Bactericidal cleaning agent composition

Abstract

To provide bactericidal detergent compositions having excellent bactericidal activity, low irritation to the skin, excellent non-stickiness when drying, excellent dry feeling after drying, and good solubility of ingredients contained therein.SOLUTION: Provided is a bactericidal detergent composition comprising: (A) at least one quaternary ammonium compound selected from the group consisting of benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; (B) at least one surfactant selected from the group consisting of amphoteric surfactants and semipolar surfactants; and (C) an amino acid-based cationic surfactant, the content of (D) a monohydric alcohol having 1 to 3 carbon atoms being less than 10 mass%, the mass ratio [(C) / (B)] of the content of component (C) to the content of component (B) being 0.25 to 25.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a germicidal cleaning composition. [Background technology]

[0002] Conventionally, ethanol preparations have been commonly used as disinfectant and cleaning compositions for hands, but ethanol has drawbacks such as an alcohol odor and irritation during use, and dryness of the skin after use (see, for example, Patent Document 1). However, if the ethanol content is reduced to reduce the alcohol irritation, there is a problem that the disinfecting power is reduced.

[0003] Therefore, in order to improve the bactericidal power of a germicidal detergent composition, a germicidal cleaning composition containing a quaternary ammonium compound has been proposed (see, for example, Patent Document 2). However, germicidal cleaning compositions with a low ethanol content have the problem of poor usability, such as stickiness when drying and a smooth feeling after drying.

[0004] Therefore, although conventional bactericidal cleaning agent compositions have bactericidal activity and can reduce alcohol irritation, they have been insufficient in combining these effects with a feeling of use, such as a lack of stickiness when drying and a smooth feeling after drying.

[0005] In light of this background, there is a need for a bactericidal cleaning composition that has excellent bactericidal activity, is low in irritation to the skin, has an excellent feel when used, such as being non-sticky when drying and having a smooth feel after drying, and also has a good appearance. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] Japanese Patent Application Laid-Open No. 2011-153089 [Patent Document 2] Patent Publication No. 2021-100915 Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention aims to solve the above-mentioned problems of the prior art and to achieve the following object: That is, the present invention aims to provide a bactericidal detergent composition that has excellent bactericidal activity, is low in irritation to the skin, is non-sticky when drying, has an excellent smooth feeling after drying, and has good solubility of the components contained therein. [Means for solving the problem]

[0008] As a result of intensive research conducted by the present inventors to achieve the above-mentioned object, they have found that a bactericidal detergent composition containing (A) at least one quaternary ammonium compound selected from the group consisting of benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride, (B) at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants, and (C) an amino acid-derived cationic surfactant, in which the content of (D) a monohydric alcohol having 1 to 3 carbon atoms is less than 10 mass%, and the mass ratio of the content of the content of the (C) component to the content of the (B) component [(C) / (B)]] is 0.25 to 25, has excellent bactericidal activity, is low in irritation to the skin, is non-sticky when drying, has an excellent smooth feeling after drying, and has good solubility of the contained components, which has led to the completion of the present invention.

[0009] The present invention is based on the above findings by the present inventors, and the means for solving the above problems are as follows: <1> (A) at least one quaternary ammonium compound selected from the group consisting of benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; (B) at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants; (C) an amino acid-based cationic surfactant; Contains (D) the content of monohydric alcohols having 1 to 3 carbon atoms is less than 10% by mass, The germicidal detergent composition is characterized in that the mass ratio of the content of the component (C) to the content of the component (B) [(C) / (B)] is 0.25 to 25. <2> The content of the component (A) is 0.01% by mass to 0.2% by mass, The content of the (B) component is 0.1% by mass to 0.4% by mass, The content of the component (C) is 0.1% by mass to 2% by mass. <1> The disinfectant cleaning composition is as described above. <3> The above-mentioned disinfectant and cleaning composition is a leave-on type. <1> from <2> The bactericidal cleaning composition according to any one of the above items. [Effects of the Invention]

