Cosmetic composition for enhancing exfoliation

Abstract

To provide cosmetics which fully exhibit the effect of increasing corneum exfoliation and are free of irritation.SOLUTION: The present invention relates to a cosmetic composition for increasing corneum exfoliation containing serine or carnitine, which contains substantially no humectant ingredient with a polyol group or contains such a humectant ingredient at a concentration equal to or lower than a predetermined level.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a cosmetic composition for enhancing exfoliation.

[0002] This application claims priority based on Korean Patent Application No. 10-2018-0083069 filed on July 17, 2018, and Korean Patent Application No. 10-2019-0063704 filed on May 30, 2019, and the contents disclosed in the specifications and drawings of those applications are incorporated herein in their entirety. [Background technology]

[0003] The stratum corneum is the outermost layer of the skin and is composed of large, lamellar lipid layers containing keratinocytes and ceramides. The stratum corneum protects against external substances and functions as a barrier to prevent moisture loss from the interior. A normal stratum corneum consists of approximately 15 to 20 layers. The action of serine proteases activated on the outer surface of the stratum corneum causes the degradation of coniodesmosomes, eventually resulting in the stratum corneum's complete detachment from the skin. This process takes approximately 15 to 20 days for normal cells. In addition to genetic disorders such as ichthyosis, aging, psoriasis, and acne-prone skin can also cause the stratum corneum to thicken, resulting in keratinocyte stratification.

[0004] Stratification of the stratum corneum is generally known to be induced by factors such as a decrease in skin moisture retention, a decrease in the expression or activity of serine proteases, ultraviolet rays, and decreased cell activity. To resolve this stratification, methods such as physical exfoliation using scrubs, exfoliation using chemical preparations, and increased physiological cell activity are typically used. These exfoliation methods aim to resolve appearance problems such as rough skin and dullness by artificially removing outer keratinocytes and replacing the outermost stratum corneum with new keratinocytes from the inside, thereby eliminating keratinocyte stratification.

[0005] The reduction of stratum corneum stratification through enhanced exfoliation also provides additional benefits, such as the removal of fine wrinkles and dark spots and the improvement of rough skin, and is therefore utilized in a variety of products. Alpha hydroxy acid (AHA), beta hydroxy acid (BHA), and polyhydroxy acid (PHA) are typically used. However, the mode of action of AHA, BHA, and PHA is to penetrate the stratum corneum and release hydrogen ions, weakening coniodesmosome bonds and resulting in exfoliation. A low pH is essential for easy penetration into the stratum corneum and high hydrogen ion transfer when applied at low pH. Therefore, low pH can cause side effects such as stinging, itching, and erythema, and research is underway to overcome these side effects. However, when the pH is adjusted to a weakly acidic to neutral range to mitigate the side effects of such skin irritation, the activity is reduced by more than 80%. Furthermore, when the agent undergoes chemical transformation, the efficacy is offset, making it difficult to obtain the substantial benefits of exfoliation. Therefore, there is a growing need for new exfoliants that exhibit exfoliating efficacy similar to that of AHA under acidic conditions even at a weakly acidic or neutral range.

[0006] Therefore, the inventors of the present invention have identified a composition containing serine and carnitine in Korean Patent Application No. 10-2017-0165268 based on their previous research, which shows efficacy greater than that of AHA at the same concentration under neutral or weakly acidic conditions, and have confirmed that it causes relatively little or no irritation, and have provided it as an excellent new exfoliating material. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Korean Patent Application No. 10-2018-0083069 [Patent Document 2] Korean Patent Application No. 10-2019-0063704 Summary of the Invention [Problem to be solved by the invention]

[0008] The present invention aims to provide a cosmetic composition that selects a composition that maintains the accessibility of the exfoliating agent to keratinocyte-binding proteins, thereby fully demonstrating the added effect of enhancing exfoliation of keratin and causing no irritation.

