Lice repellent

Abstract

To provide a lice repellent that can be safely used for children and exhibits excellent lice repelling effect.SOLUTION: A lice repellent contains Icaridin as an active ingredient.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a lice repellent. [Background technology]

[0002] Lice such as body lice and head lice have been known to cause health problems such as intense itching due to blood-sucking caused by infesting and attaching to clothing and the human body, and further health problems such as skin inflammation caused by scratches caused by the itching.To prevent these health problems and to prevent the spread of the damage, preparations that are applied to the human body and clothing are known.

[0003] For example, Patent Documents 1 and 2 disclose sanitary pest repellents containing a predetermined content of DEET (N,N-diethyl-m-toluamide) as an active ingredient. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2013-237636 [Patent Document 2] Japanese Patent Application Laid-Open No. 2014-201581 Summary of the Invention [Problem to be solved by the invention]

[0005] However, DEET (N,N-diethyl-m-toluamide), the active ingredient in the sanitary pest repellents disclosed in Patent Documents 1 and 2, has restrictions on the number of times it can be used on children under the age of 12, who are prone to lice infestations. Therefore, it is extremely important to develop a lice repellent that can be used more safely on children.

[0006] Furthermore, unlike common blood-sucking pests such as mosquitoes, lice cannot fly by themselves and are parasitic from person to person through contact with hair, clothing, etc. Therefore, it has not necessarily been possible to say that repellents for common blood-sucking pests such as mosquitoes can be directly applied to lice.

[0007] The present invention has been made in view of the above problems, and has as its object to provide a lice repellent which can be used more safely on children and which has an excellent lice repellent effect.

[0008] That is, the present invention relates to the following. (1) A lice repellent containing icaridin as an active ingredient. (2) A lice repellent according to (1) containing an essential oil. (3) A lice repellent according to (1) or (2), which contains an alcohol having 2 to 6 carbon atoms. (4) The lice repellent according to any one of (1) to (3), wherein the content of the icaridin is 5.0 w / v to 18.0 w / v %. (5) The lice repellent according to any one of (1) to (4), wherein the lice are body lice or head lice. (6) A lice repellent according to any one of (1) to (5), which has a repellent effect lasting for 10 hours or more. [Effects of the Invention]

[0009] The lice repellent of the present invention can be used more safely on children and has an excellent lice repellent effect. DETAILED DESCRIPTION OF THE INVENTION

[0010] The lice repellent of the present invention will be described in detail below. However, the present invention is not intended to be limited to the configuration described below. In this specification, when a range is indicated by "to", it is assumed that the range includes both the upper and lower limits.

[0011] Icaridin used in the present invention is an active ingredient that exhibits a repellent effect against lice larvae and adults. Specifically, Icaridin is 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine, also known as picaridin.

[0012] The content of icaridin used in the present invention is preferably 3.0 w / v% to 30.0 w / v%, more preferably 4.0 w / v% to 20.0 w / v%, and most preferably 5.0 to 18.0 w / v%. If the content of icaridin is within this range, it can be used more safely on children and exhibits a more excellent repellent effect against lice such as body lice and head lice. In the present invention, the concentration notation of w / v% is the ratio of grams (g) per 100 mL.

[0013] In the present invention, essential oils can be used. Essential oils are used for fragrance, but also act as repellent effect-sustaining components that prolong the repellent effect of the active ingredient, icaridin. Such essential oils are volatile oils obtained from various plants by distillation methods such as steam distillation. The essential oil is preferably at least one selected from the group consisting of clove oil distilled from cloves, fennel oil distilled from fennel, and lemongrass oil distilled from lemongrass. In the present invention, clove oil, fennel oil, and lemongrass oil can be used alone or in a suitable mixture of two or three types.

[0014] The content of the essential oil used in the present invention is preferably 0.05 w / v% to 20.0 w / v%, and more preferably 0.1 w / v% to 10.0 w / v%, which provides a more effective repellent effect against lice such as body lice and head lice.

