Oil-based emulsions in water

Abstract

To provide an oil-in-water emulsion composition comprising a heparin-like substance and having excellent smooth spreadability and richness during application, as well as having excellent firmness, non-stickiness, and penetration after application.SOLUTION: An oil-in-water emulsion composition comprises: (A) a heparin-like substance; (B) 3 to 15% by mass of an oil agent that is in paste form at 25°C; (C) hydrogenated polyisobutene; and (D) one or more selected from polyoxyalkylene alkyl glucoside, polyoxyalkylene glyceryl ether, and polyoxyalkylene diglyceryl ether. The ratio (C) / {(C)+(D)} of the mass content of component (C) to the total mass content of components (C) and (D) is 0.4 to 0.9.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oil-in-water emulsion composition containing a heparinoid. [Background technology]

[0002] Heparinoids are polysulfated mucopolysaccharides such as chondroitin polysulfate, and are used as active ingredients in external skin preparations because they have excellent moisturizing, blood circulation promoting, anti-inflammatory, etc. In recent years, there has been active development of heparinoid-containing preparations that provide an excellent feel when applied (see, for example, Patent Document 1), and various products have been proposed.

[0003] Meanwhile, rising consumer demand for convenient skincare has led to an increase in all-in-one products that combine multiple functions. Oil-in-water emulsion compositions using heparinoids can combine the moisturizing and freshness of the heparinoid in the aqueous phase with the occlusive effect and richness of the oil, making them a suitable formulation for all-in-one products. Known examples of such oil-in-water emulsion compositions include a technology for oil-in-water emulsion compositions containing a heparinoid and one or more oil-soluble components selected from the group consisting of oil-soluble acylamino acids, derivatives thereof, and salts thereof, and paste-like oils (see Patent Document 2). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 2019-119690 [Patent Document 2] Patent Publication No. 2021-059525 Summary of the Invention [Problem to be solved by the invention]

[0005] However, the technology disclosed in Patent Document 1 is excellent in stability and smoothness upon application, but may be sticky after use due to the water-soluble polymer.Furthermore, the technology disclosed in Patent Document 2 is excellent in freshness upon application and good compatibility with the skin after use, but may be unsatisfactory in terms of stickiness due to the paste-like oil and reduced spreadability upon application.

[0006] Therefore, an object of the present invention is to provide an oil-in-water emulsion composition containing a heparin-like substance, which has a rich feeling due to the oil agent, but is not sticky after use and has excellent smooth spreadability. [Means for solving the problem]

[0007] In light of this situation, the present inventors have conducted extensive research and found that by combining a specific compound in an oil-in-water emulsion composition containing a heparinoid and an oil agent that is in a paste form at 25°C, the above-mentioned problems can be solved and excellent penetration and firmness can be achieved, thereby completing the present invention.

[0008] That is, the present invention provides the following. [1] An oil-in-water emulsion composition comprising the following components (A) to (D), wherein the ratio of the content of component (C) to the total content of components (C) and (D) is (C) / {(C)+(D)} 0.4 to 0.9: (A) Heparinoids (B) 3 to 15% by mass of an oil agent that is in a paste form at 25°C (C) Hydrogenated polyisobutene (D) one or more selected from polyoxyalkylene alkyl glucoside, polyoxyalkylene glyceryl ether, and polyoxyalkylene diglyceryl ether [2] The oil-in-water emulsion composition according to [1], wherein the content of the component (C) is 1 to 15% by mass, and the content of the component (D) is 0.5 to 8% by mass. [Effects of the Invention]

[0009] The oil-in-water emulsion composition of the present invention has a rich feel due to the oil agent, but is not sticky after use, has excellent smooth spreadability, and also has excellent penetration and firmness. Therefore, it is useful as an all-in-one skin care cosmetic or a highly moisturizing skin care cosmetic. DETAILED DESCRIPTION OF THE INVENTION

[0010] Hereinafter, embodiments of the present invention will be described. However, the present invention is not limited to the following embodiments. In this specification, the term "X to Y" indicating a range includes X and Y and means "X or more and Y or less."