[0010] According to the present invention, it is possible to solve the above-mentioned problems of the prior art and achieve the above-mentioned object, and to provide a bactericidal cleaning agent composition which has excellent bactericidal activity, is low in irritation to the skin, is non-sticky when drying, has an excellent smooth feeling after drying, and has good solubility of the ingredients contained therein. DETAILED DESCRIPTION OF THE INVENTION

[0011] (Bactericidal cleaning agent composition) The bactericidal detergent composition of the present invention contains (A) at least one quaternary ammonium compound selected from the group consisting of benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride, (B) at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants, and (C) an amino acid-based cationic surfactant, and may further contain other ingredients as necessary. The germicidal detergent composition of the present invention may contain (D) a monohydric alcohol having 1 to 3 carbon atoms, but the content thereof is less than 10 mass %.

[0012] <(A) Quaternary ammonium compounds> The quaternary ammonium compound as component (A) is contained mainly to improve the disinfecting power.

[0013] The quaternary ammonium compound of the component (A) is at least one selected from the group consisting of benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride, with benzalkonium chloride being preferred from the standpoint of bactericidal power.

[0014] The quaternary ammonium compound of the component (A) may be an appropriately synthesized compound or a commercially available product.

[0015] Examples of commercially available benzalkonium chloride products as the quaternary ammonium compound of component (A) include CATION G-50 (manufactured by Sanyo Chemical Industries, Ltd.), NIKKOL CA-101 (manufactured by Nikko Chemicals Co., Ltd.), NISSAN CATION (registered trademark) M2-100R (manufactured by NOF Corporation), and NISSAN CATION (registered trademark) F2-50E (manufactured by NOF Corporation).

[0016] Commercially available benzethonium chloride as the quaternary ammonium compound of the component (A) includes, for example, trade names such as Lonzagard Benzethonium Chloride (manufactured by Mitsubishi Chemical Corporation) and Benzethonium Chloride (manufactured by Tokyo Chemical Industry Co., Ltd.).

[0017] An example of a commercially available product of cetylpyridinium chloride as the quaternary ammonium compound of the component (A) is the product name cetylpyridinium chloride (CPC) (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0018] The content of the quaternary ammonium compound of the component (A) is not particularly limited and can be appropriately selected depending on the purpose. The lower limit can be, for example, 0.005% by mass or more, 0.01% by mass or more, based on the total amount of the germicidal detergent composition. The upper limit can be, for example, 0.5% by mass or less, 0.2% by mass or less, based on the total amount of the germicidal detergent composition. From the viewpoints of germicidal power and irritation to hand skin, the content is preferably 0.005% by mass to 0.5% by mass, more preferably 0.01% by mass to 0.2% by mass, based on the total amount of the germicidal detergent composition. When the content of the quaternary ammonium compound of the component (A) is 0.005% by mass or more, the germicidal power is good, and when it is 0.5% by mass or less, the irritation to hand skin is low, which is preferable.

[0019] <(B) At least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants> The at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants as component (B) is contained mainly to improve the solubility of the components contained therein, particularly the solubility of component (C).

[0020] The present inventors have found that the amino acid cationic surfactant (C) has good solubility in conventional ethanol preparations, but is poorly soluble in aqueous solvents with low ethanol content. To address this problem, the present inventors have conducted extensive research and found that the solubility of the (C) component can be improved by adding at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants (B) and by setting the mass ratio of the (C) component to the (B) component [(C) / (B)] within a specific range. Therefore, the germicidal detergent composition of the present invention has a clear appearance due to the good solubility of the components contained therein.

[0021] <<Amphoteric surfactants>> The amphoteric surfactant of the component (B) is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include alkylbetaine-type amphoteric surfactants, amidobetaine-type amphoteric surfactants, sulfobetaine-type amphoteric surfactants, imidazoline-type amphoteric surfactants, etc. These may be used alone or in combination of two or more.

