Foaming skin topical preparation kit

Abstract

To provide a kit for obtaining a foaming external preparation for skin which improves the skin condition and has a good feeling when used. [Solution] The kit for obtaining a foaming topical skin preparation of the present invention is a kit for obtaining a foaming topical skin preparation obtained by mixing an acidic substance, a carbon dioxide gas generating substance that reacts with the acidic substance to generate carbon dioxide gas, a thickener, and water, and is characterized by the fact that two or more types of thickeners are combined and formulated.

Description

[Technical Field]

[0001] The present invention relates to a kit for obtaining a foaming external skin preparation. [Background technology]

[0002] Conventionally, gel-type foaming skin preparations for external use have been proposed for cosmetic purposes, which are prepared by mixing a carbonate and an acid in the presence of water and a thickener to generate carbon dioxide gas (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Patent No. 4659980 Summary of the Invention [Problem to be solved by the invention]

[0004] However, there has been insufficient research into the improvement of skin condition, such as increasing the moisture content of the skin, reducing the amount of moisture evaporation, and improving skin elasticity, as well as into usability, stability, and feel when used, and even less research has been done into achieving both excellent improvement in skin condition and a good feel when used.

[0005] In the present invention, various investigations were carried out to obtain a foaming skin topical preparation that improves skin condition and has a good feel when used. As a result, the inventors discovered that the above problems can be solved by blending two or more types of thickeners in combination, and thus completed the present invention. [Means for solving the problem]

[0006] The present invention provides a kit for obtaining a foamable topical skin preparation by mixing an acidic substance, a carbon dioxide gas generating substance that reacts with the acidic substance to generate carbon dioxide gas, a thickener, and water, wherein the kit contains two or more types of thickeners and has any one of the following configurations (1) to (3). (1) A solid composition (A) containing an acidic substance and a composition (B) containing water, a thickener, and a carbon dioxide-generating substance. (2) A solid composition (C) containing an acidic substance and a carbon dioxide generating substance, and a composition (D) containing water and a thickener. (3) A solid composition (E) containing a carbon dioxide generating substance and a composition (F) containing water, a thickener, and an acidic substance. (However, this does not include thickeners (B), (D), and (F) that are the following combinations: a combination of sodium alginate and xanthan gum, cellulose gum, hydroxypropyl methylcellulose, carbomer, polyvinyl alcohol, or bentonite; a combination of xanthan gum and cellulose gum, hydroxypropyl methylcellulose, or bentonite; or a combination of cellulose gum and hydroxypropyl methylcellulose or carbomer.)

[0007] The present invention also provides the kit according to claim 1, characterized in that one or both of the compositions constituting the kit of (1) to (3) above further contains a polyhydric alcohol.

[0008] The present invention also provides a kit for obtaining the foamable topical skin preparation according to claim 1 or 2, characterized in that, among the kits (1) to (3), the solid compositions ((A), (C), and (E)) are in powder form, and the compositions containing water and a thickener ((B), (D), and (F)) are in gel form.

[0009] The present invention also provides a kit for obtaining a foaming topical skin preparation, characterized in that the thickeners used in the kits (1) to (3) above are two or more selected from natural polysaccharides and / or cellulose-based thickeners. [Effects of the Invention]

[0010] According to the present invention, by combining and formulating two or more types of thickeners, it is possible to provide a kit for obtaining a foaming topical skin preparation that has the effects of increasing the moisture content of the skin, reducing the amount of moisture lost, improving skin elasticity, and the like, thereby improving skin condition, and that is excellent in usability (e.g., ease of mixing and application), safety, and stability, and that provides a pleasant feel when used. [Brief explanation of the drawings]

[0011] [Figure 1] FIG. 1 shows the results of measuring the moisture content of the stratum corneum in the comparative example and the example. [Figure 2] FIG. 2 shows the results of measuring the amount of water evaporation in the comparative example and the example. [Figure 3] FIG. 3 shows the results of elasticity measurements for the comparative example and the example. DETAILED DESCRIPTION OF THE INVENTION

[0012] Hereinafter, a kit for obtaining the foamable external skin preparation of the present invention (hereinafter also referred to as "kit") will be described based on its preferred embodiments.

