Mite repellent composition and mite repellent product

Abstract

To provide a mite repellent composition having an excellent mite repellent effect against house dust mites even after a long time has elapsed and also having excellent safety for humans and animals.SOLUTION: A mite repellent composition contains: (a) 1,8-cineol and / or 1,4-cineol; and (b) a perfume component, wherein the perfume component includes one or more kinds of perfume compounds having a logP value of 2.0 to 5.5. A blending ratio (a / b) of the component (a) to the perfume compound contained in component (b) is set to 5 to 100 on a mass basis. The perfume compound contained in the component (b) is at least one selected from the group consisting of ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene, and amyl salicylate.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a mite repellent composition and a mite repellent product for repelling house dust mites. [Background technology]

[0002] In recent years, changes in living environments have led to an increasing number of cases of large-scale indoor infestations of house dust mites, such as flour mites, house dust mites, dust mites, and chigger mites. House dust mites not only cause discomfort to people, but also cause problems such as allergic asthma and skin rashes. It has also become clear that even the carcasses of house dust mites, which cause allergic asthma, can cause allergies. Therefore, indoor miticides have been developed for treating bedding such as pillows, futons, and cushions. However, since indoor miticides often come into direct contact with the skin, a higher level of safety is required.

[0003] Against this background, technologies have been sought that do not kill house dust mites but rather keep them away from people and patients, and several proposals have been made to date. For example, Patent Document 1 discloses plant essential oils such as vetiver oil, patchouli oil, and clove oil as active ingredients in indoor mite control agents. Furthermore, Patent Document 2 discloses citronellal, linalool, citral, and the like. These conventional technologies claim to be natural products and to be safe, but their repellent effects against house dust mites are not necessarily satisfactory.

[0004] Meanwhile, cineole has attracted attention as a pest repellent ingredient. Patent Document 3 discloses a house dust mite repellent containing 1,8-cineole as an active ingredient. However, because 1,8-cineole and 1,4-cineole are relatively volatile, it has been considered difficult to maintain the mite repellent effect for a long period of time, more than two to three months. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 6-16515 [Patent Document 2] Japanese Patent Application Laid-Open No. 2001-294505 [Patent Document 3] Japanese Patent Application Laid-Open No. 2001-31508 Summary of the Invention [Problem to be solved by the invention]

[0006] The present invention has been made in consideration of the above problems, and aims to provide a mite repellent composition and a mite repellent product that have excellent mite repellent effect against house dust mites even after a long period of time has passed, and that are also safe for humans and animals. [Means for solving the problem]

[0007] The characteristic features of the mite repellent composition of the present invention for solving the above problems are as follows: (a) 1,8-cineole and / or 1,4-cineole, (b) a fragrance ingredient; and A mite repellent composition comprising: The fragrance component contains one or more fragrance compounds having a logP value of 2.0 to 5.5.

[0008] The mite repellent composition of this configuration is formulated to contain (b) a fragrance component in addition to (a) 1,8-cineole and / or 1,4-cineole. The fragrance component contains one or more fragrance compounds with a logP value of 2.0 to 5.5. Therefore, the excellent mite repellent effect of the relatively highly volatile (a) 1,8-cineole and / or 1,4-cineole against house dust mites can be maintained for a long period of time by the fragrance compound with a logP value of 2.0 to 5.5 contained in component (b). Furthermore, components (a) and (b) are highly safe for humans and animals, allowing the mite repellent composition to achieve high safety.

[0009] In the mite repellent composition of the present invention, The blending ratio (a / b) of the component (a) to the flavor compound contained in the component (b) is preferably set to 5 to 100 on a mass basis.

[0010] According to the mite repellent composition of this configuration, the blending ratio (a / b) of the fragrance compounds contained in component (a) and component (b) is set within an appropriate range, thereby achieving both excellent mite repellent effect against house dust mites and high safety for humans and animals.

[0011] In the mite repellent composition of the present invention, The fragrance compound contained in component (b) is preferably at least one selected from the group consisting of ethyl cinnamate, allyl caproate, 3-methyl-5-phenyl-1-pentanol, citronellol, δ-dodecalactone, β-ionone, benzyl benzoate, linalyl acetate, geranyl acetate, tricyclodecenyl propionate, benzyl salicylate, limonene, and amyl salicylate.

[0012] According to the mite repellent composition of this configuration, the fragrance compound contained in component (b) is appropriately selected, so that the excellent mite repellent effect of component (a) can be stably maintained for a long period of time.

