Oily gel

Abstract

To provide an oil-based gel formulation that has a good use feeling and can be held effectively on fingertips, wherein, the oil-based gel should preferably prevent the occurrence of phase separation of liquid components.SOLUTION: A oil-based gel includes a first fatty acid dextrin and a second fatty acid dextrin. The first fatty acid dextrin is a fatty acid dextrin with its constituent fatty acids including both straight-chain and branched-chain fatty acids. The second fatty acid dextrin is a fatty acid dextrin with its constituent fatty acids consisting of only straight-chain fatty acids. The first fatty acid dextrin should be preferably selected from dextrin palmitate / ethylhexanoate, dextrin palmitate / hexyldecanoate and the like. The second fatty acid dextrin should be preferably selected from dextrin palmitate, dextrin myristate, dextrin stearate and the like.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an oily gel. In the present disclosure, the term "oily gel" can be rephrased as, for example, an "oily gel composition." [Background technology]

[0002] The skin of the anal or buttocks is prone to roughness and rashes due to excessive wiping with paper after defecation, excessive washing with a shower toilet, irritation from feces or urine, or bacterial contamination.

[0003] Conventionally, oily gels have been used as medicines and cosmetics for skin diseases such as rough skin and rashes.

[0004] Generally, oily gels are prepared by gelling liquid oils such as liquid paraffin and medium-chain fatty acid triglycerides with gelling agents such as polyethylene wax and fatty acid dextrin.

[0005] Patent Document 1 discloses an ointment base comprising petrolatum, fatty acid dextrin, and solid oil, wherein the fatty acid constituting the fatty acid dextrin is a saturated fatty acid having 14 to 18 carbon atoms, the solid oil has a melting point of 40°C or higher, and the base contains 2 to 10 parts by weight of fatty acid dextrin and 3 to 34 parts by weight of fatty acid dextrin and solid oil in total per 100 parts by weight of petrolatum. Patent Document 2 discloses a semi-solid preparation containing a dextrin fatty acid ester, petrolatum, and polyethylene powder.

[0006] Patent Document 3 discloses an oily topical preparation containing a) at least one water-soluble or fat-soluble active ingredient, b) at least one selected from the group consisting of fatty acid dextrin and hydroxystearic acid, and c) an oily base. However, these documents do not disclose an oily gel containing multiple types of fatty acid dextrin. [Prior art documents] [Patent documents]

[0007] [Patent Document 1] Patent No. 6566574 [Patent Document 2] Japanese Patent Application Laid-Open No. 2003-128533 [Patent Document 3] Japanese Patent Application Laid-Open No. 2003-128521 Summary of the Invention [Problem to be solved by the invention]

[0008] An object of the present invention is to provide an oily gel that has a good feel when used and is easily retained on the fingertips. Preferably, a further object of the present invention is to provide an oily gel that is inhibited from causing syneresis of the liquid component. [Means for solving the problem]

[0009] As a result of extensive research to achieve the above object, the present inventors have found that an oily gel that has a good feel when used and is retained on the fingertips can be obtained by combining multiple types of fatty acid dextrins as a gelling agent.

[0010] That is, the present invention relates to the following inventions. [1] An oily gel containing a first fatty acid dextrin and a second fatty acid dextrin, An oily gel preparation characterized in that the first fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids include straight-chain fatty acids and branched fatty acids, and the second fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids are only straight-chain fatty acids. [2] The oily gel according to [1], further comprising a liquid oil. [3] The oily gel according to [1] or [2], further comprising a semi-solid oil. [4] The oily gel preparation according to any one of [1] to [3], wherein the first fatty acid dextrin is one or two selected from the group consisting of (palmitic acid / ethylhexanoic acid) dextrin and (palmitic acid / hexyldecanoic acid) dextrin. [5] The oily gel preparation according to any one of [1] to [4], wherein the second fatty acid dextrin is one or more selected from the group consisting of dextrin palmitate, dextrin myristate, and dextrin stearate. [6] The oily gel preparation according to any one of [1] to [5], wherein the mass ratio of the first fatty acid dextrin to the second fatty acid dextrin is 0.1 to 20. [7] The oily gel according to any one of [1] to [6], wherein the content of the first fatty acid dextrin is 1 to 10% by mass, and the content of the second fatty acid dextrin is 0.5 to 6% by mass. [8] The oily gel according to any one of [1] to [7], wherein the total amount of the first fatty acid dextrin and the second fatty acid dextrin is 1.5 to 15% by mass based on the total amount of the oily gel. [9] The oily gel according to any one of [2] to [8], wherein the liquid oil is one or more selected from the group consisting of isostearic acid, isostearyl alcohol, medium-chain fatty acid triglyceride, octyldodecyl myristate, triethylhexanoin, squalane, and liquid paraffin.

