Anti-aging care composition containing fragrance

Abstract

The present invention relates to the use of diethylamino hydroxybenzoyl hexyl benzoate in anti-aging care compositions comprising at least one fragrance, and to body care compositions comprising diethylamino hydroxybenzoyl hexyl benzoate and at least one fragrance for use in methods for preventing skin reactions.

Description

[Technical Field]

[0001] The present invention relates to the use of diethylamino hydroxybenzoyl hexyl benzoate in anti-aging care compositions containing at least one fragrance. [Background technology]

[0002] Ultraviolet (UV) radiation causes harmful effects on human skin. In addition to the acute effect of sunburn on the skin, UV radiation is also known to increase the risk of skin cancer. Furthermore, prolonged exposure to UV-A and UV-B rays can cause phototoxic and photoallergic reactions on the skin, which may accelerate skin aging. Therefore, UV filters are suitable ingredients for anti-aging care compositions.

[0003] To protect human skin from ultraviolet rays, various sunscreen UV filters (also called UV absorbers) exist, including UV-A filters, UV-B filters, and broadband filters. These filters are added to sunscreens or cosmetic compositions, for example. UV filters are either organic or inorganic, particulate or non-particulate compounds, all of which have high absorption effects within the UV light range. Generally, UV light can be divided into UV-A rays (320-400 nm) and UV-B rays (280-320 nm). Depending on the position of the absorption maximum, UV filters are divided into UV-A filters and UV-B filters. When a UV filter absorbs both UV-A and UV-B rays, it is called a broadband absorber.

[0004] Since 2006, the European Commission has recommended that all sunscreens or cosmetic compositions should have a UV-A protection factor of at least one-third of the labeled sun protection factor (SPF), where the sun protection factor primarily refers to UV-B protection.

[0005] 2-(4'-Diethylamino-2'-hydroxybenzoyl)benzoic acid hexyl ester (also known as diethylaminohydroxybenzoylhexyl benzoate or DHHB) is an effective UV-A filter and is used to protect the skin from ultraviolet rays (e.g., in sunscreens). 2-(4'-Diethylamino-2'-hydroxybenzoyl)benzoic acid hexyl ester is represented below and is also referred to below as the compound of formula (I):

[0006] [ka]

[0007] EP2276452 and EP2276449 relate to cosmetic preparations containing DHHB and at least one fragrance to test for odor stability.

[0008] Anti-aging care compositions often contain additional fragrances that contribute to a pleasant odor. However, fragrances tend to react with free radicals when exposed to UV light. This can cause radical chain reactions that destabilize the formulation itself. Therefore, when considering protection against UV radiation, the effectiveness of UV filters in such unstable formulations is also reduced. Furthermore, the presence of hydroperoxides and other peroxide free radicals is known to induce contact skin diseases and severe allergic reactions (Bjoerkman et al., Contact Dermatitis, 70, 2014, 129-138). [Prior art documents] [Patent documents]

[0009] [Patent Document 1] EP2276452 [Patent Document 2] EP2276449 [Non-patent literature]

[0010] [Non-Patent Document 1] Bjoerkman et al., Contact Dermatitis, 70, 2014, 129-138 Summary of the Invention

[0011] Since anti-aging care compositions are often applied to body parts directly exposed to ultraviolet light, there is a continuing need to provide an anti-aging care composition comprising at least one fragrance that can be safely applied to body parts exposed to ultraviolet light.In this regard, the object of the present invention was to provide an anti-aging care composition comprising at least one fragrance that reduces the formation of free radicals.Furthermore, the object of the present invention was to provide an anti-aging care composition comprising at least one fragrance that reduces lipid peroxidation.Finally, the object of the present invention was to provide a body care composition for use in a method for preventing skin reactions caused by fragrances.

[0012] It has surprisingly been found that at least one of the above objectives can be achieved by the use of diethylaminohydroxybenzoylhexyl benzoate in a body care composition comprising at least one fragrance.

[0013] In particular, the inventors have found that oxidative degradation is reduced when DHHB is used in an anti-aging care composition that includes at least one fragrance.

[0014] The present invention therefore relates in a first aspect to the use of diethylamino hydroxybenzoyl hexyl benzoate in an anti-aging care composition comprising at least one fragrance.

[0015] In the following, preferred embodiments of use are described in further detail, with it being understood that each preferred embodiment is relevant both by itself and in combination with other preferred embodiments.

[0016] In a preferred embodiment A1 of the first aspect, diethylamino hydroxybenzoyl hexyl benzoate in the anti-aging care composition comprising at least one fragrance is used to reduce oxidative degradation.

[0017] In a preferred embodiment A2 of the first aspect, diethylamino hydroxybenzoyl hexyl benzoate in the anti-aging care composition comprising at least one fragrance is used to reduce lipid peroxidation.

[0018] In a preferred embodiment A3 of the first aspect, the anti-aging care composition further comprises butyl methoxydibenzoylmethane.

[0019] In a preferred embodiment A4 of the first aspect, the anti-aging care composition further comprises at least one further UV filter.

[0020] In a preferred embodiment A5 of the first aspect, the at least one fragrance is selected from the group consisting of limonene, citral, linalool, alpha-isomethyl ionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert.-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amyl cinnamaldehyde, alpha-methyl ionone, amyl C butylphenyl methylpropional, cinnamal, amylsa Citric acid, amyl cinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, orange oil, bitter orange oil, butylphenyl methylpropional, cardamom oil, cedrol, cinnamaldehyde, cinnamyl alcohol, citronellyl methyl crotonate, lemon oil, coumarin, diethylsuccinate, ethyl linalool, eugenol, evernia furfurracea extract, evernia prunastri extract, farnesol, guaiac wood oil wood oil), hexyl cinnamal, hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linalyl acetate, mandarin oil, menthyl PCA, methylheptenone, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, vanillin, and mixtures thereof.

[0021] In a preferred embodiment A6 of the first aspect, the at least one fragrance is selected from the group consisting of geraniol, linalool, hydroxycitronellal, alpha-isomethyl ionone, citral, coumarin, limonene, citronellol, benzyl benzoate, benzyl salicylate, hexyl cinnamaldehyde, vanillin, eugenol, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof, in particular the at least one fragrance is selected from the group consisting of geraniol, alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, eugenol, and mixtures thereof.

[0022] In a preferred embodiment A7 of the first aspect, the at least one fragrance is selected from the group consisting of geraniol, linalool, alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof, preferably the at least one fragrance is selected from the group consisting of geraniol, linalool, alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof, Preferably the at least one flavoring agent is selected from the group consisting of aldehydes, vanillin, orange oil, cinnamaldehyde, and mixtures thereof, more preferably the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, vanillin, cinnamaldehyde, bitter orange oil, and mixtures thereof, especially the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, citral, hexyl cinnamaldehyde, and mixtures thereof.