[0013] The characteristic configuration of the mite repellent product according to the present invention to solve the above problems is as follows: A solid carrier containing any one of the above mite repellent compositions; a breathable packaging material for storing or packaging the solid carrier; The purpose is to include

[0014] According to the mite repellent product of this configuration, a solid carrier containing the mite repellent composition of the present invention is stored or packaged in a breathable packaging material, making it possible to realize a mite repellent product that is low cost, has excellent mite repellent effect against indoor dust mites, and is highly safe for humans and animals.

[0015] In the mite repellent product of the present invention, The solid carrier is preferably in the form of particles having an average particle size of 1 to 8 mm.

[0016] In the mite repellent product of this configuration, the average particle size of the solid carrier is appropriately adjusted, so that the mite repellent composition can be volatilized stably from the solid carrier for a long period of time, and the mite repellent product can be easy to use and highly practical.

[0017] In the mite repellent product of the present invention, The solid carrier preferably contains 20 to 400 mg of the component (a) per 1 g.

[0018] According to the mite repellent product of this configuration, the solid carrier contains an appropriate amount of component (a), and therefore, it is possible to exhibit excellent mite repellent effects against house dust mites while maintaining a high level of safety. DETAILED DESCRIPTION OF THE INVENTION

[0019] The mite repellent composition and mite repellent product of the present invention will be described below, but it is not intended that the present invention be limited to the configurations and examples described below.

[0020] <Mite repellent composition> The mite repellent composition of the present invention contains 1,8-cineole and / or 1,4-cineole (component (a)) and a fragrance component (component (b)). Here, component (b) contains at least one fragrance compound having a logP value of 2.0 to 5.5, as described below.

[0021] [Component (a)] The 1,8-cineole and / or 1,4-cineole used as component (a) act as mite repellent ingredients. 1,8-cineole is a substance found in large amounts in eucalyptus essential oil, and 1,4-cineole is a substance found in large amounts in Limonium littoralis essential oil, both of which have a refreshing scent. 1,8-cineole and 1,4-cineole are generally known as antitussives and antiviral agents, and are considered to be low-toxicity, non-irritating, and non-sensitizing to humans. Furthermore, as described in the Background Art section, 1,8-cineole and 1,4-cineole are relatively volatile, and therefore, when used as mite repellent ingredients, it has been considered difficult to maintain the mite repellent effect for a long period of time (more than 2-3 months).

[0022] However, the present inventors have conducted extensive research into adjusting the volatility of mite repellent compositions containing 1,8-cineole and / or 1,4-cineole as component (a), and have found that by incorporating a fragrance compound having a logP value of 2.0 to 5.5 contained in component (b) described below, the volatility of 1,8-cineole and / or 1,4-cineole can be effectively adjusted, and excellent mite repellent effect against house dust mites can be achieved even over a long period of time. Furthermore, the mite repellent composition of the present invention is highly safe for humans and animals, making it extremely practical and useful.

[0023] The mite repellent composition of the present invention is prepared by adding various ingredients to component (a) and component (b), which will be described later, and can be applied to various types of mite repellent products. The amount of component (a) relative to the total weight of the mite repellent product varies depending on the type of mite repellent product, but is preferably set at approximately 0.02 to 1.0 g per mite repellent product. For pillows and cushions, applying one product at a time is convenient. For large bedding such as futons and mattresses, the number of applications can be increased as needed. In the present invention, component (a) may be 1,8-cineole or 1,4-cineole alone, or eucalyptus essential oil or lily of the valley essential oil, which contain large amounts of these, may be used as the active ingredient. For example, eucalyptus essential oil containing 70% or more by mass of 1,8-cineole is widely available commercially. Although it is possible to use a mixture of 1,8-cineole and 1,4-cineole as component (a), it is preferable to use 1,8-cineole from the viewpoint of the mite repellent effect.

[0024] The amount of component (a) in the mite repellent composition is preferably 10 to 90 mass %, more preferably 20 to 85 mass %.