[0011] (Component (A) Heparinoid) The heparinoid component (A) used in the present invention is a heparinoid defined in the Japanese Pharmacopoeia (JPN) Non-Drug Standards and is a polysulfated ester of mucopolysaccharide obtained by sulfated polysaccharides whose repeating units are disaccharides consisting of D-glucuronic acid and N-acetyl-D-galactosamine. Heparinoids are a general term for compounds with a chemical structure similar to that of heparin, a type of sugar produced in the human liver. Specific examples include cellulose sulfate, chitin sulfate, chitosan sulfate, pectin sulfate, chondroitin sulfate, inulin sulfate, alginate sulfate, glycogen sulfate, starch sulfate, polyvinyl alcohol sulfate, polyglucose sulfate, polylactose sulfate, laminarin sulfate, galactan sulfate, levan sulfate, and polysulfates and salts thereof. Heparinoids are known to have moisturizing and blood circulation-promoting effects.

[0012] In the present invention, heparinoids described in the Japanese Pharmacopoeia 2002 Standards for Pharmaceuticals and Medical Devices can be preferably used. The heparinoids defined in the Japanese Pharmacopoeia 2002 Standards for Pharmaceuticals and Medical Devices contain a polysulfate ester of chondroitin sulfate as the main component. There are no particular restrictions on the amount of organic sulfate groups in the heparinoid, and any can be used. However, from the viewpoints of moisturizing effect, usability, etc., the amount of organic sulfate groups is preferably 20 to 40 mass% (hereinafter simply abbreviated as %). The amount of organic sulfate groups in component (A) in the present invention can be measured by the method described in the quantitative determination method for "heparinoids" in the Japanese Pharmacopoeia 2002 Standards for Pharmaceuticals and Medical Devices.

[0013] The content of component (A) in the present invention is not particularly limited, but is preferably 0.001% or more, more preferably 0.01% or more, and even more preferably 0.05% or more, based on the total amount of the oil-in-water emulsion composition. Also, it is preferably 5% or less, more preferably 1% or less, even more preferably 0.8% or less, and particularly preferably 0.5% or less. This range is preferable because it provides no stickiness after use and has excellent moisturizing effects.

[0014] (Component (B) is an oil that is paste-like at 25°C) The oil component (B) used in the present invention may be any oil commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., regardless of its polarity or non-polarity, and should be paste-like at 25°C. Component (B) refers to a polar oil that has a melting point above 25°C and a viscosity of 5,000 to 100,000 mPa·s at 30°C. In the present invention, the viscosity is measured using a single-cylinder rotational viscometer, Vismetron Model VS-A1 (manufactured by Shibaura Systems Co., Ltd.), after leaving the sample at 30°C for one day. The melting point is not particularly limited, but is preferably 27 to 60°C, and more preferably 30 to 55°C.