[0009] Another object of the present invention is to solve the problem of reduced exfoliating efficacy when serine or carnitine, which has superior exfoliating efficacy at weakly acidic to neutral pH levels compared to existing raw materials, is actually applied to cosmetic formulations.

[0010] More specifically, the present invention aims to provide a cosmetic composition for enhancing exfoliation that contains serine or carnitine and is substantially free of moisturizing ingredients having polyol groups or contains them at a certain concentration or less. [Means for solving the problem]

[0011] In order to achieve the above object, the present invention provides a cosmetic composition for enhancing exfoliation of skin, which contains an exfoliating agent and is free of a polyol moisturizing agent or contains a polyol moisturizing agent in an amount of 10 wt% or less based on the total weight of the composition.

[0012] According to one aspect of the present invention, the exfoliating agent of the cosmetic composition for enhancing exfoliation of the present invention is one or more of serine and carnitine.

[0013] According to one aspect of the invention, the polyol moisturizer of the cosmetic composition for enhancing exfoliation of keratinized skin of the present invention is at least one selected from the group consisting of glycerin, dipropylene glycol, butylene glycol, glycereth-26, methyl gluceth-20, and pentylene glycol.

[0014] According to one aspect of the present invention, the exfoliating agent in the cosmetic composition for enhancing exfoliation of the present invention is contained in an amount of 0.001 to 20% by weight based on the total weight of the composition.

[0015] According to one aspect of the present invention, the cosmetic composition for enhancing exfoliation of the present invention is free of polyol moisturizers or contains no more than 10% by weight of the polyol moisturizers relative to the total weight of the composition.

[0016] According to one embodiment of the present invention, the cosmetic composition for enhancing keratin exfoliation of the present invention has a pH of 5-8. [Effects of the Invention]

[0017] The present invention provides a cosmetic composition for exfoliating skin containing serine or carnitine, which provides superior exfoliating effects at a weakly acidic to neutral pH without irritation compared to existing ingredients, by maintaining the accessibility of the exfoliating agent to stratum corneum-binding proteins, thereby enabling the effective enhancement of exfoliation. The exfoliating effect of serine or carnitine is maintained without any reduction. [Brief explanation of the drawings]

[0018] [Figure 1] This shows the results of evaluation of exfoliation of pig skin keratin using a combination of 5% serine and glycerin. [Figure 2] This shows the results of an evaluation of the exfoliation of pig skin using a combination of 5% carnitine and glycerin. [Figure 3]1 shows the results of evaluation of exfoliation of pig skin using a combination of serine with glycerin, dipropylene glycol, and 1,3-butylene glycol. [Figure 4] This shows the results of an evaluation of exfoliation of pig skin keratin using a combination of a 5% serine solution and various concentrations of DPG. [Figure 5] This shows the results of an evaluation of the exfoliation of pig skin using a combination of carnitine with glycerin, dipropylene glycol, and 1,3-butylene glycol. [Figure 6] The results confirmed that the combined use of moisturizers inhibits the exfoliating effect. [Figure 7] This is a relative comparison value of the exfoliating ability of keratin depending on the combined concentration of serine and glycerin. [Figure 8] This is the result of measuring the relative comparative value of exfoliating ability for a combination of carnitine (5%) and glycerin. [Figure 9] The results of measuring the relative exfoliating ability of a combination of serine (5%) and glycerin. [Figure 10] This shows the results of measuring the relative comparative value of exfoliating ability for a combination of carnitine (0.5%) and glycerin. [Figure 11] The results show the relative comparative values of exfoliating ability of keratin in a combination of serine (0.5%) and glycerin. [Figure 12] Photographs showing changes after 10 days of an experiment using DHA staining method. [Figure 13] This is the result of TT100% measurement using a combination of serine and glycerin. DETAILED DESCRIPTION OF THE INVENTION

[0019] To achieve the above object, the present invention provides a cosmetic composition for enhancing exfoliation of skin, which contains an exfoliating agent and is free of a polyol moisturizing agent or contains a polyol moisturizing agent in an amount of 10 wt% or less based on the total weight of the composition. The present invention will now be described in detail with reference to the drawings.