[0025] [(b) Component] The fragrance component used as component (b) acts as a volatility-adjusting component. Component (b) contains one or more fragrance compounds with a logP value of 2.0 to 5.5. That is, the fragrance component may contain not only one fragrance compound but also two or more fragrance compounds. When the fragrance component contains one fragrance compound, the logP value of that fragrance compound is 2.0 to 5.5. When the fragrance component contains two or more fragrance compounds, it is preferable that each fragrance compound has a logP value of 2.0 to 5.5, but it is sufficient that at least one fragrance compound has a logP value of 2.0 to 5.5. By incorporating component (b) containing a fragrance compound with a logP value of 2.0 to 5.5 into the mite repellent composition, the volatility of component (a) can be effectively adjusted, thereby providing excellent mite repellency against house dust mites even after a long period of time has passed. The logP value of the fragrance compounds contained in component (b) is preferably in the range of 3.0 to 5.0. Here, the logP value is a coefficient that indicates the affinity of an organic compound for water and 1-octanol. The 1-octanol / water partition coefficient P is the partition equilibrium when a trace amount of a compound is dissolved as a solute in a two-phase solvent, 1-octanol and water, and is the ratio of the equilibrium concentrations of the compound in each solvent, and is generally expressed in the form of their logarithm, logP, to the base 10. Note that the logP values ​​described in this specification are not actual measured values, but calculated values ​​calculated using a dedicated application (Advanced Chemistry Development (ACD / Labs) Software V11.02).

[0026] The fragrance compound contained in component (b) and having a logP value of 2.0 to 5.5 is not particularly limited, but a monocyclic or open-chain fragrance compound can be used. Examples of fragrance compounds having a logP value of 2.0 to 5.5 include the following. The number in brackets [ ] after the fragrance compound indicates the logP value.

[0027] Alcohol-based fragrance compounds such as eugenol [2.4], α-terpineol [2.7], linalool [2.8], geraniol [2.9], 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [3.2], phenylhexanol [3.4], and tetrahydrolinalool [3.5], as well as methyl cinnamate [2.5], γ-decalactone [2.5], and dihydrolinalool. Methyl drojasmonate [2.6], ethyl benzoate [2.6], cinnamyl acetate [2.6], hexyl acetate [2.8], ethyl cinnamate [3.0], γ-undecalactone [3.0], δ-undecalactone [3.0], tricyclodecenyl acetate [3.1], allyl caproate [3.1], benzyl phenylacetate [3.5], γ-dodecalactone [3.5], δ-dodecalactone Calactone [3.5], benzyl cinnamate [3.8], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], 2-phenylethyl phenylacetate [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], cyclohexyl salicylate [4.5], amyl salicylate [4.6], hexyl salicylate [5.1] Examples of fragrance compounds include ester-based fragrance compounds such as pentalide [5.2], ketone-based fragrance compounds such as β-damascone [3.3], α-damascone [3.4], β-ionone [3.6], and α-ionone [3.7], aldehyde-based fragrance compounds such as amyl cinnamic aldehyde [4.4] and hexyl cinnamic aldehyde [4.9], and hydrocarbon-based fragrance compounds such as limonene [4.6].Among these, the following fragrance compounds are monocyclic or chain-type fragrance compounds with logP values ​​of 3.0 or more and 5.0 or less: 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [3.2], phenylhexanol [3.4], tetrahydrolinalool [3.5], ethyl cinnamate [3.0], γ-undecalactone [3.0], δ-undecalactone [3.0], tricyclodecane acetate, etc. Cenyl [3.1], allyl caproate [3.1], benzyl phenylacetate [3.5], γ-dodecalactone [3.5], δ-dodecalactone [3.5], benzyl cinnamate [3.8], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], 2-phenylethyl phenylacetate [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], salicylate Preferably, the compound is at least one selected from the group consisting of cyclohexyl licylate [4.5], amyl salicylate [4.6], β-damascone [3.3], α-damascone [3.4], β-ionone [3.6], α-ionone [3.7], amyl cinnamic aldehyde [4.4], hexyl cinnamic aldehyde [4.9] and limonene [4.6], and more preferably, ethyl cinnamate [3.0], arylic acid caproate Preferred fragrance compounds are benzoyl [3.1], 3-methyl-5-phenyl-1-pentanol [3.2], citronellol [3.2], δ-dodecalactone [3.5], β-ionone [3.6], benzyl benzoate [3.8], linalyl acetate [3.9], geranyl acetate [3.9], tricyclodecenyl propionate [4.0], benzyl salicylate [4.2], limonene [4.6], and amyl salicylate [4.6]. These fragrance compounds may be used alone or in combination.