[0015] Specific examples include hydrocarbon oils such as petrolatum, and polar oils such as ester oils, such as N-acylamino acid esters, glycerin fatty acid esters, dimer acid esters, dipentaerythritol fatty acid esters, fatty acid cholesteryl esters, and fatty acid phytosteryl esters. More specifically, N-acyl amino acid esters such as dioctyldodecyl N-lauroyl-L-glutamate, di(cholesteryl / octyldodecyl) N-lauroyl-L-glutamate, di(cholesteryl / behenyl / octyldodecyl) N-lauroyl-L-glutamate, di(phytosteryl / behenyl / octyldodecyl) N-lauroyl-L-glutamate, di(phytosteryl / behenyl / octyldodecyl) N-lauroyl-L-glutamate, hexaglycerin fatty acid esters, decaglycerin fatty acid esters, glyceryl oligoesters (adipic acid / 2-ethylhexanoic acid / stearic acid), hydrogenated castor oil stearate, caprylic / capric / myristic / stearic triglyceride, bis-diglyceryl polyacyladipate-2, hydrogenated castor oil hydroxystearate, and other glycerin fatty acid esters, phytosteryl / isostearyl dimer dilinoleate, / cetyl / stearyl / behenyl), dimer acid esters such as di(isostearyl / phytosteryl) dimer dilinoleate and dimer dilinoleyl bisisostearyl dimer dilinoleate; dipentaerythritol fatty acid esters such as (12-hydroxystearic acid / stearic acid / rosin acid) dipentaerythritol hexa(hydroxystearic acid / stearic acid / rosin acid) dipentaerythritol (12-hydroxystearic acid / isostearic acid); fatty acid cholesteryl esters such as cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl ricinoleate; fatty acid phytosteryl esters such as macadamia nut oil fatty acid phytosteryl; and the like. These can be used alone or in combination as needed. Among these, from the viewpoint of richness and stability of the oil-in-water emulsion composition, phytosteryl oleate, phytosteryl macadamia nut oil fatty acid, and di(phytosteryl / behenyl / octyldodecyl) N-lauroyl-L-glutamate are preferred.

[0016] The content of component (B) in the present invention is 3 to 15% of the total amount of the oil-in-water emulsion composition. If it is less than 3%, a sufficient richness may not be obtained, and if it exceeds 15%, the composition may be inferior in terms of non-stickiness and smooth spreadability. The content of component (B) is more preferably 5% or more, more preferably 12% or less, and even more preferably 8% or less.

[0017] (Component (C) Hydrogenated Polyisobutene) The hydrogenated polyisobutene (component (C)) used in the present invention is a mixture of branched saturated hydrocarbons, and can be any that is commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc. The average molecular weight of component (C) is preferably 500 to 3000, and examples of commercially available products include purified polybutene HV-100F(SB) (manufactured by Nippon Natural Products Co., Ltd.), polybutene 100R, polybutene 300R, polybutene 300H, polybutene 2000H (all manufactured by Idemitsu Kosan Co., Ltd.), Pearleem 18 (average molecular weight: 1000), Pearleem 24 (average molecular weight: 1350), Pearleem 46 (average molecular weight: 2650) (all manufactured by NOF Corporation).

[0018] The content of component (C) in the present invention is not particularly limited, but is preferably 1% or more, more preferably 3% or more, based on the total amount of the oil-in-water emulsion composition. It is also preferably 15% or less, more preferably 12% or less. This range is more preferable because it provides excellent smooth spreadability and penetration, as well as non-stickiness and firmness.

[0019] (Component (D) One or more selected from polyoxyalkylene alkyl glucoside, polyoxyalkylene glyceryl ether, and polyoxyalkylene diglyceryl ether) In the present invention, the polyoxyalkylene alkyl glucoside of component (D) is obtained by addition polymerization of an alkylene oxide (oxyalkylene) to an alkyl glucoside. While there are no particular limitations on the oxyalkylene, as long as it is one that is commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., examples of the oxyalkylene to be addition-polymerized include ethylene, propylene, butylene, etc., with ethylene or propylene being preferred. The average number of moles of oxyalkylene added is preferably 5 to 40, more preferably 10 to 20. Furthermore, the alkyl group preferably has 1 to 4 carbon atoms, more preferably a methyl group. Specific examples of the polyoxyalkylene alkyl glucoside of component (D) include polyoxyethylene (10) methyl glucoside, polyoxyethylene (20) methyl glucoside, polyoxypropylene (10) methyl glucoside, and polyoxypropylene (20) methyl glucoside, with polyoxyethylene (10) methyl glucoside and polyoxypropylene (10) methyl glucoside being particularly preferred. Commercially available products such as Macbiobride MG-10E, Macbiobride MG-20E, and Macbiobride MG-10P (all manufactured by NOF Corporation), GLUCAME E-10 LFG, and GLUCAME P-10 (all manufactured by LUBRIZOL ADVANCED MATERIALS) can also be used.