[10] The oily gel preparation according to any one of [2] to [9], wherein the content of the liquid oil is 60 to 96.5 mass %.

[11] The oily gel preparation according to any one of [3] to

[10] , wherein the content of the semi-solid oil is 0.5 to 20% by mass.

[12] The oily gel formulation according to any one of [1] to

[11] , further comprising an active ingredient.

[13] The oily gel preparation according to any one of [1] to

[12] , which is an agent for improving the feeling of use.

[14] The oily gel preparation according to any one of [1] to

[12] , which is an agent for improving hold on fingertips.

[15] The oily gel preparation according to any one of [1] to

[12] , which is an agent for inhibiting syneresis of a liquid component.

[0011] The oily gel of the present invention is preferably an oily gel prepared by dissolving various fatty acid dextrins in liquid oil, and further dissolving semi-solid oil and / or solid oil in a mixture of various fatty acid dextrins and liquid oil as needed, followed by cooling. [Effects of the Invention]

[0012] The present invention can provide an oily gel that has a good feel when used and is easily retained on the fingertips.More preferably, the present invention can provide an oily gel in which syneresis of the liquid component is inhibited. DETAILED DESCRIPTION OF THE INVENTION

[0013] The present invention includes a linear / branched fatty acid dextrin and an oily gel containing the linear fatty acid dextrin.

[0014] Fatty acid dextrin In the present invention, fatty acid dextrin refers to, for example, an ester in which a fatty acid is esterified to a hydroxyl group of dextrin. The oily gel of the present invention contains linear / branched fatty acid dextrin and linear fatty acid dextrin. The oily gel of the present invention can be used to improve the feel of use, to improve retention on fingertips, and / or to inhibit syneresis of liquid ingredients.

[0015] Linear / branched fatty acid dextrin (first fatty acid dextrin) In the present invention, the linear / branched fatty acid dextrin refers to a fatty acid dextrin whose constituent fatty acids include linear fatty acids and branched fatty acids. Among the constituent fatty acids of the linear / branched fatty acid dextrin of the present invention, the linear fatty acids are not particularly limited as long as they are linear fatty acids, but for example, fatty acids having 22 or less, 18 or less, or 16 or less carbon atoms are preferred, and the lower limit of the carbon number may be 4, 6, 8, 10, 12, 14, or 15. Specifically, the carbon number may be 4 to 22, 6 to 22, 8 to 22, 10 to 22, 12 to 22, 14 to 22, 15 to 22, 4 to 18, 6 to 18, 8 to 18, 10 to 18, 12 to 18, 14 to 18, 15 to 18, 4 to 16, 6 to 16, 8 to 16, 10 to 16, 12 to 16, 14 to 16, or 15 to 16, and among these, a straight-chain fatty acid having 16 carbon atoms (palmitic acid) is particularly preferred. Of the constituent fatty acids of the linear / branched fatty acid dextrin of the present invention, the branched fatty acid is not particularly limited as long as it is a branched fatty acid, but for example, a fatty acid having 22 or less, 18 or less, or 16 or less carbon atoms is preferred, and the lower limit of the carbon number may be 4, 6, or 8. Specifically, the number of carbon atoms may be 4 to 22, 6 to 22, 8 to 22, 4 to 18, 6 to 18, 8 to 18, 4 to 16, 6 to 16, or 8 to 16, and among these, a branched fatty acid having 8 carbon atoms (ethylhexanoic acid) or a branched fatty acid having 16 carbon atoms (hexyldecanoic acid) is particularly preferred. As the linear / branched fatty acid dextrin of the present invention, for example, (palmitic acid / ethylhexanoic acid) dextrin or (palmitic acid / hexyldecanoic acid) dextrin is preferred, and (palmitic acid / ethylhexanoic acid) dextrin is more preferred from the viewpoint of further improving the feeling during use. These linear / branched fatty acid dextrins may be used alone or in combination of two or more types. In the present disclosure, "linear / branched fatty acid dextrin" can be rephrased as, for example, "first fatty acid dextrin."

