Deworming collar

Abstract

To provide an anthelmintic collar compatible with a peculiar release behavior of an insect pest control component, in which the pest control component can be further restrained from bleeding from the collar within an airtight container such as a blister packaging container and in which the pest control component rapidly bleeds from immediately after its use is started by taking out it from the airtight container.SOLUTION: An anthelmintic collar contains a vinyl chloride-based resin component, phenothrin, a transpiratory plasticizer and titanium dioxide.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an antiparasitic collar.

[0002] Antiparasitic collars have been developed that are molded from resin components containing pest-control ingredients to eliminate pests such as fleas and mites that infest pets such as dogs and cats. Immediately after production, antiparasitic collars are stored in airtight containers such as transparent blister packs, and after transportation, they are displayed in stores. (Patent Document 1)

[0003] When an anti-parasitic collar is stored in a sealed container, the pest-control ingredient does not bleed from the surface of the collar, but as soon as the sealed container is opened and the collar is put into use, a sufficient amount of the pest-control ingredient bleeds from the surface of the collar without delay, thereby exerting a pest-control effect.In other words, the pest-control ingredient must have a unique, contradictory release behavior. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2006-69591 Summary of the Invention [Problem to be solved by the invention]

[0005] Although antiparasitic collars have been developed to provide the unique release behavior of pest-controlling ingredients required for antiparasitic collars, depending on storage conditions, bleeding of the pest-controlling ingredients can occur even in sealed containers.

[0006] Because blister packaging containers are transparent, they have the advantage of allowing the packaged anthelmintic collar to be easily seen. However, if droplets caused by bleeding of the pest control ingredients are found on the surface of the anthelmintic collar, this can reduce the product value.

[0007] The present invention aims to provide an anti-parasitic collar that is compatible with the unique release behavior of pest control ingredients, in that the bleeding of the pest control ingredients from the collar can be further suppressed when placed in a sealed container such as a blister pack, and the pest control ingredients quickly bleed immediately after removal from the sealed container and use begins.

[0008] The present inventors have conducted extensive research to solve the above problems and have arrived at the present invention. [1] An anthelmintic collar containing a vinyl chloride resin component, fenothrin, a vaporizable plasticizer, and titanium dioxide. [2] The anthelmintic collar, wherein the content of titanium dioxide is 0.03% by weight to 10.00% by weight based on the total content of fenothrin and the volatile plasticizer. [3] The anthelmintic collar housed in a blister packing container. to provide. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide an anti-parasitic collar that can further suppress bleeding of pest control ingredients from the collar when placed in a sealed container such as a blister pack, and that is compatible with the unique release behavior of pest control ingredients, in which the pest control ingredients bleed quickly immediately after removal from the sealed container and use begins. DETAILED DESCRIPTION OF THE INVENTION

[0010] The vinyl chloride resin component used in the anthelmintic collar of the present invention is preferably ZEST (registered trademark) 1300Z (manufactured by Shin-Dai-ichi Vinyl Corporation), which has good compatibility with fenothrin and excellent flexibility.

[0011] The pest control ingredient used in the anthelmintic collar of the present invention is fenothrin. Fenothrin is blended in an amount equal to or greater than the saturated solubility amount in the vinyl chloride resin component. The content of fenothrin is usually component 20 to 60 Weight % range is.

[0012] The volatile plasticizers used in the anthelmintic collar of the present invention include esters, alcohols, ketones, and essential oils of animals and plants that are liquid at room temperature. Examples of liquid esters include phthalates, linear dibasic acid esters, and phosphate esters. Of these, phosphate esters such as triethyl phosphate and tributyl phosphate are preferred.

[0013] The titanium dioxide used in the anthelmintic collar of the present invention includes rutile titanium dioxide and anatase titanium dioxide, of which rutile titanium dioxide is preferred. The average particle size of the titanium dioxide used is typically in the range of 0.1 to 1.0 μm. Here, the average particle size refers to the particle size at 50% cumulative volume (D50) of the particle size distribution measured by laser diffraction using a laser diffraction particle size distribution analyzer (product name "MicrotracHRA9320-X100", Nikkiso Co., Ltd.).

[0014] The titanium dioxide content is 0.03% to 10.00% by weight of the total content of fenothrin and volatile plasticizer. This range further inhibits bleeding of the pest-control ingredient from the collar in a sealed container such as a blister pack, while allowing the pest-control ingredient to bleed quickly immediately after removal from the sealed container and use. Furthermore, by setting the titanium dioxide content to 0.30% to 3.00% by weight of the total content of fenothrin and volatile plasticizer, bleeding of the pest-control ingredient immediately after use is more rapid.