[0013] The kit of the present invention has any one of the following configurations (1) to (3). (1) A solid composition (A) containing an acidic substance and a composition (B) containing water, a thickener, and a carbon dioxide-generating substance. (2) A solid composition (C) containing an acidic substance and a carbon dioxide generating substance, and a composition (D) containing water and a thickener. (3) A solid composition (E) containing a carbon dioxide generating substance and a composition (F) containing water, a thickener, and an acidic substance. In this specification, the solid composition (1) will also be referred to as (A), the aqueous composition (1) as (B), the solid composition (2) as (C), the aqueous composition (2) as (D), the solid composition (3) as (E), and the aqueous composition (3) as (F).

[0014] The foaming topical skin preparation obtained using the kit of the present invention can be used in any form, such as a cosmetic, a quasi-drug, or a pharmaceutical product. However, from the standpoint of effectiveness and usability, it is preferable to use it as a cosmetic or a quasi-drug (medicated cosmetic).

[0015] Furthermore, the foamable topical skin preparation obtained using the kit of the present invention can be applied externally to skin, including the scalp and hair, and can be used in various forms such as a pack, hair growth agent, facial cleanser, cleanser, lotion, emulsion, beauty gel, shampoo, conditioner, etc. When washed off, it is preferably used in a pack, facial cleanser, cleanser, shampoo, conditioner, etc.

[0016] First, the main components used in the kit for obtaining the foamable external skin preparation of the present invention will be described.

[0017] <Acidic substances> The acidic substance used in the present invention may be any inorganic or organic acid that can be used in general external preparations, and one or more of these may be used.

[0018] Examples of inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium acid hexametaphosphate, sodium acid pyrophosphate, potassium acid pyrophosphate, and sulfamic acid.

[0019] Examples of organic acids include straight-chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid, or salts thereof; dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, and terephthalic acid, or salts thereof; acidic amino acids such as glutamic acid and aspartic acid, or salts thereof; and oxyacids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-hydroxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, and gluconic acid, or salts thereof.

[0020] Of these, citric acid, ascorbic acid, malic acid and succinic acid are preferred from the viewpoints of safety and solubility in water.

[0021] The content of the acidic substance in (A), (C), and (F) of the present invention is preferably 0.01 to 30 parts by mass, more preferably 0.05 to 20 parts by mass, relative to 100 parts by mass of the total amount of the two agents in the corresponding kit. The amount of the topical skin preparation referred to in this specification may be the amount at the start of mixing the components of each kit.

[0022] The content of the acidic substance in (A) of the present invention is preferably 0.1% by mass or more and 90% by mass or less, and more preferably 0.5% by mass or more and 80% by mass or less. The content of the acidic substance in (C) of the present invention is preferably 0.01% by mass or more and 50% by mass or less, and more preferably 0.05% by mass or more and 40% by mass or less. Furthermore, the content of the acidic substance in (F) of the present invention is preferably 0.01% by mass or more and 30% by mass or less, and more preferably 0.05% by mass or more and 20% by mass or less.

[0023] <Carbon dioxide generating substances> The carbon dioxide gas generating substance used in the present invention may be any substance that reacts with the acidic substance to generate carbon dioxide.

[0024] Examples of carbon dioxide gas generating substances include carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, and sodium sesquicarbonate, and bicarbonates such as ammonium bicarbonate, potassium bicarbonate, sodium bicarbonate, lithium bicarbonate, cesium bicarbonate, magnesium bicarbonate, and calcium bicarbonate, and one or more of these may be used. Among these, bicarbonates are preferably used, and sodium bicarbonate is more preferred because it can achieve a moderate foaming power.

[0025] The content of the carbon dioxide gas generating substance in (B), (C), and (E) of the present invention is preferably 0.01 to 30 parts by mass, and more preferably 0.05 to 20 parts by mass, relative to 100 parts by mass of the total amount of the two agents in the corresponding kit.

[0026] The content of the carbon dioxide gas generating substance in (B) of the present invention is preferably 0.01% by mass or more and 30% by mass or less, and more preferably 0.05% by mass or more and 20% by mass or less. The content of the carbon dioxide gas generating substance in (C) of the present invention is preferably 0.01% by mass or more and 50% by mass or less, and more preferably 0.05% by mass or more and 40% by mass or less. The content of the carbon dioxide gas generating substance in (E) of the present invention is preferably 0.1% by mass or more and 90% by mass or less, and more preferably 0.5% by mass or more and 80% by mass or less.