[0016] Linear fatty acid dextrin (second fatty acid dextrin) In the present invention, the linear fatty acid dextrin refers to, for example, a fatty acid dextrin whose constituent fatty acids are linear fatty acids only. The linear fatty acid is not particularly limited as long as it is a linear fatty acid, but for example, fatty acids having 22 or less, 18 or less, or 16 or less carbon atoms are preferred, and the lower limit of the carbon number may be 4, 6, 8, 10, 12, 14, or 15. Specifically, the carbon number may be 4 to 22, 6 to 22, 8 to 22, 10 to 22, 12 to 22, 14 to 22, 15 to 22, 4 to 18, 6 to 18, 8 to 18, 10 to 18, 12 to 18, 14 to 18, 15 to 18, 4 to 16, 6 to 16, 8 to 16, 10 to 16, 12 to 16, 14 to 16, or 15 to 16. Among these, a straight-chain fatty acid having 18 carbon atoms (stearic acid), a straight-chain fatty acid having 16 carbon atoms (palmitic acid), or a straight-chain fatty acid having 14 carbon atoms (myristic acid) is particularly preferred. Preferred examples of the straight-chain fatty acid dextrin of the present invention include dextrin palmitate, dextrin myristate, and dextrin stearate, with dextrin palmitate being more preferred in terms of the strength of the gel that can be formed. These straight-chain fatty acid dextrins may be used alone or in combination of two or more. In the present disclosure, "straight-chain fatty acid dextrin" can be rephrased as, for example, "second fatty acid dextrin."

[0017] In the present disclosure, % refers to "% by mass" unless otherwise specified. The content of the linear / branched fatty acid dextrin in the oily gel is not particularly limited, but is preferably 0.1 to 20% by mass, more preferably 1 to 15% by mass, 1 to 10% by mass, or even more preferably 3 to 10% by mass. The content of the linear fatty acid dextrin of the present invention in the oily gel is preferably 0.05 to 15% by mass, more preferably 0.1 to 10% by mass, and even more preferably 0.5 to 6% by mass or even even more preferably 0.5 to 5% by mass. The total content of each fatty acid dextrin is not particularly limited, but is preferably 0.15 to 35% by mass, more preferably 1 to 25% by mass, 1.5 to 15% by mass, or even more preferably 3 to 20% by mass, and even more preferably 3.5 to 15% by mass, based on the total mass of the oily gel. When the linear / branched fatty acid dextrin is (palmitic acid / ethylhexanoic acid) dextrin, the content is particularly preferably 1 to 10% by mass, and when it is (palmitic acid / hexyldecanoic acid) dextrin, the content is particularly preferably 3 to 7% by mass. By keeping the content within the above ranges, syneresis of the liquid component can be further suppressed and / or a better feel can be achieved.

[0018] The mass ratio of the linear / branched fatty acid dextrin to the linear fatty acid dextrin in the present invention is preferably, for example, 0.01 or more, 0.05 or more, 0.1 or more, 0.15 or more, 0.17 or more, 0.2 or more, 0.4 or more, or 0.6 or more. A mass ratio of 0.17 or more is particularly preferred in that syneresis of the liquid component can be further suppressed. The mass ratio of the linear / branched fatty acid dextrin to the linear fatty acid dextrin in the present invention may be, for example, 20 or less, 18 or less, 16 or less, or 14 or less. Specifically, the mass ratio may be 0.01 to 20, 0.05 to 20, 0.1 to 20, 0.15 to 20, 0.17 to 14, 0.2 to 20, 0.4 to 16, or 0.6 to 14.

