Cosmetic compositions containing a large amount of ceramide-NPs

Abstract

The present disclosure relates to a stable cosmetic composition containing a large amount of ceramide NPs.The cosmetic composition further comprises a large amount of hydroxypropyltetrahydropyrantriol, a plurality of emulsifiers, fatty alcohols, fatty compounds, and water.A method for stabilizing the cosmetic composition containing a large amount of ceramide NPs and a method for treating skin with the cosmetic composition are also described.

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Patent Application No. 63 / 273,962, filed October 31, 2021, and French Patent Application Publication No. 2200818, filed January 31, 2022, which are incorporated herein by reference in their entireties.

[0002] The present disclosure relates to stable cosmetic compositions comprising a large amount of ceramide-NPs and methods for stabilizing cosmetic compositions containing a large amount of ceramide-NPs. The present disclosure also describes methods for treating skin with the cosmetic compositions. Summary of the Invention

[0003] In one aspect, the present disclosure relates to a cosmetic composition comprising, inter alia, a surprisingly high amount of ceramide-NPs. Furthermore, the composition also comprises a surprisingly high amount of hydroxypropyltetrahydropyrantriol. These active ingredients provide numerous cosmetic benefits to the skin, but historically, they have been extremely difficult to solubilize and stabilize, especially in large amounts. The inventors of the present disclosure have developed a surprisingly stable composition comprising, inter alia, a high amount of ceramide-NPs and a surprisingly high amount of hydroxypropyltetrahydropyrantriol. Due to the high amount of ceramide-NPs, the cosmetic composition provides excellent cosmetic properties to the skin, such as maintaining skin hydration and moisture balance, and alleviating / reducing itching, chronic dryness, peeling, and scaling. Ceramide-NPs also help strengthen the skin's natural lipid barrier, which is useful for treating dry and aging skin. Due to the high amount of hydroxypropyltetrahydropyrantriol, the cosmetic composition provides benefits such as reduction of fine lines and wrinkles, improved production of hyaluronic acid through stimulation of glycosaminoglycan (GAG) synthesis, and softening of the stratum corneum to reduce cumulative stress on the epidermis and dermis.

[0004] In one aspect, the present disclosure relates, inter alia, to a cosmetic composition in the form of an oil-in-water emulsion. In one embodiment, the cosmetic composition comprises: (a) Ceramide NP, (b) water; (c) one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) one or more second emulsifiers selected from glyceryl esters having an HLB (hydrophilic-lipophilic balance) of about 3 to about 6; (e) one or more third emulsifiers selected from ethoxylated fatty acids; (f) one or more fatty alcohols, and (g) one or more non-triglyceride and non-aromatic fatty compounds Including, The compositions are oil-in-water emulsions and all weight percentages are based on the total weight of the composition.

[0005] In certain embodiments, the cosmetic composition comprises one or more of the following weight ratios with respect to (a) and (c)-(g): a weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs of from about 1.5:1 to about 8:1 ((c):(a)); and / or a weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP of about 0.8:1 to about 4:1 ((d):(a)); and / or a weight ratio of one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NPs of about 0.7:1 to about 4:1 ((e):(a)); and / or a weight ratio of one or more fatty alcohols to ceramide NPs of about 0.7:1 to about 4:1 ((f):(a)); and / or A weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NPs of about 4:1 to about 20:1 ((g):(a)).

[0006] Non-limiting examples of polyglycerol emulsifiers include polyglyceryl 10-stearate, polyglyceryl-3-caprate, polyglyceryl-3-diisostearate, polyglyceryl-3 methylglucose distearate, or mixtures thereof.

[0007] Non-limiting examples of glyceryl esters having an HLB of about 3 to about 8 include glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl palmitate lactate, glyceryl stearate, glyceryl distearate, glyceryl laurate, or mixtures thereof. In at least one example, the glyceryl ester comprises glyceryl stearate, glyceryl ricinoleate, and mixtures thereof.

[0008] Non-limiting examples of ethoxylated fatty acids having 40-100 propylene oxide groups and fatty acid chains ranging from 12 to 24 carbons include lauric acid, tridecylic acid, myristic acid, pentadecylic acid, palmitic acid, margaric acid, stearic acid, nonadecylic acid, arachidic acid, henicosylic acid, behenic acid, tricosylic acid, and lignoceric acid, especially those containing 40-100 propylene oxide groups.

[0009] Non-limiting examples of fatty alcohols include those having 12 to 24 carbon atoms, such as fatty alcohols selected from cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, myristic or myristyl alcohol, arachidyl alcohol, lignoceryl alcohol, and mixtures thereof.

[0010] Non-limiting examples of non-triglyceride and non-aromatic fatty compounds include fatty esters (isopropyl myristate, sorbitan isostearate), sarcosinates such as acyl sarcosinates, vegetable oils and / or vegetable oils, and mixtures thereof. Non-limiting examples of sarcosinates include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, sodium caproyl sarcosinate, TEA-cocoyl sarcosinate, ammonium cocoyl sarcosinate, ammonium lauroyl sarcosinate, dimer dilinoleyl bis-lauroyl glutamate / lauroyl sarcosinate, disodium lauroamphodiacetate lauroyl sarcosinate, isopropyl lauroyl sarcosinate, sodium ... cocosinate, potassium cocoyl sarcosinate, potassium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium oleoyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TEA-oleoyl sarcosinate, TEA-palm kernel sarcosinate, and combinations thereof.

[0011] In various embodiments, the cosmetic composition may optionally include one or more thickening polymers. Non-limiting examples of various types of thickening polymers include polyacrylates, polymethacrylates, polyethyl acrylates, and polyacrylamides, acrylic acid / acrylonitrile copolymers, acrylates / steareth-20 itaconate copolymers, acrylates / ceteth-20 itaconate copolymers, acrylates / aminoacrylates / C10-30 alkyl PEG-20 itaconate copolymers, acrylates / aminoacrylate copolymers, acrylates / steareth-20 methacrylate copolymers, acrylates / beheneth-25 methacrylate copolymers, acrylates / steareth-20 methacrylate crosspolymers, acrylates / beheneth-25 methacrylate / HEMA crosspolymers, acrylates / vinyl neodecanoate crosspolymers, acrylates / vinyl isodecanoate crosspolymers, acrylates / palmeth-25 acrylate copolymers, acrylic acid / acrylamidomethylpropanesulfonic acid copolymers, and acrylates / C10-C 30 alkyl acrylate crosspolymer, carbomer, hydrophobically modified polypolyacrylate; hydrophobically modified polyacrylic acid, hydrophobically modified polyacrylamide; hydrophobically modified polyethers, where these materials may have a hydrophobicity selected from cetyl, stearyl, oleayl, and combinations thereof, acrylamide / ammonium acrylate copolymer; acrylamide / sodium acryloyldimethyl taurate copolymer / isohexadecane / polysorbate 80, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, acrylate copolymer, acrylate crosspolymer-4, acrylate crosspolymer-3, acrylates / beheneth-25 methacrylate copolymer, acrylates / C10-C30 alkyl acrylate crosspolymer, acrylates / steareth-20 itaconate copolymer, ammonium polyacrylate / isohexadecane / PEG-40 castor oil;Sodium carbomer, cross-linked polyvinylpyrrolidone (PVP), polyacrylamide / C13-14 isoparaffin / laureth-7, polyacrylate 13 / polyisobutene / polysorbate 20, polyacrylate crosspolymer-6, polyamide-3, polyquaternium-37, acrylamide / sodium acryloyldimethyltaurate / acrylic acid copolymer, sodium acrylate / acryloyldimethyltaurate, sodium polyacrylate, and mixtures thereof;

[0012] In various embodiments, the cosmetic composition may optionally include one or more water-soluble solvents. Non-limiting examples of water-soluble solvents include, for example, glycerin, alcohol (e.g., C 1-30 , C 1-15 , C 1-10 , or C 1-4 alcohols), organic solvents, polyols, glycols, and mixtures thereof.

[0013] In various embodiments, silicone can be optionally included in cosmetic composition, but preferably, composition does not contain or essentially does not contain silicone.Silicone is a synthetic polymer that is composed of repeating units of siloxane, elemental silicon and oxygen, combined with other elements, mostly carbon and hydrogen.Therefore, silicone is also called polysiloxane.In some examples, the cosmetic composition of this example can not contain or essentially does not contain dimethicone, amodimethicone, dimethiconol, cyclic siloxane, siloxane, etc.

[0014] In one embodiment, the cosmetic composition forms part of a kit that includes the cosmetic composition according to the present disclosure and one or more separately contained compositions. In one embodiment, the composition is contained in a kit that is a device, for example, a device that dispenses the cosmetic composition. In one embodiment, the device mixes the cosmetic composition with one or more additional cosmetic compositions before dispensing the mixture. Although a large amount of ceramide-NPs is included in the cosmetic composition, the composition is unique in that it is compatible with other cosmetic compositions, particularly other cosmetic compositions for treating skin.

[0015] Another aspect of the present disclosure relates to methods for stabilizing cosmetic compositions having a high amount of ceramide-NPs. As described throughout this disclosure, these methods include combining the ingredients to prepare the compositions of the present disclosure.

[0016] Another aspect of the present disclosure relates to a method for treating skin, which comprises applying a cosmetic composition according to the present disclosure to the skin. In one embodiment, the method hydrates the skin and / or maintains moisture balance, relieves / reduces itching, chronic dryness, peeling, and scaling, and improves the skin's natural lipid barrier, which is useful for treating dry and aging skin. In certain embodiments, when the composition contains hydroxypropyltetrahydropyrantriol, the method also reduces the appearance of fine lines and wrinkles, improves hyaluronic acid production through stimulation of glycosaminoglycan (GAG) synthesis, and softens the stratum corneum, reducing cumulative stress on the epidermis and dermis.

[0017] Other features and iterations of the present invention are described in more detail below. DETAILED DESCRIPTION OF THE INVENTION

[0018] A common problem associated with formulating compositions, especially compositions containing multiple ingredients, is ensuring physical stability, chemical stability, solubility, etc. Many additives incorporated into food, cosmetics, personal care, and household products are difficult to stabilize and solubilize, especially when used in large amounts. The consequences of stability and solubility problems can be significant. For example, stability problems can partially, if not completely, cause loss of product integrity, color loss, bad odor, viscosity changes, etc. Stability problems can also cause an increase or decrease in the amount of the target ingredient applied. With regard to active ingredients, stability problems can reduce or eliminate activity and prevent the active ingredients from reaching their intended target in the desired amount.

[0019] With aging, the outer layer of the skin (epidermis) thins, even though the number of cell layers remains unchanged. However, the number of pigment-containing cells (melanocytes) decreases. This causes the skin to appear thin and translucent. Large pigmented spots (senile lentigo, melasma, or lentigines) may appear in areas exposed to the sun. Changes in connective tissue reduce the strength and elasticity of the skin. This is known as elastosis. This is more noticeable in areas exposed to the sun (solar elastosis). Elastosis causes a leathery, weathered appearance common in farmers, sailors, and other people who spend a lot of time outdoors. Dehydration increases the risk of skin damage. Nutritional deficiencies can also adversely affect the skin, causing dryness, rashes, and swelling.

[0020] Human skin acts as the primary barrier between the body and its environment. Critical to this skin barrier function is the lipid matrix of the skin's outermost layer (epidermis), the stratum corneum (SC). Its two functions are (1) to prevent excessive water loss through the epidermis and (2) to prevent compounds from the environment from penetrating the viable epidermal and dermal layers and thereby triggering an immune response. The composition of the SC lipid matrix is ​​dominated by three lipid classes: cholesterol, free fatty acids, and ceramides. These lipids adopt a highly ordered three-dimensional structure of stacked, tightly packed lipid layers (lipid lamellae): lateral and lamellar lipid organization. The way in which these lipids are ordered depends on the lipid composition. One very common skin disease in which the SC lipid barrier is affected is atopic dermatitis (AD).

[0021] Specifically, what is needed is a composition containing high amounts of ceramide NPs that replenish ceramides in the lipid matrix of the outermost layer of skin, reducing the effects of aging and improving skin radiance, smoothness, etc.

[0022] In one aspect, the present disclosure relates to, inter alia, stable cosmetic compositions comprising a high amount of ceramide NPs and methods for stabilizing cosmetic compositions containing a high amount of ceramide NPs. In one embodiment, the composition comprises: (a) Ceramide NP, (b) water; (c) one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) one or more second emulsifiers selected from glyceryl esters having an HLB (hydrophilic-lipophilic balance) of about 3 to about 6; (e) one or more third emulsifiers selected from ethoxylated fatty acids; (f) one or more fatty alcohols, and (g) one or more non-triglyceride and non-aromatic fatty compounds Including, The composition is an oil-in-water emulsion, and the composition comprises one or more of the following weight ratios: a weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs of about 1.5:1 to about 8:1 ((c):(a)); and / or a weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP of about 0.8:1 to about 4:1 ((d):(a)); and / or a weight ratio of one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NPs of about 0.7:1 to about 4:1 ((e):(a)); and / or a weight ratio of one or more fatty alcohols to ceramide NPs of about 0.7:1 to about 4:1 ((f):(a)); A weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NPs of about 4:1 to about 20:1 ((g):(a)).

[0023] The composition may further comprise other ingredients, such as (i) one or more thickening polymers, and / or (j) one or more water-soluble solvents, and / or (k) one or more miscellaneous ingredients, as described throughout this disclosure. In certain embodiments, the composition may optionally comprise one or more silicones, although preferably the composition is free or essentially free of silicones.

[0024] In one aspect, the present disclosure relates to, inter alia, stable cosmetic compositions comprising a high amount of ceramide NPs and methods for stabilizing cosmetic compositions containing a high amount of ceramide NPs. In one embodiment, the composition comprises: (a) about 0.1 to about 5 wt. % of ceramide NPs; (b) water; (c) about 0.5 to about 5 wt. % of one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) about 0.5 to about 5% by weight of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6; (e) about 0.5 to about 5 wt. % of one or more third emulsifiers selected from ethoxylated fatty acids; (f) about 0.2 to about 5% by weight of one or more fatty alcohols, and (g) about 4 to about 20% by weight of one or more non-triglyceride and non-aromatic fatty compounds Including, The compositions are oil-in-water emulsions and all weight percentages are based on the total weight of the composition.

[0025] The composition may further comprise other ingredients, such as (i) one or more thickening polymers, and / or (j) one or more water-soluble solvents, and / or (k) one or more miscellaneous ingredients, as described throughout this disclosure. In certain embodiments, the composition may optionally comprise one or more silicones, although preferably the composition is free or essentially free of silicones.

[0026] In one aspect, the present disclosure relates to, inter alia, stable cosmetic compositions comprising a high amount of ceramide NPs and methods for stabilizing cosmetic compositions containing a high amount of ceramide NPs. In one embodiment, the composition comprises: (a) about 0.1 to about 5 wt. % of ceramide NPs; (b) water; (c) about 0.5 to about 5 wt. % of one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) about 0.5 to about 5% by weight of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6; (e) about 0.5 to about 5 wt. % of one or more third emulsifiers selected from ethoxylated fatty acids; (f) about 0.2 to about 5% by weight of one or more fatty alcohols, and (g) about 4 to about 20% by weight of one or more non-triglyceride and non-aromatic fatty compounds Including, The composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the composition, provided that one or more of the following ratios apply: a weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs of about 1.5:1 to about 8:1 ((c):(a)); and / or a weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP of about 0.8:1 to about 4:1 ((d):(a)); and / or a weight ratio of one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NPs of about 0.7:1 to about 4:1 ((e):(a)); and / or a weight ratio of one or more fatty alcohols to ceramide NPs of about 0.7:1 to about 4:1 ((f):(a)); A weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NPs of about 4:1 to about 20:1 ((g):(a)).

