 2-5 parts of Forsythia suspensa extract, 0.5-1 part of Terminalia chebula extract, and 2-3 parts of Eclipta prostrata extract.

[0006] Sapindus mukorossi fruit extract is rich in saponins, possessing excellent cleansing and antibacterial properties, making it a low-irritant and gentle care ingredient. Camellia japonica seed extract is high in tea polyphenols and tea seed polysaccharides, which can reduce scalp inflammation and soothe the scalp, relieving itching and reducing dandruff. Artemisia annua extract is rich in artemisinin and various flavonoids, exhibiting broad-spectrum antibacterial and antioxidant properties, improving the scalp microenvironment and reducing dandruff. Forsythia suspensa extract mainly contains forsythosides, forsythosides, forsythoside aglycones, flavonol glycosides, sterols, and strychnine resin glycosides, possessing various pharmacological activities such as antibacterial and anti-inflammatory effects. Terminalia chebula... Chebula extract contains chebulic acid, chebulic acid, gallic acid, and other components, and has antioxidant, antibacterial, and anti-inflammatory activities. Eclipta prostrata extract is an active ingredient extracted from the eclipta prostrata plant (also known as Eclipta prostrata), which is mainly composed of flavonoids, triterpenoids, coumarins, and polysaccharides. It is traditionally used for hemostasis, hair care, and anti-inflammation, and modern research shows that it has potential for antioxidant, immunomodulatory, and liver protection.

[0007] This invention selects six specific plant extracts—Sapindus mukorossi fruit extract, Camellia japonica seed extract, Artemisia annua extract, Forsythia suspensa extract, Terminalia chebula extract, and Eclipta prostrata extract—and combines them in a specific ratio to obtain a composition exhibiting significant 5α-reductase inhibitory activity and Malassezia inhibitory activity, indicating significant oil-controlling, antibacterial, and dandruff-removing effects. Furthermore, in a short period, shampoos prepared using the composition provided by this invention showed significant improvements in scalp oil secretion and dandruff in the subjects. Therefore, the composition provided by this invention is characterized by its gentle yet highly effective oil control and dandruff removal, demonstrating great potential in the application of oil-controlling and dandruff-removing products.

[0008] Further, the composition comprises the following components in parts by weight: 0.5-2 parts of Sapindus mukorossi fruit extract, 0.1-1 parts of Camellia japonica seed extract, 3-5 parts of Artemisia annua extract, 2-3 parts of Forsythia suspensa extract, 0.5-1 parts of Terminalia chebula extract, and 2-2.5 parts of Eclipta prostrata extract.

[0009] Preferably, the composition comprises the following components in parts by weight: 1 part Sapindus mukorossi fruit extract, 0.5 part Camellia japonica seed extract, 4.5 parts Artemisia annua extract, 3 parts Forsythia suspensa extract, 0.5 parts Terminalia chebula extract, and 2 parts Eclipta prostrata extract.

[0010] Furthermore, the preparation method of the Sapindus mukorossi fruit extract is as follows: take dried Sapindus mukorossi fruit, crush it, add water at a mass ratio of 1:6-10, stir and extract at 50-70℃ 2-3 times, each time for 1-3 hours, filter and collect the filtrate, combine the multiple extraction filtrates, concentrate and dry to obtain Sapindus mukorossi fruit extract.

[0011] Preferably, the preparation method of the Sapindus mukorossi fruit extract is as follows: take dried Sapindus mukorossi fruit, crush it through a 150-200 mesh sieve, add water at a mass ratio of 1:8, stir and extract 3 times at 60℃, each time for 1.5h, filter and collect the filtrate, combine the multiple extraction filtrates, concentrate and dry to obtain Sapindus mukorossi fruit extract.

[0012] Furthermore, the preparation method of the camellia seed extract is as follows: after pulverizing dried camellia seeds, add water at a mass ratio of 1:5-20, soak for 2-4 days, extract at 60-90℃ for 30-60 minutes, filter to obtain the filtrate, concentrate and dry to obtain the camellia seed extract.

[0013] Preferably, the preparation method of the camellia seed extract is as follows: dried camellia seeds are crushed and passed through a 50-80 mesh sieve. The sieved camellia seeds are soaked in water at a mass ratio of 1:15 for 3 days to obtain a soaked mixture. The soaked mixture is stirred at 80°C for 45 minutes, filtered to remove residue, concentrated and dried to obtain the camellia seed extract.