[0019] oily In the present invention, "oily" refers to, for example, a continuous phase of oil and substantially no water. Here, "substantially no water" means that no water is contained at all, or even if water is contained, the amount is so small that it does not affect the present invention. The content is, for example, preferably 10% by mass or less, more preferably 5% by mass or less, and particularly preferably less than 1% by mass.

[0020] Gel The gel in the present invention refers to, for example, a paste-like or gel-like substance, product, drug or preparation.

[0021] The oily gel of the present invention can further contain a liquid oil. In the present invention, liquid oil refers to, for example, an oil that is liquid at normal room temperature (1 to 30°C). The liquid oil used in the present invention may be either a polar oil or a non-polar oil. For example, it is preferable that the liquid oil is hydrophobic, provides an appropriate protective feeling to the skin, is non-irritating, and dissolves various fatty acid dextrins at 100°C or below. Furthermore, the liquid oil preferably has an appropriate polarity and molecular structure that does not inhibit the formation of a reticulated network, which is the mechanism by which fatty acid dextrins form an oily gel. By including a liquid oil in the gel, the oily gel of the present invention can have effects such as protecting affected areas and moisturizing effects, and can also have effects on preventing or improving skin diseases such as rough skin and rashes in the anal area, buttocks, etc. Specific examples of such liquid oils include isostearic acid, isostearyl alcohol, medium-chain fatty acid triglycerides, octyldodecyl myristate, triethylhexanoin, squalane, and liquid paraffin. Among these, isostearic acid and / or isostearyl alcohol are particularly preferred because they provide a more appropriate protective feeling upon application and / or form a gel with more appropriate strength. These liquid oils may be used alone or in combination of two or more.

[0022] The content of the liquid oil in the gel of the present invention is not particularly limited, but is preferably 50 to 99 mass %, more preferably 60 to 95 mass %, and particularly preferably 69 to 93 mass %.

[0023] The oily gel of the present invention may further contain a semi-solid oil. Semi-solid oil in the present invention refers to, for example, an oil that has intermediate properties between liquid and solid at normal room temperature (1 to 30°C). Any semi-solid oil can be used without particular limitation as long as it has the above properties, but preferred is one that has moderate viscosity and excellent applicability to the skin, etc. Examples of semi-solid oils include, but are not limited to, petrolatum (white petrolatum, yellow petrolatum, etc.), lanolin, gelling hydrocarbons, horse oil, etc. Among these, petrolatum or horse oil is preferred from the viewpoint of usability. Blending a semi-solid agent into the oily gel can further enhance the application sensation, improve adhesion to the skin, and achieve a higher moisturizing effect. These semi-solid oils may be used alone or in combination of two or more.

[0024] The content of the semi-solid oil in the gel of the present invention is, for example, preferably 0.1 to 30 mass %, more preferably 0.2 to 25 mass %, and particularly preferably 0.5 to 20 mass %.

[0025] The oily gel of the present invention may further contain a solid oil. The solid oil in the present invention refers to, for example, an oil that is solid at normal room temperature (1 to 30°C). By incorporating a solid oil, adhesion to the skin can be improved and a higher moisturizing effect can be obtained. These solid oils may be used alone or in combination of two or more types.

[0026] Specific examples of solid oils include, but are not limited to, waxes and higher alcohols. Examples of waxes include, but are not limited to, esters of higher fatty acids and higher alcohols, such as glycerin monostearate and tribehenin; similar neutral fats (monoglycerides, diglycerides, triglycerides, etc.); higher fatty acids, such as stearic acid and behenic acid; hydrocarbons, such as paraffin, montan wax, ozokerite, microcrystalline wax, and ceresin; vegetable waxes, such as carnauba wax and candelilla wax; and animal waxes, such as spermaceti, beeswax, white beeswax, shellac, and lanolin. Examples of higher alcohols include, but are not limited to, myristyl alcohol, cetyl alcohol (cetanol), stearyl alcohol, arachyl alcohol, cholesterol, phytosterol, behenyl alcohol, and lanolin alcohol. The content of the solid oil in the gel of the present invention is, for example, preferably 0 to 10% by mass, more preferably 0.1 to 10% by mass, and particularly preferably 0.1 to 1% by mass.