[0023] In a preferred embodiment A8 of the first aspect, the anti-aging care composition comprises hexyl cinnamaldehyde, diethylamino hydroxybenzoyl hexyl benzoate, optionally butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

[0024] In a preferred embodiment A9 of the first aspect, the anti-aging care composition comprises at least one fragrance, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

[0025] In a preferred embodiment A10 of the first aspect, the anti-aging care composition comprises: at least one fragrance in an amount of 0.00001 to 1% by weight, preferably 0.001 to 0.5% by weight, relative to the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 10% by weight, preferably 0.1 to 8% by weight, relative to the total weight of the anti-aging care composition; Optionally, butyl methoxydibenzoylmethane in an amount of 0.1 to 5% by weight, preferably 0.1 to 4% by weight, relative to the total weight of the anti-aging care composition; and Optionally, at least one further UV filter in an amount of from 0.1 to 10% by weight, preferably from 0.1 to 8% by weight, relative to the total weight of the anti-aging care composition. Includes:

[0026] In a preferred embodiment A11 of the first aspect, the anti-aging care composition comprises at least one fragrance in an amount of 0.001 to 0.5% by weight, based on the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition; butyl methoxydibenzoylmethane in an amount of 0.1 to 4% by weight relative to the total weight of the anti-aging care composition; Optionally, at least one further UV filter in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition. Includes:

[0027] In a preferred embodiment A12 of the first aspect, the anti-aging care composition further comprises a dermatologically acceptable emulsifier, thickener, and / or emollient.

[0028] In a preferred embodiment A13 of the first aspect, the anti-aging care composition is free of polyethylene glycol and polypropylene glycol.

[0029] In a preferred embodiment A14 of the first aspect, the anti-aging care composition does not comprise ethylhexyl methoxycinnamate and octocrylene.

[0030] In a preferred embodiment A15 of the first aspect, diethylamino hydroxybenzoyl hexyl benzoate in the anti-aging care composition comprising at least one fragrance is used to reduce lipid peroxidation caused by ultraviolet light.

[0031] In a preferred embodiment A16 of the first aspect, diethylamino hydroxybenzoyl hexyl benzoate in the anti-aging care composition comprising at least one fragrance is used to reduce aldehyde formation caused by ultraviolet light, in particular to reduce the formation of malondialdehyde.

[0032] In a second aspect, the present invention relates to a body care composition comprising diethylaminohydroxybenzoylhexyl benzoate and at least one fragrance for use in a method for preventing skin conditions and / or allergic reactions caused by fragrances. DETAILED DESCRIPTION OF THE INVENTION

[0033] Before describing exemplary embodiments of the present invention in detail, definitions important for understanding the present invention are provided.

[0034] As used in this specification and the appended claims, the singular forms "a" and "an" include the respective plural forms as well, unless the context clearly dictates otherwise. In the context of the present invention, the terms "about" and "approximately" indicate an accuracy interval that a person skilled in the art would understand to still ensure the technical effect of the feature in question. This term typically indicates a deviation from the indicated numerical value of ±20%, preferably ±15%, more preferably ±10%, and even more preferably ±5%. It should be understood that the term "comprising" is not limiting. For the purposes of the present invention, the term "consisting of" is considered to be a preferred embodiment of the term "comprising of". Hereinafter, when a group is defined as comprising at least a certain number of embodiments, this also preferably encompasses groups consisting only of these embodiments. Furthermore, in the present specification and claims, the terms "first," "second," "third," or "(a)," "(b)," "(c)," "(d)," etc. are used to distinguish between similar elements in the description and claims and do not necessarily describe a sequential or chronological order. It is to be understood that terms so used are interchangeable under appropriate circumstances, and that embodiments of the invention described herein are capable of operation in sequences other than those described or exemplified herein. When terms such as "first," "second," "third," or "(a)," "(b)," "(c)," "(d)," "i," "ii," etc. refer to steps in a method, use, or assay, in this application, unless otherwise indicated herein above or below, there is no time coherence or time interval coherence between the steps, i.e., steps may be performed simultaneously, or there may be time intervals of seconds, minutes, hours, days, weeks, months, or even years between such steps. It is to be understood, however, that the invention is not limited to the particular methodology, protocols, reagents, etc. described herein, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the invention, which is limited only by the appended claims. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0035] The term "compound of formula (I)" refers to 2-(4'-diethylamino-2'-hydroxybenzoyl)benzoic acid hexyl ester (also known as diethylaminohydroxybenzoylhexyl benzoate or DHHB).

[0036] The term "body care composition" refers to any product suitable for application to the human body, such as anti-aging care compositions, sunscreen compositions, bath and shower products, preparations containing fragrances and odoriferous substances, hair care products, dentifrices, decorative preparations, and cosmetic formulations containing active ingredients. Sunscreen compositions are preferred.

[0037] The term "sunscreen composition" or "sunscreen agent" refers to any topical product that reflects and / or absorbs a specific portion of ultraviolet radiation. Therefore, the term "sunscreen composition" should be understood to include not only sunscreen compositions but also any cosmetic composition that provides UV protection. The term "topical product" refers to a product that is applied to the skin and may be, for example, a spray, lotion, cream, oil, foam, powder, or gel. According to the present invention, the sunscreen composition may contain one or more active agents, such as organic UV filters, as well as other ingredients or additives, such as emulsifiers, emollients, viscosity modifiers, stabilizers, preservatives, or fragrances.

[0038] The term "anti-aging care composition" refers to any topical product that can absorb, and further reflect and scatter a certain portion of ultraviolet radiation, and is used as a daily care product for the human body, for example, face, body, or hair.Anti-aging care compositions can contain one or more active agents, such as organic or inorganic UV filters, and other ingredients or additives, such as emulsifiers, emollients, viscosity adjusters, stabilizers, preservatives, or fragrances.It should be understood that the anti-aging care composition according to the present invention provides a reduction in oxidative degeneration and limits the skin aging process induced by free radicals.

[0039] Suitable bath and shower additives are, for example, shower gels, bath salts, bubble baths and soaps.

[0040] Suitable preparations containing fragrances and odoriferous substances are, in particular, scents, perfumes, toilet waters and shaving lotions (aftershave preparations).

[0041] Suitable hair care products are, for example, shampoos for humans and animals (especially dogs), hair conditioners, products for styling and treating hair, perms, hair sprays and hair lacquers, hair gels, hair fixatives, and hair dyes or hair bleaches.

[0042] Suitable dentifrices are, for example, tooth creams, tooth powders, mouthwashes, mouth rinses, anti-plaque preparations and denture cleaners.