[0027] <Thickener> One of the features of the kit for obtaining the foaming topical skin preparation of the present invention is that it contains a combination of two or more thickeners. Such thickeners are described in detail below. Examples of thickeners that can be used in the present invention include various types of thickeners that can be used in the fields of cosmetics and pharmaceuticals, such as natural polysaccharides, cellulose-based polymers, synthetic polymers, and clay minerals.

[0028] As used herein, a natural polysaccharide refers to a polysaccharide derived from an animal or plant source or from microbial fermentation that has not been subjected to processing where the purpose of the processing is to reduce the size of the sugar. Polysaccharides undergo slight size reduction during normal refining procedures. Such sugars are still natural. Only when a polysaccharide is subjected to size reduction techniques is it considered to be non-natural.

[0029] Specific examples include xanthan gum, succinoglycan, carrageenan, guar gum, locust bean gum, galactan, gum arabic, tragacanth gum, tamarind gum, agar, agarose, mannan, curdlan, alginic acid or its salts, gum arabic, pectin, quince seed, starch, Algae colloid, chondroitin sulfate or its salts, Examples include chitosan and derivatives thereof, nucleic acids or salts thereof, ribonucleic acids or salts thereof, water-soluble proteins such as casein, collagen, gelatin, albumin, fibroin, elastin, keratin, and sericin, mucopolysaccharides such as hyaluronic acid or salts thereof, and chondroitin sulfate. Among these, xanthan gum, carrageenan, tamarind gum, and alginic acid or salts thereof are preferred from the viewpoint of achieving both an excellent feel in use and an effect of improving skin condition.

[0030] The cellulose-based polymer used in the present invention is a polymer composed of units of cellulose or its derivatives. Specific examples include carboxymethyl cellulose or its salts, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sulfonated cellulose derivatives, etc. Among these, carboxymethyl cellulose or its salts, hydroxyethyl cellulose, and hydroxypropyl methyl cellulose are preferred from the viewpoint of achieving both excellent usability and skin condition improving effects.

[0031] The synthetic polymer used in the present invention is a polymer artificially synthesized using monomers as structural units. Specific examples include vinyl polymers such as carboxyvinyl polymer and polyvinyl alcohol, acrylic acid polymers such as acrylic acid / alkyl methacrylate copolymer, acrylates / alkyl acrylate crosspolymer and polyacrylic acid, acrylamide polymers such as polyacrylamide and polyalkylacrylamide / polyacrylamide copolymer, Pluronic, and (PEG-240 / decyltetradeceth-20 / HDI) copolymer.

[0032] The clay mineral used in the present invention refers to a substance generally known as the main component mineral that constitutes clay. Specific examples include laponite, bentonite, smectite kaolinite, and montmorillonite.

[0033] In the present invention, the combination of two or more of the above-mentioned thickeners is not particularly limited. However, from the viewpoint of improving the feeling in use and improving the skin condition, a combination of two or more selected from natural polysaccharides and / or cellulose-based polymers is preferred, and a combination of one or more natural polysaccharides and one or more cellulose-based polymers is more preferred.

[0034] Specific examples of preferred combinations are as follows: (i) Examples of combinations of two or more natural polysaccharides include a combination of sodium alginate and at least one selected from tamarind gum and carrageenan, a combination of tamarind gum and at least one selected from carrageenan and xanthan gum, and a combination of carrageenan and xanthan gum. (ii) Examples of combinations of two or more cellulose polymers include a combination of cellulose gum and at least one selected from hydroxyethyl cellulose and hydroxypropyl methylcellulose stearoxy ether, and a combination of hydroxyethyl cellulose and hydroxypropyl methylcellulose stearoxy ether. (iii) Examples of combinations of one or more natural polysaccharides and one or more cellulose-based polymers include a combination of sodium alginate and at least one selected from hydroxyethyl cellulose and hydroxypropyl methylcellulose stearoxy ether, a combination of tamarind gum and at least one selected from cellulose gum, hydroxyethyl cellulose, and hydroxypropyl methylcellulose stearoxy ether, a combination of carrageenan and at least one selected from cellulose gum, hydroxyethyl cellulose, and hydroxypropyl methylcellulose stearoxy ether, and a combination of xanthan gum and at least one selected from hydroxyethyl cellulose and hydroxypropyl methylcellulose stearoxy ether.