[0027] The oily gel of the present invention may further contain one or more active ingredients, such as a local anesthetic, anti-inflammatory agent, blood flow promoter, antipruritic / wound healing agent, vitamin preparation, sulfonamide, disinfectant, vasoconstrictor, antihistamine, antidiarrheal / intestinal regulator, etc. (more preferably, active ingredients that can be contained in topical preparations; for example, lidocaine, prednisolone acetate, allantoin, vitamin E acetate, etc.). In addition to the above ingredients, additives such as absorption enhancers, pH adjusters, preservatives, dispersants, humectants, stabilizers, antiseptics, thickeners, antifoaming agents (e.g., dimethylpolysiloxane), and fragrances may be appropriately blended as needed. These additives may be used alone or in combination of two or more. The gel of the present invention may or may not contain, for example, polyethylene powder. The gel of the present invention may or may not contain, for example, hydroxystearic acid. The content ratio of the active ingredient or additive to the entire oily gel is not particularly limited as long as it is within the range of the amount generally used in oily gel preparations.

[0028] The application sites of the oily gel of the present invention include the skin of the head, ears, nose, mouth, etc., the neck, arms (including joints, backs of hands, palms, etc.), chest, abdomen, anus, buttocks, vulva, feet (including joints, soles, etc.), etc., but are not particularly limited thereto. The oily gel of the present invention is preferably applied to the anus, buttocks, etc. That is, the oily gel of the present invention can be used for the treatment of skin diseases in the areas exemplified above (preferably the anal area, buttocks, etc.), but is not particularly limited thereto. The amount of the oily gel of the present invention to be used is preferably 3 to 20 mg per kg of body weight, and is applied to the application site once or in divided doses per day. The subjects of administration are preferably humans, but may also be pet animals such as dogs and cats, or livestock animals such as cows and pigs. Application of the oily gel of the present invention to patients with hemorrhoids is one of the preferred embodiments of the present invention. Furthermore, using the oily gel of the present invention in combination with a therapeutic drug for hemorrhoids (for example, a lidocaine-containing drug such as Borraginol (registered trademark) (manufactured by Amato Pharmaceutical Co., Ltd.)) is also one of the preferred embodiments of the present invention. The oily gel of the present invention has a small temperature-dependent variation in viscosity and hardness, and is therefore superior in terms of usability, such as excellent application feel over a wide temperature range, compared to oily ointments based on the same oily preparation, such as white petrolatum.

[0029] The feel of an oily gel in use, its retention on fingertips, or the suppression of syneresis of the liquid component can be confirmed, for example, by referring to the methods in the Examples described below. Regarding the feel of an oily gel in use, for example, when an appropriate amount (e.g., 0.3 g) of the oily gel is taken on the fingertips and spread on the buttocks, if the application feel (spreadability, stickiness) is not difficult to spread and there is no obvious stickiness, it can be determined that the feel of use is good. Regarding the retention of an oily gel in fingers, for example, with the palm facing up, an appropriate amount (e.g., 0.3 g) of the oily gel is taken on the fingertips (e.g., between the fingertips and the first joint), and the fingertips are turned (i.e., palm facing down). When the time it takes for the oily gel to drip and fall from the fingertips when the oily gel is facing down is 10 seconds or more, it can be determined that the oily gel is retained on the fingers. Regarding the occurrence of syneresis of liquid components, for example, an oily gel is filled into an ointment tube and extruded linearly onto a glass plate so that the sample is 0.5 cm wide and 10 cm long. The extruded sample is stored under conditions of 25°C / 60% RH and 30°C / 75% RH. After 4 weeks of storage, the width of the syneresis material that has occurred from the edge of the sample is measured using a digital caliper. If the maximum syneresis width around the sample is 3 mm or less in all cases, it can be determined that there is an inhibitory effect on syneresis.