[0022] The alkyl betaine type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl dimethyl amino acetic acid betaine (lauryl betaine), coconut oil dimethyl amino acetic acid betaine (coconut oil alkyl betaine), stearyl dimethyl amino acetic acid betaine (stearyl betaine), etc. These may be used alone or in combination of two or more.

[0023] The amidobetaine amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauric acid amidopropyl dimethylaminoacetic acid betaine (lauric acid amidopropyl betaine), coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine (coconut oil fatty acid amidopropyl betaine), palm kernel oil fatty acid amidopropyl dimethylaminoacetic acid betaine (palm kernel oil fatty acid amidopropyl betaine), etc. These may be used alone or in combination of two or more.

[0024] The sulfobetaine-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include lauryl hydroxysulfobetaine, lauramidopropyl hydroxysultaine, etc. These may be used alone or in combination of two or more.

[0025] The imidazoline-type amphoteric surfactant is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine.

[0026] The amphoteric surfactant of the component (B) may be an appropriately synthesized product or a commercially available product.

[0027] Commercially available alkyl betaine amphoteric surfactants as the amphoteric surfactant of component (B) include, for example, Nissan Anon (registered trademark) BL (lauryl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BF (coconut oil dimethylaminoacetic acid betaine, manufactured by NOF Corporation), NIKKOL Examples of such an agent include AM-301 (lauryl dimethyl aminoacetic acid betaine, manufactured by Nikko Chemicals Co., Ltd.), Amogene S (lauryl betaine, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), Obazoline LB (lauryl dimethyl aminoacetic acid betaine, manufactured by Toho Chemical Industry Co., Ltd.), Rekabion A-100 (lauryl dimethyl aminoacetic acid betaine solution, manufactured by New Japan Chemical Co., Ltd.), Anhithol 20BS (lauryl dimethyl aminoacetic acid betaine, manufactured by Kao Corporation), Anhithol 24B (lauryl dimethyl aminoacetic acid betaine, manufactured by Kao Corporation), Anhithol 86B (stearyl dimethyl aminoacetic acid betaine, manufactured by Kao Corporation), and Rekabion A-700 (stearyl betaine, manufactured by New Japan Chemical Co., Ltd.).

[0028] Commercially available amidobetaine amphoteric surfactants as the amphoteric surfactant of component (B) include, for example, trade names such as NIKKOL AM-3130N (coconut oil fatty acid amidopropyl betaine liquid, manufactured by Nikko Chemicals Co., Ltd.), Nissan Anon (registered trademark) BDL-SF (lauric acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BDF-SF (coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), Nissan Anon (registered trademark) BDC-SF (palm kernel oil fatty acid amidopropyl dimethylaminoacetic acid betaine, manufactured by NOF Corporation), and Amphithol 2 Examples include 0AB (lauric acid amidopropyl betaine solution, manufactured by Kao Corporation), Amphitol 55AB (coconut oil fatty acid amidopropyl betaine solution, manufactured by Kao Corporation), Softazoline CPB (coconut oil fatty acid amidopropyl betaine solution, manufactured by Kawaken Fine Chemicals Co., Ltd.), Softazoline LPB (lauric acid amidopropyl betaine solution, manufactured by Kawaken Fine Chemicals Co., Ltd.), and Softazoline PKPB (palm kernel oil fatty acid amidopropyl betaine solution, manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0029] Commercially available sulfobetaine-type amphoteric surfactants as the amphoteric surfactant of component (B) include, for example, trade names such as Amphitol 20HD (lauryl hydroxysulfobetaine liquid, manufactured by Kao Corporation) and Softazoline LSB (lauramidopropyl hydroxysultaine, manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0030] Commercially available imidazoline-type amphoteric surfactants as the amphoteric surfactant of component (B) include, for example, trade names such as NIKKOL AM-101 (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Nikko Chemicals Co., Ltd.), Nissan Anon (registered trademark) GLM-R-LV (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by NOF Corporation), Amphitol 20Y-B (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kao Corporation), and Softazoline CL (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, manufactured by Kawaken Fine Chemicals Co., Ltd.).