[0020] The polyoxyalkylene glyceryl ether and polyoxyalkylene diglyceryl ether (Component (D)) used in the present invention are obtained by addition polymerization of alkylene oxide with glycerin or diglycerin. While there are no particular limitations on the oxyalkylenes used, as long as they are commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., examples of the oxyalkylenes to be addition-polymerized include ethylene, propylene, butylene, etc., and one or more of these are preferred. The average number of moles of oxyalkylene added is preferably 5 to 40, more preferably 8 to 30. Specific examples of component (D) include polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, and more specifically, from the viewpoint of penetration feeling and the like, polyoxyethylene (26) glyceryl ether, polyoxypropylene (9) diglyceryl ether, and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3BO) (8EO) (5PO) are preferred. Commercially available products that can be used include polyoxyethylene (26) glyceryl ethers such as LIPONIC EG-1 (manufactured by LIPO CHEMICALS) and BRAWNON GL-26 (manufactured by Aoki Oil & Fat Industries Co., Ltd.), polyoxypropylene (9) diglyceryl ethers such as SY-DP9 (manufactured by Sakamoto Pharmaceutical Co., Ltd.), and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3BO)(8EO)(5PO) such as Wilbride S-753D (manufactured by NOF Corporation).

[0021] In the present invention, one or more types of component (D) can be appropriately selected and used as needed. Note that two or more types may be two types of polyoxyalkylene alkyl glucosides, two types of polyoxyalkylene glyceryl ethers, two types of polyoxyalkylene diglyceryl ethers, or a combination of a polyoxyalkylene alkyl glucoside and a polyoxyalkylene glyceryl ether, a combination of a polyoxyalkylene alkyl glucoside and a polyoxyalkylene diglyceryl ether, or a combination of a polyoxyalkylene glyceryl ether and a polyoxyalkylene diglyceryl ether.

[0022] The content of component (D) in the present invention is not particularly limited, but is preferably 0.5% or more, more preferably 1% or more, based on the total amount of the oil-in-water emulsion composition. It is also preferably 8% or less, more preferably 6% or less, and particularly preferably 4% or less. This range is preferred because it provides excellent non-stickiness and penetration.

[0023] In the present invention, the ratio (C) / {(C)+(D)} of the mass content of component (C) to the total mass content of components (C) and (D) is 0.4 to 0.9. If the ratio (C) / {(C)+(D)} is less than 0.4, satisfactory firmness, non-stickiness, and penetration are not obtained. If the ratio (C) / {(C)+(D)} is more than 0.9, satisfactory smooth spread, non-stickiness, and penetration are not obtained.

[0024] In addition to the above-mentioned essential components, the oil-in-water emulsion composition of the present invention contains aqueous components such as water, lower alcohols, etc. as components constituting the aqueous phase. Furthermore, components commonly used in cosmetics can be contained as needed within quantitative and qualitative ranges that do not impair the effects of the present invention, such as surfactants, oils other than component (B) and component (C), powders, water-soluble polymers other than component (A), film-forming agents, antioxidants, pH adjusters, chelating agents, cosmetic ingredients, preservatives, fragrances, and refreshing agents.

[0025] The aqueous component is not particularly limited, so long as it is water or a water-soluble component commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc. Examples of water include purified water, hot spring water, ion-exchanged water, deep sea water, tap water, and steam-distilled water from plants, and one or more types may be appropriately selected and used as needed. Plant extracts such as aloe vera, witch hazel, hamamelis, cucumber, lemon, lavender, and rose water may also be used. Examples of water-soluble components include glycols such as propylene glycol, 1,3-butylene glycol, dipropylene glycol, and polyethylene glycol; glycerols such as glycerin, diglycerin, and polyglycerin; sugar alcohols such as sorbitol, maltitol, and glucose; lower alcohols such as ethanol; and component (D).