[0015] In the present invention, an alcohol having 2 to 6 carbon atoms, preferably an alcohol having 2 to 4 carbon atoms, may be contained. The alcohol having 2 to 6 carbon atoms acts as a solvent. Preferred examples of such an alcohol include ethanol, 1-propanol, 2-propanol, 1-butanol, ethylene glycol, propylene glycol, butylene glycol, 1,3-butylene glycol, diethylene glycol, and glycerin.

[0016] The content of the alcohol having 2 to 6 carbon atoms used in the present invention is preferably 1.0 w / v % to 90.0 w / v %, and more preferably 5.0 w / v % to 85.0 w / v %.

[0017] The lice repellent of the present invention may contain surfactants, antibacterial agents, fragrances, volatilization regulators, antioxidants, preservatives, water, and the like.

[0018] Examples of surfactants include ethers such as polyoxyethylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene alkylamino ethers, and polyoxyethylene hydrogenated castor oils; fatty acid esters such as polyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene glycerin fatty acid esters; nonionic surfactants such as polyoxyethylene styrenated phenol and polyalkalolamide of fatty acid; and anionic surfactants such as polyoxyethylene (POE) styrylphenyl ether sulfate, polyoxyethylene (POE) alkyl ether sulfate, and dodecylbenzene sulfate.

[0019] Examples of antibacterial agents include 3-methyl-4-isopropylphenol, ortho-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-mercaptobenzothiazole, 2-n-octyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, and the like.

[0020] Examples of the flavoring include fruit flavorings such as orange, grapefruit, berry, strawberry, peach, lychee, banana, melon, grape, muscat, apple, and pineapple.

[0021] Examples of the volatilization regulator include fatty acid esters such as glycerin fatty acid esters and isopropyl myristate, vegetable oils such as coconut oil, and liquid paraffin, with isopropyl myristate being preferred.The content of the volatilization regulator is preferably 1.0 w / v% to 10.0 w / v%, and more preferably 2.0 w / v% to 5.0 w / v%.

[0022] Examples of antioxidants include vitamin C (ascorbic acid), vitamin E (α-tocopherol), BHT (dibutylhydroxytoluene), BHA (dibutylhydroxyanisole), sorbic acid, potassium sorbate, sodium sulfite, and the like.

[0023] Examples of preservatives include parabens such as methyl parahydroxybenzoate, ethyl parahydroxybenzoate, normal propyl parahydroxybenzoate, isopropyl parahydroxybenzoate, normal butyl parahydroxybenzoate, and isobutyl parahydroxybenzoate.

[0024] Examples of water include purified water such as ion-exchanged water and reverse osmosis water, ordinary tap water, industrial water, and deep sea water.

[0025] In addition to the above ingredients, IR3535, p-menthane-3,8-diol, pH adjusters, buffers, pigments, etc. may also be added.

[0026] The lice repellent of the present invention can be produced by adding, mixing, or the like the various components described above by known methods.

[0027] The lice repellent of the present invention can be filled into various containers and made into various forms such as roll-on products, cream products, mist products, lotion products, spray products, aerosol products, stick products, and sheet-like products impregnated into nonwoven fabrics, etc., and of these, lotion products, spray products, and aerosol products are preferred.

[0028] The lice repellent of the present invention can be produced, for example, as a lotion product by filling it into a lotion container. As a spray product, it can be produced by filling it into a trigger-type or push-button type spray container. As an aerosol product, it can be produced by filling an aerosol concentrate into an aerosol container, and pressurizing and filling the aerosol container with a propellant, which may include, but is not limited to, liquefied gases such as dimethyl ether, liquefied petroleum gas (LPG), and hydrofluoroolefins, and compressed gases such as nitrogen gas, carbon dioxide gas, nitrous oxide, and compressed air, and then attaching a trigger-type or push-button type actuator.

[0029] The lice repellent of the present invention can repel lice by applying it to fabrics such as clothing or to hair. The amount of application is not particularly limited, but is preferably 0.1 mg / cm. 2 ~1000mg / cm 2 is preferably 1 mg / cm 2 ~100mg / cm 2 Such treatment with the lice repellent allows the repellent effect to last for about 1 to 15 hours, preferably for 10 hours or more.