[0031] <<Semi-polar surfactants>> The semi-polar surfactant of component (B) is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include amine oxide surfactants, etc. These may be used alone or in combination of two or more.

[0032] The amine oxide surfactant is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include alkyl dimethyl amine oxide, lauryl dimethyl amine oxide, coconut oil alkyl dimethyl amine oxide, myristyl dimethyl amine oxide, lauric acid amide propyl dimethyl amine oxide, etc. These may be used alone or in combination of two or more.

[0033] The semi-polar surfactant of the component (B) may be suitably synthesized or may be a commercially available product.

[0034] Examples of commercially available semi-polar surfactants of component (B) include, by trade name, Amphitol 20N (lauryl dimethylamine oxide liquid, manufactured by Kao Corporation), Softazoline LAO (lauric acid amidopropyl dimethylamine oxide liquid, manufactured by Kawaken Fine Chemicals Co., Ltd.), AX-S (lauryl dimethylamine oxide, manufactured by Lion Specialty Chemicals Co., Ltd.), Cadenax DMC-W (coconut oil alkyl dimethylamine oxide liquid, manufactured by Lion Specialty Chemicals Co., Ltd.), Cadenax DM14D-N (myristyl dimethylamine oxide, manufactured by Lion Specialty Chemicals Co., Ltd.), and Cadenax APA-12W (lauryl dimethylamine oxide, manufactured by Lion Specialty Chemicals Co., Ltd.).

[0035] Among these, as the at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants of component (B), from the viewpoint of the solubility of the components contained therein, semi-polar surfactants are preferred, alkyldimethylamine oxides are more preferred, and lauryldimethylamine oxide is particularly preferred.

[0036] The content of at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants in the (B) component is not particularly limited and can be appropriately selected according to the purpose. The lower limit can be, for example, 0.05% by mass or more, 0.1% by mass or more, based on the total amount of the bactericidal detergent composition. The upper limit can be, for example, 1% by mass or less, 0.4% by mass or less, based on the total amount of the bactericidal detergent composition. However, from the viewpoint of the solubility of the components, non-stickiness when drying, and smooth feeling after drying, the content is preferably 0.05% by mass to 1% by mass, more preferably 0.1% by mass to 0.4% by mass, based on the total amount of the bactericidal detergent composition. When the content of at least one surfactant selected from the group consisting of amphoteric surfactants and semi-polar surfactants in the (B) component is 0.05% by mass or more, the solubility of the components is good, and when it is 1% by mass or less, the non-stickiness when drying and smooth feeling after drying are good.

[0037] <(C) Amino acid-based cationic surfactant> The amino acid-based cationic surfactant as component (C) is contained mainly to improve the lack of stickiness when drying and the smooth feeling after drying.

[0038] The amino acid cationic surfactant of component (C) is not particularly limited and can be selected appropriately depending on the purpose, but N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate is preferred from the viewpoints of non-stickiness upon drying and a smooth feel after drying.

[0039] The amino acid-based cationic surfactant of the component (C) may be suitably synthesized or may be a commercially available product.

[0040] Examples of commercially available amino acid-based cationic surfactants of component (C) include those under the trade name CAE (registered trademark) (manufactured by Ajinomoto Healthy Supply Co., Ltd.).

[0041] The content of the amino acid cationic surfactant of the component (C) is not particularly limited and can be appropriately selected according to the purpose. The lower limit thereof is, for example, 0.05% by mass or more, 0.1% by mass or more, based on the total amount of the germicidal detergent composition. The upper limit thereof is, for example, 3% by mass or less, 2% by mass or less, based on the total amount of the germicidal detergent composition. However, from the viewpoints of the solubility of the components, non-stickiness upon drying, and smooth feeling after drying, the content is preferably 0.05% by mass to 3% by mass, more preferably 0.1% by mass to 2% by mass, based on the total amount of the germicidal detergent composition. When the content of the amino acid cationic surfactant of the component (C) is 0.05% by mass or more, the non-stickiness upon drying and smooth feeling after drying are good, and when it is 3% by mass or less, the solubility of the components is good.