[0026] In the oil-in-water emulsion composition of the present invention, from the viewpoint of penetration sensation, etc., the proportion of aqueous components in the oil-in-water emulsion composition is preferably 60% or more, more preferably 70% or more, and even more preferably 75% or more. The water content in the present invention is not particularly limited, but is preferably 40% or more, more preferably 45% or more, based on the total amount of the oil-in-water emulsion composition. The upper limit is preferably 80% or less, more preferably 70% or less. This range is preferred because it provides excellent penetration sensation and excellent stability over time.

[0027] The surfactant may be any surfactant commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., including nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. Among these, in the present invention, it is preferable to contain a nonionic surfactant from the viewpoint of stability over time. The content of the nonionic surfactant is not particularly limited, but is preferably 0.1 to 5%, more preferably 0.1 to 3%, and even more preferably 0.5 to 3%, based on the total amount of the oil-in-water emulsion composition. This range is preferable because it provides superior usability, such as stickiness and penetration, and superior stability over time.

[0028] As the oil, any oil commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc. can be used without any particular restrictions, and solid oils, liquid oils, volatile oils, etc. other than component (B) can be used regardless of their origin, such as animal oil, vegetable oil, synthetic oil, etc. Furthermore, hydrocarbons, fats and oils, ester oils, fatty acids, higher alcohols, fluorine-based oils, etc. can be used, and one or more selected from these can be contained as necessary.

[0029] The method for producing the oil-in-water emulsion composition of the present invention is not particularly limited, and the composition can be produced by a commonly known method, specifically, a dispersion emulsification method, a phase inversion emulsification method, a phase inversion temperature emulsification method, etc. Any dispersion / emulsification equipment such as a general dispersion equipment may be used for the production. For example, an aqueous phase heated to 70 to 80°C is added to an oil phase in which components (B) and (C) have been heated and dissolved at 70 to 80°C, and the mixture is emulsified and mixed using a dispersion mixer. After cooling, components (A) and (D) are added, mixed, and dissolved to obtain an oil-in-water emulsion composition.

[0030] The oil-in-water emulsion composition of the present invention can be in various forms, such as liquid, gel, emulsion, cream, semi-solid, or solid, and is preferably in an emulsion to cream form in order to obtain the effects of the present invention. Here, emulsion to cream means a composition having a viscosity of 70,000 mPa·s or less, preferably 50,000 mPa·s or less, and more preferably 45,000 mPa·s or less, as measured at 25°C using a Brookfield rotational viscometer.

[0031] The oil-in-water emulsion composition of the present invention can be used as cosmetics for various applications. Examples of such cosmetics include lotions, emulsions, creams, beauty serums, massage cosmetics, pack cosmetics, hand creams, body lotions, body creams, makeup cosmetics, makeup base cosmetics, eye creams, and sunscreens. In terms of being able to actually feel the effects, skin care cosmetics are preferred, and in particular, emulsions, creams, beauty serums, massage cosmetics, hand creams, body creams, and the like are preferred in terms of optimally exerting the effects of the present invention.

[0032] The oil-in-water emulsion composition of the present invention can also be used as a topical skin preparation. Examples include topical liquid preparations, topical gel preparations, cream preparations, ointments, liniments, lotions, poultices, plasters, spray preparations, and aerosol preparations. The methods of use thereof can be the same as those for the above-mentioned cosmetics. [Example]

[0033] The effects of the present invention will be explained using the following examples and comparative examples, although the technical scope of the present invention is not limited to the following examples.

[0034] Examples 1 to 9 and Comparative Examples 1 to 6: Oil-in-water emulsion compositions Oil-in-water emulsion compositions having the compositions shown in Table 1 were produced by the following production method, and evaluated for (a) smooth spreadability, (b) richness, (c) firmness, (d) non-stickiness, and (e) penetration according to the following evaluation methods and criteria. The results are also shown in Table 1.