[0015] The anthelmintic collar of the present invention may contain an insect growth regulator as an active ingredient other than fenothrin, such as pyriproxyfen or bistrifluron.

[0016] The anthelmintic collar of the present invention may further contain a potentiator of fenothrin, such as piperonyl butoxide or MGK-264.

[0017] The anthelmintic collar of the present invention may also contain bleeding promoters, plasticizers other than volatile plasticizers, stabilizers, dyes, and the like.

[0018] Examples of the bleeding accelerator include erucic acid, carboxylic acid, etc. Examples of the carboxylic acid include fatty acids such as lauric acid, myristic acid, palmitic acid, and stearic acid, aromatic carboxylic acids such as benzoic acid, dicarboxylic acids such as tartaric acid and fumaric acid, and tricarboxylic acids such as citric acid.

[0019] Plasticizers other than volatile plasticizers are plasticizers having a vapor pressure of less than 0.0001 mmHg at 20° C., and examples thereof include diisononyl adipate, azelaic acid, 2-ethylhexyl, and sebacic acid.

[0020] Stabilizers include epoxidized soybean oil, barium / zinc liquid stabilizers, barium stearate, and the like.

[0021] The anthelmintic collar and blister packaging container of the present invention can be prepared by known techniques such as those described in Patent Document 1. For example, the anthelmintic collar can be produced by melt-kneading the various components described above in a known kneading machine such as a Plastograph Mill, Banbury Mixer, or Super Mixer, molding the mixture into a predetermined shape using a known injection molding machine such as an injection molder, extrusion molder, or press molder, and then cutting the mixture as necessary and attaching fasteners such as buckles.

[0022] Immediately after production, the anthelmintic collar of the present invention is housed in a blister packaging container 1 consisting of a mount 3 and a transparent blister member 4 as shown in Figure 1, and is then stored, transported, etc., and displayed in stores.

[0023] The mount 3 has a three-layer structure consisting of a paper substrate 5, a gas barrier layer 6, and a polyolefin layer 7 laminated in this order. Examples of paper substrates include coated cardboard, carton paper, and manila cardboard. Examples of gas barrier layers include aluminum and polyethylene terephthalate. Examples of polyolefin layers include L-LDPE. The paper substrate and gas barrier layer, as well as the gas barrier layer and polyolefin layer, are bonded together with an adhesive whose main components are vinyl acetate resin, ethylene-vinyl acetate copolymer resin, acrylic resin, or the like, to form a three-layer mount.

[0024] Blister element 4 is composed of a storage section 4a for storing the anthelmintic collar and a flat flange 4b ​​formed along the outer periphery of the storage section. This flange 4b ​​has an adhesive section 4d that can be pressed against a backing to keep storage section 4a airtight, and a handle 4c that allows the blister element to be peeled off from the backing without adhering to it.

[0025] The blister member 4 is made of a thermoplastic resin having gas barrier properties and optical transparency, and has a structure in which a film layer 8 and a PET layer 9 are bonded and laminated. The film layer is a layer that provides ease of peeling from the polyolefin layer on the mount, and can be, for example, TAF610C manufactured by Tocello Co., Ltd. The outermost PET layer is a layer that provides gas barrier properties, and can be, for example, PT-700 manufactured by Polytec Co., Ltd.

[0026] After the antiparasitic collar of the present invention is stored in the storage section 4a of the blister member, the collar is heat-pressed to thermally bond the film layer 8 of the blister member 4 to the polyolefin layer 7 of the backing paper 3. This allows the antiparasitic collar to be stored in a sealed state within the blister packaging container.

[0027] Examples of pests that can be controlled by the anthelmintic collar of the present invention include Siphonaptera pests such as cat fleas, dog fleas, and human fleas; Acari pests of the tick family such as Haemaphysalis longicornis, Haemaphysalis flava, Ixodes ova, and Ixodes sulcatus; and Diptera pests such as Aedes albopictus, Culex pipiens, Aedes aegypti, and Culex pipiens molestus. [Example]

[0028] The present invention will be specifically explained below with reference to examples, but the present invention is not limited to these examples.

[0029] Thirteen anthelmintic collars were produced using the ingredients listed below, the formulation shown in Table 1, and the anthelmintic collar manufacturing procedure described below. The values ​​shown in Table 1 are in weight percent.