[0042] <<Mass ratio [(C) / (B)]>> The mass ratio [(C) / (B)] of the content (mass%) of the (C) component to the content (mass%) of the (B) component is 0.25 to 25, preferably 0.5 to 15, from the viewpoints of the solubility of the components, non-stickiness upon drying, and a smooth feel after drying. If the mass ratio [(C) / (B)] is less than 0.25, the composition becomes sticky upon drying and does not have a smooth feel after drying. If the mass ratio [(C) / (B)] is more than 25, the solubility of the components is poor, and the composition becomes cloudy. On the other hand, if the mass ratio [(C) / (B)] is 0.25 to 25, the solubility of the components is good, so the composition becomes clear, and the composition is non-sticky upon drying and has a smooth feel after drying.

[0043] <(D) Monohydric Alcohol Having 1 to 3 Carbon Atoms> The germicidal detergent composition may contain a monohydric alcohol having 1 to 3 carbon atoms as the component (D).

[0044] The monohydric alcohol having 1 to 3 carbon atoms of the component (D) is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include ethanol, isopropyl alcohol, etc. These may be used alone or in combination of two or more. Among these, ethanol is preferred because it is less irritating to the skin.

[0045] The monohydric alcohol having 1 to 3 carbon atoms of the component (D) may be appropriately synthesized or may be a commercially available product.

[0046] Examples of commercially available monohydric alcohols having 1 to 3 carbon atoms as component (D) include 95% synthetic specified alcohol (ethanol, manufactured by Shinwa Alcohol Industry Co., Ltd.) and isopropyl alcohol (Godo Co., Ltd.).

[0047] The content of the monohydric alcohol having 1 to 3 carbon atoms in the component (D) is less than 10% by mass, preferably 5% by mass or less, and more preferably 0.01% by mass or less, of the total amount of the leave-on germicidal detergent composition, from the viewpoint of irritation to hand skin. If the content of the monohydric alcohol having 1 to 3 carbon atoms in the component (D) is 10% by mass or more, irritation to hand skin becomes strong.

[0048] <Other ingredients> In addition to the components (A), (B), (C), and (D), the bactericidal detergent composition may contain other components that are commonly used in bactericidal detergent compositions, etc., as needed, within the scope that does not impair the effects of the present invention.

[0049] The other components are not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include water, water-soluble polymers, oils, silicones, aromatic alcohols, lanolin derivatives, protein derivatives, pharmaceuticals such as vitamins, disinfectants other than the component (A), surfactants other than the components (B) and (C), preservatives, pH adjusters, antioxidants, sequestering agents, ultraviolet absorbers, animal and plant extracts or derivatives thereof, pigments, fragrances, etc. These may be used alone or in combination of two or more.

[0050] The pH adjuster is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include alkali metal hydroxides, alkanolamines, organic acids or salts thereof, inorganic acids, etc. These may be used alone or in combination of two or more. Examples of the alkali metal hydroxide include potassium hydroxide and sodium hydroxide. Examples of the alkanolamine include triethanolamine, 2-amino-2-methyl-1-propanol, and diisopropanolamine. Examples of the organic acid or a salt thereof include citric acid, sodium citrate, succinic acid, and glycolic acid. Examples of the inorganic acid include sulfuric acid, phosphoric acid, and hydrochloric acid.

[0051] The content of the other components can be a commonly used content within the range that does not impair the effects of the present invention.

[0052] -pH- The bactericidal detergent composition preferably has a pH at 25°C of 4.5 or more and 11 or less, more preferably 5 or more and 8 or less, from the viewpoints of bactericidal activity, solubility, and skin irritation.

[0053] The pH can be measured in an environment of 25° C. using, for example, a glass electrode hydrogen ion concentration indicator (device name: pH meter HM-30R type, manufactured by DKK-TOA Corporation, electrode type: GST-5721).