[0020] The present inventors attempted to produce commercially available cosmetics that have exfoliation-enhancing properties by incorporating an exfoliant into a cosmetic composition containing various additives such as surfactants, fragrances, preservatives, humectants, thickeners, and antioxidants. However, they found that the exfoliation-enhancing efficiency was significantly lower than expected depending on the concentration of the exfoliant. During their research, they discovered that the cause of the reduced exfoliation function was moisturizing ingredients among various cosmetic additives, particularly moisturizing ingredients with polyol groups, which reduced the accessibility of the exfoliating ingredients to the keratin-binding proteins. As a result, the exfoliation ability was reduced because the exfoliating ingredients did not affect the keratin-binding proteins. They proposed a solution to this problem, leading to the completion of the present invention.

[0021] The present invention provides a cosmetic composition that allows an exfoliant, particularly serine or carnitine, to maintain its effectiveness. More specifically, the present invention aims to provide a serine or carnitine cosmetic that provides superior exfoliation effects at a weakly acidic to neutral pH without irritation compared to existing ingredients.

[0022] However, when this formulation is used, the exfoliating effect of serine or carnitine is reduced. Therefore, the present invention has found that the exfoliating effect of serine or carnitine is rapidly reduced when serine or carnitine contains a polyol-containing moisturizer, such as one or more polyols such as glycerin, dipropylene glycol (DPG), and 1,3-butylene glycol (BG), at a concentration above a certain level. Therefore, the present invention provides serine or carnitine that is substantially free of polyol moisturizer components or does not significantly reduce their effectiveness.

[0023] In one embodiment, the present invention provides a cosmetic composition for enhancing skin exfoliation, comprising an exfoliating agent and being substantially free of a polyol moisturizer.

[0024] As used herein, the term "substantially free" means that the composition contains no more than 2% by weight, preferably no more than 1% by weight, more preferably no more than 0.5% by weight, even more preferably no more than 0.3% by weight, even more preferably no more than 0.1% by weight, and most preferably no content whatsoever, based on the total weight of the composition.

[0025] Meanwhile, moisturizers having polyol groups are as commonly used as purified water in cosmetic compositions, and in particular, in the case of exfoliating products, moisturizing is required more than usual, so it is an issue to provide a cosmetic composition for enhancing exfoliation that contains a polyol moisturizer.

[0026] Therefore, in another embodiment, the present invention provides a cosmetic composition for enhancing exfoliation of skin, comprising an exfoliant and a polyol moisturizer. When the composition of the present invention comprises the polyol moisturizer, the content is from more than 0 to 10 wt%, preferably from more than 0 to 2 wt%, and more preferably from more than 0 to 0.5 wt%. The content range of the polyol moisturizer is critical because the exfoliation effect is significantly reduced when the content is outside this range.

[0027] As used herein, the term "exfoliation" refers to the sloughing or removal of keratinocytes from the stratum corneum of the skin. This concept includes not only removal by applying a physical force, but also removal from the stratum corneum of the skin solely by applying a cosmetic composition without applying any other force.

[0028] According to one aspect of the present invention, the exfoliating agent of the cosmetic composition for enhancing exfoliation of the present invention may be one or more of serine and carnitine.

[0029] According to one aspect of the present invention, the exfoliant in the cosmetic composition for enhancing exfoliation of keratinocytes of the present invention may be contained in an amount of 0.001 to 20 wt. % of the total weight of the composition, preferably 0.01 to 17 wt. %, and more preferably 0.05 to 15 wt. If the amount is less than 0.001 wt. %, it may be difficult to achieve the desired effect, and if the amount exceeds 20 wt. %, the effect of the increased amount may be insignificant.