[0035] [Table 1]

[0036] Note 1: SUPER WHITE PROTOPET PETROLATUM (manufactured by Sonneborn) Note 2: Super Nucor H (purity 94%, manufactured by NOF Corporation) Note 3: Rice sterol ester (Tsukuno Rice Fine Chemicals Co., Ltd.) Note 4: Eldew CL-301 (manufactured by Ajinomoto Co., Inc.) Note 5: Pearleem 18 (manufactured by NOF Corporation)

[0037] (Manufacturing method) A: Dissolve ingredients (2) to (12) uniformly at 75°C. B: Dissolve ingredients (1), (13) to (15) uniformly at 75°C. C: Gradually add B to A and emulsify using a Despa mixer. D: C was cooled to room temperature to obtain an oil-in-water emulsion composition.

[0038] (Evaluation method) The oil-in-water emulsion compositions of Examples 1 to 9 and Comparative Examples 1 to 6 were subjected to the following sensory evaluation test. Ten expert panelists in their 20s to 40s, who had received sensory evaluation training and were capable of evaluating according to a set standard, were selected. The expert panelists applied 2 g of each sample to their forearms, and each sample was evaluated and scored on a 5-point absolute scale based on the smoothness of spread and richness during application, the firmness and non-stickiness after application, and the penetration feel. For each sample, the average score was calculated from the total scores of all panelists, and the score was evaluated according to the 4-point scale below.

[0039] (I: Smooth and spreadable) <Absolute evaluation criteria> (Rating): (Evaluation) 5 points: Feels smooth and spreadable 4 points: Slightly smooth and spreadable 3 points: Average 2 points: Not much smooth spreading 1 point: No smooth spreading feeling (B: Richness) <Absolute evaluation criteria> (Rating): (Evaluation) 5 points: Feels rich 4 points: Somewhat rich taste 3 points: Average 2 points: I don't feel it has much body. 1 point: Not rich in flavor (H: Firmness) <Absolute evaluation criteria> (Rating): (Evaluation) 5 points: I feel a sense of firmness 4 points: I feel a slight firmness 3 points: Average 2 points: I don't feel much firmness. 1 point: No firmness (2: Non-stickiness) <Absolute evaluation criteria> (Rating): (Evaluation) 5 points: No stickiness 4 points: Almost no stickiness 3 points: Slightly sticky 2 points: Sticky 1 point: Very sticky (E: Permeability) <Absolute evaluation criteria> (Rating): (Evaluation) 5 points: I feel like it penetrates into the skin. 4 points: I feel like it penetrates into the skin. 3 points: Average 2 points: I don't feel like it penetrates into the skin very much. 1 point: I don't feel like it penetrates into the skin.

[0040] <4-level evaluation criteria> (Judgment): (Average score) ◎: Over 4.5 points: Very good ○: Over 3.5 points, 4.5 points or less: Good △: Over 1.5 points and 3.5 points or less: Slightly poor × :1.5 points or less :Poor

[0041] As is clear from the results in Table 1, the oil-in-water emulsion compositions of Examples 1 to 9 of the present invention were excellent in smooth spreadability, richness, firmness, non-stickiness, and penetration. On the other hand, Comparative Example 1, which did not contain component (B), and Comparative Example 2, which contained less than 3% of component (B), were unsatisfactory in terms of richness during application and firmness after application. In contrast, Comparative Example 3, which contained more than 15% of component (B), exhibited poor smooth spread during application, non-stickiness after application, and a poor penetration feel. Comparative Example 4, which used squalane instead of component (C), also exhibited unsatisfactory firmness after application. Furthermore, Comparative Example 5, in which the content of component (C) relative to the total amount of components (C) and (D) was more than 0.9, and Comparative Example 6, in which the content was less than 0.4, were unsatisfactory in terms of smooth spread during application, non-stickiness after application, and a poor penetration feel.