[0027] (a) Ceramide NP Ceramide NP stands for "(9Z)-N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]octadec-9-enamide." Ceramide NP consists of a phytosphingosine skeleton N-acylated with saturated fatty acid (stearic acid). Ceramide NP provides many benefits to the skin, including hydrating dry skin, reducing itching and chronic dryness, alleviating itching, and reducing peeling and scaling.

[0028] Generally, the amount of ceramide NP in the cosmetic composition ranges from about 0.1% to about 5% by weight, based on the total weight of the composition. In various embodiments, the amount of ceramide NPs ranges from about 0.1 wt % to about 4.0 wt %, about 0.1 to about 3 wt %, about 0.2 wt % to about 5 wt %, about 0.2 to about 4 wt %, about 0.2 to about 2 wt %, about 0.2 to about 3 wt %, about 0.3 to about 5 wt %, about 0.3 to about 4 wt %, about 0.3 to about 3 wt %, about 0.3 to about 2 wt %, about 0.4 to about 5 wt %, about 0.4 to about 4 wt %, about 0.4 to about 3 wt %, about 0.4 to about 2 wt %, about 0.5 wt % to about 5 wt %, about 0.5 wt %, about 4 wt %, about 0.5 wt % to about 3 wt %, about 0.5 to about 2 wt %, or 0.5 to about 1 wt %, based on the total weight of the composition. In still further embodiments, the amount of ceramide NPs is at least 0.1 wt.%, at least 0.2 wt.%, at least 0.3 wt.%, at least 0.4 wt.%, at least 0.5 wt.%, or at least 0.6 wt.%, and may have up to about 1, 2, 3, 4, or 5 wt.%, relative to the total weight of the composition.

[0029] (b) water The amount of water in the compositions of the present disclosure can and will vary depending on the amounts of other ingredients in the cosmetic composition. Nevertheless, in certain embodiments, the amount of water in the composition is about 50 to about 90 wt. %, based on the total weight of the composition. In various embodiments, the amount of water in the cosmetic composition is about 55 to about 90 wt. %, about 60 to about 90 wt. %, about 65 to about 90 wt. %, about 70 to about 90 wt. %, about 60 to about 85 wt. %, about 65 to about 85 wt. %, about 70 to about 85 wt. %, about 60 to about 80 wt. %, about 65 to about 80 wt. %, or about 70 to about 80 wt. %, based on the total weight of the composition.

[0030] (c) Polyglycerol-based emulsifier The cosmetic composition of the present disclosure comprises one or more first emulsifiers selected from polyglycerol-based emulsifiers.Non-limiting examples include polyglyceryl 10-stearate, polyglyceryl-3-caprate, polyglyceryl-3-diisostearate, polyglyceryl-3 methylglucose distearate, or mixtures thereof.In various embodiments, the polyglycerol-based emulsifier is represented by the following formula: It may also be a polyglycerol ester of a fatty acid having a structure according to TIFF0007728457000001.tif14170.

[0031] In the formula, n is 2 to 20, 2 to 10, or 2 to 5, or 2, 3, 4, 5, 6, 7, 8, 9, or 10; R 1 , R 2 and R 3 may each independently be a fatty acid moiety or hydrogen, with the proviso that R 1 , R 2 , and R 3 At least one of R is a fatty acid moiety. 1 , R 2 and R 3 may be saturated or unsaturated, straight chain or branched, C1-C 40 , C1-C 30 , C1-C 25 , or C1-C 20 , C1-C 16、 or C1-C 10 Additionally, non-limiting examples of nonionic polyglycerol esters of fatty acids include polyglyceryl-4 caprylate / caprate, polyglyceryl-10 caprylate / caprate, polyglyceryl-4 caprate, polyglyceryl-10 caprate, polyglyceryl-4 laurate, polyglyceryl-5 laurate, polyglyceryl-6 laurate, polyglyceryl-10 laurate, polyglyceryl-10 cocoate, polyglyceryl-10 myristate, polyglyceryl-10 oleate, polyglyceryl-10 stearate, and mixtures thereof.

[0032] In certain embodiments, the polyglycerol-based emulsifier may be selected from polyglyceryl esters of C12-22 saturated, unsaturated, and branched-chain fatty acids, such as polyglyceryl-4 isostearate, polyglyceryl-3 oleate, polyglyceryl-2-sesquioleate, triglyceryl diisostearate, diglyceryl monooleate, tetraglyceryl monooleate, and mixtures thereof. Non-limiting examples of glyceryl esters may include glyceryl caprylate, glyceryl caprate, glyceryl cocoate, glyceryl laurate, and combinations thereof.

[0033] In some embodiments, particularly useful polyglycerol-based emulsifiers include polyglyceryl methyl glucose surfactants, such as polyglyceryl-3 methyl glucose distearate, polyglyceryl-6 methyl glucose distearate, polyglyceryl-10 methyl glucose distearate, and mixtures thereof.

[0034] The amount of one or more first emulsifiers selected from polyglycerol-based emulsifiers varies, but in some embodiments is about 0.5% to about 5% by weight based on the total weight of the composition. In various embodiments, the amount of one or more first emulsifiers selected from polyglycerol-based emulsifiers is about 0.5% to about 4%, about 0.5 to about 3%, about 0.5 to about 2%, about 0.6 to about 5%, about 0.6 to about 4%, about 0.6 to about 3%, about 0.6 to about 2%, about 0.8 to about 4%, about 0.8 to about 3%, or about 0.8 to about 2% by weight based on the total weight of the composition.

[0035] (d) glyceryl esters having an HLB of about 3 to about 6 The compositions of the present disclosure include one or more secondary emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6. These are different from the polyglycerol-based emulsifiers described above. Suitable, non-limiting examples of glyceryl esters having an HLB of about 3 to about 6 are selected from glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl stearate, glyceryl dioleate, glyceryl distearate, or mixtures thereof. In at least one example, the glyceryl ester includes glyceryl stearate, glyceryl ricinoleate, or mixtures thereof.

[0036] In some examples, the glyceryl ester may be selected from oligomeric glycerol, arachidyl propionate, phytosterol esters, esters of triglycerides of fatty acids and their derivatives, non-crosslinked polyesters resulting from the polycondensation of linear or branched C4-C50 dicarboxylic or polycarboxylic acids with C2-C50 diols or polyols, aliphatic esters of esters resulting from the esterification of aliphatic hydroxycarboxylic esters with aliphatic carboxylic acids, and mixtures thereof. Non-limiting examples of glyceryl esters include glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl stearate, glyceryl stearate citrate, glyceryl distearate, glyceryl laurate, or mixtures thereof. In at least one example, the glyceryl ester comprises glyceryl stearate, bis-diglyceryl polyacyladipate, or a mixture thereof. In at least one other example, the glyceryl ester comprises glyceryl stearate.

[0037] Generally, the amount of one or more secondary emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 may range from about 0.5% to about 5% by weight, based on the total weight of the composition. In various embodiments, the amount of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 may be in the range of about 0.2 to about 5 wt.%, about 0.2 to about 4 wt.%, about 0.2 to about 3 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.6 to about 5 wt.%, about 0.6 to about 4 wt.%, about 0.6 to about 3 wt.%, about 0.6 to about 2 wt.%, about 0.8 to about 4 wt.%, about 0.8 to about 3 wt.%, or about 0.8 to about 2 wt.%, about 1.0 to about 4 wt.%, about 1.0 to about 3 wt.%, or about 1.0 to about 2 wt.%, based on the total weight of the composition.

[0038] (e) Ethoxylated fatty acids The composition of the present disclosure includes one or more third emulsifiers selected from ethoxylated fatty acids. "Ethoxylated fatty acids" are also known as "ethoxylated fatty acid esters" and "polyethoxylated fatty acids." These are formed when fatty acids react with alkylene oxides. The resulting product may be a monoester, a diester, or a mixture thereof.

[0039] Ethoxylated fatty acids have the formula RC(O)O(CH2CH2O) n-H, where R represents an aliphatic residue of a fatty acid, and n represents the number of ethylene oxide molecules. In another embodiment, n is an integer ranging from 2 to 200, 2 to 150, 2 to 100, 2 to 50, 3 to 200, 3 to 150, 3 to 100, 3 to 50, or 3 to 25, and in a further embodiment, from 3 to 10. In yet another embodiment of the present invention, R is derived from a fatty acid containing 8 to 24 carbon atoms. Exemplary ethoxylated fatty acids include, but are not limited to, capric acid ethoxylate, lauric acid ethoxylate, myristic acid ethoxylate, stearic acid ethoxylate, oleic acid ethoxylate, coconut fatty acid ethoxylate, and polyethylene glycol 400 propoxylated monolaurate, wherein the number of ethylene oxide units in each of the foregoing ethoxylates can range from 2 or more in one embodiment, and from 2 to about 200, 2 to 200, 2 to 150, 2 to 100, 2 to 50, 3 to 200, 3 to 150, 3 to 100, 3 to 50, or 3 to 25 in another embodiment. More specific examples of ethoxylated fatty acids are PEG-8 distearate (8 refers to the number of repeating ethylene oxide units), PEG-8 behenate, PEG-8 caprate, PEG-8 caprylate, PEG-8 caprylate / caprate, PEG cocoate (PEG without a number designation refers to the number of ethylene oxide units ranging from 2 to 50), PEG-15 dicoate, PEG-2 diisononanoate, PEG-8 diisostearate, PEG-dilaurate, PEG-dioleate PEG-distearate, PEG ditallate, PEG-isostearate, PEG-jojoba acid, PEG-laurate, PEG-linolenate, PEG-myristate, PEG-oleate, PEG-palmitate, PEG-ricinoleate, PEG-stearate, PEG-tholate, and the like.

[0040] Examples of ethoxylated fatty acids that may be mentioned include adducts of ethylene oxide with esters of lauric acid, palmitic acid, stearic acid or behenic acid, and mixtures thereof, in particular those containing 9 to 100 oxyethylene groups, such as PEG-9 to PEG-50 laurate (CTFA names: PEG-9 laurate to PEG-50 laurate); PEG-9 to PEG-50 palmitate (CTFA names: PEG-9 palmitate to PEG-50 palmitate); PEG-9 to PEG-50 stearate (CTFA names: PEG-9 stearate to PEG-50 stearate); PEG-9 to PEG-50 palmitostearate; PEG-9 to PEG-50 behenate (CTFA names: PEG-9 behenate to PEG-50 behenate); polyethylene glycol 100 EO monostearate (CTFA name: PEG-100 stearate); and mixtures thereof.

[0041] In some examples, the one or more ethoxylated fatty acids are selected from polyethoxylated stearates, such as PEG-9 stearate, PEG-8 distearate, PEG-20 stearate, PEG-8 stearate, PEG-8 oleate, PEG-20 stearate, PEG-30 stearate, PEG-40 stearate, PEG-50 stearate, PEG-100 stearate, PEG-150 laurate, and combinations thereof.

[0042] The amount of one or more tertiary emulsifiers selected from ethoxylated fatty acids varies. Nevertheless, in various embodiments, it is about 0.5% to about 5% by weight based on the total weight of the composition. In various embodiments, the total amount of one or more tertiary emulsifiers selected from ethoxylated fatty acids is about 0.2 to about 5%, about 0.2 to about 4%, about 0.2 to about 3%, about 0.5 to about 4%, about 0.5 to about 3%, about 0.5 to about 2%, about 0.6 to about 5%, about 0.6 to about 4%, about 0.6 to about 3%, about 0.6 to about 2%, about 0.8 to about 4%, about 0.8 to about 3%, or about 0.8 to about 2%, about 1.0 to about 4%, about 1.0 to about 3%, or about 1.0 to about 2% by weight based on the total weight of the composition.

[0043] (f) fatty alcohols The term "fatty alcohol" refers to an alcohol containing at least one hydroxyl group (OH), at least 8 carbon atoms, that is not oxyalkylenated (in particular not oxyethylenated or oxypropylenated), and that is not glycerolated. Fatty alcohols can be represented by R-OH, where R represents a linear or branched, saturated (alkyl) or unsaturated (alkenyl) group containing 8 to 40 carbon atoms, preferably 10 to 30 carbon atoms, more preferably 12 to 24 carbon atoms, and even more preferably 14 to 22 carbon atoms.

[0044] Fatty alcohol can be liquid or solid.In some examples, cosmetic composition preferably comprises at least one solid fatty alcohol.The solid fatty alcohol that can be used includes those that are solid at room temperature and atmospheric pressure (25 ℃, 780 mmHg) and are insoluble in water, that is, those that have a water solubility of less than 1 wt%, preferably less than 0.5 wt%, at 25 ℃, 1 atm.

[0045] The solid fatty alcohol may be represented by R-OH, where R represents a linear alkyl group optionally substituted with one or more hydroxyl groups, containing 8 to 40 carbon atoms, preferably 10 to 30 carbon atoms, more preferably 12 to 24 carbon atoms, and even more preferably 14 to 22 carbon atoms.

[0046] Non-limiting examples of useful fatty alcohols include lauryl alcohol or lauryl alcohol (1-dodecanol); myristic or myristyl alcohol (1-tetradecanol); cetyl alcohol (1-hexadecanol); stearyl alcohol (1-octadecanol); arachidyl alcohol (1-eicosanol); behenyl alcohol (1-docosanol); lignoceryl alcohol (1-tetracosanol); seryl alcohol (1-hexacosanol); montanyl alcohol (1-octacosanol); myricylic alcohol (1-triacontanol), and mixtures thereof.

[0047] In certain embodiments, the one or more fatty alcohols have 12 to 24 carbon atoms. Specific non-limiting examples include cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, myristic or myristyl alcohol, arachidyl alcohol, lignoceryl alcohol, or mixtures thereof.

[0048] Preferably, the cosmetic composition comprises one or more solid fatty alcohols selected from, for example, cetyl alcohol, stearyl alcohol, behenyl alcohol and mixtures thereof, such as cetylstearyl or cetearyl alcohol.

[0049] Liquid fatty alcohols, especially those containing C10-C34, preferably have a branched carbon chain and / or have one or more, preferably 1 to 3, double bonds. They are preferably branched and / or unsaturated (C=C double bonds) and contain 12 to 40 carbon atoms.

[0050] The liquid fatty alcohol may be represented by R-OH, where R represents a C12-C24 branched alkyl or alkenyl group (containing at least one C12-C24 double bond C=C), and R may be substituted with one or more hydroxy groups. Preferably, the liquid fatty alcohol is a branched saturated alcohol. Preferably, R does not contain a hydroxyl group. These include oleic alcohol, linoleic alcohol, linolenic alcohol, isocetyl alcohol, isostearyl alcohol, 2-octyl-1-dodecanol, 2-butyloctanol, 2-hexyl-1-decanol, 2-decyl-1-tetradecanol, 2-tetradecyl-1-cetanol, and mixtures thereof. Preferably, the liquid fatty alcohol is 2-octyl-1-dodecanol.