[0030] According to one aspect of the present invention, the polyol moisturizer in the cosmetic composition for enhancing exfoliation of keratin may be at least one selected from the group consisting of glycerin, dipropylene glycol (DPG), butylene glycol (BG), glycereth-26, methyl gluceth-20, and pentylene glycol. Specifically, it may be at least one selected from the group consisting of glycerin, dipropylene glycol, and 1,3-butylene glycol.

[0031] According to one aspect of the present invention, the cosmetic composition for enhancing exfoliation of the present invention may contain no polyol moisturizer or may contain no more than 10% by weight, preferably no more than 5% by weight, more preferably no more than 2% by weight, even more preferably no more than 1% by weight, even more preferably no more than 0.5% by weight, even more preferably no more than 0.3% by weight, and even more preferably no more than 0.1% by weight, based on the total weight of the composition. If the content is greater than 10% by weight, it is difficult to achieve the desired exfoliating effect of the exfoliant.

[0032] According to one aspect of the present invention, the cosmetic composition for enhancing exfoliation of the present invention may have a pH of 5-8, preferably a pH of 5-7.5, and more preferably a pH of 5.5-7.

[0033] In addition to the above-mentioned components, the cosmetic composition for enhancing keratin exfoliation of the present invention may further contain components typically contained in cosmetics, selected as desired depending on the formulation or intended use of the cosmetic. Furthermore, the composition of each formulation may contain various bases and additives necessary and appropriate for formulating that formulation, and may contain known compounds such as preservatives, thickeners, surfactants, silicone polymers, oxidizing agents, organic solvents, antioxidants, emollients, colorants, and fragrances, within the range that does not reduce the effects of the formulation.

[0034] It was confirmed through a screening method using a pig skin exfoliation evaluation method and a human test method using a DHA staining method that the cosmetic composition according to the present invention exhibits excellent exfoliating effect among formulations containing moisturizers with polyols.

[0035] Specifically, using a pig skin exfoliation evaluation method, it was confirmed that the activity of serine or carnitine in the neutral or weakly acidic pH range of 5-7 is equal to or greater than that of gluconolactone (PHA) or lactic acid (AHA) at pH 4, and the effects were confirmed by combining different polyol moisturizer ingredients by material and concentration.

[0036] When the exfoliating effect of a cosmetic composition containing serine or carnitine and the polyol moisturizer components glycerin, dipropylene glycol, and 1,3-butylene glycol was evaluated using a pig skin exfoliation evaluation method, the exfoliating effect rapidly decreased when the polyol moisturizer content was 0.1 wt% or more, and when it exceeded 10 wt%, the exfoliating effect was zero, as was the negative control group (water), meaning that the exfoliating effect was not significantly demonstrated even in human tests.

[0037] In addition, the exfoliating effect of a cosmetic composition containing serine or carnitine and polyol moisturizer ingredients glycerin, dipropylene glycol, and 1,3-butylene glycol was evaluated in a human test using DHA staining. As a result, when the polyol moisturizer content was 10% or 50%, the number of days for keratin turnover (TT100) was not significantly different from 20 days without application. However, it was confirmed that the cosmetic composition for enhancing exfoliation of the present invention reduced the number of days for keratin turnover to 17 days or less, preferably 14 days, compared to 20 days without application.

[0038] Therefore, the present invention provides exfoliating agents such as serine or carnitine that are substantially free of polyol moisturizers, or that do not significantly reduce their effectiveness, because the activity of these agents is reduced to an insignificant level by the polyol moisturizers glycerin, dipropylene glycol, and 1,3-butylene glycol. In other words, the exfoliating composition used in the present invention includes serine or carnitine, and is substantially free of one or more of the polyol moisturizers glycerin, dipropylene glycol, and 1,3-butylene glycol, or that are selected from a range that does not significantly reduce their effectiveness.

[0039] The present invention will be described in more detail below with reference to examples, but these examples are merely for the purpose of explaining the present invention in more detail and are not intended to limit the scope of the present invention.