[0042] Example 10: Emulsion (Component) (%) 1. Heparinoid 2.0 2. Lipophilic glyceryl monostearate 0.3 3. Sorbitan monoisostearate 0.2 4. Polyoxyethylene sorbitan monooleate (20E.O.) 0.4 5. Stearic acid 0.2 6. Cetostearyl alcohol 0.5 7. Behenyl alcohol 0.1 8. Vaseline Note 1 3.0 9. Shea butter 1.0 10. Liquid Paraffin 4.0 11. Dimethicone (6CS) 2.0 12. Cetyl 2-ethylhexanoate 2.0 13. Hydrogenated polyisobutene Note 5 3.0 14. Remaining purified water 15. Acrylic acid / alkyl methacrylate copolymer 0.2 16. (PEG-240 / Decyltetradeceth-20 / HDI) Copolymer 0.02 17. Polyoxyethylene (26) glyceryl ether 2.0 18.1,3-Butylene glycol 10.0 19. Glycerin 5.0 20. Triethanolamine 0.6 21. Ethanol 5.0 22. Phenoxyethanol 0.5 23.Fragrance 0.1 24. L-Theanine 0.1 25. N-acetyl-L-hydroxyproline 0.1 26. L-Serine 0.1

[0043] (Manufacturing method) A: Heat ingredients (2) to (13) to 75°C and dissolve. B: Heat and dissolve components (1), (14) to (20) at 75°C. C: Add B to A, mix, then cool to room temperature. D: Components (21) to (26) were added to C and mixed to obtain an emulsion.

[0044] The emulsion of Example 10 had smooth spreadability and richness during application, and excellent firmness, non-stickiness, and penetration after application. The content of component (C) relative to the total amount of components (C) and (D) was 0.6.

[0045] Example 11: Cream (Component) (%) 1. Heparinoid 2.0 2. Lipophilic glyceryl monostearate 0.6 3. Sorbitan monoisostearate 0.5 4. Polyoxyethylene sorbitan monooleate (20E.O.) 0.5 5. Stearic acid 0.8 6. Cetostearyl alcohol 3.0 7. Behenyl Alcohol 2.0 8. Vaseline Note 1 5.0 9. Hydrogenated Palm Oil Note 2 3.0 10. Macadamia Nut Fatty Acid Phytosteryl Note 6 2.0 11. Liquid Paraffin 5.0 12. Triethylhexanoin 5.0 13. Hydrogenated polyisobutene (average molecular weight: 1500) 5.0 14. Remaining purified water 15. Acrylic acid / alkyl methacrylate copolymer 0.1 16. (Sodium acrylate / sodium acryloyldimethyltaurate) copolymer 0.3 17. Polyoxypropylene (9) diglyceryl ether 5.0 18.1,3-Butylene glycol 14.0 19. Glycerin 7.0 20. Diglycerin 2.0 21. Triethanolamine 0.9 22. Methylparaben 0.1 Note 6: PLANDOOL-MAS (manufactured by Nippon Fine Chemical Co., Ltd.)

[0046] (Manufacturing method) A: Heat ingredients (2) to (13) to 75°C and dissolve. B: Heat and dissolve components (1), (14) to (21) at 75°C. C: Add B to A, mix, then cool to room temperature. D: Component (22) was added to C and mixed to obtain a cream.

[0047] The cream of Example 11 had smooth spreadability and richness during application, firmness and non-stickiness after application, and excellent penetration. The content of component (C) relative to the total amount of components (C) and (D) was 0.5.