[0035] Among these, the more preferred combination is the combination (iii).

[0036] Among the more desirable combinations, the following combinations are particularly excellent in terms of their individual effects while simultaneously achieving an excellent feel and improving skin condition. In terms of increasing the moisture content of the stratum corneum,Combinations of carrageenan and hydroxyethyl cellulose, and xanthan gum and hydroxyethyl cellulose are particularly preferred, from the viewpoint of ease of mixing, a combination of carrageenan and hydroxypropyl methylcellulose stearoxy ether is particularly preferred, from the viewpoint of fineness of foam, a combination of carrageenan and cellulose gum is particularly preferred, from the viewpoint of sustained carbonation (popping) feeling, a combination of carrageenan and cellulose gum is particularly preferred, from the viewpoint of moist skin feeling, a combination of xanthan gum and hydroxypropyl methylcellulose stearoxy ether, a combination of tamarind gum and cellulose gum, a combination of carrageenan and hydroxypropyl methylcellulose stearoxy ether, a combination of carrageenan and hydroxypropyl methyl cellulose stearoxy ether are particularly preferred, and from the viewpoint of uniformity of foam, a combination of xanthan gum and hydroxyethyl cellulose, a combination of tamarind gum and cellulose gum, a combination of carrageenan and hydroxyethyl cellulose, a combination of carrageenan and hydroxypropyl methylcellulose stearoxy ether are particularly preferred.

[0037] Furthermore, combinations that are not preferred because they do not achieve both an excellent feel when used and an effect of improving skin condition include a combination of sodium alginate with xanthan gum, cellulose gum, hydroxypropyl methylcellulose, carbomer, polyvinyl alcohol, or bentonite; a combination of xanthan gum with cellulose gum, hydroxypropyl methylcellulose, or bentonite; or a combination of cellulose gum with hydroxypropyl methylcellulose or carbomer.

[0038] The content of the thickener in (A), (B), (C), (D), (E), and / or (F) of the present invention is preferably 0.01 to 40 parts by mass, more preferably 0.1 to 30 parts by mass, relative to 100 parts by mass of the total amount of the two agents in the corresponding kit. The amount of thickener in the acid-containing composition and / or base-containing composition referred to here refers to the amount of thickener in either one of them if it contains a thickener, or the total amount if both contain a thickener. The same applies to the amount of thickener in the acid- and base-containing composition and / or water-containing composition.

[0039] The blending ratio of two or more thickeners to be combined is preferably such that the content of any one of the thickeners relative to 100 parts by mass of one of the thickeners is 1 part by mass or more and 10,000 parts by mass or less, more preferably 5 parts by mass or more and 5,000 parts by mass or less, and particularly preferably 10 parts by mass or more and 1,000 parts by mass or less.

[0040] <Water> The water that can be used in the present invention may be water that can be used in cosmetics, external medicines, quasi-drugs, etc., but purified water, distilled water, membrane-filtered water, and ion-exchanged water are preferred.

[0041] The content of water in the kits (1) to (3) of the present invention is preferably 20 parts by mass or more and 95 parts by mass or less, and more preferably 30 parts by mass or more and 90 parts by mass or less, relative to 100 parts by mass of the total amount of the two agents in the corresponding kit.

[0042] <Polyhydric alcohol> In the present invention, it is preferable that the external preparation for skin contains polyhydric alcohol, because it can exert high moisturizing effect and improve the feeling of use.The polyhydric alcohol is not particularly limited as long as it can be used in the external preparation for skin, but for example, can be polyglycerol such as glycerin, diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanediol, 1,2-pentanediol, sorbitol, polyglycerol derivatives, reducing sugar such as glucose, fructose, glyceraldehyde, lactose, arabinose, maltose, sugar alcohol such as erythritol, maltitol, sorbitol, xylitol, and the like, and can be used alone or in combination of two or more of them.