[0043] Suitable decorative preparations are, for example, lipsticks, nail varnishes, eye shadows, mascaras, dry and moist make-up, rouge, powders, depilatories and suntan lotions.

[0044] Suitable cosmetic preparations containing active ingredients are, for example, hormone preparations, vitamin preparations, plant extract preparations and antibacterial preparations.

[0045] The body care compositions cited may be in the form of creams, ointments, pastes, foams, gels, lotions, powders, make-ups, sprays, sticks or aerosols, and they preferably contain a compound of formula (I) in a lipophilic phase.

[0046] The term "emollient" relates to cosmetic preparations used to protect, moisturize and lubricate the skin. The word emollient comes from the Latin "mollire" (to soften). Generally, emollients prevent the evaporation of water from the skin by forming an occlusive coating. They can be divided into different groups according to their polarity index.

[0047] The term "photostability" refers to the ability of a UV filter or any other molecule exposed to sunlight to remain stable upon irradiation. In particular, this means that the compound does not undergo decomposition processes upon UV irradiation.

[0048] The term "critical wavelength" is defined as the wavelength at which the area under the UV protection curve (% protection vs. wavelength) is 90% of the total area under the curve in the UV region (280-400 nm). For example, a critical wavelength of 370 nm indicates that the protection of a sunscreen composition is not limited to UV-B wavelengths, i.e., wavelengths between 280 and 320 nm, but extends up to 370 nm, such that 90% of the total area under the protection curve in the UV region reaches 370 nm.

[0049] The term "ultraviolet filter" or "UV filter" as used herein refers to an organic or inorganic compound that can absorb and / or reflect ultraviolet radiation generated by sunlight. UV filters can be classified as UV-A filters, UV-B filters, or broadband filters based on their UV protection curves. In the context of this application, broadband filters can also be referred to as UV-A filters, since they also provide UV-A protection. In other words, preferred UV-A filters also include broadband filters.

[0050] The definition of "broadband" protection (also called broad spectrum or broad-spectrum protection) is based on "critical wavelengths." Broad-spectrum coverage must provide UV-B and UV-A protection. According to U.S. requirements, a critical wavelength of at least 370 nm is required to achieve broad-spectrum protection. Furthermore, the European Commission recommends that all sunscreens or cosmetic compositions should have a UVA protection factor of at least one-third of the labeled sun protection factor (SPF); for example, if a sunscreen composition has an SPF of 30, the UVA protection factor must be at least 10.

[0051] Preferred embodiments for use according to the invention are described hereinafter, it being understood that the preferred embodiments of the invention are preferred either alone or in combination with each other.

[0052] As indicated above, the present invention relates in one embodiment to the use of diethylamino hydroxybenzoyl hexyl benzoate in an anti-aging care composition comprising at least one fragrance.

[0053] Preferred embodiments for use are defined hereinafter.

[0054] The diethylaminohydroxybenzoylhexyl benzoate used in the anti-aging care composition comprising at least one fragrance according to the invention may be contained in the anti-aging care composition in an amount of 0.1 to 10% by weight, preferably 0.1 to 9% by weight, more preferably 0.1 to 8% by weight, even more preferably 0.1 to 7% by weight, or 0.1 to 6% by weight or 0.1 to 5% by weight, in particular 0.1 to 4% by weight, relative to the total weight of the anti-aging care composition.

[0055] In one embodiment of the present invention, diethylaminohydroxybenzoylhexylbenzoate is used in the anti-aging care composition containing at least one fragrance to reduce oxidative degradation.Oxidation (i.e., oxidative degradation) of sensitive ingredients after UV irradiation can occur in the anti-aging care composition containing at least one fragrance or in the applied film.In this regard, it should be understood that the generated free radicals can further react with compounds present on the skin, such as compounds present in the formulation or components derived from sebum, or with sensitive skin molecules, resulting in undesirable skin reactions caused by the fragrance.

[0056] In one embodiment of the invention, diethylamino hydroxybenzoyl hexyl benzoate in the anti-aging care composition comprising at least one fragrance is used to reduce oxidative degradation in the formulation or on the skin.

[0057] In one embodiment of the present invention, diethylaminohydroxybenzoylhexylbenzoate in the anti-aging care composition comprising at least one fragrance is used to reduce lipid peroxidation. In this context, it is to be understood that the formation of lipid peroxides or lipid oxidation products (LOP) is reduced. Furthermore, according to one embodiment of the present invention, diethylaminohydroxybenzoylhexylbenzoate in the anti-aging care composition comprising at least one fragrance is used to reduce damage to cell membranes.

[0058] In one embodiment of the present invention, the anti-aging care composition further comprises butyl methoxydibenzoylmethane (also known as 4-(tert.-butyl)-4'-methoxydibenzoylmethane or BMDBM), which may be present in the anti-aging care composition in an amount of 0.1 to 5 wt. %, preferably 0.2 to 4.5 wt. %, more preferably 0.3 to 3 wt. %, and in particular 0.5 to 2 wt. %, relative to the total weight of the anti-aging care composition.

[0059] In one embodiment of the invention, the anti-aging care composition further comprises at least one further UV filter, which may be contained in the anti-aging care composition in an amount of 0.1 to 10% by weight, preferably 0.2 to 9% by weight, more preferably 0.3 to 8% by weight, even more preferably 0.4 to 7% by weight, or 0.4 to 6% by weight, in particular 0.5 to 5% by weight, relative to the total weight of the anti-aging care composition.

[0060] The at least one additional UV filter may be selected from the group consisting of UV-A filters, UV-B filters, broadband filters, and mixtures thereof. Suitable UV filters may be organic or inorganic compounds, and may be particulate or non-particulate compounds.

[0061] In one embodiment of the present invention, the at least one further UV filter is an organic UV filter.

[0062] In another embodiment of the present invention, the at least one further UV filter is an inorganic UV filter. Suitable inorganic UV filters can be, by way of example, zinc oxide and titanium dioxide.

[0063] In another embodiment of the invention, the anti-aging care composition comprises at least one organic UV filter and at least one inorganic UV filter.

[0064] In one embodiment of the present invention, the at least one further UV filter is selected from the group consisting of triazine derivatives, dibenzoylmethane derivatives, benzotriazole derivatives, benzimidazole derivatives and combinations thereof.

[0065] In a preferred embodiment, the at least one further UV filter is preferably a UV-A filter selected from the group consisting of 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5 triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine), 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol (INCI drometrizole trisiloxane), 2-(2H-benzotriazol-2-yl)-6-(2-ethylhexyloxymethyl)-4-methyl-phenol, methylenebis-benzotriazolyltetramethylbutylphenol, terephthalylidene dicamphorsulfonic acid, and combinations thereof.