[0054] -container- The germicidal cleaning agent composition can be used by being filled in a container. The container is not particularly limited and can be appropriately selected depending on the purpose, but a pump dispenser container is preferred. The pump dispenser container is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include a pump dispenser container (nozzle diameter (inner diameter): 3.5 mm, discharge amount: 0.5 mL). The pump dispenser container may be a commercially available product, such as a pump dispenser container (manufactured by Yoshino Kogyosho Co., Ltd.).

[0055] -Manufacturing method- The method for producing the bactericidal detergent composition is not particularly limited and can be appropriately selected depending on the purpose. For example, in an environment of room temperature (e.g., 25 ° C), the (A) component, the (B) component, the (C) component, and the (D) component, as well as other components as necessary, are mixed in water, and each component is dissolved while stirring. If a predetermined pH is to be adjusted thereafter, a pH adjuster may be added while stirring to adjust the pH to the predetermined value. Finally, it is preferable to add water so that the total amount of the bactericidal detergent composition becomes 100% by mass.

[0056] The bactericidal detergent composition may be prepared using an apparatus. The apparatus is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include a stirring apparatus equipped with stirring blades that exert shear force and can mix the entire composition. The stirring blade is not particularly limited and can be appropriately selected depending on the purpose. Examples thereof include a propeller, a turbine, and a disperser.

[0057] -How to use- The method of use of the bactericidal detergent composition is not particularly limited and can be appropriately selected depending on the purpose, but it is preferably used as a leave-in type bactericidal detergent composition that does not require rinsing with water or the like after use of the bactericidal detergent composition on the application site such as the skin of the hands. Specifically, the leave-in type bactericidal detergent composition is one that does not require rinsing with tap water or the like after rubbing the bactericidal detergent composition into the palms and backs of the hands. The bactericidal detergent composition is advantageous in that not rinsing improves bactericidal power and ease of use.

[0058] -Applications- The use of the bactericidal detergent composition is not particularly limited and can be appropriately selected depending on the purpose, and can be suitably used, for example, as a hand disinfectant. The bactericidal detergent composition can also be used for body applications other than hands, such as for the body. Examples of application sites include hospitals, nursing homes, kitchens, etc., and it can also be suitably used at home. [Example]

[0059] The present invention will be specifically explained below with reference to examples and comparative examples, but the present invention is not limited to these examples in any way. The content of each component in the examples and comparative examples is expressed in "% by mass," and is all calculated as a pure content. However, for component (D), a 95% synthetic alcohol (manufactured by Shinwa Alcohol Industry Co., Ltd.) was used, and the value calculated as anhydrous ethanol (content (% by mass) converted to anhydrous ethanol) was reported. The mass ratio of the content (% by mass) of component (C) to the content (% by mass) of component (B) [(C) / (B)] was rounded to two decimal places and reported.

[0060] (Examples 1 to 22 and Comparative Examples 1 to 7) According to the compositions and contents (mass %) shown in Tables 1 to 4 below, the germicidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7 were prepared based on the following manufacturing method.

[0061] -Preparation of germicidal cleaning agent composition- In an environment of 25 ° C., component (A), component (B), component (C), and component (D) were mixed in this order with an appropriate amount of purified water, and each component was dissolved with stirring to prepare a solution. Then, while stirring the solution, potassium hydroxide or citric acid was appropriately added as a pH adjuster to adjust the pH to 5 to 8. Then, purified water was added so that the total amount of each germicidal detergent composition was 100 mass %, and each of the leave-in germicidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7 was obtained. A propeller was used as the stirring blade, and stirring was carried out using a Three-One Motor (trade name: HEIDON BL1200, manufactured by Shinto Chemical Co., Ltd.).

[0062] The obtained germicidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7 were evaluated for "sterilizing power," "non-stickiness when drying," "smooth feeling after drying," "irritation to hand skin," and "solubility" based on the following evaluation methods. The evaluation results are shown in Tables 1 to 4 below.