[0030] The oily gel of the present invention preferably has excellent storage stability. Excellent storage stability means that the properties of the oily gel are maintained without significant syneresis due to the liquid components leaking out of the oily gel during storage. The degree of syneresis is not particularly limited, but it is preferable that, for example, when stored at 25°C or 30°C, significant syneresis does not occur even after 7 days or more, 10 days or more, 14 days or more, 17 days or more, 21 days or more, 1 month or more, 3 months or more, 6 months or more, or 1 year or more, and the state in which the liquid components are retained in the oily gel is maintained.

[0031] The oily gel of the present invention can be produced using the first fatty acid dextrin and the second fatty acid dextrin, by appropriately selecting a dispersion medium (base) and / or additives suitable for the oily gel, according to a standard method described in the Japanese Pharmacopoeia, etc. Furthermore, examples of the method for producing the oily gel of the present invention include a method comprising the steps of dissolving each fatty acid dextrin in liquid oil to prepare an oily composition, melting a semi-solid oil, and mixing the oily composition with the semi-solid oil. The semi-solid oil may be added directly to the prepared oily composition for dissolution and / or mixing. In the method for producing the oily gel of the present invention, the prepared drug solution can be removed from the preparation tank before or after the step of cooling the drug solution.

[0032] More specifically, each fatty acid dextrin is added to liquid oil before heating and uniformly dispersed, and then heated to completely dissolve each fatty acid dextrin to prepare an oily composition. Separately melted semi-solid oil is added to the oily composition and mixed while stirring with a propeller mixer. Next, the mixture is cooled in a water bath while stirring with a propeller mixer to produce an oily gel. That is, the present invention encompasses oily gels obtained by the above method or oily gels obtained by dissolving each fatty acid dextrin in liquid oil (and semi-solid oil). [Example]

[0033] The present invention will be specifically explained in the examples, but the present invention is not limited to these examples.

[0034] (Examples 1 to 10, Comparative Examples 1 to 3) Oily gels were prepared according to the formulations listed in Table 1 using the following process. First, each fatty acid dextrin was added to liquid oil at room temperature and uniformly dispersed, followed by heating to 85-95°C to prepare an oily composition in which each fatty acid dextrin was dissolved. Separately, semi-solid oil was heated to 80-90°C to melt. The oily composition and the melted semi-solid oil were mixed and stirred at 300 rpm for 5 minutes using a propeller mixer (Tokyo Rikagaku Kikai Co., Ltd., propeller diameter 60 mm). Next, the mixture was placed in a water bath and cooled to a temperature of 60°C or below while stirring at 200 rpm using a propeller mixer, to prepare an oily gel.

[0035] raw material (First fatty acid dextrin) (Palmitic acid / ethylhexanoic acid) dextrin, manufactured by Chiba Flour Milling Co., Ltd., product name "Leopearl TT2" Dextrin (palmitate / hexyldecanoate) manufactured by Chiba Flour Mills Co., Ltd., product name "Leopearl WX" (Second fatty acid dextrin) Palmitic acid dextrin: Chiba Flour Milling Co., Ltd., product name "Leopearl KL2" (liquid oil) Isostearic acid: Manufactured by Kokyu Alcohol Kogyo Co., Ltd., product name "Isostearic acid EX" Isostearyl alcohol: Manufactured by Kokyu Alcohol Kogyo Co., Ltd., product name "Isostearyl Alcohol EX" Medium-chain fatty acid triglyceride: Kao Corporation, product name "Coconard MT" Octyldodecyl myristate, manufactured by Kao Corporation, product name "Excepearl OD-M" Liquid paraffin, manufactured by Kaneda Co., Ltd., product name "Hicol M-352"

[0036] The methods for evaluating the feel of the oily gel when used (applied), the retention on the fingertips, and the syneresis-inhibiting effect are described below. The evaluation results are shown in Table 1.