[0066] In another preferred embodiment, the at least one further UV filter is a UV-B filter, preferably selected from the group consisting of 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tris-benzoic acid-tris(2-ethylhexyl)ester (INCI Ethylhexyl Triazone), malonate derivatives such as dimethicone diethylbenzalmalonate, diethylhexylbutamidotriazone, phenylbenzimidazole sulfonic acid, and combinations thereof.

[0067] In one embodiment of the present invention, the at least one further UV filter is selected from the group consisting of 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI Bis-ethylhexyloxyphenol methoxyphenyl triazine), 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol (INCI Drometrizole Trisiloxane), 2-(2H-benzotriazol-2-yl)-6-(2-ethylhexyloxymethyl)-4-methyl-phenol, 4,4′,4″-(1,3,5-triazine-2,4,6-triyltriimino)tris-benzoic acid-tris(2-ethylhexyl)ester (INCI ethylhexyltriazone), malonate derivatives such as dimethicone diethyl benzalmalonate, diethylhexylbutamidotriazone, 4,4'-[[6-[[4-[[(1,1-dimethylethyl)amino]carbonyl]phenyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-benzoic acid-bis(2-ethylhexyl) ester, [(3Z)-3-[[4-[(Z)-[7,7-dimethyl-2-oxo-1-(sulfomethyl)-3-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid (INCI terephthalylidene dicamphorsulfonic acid), disodium phenyl dibenzimidazole tetrasulfonate, phenylbenzimidazole sulfonic acid, and combinations thereof.

[0068] In one embodiment of the present invention, the at least one further UV filter is selected from the group consisting of 2,4-bis-{[4-(2-ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5 triazine (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine), 4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)tris-benzoic acid-tris(2-ethylhexyl) ester (INCI ethylhexyltriazone), 4,4'-[[6-[[4-[[(1,1-dimethylethyl)amino]carbonyl]phenyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-benzoic acid-bis(2-ethylhexyl) ester (INCI diethylhexyl-butamidotriazone), and mixtures thereof.

[0069] In one embodiment of the present invention, the at least one additional UV filter is selected from the group consisting of [(3Z)-3-[[4-[(Z)-[7,7-dimethyl-2-oxo-1-(sulfomethyl)-3-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid (INCI terephthalylidene dicamphorsulfonic acid), disodium phenyl dibenzimidazole tetrasulfonate, phenylbenzimidazole sulfonic acid, and combinations thereof.

[0070] Any suitable fragrance can be used as the at least one fragrance according to the present invention. The at least one fragrance can be contained in the anti-aging care composition in an amount of 0.00001 to 1% by weight, preferably 0.0001 to 0.9% by weight, more preferably 0.001 to 0.8% by weight, or 0.001 to 0.7% by weight, in particular 0.01 to 0.6% by weight, relative to the total weight of the anti-aging care composition.

[0071] In one embodiment of the present invention, the at least one fragrance is selected from the group consisting of limonene (also known as 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene), citral (also known as 3,7-dimethylocta-2,6-dienal), linalool (also known as 3,7-dimethyl-1,6-octadien-3-ol), alpha-isomethylionone (also known as alpha-cetone), geraniol (also known as (2E)-3,7-dimethyl-2,6-octadien-1-ol), citronellol (also known as 3,7-dimethyloct-6-en-1-ol), 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert.-Pentyl cyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amyl cinnamaldehyde, alpha-methyl ionone, amyl C butylphenyl methylpropional cinnamal, amyl salicylate, amyl cinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate (also known as benzyl 2-hydroxybenzoate), bergamot oil, orange oil, bitter orange oil, butylphenyl methylpropional, cardamom oil, cedrol, cinnamaldehyde (also known as (2E)-3-phenylprop-2-enal), cinnamyl alcohol, citronellyl methyl crotonate, lemon Oil, coumarin (also known as 2H-chromen-2-one), diethylsuccinate, ethyl linalool, eugenol (also known as 2-methoxy-4-(prop-2-en-1-yl)phenol), evernia furfurracea extract, evernia prunastri extract, farnesol, guaiac wood oil, hexyl cinnamal (also known as hexyl cinnamaldehyde or 2-benzylidene octanal), hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linalyl acetate, mandarin oil, menthyl PCA, methylheptenone, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, vanillin (also known as 4-hydroxy-3-methoxybenzaldehyde), and mixtures thereof.

[0072] In one embodiment of the present invention, at least one perfume is a sensitive perfume.In this context, the term "sensitive perfume" is understood to refer to a perfume that is sensitive to oxidative degradation, in particular to oxidative degradation caused by ultraviolet light.This sensitivity can be determined using the following test:

[0073] To measure free radical generation in the formulation after UV irradiation, the concentration of photostable spin markers added to the test samples was followed by electron spin resonance (ESR) spectroscopy before and after UV irradiation of the test samples. The photostable spin markers react readily with free radicals generated in the formulation after UV irradiation.

[0074] The test fragrance is incorporated into a formulation at 0.1% (w / w). The formulation is then diluted with distilled water (1:10 dilution ratio) and an aqueous solution of the spin marker PCA (2,2,5,5-tetramethylpyrrolidine N-oxyl) is added to obtain a spin marker concentration of 0.01 mM. Knowing the concentration of the spin trap PCA in the formulation, the amount of PCA lost can be calculated (Herrling et al., SOFW-Journal, 5-2014, 140, 10-16). The sample is inserted into a capillary quartz tube and ESR measurements are performed 20 minutes before and after UV irradiation. The irradiance as an integral over the spectral range of the solar simulator is, for example, E = 23.5 W / m for UVB. 2 , 180W / m for UVA 2 It could be.

[0075] The percentage of UV-induced free radicals in the formulation containing the tested fragrance serves as an indicator of the sensitivity of said fragrance.According to the above test, the formulation containing the sensitive fragrance contains at least 1%, preferably at least 2%, more preferably at least 3%, even more preferably at least 4%, even more preferably at least 5%, even more preferably at least 10%, even more preferably at least 15%, even more preferably at least 20%, particularly at least 50% of UV-induced free radicals after 20 minutes of UV irradiation.

[0076] In one embodiment of the present invention, the at least one fragrance is selected from the group consisting of geraniol, linalool, hydroxycitronellal, alpha-isomethyl ionone, citral, coumarin, limonene, citronellol, benzyl benzoate, benzyl salicylate, hexyl cinnamaldehyde, vanillin, eugenol, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof.

[0077] In one embodiment of the invention, the at least one fragrance is selected from the group consisting of geraniol, linalool, alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof. In one embodiment of the invention, the at least one fragrance is selected from the group consisting of alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, orange oil, cinnamaldehyde, and mixtures thereof.

[0078] In a preferred embodiment of the present invention, the at least one fragrance is selected from the group consisting of alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, vanillin, cinnamaldehyde, bitter orange oil, and mixtures thereof.