[0063] <Bactericidal power> The target bacteria is E. coli ( Escherichia coli NBRC3972: Gram-negative bacteria, obtained from the National Institute for Product Evaluation and Research) or Staphylococcus aureus ( Staphylococcus aureus Using NBRC12732 (Gram-positive bacterium, obtained from the National Institute of Product Evaluation and Evaluation), the bactericidal activity of each of the bactericidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7 was evaluated by the quantitative suspension method described below.

[0064] The E. coli or the S. aureus was statically cultured under aerobic conditions at 37°C for 18 to 24 hours using SCDLP (Soybean Casein Digest Agar with Lecitin) agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.). Next, an appropriate amount of colonies formed on the SCDLP agar medium was scraped off and suspended in physiological saline (Otsuka Pharmaceutical Co., Ltd.) to a bacterial concentration of 10. 8 The test bacterial solution was prepared so that the concentration was cfu / mL, where cfu means colony forming unit. Next, 0.05 mL of the test bacterial solution was added to 0.45 mL of each of the germicidal cleaning agent compositions of Examples 1 to 22 and Comparative Examples 1 to 7, and mixed. After 30 seconds, the mixture was immediately diluted 10-fold with SCDLP liquid medium (manufactured by Nippon Pharmaceutical Co., Ltd.) and inactivated. The inactivated solution was then serially diluted 10-fold with SCDLP liquid medium, i.e., 100-fold, 1,000-fold, and 10,000-fold. Subsequently, 0.1 mL of each diluted inactivated solution (n=3) was inoculated onto SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd., 9 cm Petri dishes) and statically cultured at 37°C for 24 hours under aerobic conditions using the pour plate culture method. After incubation, the total number of colonies formed was counted, and the number of remaining viable bacteria was measured. If no colonies were observed, the number of remaining viable bacteria was considered to be less than the detection limit of 10 cfu / mL. The bactericidal activity of each bactericidal detergent composition was scored based on the measured number of remaining viable bacteria, according to the following criteria. The "bactericidal activity" was evaluated based on the average of the scores, according to the following criteria. - Criteria for determining "bactericidal activity" - 5 points: The number of remaining viable bacteria is less than 10 cfu / mL (below the detection limit) 4 points: Residual viable bacteria count is 10 cfu / mL or more but less than 100 cfu / mL 3 points: Residual viable bacteria count is 100 cfu / mL or more but less than 1,000 cfu / mL 2 points: Residual viable bacteria count is 1,000 cfu / mL or more and less than 10,000 cfu / mL 1 point: Residual viable bacteria count is 10,000 cfu / mL or more -Evaluation criteria for "sterilization power"- ◎: The average score is 4.0 to 5.0 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0065] <No stickiness on hands as they dry> In an environment of 25°C, 10 expert panelists (5 men and 5 women) rubbed 0.5 g of each of the germicidal cleaning compositions of Examples 1 to 22 and Comparative Examples 1 to 7 into the palms and backs of their hands, and then scored the non-stickiness of the skin on their hands immediately after rubbing them in, based on the following criteria. The "non-stickiness of the skin on their hands when drying" was evaluated based on the average of the scores, based on the following criteria. - Criteria for determining "non-stickiness when drying" - 5 points: No sticky feeling on hands 4 points: Almost no stickiness on hands 3 points: Slight stickiness on hands, but not a problem 2 points: Sticky feeling on hands 1 point: My hands feel very sticky -Evaluation criteria for "non-stickiness when drying"- ◎: The average score is 4.0 to 5.0 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0066] <Smooth feeling on hands after drying> In an environment of 25°C, 10 expert panelists (5 men and 5 women) rubbed 0.5 g of each of the germicidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7 into the palms and backs of their hands, and after drying, scored the smooth feeling of the skin on their hands based on the following criteria. The "smooth feeling of the skin on their hands after drying" was evaluated based on the average of the scores, based on the following criteria. -Criteria for judging "smoothness of hands after drying"- 5 points: My hands feel very smooth 4 points: Feels smooth on hands 3 points: Feels slightly smooth on hands 2 points: I don't feel much smoothness on my hands. 1 point: No dry feeling on hands -Evaluation criteria for "smoothness of hands after drying"- ◎: The average score is 4.0 to 5.0 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0067] <Irritation to hands> In an environment of 25°C, 10 expert panelists (5 men and 5 women) rubbed 0.5 g of each of the germicidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7 into the palms and backs of their hands, and then scored the irritation to the skin of their hands based on the following criteria. The "irritation to the skin of the hands" was evaluated based on the average of the scores, based on the following criteria. -Criteria for determining "irritation to hand skin"- 5 points: No irritation to the skin 4 points: Almost no irritation to the skin 3 points: Slight irritation to the skin, but not a problem 2 points: I feel irritation on my hands 1 point: Strong irritation to the skin on the hands -Evaluation criteria for "irritation to hand skin"- ◎◎: The average score is between 4.5 and 5.0 points ◎: The average score is 4.0 or more and less than 4.5 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 points or more and less than 3.0 points ×: The average score is less than 2.0 points