[0037] (Method for evaluating the feeling of use (application feeling)) The oily gel preparations of each Example and Comparative Example were filled into an ointment tube. Then, 0.3 g of the sample was taken on a fingertip and spread on the buttocks, and the application sensation (spreadability, stickiness) was evaluated (n=1). [Stretch] ◎: Very easy to spread ○: Easy to stretch △: Slightly difficult to spread ×: Hard to stretch [Sticky] ◎: No stickiness at all ○: Almost no stickiness △: Feels slightly sticky ×: Clearly sticky When neither spreadability nor stickiness was rated as "x," the product was judged to have a good feel when used.

[0038] (Method for evaluating fingertip holdability) The oily gel preparations of each Example and Comparative Example were filled into an ointment tube. Then, 0.3 g of the sample was placed on the fingertip (index finger) with the fingertip facing upward, and the fingertip was inverted so that the sample faced downward. The time until the sample dripped from the fingertip was measured. If the time until the sample dripped was 30 seconds or more, it was evaluated as ◎; if it was 20 seconds or more but less than 30 seconds, it was evaluated as ○; if it was 10 seconds or more but less than 20 seconds, it was evaluated as △; if it was less than 10 seconds, it was evaluated as × (n=1). If the evaluation did not fall under ×, it was determined that the sample had good retention on the fingertip.

[0039] (Method for evaluating syneresis inhibitory effect) The oily gel preparations of each Example and Comparative Example were filled into an ointment tube and extruded linearly onto a glass plate to a sample width of 0.5 cm and a total length of 10 cm. The extruded samples were stored under conditions of 25°C / 60% RH and 30°C / 75% RH, and the width of the syneresis occurring from the edge of the sample at the end of storage was measured using a digital caliper. A maximum syneresis width of 1 mm or less around the sample was evaluated as ◎, a maximum syneresis width of more than 1 mm but not more than 2 mm was evaluated as ○, a maximum syneresis width of more than 2 mm but not more than 3 mm was evaluated as △, and a maximum syneresis width of more than 3 mm was evaluated as ×. These evaluations were performed on samples stored for 4 weeks under each storage condition. If neither × was evaluated under the conditions of 25°C / 60% RH nor 30°C / 75% RH, syneresis was judged to have been suppressed.

[0040] (result) Regarding the feel when used (applied), Comparative Example 2, which contained only the first fatty acid dextrin at 20% of the fatty acid dextrins, received a rating of x for "spreadability" and x for "stickiness," indicating that a satisfactory feel when used was not obtained. On the other hand, Examples 1 to 10, which contained the first fatty acid dextrin and the second fatty acid dextrin, did not receive a rating of x for either "spreadability" or "stickiness," indicating that an oily gel preparation with a satisfactory feel when used was obtained.

[0041] Regarding fingertip retention, in Comparative Examples 1 and 3, which contained only the first fatty acid dextrin, the time it took for the sample to drip from the fingertip and come off was less than 10 seconds. On the other hand, in Examples 1 to 10, which contained both the first fatty acid dextrin and the second fatty acid dextrin, the time it took for the sample to drip from the fingertip was 20 seconds or more, demonstrating a clear improvement in fingertip retention.

[0042] Regarding the syneresis-suppressing effect, in Comparative Example 1, which used only the first fatty acid dextrin, the syneresis width exceeded 2 mm in both the samples stored for 4 weeks at 25°C / 60% RH and 30°C / 75% RH. In contrast, in Examples 1 to 8 and 10, which contained both the first and second fatty acid dextrins, the syneresis width was 2 mm or less in both the samples stored for 4 weeks at 25°C / 60% RH and 30°C / 75% RH, demonstrating that syneresis of the liquid component could be suppressed. These results demonstrate that when an oily gel contains both the first and second fatty acid dextrins and the mass ratio of the first fatty acid dextrin to the second fatty acid dextrin is 0.17 or greater, syneresis of the liquid component can be suppressed in addition to providing a good feel in use and improving fingertip retention.

[0043] From the above, the oily gel preparations of the examples were able to maintain a good feel when used (applied) and good retention on the fingertips.

[0044] [Table 1] [Industrial Applicability]

[0045] The present invention is useful as an oily gel in the fields of medicine and / or cosmetics.