[0028] The logP values ​​of 1,8-cineole and / or 1,4-cineole used as component (a) are 1,8-cineole [2.8] and 1,4-cineole [2.4]. The logP values ​​of these components (a) and the logP values ​​of the fragrance compounds contained in component (b) partially overlap or are close to each other, indicating that components (a) and (b) are compatible at the molecular level. This is presumably why component (b), including the fragrance compounds, effectively adjusts the volatility of component (a), resulting in the excellent mite repellent effect against house dust mites, such as acarid mites, house dust mites, and chigger mites, even after a long period of time.

[0029] The blending amount of the fragrance compound contained in component (b) in the mite repellent composition is preferably 0.01 to 20 mass %, more preferably 0.1 to 10 mass %.

[0030] The blending ratio (a / b) of the fragrance compounds contained in component (a) and component (b) is preferably set to 5 to 100 by mass, and more preferably 5 to 80. When the blending ratio (a / b) is within the above range, the volatility of (a) 1,8-cineole and / or 1,4-cineole can be effectively adjusted, ensuring high safety while providing excellent mite repellent effects against house dust mites even after a long period of time has passed. Therefore, it is possible to achieve both excellent mite repellent effects against house dust mites and high safety for humans and animals.

[0031] [Other ingredients] In addition to the above-mentioned components (a) and (b), the mite repellent composition of the present invention may contain various solvents, such as alcohol solvents such as water, ethanol, and isopropanol, glycol solvents such as 1,3-butylene glycol, propylene glycol, and dipropylene glycol, glycol ether solvents such as diethylene glycol monobutyl ether and propylene glycol monomethyl ether, and aliphatic hydrocarbon solvents such as normal paraffin and isoparaffin, as well as surfactants (solubilizers).The mite repellent composition of the present invention can also be prepared without adding other components, such as solvents, in addition to the above-mentioned components (a) and (b).

[0032] Examples of surfactants include nonionic surfactants such as polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alkyl ethers (polyoxyethylene lauryl ether, polyoxyethylene oleyl ether), polyoxyethylene higher fatty acid esters, polyoxyethylene polyoxypropylene alkyl ethers, and higher alkylamine oxide surfactants such as laurylamine oxide, stearylamine oxide, and lauric acid amidopropyldimethylamine oxide. The surfactants may be used alone or in combination of two or more.

[0033] The mite repellent composition of the present invention may also contain antibacterial components, antifungal components, deodorizing components, fragrance components, insecticidal components, repellent components, stabilizers, pH adjusters, colorants, gelling agents, etc. Furthermore, for example, leaf alcohol (cis-3-hexen-1-ol) and leaf aldehyde, known as the "green scent," may be added, which can impart a relaxing effect and promote sound sleep.

[0034] Examples of antibacterial components include phenolic antibacterial components such as isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,5-dimethylphenol, orthophenylphenol, o-cresol, m-cresol, and p-cresol; benzalkonium salts such as benzalkonium chloride, benzalkonium methosulfate, and benzalkonium organic acid salts; benzethonium salts such as benzethonium chloride, benzethonium methosulfate, and benzethonium organic acid salts; cetylpyridinium salts such as cetylpyridinium chloride, cetylpyridinium methosulfate, and cetylpyridinium organic acid salts; didecyldimethylammonium salts such as didecyldimethylammonium chloride and didecyldimethylammonium methosulfate; dilauryldimethylammonium salts such as dilauryldimethylammonium chloride and dilauryldimethylammonium methosulfate; distearyldimethylammonium chloride; Distearyldimethylammonium salts such as ammonium methosulfate, and cationic surfactant-based antibacterial ingredients such as 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane dibromide, 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane dichloride, 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane dimethosulfate and other 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane salts, biguanide-based antibacterial ingredients, tebuconazole, enilconazole Azole-based antibacterial ingredients such as azole, fruit seed extract-based antibacterial ingredients such as grapefruit seed extract, persimmon seed extract, grape seed extract, etc., glycerin mono fatty acid ester-based antibacterial ingredients such as monolaurin, monocaprin, monocaprylin, etc., chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride, chlorhexidine-based antibacterial ingredients such as chlorhexidine, octadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, dodecyldimethyl(3-triethoxysilylpropyl)ammonium chloride,Dodecyldiisopropyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldiethyl(3-triethoxysilylpropyl)ammonium Examples of antibacterial agents include silicon-based antibacterial agents such as ammonium chloride, hexadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, octadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, and octadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride; carboxylic acid-based antibacterial agents such as benzoic acid, salicylic acid, sorbic acid, ethylenediaminetetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, and polylysine, or salts thereof; dehydroacetic acid, chloramine, 3-iodo-2-propyl-N-butylcarbamate (IPBC), phenoxyethanol, and silver-based antibacterial agents such as silver zeolite; zinc pyrithione, thiamine lauryl sulfate, milt protein, and hydroxyalkylchitosan or salts thereof. The above antibacterial agents may be used alone or in combination.

