Liquid composition

A liquid composition for oxycodone using acesulfame potassium, xylitol, D-sorbitol, and L-glutamic acid, with a pH of 3.3 to 4.8, addresses bitterness masking and stability issues, providing a stable and palatable oral formulation.

JP7768561B2Active Publication Date: 2025-11-12NIPPON ZOKI PHARMACEUTICAL CO LTD
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Patent Information

Application Number
JP2022539558
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2020-07-30
Filing Date
2021-07-29
Publication Date
2025-11-12
Estimated Expiration
2041-07-29

AI Technical Summary

Technical Problem

Existing oral liquid formulations of bitter active ingredients like oxycodone face challenges in masking bitterness and maintaining stability due to the formation of related substances, with existing methods either failing to mask bitterness or causing instability at different pH levels.

Method used

A liquid composition containing oxycodone with a specific combination of additives such as acesulfame potassium, xylitol, D-sorbitol, and L-glutamic acid, along with a pH adjustment between 3.3 to 4.8, effectively masks bitterness and suppresses the formation of related substances, ensuring stability.

Benefits of technology

The composition achieves reduced bitterness perception and enhanced stability, making it suitable for patient use while meeting pharmaceutical quality standards by minimizing related substance formation.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention addresses the problem of providing an orally administered liquid medicine that is made easy to take by masking the bitter taste of oxycodone, which is an active ingredient thereof, and that is also highly stable. The present invention provides a liquid medicine composition containing oxycodone as an active ingredient, the liquid medicine composition being highly stable, a bitter taste being masked by an additive in the liquid medicine composition, and the formation of analogues being suppressed by adjusting the pH of the liquid medicine composition to within a prescribed range.
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Citation Information

Patent Citations

  • Glutamic salt-containing liquid preparation

    JP2000204036A

  • Method for producing pharmaceutical composition for an injection

    JP2016121073A