Claims

1. An oily gel preparation containing a first fatty acid dextrin, a second fatty acid dextrin, and a semi-solid oil, The first fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids include straight-chain fatty acids and branched fatty acids, and the second fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids are only straight-chain fatty acids, An oily gel preparation characterized in that the content of the first fatty acid dextrin is 1 to 10% by mass and the content of the second fatty acid dextrin is 0.5 to 6% by mass.

2. An oily gel containing a first fatty acid dextrin, a second fatty acid dextrin, and a liquid oil, The first fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids include straight-chain fatty acids and branched fatty acids, and the second fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids are only straight-chain fatty acids, The content of the first fatty acid dextrin is 1 to 10% by mass, and the content of the second fatty acid dextrin is 0.5 to 6% by mass, An oily gel preparation characterized in that the content of liquid oil is 60 to 96.5 mass %.

3. The oily gel according to claim 1, further comprising a liquid oil.

4. The oily gel according to claim 2, further comprising a semi-solid oil.

5. An oily gel preparation according to any one of claims 1 to 4, wherein the first fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids include straight-chain fatty acids having 8 to 18 carbon atoms and branched fatty acids having 8 to 16 carbon atoms, and the second fatty acid dextrin is a fatty acid dextrin whose constituent fatty acids are only straight-chain fatty acids having 8 to 18 carbon atoms.

6. 5. The oily gel preparation according to claim 1, wherein the first fatty acid dextrin is one or two selected from the group consisting of (palmitic acid / ethylhexanoic acid) dextrin and (palmitic acid / hexyldecanoic acid) dextrin.

7. The oily gel preparation according to any one of claims 1 to 4, wherein the second fatty acid dextrin is one or more selected from the group consisting of dextrin palmitate, dextrin myristate, and dextrin stearate.

8. 5. The oily gel preparation according to claim 1, wherein the mass ratio of the first fatty acid dextrin to the second fatty acid dextrin is 0.1 to 20.

9. 5. The oily gel according to claim 1, wherein the total amount of the first fatty acid dextrin and the second fatty acid dextrin is 1.5 to 15% by mass based on the total mass of the oily gel.

10. The oily gel according to any one of claims 2 to 4, wherein the liquid oil is one or more selected from the group consisting of isostearic acid, isostearyl alcohol, medium-chain fatty acid triglyceride, octyldodecyl myristate, triethylhexanoin, squalane, and liquid paraffin.

11. The oily gel according to any one of claims 2 to 4, wherein the content of the liquid oil is 60 to 96.5% by mass.

12. 5. The oily gel according to claim 1, 3 or 4, wherein the content of the semi-solid oil is 0.5 to 20% by mass.

13. The oily gel according to any one of claims 1 to 4, further comprising an active ingredient.

14. An oily gel preparation according to any one of claims 1 to 4, which, when 0.3 g of the oily gel preparation is taken on the fingertips and spread on the buttocks, does not feel difficult to spread and does not feel obviously sticky.

15. The oily gel according to any one of claims 1 to 4, wherein when 0.3 g of the oily gel is placed on the fingertip with the palm facing up, the fingertip is turned over, and the oily gel is facing downward, it takes 10 seconds or more for the oily gel to drip from the fingertip.

16. An oily gel preparation according to any one of claims 1 to 4, wherein the oily gel preparation is filled into an ointment tube, and the extruded sample is extruded linearly onto a glass plate so that the sample has a width of 0.5 cm and a total length of 10 cm, and the extruded sample is stored under conditions of 25°C / 60% RH and 30°C / 75% RH, and when the width of the syneresis material emerging from the edge of the sample is measured with a digital caliper after 4 weeks of storage, the maximum width of the syneresis material around the sample is 3 mm or less in all cases.

17. An oily gel preparation according to any one of claims 1 to 4, for use at a dose of 3 to 20 mg per kg of body weight per day.

18. An oily gel preparation described in any one of claims 1 to 4, for use in skin diseases.

19. An oily gel preparation according to any one of claims 1 to 4, which is applied to the anal area or buttocks.

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