[0014] Secondly, the present invention provides the use of any of the above-described compositions in the preparation of cosmetics with oil-controlling and dandruff-removing effects.

[0015] Furthermore, the cosmetic product is a hair care product.

[0016] Preferably, the hair care product is a shampoo.

[0017] Thirdly, the present invention provides a cosmetic product with oil-controlling and dandruff-removing effects, comprising any of the compositions described above.

[0018] Furthermore, the composition accounts for 0.1-10% of the total mass of the cosmetic.

[0019] Preferably, the composition accounts for 3-8% of the total mass of the cosmetic, more preferably 6%.

[0020] Furthermore, the cosmetic product also contains excipients acceptable in the cosmetics industry.

[0021] Furthermore, the excipients include one or more of the following: solvents, penetration enhancers, surfactants, pH adjusters, thickeners, and preservatives.

[0022] Fourthly, the present invention provides an oil-controlling and dandruff-removing shampoo, which, by mass percentage, contains 0.1-10% of the composition described in the first aspect, 10-20% sodium lauryl ether sulfate, 5-10% cocamidopropyl betaine, 1-5% cocamidomethyl MEA, 0.1-2% PPG-octyl ether, 0.1-2.0% panthenol, 0.1-1% allantoin, 0.1-1% polyquaternium-10, 0.1-1% phenoxyethanol, 0.01-2% sodium benzoate, 0.01-2% sodium chloride, 0.01-3% disodium EDTA, and the balance being deionized water.

[0023] Preferably, the oil-controlling and dandruff-reducing shampoo, by mass percentage, contains 6% of the composition described in the first aspect, 15% sodium lauryl ether sulfate, 8.5% cocamidopropyl betaine, 3.5% cocamidomethyl MEA, 1% PPG-octyl ether, 1% panthenol, 0.5% allantoin, 0.4% polyquaternium-10, 0.4% phenoxyethanol, 0.3% sodium benzoate, 0.2% sodium chloride, 0.1% disodium EDTA, and the balance being deionized water.

[0024] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention provides a composition with oil-controlling and dandruff-removing effects, comprising Sapindus mukorossi fruit extract, Camellia japonica seed extract, Artemisia annua extract, Forsythia suspensa extract, Terminalia chebula extract, and Eclipta prostrata extract. Research in this invention shows that the composition, consisting of components in a specific ratio, can synergistically enhance 5α-reductase inhibitory activity and Malassezia inhibitory activity, indicating significant oil-controlling, antibacterial, and dandruff-removing effects. Furthermore, after short-term use of a shampoo prepared from the composition provided by this invention, subjects showed significant improvement in scalp sebum secretion and dandruff. Therefore, the composition provided by this invention can effectively regulate scalp microecology and sebum secretion, significantly reduce dandruff production, and achieve oil-controlling and dandruff-removing effects. Detailed Implementation

[0025] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0026] In the following examples, the preparation method of Sapindus mukorossi fruit extract is as follows: take dried Sapindus mukorossi fruit, crush it and pass it through a 180-mesh sieve, add water at a mass ratio of 1:8, stir and extract 3 times at 60°C, each time for 1.5 hours, filter and collect the filtrate, combine the multiple extraction filtrates, concentrate and dry to obtain Sapindus mukorossi fruit extract.

[0027] The preparation method of camellia seed extract is as follows: dried camellia seeds are crushed and passed through a 60-mesh sieve, water with a mass ratio of 1:15 is added, and the soaking time is 3 days to obtain a soaked mixture; the soaked mixture is heated to 80℃ and the extraction time is 45 minutes, the residue is removed by filtration, and the camellia seed extract is obtained after concentration and drying.

[0028] Artemisia annua extract was purchased from Mujiuye (Shanghai) Technology Co., Ltd.; Forsythia suspensa extract was purchased from Huzhou Anran Biotechnology Co., Ltd. Terminalia chebula extract was purchased from Huzhou Anran Biotechnology Co., Ltd. Eclipta prostrata extract was purchased from Huzhou Anran Biotechnology Co., Ltd.

[0029] Unless otherwise specified, all other materials and reagents used in the examples are commercially available.

[0030] Examples 1-4 and Comparative Examples 1-4 (1) Preparation of the composition According to the formula in Table 1, each component was weighed according to the corresponding weight to prepare the compositions of Examples 1-4 and Comparative Examples 1-4.