[0079] In one embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, vanillin, cinnamaldehyde, and mixtures thereof. In one embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, citral, benzyl salicylate, hexyl cinnamaldehyde, vanillin, and mixtures thereof. In one embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, hexyl cinnamaldehyde, vanillin, and mixtures thereof. In one embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of hexyl cinnamaldehyde, vanillin, and mixtures thereof.

[0080] In a preferred embodiment of the present invention, the at least one fragrance is selected from the group consisting of geraniol, alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, eugenol, and mixtures thereof.

[0081] In one embodiment of the present invention, the at least one fragrance is selected from the group consisting of alpha-isomethyl ionone, citral, hexyl cinnamaldehyde, and mixtures thereof. In one embodiment of the present invention, the at least one fragrance is hexyl cinnamaldehyde. In another embodiment of the present invention, the at least one fragrance is alpha-isomethyl ionone. In another embodiment of the present invention, the at least one fragrance is citral. In another preferred embodiment of the present invention, the at least one fragrance is geraniol. In another preferred embodiment of the present invention, the at least one fragrance is coumarin. In another preferred embodiment of the present invention, the at least one fragrance is benzyl salicylate. In another preferred embodiment of the present invention, the at least one fragrance is eugenol.

[0082] In one embodiment of the present invention, the at least one flavoring is not selected from the group consisting of linalool, hexyl cinnamal, benzyl salicylate, and citronellol.

[0083] In one embodiment of the invention, the anti-aging care composition comprises hexyl cinnamaldehyde, diethylamino hydroxybenzoyl hexyl benzoate, optionally butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

[0084] In another embodiment of the invention, the anti-aging care composition comprises alpha-isomethyl ionone, diethylamino hydroxybenzoyl hexyl benzoate, optionally butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

[0085] In another embodiment of the invention, the anti-aging care composition comprises citral, diethylaminohydroxybenzoylhexylbenzoate, optionally butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

[0086] In one embodiment of the invention, the anti-aging care composition comprises hexyl cinnamaldehyde, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

[0087] In one embodiment of the present invention, the anti-aging care composition comprises at least one fragrance, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

[0088] In one embodiment of the present invention, the anti-aging care composition comprises: at least one fragrance in an amount of 0.00001 to 1% by weight, preferably 0.001 to 0.5% by weight, relative to the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 10% by weight, preferably 0.1 to 8% by weight, relative to the total weight of the anti-aging care composition; Optionally, butyl methoxydibenzoylmethane in an amount of 0.1 to 5% by weight, preferably 0.1 to 4% by weight, relative to the total weight of the anti-aging care composition; and Optionally, at least one further UV filter in an amount of from 0.1 to 10% by weight, preferably from 0.1 to 8% by weight, relative to the total weight of the anti-aging care composition. Includes:

[0089] In one embodiment of the present invention, the anti-aging care composition comprises: at least one fragrance in an amount of 0.0001 to 1% by weight, preferably 0.001 to 0.5% by weight, relative to the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 8% by weight, preferably 0.1 to 7% by weight, relative to the total weight of the anti-aging care composition; Optionally, butyl methoxydibenzoylmethane in an amount of 0.1 to 4% by weight, preferably 0.1 to 3% by weight, relative to the total weight of the anti-aging care composition; and Optionally, at least one further UV filter in an amount of from 0.1 to 8% by weight, preferably from 0.1 to 6% by weight, relative to the total weight of the anti-aging care composition. Includes:

[0090] In one embodiment of the present invention, the anti-aging care composition comprises: at least one fragrance in an amount of 0.001 to 0.5% by weight, based on the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition; butyl methoxydibenzoylmethane in an amount of 0.1 to 4% by weight relative to the total weight of the anti-aging care composition; Optionally, at least one further UV filter in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition. Includes:

[0091] In one embodiment of the present invention, the anti-aging care composition comprises: at least one fragrance in an amount of 0.01 to 0.4% by weight, based on the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 5% by weight relative to the total weight of the anti-aging care composition; butyl methoxydibenzoylmethane in an amount of 0.1 to 3% by weight relative to the total weight of the anti-aging care composition; Optionally, at least one further UV filter in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition. Includes:

[0092] In one embodiment of the present invention, the anti-aging care composition further comprises at least one further anti-aging ingredient, such as alpha-lipoic acid, ceramide, collagen, coenzyme Q10, disodium uridine phosphate, ethyl ferulate, folic acid, glycolic acid, Helianthus annuus seed oil, hyaluronic acid, jojoba oil, lactic acid, niacinamide, polyglyceryl-5 trioleate, retinol, rosmarinus officinalis, rosmarinus officinalis extract, and vitamin C.

[0093] In one embodiment of the present invention, the anti-aging care composition further comprises a dermatologically acceptable emulsifier, thickener, and / or emollient.

[0094] Preferred emulsifiers include: - glucose derivatives, such as cetearyl glucoside, arachidyl glucoside, lauryl glucoside, polyglyceryl-3 methylglucose distearate, methylglucose sesquistearate; - sucrose derivatives, such as sucrose polystearate, sucrose palmitate; - sorbitol derivatives; - glycerides of fatty acids, such as glyceryl stearate, glyceryl oleate; - glutamic acid derivatives, such as sodium stearoyl glutamate - sulfosuccinic acid derivatives, such as Cetearyl Sulfosuccinate Disodium; - phosphoric acid derivatives, such as potassium cetyl phosphate; - fatty acid esters of polyglyceryl, such as polyglyceryl-3-diisostearate, polyglyceryl-2-dipolyhydroxystearate; - Oxyalkenylated organically modified silicone / polysiloxane / polyalkyl / polyether copolymers and derivatives Examples include:

[0095] Preferred emollients include: - esters of linear or branched fatty acids with linear or branched fatty alcohols, such as, for example, propylheptyl caprylate, cococaprylate, isopropyl myristate, ethylhexyl palmitate; Esters of aromatic carboxylic acids with linear or branched fatty alcohols, for example C 12 -C 15 -Alkyl benzoates, ethylhexyl benzoate, phenethyl benzoate; dicarboxylic acid esters with linear or branched alcohols, such as dibutyl adipate, dicaprylyl carbonate, diisopropyl sebacate; - esters of hydroxycarboxylic acids with linear or branched fatty alcohols; - esters of linear or branched fatty acids with polyhydric alcohols, such as butylene glycol dicaprylate / dicaprate; - C6-C 18 Mono-, di-, tri-glycerides based on fatty acids, such as caprylic / capric triglyceride, cocoglycerides; Guerbet alcohols, such as octyldodecinol; - hydrocarbons, such as hydrogenated polyisobutene, mineral oil, squalene, isohexadecane; - ethers, such as dicaprylyl ether: - Silicone derivatives (organically modified polysiloxanes), such as dimethylpolysiloxane, cyclic silicones Examples include:

[0096] Preferred thickeners (also called viscosity modifiers) include: - fatty alcohols, such as cetyl alcohol, cetearyl alcohol, stearyl alcohol; - fatty acids, such as stearic acid; - fatty acid esters, such as myristyl stearate; - Waxes, such as beeswax, carnauba wax, microcrystalline wax, ceresin, ozokerite; - polysaccharides or derivatives, such as xanthan gum, guar gum, agar gum, alginates, gellan gum, carrageenan; - polyacrylates or reticulated homopolymers of acrylic acid or polyacrylamides, such as carbomers, acrylate copolymers, acrylate / C 10 -C 30 -Alkyl acrylate crosspolymer, acrylates / beheneth-25 methacrylate copolymer; - silicate derivatives, for example magnesium silicate; cellulose derivatives, such as hydroxypropyl cellulose Examples include:

[0097] In one embodiment of the present invention, the anti-aging care composition further comprises an additive selected from the group consisting of sensory enhancers, adjuvants, preservatives, and combinations thereof.

[0098] Preferred feel enhancers include: - polyamide derivatives, for example nylon-12; - Polymethyl methacrylate; - Silica; - mica; - polymethylsilsesquioxane; - polyethylene; - starch derivatives, such as aluminum starch octenylsuccinate; - Dimethicone derivatives; - boron nitride; - HDI / Trimethylolhexyllactone Crosspolymer Examples include:

[0099] Preferred adjuvants include: - tocopherol derivatives; - Retinol derivatives; - ascorbic acid derivatives; - Bisabolol; - Allantoin; - Panthenol; - Chelating agents (EDTA, EDDS, EGTA, phytic acid, piroctone olamine); - Ethylhexylglycerin; - Caprylyl glycol; - Hydroxyacetophenone; - Caprylhydroxamic acid; - Propellants such as propane, butane, isobutene, dimethyl ether; - styrene / PVP or styrene acrylamide copolymer; - Insect repellents such as butyl acetylaminopropionate Examples include:

[0100] Preferred preservatives include: - benzyl alcohol; - Zingerone Examples include:

[0101] In relation to the above embodiments, it should be understood that if the body care composition (e.g. anti-aging care composition) comprises two or more additives, combinations of the additives defined above are also part of the present invention.

[0102] In relation to the above embodiment, the body care composition (e.g. anti-aging care composition) may, in its final formulation, comprise, for example: - liquid formulations as W / O, O / W, O / W / O, W / O / W or PIT emulsions and microemulsions of any kind; - gel; - oils, creams, milks or lotions; - Powders, lacquers, tablets or make-up; - stick; - sprays (sprays with propellant gas or pump-action sprays) or aerosols; - Form; - Paste It should be understood that the present invention may be presented in a variety of different formats, such as:

[0103] In one embodiment of the present invention, the anti-aging care composition is free of polyethylene glycol and polypropylene glycol.

[0104] With regard to the above-described preferred embodiment of the anti-aging care composition, particularly with regard to the UV filters DHHB and BMDBM, the present inventors surprisingly discovered that BMDBM remains stable in the composition. Those skilled in the art understand that BMDBM is a frequently used UV absorber that tends to isomerize upon exposure to UV light to form a triplet diketone. This diketone is highly susceptible to photodecomposition, which leads to the decomposition of BMDBM. Therefore, compositions containing BMDBM require the addition of a stabilizer, and photostable UV absorbers such as ethylhexyl-2-cyano-3,3-diphenylacrylate (INCI octocrylene) are commonly used. Therefore, the present inventors surprisingly discovered that BMDBM can be stabilized in octocrylene-free sunscreen compositions by using the UV filter DHHB, even in the presence of at least one fragrance.

[0105] In one embodiment of the present invention, the anti-aging care composition is free of ethylhexyl methoxycinnamate and octocrylene.

[0106] In one embodiment of the present invention, diethylamino hydroxybenzoyl hexyl benzoate in the anti-aging care composition comprising at least one fragrance is used to reduce lipid peroxidation caused by ultraviolet light.

[0107] In one embodiment of the invention, diethylamino hydroxybenzoyl hexyl benzoate in the anti-aging care composition comprising at least one fragrance is used to reduce aldehyde formation caused by UV rays, preferably to reduce the formation of malondialdehyde.

[0108] In another embodiment, the present invention relates to a body care composition comprising diethylamino hydroxybenzoyl hexyl benzoate and at least one fragrance for use in a method for preventing a skin reaction, preferably a skin disease and / or an allergic reaction. Preferably, the body care composition comprising diethylamino hydroxybenzoyl hexyl benzoate and at least one fragrance is for use in a method for preventing a skin disease and / or an allergic reaction caused by a fragrance.

[0109] In one embodiment of the present invention, the body care composition is a sunscreen.

[0110] In another embodiment of the present invention, the body care composition is an anti-aging care composition.

[0111] In one embodiment of the present invention, the body care composition further comprises butyl methoxydibenzoylmethane.

[0112] In one embodiment of the invention, the body care composition further comprises at least one further UV filter. In this context, suitable further UV filters are mentioned above.

[0113] In one embodiment of the present invention, the at least one fragrance is selected from the group consisting of limonene, citral, linalool, alpha-isomethyl ionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert.-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amyl cinnamaldehyde, alpha-methyl ionone, amyl C butylphenyl methylpropional cinnamal, amyl salicylate, amyl cinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, oleic acid ... The extract is selected from the group consisting of range oil, bitter orange oil, butylphenyl methylpropional, cardamom oil, cedrol, cinnamaldehyde, cinnamyl alcohol, citronellyl methyl crotonate, lemon oil, coumarin, diethylsuccinate, ethyl linalool, eugenol, evernia furfurracea extract, evernia prunastri extract, farnesol, guaiac wood oil, hexyl cinnamal, hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linalyl acetate, mandarin oil, menthyl PCA, methylheptenone, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, vanillin, and mixtures thereof.

[0114] In one embodiment of the present invention, the at least one fragrance is selected from the group consisting of geraniol, linalool, hydroxycitronellal, alpha-isomethyl ionone, citral, coumarin, limonene, citronellol, benzyl benzoate, benzyl salicylate, hexyl cinnamaldehyde, vanillin, eugenol, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof, preferably geraniol, linalool, alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, eugenol, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof. The preferred cinnamaldehyde is selected from the group consisting of alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, orange oil, cinnamaldehyde, and mixtures thereof, more preferably from the group consisting of alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, orange oil, cinnamaldehyde, and mixtures thereof, even more preferably from the group consisting of alpha-isomethyl ionone, citral, hexyl cinnamaldehyde, and mixtures thereof, in particular hexyl cinnamaldehyde.