[0043] The content of the polyhydric alcohol in (A), (B), (C), (D), (E), and / or (F) of the present invention is preferably 1 part by mass or more and 80 parts by mass or less, and more preferably 5 parts by mass or more and 70 parts by mass or less, relative to 100 parts by mass of the total amount of the two agents in the corresponding kit. The amount of polyhydric alcohol referred to here refers to the amount of polyhydric alcohol contained in one of the kits when it is present, or the total amount when both kits contain polyhydric alcohol.

[0044] <Other ingredients> The foamable external skin preparation kit of the present invention can contain one or more ingredients typically used in external skin preparations, such as active ingredients, preservatives, pH adjusters, oils and fats, fragrances, colorants, antioxidants, antibacterial and antifungal agents, alcohols, surfactants such as nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants, inorganic salts, lubricants, solvents, etc. In addition, in the kit of the present invention, the added ingredients can be used in either the solid composition or the aqueous composition, or in both.

[0045] When other ingredients (ingredients other than water, acidic substances, carbon dioxide-generating substances, thickeners, and polyhydric alcohols) are blended into the foaming topical skin preparation kit of the present invention, it is preferable that the total content of these ingredients be 30% by mass or less, and particularly 25% by mass or less, from the viewpoint of good foaming and carbon dioxide retention.

[0046] <Kit dosage form and amount of ingredients> The kits (1) to (3) are described in further detail below. In the kits (1) to (3), the dosage form of the solid composition of each kit may be in the form of a tablet, pellet, granule, fine granule, or powder, but from the viewpoint of ease of mixing with other agents and production costs, the granule, fine granule, or powder form is preferred.

[0047] The dosage form of the water-containing composition in each kit may be a gel or liquid, but from the viewpoint of ease of use, a gel form is preferred. The viscosity of the liquid formulation at 25°C is preferably less than 3000 mPa·s, more preferably less than 4000 mPa·s. The viscosity of the gel formulation at 25°C is preferably 5000 Pa·s or more. This viscosity is measured, for example, using a viscometer (Brookfield Model RVT). The amount of thickener in the liquid formulation is preferably less than 0.05% by mass, more preferably less than 0.01% by mass, and particularly preferably less than 0.005% by mass. On the other hand, the amount of thickener in the gel formulation is preferably 0.01% by mass or more, more preferably 0.05% by mass or more.

[0048] <Solid composition of the kits (1) to (3)> The preferred amounts of the acid and carbon dioxide-generating substance in the solid compositions of the kits (1) to (3) are as described above. When the other agent is in a gel form, the amount and content of the thickener in these compositions is preferably 0.01% by mass to 20% by mass, and particularly 0.05% by mass to 15% by mass, in terms of good foaming and carbon dioxide gas retention. When the other agent is in a liquid form, the amount and content of the thickener in these compositions is preferably 0.01% by mass to 30% by mass, and particularly 0.05% by mass to 25% by mass, in terms of ease of mixing with the liquid agent and the exertion of foaming and carbon dioxide gas retention.

[0049] When the solid compositions of the kits (1) to (3) are granulated, the following methods can be used.

[0050] When granules are obtained by granulating a mixture of an acidic substance and / or a carbon dioxide-generating substance with other components, the content of the other components is not particularly limited, but is preferably less than 95% by mass in the granules. If the content of the other components exceeds 95% by mass, the foaming property will be reduced, which is not preferred. The method for producing the powder or granules is not limited to the present embodiment, and they can be produced by conventional methods such as dry crushing granulation, wet crushing granulation, fluidized bed granulation, high speed stirring granulation, and extrusion granulation.

[0051] For example, in the production of granules, a matrix base material having a function of forming granules may be used. When a low-melting point compound is used as the matrix base, the carbon dioxide gas-generating substance is added to the low-melting point compound that has been melted by heating in a container such as a beaker, and the mixture is thoroughly stirred and mixed. If necessary, appropriate additives may be added to this. This mixture is further stirred while gradually cooling to room temperature and left to solidify. Once it has solidified to a certain extent, it may be rapidly cooled in a refrigerator or the like.

[0052] Alternatively, for example, the above materials may be charged into a fluidized bed granulator, mixed with an air current for several minutes, and then granulated by spraying water thereon.