[0051] In some examples, the cosmetic composition comprises one or more fatty alcohols selected from decyl alcohol, undecyl alcohol, dodecyl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, isostearyl alcohol, isocetyl alcohol, behenyl alcohol, linalool, oleyl alcohol, myricyl alcohol, and mixtures thereof. In some examples, the cosmetic composition preferably comprises stearyl alcohol.

[0052] The amount of one or more fatty alcohols in the cosmetic composition may vary, but in various embodiments, ranges from about 0.2% to about 5% by weight, based on the total weight of the composition. In various embodiments, the amount of one or more fatty alcohols in the composition ranges from about 0.2% to about 5%, from about 0.2% to about 4%, from about 0.2% to about 3%, from about 0.2% to about 2%, from about 0.3% to about 5%, from about 0.3% to about 4%, from about 0.3% to about 3%, from about 0.3% to about 2%, from about 0.5% to about 4%, from about 0.5% to about 3%, from about 0.5% to about 2%, from about 0.7% to about 4%, from about 0.7% to about 3%, or from about 0.7% to about 2% by weight, based on the total weight of the composition.

[0053] (g) Non-triglyceride and non-aromatic fatty compounds The cosmetic compositions of the present disclosure include one or more non-triglyceride and non-aromatic fatty compounds. Non-triglyceride and non-aromatic fatty compounds are distinct from ethoxylated fatty acids (e) and fatty alcohols (f). Furthermore, as the names suggest, they are not triglycerides or aromatic fatty compounds. The term "fatty compound" is interchangeable with "fatty material." Fatty compounds are known as compounds that are not soluble (or only slightly soluble) in water. They are hydrophilic and often solubilized in organic solvents. They include materials such as oils, fats, waxes, hydrocarbons, and fatty esters. For purposes of this disclosure, "fatty compound" does not include glycerides, aromatic fatty compounds, ethoxylated fatty acids, and fatty alcohols, as described above. Furthermore, silicones are not considered fatty compounds according to the present disclosure. In certain embodiments, non-limiting examples of non-triglyceride and non-aromatic fatty compounds include oils, waxes, alkanes (paraffins), fatty acids, fatty esters, lanolin, hydrocarbons, derivatives thereof, and mixtures thereof. Fatty compounds are described by the International Federation Societies of Cosmetic Chemists, for example, in Cosmetic Raw Material Analysis and Quality, Volume I: Hydrocarbons, Glycerides, Waxes and Other Esters (Redwood Books, 1994), which is incorporated herein by reference in its entirety.

[0054] Non-limiting examples of non-triglyceride and non-aromatic fatty compounds include fatty esters (isopropyl myristate, sorbitan isostearate), sarcosinates such as acyl sarcosinates, vegetable oils and / or vegetable oils, and mixtures thereof. Non-limiting examples of sarcosinates include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, sodium caproyl sarcosinate, TEA-cocoyl sarcosinate, ammonium cocoyl sarcosinate, ammonium lauroyl sarcosinate, dimer dilinoleyl bis-lauroyl glutamate / lauroyl sarcosinate, disodium lauroamphodiacetate lauroyl sarcosinate, isopropyl lauro ... Examples of suitable sarcosinates include potassium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium oleoyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TEA-oleoyl sarcosinate, TEA-palm kernel sarcosinate, and combinations thereof.

[0055] In one embodiment, the one or more non-triglyceride and non-aromatic fatty compounds are preferably selected from fatty esters (e.g., isopropyl myristate, sorbitan isostearate), acyl sarcosinates (e.g., isopropyl lauroyl sarcosinate), and mixtures thereof.

[0056] Non-limiting examples of non-triglyceride and non-aromatic fatty compounds include oils, mineral oils, alkanes (paraffins), fatty acids, fatty alcohol derivatives, fatty acid derivatives, esters of fatty alcohols, hydroxy-substituted fatty acids, waxes, lanolin, and mixtures thereof.

[0057] Fatty alcohol derivatives Fatty alcohol derivatives include fatty esters derived from one or more fatty alcohols. Fatty alcohol derivatives also include, for example, alkoxylated fatty alcohols having from about 1 to about 100 moles of alkylene oxide per mole of alkoxylated fatty alcohol. For example, the alkoxylated fatty alcohol may be alkoxylated with from about 1 to about 80 moles, from about 2 to about 50 moles, from about 5 to about 45 moles, from about 10 to about 40 moles, or from 15 to about 35 moles (more) of alkylene oxide per mole of alkoxylated fatty alcohol, including all ranges and subranges therebetween.

[0058] Examples of alkoxylated fatty alcohols include steareth (e.g., steareth-2, steareth-20, and steareth-21), laureth (e.g., laureth-4 and laureth-12), ceteth (e.g., ceteth-10 and ceteth-20), and ceteareth (e.g., ceteareth-2, ceteareth-10, and ceteareth-20). In at least one example, the one or more alkoxylated fatty alcohols include steareth-20. In some examples, the one or more alkoxylated fatty alcohols may be exclusively steareth-20.

[0059] Further fatty alcohol derivatives that may optionally be suitable include methyl stearyl ether; 2-ethylhexyldodecyl ether; stearyl acetate; cetyl propionate; ceteth series compounds such as ceteth-1 to ceteth-45, which are ethylene glycol ethers of cetyl alcohol (alcochol) (the number designation indicates the number of ethylene glycol moieties present); steareth series compounds such as steareth-1 to 10, which are ethylene glycol ethers of steareth alcohol (the number designation indicates the number of ethylene glycol moieties present); ceteareth-1 to ceteareth-10, which are ethylene glycol ethers of ceteareth alcohol, These include mixtures of fatty alcohols containing primarily cetyl and stearyl alcohol (the number designation indicates the number of ethylene glycol moieties present); C1-C30 alkyl ethers of the just-described ceteth, steareth, and ceteareth compounds; polyoxyethylene ethers of branched alcohols such as octyldodecyl alcohol, dodecylpentadecyl alcohol, hexyldecyl alcohol, and isostearyl alcohol; polyoxyethylene ethers of behenyl alcohol; PPG ethers such as PPG-9-steareth-3, PPG-11 stearyl ether, PPG8-ceteth-1, and PPG-10 cetyl ether; and mixtures thereof.

[0060] Fatty acids and fatty acid derivatives The fatty acids may be straight-chain or branched-chain acids and / or saturated or unsaturated. Non-limiting examples of fatty acids include diacids, triacids, and other multiple acids, as well as salts of these fatty acids. For example, the fatty acids may optionally include or be selected from lauric acid, palmitic acid, stearic acid, behenic acid, arachidonic acid, oleic acid, isostearic acid, sebacic acid, and mixtures thereof. In some cases, the fatty acid is selected from the group consisting of palmitic acid, stearic acid, and mixtures thereof.

[0061] The fatty acid derivative is not a polyglycerol ester of fatty acid (c), but may be, for example, a fatty acid ester of a fatty alcohol, a fatty acid ester of a fatty alcohol derivative, a fatty acid ester of an alcohol, a hydroxy-substituted fatty acid, or a mixture thereof.Non-limiting examples of the fatty acid derivative include ricinoleic acid, glycerol monostearate, 12-hydroxystearic acid, ethyl stearate, cetyl stearate, cetyl palmitate, polyoxyethylene cetyl ether stearate, polyoxyethylene stearyl ether stearate, polyoxyethylene lauryl ether stearate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol distearate, trimethylolpropane distearate, sorbitan stearate, dimethyl sebacate, PEG-15 cocoate, PPG-15 stearate, glyceryl monostearate, glyceryl distearate, glyceryl tristearate, or a mixture thereof.

[0062] wax Non-limiting examples of waxes in this category include, for example, synthetic waxes, ceresin, paraffin, ozokerite, polyethylene wax, illipe butter, beeswax, carnauba, microcrystalline, lanolin, lanolin derivatives, candelilla, cocoa butter, shellac wax, spermaceti, rice bran wax, capok wax, sugarcane wax, montan wax, whale wax, bayberry wax, acacia decurrents flower wax, vegetable waxes (e.g., sunflower seed (helianthus annuus), carnauba, candelilla, ouricury or Japan wax or cork fiber or sugarcane wax), or mixtures thereof.

[0063] oil Suitable oils include, but are not limited to, natural oils such as coconut oil; hydrocarbons such as mineral oil and hydrogenated polyisobutene; fatty alcohols such as octyldodecanol; 12-C 15 Esters such as alkyl benzoates, diesters such as propylene dipelarganate, and triesters such as glyceryl trioctanoate. Non-limiting examples of oils that may optionally be included in the cosmetic composition include isotridecyl isononanoate, PEG-4 diheptanoate, isostearyl neopentanoate, tridecyl neopentanoate, cetyl octanoate, cetyl palmitate, cetyl ricinoleate, cetyl stearate, cetyl myristate, coco-dicaprylate / caprate, decyl isostearate, isodecyl oleate, isodecyl neopentanoate, isohexyl neopentanoate, octyl palmitate, dioctyl malate, tridecyl octanoate, myristyl myristate, octododecanol or octyldodecanol, acetylated lanolin alcohol, cetyl acetate, isododecane, methyl methyl acrylate, methyl meth ... In some embodiments, the inactive ingredient may be selected from the group consisting of glyceryl stearate, glyceryl triacetylhydroxystearate, glyceryl triacetylricinoleate, glyceryl trioctanoate, hydrogenated castor oil, linseed oil, mink oil, olive oil, palm oil, illipe butter, rapeseed oil, soybean oil, sunflower seed oil, tallow, tricaprin, trihydroxystearin, triisostearin, trilaurin, trilinolein, trimyristin, triolein, tripalmitin, tristearin, walnut oil, wheat germ oil, cholesterol, or combinations thereof.

[0064] Acyl Sarcosinate Non-limiting examples of acyl sarcosinates include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium myristoyl sarcosinate, sodium caproyl sarcosinate, TEA-cocoyl sarcosinate, ammonium cocoyl sarcosinate, ammonium lauroyl sarcosinate, dimer dilinoleyl bis-lauroyl glutamate / lauroyl sarcosinate, disodium lauroamphodiacetate lauroyl sarcosinate, isopropyl lauroyl sarcosinate, potassium cocoyl sarcosinate, potassium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, sodium oleoyl sarcosinate, sodium palmitoyl sarcosinate, TEA-cocoyl sarcosinate, TEA-lauroyl sarcosinate, TEA-oleoyl sarcosinate, TEA-palm kernel sarcosinate, and combinations thereof.

[0065] In preferred embodiments, the one or more non-triglyceride and non-aromatic fatty compounds are selected from fatty esters (e.g., isopropyl myristate, sorbitan isostearate), acyl sarcosinates (e.g., isopropyl lauroyl sarcosinate), and mixtures thereof.

[0066] The total amount of the one or more non-triglyceride and non-aromatic fatty compounds may vary. Nevertheless, in certain embodiments, the total amount of the non-triglyceride and non-aromatic fatty compounds is about 4 to about 20 wt. % based on the total weight of the composition. In further embodiments, the total amount of the one or more non-triglyceride and non-aromatic fatty compounds is about 1 to about 20 wt. %, about 1 to about 15 wt. %, about 1 to about 10 wt. %, about 2 to about 20 wt. %, about 2 to about 15 wt. %, about 2 to about 10 wt. %, about 3 to about 20 wt. %, about 3 to about 15 wt. %, about 3 to about 10 wt. %, about 4 to about 20 wt. %, about 4 to about 15 wt. %, or about 4 to about 10 wt. % based on the total weight of the composition.

[0067] (h) Hydroxypropyltetrahydropyrantriol The cosmetic composition of the present disclosure does not necessarily require or contain hydroxypropyltetrapyrantriol - it is optional. Nevertheless, in various embodiments, it is preferable to include hydroxypropyltetrapyrantriol. Hydroxypropyltetrapyrantriol is a sugar-protein hybrid made from xylose, which can effectively activate the synthesis of GAG (glycosaminoglycan), promote the production of hyaluronic acid, collagen synthesis, adhesion between the dermis and epidermis, synthesis of epidermal structural components, regeneration of damaged tissue, and maintain skin elasticity.

[0068] The amount of hydroxypropyltetrapyrantriol, if present, in the composition will vary. Nevertheless, in various embodiments, the total amount of hydroxypropyltetrapyrantriol is about 10% to about 40% by weight, based on the total weight of the composition. In further embodiments, the total amount of hydroxypropyltetrapyrantriol in the composition is about 10% to about 35%, about 10 to about 30%, about 10 to about 25%, about 10 to about 20%, about 12 to about 35%, about 12 to about 30%, about 12 to about 25%, about 12 to about 20%, about 12 to about 18%, about 14 to about 30%, about 14 to about 25%, about 14 to about 20%, or about 14 to about 18% by weight, based on the total weight of the composition.

[0069] (i) Thickening polymer In various embodiments, the cosmetic compositions of the present disclosure may optionally include one or more thickening polymers. Non-limiting examples of various types of thickening polymers include polyacrylates, polymethacrylates, polyethyl acrylates, and polyacrylamides, acrylic acid / acrylonitrile copolymers, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymers, acrylates / steareth-20 itaconate copolymers, acrylates / ceteth-20 itaconate copolymers, acrylates / aminoacrylates / C10-30 alkyl PEG ... Acrylates / Steareth-20 Methacrylate Copolymer, Acrylates / Beheneth-25 Methacrylate Copolymer, Acrylates / Steareth-20 Methacrylate Crosspolymer, Acrylates / Beheneth-25 Methacrylate / HEMA Crosspolymer, Acrylates / Vinyl Neodecanoate Crosspolymer, Acrylates / Vinyl Isodecanoate Crosspolymer, Acrylates / Palmethicone-25 Acrylate Copolymer, Acrylic Acid / Acrylamidomethylpropanesulfonic Acid copolymer, and acrylates / C10-C30 alkyl acrylate crosspolymer, carbomer, hydrophobically modified polypolyacrylate; hydrophobically modified polyacrylic acid, hydrophobically modified polyacrylamide; hydrophobically modified polyethers, where these materials may have a hydrophobicity selected from cetyl, stearyl, oleayl, and combinations thereof, acrylamide / ammonium acrylate copolymer; acrylamide / sodium acryloyldimethyl taurate copolymer / isohexadecane / polysorbate 80, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, acrylate copolymer, acrylate crosspolymer-4, acrylate crosspolymer-3, acrylates / beheneth-25 methacrylate copolymer, acrylates / C10-C30 alkyl acrylate crosspolymer, acrylates / steareth-20 itaconate copolymer, ammonium polyacrylate / isohexadecane / PEG-40 castor oil;Sodium carbomer, cross-linked polyvinylpyrrolidone (PVP), polyacrylamide / C13-14 isoparaffin / laureth-7, polyacrylate 13 / polyisobutene / polysorbate 20, polyacrylate crosspolymer-6, polyamide-3, polyquaternium-37, acrylamide / sodium acryloyldimethyltaurate / acrylic acid copolymer, sodium acrylate / acryloyldimethyltaurate, sodium polyacrylate, and mixtures thereof;

[0070] Among the non-ionic thickening polymers that may be mentioned are:

[0071] (1) Cellulose modified with a group containing at least one fatty chain; examples that may be mentioned include hydroxyethyl cellulose modified with a group containing at least one fatty chain, such as an alkyl, arylalkyl or alkylaryl group, or a mixture thereof, the alkyl group preferably having a C8-C22 group, such as the product NATROSOL PLUS GRADE 330 CS (C 16 alkyl), or the product BERMOCOLL EHM 100 sold by Berol Nobel, and hydroxyethyl cellulose modified with alkylphenyl polyalkylene glycol ether groups, such as AMERCELL POLYMER HM-1500 (polyethylene glycol (15) nonylphenyl ether) sold by Amerchol; (2) Hydroxypropyl guar modified with a group containing at least one fatty chain, such as the product ESAFLOR HM 22 (C) sold by the company Lamberti. 22 alkyl chain), as well as the product RE210-18 (C 14 alkyl chain) and RE205-1(C 20 alkyl chain), (3) copolymers of vinylpyrrolidone with fatty-chain hydrophobic monomers; examples which may be mentioned include the products ANTARON V216 or GANEX V216 (vinylpyrrolidone / hexadecene copolymer) sold by the company ISP, ANTARON V220 or GANEX V220 (vinylpyrrolidone / eicosene copolymer) sold by the company ISP, (4) copolymers of C1-C6 alkyl methacrylates or acrylates with amphiphilic monomers containing at least one fatty chain, such as the oxyethylenated methyl acrylate / stearyl acrylate copolymer sold under the name ANTIL 208 by Goldschmidt; (5) Copolymers of hydrophilic methacrylates or acrylates with hydrophobic monomers containing at least one fatty chain, such as polyethylene glycol methacrylate / lauryl methacrylate copolymers; (6) Polyurethane polyethers containing in the chain both hydrophilic blocks, usually of polyoxyethylenated nature, and hydrophobic blocks which may be solely aliphatic and / or cycloaliphatic and / or aromatic sequences.