[0068] <Solubility> In the manufacturing process of each of the germicidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7, the appearance of the sample immediately after adding component (C) was visually observed by one expert panelist. Next, 50 mL of each of the finally obtained germicidal detergent compositions was filled into three 50 mL glass screw vials (product name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.), and the appearance of the samples immediately after was visually observed by the same expert panelist, and the solubility of the components contained in each germicidal detergent composition was scored based on the following evaluation criteria. The "solubility" was evaluated based on the average of the scores and the following evaluation criteria. - Criteria for determining "solubility" - 5 points: No turbidity is observed and the liquid is clear 4 points: Slight turbidity is observed during the manufacturing process, but the solution dissolves quickly and becomes almost clear. 3 points: Cloudiness is observed during the manufacturing process, but it gradually dissolves and is at a level that does not pose a problem as a composition. 2 points: Cloudiness of insoluble matter is observed throughout 1 point: Insoluble matter precipitates -Evaluation criteria for "solubility"- ◎: The average score is 4.0 to 5.0 points ○: The average score is 3.0 or more and less than 4.0 points △: The average score is 2.0 or more and less than 3.0 points ×: The average score is less than 2.0 points

[0069] [Table 1]

[0070] [Table 2]

[0071] [Table 3]

[0072] [Table 4]

[0073] The raw materials used in each of the germicidal detergent compositions of Examples 1 to 22 and Comparative Examples 1 to 7 are as shown in Table 5 below.

[0074] [Table 5] [Industrial Applicability]

[0075] The bactericidal detergent composition of the present invention has excellent bactericidal activity, low irritation to the skin, no stickiness when drying, excellent smooth feeling after drying, and good solubility of the contained components, so it can be suitably used, for example, as a hand disinfectant. In addition, the bactericidal detergent composition of the present invention can also be used for body applications other than hands, such as body applications. Its application sites include, for example, hospitals, nursing homes, kitchen applications, etc., and it can also be suitably used at home.

Claims

1. (A) at least one quaternary ammonium compound selected from the group consisting of benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride; (B) at least one surfactant selected from the group consisting of alkylbetaine-type amphoteric surfactants and amine oxide-type surfactants; (C) an amino acid-based cationic surfactant; Contains (D) the content of monohydric alcohols having 1 to 3 carbon atoms is less than 10% by mass, the component (C) is N-cocoyl L-arginine ethyl DL-pyrrolidone carboxylate, The content of the component (A) is 0.005% by mass to 0.5% by mass, The content of the component (B) is 0.05% by mass to 0.5% by mass, A bactericidal detergent composition characterized in that the mass ratio [(C) / (B)] of the content of the (C) component to the content of the (B) component is 0.67 to 25.

2. The content of the (A) component is 0.01% by mass to 0.2% by mass, The content of the (B) component is 0.1% by mass to 0.4% by mass, The bactericidal cleaning agent composition according to claim 1, wherein the content of the component (C) is 0.1% by mass to 2% by mass.

3. 3. The bactericidal cleaning composition according to claim 1, which is a leave-on type bactericidal cleaning composition.

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