[0053] When a low-melting compound is not used as the matrix base, the granulating agent is dissolved or dispersed in a suitable solvent such as water or ethanol in a container such as a beaker, and the carbon dioxide gas generating substance is dissolved or dispersed in this and mixed thoroughly, and then the mixture is heated in an oven or the like to remove the solvent and dried. Once completely solidified, the mixture is pulverized and sieved to make the particle size uniform, and then granulated.

[0054] <Water-containing composition of the kits (1) to (3)> The preferred amounts of the carbon dioxide gas-generating substance and the acidic substance in the water-containing compositions ((B), (D), and (F)) of the kits (1) to (3) are as described above. The water content in the water-containing compositions of the kits (1) to (3) is preferably 20% by mass or more, and particularly 30% by mass or more, from the viewpoints of mixability with the other components ((A), (C), and (E)) of each kit and foaming properties, and is preferably 95% by mass or less, and particularly 90% by mass or less, from the viewpoints of improving the feel during use and improving skin condition.

[0055] When the aqueous composition of the kits (1) to (3) contains a polyhydric alcohol, the proportion of the polyhydric alcohol in the aqueous composition is preferably 1% by mass or more, particularly 10% by mass or more, and is preferably 80% by mass or less, particularly 70% by mass or less, and especially 60% by mass or less, from the viewpoint of improving the feel when used and improving the skin condition.

[0056] Each of the water-containing compositions (1) to (3) may contain moisturizers other than polyhydric alcohols, surfactants, pH adjusters, volatile alcohols, oils and fats, fragrances, animal and plant extracts, etc. For example, moisturizers other than polyhydric alcohols include polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidone carboxylate, almond, avocado, altea, aloe, mallow, ononis, oat, licorice, quince seed, sophora root, gardenia, grapefruit, watercress, gentian, geranium herb, burdock, wheat, Chinese radish, cactus, soapwort, hawthorn, rehmannia, meadowsweet, and ginger. , mallow, mulberry, thyme, cordyceps, houttuynia cordata, mint, Job's tears, hamamelis, rose, cypress, coltsfoot, grape, prune, loofah, linden, hops, pine, quince, horse chestnut, melissa, cornflower, lily, lime, lavender, apple, rice and rice bran, blackcurrant, Ibuki tora-no-miso, Rosa multiflora, Eleuthero, seaweed, and the like can be used alone or in combination.

[0057] The shape of the acidic substance and / or carbon dioxide gas-generating substance can be, for example, irregular, planar, polyhedral, spherical, teardrop-like, fibrous, cylindrical, or fine powder, without any particular limitation. Furthermore, a wide range of particle sizes can be used without any particular limitation. From the viewpoints of ease of handling and ease of mixing with the viscous composition, a particle size distribution of approximately 1,000 μm or less is particularly preferred. The particle size distribution in the present invention can be determined by a conventional laser diffraction / scattering method.

[0058] In the case of the kit (2), for example, a coating layer may be provided on either or both of the acidic substance and / or carbon dioxide gas-generating substance and the other component, or either or both of the carbon dioxide gas-generating substance and the other component may be encapsulated. Furthermore, the acidic substance and / or carbon dioxide gas-generating substance may be compression-molded with a layer that does not contain the carbon dioxide gas-generating substance, acidic substance, or other component sandwiched between them or between the other component to prevent direct contact between them. Known methods can be used to incorporate the acidic substance and / or carbon dioxide gas-generating substance and the other component into the same formulation.

[0059] The mixing ratio (mass ratio) of the aqueous composition to the solid composition in the kits (1) to (3) is preferably 1:0.01 or more and 30 or less, more preferably 1:0.05 or more and 20 or less.

[0060] The amounts of the acidic substance, carbon dioxide gas-generating substance, thickener, and water used in the composition obtained by the topical skin preparation kit of the present invention are preferably 0.1 to 15% by mass of the acidic substance, 0.1 to 20% by mass of the carbon dioxide gas-generating substance, 0.1 to 20% by mass of the thickener, and 40 to 99.6% by mass of the water, relative to their total weight. Furthermore, when the topical skin preparation contains a polyhydric alcohol, the amounts of the acidic substance, carbon dioxide gas-generating substance, thickener, water, and polyhydric alcohol used in the mixing to obtain the topical skin preparation are preferably 0.1 to 10% by mass of the acidic substance, 0.1 to 10% by mass of the carbon dioxide gas-generating substance, 0.1 to 15% by mass of the thickener, 30 to 97% by mass of water, and 0.05 to 50% by mass of the polyhydric alcohol, relative to their total weight.