[0072] In particularly preferred embodiments, the one or more thickening polymers are selected from polyacrylates (e.g., sodium polyacrylate), hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, acrylamide / sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, polyacrylamide, acrylate c10-30 alkyl acrylate crosspolymer, and mixtures thereof.

[0073] The amount of one or more thickening polymers, if present, will vary. Nevertheless, in various embodiments, the total amount of one or more thickening polymers is from about 0.01 to about 5 wt. %, based on the total weight of the composition. In further embodiments, the total amount of one or more thickening polymers is from about 0.01 to about 4 wt. %, from about 0.01 to about 3 wt. %, from about 0.1 to about 5 wt. %, from about 0.1 to about 4 wt. %, from about 0.1 to about 3 wt. %, from about 0.5 to about 5 wt. %, from about 0.5 to about 4 wt. %, or from about 0.5 to about 3 wt. %, from about 1 to about 5 wt. %, from about 1 to about 4 wt. %, or from about 1 to about 3 wt. %, from about 1.5 to about 5 wt. %, from about 1.5 to about 4 wt. %, or from about 1.5 to about 3 wt. %, based on the total weight of the composition.

[0074] (j) Water-soluble solvent The term "water-soluble solvent" is interchangeable with the term "water-miscible solvent" and refers to a compound that is liquid at 25°C and atmospheric pressure (760 mmHg) and has at least 50% solubility in water under these conditions. In some cases, the water-soluble solvent has a solubility of at least 60%, 70%, 80%, or 90%. Non-limiting examples of water-soluble solvents include, for example, glycerin, alcohols (e.g., C 1-10 or C 1-4 alcohols), organic solvents, polyols, glycols, and mixtures thereof.

[0075] Examples of organic solvents include, but are not limited to, monoalcohols and polyols, such as ethyl alcohol, isopropyl alcohol, propyl alcohol, isopropyl alcohol, benzyl alcohol, 4-tert-butylcyclohexanol, and phenylethyl alcohol, or glycols or glycol ethers, such as the monomethyl, monoethyl, and monobutyl ethers of ethylene glycol, propylene glycol, or its ethers, such as the monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, and dipropylene glycol, and alkyl ethers of diethylene glycol, such as the monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propanediol, and glycerin. The organic solvent may be a volatile or non-volatile compound.

[0076] Further non-limiting examples of water-soluble solvents include alkanediols (polyhydric alcohols) such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, (caprylyl glycol), 1,2-hexanediol, 1,2-pentanediol, and 4-methyl-1,2-pentanediol; alkyl alcohols having 1 to 4 carbon atoms such as ethanol, methanol, butanol, propanol, and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, and diethylene glycol mono-n-propyl ether. glycol ethers such as ethylene glycol mono-isopropyl ether, diethylene glycol mono-isopropyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1-methyl-1-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-isopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, and dipropylene glycol mono-isopropyl ether; 2-pyrrolidone, N-methyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolidinone, formamide, acetamide, dimethyl sulfoxide, sorbit, sorbitan, acetin, diacetin, triacetin, sulfolane, and mixtures thereof.

[0077] Polyhydric alcohols are also useful. Examples of polyhydric alcohols include glycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, and mixtures thereof. Polyol compounds may also be used. Non-limiting examples include aliphatic diols such as 2-ethyl-2-methyl-1,3-propanediol, 3,3-dimethyl-1,2-butanediol, 2,2-diethyl-1,3-propanediol, 2-methyl-2-propyl-1,3-propanediol, 2,4-dimethyl-2,4-pentanediol, 2,5-dimethyl-2,5-hexanediol, 5-hexene-1,2-diol, and 2-ethyl-1,3-hexanediol, and mixtures thereof.

[0078] In some examples, the cosmetic compositions of the present disclosure include one or more water-soluble solvents selected from the group consisting of one or more glycols and / or one or more alcohols, such as butylene glycol, capryloyl glycol, propanediol, glycerin, and mixtures thereof.

[0079] The total amount of the one or more water-soluble solvents can and does vary, but is typically about 1 to about 20 wt. % based on the total weight of the cosmetic composition. In some cases, the total amount of the one or more water-soluble solvents may be about 1 to about 15 wt. %, about 1 to about 10 wt. %, about 1 to about 5 wt. %, about 2 to about 20 wt. %, about 2 to about 15 wt. %, about 2 to about 10 wt. %, about 2 to about 5 wt. %, about 5 to about 20 wt. %, about 5 to about 15 wt. %, or about 5 to about 10 wt. % based on the total weight of the cosmetic composition.

[0080] Miscellaneous ingredients The cosmetic composition of the present disclosure may optionally contain one or more miscellaneous ingredients. The miscellaneous ingredients are ingredients that are compatible with the cosmetic composition and do not destroy or substantially affect the basic and novel properties of the cosmetic composition. Miscellaneous ingredients commonly used in cosmetics are known in the art. Non-limiting examples include miscellaneous emulsifiers / surfactants other than (c) one or more first emulsifiers selected from polyglycerol-based emulsifiers, (d) one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6, and (e) one or more third emulsifiers selected from ethoxylated fatty acids, preservatives, fragrances, pH adjusters, salts, buffers, antioxidants, flavonoids, vitamins, plant extracts, UV filters, proteins, protein hydrolysates and / or isolates, hydrotropes, pearlizing agents, fillers, colorants, matting agents, additional skin active agents, bleaching agents, anti-wrinkle agents, etc. Non-limiting examples of various miscellaneous ingredients that may optionally be included (or excluded) from the cosmetic composition are provided below.

[0081] Miscellaneous emulsifiers / surfactants Miscellaneous emulsifiers / surfactants may optionally be included in the cosmetic composition. The miscellaneous emulsifiers / surfactants are other than (c) one or more first emulsifiers selected from polyglycerol-based emulsifiers, (d) one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6, and (e) one or more tertiary emulsifiers selected from ethoxylated fatty acids. The miscellaneous emulsifiers / surfactants may be nonionic, anionic, cationic, and / or amphoteric / zwitterionic.

[0082] antioxidants Examples of antioxidants include tocopherols (e.g., d-α-tocopherol, d-β-tocopherol, d-γ-tocopherol, d-δ-tocopherol), tocotrienols (e.g., d-α-tocotrienol, d-β-tocopherol, d-γ-tocotrienol, d-δ-tocotrienol), and vitamin E (α-tocopherol acetate). These compounds may be isolated from natural sources, prepared by synthetic means, or mixtures thereof. Tocotrienol-enriched vitamin E preparations may be obtained by fractionating a vitamin E preparation to remove a portion of the tocopherols and recovering a preparation enriched in tocotrienols. Useful tocotrienols are natural products isolated, for example, from wheat germ oil, cereal, or palm oil using high-performance liquid chromatography, or from barley, distiller's grain, or oats by alcohol extraction and / or molecular distillation. As used herein, the term "tocotrienol" includes tocotrienol-rich fractions obtained from these natural products as well as pure compounds. Increased glutathione peroxidase activity protects the skin from oxidative damage.

[0083] Vitamin C and derivatives may be used, including ascorbic acid, sodium ascorbate, and the fat-soluble esters tetrahexyldecyl ascorbate and ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl glucoside, glucosamine ascorbate, ascorbyl acetate, etc. Additionally, extracts from plants containing high amounts of vitamin C, such as camu berry (Myrciaria dubia), acerola, emblica officinalis, and bioflavonoids from rose hips and citrus fruits, may also be used, as may those containing water-soluble bioflavonoids such as hesperidin methyl chalcone.

[0084] Sesame seeds (Sesamum indicum) or sesame lignans may be added. Sesame seeds and their lignans (fibrous compounds related to sesame) act as antioxidants. Sesame seed lignans significantly enhance vitamin E activity.

[0085] Additionally, carotenoids, especially xanthophylls, are also useful antioxidants that can be used. Xanthophylls include molecules such as lutein, canthaxanthin, cryptoxanthin, zeaxanthin, and astaxanthin. Xanthophylls protect compounds such as vitamin A, vitamin E, and other carotenoids.

[0086] Flavonoids can also function as antioxidants. In some examples, the flavonoid is a flavanone (a derivative of 2,3-dihydro-2-phenylchromen-4-one). Flavones include butin, eriodictyol, hesperetin, hesperidin, homoeriodictyol, isosakuranetin, naringenin, naringin, pinocembrin, poncirin, sakuranetin, sakuranin, and sterubin. The flavonoid may be a flavanonol (a derivative of 3-hydroxy-2,3-dihydro-2-phenylchromen-4-one). Flavanols include taxifolin, aromadedrin, chrysandroside A, chrysandroside B, xeractinol, astilbin, and fustin. The flavonoid may be a flavone (a derivative of 2-phenylchromen-4-one). Flavones include apigenin, luteolin, tangeritin, chrysin, baicalein, scutellarein, wogonin, and the synthetic flavone diosmin and flavoxate. Flavonoids may also be flavonols (derivatives of 3-hydroxy-2-phenylchromen-4-one). Flavonols include 3-hydroxyflavone, azaleatin, fisetin, galangin, gossypetin, kaempferide, kaempferol, isorhamnetin, morin, myricetin, natudaidine, pachypodol, quercetin, rhamnadin, rhamnetin, azalein, hyperoside, isoquercitin, kaempferitrin, myricitrin, quercitrin, robinin, rutin, spireoside, xanthorramnin, amurensin, icariin, and troxerutin. The flavonoid may be a flavan-3-ol (a derivative of 2-phenyl-3,4-dihydro-2H-chromen-3-ol). Flavan-3-ols include catechin, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, epiafzeletin, fisetinidol, giburtinidol, mesquitol, and robinetinidol. The flavonoid may be a flavan-4-ol (a derivative of 2-phenylchroman-4-ol). Flavan-4-ols include apiforol and luteoforol.The flavonoid may be an isoflavone (a derivative of 3-phenylchromen-4-one), which includes genistein, daidzein, biochanin A, formononetin, and the equol metabolite from daidzein.

[0087] The antioxidant may be an anthocyanidin (a derivative of the 2-phenylchromenylium cation), which includes aurantidin, cyanidin, delphinidin, europinidin, luteolinidin, pelargonidin, malvidin, peonidin, petunidin, rosinidin, and xanthones.

[0088] The antioxidant may be a dihydrochalcone (a derivative of 1,3-diphenyl-1-propanone). Dihydrochalcones include phloretin, dihydrochalcone phloretin phloridzin, aspalathin, naringin dihydrochalcone, neohesperidin dihydrochalcone, and nothofagin. Without limiting the mode of action of the present invention, dihydrochalcones may exert their antioxidant effects by reducing reactive free radicals, such as reactive oxygen and nitrogen species.

[0089] The antioxidant may be anthocyanin. Anthocyanins and their derivatives are antioxidants. Anthocyanins include a class of flavonoid compounds, naturally occurring water-soluble compounds that are responsible for the red, purple, and blue colors of many fruits, vegetables, grains, and flowers. Furthermore, anthocyanins are collagenase inhibitors. Inhibition of collagenase helps prevent and reduce wrinkles caused by a decrease in skin collagen, increase skin elasticity, and so on. Anthocyanins may be obtained from any part of various plant sources, such as fruits, flowers, stems, leaves, roots, bark, or seeds. Those skilled in the art will understand that certain parts of plants may contain higher natural levels of anthocyanins, and therefore, those parts will be used to obtain the desired anthocyanins. In some examples, the antioxidant may include one or more betacyanins. Like anthocyanins, betacyanins may be obtained from natural sources and are antioxidants.

[0090] The antioxidant may be a phenylpropanoid (a derivative of cinnamic acid). Phenylpropanoids include cinnamic acid, caffeic acid, ferulic acid, trans-ferulic acid (including its antioxidant pharmacore 2,6-dihydroxyacetophenone), 5-hydroxyferulic acid, sinapic acid, coumaryl alcohol, coniferyl alcohol, sinapyl alcohol, eugenol, chavicol, safrole, p-coumaric acid, and sinapic acid. Without limiting the mode of action of the present invention, phenylpropanoids may neutralize free radicals.

[0091] The antioxidant may be a chalcone (a derivative of 1,3-diphenyl-2-propen-1-one), including butein, okanin, carthamin, malein, sophoradin, xanthohumol, flavokvain A, flavokvain B, flavokavin C, and synthetic safalcones.

[0092] The antioxidant may be a curcuminoid. Curcuminoids include curcumin, desmethoxycurcumin, bis-desmethoxycurcumin, tetrahydrocurcumin, and tetrahydrocurcuminoids. Curcumin and tetrahydrocurcuminoids may be derived from the rhizome of turmeric (Curcuma longa). Tetrahydrocurcumin, a metabolite of curcumin, has been found to be a more potent antioxidant and more stable than curcumin.

[0093] The antioxidant may be a tannin, which includes tannin, terflavin B, glucogallin, D gallic acid, and quercitanic acid.

[0094] The antioxidant may be a stilbenoid. Stilbenoids include resveratrol, pterostilbene, and piceatannol. Resveratrol may include, but is not limited to, 3,5,4'-trihydroxystilbene, 3,4,3',5'-tetrahydroxystilbene (piceatannol), 2,3',4,5'-tetrahydroxystilbene (oxyresveratrol), 4,4'-dihydroxystilbene, and their alpha and beta glucoside, galactoside, and mannoside derivatives.