[0040] 1. Combination configuration For the purpose of experiments to confirm the effects of the present invention, combinations of serine or carnitine and moisturizing ingredients having a polyol group were prepared as shown in Table 1 below.

[0041] [Table 1]

[0042] Example 1. Evaluation of exfoliation of pig skin Existing clinical evaluation methods are time-consuming and difficult to conduct experiments on all the different concentrations and pH conditions of various raw materials. In addition, it is difficult to conduct experiments on all the possible compositions that can be combined with each raw material. Therefore, there is a growing need for non-clinical methods for evaluating exfoliation.

[0043] Therefore, in the present invention, the keratin peeling evaluation method described in Journal of the European Academy of Dermatology and Venereology, 2014, 28, 415-423 was used. Specifically, pig skin was biopsied and the sample to be tested was added. The number of keratin layers that were removed was then measured using a cell counter, and the results were plotted using a sample containing only water as the negative control (0%) and 10% gluconolactone (pH 4) as the positive control (100%).

[0044] (1) Glycerin was added to a 5% serine solution in various combinations (combinations A and B) as shown in Table 2 below, and the experimental results are shown in Figure 1.

[0045] [Table 2]

[0046] The experimental results showed that the efficacy of serine decreased rapidly with the addition of glycerin, reaching a range below 0% where no efficacy was observed at concentrations above 10%. This confirmed that the efficacy of serine decreased with increasing glycerin concentration, and that glycerin must be used at a concentration of 10% or less to be effective as an exfoliant (Figure 1).

[0047] (2) A 5% carnitine solution was combined with glycerin in various combinations (combinations E and F) as shown in Table 3 below, and the results of the exfoliation experiment on pig skin are shown in Figure 2.

[0048] [Table 3]

[0049] The experimental results showed that the exfoliating effect decreased sharply above 5% glycerin, and above 10% by weight, the exfoliating effect was reduced to below that of water (the negative control), confirming that there was no exfoliating effect (Figure 2).

[0050] (3) The results of the compositions containing 5% serine, 10% glycerin, 12% dipropylene glycol, and 1,3-butylene glycol (Table 4; Combinations A, B, C, and D) are shown in Figure 3. The experimental results for Combination D, in which DPG was added to a 5% serine solution at various concentrations, are shown in Figure 4.

[0051] [Table 4]

[0052] The experimental results confirmed that the exfoliating effect of dipropylene glycol and 1,3-butylene glycol, like glycerin, was reduced. Therefore, when dipropylene glycol and 1,3-butylene glycol were combined at concentrations exceeding 10%, the exfoliating activity was reduced to below that of the negative control (water), and no significant difference was observed compared to the non-applied group. Therefore, it was further confirmed that, when combined with serine, one or more of glycerin, dipropylene glycol, and 1,3-butylene glycol, which are moisturizers having a polyol group, exhibit exfoliating effect at concentrations of 10% or less (Figures 3 and 4).

[0053] (4) The results of the compositions containing 5% carnitine, 10% glycerin, 12% dipropylene glycol, and 1,3-butylene glycol (combinations E, F, G, and H) are shown in FIG.

[0054] [Table 5]

[0055] The experimental results showed that even in the case of carnitine, when glycerin, dipropylene glycol, and 1,3-butylene glycol were added, the exfoliating activity of the skin was reduced to an extent that was insignificant in human trials (Figure 5).

[0056] (5) Furthermore, the results for the combination (combination I) in which a moisturizing agent mixture (glycerin:DPG:1,3-BG=1:1:1) was added to a 5% serine solution are shown in Figure 6.

[0057] This confirmed that the exfoliating efficacy of exfoliants containing glycerin, dipropylene glycol, and 1,3-butylene glycol decreased similarly when used alone.In other words, even when a mixture of moisturizers containing polyol groups was included, exfoliating efficacy was confirmed at concentrations of 10% or less (Figure 6).