[0035] Examples of antifungal ingredients include phenolic antifungal ingredients such as isopropylmethylphenol (IPMP), carvacrol, thymol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,5-dimethylphenol, orthophenylphenol, o-cresol, m-cresol, and p-cresol; benzalkonium salts such as benzalkonium chloride, benzalkonium methosulfate, and benzalkonium organic acid salts; benzethonium chloride; and benzethonium methosulfate. cetylpyridinium salts such as cetylpyridinium chloride, cetylpyridinium methosulfate, and cetylpyridinium organic acid salts; didecyldimethylammonium salts such as didecyldimethylammonium chloride and didecyldimethylammonium methosulfate; dilauryldimethylammonium salts such as dilauryldimethylammonium chloride and dilauryldimethylammonium methosulfate; distearyldimethylammonium chloride, distearyldimethylammonium Distearyldimethylammonium salts such as methylmethosulfate, and cationic surfactant antifungal ingredients such as 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane dibromide, 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane dichloride, 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane dimethosulfate and other 1,4-bis[3,3'-(1-decylpyridinium)methyloxy]butane salts, biguanide antifungal ingredients, tebuconazole, enilconazole antifungal ingredients such as azole antifungal ingredients such as benzoyl alcohol, fruit seed extract antifungal ingredients such as grapefruit seed extract, persimmon seed extract, grape seed extract, etc., glycerin mono fatty acid ester antifungal ingredients such as monolaurin, monocaprin, monocaprylin, etc., chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride, and chlorhexidine antifungal ingredients such as chlorhexidine, octadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, dodecyldimethyl(3-triethoxysilylpropyl)ammonium chloride,Dodecyldiisopropyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, tetradecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldiethyl(3-triethoxysilylpropyl)ammonium chloride, pentadecyldi-n-propyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldimethyl(3-triethoxysilylpropyl)ammonium chloride, hexadecyldiethyl(3-triethoxysilylpropyl)ammonium Examples of suitable antifungal agents include silicon-based antifungal agents such as benzoic acid, salicylic acid, sorbic acid, ethylenediaminetetraacetic acid (EDTA), glycine, alkyldiethylaminoglycine, and polylysine, as well as salts thereof; silver-based antifungal agents such as dehydroacetic acid, chloramine, 3-iodo-2-propyl-N-butylcarbamate (IPBC), phenoxyethanol, and silver zeolite; zinc pyrithione, thiamine lauryl sulfate, milt protein, hydroxyalkylchitosan or its salt; and antifungal fragrances. These antifungal agents may be used alone or in combination.

[0036] Examples of deodorizing components include plant-derived deodorizing components. Examples of plant-derived deodorizing components include plant extracts extracted from plants of the Poaceae, Theaceae, Ginkgoceae, Oleaceae, Moraceae, Rutaceae, Canthaceae, and Ebenaceae families. The above plant extracts may be used alone or as a mixture of two or more types, and representative examples include green tea extract and persimmon extract.

[0037] Examples of gelling agents include carrageenan, xanthan gum, gellan gum, gelatin, aluminum octoate, 12-hydroxystearic acid, etc. The above gelling agents may be used alone or as a mixture of two or more kinds.

[0038] <Tick repellent products> The mite repellent product of the present invention contains the mite repellent composition of the present invention described above and can be prepared in various forms, such as solid, liquid, or gel, depending on the situation of use and the needs of consumers. Among these, a product form in which the mite repellent composition is impregnated or retained on a solid carrier and then housed or packaged in a breathable material is preferred. Simply placing such a mite repellent product under or near a pillow, cushion, futon, mat, or the like effectively volatilizes the mite repellent component from the solid carrier, thereby achieving a mite repellent product that is low-cost yet has excellent mite repellent effect against house dust mites and is highly safe for humans and animals.