[0031] Table 1. Component composition and weight parts of the composition

[0032] Note: "-" indicates that the component is not added, and the total mass of the compositions in different examples and comparative examples is the same.

[0033] (2) In vitro efficacy verification 1. Assay for inhibition of 5α-reductase activity Test principle: Seborrhea is caused by excessive sebum secretion due to dysfunction of the sebaceous glands. Excessive sebum secretion also easily leads to excessive dandruff on the scalp. Sebum secretion is related to increased androgen levels. The androgen-metabolizing enzyme 5α-reductase, with the participation of NADPH, can convert testosterone into dihydrotestosterone, which has a stronger binding activity to androgen receptors, thereby promoting sebum secretion. Its activity affects the amount of sebum secreted. Therefore, the oil-controlling effect of the composition provided by this invention can be judged by the inhibition rate of 5α-reductase on the composition sample; the higher the inhibition rate, the stronger the oil-controlling effect, and vice versa.

[0034] Test method: Testosterone was used as the substrate, and finasteride as the positive control. The change in testosterone concentration before and after the reaction was measured to determine the inhibition rate of the composition on 5α-reductase. The specific method is as follows: Reaction system: The compositions of Examples 1-4 and Comparative Examples 1-4 were prepared as test samples with a mass concentration of 10%. 0.5 mL of phosphate buffer, 0.2 mL of the test sample, 200 μL of 300 mg / L testosterone solution, and 200 μL of 0.8 g / L NADPH (reduced coenzyme II) solution were added sequentially to a stoppered test tube. Finally, 0.5 mL of the 5α-reductase extract prepared above was added, and the reaction was carried out at 37 °C for 30 min. Reference settings: Positive control: 0.05 mg / L finasteride solution was used as a substitute for the test sample; Enzyme reaction tubes: contain only enzyme extract and substrate (without test sample); Blank tube: Enzyme-free extract (replaced with an equal volume of buffer).

[0035] Detection method: After the reaction was completed, 3 mL of dichloromethane was added to stop the reaction and extract testosterone. Then, 0.25 mL of 100 mg / L propylparaben was added as an internal standard, and the mixture was centrifuged at 5000 r / min for 10 min. The upper aqueous phase was discarded, and about 1 mL of the organic phase was transferred, evaporated to dryness, and the residue was dissolved in 1.5 mL of methanol. 10 μL of the solution was then used to determine the residual testosterone content by high performance liquid chromatography.

[0036] High performance liquid chromatography (HPLC) analysis of testosterone concentration changes before and after the reaction: a C18 reversed-phase column (4.6 × 250 mm, 5 μm) was used for detection; the mobile phase was methanol / water (70:30, v / v); the flow rate was 1.0 mL / min; the detection wavelength was 254 nm; and the injection volume was 10 μL.

[0037] The 5α-reductase inhibition rate was calculated using the following formula: ; In the formula: C is the ratio of the peak area of ​​testosterone to the peak area of ​​the internal standard.

[0038] 2. Antibacterial efficacy determination Test Principle: Skin microbiome research indicates that Malassezia is considered a key factor in exacerbating dandruff, commonly found in areas rich in sebaceous glands such as the scalp, face, chest, and back. Furthermore, when Malassezia proliferates on the scalp, it stimulates sebaceous glands to secrete more sebum and damages the scalp's barrier function, making the scalp more susceptible to infection by other bacteria and fungi, thus worsening oily scalp and dandruff problems. Therefore, measuring the inhibitory effect of the composition on Malassezia can determine the composition's oil-controlling and dandruff-reducing effects.

[0039] Test method: The compositions of Examples 1-4 and Comparative Examples 1-4 were prepared as test samples with a mass concentration of 10%, and the antibacterial effect was tested by the inhibition zone method: the culture medium used was agar medium, and the test strain was the standard strain of Malassezia furfur.

[0040] Experimental procedure: Prepare bacterial suspension with a concentration of 10. 6 A suspension of approximately CFU / ml of Malassezia furfur was evenly spread onto Leeming & Notman agar plates, which were then placed in a sterile operating table to air dry. Test samples were quantitatively added to these plates and incubated at 30°C for 7 days. The results were observed and recorded as the diameter of the inhibition zone, and the mean was calculated (three replicates were performed for each sample group).