[0058] Therefore, when one or more moisturizers having a polyol group, selected from glycerin, dipropylene glycol, and 1,3-butylene glycol, are included in a range of 10% by weight or less in combination with serine or carnitine, they exhibit exfoliating effects. Therefore, when such moisturizer components are substantially absent or used at a specific concentration or less, preferably 10% by weight or less, a significant exfoliating effect can be achieved.

[0059] (6) In addition, the concentration of serine was changed to 0.5% serine experimental group and 5% serine experimental group. The results of the comparison of the reduction in exfoliating efficacy depending on the concentration of glycerin are shown in Figure 7. The results are calculated by using serine alone as the positive control (100%).

[0060] The experimental results showed that the exfoliating efficacy level decreased in a similar manner as the glycerin concentration increased in both the 0.5% serine experimental group (dashed line in Figure 7) and the 5% serine experimental group (solid line in Figure 7). This confirmed that, regardless of the concentration of serine or carnitine, the concentration of moisturizing ingredients having polyol groups in the composition plays a major role in reducing exfoliating efficacy. This means that it is desirable for serine or carnitine to be substantially free of moisturizing ingredients having polyol groups or to contain them at a specific concentration, preferably 10% or less.

[0061] Taking the above results together, it was confirmed that the exfoliating ability of serine and carnitine depends on the concentration of the moisturizers having polyol groups, namely glycerin, dipropylene glycol, and 1,3-butylene glycol, and that the effects noticeable to the user are achieved when the moisturizer components having polyol groups are used in a concentration of substantially no amount or less than 10%.

[0062] (7) In the combination of carnitine (5%) and glycerin, an experiment was conducted to measure the relative comparative values of exfoliating ability by further dividing the concentration of glycerin. The results are shown in Table 6 below and FIG. 8.

[0063] [Table 6]

[0064] The experimental results showed that when the glycerin content was doubled from 1 wt% to 2 wt%, the exfoliating ability remained almost the same, but when the glycerin content was increased to 3 wt%, the exfoliating ability significantly decreased.In addition, when the glycerin content was increased five-fold from 0.1 wt% to 0.5 wt%, the exfoliating ability actually increased, but when the glycerin content was increased to 1 wt%, the exfoliating ability significantly decreased, confirming the critical significance of the content range.

[0065] (8) In a combination of serine (5%) and glycerin, an experiment was conducted to measure the relative comparative values of exfoliating ability by further dividing the concentration of glycerin, and the results are shown in Table 7 and FIG. 9 below.

[0066] [Table 7]

[0067] The experimental results showed that when the glycerin content was doubled from 1 wt% to 2 wt%, the exfoliating ability remained almost the same, but when the glycerin content was increased to 3 wt%, the exfoliating ability significantly decreased.In addition, when the glycerin content was increased five-fold from 0.1 wt% to 0.5 wt%, the exfoliating ability actually increased, but when the glycerin content was increased to 1 wt%, the exfoliating ability significantly decreased, confirming the critical significance of the content range.

[0068] (9) In the case of carnitine (0.5%), to determine how the inhibition of exfoliating ability due to the polyol combination changes compared to the existing 5% concentration, an experiment was conducted to measure the relative comparison value of exfoliating ability by subdividing the glycerin concentration. The results are shown in Table 8 and FIG. 10 below.

[0069] [Table 8]

[0070] The experimental results showed that when the glycerin content was 0.5 wt%, it showed excellent exfoliating ability comparable to that of a glycerin-free product, but when the glycerin content was increased to 1 wt%, the exfoliating ability significantly decreased, confirming the critical significance of the content range.

[0071] (10) In the case of serine (0.5%), in order to confirm how the inhibition of exfoliating ability due to the combination of polyols changes compared to the existing 5% concentration, an experiment was conducted to measure the relative comparison value of exfoliating ability by subdividing the concentration of glycerin. The results are shown in Table 9 and FIG. 11 below.