[0061] <Usage of the skin topical agent kit> The topical skin preparation of the present invention promotes an increase in skin blood flow due to the action of carbon dioxide gas. The topical skin preparation of the present invention is excellent in improving skin condition by increasing skin moisture content, reducing water evaporation, and improving skin elasticity. Furthermore, the topical skin preparation of the present invention is excellent in terms of feel during use (ease of mixing, smoothness of foam, fineness of foam, uniformity of foam, ease of application, resistance to dripping, foam elasticity, carbonation and its duration, etc.) and in terms of feel after use (skin moisture, elasticity, brightness, redness, smoothness, silky feeling, firmness, etc.). Furthermore, the topical skin preparation of the present invention can be suitably used not only for cosmetics intended to improve skin quality, rejuvenate skin, tighten skin, slim down spots, cleanse skin, condition skin, improve skin texture, keep skin healthy, prevent rough skin, tighten skin, moisturize skin, replenish and maintain skin moisture and oil, maintain skin flexibility, protect skin, prevent skin dryness, soften skin, firm skin, impart luster to skin, smooth skin, and make fine wrinkles caused by dryness less noticeable, but also for pharmaceuticals such as quasi-drugs and drugs intended to prevent rough skin, irritation, heat rash, frostbite, cracks, chapped skin, acne, oily skin, razor burn, and redness after sunburn and snowburn, tighten skin, cleanse skin, condition skin, keep skin healthy, moisturize skin, protect skin, and prevent skin dryness. Furthermore, when used on the scalp and hair, the effect of imparting gloss and smoothness to the hair and elasticity and moisturizing feeling to the scalp is enhanced. Furthermore, the blood flow improving effect is expected to promote proliferation of hair papilla cells and hair growth. The topical skin preparation according to the present invention is preferably used as a cosmetic or quasi-drug, and is preferably used as a cosmetic or medicated cosmetic such as an emulsion, cream, pack, or peeling agent. In particular, use as a pack is preferred because it provides a pleasant feel when used and is likely to achieve a high effect of improving skin condition. [Example]

[0062] The present invention will be described in more detail below with reference to examples, but the scope of the present invention is not limited to these examples. In the following examples and comparative examples, commercially available raw materials were used unless otherwise specified.

[0063] <Production of foaming topical skin preparation> The components listed in Tables 1 to 3 were blended and mixed in the compositions shown in the tables to produce topical skin preparation kits for each Example and Comparative Example. In Tables 1 to 3, acidic substances are also referred to simply as "acids," and carbon dioxide gas-generating substances are also referred to simply as "carbonates."

[0064] [Table 1]

[0065] [Table 2]

[0066] [Table 3]

[0067] The above-mentioned Examples and Comparative Examples were subjected to the following [Evaluation 1]. [Rating 1] Two healthy women in their 20s and 30s were randomly selected as subjects. Each subject washed the inside of their forearm with facial cleanser and rested in the measurement room for 15 minutes. Next, the amount of water evaporation, stratum corneum moisture content, and elasticity were measured using the following method on a 4cm x 4cm measurement area where the foaming topical skin preparation was to be applied. Next, the foaming topical skin preparation was applied to the measurement area and left to stand for 10 minutes. The foaming topical skin preparation was then removed and washed with water. 15 minutes after washing, the same measurements were performed after using the foaming topical skin preparation. The subjects rested in the measurement room during the measurements. The results of measuring the skin condition after use are shown in Figures 1 to 3. The values ​​in Figures 1 to 3 are relative values ​​(rate of change) when the value measured before application of the foaming topical skin preparation is set to 1. For the amount of water evaporation, a smaller value indicates a better result with a well-established barrier function, a larger value indicates a better stratum corneum moisture content, and a larger value indicates a better elasticity.