[0041] The efficacy test results are shown in Table 2. Regarding the 5α-reductase inhibitory activity: the compositions of Examples 1-4 showed an inhibition rate of 68.3%-76.1% on 5α-reductase, with Example 2 showing the best effect, close to that of the positive control group, indicating that the composition provided by the present invention has significant oil-controlling efficacy. Comparing Example 2 with Comparative Examples 1-4, it can be seen that when the composition lacks Forsythia suspensa extract and / or Terminalia chebula extract, the inhibitory effect of the composition on 5α-reductase is significantly reduced, indicating that Forsythia suspensa extract, Terminalia chebula extract, Sapindus mukorossi fruit extract, Camellia japonica seed extract, Artemisia annua extract, and Eclipta prostrata extract have a synergistic effect; at the same time, the weight ratio of each component in the composition also has an important influence on its 5α-reductase inhibitory activity, thus affecting its oil-controlling effect.

[0042] Regarding the antibacterial effect: The results show that, compared with the comparative examples, the diameter of the inhibition zone of the composition provided in the examples increased by 7.3-17.7 mm, indicating that the composition provided by the present invention has a significantly enhanced inhibitory effect on the growth of Malassezia furfur. Comparing Example 2 with Comparative Examples 1-4 shows that the combination of components in the composition can synergistically improve the inhibitory effect of the composition on the growth of Malassezia, and the ratio of components in the composition also has a significant impact on the antibacterial effect on Malassezia.

[0043] In summary, the composition provided by this invention has significant inhibitory effects on 5α-reductase and Malassezia growth, indicating that it can effectively reduce scalp sebum secretion and dandruff production.

[0044] Table 2 Results of Composition Efficacy Tests Group 5α-Reductase Inhibition Rate (%) Diameter of the inhibition zone (mm) Positive control 85.6 - Example 1 72.4 27.1 Example 2 76.1 29.6 Example 3 73.7 26.3 Example 4 68.3 24.5 Comparative Example 1 50.2 15.4 Comparative Example 2 41.5 17.2 Comparative Example 3 47.1 11.9 Comparative Example 4 53.8 12.7 Application Example 1-4 and Comparative Application Example 1-4 The compositions of Examples 1-4 and Comparative Examples 1-4 were used to prepare shampoos. The shampoos were prepared according to the formulations in Table 3. The preparation methods were carried out in accordance with conventional preparation methods in the art, and the shampoos of Application Examples 1-4 and Comparative Application Examples 1-4 were obtained respectively.

[0045] Table 3 Shampoo Composition and Dosage Components Quality score (%) Deionized water Make up to 100% Examples / Comparative Compositions 6 Sodium lauryl ether sulfate 15 Cocamidopropyl Betaine 8.5 Cocamide methyl MEA 3.5 PPG-Octoether 1.0 Panthenol 1.0 Allantoin 0.5 Polyquaternium-10 0.4 Phenoxyethanol 0.4 Sodium benzoate 0.3 Sodium chloride 0.2 Disodium EDTA 0.1 Effect evaluation: Eighty volunteers with oily scalps and dandruff were selected and divided into eight groups. Each group used the shampoos provided in Examples 1-4 and the control examples 1-4, respectively. A two-week shampooing period was established before the volunteers used the test samples to avoid the influence of their original shampoo products depositing on their hair and scalp. After the shampooing period, the shampoo provided by this invention was used for testing. The method of use is as follows: After wetting hair, take 5mL of shampoo, lather it up, and apply it evenly to the hair and scalp. Then, massage in circular motions with your fingertips, gently massaging from the roots to the ends for 3-5 minutes, and then rinse thoroughly with water. Use once every other day, and follow-up visits were conducted before and two weeks after use.

[0046] Test metrics: Oil control efficacy indicators: Before and two weeks after use, the amount of sebum secreted on the scalp of volunteers was measured using a sebum analyzer (Sebumeter SM815). During the test, subjects were required to refrain from washing their hair for 24 hours prior to the follow-up. After arriving at the testing laboratory, subjects were required to sit quietly in the testing environment for 30 minutes before the test. The test results were characterized by the rate of reduction in scalp sebum secretion, which was calculated using the following formula: Reduced scalp sebum secretion rate (%) = [(Scalp sebum secretion before use - Scalp sebum secretion after 2 weeks of use) / Scalp sebum secretion before use] × 100%.