[0048] Example 12: Hand Cream (Component) (%) 1. Heparinoid 2.0 2. Lipophilic glyceryl monostearate 0.4 3. Sorbitan monoisostearate 0.3 4. Polyoxyethylene sorbitan monooleate (20E.O.) 0.2 5. Stearic acid 0.5 6. Cetostearyl alcohol 0.8 7. Behenyl alcohol 0.3 8. Vaseline Note 1 6.0 9. Phytosteryl Oleate Note 3 2.0 10. Macadamia Nut Fatty Acid Phytosteryl Note 6 1.0 11. Dimethicone (100CS) 0.4 12. Pentaerythritol tetra 2-ethylhexanoate 2.0 13. Hydrogenated polyisobutene (average molecular weight: 2000) 2.0 14. Remaining purified water 15. Acrylic acid / alkyl methacrylate copolymer 0.5 16. Polyoxybutylene Polyoxyethylene Polyoxypropylene Glyceryl ether (3BO) (8EO) (5PO) 3.0 17.1,3-Butylene glycol 6.5 18. Glycerin 7.0 19. Diglycerin 3.0 20. Triethanolamine 0.7 21. Phenoxyethanol 0.5 22. Ethanol 8.0 23.Fragrance 0.2

[0049] (Manufacturing method) A: Heat ingredients (2) to (13) to 75°C and dissolve. B: Heat and dissolve components (1), (14) to (20) at 75°C. C: Add B to A, mix, then cool to room temperature. D: Components (21) to (23) were added to C and mixed to obtain a hand cream.

[0050] The hand cream of Example 12 had excellent smooth spreadability and richness during application, firmness and non-stickiness after application, and excellent penetration. The content of component (C) relative to the total amount of components (C) and (D) was 0.4.

[0051] Example 13: Cosmetic serum (Component) (%) 1. Heparinoid 2.0 2. Lipophilic glyceryl monostearate 0.2 3. Sorbitan monoisostearate 0.1 4. Polyoxyethylene sorbitan monooleate (20E.O.) 0.1 5. Stearic acid 0.4 6. Cetostearyl alcohol 0.2 7. Behenyl alcohol 0.2 8. Vaseline Note 1 2.0 9. Hydrogenated Palm Oil Note 2 1.0 10. Macadamia Nut Fatty Acid Phytosteryl Note 6 0.5 11. Dimethicone (100CS) 1.0 12. Triethylhexanoin 2.0 13. Hydrogenated polyisobutene Note 5 1.6 14. Remaining purified water 15. Acrylic acid / alkyl methacrylate copolymer 0.5 16. Hydroxyethylcellulose 0.1 17. Polyoxybutylene Polyoxyethylene Polyoxypropylene Glyceryl ether (3BO) (8EO) (5PO) 2.4 18. 1,3-Butylene Glycol 5.0 19. Glycerin 7.0 20. Polyglycerin-3 2.0 21. Triethanolamine 0.5 22. Ethanol 10.0 23. Phenoxyethanol 0.5 24.Fragrance 0.2

[0052] (Manufacturing method) A: Heat ingredients (2) to (13) to 75°C and dissolve. B: Heat and dissolve components (1), (14) to (21) at 75°C. C: Add B to A, mix, then cool to room temperature. D: Components (22) to (24) were added to C and mixed to obtain a beauty serum.

[0053] The serum of Example 13 had smooth spreadability and richness during application, and excellent firmness, non-stickiness, and penetration after application. The content of component (C) relative to the total amount of components (C) and (D) was 0.4.

Claims

1. An oil-in-water emulsion composition comprising the following components (A) to (D), wherein the ratio of the mass content of component (C) to the total mass content of components (C) and (D) is (C) / {(C)+(D)} 0.4 to 0.9: (A) Heparinoids (B) 3 to 15% by mass of an oil agent that is in a paste form at 25°C (C) Hydrogenated polyisobutene (D) one or more selected from polyoxyalkylene alkyl glucoside, polyoxyalkylene glyceryl ether, and polyoxyalkylene diglyceryl ether

2. 2. The oil-in-water emulsion composition according to claim 1, wherein the content of the component (C) is 1 to 15% by mass, and the content of the component (D) is 0.5 to 8% by mass.

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