[0095] The antioxidant may be a coumarin (a derivative of 2H-chromen-2-one), which includes 4-hydroxycoumarin, umbelliferone, esculetin, herniarin, auraptene, and dicoumarol.

[0096] The antioxidant may be a carotenoid. Carotenoids include beta-carotene, alpha-carotene, gamma-carotene, beta-cryptoxanthin, lycopene, lutein, and idebenone. Sesame (Sesamum indicum) or sesame lignans may also be added. Sesame and its lignans (fibrous compounds related to sesame) act as antioxidants. Sesame seed lignans significantly enhance vitamin E activity.

[0097] Antioxidants include xanthone, butylated hydroxytoluene, 2,6-di-tert-butylphenol, 2,4-dimethyl-6-tert-butylphenol, gallic acid, eugenol, uric acid, alpha-lipoic acid, ellagic acid, chicoric acid, chlorogenic acid, rosmarinic acid, salicylic acid, acetylcysteine, S-allylcysteine, barbigeron, chebulazinic acid, edaravone, ethoxyquin, glutathione, hydroxytyrosol, idebenone, melatonin, N-acetylserotonin, and nor Dihydroguaiaretic acid, oleocanthal, oleuropein, paradol, piceatannol, probucol, propyl gallate, protocatechuic acid, pyritinol, rutin, secoisolariciresinol diglucoside, sesamin, sesamol, silibinin, silymarin, theaflavin, theaflavin digallate, thmoquinone, trolox, tyrosol, polyunsaturated fatty acids, and sulfur-based antioxidants such as methionine or lipoic acid.

[0098] Skin activators Non-limiting examples of skin active agents include retinoic acid, benzoyl peroxide, sulfur, vitamin B6 (pyridoxine or) chloride, selenium, samphire-cinnamon extract blend, tea and octanoylglycine, such as Seppic 15 Sepicontrol A5 TEA, a mixture of cinnamon, sarcosine and octanoylglycine sold by Seppic, especially under the trade name Sepicontrol A5; zinc salts, such as zinc gluconate, zinc pyrrolidone carboxylate (or zinc pidolate), zinc lactate, zinc aspartate, zinc carboxylate, zinc salicylate 20, zinc cysteine; derivatives, especially copper as Cuivridone Solabia and copper pidolate; and the extracts of Arnica montana, Cinchona succirubra, Eugenia caryophyllata, hops (Humulus ulmoides), and the like. lupulus, St. John's Wort (Hypericum perforatum), Mentha pipenta, Rosemary (Rosmarinus officinalis), Sage (Salvia officinalis) and Thymus vulgaris, all sold, for example, by Maruzen; extracts of Spiraea ulmaria, for example, sold under the name Sebonormine by Silab; extracts of the alga Laminaria saccharina, for example, sold under the name Phlorogine by Biotechmarine; extracts of the roots of Sanguisorba officinalis / Poterium officinale, ginger (Zingiber officinalis) rhizome and cinnamon bark (Cinnamomum cassia), e.g., sold under the name Sebustop by Solabia; extracts of flaxseed, e.g., LucasMeyer sells under the name Linumine - Phellodendron extract, for example sold under the name Phellodendron Extract BG by Maruzen or sold under the name Phellodendron Liquid B by Ichimaru Falcos - Serenoa serrulata (saw palmetto) extract and sesame seed argan oil mixture extract, for example sold under the name Regu SEB by Pentapharm - a mixture of extracts of willow herb, myrobalan (Terminalia chebula), nasturtium and bioavailable zinc (microalgae), for example sold under the name Seborilys Green Tech; Pygeum afrianum extract, for example sold under the name Pygeum afrianum sterolic lipid extract by Euromed - Serenoa serrulata serrulata extract, such as that sold under the name Viapure Sabal by Actives International and sold by Euromed; plantain blend, extract of Berberis aquifolium and sodium salicylate 20, such as that sold under the name Seboclear Rahn; clove extract as sold under the name Clove extract powder by Maruzen; argan oil, such as that sold under the name Lipofructyl Laboratories Serobiologiques; 25 lactic acid protein filtrate, such as that sold under the name Noraseb by Sederma; seaweed kelp extract, such as that sold under the name Laminarghane by Biotechmarine; oligosaccharide seaweed Laminaria digitata, such as Phycosaccharide 30 by Codif.These include sugarcane extracts, such as those sold under the name Policosanol by Sabinsa, sulfonated shale oil, such as those sold under the name Ichtyol Pale by Ichthyol, extracts of meadowsweet (Spiraea ulmaria), such as those sold under the name Cytobiol Ulmaire by societe Libiol, sebacic acid, in particular in the form of a sodium polyacrylate gel sold under the name Sebosoft by Sederma, glucomannan extracted from konjac tubers and modified with alkylsulfonate chains, such as those sold under the name Biopol Beta by Arch Chemical, extracts of Sophora angustifolia, such as those sold under the name Sophora powder or Sophora extract by Bioland, and cinchona bark. succirubra extracts, such as those sold under the name Red Bark HS by Alban Muller; Quillaja saponaria extracts, such as those sold under the name Panama wood HS by Alban Muller 15; glycine grafted onto undecylene chains, such as those sold under the name Lipacide UG OR by SEPPIC; a mixture of oleanolic acid and nordihydroguaiaretic acid, such as those sold in the form of a gel under the name AC.Net by Sederma 20; phthalimidoperoxyhexanoic acid, such as those sold in the form of a gel under the name COSMACOL.RTM by Sasol; Tri(C12-C13) citrate sold under the name ECI; trialkyl citrate (C14-C15) -10-hydroxydecanoic acid (mixture, including hydroxydecanoic acid OCTOBER 25, sebacic acid and 1,10-decanediol), sold under the name COSMACOL.RTM.ECL by Sasol, and mixtures thereof, such as those sold under the name Acnacidol BG by Vincience, are also included.

[0099] bleaching agent Non-limiting examples of depigmenting agents include alpha and beta arbutin, ferulic acid, rucinol and its derivatives, kojic acid, resorcinol and its derivatives, tranexamic acid and its derivatives, gentisic acid, homogentisin, methylgentisate or homogentisate, diacid, D-pantetheine calcium sulfonate, lipoic acid, ellagic acid, vitamin B3, linoleic acid and its derivatives, certain compounds derived from plants such as chamomile, bearberry, aloe (vera, ferox, valdensis), mulberry, skullcap, water kiwi fruit (Actinidia chinensis) sold by Gattefosse, extract of the root of the peony (Paeonia suffruticosa), for example, sold by Ichimaru Falcos under the name Liquid Botanpi Be, brown sugar (Saccharum officinalis), officinarum extracts, such as the molasses extract sold by Taiyo Kagaku under the name "Liquid Molasses," although this list is not exhaustive. Specific depigmenting agents include alpha and beta arbutin, ferulic acid, kojic acid, resorcinol and derivatives, D-pantetheine calcium sulfonate, lipoic acid, ellagic acid, vitamin B3, water kiwi fruit (Actinidia chinensis) sold by Gattefosse, and peony (Paeonia suffruticosa) root extracts, such as that sold by Ichimaru Falcos under the name "Botanpi Liquid B."

[0100] Anti-wrinkle agent The term "anti-wrinkle agent" refers to a natural or synthetic compound that, when contacted with wrinkled skin areas, produces a biological effect, such as increasing the synthesis and / or activity of certain enzymes, which has the effect of reducing the appearance of wrinkles and / or fine lines.Non-limiting examples of anti-wrinkle agents include desquamating agents, anti-glycation agents, inhibitors of NO-synthase, agents that stimulate the synthesis of dermal or epidermal macromolecules and / or prevent their degradation, agents that stimulate the proliferation of fibroblasts and / or keratinocytes, or agents that stimulate keratinocyte differentiation, reducing agents; muscle relaxants and / or skin relaxants, anti-free radical agents, and mixtures thereof. Examples of such compounds are adenosine and its derivatives and retinoids other than retinol (such as retinol palmitate, as mentioned above), ascorbic acid and its derivatives, such as magnesium ascorbyl phosphate and ascorbyl glucoside; nicotinic acid and its precursors, such as nicotinamide; ubiquinone; glutathione and its precursors, such as L-2-oxothiazolidine-4-carboxylic acid, in particular the compounds described in EP 1 345 919, C-glycosides and their derivatives, in particular C-β-D-xylopyranoside-2-hydroxy-propane, as described in EP 1 345 919, Plant extracts including sea fennel and olive leaf extracts, as well as plants and their hydrolysates, such as rice protein hydrolysates or soy protein; algae extracts, especially kelp, bacterial extracts, sapogenins, such as diosgenin, and extracts of Dioscorea plants, especially wild yam, which contain α-hydroxy acids, β-hydroxy acids, such as salicylic acid and n-octanoyl-5-salicylic acid oligopeptides, and pseudodipeptides and their acyl derivatives, especially the acid {2-[acetyl-(3-trifluoromethyl-phenyl)-amino]-3-methyl-}acetic acid, and lipopeptides sold by companies under the trade names SEDERMA Matrixyl 500 and Matrixyl 3000; lycopene, manganese and magnesium salts, especially gluconates, and mixtures thereof.In at least one example, the skin tightening composition includes an adenosine derivative, such as a non-phosphate derivative of adenosine, such as 2'-deoxyadenosine, 2',3'-adenosine isopropylidene; toyocamycine, 1-methyladenosine, N-6-methyladenosine; adenosine N-oxide, 6-methylmercaptopurine riboside, and 6-chloropurine riboside, among others. Other derivatives include adenosine receptor agonists such as adenosine phenylisopropyl ("PIA"), 1-methylisoguanosine, N-cyclohexyladenosine (CHA), N-cyclopentyladenosine (CPA), 2-chloro-N-cyclopentyladenosine, 2-chloroadenosine, N-phenyladenosine, 2-phenylaminoadenosine, MECA, N-phenethyladenosine, 2-p-(2-carboxy-ethyl)phenethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS-21680), N-ethylcarboxamido-adenosine (NECA), 5'(N-cyclopropyl)-carboxamidoadenosine, DPMA (PD129.944), and metrifugil.

[0101] The total amount of one or more miscellaneous ingredients, if present, will vary. Nevertheless, in various embodiments, the total amount of one or more miscellaneous ingredients, if present, is from about 0.01 to about 10 wt. %, based on the total weight of the cosmetic composition. In further embodiments, the total amount of one or more miscellaneous ingredients is from about 0.01 to about 8 wt. %, from about 0.01 to about 5 wt. %, from about 0.01 to about 3 wt. %, from about 0.1 to about 10 wt. %, from about 0.1 to about 8 wt. %, from about 0.1 to about 5 wt. %, from about 0.1 to about 3 wt. %, from about 1 to about 10 wt. %, from about 1 to about 8 wt. %, from about 1 to about 5 wt. %, or from about 1 to about 3 wt. %, based on the total weight of the cosmetic composition.

[0102] As previously mentioned, skin active agents may be included as one or more of the miscellaneous ingredients. With respect to the total amount of skin active agents in the cosmetic composition, if present, the total amount of skin active agents may be, based on the total weight of the cosmetic composition, from greater than 0 to about 9% by weight, greater than 0 to about 8% by weight, greater than 0 to about 7% by weight, greater than 0 to about 6% by weight, greater than 0 to about 5% by weight, greater than 0 to about 4% by weight, greater than 0 to about 3% by weight, greater than 0 to about 2% by weight; from about 10 ppm to about 10% by weight (100,000 ppm), from about 10 ppm to about 5% by weight (50,000 ppm), from about 10 ppm to about 2.5% by weight (25,000 ppm), from about 10 ppm to about 1% by weight (10,000 ppm), from about 10 ppm to about 0.5% by weight (5,000 ppm), from about 10 ppm to about 0.3% by weight (3,000 ppm), from about 10 ppm to about 0.2% by weight Amount% (2,000ppm), about 10ppm to about 0.1% by weight (1,000ppm), about 10ppm to 500ppm; about 0.1 to about 10% by weight, about 0.1 to about 5wt Amount%, about 0.1 to about 2.5% by weight, about 0.1 to about 1% by weight, about 0.1 to about 0.5% by weight; about 1 to about 10% by weight, about 1 to about 8% by weight, about 1 to about 6% by weight, about 1 to about 5% by weight, about 1 to about 4% by weight, about 1 to about 3% by weight; about 2 to about 10% by weight, about 2 to about 8% by weight, about 2 to about 6% by weight, about 2 to about 5% by weight, about 2 to about 4% by weight; about 3 to about 10% by weight, about 3 to about 8% by weight, about 3 to about 6% by weight, about 3 to about 5% by weight; about 4 to about 10% by weight, about 4 to about 8% by weight, or about 4 to about 6% by weight.

[0103] pH In certain embodiments, the cosmetic composition preferably has a pH of less than 7.0. In further embodiments, the cosmetic composition has a pH of about 4.0 to less than 7.0, about 4.5 to less than 7.0, about 5.0 to less than 7.0, about 6.0 to less than 7.0, about 4.0 to about 6.5, about 4.5 to about 6.5, about 5.0 to about 6.5, or about 5.0 to about 6.0. In various embodiments, the pH of the cosmetic composition does not change by more than ±1 pH unit, ±0.5 pH unit, ±0.3 pH unit, or ±0.2 pH unit for at least 2 weeks, 4 weeks, and / or 8 weeks upon storage at 4°C, 25°C, 37°C, and / or 45°C.

[0104] weight ratio In various embodiments, the cosmetic composition preferably comprises one or more ratios of components (a) and (c) through (g).

[0105] In one embodiment, the weight ratio of the one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs is from about 1.5:1 to about 8:1 ((c):(a)), preferably from about 1.5:1 to about 5:1, and more preferably from about 1.5:1 to about 3:1.

[0106] In one embodiment, the weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP is about 0.8:1 to about 4:1 ((d):(a)), preferably 1:1 to about 3:1, and more preferably about 1.2:1 to about 2.5:1.

[0107] In one embodiment, the weight ratio of the one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NPs is from about 0.7:1 to about 4:1 ((e):(a)), preferably from about 0.8:1 to about 3:1, and more preferably from about 0.8:1 to about 2.5:1.

[0108] In one embodiment, the weight ratio of one or more fatty alcohols to ceramide NPs is from about 0.7:1 to about 4:1 ((f):(a)), preferably from about 0.8:1 to about 3:1, and more preferably from about 0.8:1 to about 2.5:1.

[0109] In one embodiment, the weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NPs is about 4:1 to about 20:1 ((g):(a)), preferably about 5:1 to 15:1, and more preferably about 6:1 to 10:1.