[0115] In a preferred embodiment of the present invention, the at least one fragrance is selected from the group consisting of alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, vanillin, cinnamaldehyde, bitter orange oil, and mixtures thereof.

[0116] In a preferred embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, vanillin, cinnamaldehyde, and mixtures thereof. In a preferred embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, citral, benzyl salicylate, hexyl cinnamaldehyde, vanillin, and mixtures thereof. In a preferred embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of alpha-isomethyl ionone, hexyl cinnamaldehyde, vanillin, and mixtures thereof. In a preferred embodiment of the present invention, the at least one flavoring agent is selected from the group consisting of hexyl cinnamaldehyde, vanillin, and mixtures thereof.

[0117] In a preferred embodiment of the present invention, the at least one fragrance is selected from the group consisting of geraniol, alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, eugenol, and mixtures thereof.

[0118] In a preferred embodiment of the present invention, the at least one fragrance is selected from the group consisting of geraniol, alpha-isomethyl ionone, citral, coumarin, benzyl salicylate, hexyl cinnamaldehyde, eugenol, and mixtures thereof.

[0119] In a preferred embodiment of the present invention, the fragrance is alpha-isomethylionone. In another preferred embodiment of the present invention, the at least one fragrance is citral. In another preferred embodiment of the present invention, the at least one fragrance is hexyl cinnamaldehyde. In another preferred embodiment of the present invention, the at least one fragrance is geraniol. In another preferred embodiment of the present invention, the at least one fragrance is coumarin. In another preferred embodiment of the present invention, the at least one fragrance is benzyl salicylate. In another preferred embodiment of the present invention, the at least one fragrance is eugenol.

[0120] In one embodiment of the present invention, the body care composition comprises: at least one fragrance in an amount of 0.00001 to 1% by weight, preferably 0.001 to 0.5% by weight, relative to the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 10% by weight, preferably 0.1 to 8% by weight, relative to the total weight of the anti-aging care composition; Optionally, butyl methoxydibenzoylmethane in an amount of 0.1 to 5% by weight, preferably 0.1 to 4% by weight, relative to the total weight of the anti-aging care composition; and Optionally, at least one further UV filter in an amount of from 0.1 to 10% by weight, preferably from 0.1 to 8% by weight, relative to the total weight of the anti-aging care composition. Includes:

[0121] In one embodiment of the present invention, the body care composition comprises: at least one fragrance in an amount of 0.001 to 0.5% by weight, based on the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition; butyl methoxydibenzoylmethane in an amount of 0.1 to 4% by weight relative to the total weight of the anti-aging care composition; Optionally, at least one further UV filter in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition. Includes:

[0122] In one embodiment of the present invention, the body care composition further comprises a dermatologically acceptable emulsifier, thickener, and / or emollient.

[0123] In one embodiment of the present invention, the body care composition is free of polyethylene glycol and polypropylene glycol.

[0124] In one embodiment of the present invention, the body care composition is free of ethylhexyl methoxycinnamate and octocrylene.

[0125] In one embodiment of the present invention, skin reactions such as skin diseases and / or allergic reactions are prevented by reducing oxidative degradation, preferably by reducing lipid peroxidation. In one embodiment of the present invention, skin reactions such as skin diseases and / or allergic reactions are prevented by reducing lipid peroxidation caused by ultraviolet light. In one embodiment of the present invention, skin reactions such as skin diseases and / or allergic reactions are prevented by reducing aldehyde formation caused by ultraviolet light, preferably by reducing the formation of malondialdehyde.

[0126] In a preferred embodiment of the present invention, skin diseases and / or allergic reactions are prevented by reducing oxidative degradation, preferably by reducing lipid peroxidation, wherein the skin diseases and / or allergic reactions are caused by fragrances. In a preferred embodiment of the present invention, skin diseases and / or allergic reactions are prevented by reducing lipid peroxidation caused by ultraviolet light, wherein the skin diseases and / or allergic reactions are caused by fragrances. In a preferred embodiment of the present invention, skin diseases and / or allergic reactions are prevented by reducing aldehyde formation caused by ultraviolet light, preferably by reducing the formation of malondialdehyde, wherein the skin diseases and / or allergic reactions are caused by fragrances.

[0127] In another embodiment, the present invention relates to a photostable body care composition comprising diethylamino hydroxybenzoyl hexyl benzoate and at least one fragrance. It is understood that a photostable body care composition remains stable when exposed to ultraviolet light, and in particular, the compounds contained therein do not undergo degradation processes when exposed to ultraviolet light.

[0128] The present invention is further illustrated by the following examples. [Example]

[0129] method Electron spin resonance (ESR) measurements were carried out using a highly sensitive X-band benchtop electron spin resonance spectrometer MiniScope MS300 supplied by Magnettech GmbH (Berlin, Germany).

[0130] UV irradiation of the samples was carried out using a xenon arc lamp solar simulator, Newport-ORIEL product line 81260 (Newport Solar Simulator - Product Specifications, USA), equipped with a 300 W xenon lamp.

[0131] 2,2,5,5-Tetramethylpyrrolidine N-oxyl was purchased from Merck. Synthetic sebum was purchased from wfk Testgewebe GmbH (Brügen, Germany).

[0132] Example 1: Quantification of free radicals generated in a formulation containing fragrance

[0133] To measure free radical generation in the formulations after UV irradiation, the concentration of a photostable spin marker added to the test samples was followed by electron spin resonance (ESR) spectroscopy before and after UV irradiation of the test samples. This photostable spin marker reacts rapidly with the free radicals generated in the formulations after UV irradiation.

[0134] The formulation incorporated 0.1% (w / w) of the fragrance to be tested (compare Table 1). The formulation was then diluted with distilled water (1:10 dilution factor) and an aqueous solution of the spin marker PCA (2,2,5,5-tetramethylpyrrolidine N-oxyl) was added to obtain a spin marker concentration of 0.01 mM. Knowing the concentration of spin trap PCA in the formulation, the amount of PCA lost was calculated. Samples were inserted into capillary quartz tubes and ESR measurements were performed before and after 20 minutes of UV irradiation. The irradiance as an integral over the spectral range of the solar simulator was E = 23.5 W / m for UVB; 2 , 180W / m for UVA 2 It was.

[0135] The percentage of UV-induced free radicals in formulations containing the test fragrances is shown in Table 1.

[0136] [Table 1]

[0137] Example 2: Effect of UV filter systems to reduce fragrance-induced sebum oxidation

[0138] Squalene in sebum is highly susceptible to oxidation. Squalene by-products in the form of peroxides affect cellular and tissue physiology. In this lipid oxidative degradation, free radicals steal electrons from lipids. Lipid peroxidation forms reactive aldehydes, such as malondialdehyde (MDA), as natural by-products, which can be used as markers of lipid peroxidation to assess oxidative damage.