[0039] Examples of solid carriers include pulps such as cellulose pulp, linters, rayon, and other fibrous carriers, cellulose (regenerated cellulose) beads or foams, inorganic porous carriers such as silicates, silica, zeolites, and sublimable carriers such as trioxane and adamantane. Of these, pulps such as cellulose pulp, linters, rayon, and other fibrous carriers, and cellulose (regenerated cellulose) beads are preferred, with cellulose pulp being more preferred.

[0040] When the solid carrier is in the form of beads (granules), the average particle size is usually 1 to 8 mm, preferably 3 to 8 mm, and more preferably 4 to 7 mm. The apparent specific gravity of the solid carrier is usually about 0.10 to 0.35, and preferably 0.15 to 0.30. For example, by adding about 20 to 400 mg, preferably 30 to 300 mg, of the (a) 1,8-cineole and / or 1,4-cineole per gram of cellulose pulp and storing this in a breathable packaging material, a useful and highly practical mite repellent product of the present invention can be obtained.

[0041] Examples of breathable packaging materials include nonwoven bags, cotton bags, net cases, and perforated plastic containers. Among these, nonwoven bags are preferred for their ease of use. Examples of materials for nonwoven bags include polyester (PET), polyethylene (PE), polypropylene (PP), polyamide, polylactic acid, and rayon. Nonwoven bags may be made of a single fiber, or may be laminates or blends such as polyester laminated with paper or polypropylene / rayon. Among these, polyester, polyethylene, and polypropylene are preferred because they can partially adsorb (a) 1,8-cineole and / or 1,4-cineole, thereby secondarily adjusting the amount of volatilization. The shape and configuration of the nonwoven bag can also be determined appropriately. For example, both sides may be made of nonwoven fabric of the above material, or one side may be made of nonwoven fabric of the above material and the other side may be made of a plastic film with numerous small holes, which are then bonded together.

[0042] The mite repellent product of the present invention thus obtained can be applied to any location, including, but not limited to, carpets, tatami mats, pillows, cushions, futons, and mats. It is particularly suitable for use in bedding, such as pillows, cushions, futons, and mats. When placed under or near a pillow, cushion, futon, or mat, the mite repellent component volatilizes from the solid carrier through the breathable material, providing a practical repellent effect over a long period of one to six months against various pests, including house dust mites such as flour mites, house dust mites, dust mites, and chiggers, as well as weevils, dermestid beetles, booklice, silverfish, cockroaches, ants, mosquitoes, midges, midges, flies, moths, and burrowing moths. The mite repellent product of the present invention is particularly effective against house dust mites, such as flour mites, house dust mites, dust mites, and chiggers. [Example]

[0043] The present invention will be specifically described below with reference to examples.

[0044] Example 1 A mite repellent composition was prepared by directly mixing 400 mg of 1,8-cineole as component (a) and 8 mg of 3-methyl-5-phenyl-1-pentanol as component (b). The entire amount of this mite repellent composition was impregnated into approximately 8 g of cellulose pulp granules with an average particle size of 5.5 mm and an apparent specific gravity of 0.21. The cellulose pulp granules impregnated with the mite repellent composition were then placed in a nonwoven bag (9 x 12 cm) made of breathable polyethylene / polypropylene blend nonwoven fabric on both sides, to obtain the mite repellent product of Example 1.

[0045] [Examples 2 to 11, Comparative Examples 1 to 2, Reference Examples 1 to 3] A mite repellent composition containing components (a) and (b) in the formulation shown in Table 1 was prepared in accordance with Example 1, and various mite repellent products of Examples 2 to 11, Comparative Examples 1 and 2, and Reference Examples 1 to 3 were obtained using the same procedures as in Example 1.

[0046] [Table 1]

[0047] [Tick repellent efficacy test] Each of the mite repellent products of Examples 1 to 11, Comparative Examples 1 and 2, and Reference Examples 1 to 3 was wrapped in a wool blanket, a 4 kg weight was placed on top, and the product was left standing at room temperature for 2 months, after which each mite repellent product was collected.

[0048] Next, a medium containing approximately 100,000 test Dermatophagoides pteronyssinus mites was evenly spread in the center of a 50 cm square cotton cloth. Each of the above-mentioned mite repellent products after two months of standing was placed on a pillow and covered with a pillowcase. 1 g of the attractant medium was then spread on the surface, and the pillow was then placed in the center of the cotton cloth, which served as the treatment area. The same procedure was also carried out using a pillow without the mite repellent product, which served as the untreated area. After 24 hours, the number of mites that had invaded the pillowcase was counted, and the mite repellent efficacy (repellency rate) was calculated according to the following formula: Mite repellent efficacy (%) = (N0-N1) / N0 x 100 N0: Number of invaded mites in the untreated area N1: Number of invaded mites in the treated area

[0049] The results of the mite repellent efficacy test are shown in Table 2.