[0110] In a preferred embodiment, the cosmetic composition comprises the following ratios for components (a) and (c)-(g): the weight ratio of the one or more first emulsifiers selected from polyglycerol-based emulsifiers to the ceramide NPs is about 1.5:1 to about 8:1 ((c):(a)), preferably about 1.5:1 to about 5:1, more preferably about 1.5:1 to about 3:1; the weight ratio of the one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to the ceramide NP is about 0.8:1 to about 4:1 ((d):(a)), preferably 1:1 to about 3:1, and more preferably about 1.2:1 to about 2.5:1; the weight ratio of the one or more third emulsifiers selected from ethoxylated fatty acids to the ceramide NP is from about 0.7:1 to about 4:1 ((e):(a)), preferably from about 0.8:1 to about 3:1, and more preferably from about 0.8:1 to about 2.5:1; the weight ratio of the one or more fatty alcohols to the ceramide NP is from about 0.7:1 to about 4:1 ((f):(a)), preferably from about 0.8:1 to about 3:1, more preferably from about 0.8:1 to about 2.5:1; and The weight ratio of the one or more non-triglyceride and non-aromatic fatty compounds to the ceramide NP is about 5:1 to about 20:1 ((g):(a)), preferably about 5:1 to 15:1, more preferably about 6:1 to 10:1.

[0111] stability The cosmetic compositions of the present disclosure are stable, and the ceramide NPs are solubilized. With regard to stability, in certain embodiments, the cosmetic compositions do not visually phase separate or form visually observable particulates upon storage at 4°C, 25°C, 37°C, and / or 45°C for at least 2 weeks, 4 weeks, and / or 8 weeks.

[0112] In another embodiment, the cosmetic composition does not visually phase separate or form visually observable particulates during at least 10 cycles of freeze-thaw testing, wherein the freeze-thaw testing comprises placing the cosmetic composition in a stability chamber and subjecting it to temperature fluctuations at 12 hour intervals, with a first interval of 12 hours at −20° C., followed by a second interval of 12 hours at 25° C.

[0113] In another embodiment, the viscosity of the cosmetic composition does not change by more than 20%, 15%, 10%, or 5% for at least 2 weeks, 4 weeks, and / or 8 weeks upon storage at 4°C, 25°C, 37°C, and / or 45°C.

[0114] With respect to ceramide NPs, in various embodiments, at least 80%, 85%, 90%, 95%, or 98% of the ceramide NPs remain solubilized for at least 2 weeks, 4 weeks, and / or 8 weeks upon storage at 4° C., 25° C., 37° C., and / or 45° C. The lack of visually observable phase separation and microparticle formation (discussed above) also indicates that the ceramide NPs remain solubilized.

[0115] viscosity Generally, the cosmetic composition of this example has a viscosity of about 5,000 to about 200,000 Pa.s at 25°C and a viscosity of 1 s at 25°C. -1 However, the cosmetic composition has a shear rate of about 10,000 to about 200,000 Pa.s, about 10,000 to about 180,000 Pa.s, about 10,000 to about 150,000 Pa.s, about 10,000 to about 120,000 Pa.s, about 15,000 to about 200,000 Pa.s, about 15,000 to about 180,000 Pa.s, about 15,000 to about 150,000 Pa.s, about 15,000 to about 120,000 Pa.s, about 20,000 to about 200,000 Pa.s, about 20,000 to about 180,000 Pa.s, about 20,000 a viscosity of 0 to about 150,000 Pa.s, about 20,000 to about 120,000, about 50,000 to about 200,000 Pa.s, about 50,000 to about 180,000 Pa.s, about 50,000 to about 150,000 Pa.s, about 50,000 to about 120,000 Pa.s, about 70,000 to about 200,000 Pa.s, about 70,000 to about 180,000 Pa.s, about 70,000 to about 150,000 Pa.s, about 70,000 to about 120,000 Pa.s, or about 70,000 to about 100,000 Pa.s, and a viscosity of 1 s at 25°C -1 The shear rate may be

[0116] Viscosity measurements may be performed using a Brooksfield viscometer / rheometer using a t-bar spindle at speeds of, for example, 5, 10, 15, and / or 20 rpm. An RVDV-II+ Pro viscometer with RheocalcT software may be used for automated instrument control and data collection. The test temperature is maintained at 25°C using a Brookfield TC-502P programmable cooling bath. From its original container, the sample is transferred to a 120 mL glass jar and then tested.

[0117] method The present disclosure relates to a method for treating skin. The method includes applying a cosmetic composition according to the present disclosure and optionally leaving the cosmetic composition on the skin for a certain period of time. The cosmetic composition is typically applied directly to the skin using hands or a cloth. The skin may be optionally washed or rinsed before application. The method for treating skin may be performed once a day or multiple times. For example, the method for treating skin may be performed once a day, twice a day, weekly, or every other week for a long period of time, for example, from about 1, 2, 3, 4, 5, or 6 months to up to 1 year or more.

[0118] In various embodiments, the method hydrates the skin and / or improves the skin's natural lipid barrier, providing maintenance of moisture balance, relief / reduction of itching, chronic dryness, peeling, and scaling, and is useful in the treatment of dry and aging skin. In further embodiments, when the composition includes hydroxypropyltetrahydropyrantriol, the method reduces the appearance of fine lines and wrinkles, improves hyaluronic acid production through stimulation of glycosaminoglycan (GAG) synthesis, and softens the stratum corneum, reducing cumulative stress on the epidermis and dermis.

[0119] In certain embodiments, the method further comprises mixing the cosmetic composition of the present disclosure with one or more additional cosmetic compositions before application to the skin. For example, the cosmetic composition of the present disclosure can be mixed with one or more additional cosmetic compositions immediately before application to the skin, and for example, the mixing can be performed within 1 minute, 2 minutes, 5 minutes, 10 minutes, 15 minutes, or 30 minutes before application to the skin. In certain embodiments, the cosmetic composition can be mixed by an individual's hands before applying the mixture to the skin, for example, facial skin.

[0120] The present disclosure also relates to a method for stabilizing a cosmetic composition containing a large amount of ceramide NPs, which method comprises combining ceramide NPs according to the composition of this example. The amount of ceramide NPs that may be included is the amount indicated throughout this disclosure.

[0121] In various embodiments, the present disclosure relates to methods for stabilizing cosmetic compositions containing large amounts of ceramide NPs. In various embodiments, the present disclosure relates to preserving and / or stabilizing ceramide NPs in cosmetic compositions, resulting in cosmetic compositions containing large amounts of ceramide NPs that preserve (maintain) and stabilize the large amounts of ceramide NPs over time.

[0122] kit The cosmetic compositions of the present disclosure may be provided in a kit, for example, a kit including a separately contained cosmetic composition according to the present disclosure and one or more additional separately contained cosmetic compositions. In one embodiment, the one or more separately contained compositions may be additional compositions according to the present disclosure or may be different compositions. The cosmetic compositions may be separately contained in different cartridges contained in a dispensing apparatus / device. In other words, the kit may be a dispensing apparatus / device including multiple cartridges containing the compositions. The kit (or apparatus / device) may optionally dispense the cosmetic composition of the present disclosure and one or more separately contained compositions. In various embodiments, the compositions may be dispensed separately or simultaneously, and may (or may not) be optionally mixed with each other before being dispensed. In one embodiment, the various compositions are not mixed with each other before being dispensed. Useful systems, cartridges, and dispensing apparatus / devices are disclosed in U.S. Patent Nos. 9,968,177 and 9,808,071; U.S. Patent Application Publication Nos. 2021 / 0236390, 2021 / 0235849, and 2021 / 0236863; and U.S. Patent Application No. 17 / 162,555, all of which are incorporated by reference in their entireties.

[0123] Embodiment In certain embodiments, the cosmetic compositions of the present disclosure comprise: (a) about 0.1 to about 5 wt %, preferably about 0.1 to about 3 wt %, more preferably about 0.2 to about 2 wt %, and even more preferably about 0.3 to about 1.5 wt % of ceramide NP; (b) about 50 to about 90% by weight, preferably about 55 to about 80% by weight, more preferably about 55 to about 75% by weight, of water; (c) about 0.5 to about 5 wt. %, more preferably about 0.5 to about 4 wt. %, and even more preferably about 0.8 to about 3 wt. % of a polyglycerol emulsifier, preferably one or more polyglyceryl esters of C12-22 saturated, unsaturated and branched chain fatty acids, such as polyglyceryl-4 isostearate, polyglyceryl-3 oleate, polyglyceryl-2-sesquioleate, triglyceryl diisostearate, diglyceryl monooleate, tetraglyceryl monooleate, and mixtures thereof; and / or one or more polyglyceryl methyl glucose surfactants, such as polyglyceryl-3 methyl glucose distearate, polyglyceryl-6 methyl glucose distearate, polyglyceryl-10 methyl glucose distearate one or more first emulsifiers selected from (d) about 0.5 to about 5% by weight, more preferably about 0.5 to about 4% by weight, and even more preferably about 0.8 to about 3% by weight of, preferably bis-diglyceryl polyacyladipate-2, glyceryl behenate, glyceryl caprate, glyceryl cocoate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl palmitate, one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 selected from glyceryl esters selected from glyceryl esters of ... (e) from about 0.5 to about 5% by weight, preferably from about 0.5 to about 4% by weight, more preferably from about 0.5 to about 3% by weight of one or more third emulsifiers, preferably selected from ethoxylated fatty acids derived from fatty acids containing from 8 to 24 carbon atoms and having from 2 to 200 molecules of ethylene oxide, more preferably selected from polyethoxylated stearic acid esters, such as PEG-9 stearate, PEG-8 distearate, PEG-20 stearate, PEG-8 stearate, PEG-8 oleate, PEG-20 stearate, PEG-30 stearate, PEG-40 stearate, PEG-50 stearate, PEG-100 stearate, PEG-150 laurate, and mixtures thereof; (f) from about 0.2 to about 5% by weight, preferably from about 0.3 to about 4% by weight, more preferably from about 0.5 to about 3% by weight of one or more fatty alcohols, preferably having 10 to 30 carbon atoms, more preferably selected from decyl alcohol, undecyl alcohol, dodecyl, myristyl, cetyl alcohol, stearyl alcohol, cetearyl alcohol, isostearyl alcohol, isocetyl alcohol, behenyl alcohol, linalool, oleyl alcohol, myricyl alcohol, and mixtures thereof; (g) about 4 to about 20% by weight, preferably about 4 to about 15% by weight, more preferably about 5 to about 10% by weight, of one or more non-triglyceride and non-aromatic fatty compounds, preferably selected from fatty esters (e.g., isopropyl myristate, sorbitan isostearate), acyl sarcosinates, oils, alkanes (paraffins), fatty acids, fatty alcohol derivatives, fatty acid derivatives, waxes, lanolin, and mixtures thereof, preferably selected from fatty ester acyl sarcosinates, and mixtures thereof; (h) optionally, hydroxypropyltetrahydropyrantriol (if present, preferably in an amount of about 10 to about 40% by weight, more preferably about 10 to about 20% by weight, more preferably about 12 to about 18% by weight); (i) optionally, one or more thickening polymers (if present, which may be in an amount of about 0.01 to about 5 wt. %, preferably about 0.1 to about 4 wt. %, more preferably about 0.1 to about 3 wt. %), such as polyacrylates (e.g., sodium polyacrylate), hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, acrylamide / sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, polyacrylamide, acrylate c10-30 alkyl acrylate crosspolymer, and mixtures thereof; (j) optionally, one or more water-soluble solvents (if present, which may be in an amount of about 1 to about 20% by weight, preferably about 1 to about 15% by weight, more preferably about 5 to about 15% by weight), such as glycerin, C2-C6 monoalcohols, polyols (polyhydric alcohols), glycols, and mixtures thereof; (k) optionally, one or more miscellaneous ingredients (if present, which may be in an amount of about 0.01 to about 10% by weight, preferably about 0.1 to about 8% by weight, more preferably about 1 to about 6% by weight), such as miscellaneous ingredients selected from miscellaneous emulsifiers / surfactants, preservatives, fragrances, pH adjusters, salts, antioxidants, vitamins, botanical extracts, UV filters, proteins, protein hydrolysates and / or isolates, hydrotropes, pearlizing agents, fillers, colorants, matting agents, additional skin active agents, buffers, and mixtures thereof; comprising or consisting of The compositions are oil-in-water emulsions and all weight percentages are based on the total weight of the composition.

[0124] In addition to the various amounts of components (a) and (c)-(g) described above, in various embodiments, the cosmetic composition preferably comprises one or more ratios of components (a) and (c)-(g) selected from the following: a weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs of from about 1.5:1 to about 8:1 ((c):(a)), preferably from about 1.5:1 to about 5:1, and more preferably from about 1.5:1 to about 3:1; a weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP of about 0.8:1 to about 4:1 ((d):(a)), preferably 1:1 to about 3:1, and more preferably about 1.2:1 to about 2.5:1; a weight ratio of one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NP of about 0.7:1 to about 4:1 ((e):(a)), preferably about 0.8:1 to about 3:1, and more preferably about 0.8:1 to about 2.5:1; a weight ratio of one or more fatty alcohols to ceramide NPs of about 0.7:1 to about 4:1 ((f):(a)), preferably about 0.8:1 to about 3:1, and more preferably about 0.8:1 to about 2.5:1; A weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NPs of about 4:1 to about 20:1 ((g):(a)), preferably about 5:1 to 15:1, more preferably about 6:1 to 10:1.

[0125] In a preferred embodiment, the cosmetic composition comprises the following ratios with respect to all of components (a) and (c)-(g): the weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs is from about 1.5:1 to about 8:1 ((c):(a)), preferably from about 1.5:1 to about 5:1, more preferably from about 1.5:1 to about 3:1; the weight ratio of the one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to the ceramide NP is about 0.8:1 to about 4:1 ((d):(a)), preferably 1:1 to about 3:1, and more preferably about 1.2:1 to about 2.5:1; the weight ratio of the one or more third emulsifiers selected from ethoxylated fatty acids to the ceramide NP is from about 0.7:1 to about 4:1 ((e):(a)), preferably from about 0.8:1 to about 3:1, and more preferably from about 0.8:1 to about 2.5:1; the weight ratio of the one or more fatty alcohols to the ceramide NP is from about 0.7:1 to about 4:1 ((f):(a)), preferably from about 0.8:1 to about 3:1, more preferably from about 0.8:1 to about 2.5:1; and The weight ratio of the one or more non-triglyceride and non-aromatic fatty compounds to the ceramide NP is about 4:1 to about 20:1 ((g):(a)), preferably about 5:1 to 15:1, more preferably about 6:1 to 10:1.

[0126] The cosmetic compositions of the present disclosure are preferably stable, and the ceramide NPs are preferably solubilized. With regard to stability, in certain embodiments, the cosmetic compositions do not visually phase separate or form visually observable particulates upon storage at 4°C, 25°C, 37°C, and / or 45°C for at least 2 weeks, 4 weeks, and / or 8 weeks.

[0127] In another embodiment, the cosmetic composition does not visually phase separate or form visually observable particulates during at least 10 cycles of freeze-thaw testing, wherein the freeze-thaw testing comprises placing the cosmetic composition in a stability chamber and subjecting it to temperature fluctuations at 12 hour intervals, with a first interval of 12 hours at −20° C., followed by a second interval of 12 hours at 25° C.

[0128] In another embodiment, the viscosity of the cosmetic composition does not change by more than 20%, 15%, 10%, or 5% for at least 2 weeks, 4 weeks, and / or 8 weeks upon storage at 4°C, 25°C, 37°C, and / or 45°C.