[0068] The skin conditions before and after application of the foaming topical skin preparation were measured using the following devices, each according to the standard method described in the instruction manual attached to the device. Water evaporation rate: Measured using a Tevameter (registered trademark) TM300 (CK Corporation). Stratum corneum moisture content: Measured using the SKICON-200EX skin surface stratum corneum moisture content measuring device (manufactured by IBS). This skin surface stratum corneum moisture content measuring device evaluates the skin's conductance (electrical conductivity, unit: μS) as the moisture content of the stratum corneum. Elasticity: Measured using a skin viscoelasticity measuring device, Cutometer MPA580 (manufactured by Courage+Khazaka).

[0069] As shown in Figures 1 to 3, the foaming topical skin preparations of each Example, which contained a specific combination of two or more thickeners, showed a greater increase in stratum corneum moisture content and elasticity, and a smaller decrease in water evaporation rate, compared to the foaming topical skin preparations of each Comparative Example, which did not contain these combinations of thickeners. Furthermore, as is clear from Examples 1 to 3, all kits (1) to (3) showed a high skin condition-improving effect. Therefore, it is clear that the foaming topical skin preparations of the present invention, which contain a specific combination of two or more thickeners, have a high skin condition-improving effect.

[0070] The following [Evaluation 2] was carried out for the above Examples and Comparative Examples. [Rating 2] Two healthy women in their 20s and 30s were randomly selected as subjects. Each subject's inner forearm was washed with facial cleanser and allowed to rest for 15 minutes in the measurement room. Next, the above-mentioned foaming topical skin preparation was applied to the measurement site and left to stand for 10 minutes. Next, the foaming topical skin preparation was removed and the subject was washed with water. Evaluation items (16 items) during and after use were evaluated based on a 7-point rating scale. The rating criteria are shown in Table A below, and the results are shown in Tables B to D below. The results below are the average of the evaluation scores of the two subjects.

[0071] [Table A]

[0072] [Table B]

[0073] [Table C]

[0074] [Table D]

[0075] As shown in Tables B to D, the foaming topical skin preparations of each Example, which contained a combination of two or more specific thickeners, were superior in terms of feel during use (ease of mixing, smoothness of foam, fineness of foam, uniformity of foam, ease of application, resistance to dripping, foam elasticity, carbonated feeling and its duration) compared to the foaming topical skin preparations of each Comparative Example, which did not contain these thickeners. They also had superior feel after use (skin moistness, elasticity, brightness, redness, smoothness, silky feeling, firm feeling). Furthermore, as is clear from Examples 1 to 3, the feel of use was excellent for any of the kits (1) to (3).

[0076] Therefore, it is clear that the foamable skin topical preparation of the present invention, which contains a combination of two or more specific thickeners, has both an excellent effect of improving skin conditions and a pleasant feel when used.

Claims

1. A kit for obtaining a foaming skin topical preparation obtained by mixing an acidic substance, a carbon dioxide gas generating substance that generates carbon dioxide gas upon reaction with the acidic substance, two or more thickeners, and water, wherein the thickener is a combination of carrageenan and one or more selected from tamarind gum and hydroxyethyl cellulose, or a combination of hydroxyethyl cellulose and xanthan gum, and further comprising any one of the following components (1) to (3): (1) A solid composition (A) containing an acidic substance and a composition (B) containing water, a thickener, and a carbon dioxide-generating substance. (2) A solid composition (C) containing an acidic substance and a carbon dioxide-generating substance, and a composition (D) containing water and a thickener. (3) A solid composition (E) containing a carbon dioxide-generating substance and a composition (F) containing water, a thickener, and an acidic substance (However, this does not include the following combinations of thickeners (B), (D), and (F): A combination of sodium alginate and xanthan gum, cellulose gum, hydroxypropyl methylcellulose, carbomer, polyvinyl alcohol, or bentonite; a combination of xanthan gum and cellulose gum, hydroxypropyl methylcellulose, or bentonite; or a combination of cellulose gum and hydroxypropyl methylcellulose or carbomer.

2. 2. The kit according to claim 1, wherein one or both of the compositions constituting the kit further contains a polyhydric alcohol.

3. 3. A kit for obtaining the foamable topical skin preparation according to claim 1 or 2, characterized in that the solid compositions ((A), (C), (E)) are in powder form, and the compositions containing water and a thickener ((B), (D), (F)) are in gel form.

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