[0030] The target of the lice repellent of the present invention is lice, such as body lice, head lice, and pubic lice. Of these, body lice and head lice are preferred. Such lice include nymphs and adults, and both male and female.

[0031] Next, the lice repellent of the present invention will be described in detail based on specific examples, but the present invention is not limited to these.

[0032] Example 1 At 25°C, 15.0 g of icaridin, 1.0 g of clove oil, and the remainder, ethanol, were added to a 200 mL Griffin beaker and stirred until homogenous to obtain 100 mL of a composition.

[0033] <Example 2> At 25°C, 15.0 g of icaridin, 1.0 g of clove oil, 1.0 g of fennel oil, 0.2 g of lemongrass oil, 3.0 g of isopropyl myristate, and the remainder, ethanol, were added to a 200 mL Griffin beaker and stirred until homogenous to obtain 100 mL of a composition.

[0034] Example 3 At 25°C, 15.0 g of icaridin, 1.0 g of clove oil, 1.0 g of fennel oil, 0.2 g of lemongrass oil, 3.0 g of isopropyl myristate, polyoxyethylene hydrogenated castor oil (also known as PEG-40 hydrogenated castor oil), and 40.0 g of ethanol were placed in a 200 mL Griffin beaker, and the remainder was added with purified water. The mixture was stirred until homogeneous, yielding 100 mL of a composition.

[0035] <Comparative Example 1> At 25°C, 15.0 g of DEET, 1.0 g of clove oil, and the remainder of the mixture, ethanol, were added to a 200 mL Griffin beaker and stirred until homogenous to obtain 100 mL of a composition.

[0036] Using the compositions obtained in Examples 1 to 3 and Comparative Example 1, a test was carried out on the repellent effect against adult lice.

[0037] [Adult louse repellent test] The compositions obtained in Examples 1 to 3 and Comparative Example 1 were placed in an open disk-shaped Petri dish with a diameter of 9 cm and covered with filter paper at a concentration of 10 mg / cm. 2The cloth was placed on the outside of a petri dish, and 20 body lice (10 males and 10 females) were placed on either side of the center. After a specified time, if there were no body lice on the cloth, it was considered to be repellent. The number of lice was counted and the repellency rate was calculated using Equation 1. Repellency rate (%) = (number of insects not present on the cloth / 20) × 100 (Equation 1) The repellency rate in a control test in which the same test was conducted without impregnating the cotton cloth with the composition obtained in each Example and Comparative Example was used as a correction coefficient, and the above repellency rate in each Example and Comparative Example was multiplied by this coefficient to calculate the corrected repellency rate.

[0038] The results are shown in Table 1.

[0039] [Table 1]

[0040] As shown in Table 1, it was found that Examples 1 to 3, in which the active ingredient was icaridin, exhibited a superior repellent effect against adult lice after 12 hours compared to Comparative Example 1, in which the active ingredient was DEET.

Claims

1. The active ingredient is icaridin, Polyoxyethylene hydrogenated castor oil, Essential oils and Contains A lice repellent wherein the essential oil is clove oil.

2. 2. The lice repellent according to claim 1, which is for treating hair.

3. The amount of treatment on the hair is 0.1 to 10 mg / cm ２ 3. The lice repellent according to claim 2, wherein

4. The active ingredient is icaridin, Essential oils and Alcohols with 2 to 6 carbon atoms Contains The essential oils include clove oil, fennel oil, and lemongrass oil.

5. Isopropyl myristate, Polyoxyethylene hydrogenated castor oil, Purified water and The lice repellent according to claim 4, which contains

6. 6. The lice repellent according to claim 1, wherein the content of icaridin is 5.0 w / v to 18.0 w / v %.

7. The lice repellent according to any one of claims 1 to 6, wherein the lice are body lice or head lice.

8. The lice repellent according to any one of claims 1 to 7, wherein the repellent effect lasts for 10 hours or more.

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