[0139] Based on this principle, the following in vitro method was developed to evaluate sebum lipid oxidation.

[0140] The test formulations were prepared as follows.

[0141] The ingredients for Part A and the ingredients for Part B provided in Tables 2.1, 2.2, 2.3, and 2.4 below for each test sunscreen composition were combined and heated to 80°C, whereupon Part A was added to Part B under stirring and homogenized. The compositions were then cooled to room temperature under stirring. Parts C, D, and E, if present, were added under stirring, and the pH of each composition was adjusted to 5.5-7.00 with NaOH (30%), as needed.

[0142] The remaining fragrances in Table 1 were incorporated into formulations according to Table 2.1.

[0143] [Table 2-1] [Table 2-2] [Table 2-3] [Table 2-4] [Table 2-5] [Table 2-6]

[0144] The test formulation was applied at 2 mg / cm2 onto an artificial sebum film in a Petri dish. 2 The formulation film was applied in an amount of 1.25 mW / cm. A sebum film was first prepared by adding 1 g of synthetic sebum to 100 mL of heptane to obtain a sebum solution. 1 mL of this sebum solution was deposited on a Petri dish (6 cm diameter) and placed in a nitrogen chamber until the solvent had completely evaporated. The formulation film was dried in the nitrogen chamber and then irradiated with 1.25 mW / cm. 2 The samples were exposed to UVA for 2 hours.

[0145] Sebum was collected by adding heptane to a Petri dish and dissolving the sebum film using an ultrasonic bath. Finally, the MDA level, which corresponds to the oxidation product derived from sebum, was determined using the TBARS (thiobarbituric acid reactive substances) method. MDA in the sample was reacted with thiobarbituric acid (TBA) to produce the MDA-TBA adduct. The MDA-TBA adduct was quantified colorimetrically at 532 nm.

[0146] In this regard, 0.3 mL of sebum sample solution, 0.2 mL of 8 weight % (w%) SDS solution, 1.5 mL of 20 volume % (v%) acetic acid, 1.5 mL of TBA solution, and 0.5 mL of DI water were added to a tub, and the mixture was then heated at 95°C for 60 minutes, cooled to room temperature in an ice bath for 15 minutes, and centrifuged at 3000 rpm for 5 minutes. The absorbance of the reaction solution was measured at 532 nm using a UV spectrophotometer to detect the presence of TBA-MDA adducts.

[0147] [Table 3] TIFF0007819107000010.tif96170

[0148] As can be seen from Table 3, the lowest MDA levels are obtained when the formulation contains DHHB.

Claims

1. Use of diethylamino hydroxybenzoyl hexyl benzoate in an anti-aging care composition containing at least one fragrance to reduce oxidative degradation caused by UV radiation.

2. 10. The use according to claim 1 for reducing lipid peroxidation.

3. 3. Use according to claim 1 or 2, wherein the anti-aging care composition further comprises butyl methoxydibenzoylmethane and / or at least one further UV filter.

4. At least one fragrance ingredient is limonene, citral, linalool, alpha-isomethyl ionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert.-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amyl cinnamaldehyde, alpha-methyl ionone, amyl C-butylphenyl methylpropional cinnamal, amyl salicylate, amyl cinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, orange oil, bitter orange 4. The use according to any one of claims 1 to 3, wherein the active ingredient is selected from the group consisting of citronellol, butylphenyl methylpropional, cardamom oil, cedrol, cinnamaldehyde, cinnamyl alcohol, citronellyl methyl crotonate, lemon oil, coumarin, diethylsuccinate, ethyl linalool, eugenol, evernia furfuracea extract, evernia prunastri extract, farnesol, guaiac wood oil, hexyl cinnamal, hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linalyl acetate, mandarin oil, menthyl PCA, methylheptenone, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, vanillin, and mixtures thereof.

5. 4. The use according to any one of claims 1 to 3, wherein the at least one fragrance is selected from the group consisting of geraniol, linalool, alpha-isomethyl ionone, citral, coumarin, citronellol, benzyl salicylate, hexyl cinnamaldehyde, vanillin, orange oil, benzyl alcohol, bergamot oil, cinnamaldehyde, and mixtures thereof.

6. Use according to any one of claims 1 to 5, wherein the anti-aging care composition comprises hexyl cinnamaldehyde, diethylamino hydroxybenzoyl hexyl benzoate, optionally butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

7. Use according to any one of claims 1 to 5, wherein the anti-aging care composition comprises at least one fragrance, diethylamino hydroxybenzoyl hexyl benzoate, butyl methoxydibenzoylmethane, and optionally at least one further UV filter.

8. The anti-aging care composition at least one fragrance in an amount of 0.00001 to 1% by weight relative to the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 10% by weight relative to the total weight of the anti-aging care composition; Optionally, butyl methoxydibenzoylmethane in an amount of 0.1 to 5% by weight relative to the total weight of the anti-aging care composition; and Optionally, at least one further UV filter in an amount of 0.1 to 10% by weight relative to the total weight of the anti-aging care composition. The use according to any one of claims 1 to 7, comprising:

9. An anti-aging care composition comprising: at least one fragrance in an amount of 0.001 to 0.5% by weight, relative to the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition; Optionally, butyl methoxydibenzoylmethane in an amount of 0.1 to 4% by weight relative to the total weight of the anti-aging care composition; and Optionally, at least one further UV filter in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition. The use according to any one of claims 1 to 8, comprising:

10. The anti-aging care composition at least one fragrance in an amount of 0.001 to 0.5% by weight, relative to the total weight of the anti-aging care composition; diethylaminohydroxybenzoylhexylbenzoate in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition; butyl methoxydibenzoylmethane in an amount of 0.1 to 4% by weight relative to the total weight of the anti-aging care composition; Optionally, at least one further UV filter in an amount of 0.1 to 8% by weight relative to the total weight of the anti-aging care composition. The use according to any one of claims 1 to 9, comprising:

11. Use according to any one of claims 1 to 10, wherein the anti-aging care composition further comprises a dermatologically acceptable emulsifier, thickener and / or emollient.

12. Use according to any one of claims 1 to 11, wherein the anti-aging care composition is free of polyethylene glycol and polypropylene glycol and / or free of ethylhexyl methoxycinnamate and octocrylene.

13. Use according to any one of claims 1 to 12 for reducing lipid peroxidation caused by ultraviolet light.

14. Use according to any one of claims 1 to 13 for reducing aldehyde formation caused by ultraviolet light.

15. A body care composition comprising diethylaminohydroxybenzoylhexyl benzoate and at least one fragrance for use in a method for preventing skin conditions and / or allergic reactions caused by fragrances.

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