[0129] The cosmetic composition preferably has a viscosity of about 5,000 to about 200,000 Pa.s at 25°C, and a viscosity of 1 s at 25°C. -1However, the cosmetic composition has a shear rate of about 10,000 to about 200,000 Pa.s, about 10,000 to about 180,000 Pa.s, about 10,000 to about 150,000 Pa.s, about 10,000 to about 120,000 Pa.s, about 15,000 to about 200,000 Pa.s, about 15,000 to about 180,000 Pa.s, about 15,000 to about 150,000 Pa.s, about 15,000 to about 120,000 Pa.s, about 20,000 to about 200,000 Pa.s, about 20,000 to about 180,000 Pa.s, about 20,000 a viscosity of 0 to about 150,000 Pa.s, about 20,000 to about 120,000, about 50,000 to about 200,000 Pa.s, about 50,000 to about 180,000 Pa.s, about 50,000 to about 150,000 Pa.s, about 50,000 to about 120,000 Pa.s, about 70,000 to about 200,000 Pa.s, about 70,000 to about 180,000 Pa.s, about 70,000 to about 150,000 Pa.s, about 70,000 to about 120,000 Pa.s, or about 70,000 to about 100,000 Pa.s, and a viscosity of 1 s at 25°C -1 The shear rate may be

[0130] In certain embodiments, the cosmetic composition of the present disclosure comprises: (a) about 0.5 to about 5% by weight, preferably about 0.5 to about 3% by weight, of ceramide NP; (b) about 50 to about 80% by weight, preferably about 60 to 80% by weight, of water; (c) from about 0.1 to about 5% by weight, preferably from about 0.5 to about 4% by weight, of one or more first emulsifiers selected from polyglyceryl 10-stearate, polyglyceryl-3-caprate, polyglyceryl-3-diisostearate, polyglyceryl-3 methylglucose distearate, and mixtures thereof; (d) about 0.5 to about 5% by weight, preferably about 0.5 to about 4% by weight, more preferably about 0.5 to about 3% by weight, of, for example, bis-diglyceryl polyacyladipate-2, glyceryl behenate, glyceryl caprate, glyceryl cocoate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl palmitate lactate, glyceryl selenite, one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 10 selected from glyceryl stearate, glyceryl stearate citrate, glyceryl stearate lactate, glyceryl dioleate, glyceryl distearate, glyceryl laurate, or mixtures thereof; in at least one example, the glyceryl esters include glyceryl stearate, bis-diglyceryl polyacyladipate, glyceryl ricinoleate, or mixtures thereof; (e) about 0.5 to about 5% by weight, preferably about 0.5 to about 4% by weight, more preferably about 0.5 to about 3% by weight of one or more third emulsifiers selected from ethoxylated fatty acids having propylene oxide groups in the range of 40 to 100 and a fatty chain of 8 to 24 carbon atoms, preferably selected from polyethoxylated stearic acid esters such as PEG-9 stearate, PEG-8 distearate, PEG-20 stearate, PEG-8 stearate, PEG-8 oleate, PEG-20 stearate, PEG-30 stearate, PEG-40 stearate, PEG-50 stearate, PEG-100 stearate, PEG-150 laurate, and mixtures thereof; (f) from about 0.2 to about 5% by weight, preferably from about 0.3 to about 4% by weight, and more preferably from about 0.5 to about 3% by weight of one or more fatty alcohols having 8 to 24 carbon atoms, preferably selected from decyl alcohol, undecyl alcohol, dodecyl, myristyl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, isostearyl alcohol, isocetyl alcohol, behenyl alcohol, and mixtures thereof; (g) about 4 to about 20% by weight, preferably about 4 to about 15% by weight, and more preferably about 5 to about 10% by weight of one or more non-triglyceride and non-aromatic fatty compounds selected from fatty esters, acyl sarcosinates, or mixtures thereof; (h) optionally, hydroxypropyltetrahydropyrantriol (if present, preferably in an amount of about 10 to about 40% by weight, more preferably about 10 to about 20% by weight, more preferably about 12 to about 18% by weight); (i) optionally, one or more thickening polymers (if present, which may be in an amount of about 0.01 to about 5 wt. %, preferably about 0.1 to about 4 wt. %, more preferably about 0.1 to about 3 wt. %), such as polyacrylates (e.g., sodium polyacrylate), hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, acrylamide / sodium acryloyldimethyl taurate copolymer, polyacrylate crosspolymer-6, polyacrylamide, acrylate c10-30 alkyl acrylate crosspolymer, and mixtures thereof; (j) about 1 to about 15% by weight of one or more water-soluble solvents selected from glycerin, C2-C6 monoalcohols, polyols (polyhydric alcohols), glycols, and mixtures thereof; and (k) optionally, one or more miscellaneous ingredients (if present, which may be in an amount of about 0.01 to about 10% by weight, preferably about 0.1 to about 8% by weight, more preferably about 1 to about 6% by weight), such as miscellaneous ingredients selected from miscellaneous emulsifiers / surfactants, preservatives, fragrances, pH adjusters, salts, antioxidants, vitamins, botanical extracts, UV filters, proteins, protein hydrolysates and / or isolates, hydrotropes, pearlizing agents, fillers, colorants, matting agents, additional skin active agents, buffers, and mixtures thereof; may comprise or consist of The compositions are oil-in-water emulsions and all weight percentages are based on the total weight of the composition.

[0131] In addition to the various amounts of components (a) and (c)-(g) described above, in various embodiments, the cosmetic composition preferably comprises one or more ratios of components (a) and (c)-(g) selected from the following: a weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs of from about 1.5:1 to about 8:1 ((c):(a)), preferably from about 1.5:1 to about 5:1, and more preferably from about 1.5:1 to about 3:1; a weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP of about 0.8:1 to about 4:1 ((d):(a)), preferably 1:1 to about 3:1, and more preferably about 1.2:1 to about 2.5:1; a weight ratio of one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NP of about 0.7:1 to about 4:1 ((e):(a)), preferably about 0.8:1 to about 3:1, and more preferably about 0.8:1 to about 2.5:1; a weight ratio of one or more fatty alcohols to ceramide NPs of about 0.7:1 to about 4:1 ((f):(a)), preferably about 0.8:1 to about 3:1, and more preferably about 0.8:1 to about 2.5:1; A weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NPs of about 4:1 to about 20:1 ((g):(a)), preferably about 5:1 to 15:1, more preferably about 6:1 to 10:1.

[0132] In a preferred embodiment, the cosmetic composition comprises the following ratios with respect to all of components (a) and (c)-(g): the weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs is from about 1.5:1 to about 8:1 ((c):(a)), preferably from about 1.5:1 to about 5:1, more preferably from about 1.5:1 to about 3:1; the weight ratio of the one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to the ceramide NP is about 0.8:1 to about 4:1 ((d):(a)), preferably 1:1 to about 3:1, and more preferably about 1.2:1 to about 2.5:1; the weight ratio of the one or more third emulsifiers selected from ethoxylated fatty acids to the ceramide NP is from about 0.7:1 to about 4:1 ((e):(a)), preferably from about 0.8:1 to about 3:1, and more preferably from about 0.8:1 to about 2.5:1; the weight ratio of the one or more fatty alcohols to the ceramide NP is from about 0.7:1 to about 4:1 ((f):(a)), preferably from about 0.8:1 to about 3:1, more preferably from about 0.8:1 to about 2.5:1; and The weight ratio of the one or more non-triglyceride and non-aromatic fatty compounds to the ceramide NP is about 1:1 to about 20:1 ((g):(a)), preferably about 2:1 to 20:1, more preferably about 2:1 to 10:1.

[0133] The cosmetic compositions of the present disclosure are preferably stable, and the ceramide NPs are preferably solubilized. With regard to stability, in certain embodiments, the cosmetic compositions do not visually phase separate or form visually observable particulates upon storage at 4°C, 25°C, 37°C, and / or 45°C for at least 2 weeks, 4 weeks, and / or 8 weeks.

[0134] In another embodiment, the cosmetic composition does not visually phase separate or form visually observable particulates during at least 10 cycles of freeze-thaw testing, wherein the freeze-thaw testing comprises placing the cosmetic composition in a stability chamber and subjecting it to temperature fluctuations at 12 hour intervals, with a first interval of 12 hours at −20° C., followed by a second interval of 12 hours at 25° C.

[0135] In another embodiment, the viscosity of the cosmetic composition does not change by more than 20%, 15%, 10%, or 5% for at least 2 weeks, 4 weeks, and / or 8 weeks upon storage at 4°C, 25°C, 37°C, and / or 45°C.

[0136] The cosmetic composition preferably has a viscosity of about 5,000 to about 200,000 Pa.s at 25°C, and a viscosity of 1 s at 25°C. -1 However, the cosmetic composition has a shear rate of about 10,000 to about 200,000 Pa.s, about 10,000 to about 180,000 Pa.s, about 10,000 to about 150,000 Pa.s, about 10,000 to about 120,000 Pa.s, about 15,000 to about 200,000 Pa.s, about 15,000 to about 180,000 Pa.s, about 15,000 to about 150,000 Pa.s, about 15,000 to about 120,000 Pa.s, about 20,000 to about 200,000 Pa.s, about 20,000 to about 180,000 Pa.s, about 20,000 a viscosity of 0 to about 150,000 Pa.s, about 20,000 to about 120,000, about 50,000 to about 200,000 Pa.s, about 50,000 to about 180,000 Pa.s, about 50,000 to about 150,000 Pa.s, about 50,000 to about 120,000 Pa.s, about 70,000 to about 200,000 Pa.s, about 70,000 to about 180,000 Pa.s, about 70,000 to about 150,000 Pa.s, about 70,000 to about 120,000 Pa.s, or about 70,000 to about 100,000 Pa.s, and a viscosity of 1 s at 25°C -1 The shear rate may be [Example]

[0137] It is intended that all matter contained in the above description and in the examples that follow be interpreted as illustrative and not in a limiting sense, as various modifications can be made to the above method without departing from the scope of the invention.

[0138] The following examples are intended to be non-limiting and illustrative only. The amounts of ingredients in the compositions / formulations described below are expressed as weight percent based on the total weight of the composition. Example 1 (Cosmetic composition) TIFF0007728457000002.tif152170

[0139] Example 2 (Stability test) Tests were conducted to determine whether ceramide NPs were solubilized below 95°C. To determine ceramide NP solubility, components (a), (c), (d), (e), (f), and (g) were combined and heated to 95°C with constant stirring. If the mixture became clear below 95°C, it was initially solubilized. The mixture was then added to a hot aqueous phase (85-90°C) (component (b)), homogenized, stirred, and allowed to cool. Solubility was monitored by microscopic and macroscopic changes (e.g., gritty texture). Inventive compositions A and B solubilized ceramide NPs and are therefore designated "Y" (yes) for solubility in the table of Example 1. Comparative compositions C-1 through C-4 did not solubilize ceramide NPs and are therefore designated "N" (no) for solubility in the table of Example 1. Comparative compositions C-1 to C-4 did not solubilize ceramide NPs, and therefore these compositions were not subjected to further stability testing.

[0140] The inventive compositions A and B of Example 1 were subjected to physical stability testing, visually evaluating for phase separation and microscopically evaluating for particulate formation. The compositions were analyzed at the time of initial preparation (T0). After a 10-day freeze-thaw test, the compositions were analyzed again. For the freeze-thaw test, the compositions were placed in a stability chamber and subjected to temperature fluctuations at 12-hour intervals. For 12 hours, the compositions were held at -20°C. For the next 12 hours, the compositions were held at 25°C. This cycle was repeated 10 times (10 days). Separately, the compositions of Example 1 were evaluated after 4 weeks (1 month) of storage at 4°C, 25°C, 37°C, and 45°C, and again after 8 weeks (2 months) at 4°C, 25°C, 37°C, and 45°C, and visually evaluating for phase separation and microscopically evaluating for particulate formation.

[0141] The inventive composition was deemed stable ("Y") (yes) because it did not visually phase separate or form particulates.

[0142] The foregoing description illustrates and describes the present invention. While the present disclosure shows and describes only the preferred embodiments, it should be understood that the present invention can be used in various other combinations, modifications, and environments, and can be changed or modified within the scope of the inventive concept expressed herein, commensurate with the above teachings and / or skill or knowledge of the relevant art. The embodiments described herein above further explain the best mode known by the applicant and are intended to enable others skilled in the art to utilize the present disclosure in such or other embodiments, and with various modifications dictated by their particular application or use. Therefore, the description is not intended to limit the invention to the form disclosed herein.

[0143] definition As used herein, the terms "comprising," "having," and "including" (or "comprise," "have," and "include") are used in their open, non-limiting sense. The phrase "consisting essentially of" limits the scope of a claim to certain materials or steps, and those that do not materially affect the basic and novel characteristics of the claimed invention.

[0144] The terms "a," "an," and "the" are understood to encompass plural as well as singular.

[0145] Thus, the term "a mixture thereof" also relates to "mixtures thereof." Throughout this disclosure, when the term "mixture thereof" is used, it follows the list of elements shown in the following example, where letters A through F represent elements: "one or more elements selected from the group consisting of A, B, C, D, E, F, or mixtures thereof." The term "mixture thereof" does not require that the mixture contain all of A, B, C, D, E, and F (although it may contain all of A, B, C, D, E, and F). Rather, it indicates that a mixture of any two or more of A, B, C, D, E, and F may be included. In other words, it is equivalent to the phrase "one or more elements selected from A, B, C, D, E, F, and mixtures of any two or more of A, B, C, D, E, and F."

[0146] Similarly, the term "a salt thereof" also relates to "salts thereof." Thus, when the present disclosure refers to "an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, or a mixture thereof," it indicates that one or more of A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

[0147] Salts referred to throughout this disclosure may include salts with counterions such as alkali metal, alkaline earth metal, or ammonium counterions. However, this list of counterions is not limiting. Suitable counterions for the components described herein are known in the art.

[0148] The phrase "one or more" means "at least one" and thus includes individual components and mixtures / combinations.

[0149] The term "plurality" means "more than one" or "two or more."

[0150] An "alkyl radical" is a linear or branched saturated hydrocarbon-based group, in particular C1-C8, more particularly C1-C6, preferably C1-C4, such as methyl, ethyl, isopropyl and tert-butyl.

[0151] An "alkoxy radical" is alkyl-oxy, wherein alkyl is as previously described herein.

[0152] An "alkenyl radical" is a straight-chain or branched unsaturated hydrocarbon-based group, in particular C2-C8, more particularly C2-C6, preferably C2-C4, such as ethylenyl, propylenyl.

[0153] An "alkylene radical" is a straight-chain or branched divalent saturated C1-C8, especially C1-C6, preferably C1-C4 hydrocarbon-based group such as methylene, ethylene or propylene.

[0154] Some of the various categories of ingredients identified for cosmetic compositions may overlap. While overlap may exist, if a composition / product contains two overlapping ingredients (or three or more overlapping ingredients), the overlapping ingredients do not represent more than one ingredient. As an example, a fatty acid may be considered both a "non-triglyceride and non-aromatic fatty emollient" and a "surfactant / emulsifier." If a particular composition / product contains both a non-triglyceride and non-aromatic fatty emollient and a surfactant / emulsifier, a single type of fatty acid may function only as a non-triglyceride and non-aromatic fatty emollient or a surfactant / emulsifier (a single fatty acid does not function as both a non-triglyceride and non-aromatic fatty emollient and a surfactant / emulsifier).