[0050] [Table 2]

[0051] It was found that the mite repellent products of Examples 1 to 11 all maintained excellent mite repellent efficacy of 80% or more even after two months. This is thought to be because component (b), which contains a fragrance compound with a logP value of 2.0 to 5.5, effectively controlled the volatilization of (a) 1,8-cineole and / or 1,4-cineole, which is why the mite repellent products of Examples 1 to 11 achieved excellent mite repellent efficacy even after a long period of time. Among these, the mite repellent products of Examples 1, 3 to 7, 10, and 11, which contained (a) 1,8-cineole and component (b), which contains a fragrance compound with a logP value of 3.0 to 5.0, all maintained mite repellent efficacy of 85% or more even after two months, and were found to be more excellent.

[0052] On the other hand, the mite repellent product of Reference Example 1, which contained cyclohexadecanolide (logP value: 5.7) with a logP value exceeding 5.5 as component (b), and the mite repellent product of Reference Example 2, which contained butyl acetate (logP value: 1.8) with a logP value below 2.0, exhibited reduced mite repellent efficacy over a long period of time compared to the mite repellent products of Examples 1 to 11. This is thought to be due to the fact that fragrance compounds with logP values ​​outside the range of 2.0 to 5.5 are somewhat inferior in controlling the volatilization of 1,8-cineole. A comparison of Examples 1 to 11 with Reference Examples 1 to 3 revealed that compounding (a) 1,8-cineole and / or 1,4-cineole with component (b) containing a fragrance compound with a logP value of 2.0 to 5.5 can further improve mite repellent efficacy over a long period of time.

[0053] Furthermore, the mite repellent products of Comparative Examples 1 and 2, which contained other citronellal or vetiver oil as component (a), showed insufficient mite repellent effect over a long period of time, even when they contained component (b) containing a fragrance compound with a logP value of 2.0 to 5.5. From this, it is believed that the phenomenon in which the fragrance compound with a logP value of 2.0 to 5.5 contained in component (b) effectively regulates the volatilization of pest repellent ingredients is specific to (a) 1,8-cineole and / or 1,4-cineole. [Industrial Applicability]

[0054] The mite repellent composition and mite repellent product of the present invention can be suitably used to repel house dust mites that lurk in bedding (mite repellent composition and mite repellent product for bedding), but can naturally also be used to repel a wide range of pests, not just house dust mites.

Claims

1. (a) 1,8-cineole and / or 1,4-cineole, (b) a fragrance ingredient; and A mite repellent composition comprising: the component (b) contains one or more fragrance compounds having a log P value of 2.0 to 5.5; the fragrance compound contained in the component (b) is citronellol and / or geranyl acetate, a blending ratio (a / b) of the component (a) to the fragrance compound contained in the component (b) is set to 5 to 100 on a mass basis; The amount of component (a) blended is 10 to 90% by mass (excluding cases where 3-(3,4-methylenedioxyphenyl)-2-methylpropanal and / or 3,4-methylenedioxybenzaldehyde is contained, and excluding cases where α-pinene is contained).

2. (a) 1,8-cineole and / or 1,4-cineole, (b) a fragrance ingredient; and A mite repellent composition comprising: the component (b) contains one or more fragrance compounds having a log P value of 2.0 to 5.5; The fragrance compound contained in the component (b) is limonene, a blending ratio (a / b) of the component (a) to the fragrance compound contained in the component (b) is set to 5 to 80 on a mass basis; The amount of component (a) blended is 10 to 90% by mass in the mite repellent composition (however, excluding cases where 3-(3,4-methylenedioxyphenyl)-2-methylpropanal and / or 3,4-methylenedioxybenzaldehyde is contained, excluding cases where camphor is contained, and excluding cases where α-pinene is contained).

3. A solid carrier containing the mite repellent composition according to claim 1 or 2; a breathable packaging material for storing or packaging the solid carrier; Tick ​​repellent products, including:

4. 4. The mite repellent product according to claim 3, wherein the solid carrier is a granular material having an average particle size of 1 to 8 mm.

5. 5. The mite repellent product according to claim 3, wherein the solid carrier contains 20 to 400 mg of the component (a) per gram.

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