[0047] Dandruff Reduction Indicators: Dandruff levels were assessed in subjects before and 2 weeks after use using the ASFS score (adherent scalp flaking score), as shown in Table 4. During the test, subjects were required to refrain from washing their hair for 24 hours prior to the follow-up. Upon arrival at the testing laboratory, subjects were required to sit quietly in the testing environment for 30 minutes, during which time they were not allowed to scratch or touch their heads. Professional testers assessed the volunteers' dandruff levels, recorded the ASFS scores, and calculated the dandruff improvement rate using the following formula: Dandruff Improvement Rate (%) = [(ASFS score before use - ASFS score after 2 weeks of use) / ASFS score before use] × 100%.

[0048] Table 4 ASFS Score Scoring Criteria Rating describe 0 No visible desquamation 1 Occasionally, fine, slight peeling may be observed. 2 Fine flakes of hair are visible at the hair roots 3 Small amounts of large flakes or large amounts of small flakes on the scalp and head 4 Large amounts of large-scale shedding The test results are shown in Table 5. The results indicate that using the shampoo prepared with the composition of this invention effectively reduced scalp oil secretion and improved dandruff. After two weeks of use, scalp oil decreased by 33.7-38.9%, and dandruff production decreased by 34.3-45.2%, demonstrating that short-term use of the shampoo provided by this invention significantly improved scalp oil secretion and dandruff production. Comparing the results of Application Example 2 with Comparative Application Examples 1-4 shows that the component composition and proportions of the composition of this invention have a significant impact on improving the oil-controlling and dandruff-removing effects of the shampoo.

[0049] Table 5 Evaluation results of the oil control and dandruff removal effects of the composition Group Scalp sebum secretion reduction rate (%) Dandruff improvement rate (%) Application Example 1 35.1 38.4 Application Example 2 38.9 45.2 Application Example 3 37.4 36.9 Application Example 4 33.7 34.3 Comparative Application Example 1 25.8 16.7 Comparative Application Example 2 21.3 18.6 Comparative Application Example 3 22.5 13.5 Comparative Application Example 4 26.2 14.0 The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. A composition having oil-controlling and dandruff-removing effects, characterized in that, It includes the following components in parts by weight: 0.5-3 parts of Sapindus mukorossi fruit extract, 0.1-2 parts of Camellia japonica seed extract, 3-6 parts of Artemisia annua extract, 2-5 parts of Forsythia suspensa extract, 0.5-1 part of Terminalia chebula extract, and 2-3 parts of Eclipta prostrata extract.

2. The composition according to claim 1, characterized in that, The product contains the following components in parts by weight: 0.5-2 parts of Sapindus mukorossi fruit extract, 0.1-1 parts of Camellia japonica seed extract, 3-5 parts of Artemisia annua extract, 2-3 parts of Forsythia suspensa extract, 0.5-1 parts of Terminalia chebula extract, and 2-2.5 parts of Eclipta prostrata extract.

3. The composition according to claim 1, characterized in that, The preparation method of the Sapindus mukorossi fruit extract is as follows: take dried Sapindus mukorossi fruit, crush it, add water at a mass ratio of 1:6-10, stir and extract at 50-70℃ 2-3 times, each time for 1-3 hours, filter and collect the filtrate, combine the multiple extraction filtrates, concentrate and dry to obtain Sapindus mukorossi fruit extract.

4. The composition according to claim 1, characterized in that, The preparation method of the camellia seed extract is as follows: after pulverizing dried camellia seeds, add water at a mass ratio of 1:5-20, soak for 2-4 days, extract at 60-90℃ for 30-60 minutes, filter to obtain the filtrate, concentrate and dry to obtain the camellia seed extract.

5. The use of the composition according to any one of claims 1-4 in the preparation of cosmetics with oil-controlling and dandruff-removing effects.

6. The application as described in claim 5, characterized in that, The cosmetic product in question is a hair care product.

7. A cosmetic product with oil-controlling and dandruff-removing effects, characterized in that, Contains the composition according to any one of claims 1-4.

8. The cosmetic product as described in claim 7, characterized in that, The composition accounts for 0.1-10% of the total mass of the cosmetic.

9. The cosmetic product as described in claim 7, characterized in that, The cosmetics also contain excipients acceptable in the cosmetics industry.

10. The cosmetic product as described in claim 9, characterized in that, The excipients include one or more of the following: solvents, penetration enhancers, surfactants, pH adjusters, thickeners, and preservatives.

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