[0155] All percentages, parts and ratios herein are based on the total weight of the compositions of the present invention unless otherwise indicated.

[0156] All ranges and values ​​disclosed herein are inclusive and combinable. For example, any value or point described herein that falls within a range described herein can serve as a minimum or maximum value for deriving subranges, etc. Furthermore, all ranges provided are intended to include all specific ranges within the given range and combinations of subranges between the given ranges. Thus, a range of 1 to 5 specifically includes points 1, 2, 3, 4, and 5, as well as subranges such as 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc., and points 1, 2, 3, 4, and 5 include ranges and subranges such as 1 to 5, 2 to 5, 3 to 5, 2 to 3, 2 to 4, 1 to 4, etc.

[0157] Other than in the examples, or where otherwise indicated, all numbers expressing quantities of ingredients and / or reaction conditions may be modified by the term "about," whether or not explicitly stated.

[0158] Furthermore, all numbers, whether modified by the term "about," are intended to represent the exact value as an additional embodiment. For example, "the amount of about 1%" can be modified to refer to exactly 1%. As a further example, "the amount of 1%" can be modified to refer to "about 1%." Unless otherwise indicated, the term "about" is understood to encompass a range of + / - 10% from the stated number. However, in some embodiments, the term may be defined to encompass a narrower range from the stated number, for example, + / - 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, and 10%.

[0159] The terms "surfactant" and "emulsifier" include salts of surfactants and emulsifiers, even if not explicitly stated otherwise. In other words, whenever this disclosure refers to a surfactant or emulsifier, it is intended to encompass salts to the extent such salts exist, for example, by using phrases such as "a salt thereof" or "salts thereof," even if the specification does not specifically refer to salts (or does not refer to salts in all instances throughout this disclosure). Sodium and potassium are common cations that form salts with surfactants and emulsifiers. However, additional cations, such as ammonium ions, or alkanolammonium ions, such as monoethanolammonium or triethanolammonium ions, may also form salts of surfactants.

[0160] As used herein, the terms "substantially free" or "essentially free" mean that a particular material may be present in such small amounts that it does not substantially affect the basic and novel characteristics of the claimed invention. For example, a particular material may be added to a composition in an amount of less than 2% by weight, based on the total weight of the composition (provided that an amount less than 2% by weight does not substantially affect the basic and novel characteristics of the claimed invention). Similarly, a composition that is "substantially free" or "essentially free" of a described material may contain less than 1.5% by weight, less than 1% by weight, less than 0.5% by weight, less than 0.1% by weight, less than 0.05% by weight, or less than 0.01% by weight of the specified material, or may not contain the specified material. As used herein, the terms "substantially free" or "essentially free" may also mean that a particular material is not added to a composition but may still be present in ingredients included in the composition.

[0161] Furthermore, any component affirmatively recited in this disclosure may be negatively excluded from the claims; for example, the claimed composition may be "free of," "essentially free of" (or "substantially free of") one or more components affirmatively recited in this disclosure. As an example, while silicone may optionally be included in the cosmetic composition, preferably the composition is free of or essentially free of silicone. Silicone is a synthetic polymer composed of repeating units of siloxane, elemental silicon and oxygen, combined with other elements, most often carbon and hydrogen. Therefore, silicone is also referred to as polysiloxane. In some examples, the cosmetic composition of this example may be free of or essentially free of dimethicone, amodimethicone, dimethiconol, cyclic siloxane, siloxane, etc.

[0162] All publications and patent applications cited herein are incorporated by reference for all purposes as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. In the event of a conflict between the present disclosure and any publication or patent application incorporated by reference herein, the present disclosure shall control.

Claims

1. 1. A cosmetic composition comprising: (a) ceramide NP, (b) water; (c) one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) one or more secondary emulsifiers selected from glyceryl esters having an HLB (hydrophilic-lipophilic balance) of about 3 to about 6; (e) one or more third emulsifiers selected from ethoxylated fatty acids; (f) one or more fatty alcohols, and (g) one or more non-triglyceride and non-aromatic fatty compounds Including, The composition is an oil-in-water emulsion, all percentages by weight, and the composition comprises: a weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs of about 1.5:1 to about 8:1 ((c):(a)); a weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP of about 0.8:1 to about 4:1 ((d):(a)); a weight ratio of one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NP of about 0.7:1 to about 4:1 ((e):(a)); a weight ratio of one or more fatty alcohols to ceramide NP of about 0.7:1 to about 4:1 ((f):(a)); and a weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NP of about 4:1 to about 20:1 ((g):(a)); comprising one or more weight ratios selected from Cosmetic composition.

2. (a) about 0.1 to about 5% by weight of ceramide NP; (b) water; (c) from about 0.5 to about 5% by weight of one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) from about 0.5 to about 5% by weight of one or more second emulsifiers selected from glyceryl esters having an HLB of from about 3 to about 6; (e) from about 0.5 to about 5 wt. % of one or more third emulsifiers selected from ethoxylated fatty acids; (f) from about 0.2 to about 5% by weight of one or more fatty alcohols; and (g) from about 4 to about 20% by weight of one or more non-triglyceride and non-aromatic fatty compounds Including, the composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the composition; The cosmetic composition of claim 1.

3. 3. The composition of claim 1, wherein the polyglycerol emulsifier is selected from polyglyceryl 10-stearate, polyglyceryl-3-caprate, polyglyceryl-3-diisostearate, polyglyceryl-3 methylglucose distearate, and mixtures thereof.

4. 3. The composition of claim 1, wherein the glyceryl ester having an HLB of about 3 to about 6 is selected from bis-diglyceryl polyacyladipate-2, glyceryl behenate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl palmitate lactate, glyceryl sesquioleate, glyceryl stearate, citrate, glyceryl dioleate, glyceryl distearate, glyceryl laurate, or mixtures thereof. In at least one example, the glyceryl ester comprises glyceryl stearate, bis-diglyceryl polyacyladipate, glyceryl ricinoleate, or a mixture thereof.

5. 3. The composition of claim 1 or 2, wherein the ethoxylated fatty acid has in the range of 40 to 100 propylene oxide groups and a fatty chain of 12 to 24 carbon atoms.

6. 3. The composition of claim 1, wherein the fatty alcohol has 12 to 24 carbon atoms.

7. 3. The composition of claim 1, wherein the fatty alcohol is selected from cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, myristic or myristyl alcohol, arachidyl alcohol, lignoceryl alcohol, or mixtures thereof.

8. A composition described in claim 1 or 2, wherein the one or more non-triglyceride and non-aromatic fatty compounds are selected from fatty esters (isopropyl myristate, sorbitan isostearate), acyl sarcosinates (isopropyl lauroyl sarcosinate), and mixtures thereof, polyolefins (petrolatum), waxes, squalane, squalene, hydrogenated polyisobutene, hydrogenated polydecene, polybutene, mineral oil, pentahydrosqualene, vegetable oil and / or plant oil, hydrocarbon oil, and mixtures thereof.

9. The composition described in claim 8, wherein one or more non-triglyceride and non-aromatic fatty compounds are selected from fatty esters (isopropyl myristate, sorbitan isostearate), acyl sarcosinates (isopropyl lauroyl sarcosinate), and mixtures thereof.

10. 3. The composition of claim 1 or 2, further comprising (h) hydroxypropyltetrahydropyrantriol.

11. The composition of claim 10, wherein the amount of hydroxypropyltetrahydropyrantriol is from about 10 to about 40% by weight, based on the total weight of the composition.

12. 3. The composition of claim 1 or 2, further comprising (i) one or more thickening polymers, preferably from about 0.1 to about 5 wt. % of one or more thickening polymers.

13. The one or more thickening polymers may be selected from the group consisting of polyacrylates, polymethacrylates, polyethyl acrylates, and polyacrylamides, acrylic acid / acrylonitrile copolymers, acrylates / steareth-20 itaconate copolymers, acrylates / ceteth-20 itaconate copolymers, acrylates / aminoacrylates / C10-30 alkyl PEG-20 itaconate copolymers, acrylates / aminoacrylate copolymers, acrylates / steareth-20 methacrylate copolymers, acrylates / beheneth-25 methacrylate copolymers, acrylates / steareth-20 methacrylate crosspolymers, acrylates / beheneth-25 methacrylate / HEMA crosspolymers, acrylates / vinyl neodecanoate crosspolymers, acrylates / vinyl isodecanoate crosspolymers, acrylates / palmeth-25 acrylate copolymers, acrylic acid / acrylamidomethylpropanesulfonic acid copolymers, and acrylates / C10-C30 alkyl Acrylate crosspolymers, carbomers, hydrophobically modified polypolyacrylates; hydrophobically modified polyacrylic acids, hydrophobically modified polyacrylamides; hydrophobically modified polyethers, where these materials may have a hydrophobicity selected from cetyl, stearyl, oleayl, and combinations thereof, acrylamide / ammonium acrylate copolymer; acrylamide / sodium acryloyldimethyl taurate copolymer / isohexadecane / polysorbate 80, ammonium acryloyldimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, acrylates copolymer, acrylates crosspolymer-4, acrylates crosspolymer-3, acrylates / beheneth-25 methacrylate copolymer, acrylates / C10-C30 alkyl acrylate crosspolymer, acrylates / steareth-20 itaconate copolymer, ammonium polyacrylate / isohexadecane / PEG-40 castor oil;The composition of claim 11, wherein the surfactant is selected from sodium carbomer, cross-linked polyvinylpyrrolidone (PVP), polyacrylamide / C13-14 isoparaffin / laureth-7, polyacrylate 13 / polyisobutene / polysorbate 20, polyacrylate crosspolymer-6, polyamide-3, polyquaternium-37, acrylamide / sodium acryloyldimethyltaurate / acrylic acid copolymer, sodium acrylate / acryloyldimethyltaurate, sodium polyacrylate, and mixtures thereof, preferably selected from polyacrylates (e.g., sodium polyacrylate), hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, ammonium acryloyldimethyltaurate / VP copolymer, acrylamide / sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer-6, polyacrylamide, acrylate c10-30 alkyl acrylate crosspolymer, and mixtures thereof.

14. 3. The composition of claim 1 or 2, further comprising (j) one or more water-soluble solvents.

15. The composition of claim 14, comprising from about 1 to about 20% by weight of one or more water-soluble solvents.

16. The one or more water-soluble solvents may be glycerin, C ２ -C ６ 15. The composition of claim 14, wherein the alcohol is selected from monoalcohols, polyols (polyhydric alcohols), glycols, and mixtures thereof.

17. 3. The composition of claim 1, having a pH of about 5 to about 7.

18. A viscosity of about 20,000 to about 80,000 Pa.s at 25°C, and a viscosity of about 1 s at 25°C －１ 3. The composition of claim 1 or 2, having a shear rate of

19. 1. A cosmetic composition comprising: (a) about 0.5 to about 5 wt. % ceramide NP; (b) about 50 to about 80% by weight water; (c) from about 0.1 to about 5% by weight of one or more first emulsifiers selected from polyglyceryl 10-stearate, polyglyceryl-3-caprate, polyglyceryl-3-diisostearate, polyglyceryl-3 methylglucose distearate, and mixtures thereof; (d) from about 0.1 to about 5% by weight of bis-diglyceryl polyacyladipate-2, glyceryl behenate, glyceryl caprate, glyceryl cocoate, glyceryl erucate, glyceryl hydroxystearate, glyceryl isostearate, glyceryl lanolate, glyceryl laurate, glyceryl linoleate, glyceryl myristate, glyceryl oleate, glyceryl palmitate lactate, glyceryl sesquioleate, glyceryl stearate one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 10 selected from glyceryl stearate citrate, glyceryl stearate lactate, glyceryl dioleate, glyceryl distearate, glyceryl laurate, or mixtures thereof, in at least one example the glyceryl esters include glyceryl stearate, bis-diglyceryl polyacyladipate, glyceryl ricinoleate, or mixtures thereof; (e) from about 0.1 to about 5% by weight of one or more third emulsifiers selected from ethoxylated fatty acids having propylene oxide groups ranging from 40 to 100 and fatty chains of 8 to 24 carbon atoms; (f) from about 0.2 to about 5% by weight of one or more fatty alcohols having 8 to 24 carbon atoms; (g) from about 1 to about 10% by weight of one or more non-triglyceride and non-aromatic fatty compounds selected from fatty esters, acyl sarcosinates, or mixtures thereof; and (h) about 10 to about 20% by weight of hydroxypropyltetrahydropyrantriol; (i) optionally, one or more thickening polymers; (j) about 0.1 to about 10% by weight of glycerin, C ２ -C ６ One or more water-soluble solvents selected from monoalcohols, polyols (polyhydric alcohols), glycols, and mixtures thereof Including, the composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the composition; Cosmetic composition.

20. The ratio of: a weight ratio of one or more first emulsifiers selected from polyglycerol-based emulsifiers to ceramide NPs of about 1.5:1 to about 8:1 ((c):(a)); a weight ratio of one or more second emulsifiers selected from glyceryl esters having an HLB of about 3 to about 6 to ceramide NP of about 0.8:1 to about 4:1 ((d):(a)); a weight ratio of one or more third emulsifiers selected from ethoxylated fatty acids to ceramide NP of about 0.7:1 to about 4:1 ((e):(a)); a weight ratio of one or more fatty alcohols to ceramide NP of about 0.7:1 to about 4:1 ((f):(a)); and a weight ratio of one or more non-triglyceride and non-aromatic fatty compounds to ceramide NP of about 4:1 to about 20:1 ((g):(a)); 20. The composition of claim 19, comprising:

21. 1. A cosmetic composition comprising: (a) about 0.1 to about 5% by weight of ceramide NP; (b) water; (c) from about 0.5 to about 5% by weight of one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) from about 0.5 to about 5% by weight of one or more second emulsifiers selected from glyceryl esters having an HLB of from about 3 to about 6; (e) from about 0.1 to about 5 wt. % of one or more third emulsifiers selected from ethoxylated fatty acids; (f) from about 0.2 to about 5% by weight of one or more fatty alcohols; and (g) from about 0.1 to about 15% by weight of one or more non-triglyceride and non-aromatic fatty compounds Including, the composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the composition; Cosmetic composition.

22. 22. A method for stabilizing a cosmetic composition according to any one of claims 1, 2, 19 to 21, comprising about 0.1 to about 5% by weight of ceramide NP, comprising: (a) about 0.1 to about 5% by weight of ceramide NP; (b) water; (c) from about 0.5 to about 5% by weight of one or more first emulsifiers selected from polyglycerol-based emulsifiers; (d) from about 0.5 to about 5% by weight of one or more second emulsifiers selected from glyceryl esters having an HLB of from about 3 to about 6; (e) from about 0.1 to about 5 wt. % of one or more third emulsifiers selected from ethoxylated fatty acids; (f) from about 0.2 to about 5% by weight of one or more fatty alcohols; and (g) from about 0.1 to about 15% by weight of one or more non-triglyceride and non-aromatic fatty compounds [0033] the composition is an oil-in-water emulsion and all weight percentages are based on the total weight of the composition; method.

23. 21. A method of treating skin comprising applying to the skin a cosmetic composition according to any one of claims 1, 2, 19 and 20.

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