[0072] [Table 9]

[0073] The experimental results showed that when the glycerin content was 0.5 wt%, the exfoliating ability was excellent, comparable to that of a glycerin-free product. However, when the glycerin content was increased to 1 wt%, the exfoliating ability significantly decreased, confirming the critical significance of the content range.

[0074] Example 2. Method for evaluating the promotion of keratin turnover using the DHA staining method The DHA staining method for assessing keratin turnover rate was performed on 10 healthy male subjects aged 20-40 years using the method described in Dermatology 1993, 186, 133-137. Before application of the sample, the color of the inner lower and upper arm regions of the subjects was measured using a chroma meter. Approximately 0.4 ml of 10% dihydroxyacetone (DHA) was applied to a 1.5 x 1.5 cm gauze pad and applied to the inner upper and lower arm regions for 8 hours. After 48 hours, the color of the brown areas stained by DHA was measured and compared with the color before sample application. The sample was then applied twice daily, and the degree of depigmentation was measured using a chroma meter. The time required for the skin to return to its original color was also measured. TT (Turnover Time) 100% refers to the time it takes for the existing stratum corneum to be 100% replaced with new stratum corneum, and in this experiment, the time it takes for skin pigmented by DHA to return to its original state was calculated using a relative comparison analysis with regression analysis. The results for the negative control group were calculated on the 20th day, and the relative values were compared.

[0075] The results for the untreated group were calculated on the 20th day, and the visual changes that appeared 10 days after application are shown in Figure 12. Visual observation showed no significant difference between the untreated group and the 10% or 50% glycerin concentration groups, and it was confirmed that when glycerin was used alone, both the 0.5% and 5% concentrations were effective.

[0076] When this was converted into quantitative values using a Chromameter, the results were as shown in Figure 13. When 5% glycerin was used, it was confirmed that TT100% decreased by about 6 days from 20 days without application to 14 days, and when the glycerin concentration was 10% or 50%, there was no significant change compared to the non-application group.

[0077] None of the combination groups experienced any side effects such as erythema, itchiness, or pain after the experimental period. Therefore, the inhibition of exfoliating activity within the concentration range selected by the pig skin exfoliation evaluation method was also confirmed in human experiments. In conclusion, it was confirmed that the exfoliating effect of serine or carnitine can be achieved by using polyol-containing moisturizers, such as glycerin, dipropylene glycol, and 1,3-butylene glycol, either without substantial use or at a specific concentration of 10% or less, at a level that enhances exfoliation that can be felt by the user.

[0078] While the preferred embodiment of the present invention has been described above, this is merely one embodiment that embodies the technical idea of the present invention, and any modifications or alterations that embody the technical idea of the present invention should be construed as falling within the scope of the present invention.

Claims

1. A composition for enhancing exfoliation, comprising serine as an exfoliant, A composition comprising a polyol humectant in an amount of more than 0 to 2% by weight.

2. The composition according to claim 1 , except that the exfoliant contains one or more active ingredients selected from tropolone and its derivatives.

3. The composition of claim 1 , wherein the composition is a cosmetic composition.

4. 2. The composition according to claim 1, wherein the composition comprises a polyol humectant in an amount of more than 0 to 0.5% by weight.

5. 2. The composition according to claim 1, wherein the polyol moisturizer is at least one selected from the group consisting of glycerin, dipropylene glycol, butylene glycol, glycereth-26, methyl gluceth-20, and pentylene glycol.

6. 2. The composition according to claim 1, wherein the exfoliant is contained in an amount of 0.001 to 20% by weight based on the total weight of the composition.

7. The composition described in claim 1, characterized in that the cosmetic composition has a pH of 5 to 8.

8. A product comprising the composition of any one of claims 1 to 7.

9. A method for enhancing exfoliation, comprising applying to skin a cosmetic composition comprising serine as an exfoliant, The cosmetic composition comprises a polyol moisturizer in an amount of more than 0 and not more than 2% by weight.

10. The method according to claim 9 , except that the exfoliant contains one or more active ingredients selected from tropolone and its derivatives.

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