[0030] [Raw materials used] Raw material component (A): Fenothrin (manufactured by Sumitomo Chemical Co., Ltd., trade name: Sumithrin) Raw material ingredient (B): Pyriproxyfen (manufactured by Sumitomo Chemical Co., Ltd., product name: Sumilab) Raw material component (C): Triethyl phosphate (Kurokane Chemical Co., Ltd., product name: TEP) Raw material component (D): Diisodecyl adipate (Taoka Chemical Co., Ltd., trade name: DIDA) Ingredient (E): Isostearic acid (Nissan Chemical Industries, Ltd.) Raw material component (F): Epoxidized soybean oil (ADEKA Corporation, product name: Adekaiser O-130P) Ingredient (G): Barium / zinc liquid stabilizer (Sakai Chemical Industry, product name: LBZ-793K) Raw material component (H): Rutile titanium dioxide (manufactured by Teika Corporation, product name JR800, average particle size 0.27 μm) Raw material component (I): Barium stearate (NOF Corporation, product name: Barium stearate) Raw material component (J) Vinyl chloride resin (manufactured by Shin-Daiichi Vinyl Corporation, product name: ZEST 1300Z)

[0031] [Table 1] TIFF0007825254000001.tif75131

[0032] [Deworming collar manufacturing procedure] 1. After raw material components (F) and (G) were heated to 60°C in advance, all raw material components (A) to (G) were mixed in a plastic cup to obtain a mixed liquid. 2. Raw material components (H), (I) and (J) were mixed in a separate plastic cup until uniform, to obtain a mixed powder. 3. A Plastograph Mill (manufactured by Toyo Seiki Seisakusho, Ltd.) was heated to 140°C, and the mixed powder was added while the rotor was rotating at 10 rpm, followed by the mixed liquid. The rotor rotation speed was changed to 50 rpm, and the mixture was melt-kneaded for 5 minutes to obtain a kneaded product. 4. The kneaded product obtained above was removed from the Plastograph Mill, sandwiched between two aluminum plates, and pressed under a pressure of 50 kg / cm using a tabletop test press (manufactured by Shinto Metal Industries Co., Ltd.). 2 Press for 1 minute at 100 kg / cm 2 Pressed for 1 minute. 5. 27 g of the pressed product obtained above was placed in a molding frame measuring 15 cm in length, 5 cm in width, and 3 mm in thickness, and pressed in the tabletop test press at a temperature of 160°C and a pressure of 100 kg / cm. 2 The mixture was pressed for 1 minute under the above conditions to obtain a compact. 6. The molded body obtained above was transferred to the water-cooled part of a tabletop test press and pressed under a pressure of 100 kg / cm. 2 The molded body was cooled to 35°C under the above conditions, and then cut into a piece 15 cm long, 1 cm wide and 3 mm thick to obtain an anti-parasitic collar.

[0033] Ten of each of the anthelmintic collars obtained above were placed in the storage compartment of a blister pack having the shape shown in Figure 1. A backing was then placed on the blister pack, and the collar of the backing was heated and pressed to produce a blister pack containing the anthelmintic collars. The mount had a three-layer structure consisting of a 500 μm thick paper substrate made of coated cardboard, a 25 μm thick gas barrier layer made of polyethylene terephthalate, and a 30 μm thick polyolefin layer made of L-LDPE.The blister member had a two-layer structure consisting of a 25 μm thick film layer made of TAF610C and a 350 μm thick PET layer.

[0034] [Check for bleeding] The blister packaging container containing the obtained anthelmintic collar was placed in a thermostatic chamber at 60°C, and after two months it was removed and checked for the presence or absence of bleeding on the surface of the anthelmintic collar. The surface of the anthelmintic collar inside the blister pack was observed, and if droplets were found on the surface of the collar, it was judged as having bleeding, and if no droplets were found, it was judged as not having bleeding. Table 2 below shows the number of anthelmintic collars that had bleeding.

[0035] [Table 2] TIFF0007825254000002.tif1186

[0036] [Measurement of bleeding amount] Three of each anthelmintic collar prepared as described above were left in a 35°C incubator for 16 days, and fenothrin and pyriproxyfen that had bled onto the surface of the anthelmintic collar over time were wiped off with paper rags (Elleair® Prowipe Soft Wiper S200, manufactured by Daio Paper Co., Ltd.). After each elapsed time, the paper wipes and 50 ml of acetone were placed in a 60 ml screw tube and irradiated with ultrasound for 30 minutes to extract fenothrin and pyriproxyfen, yielding an extract. The fenothrin contained in the extract was measured by liquid chromatography under the following measurement conditions, and the amount of fenothrin (μg / cm 2 The results are shown in Table 3. The liquid chromatography measurement conditions are as follows. Mobile phase: Acetonitrile / distilled water mixture (80:20) Extraction volume: 5 μL Flow rate: 1.0mL / min Separation tube: Sumika Chemical Analysis Center ODS-A212 Detector: UV absorption spectrophotometer (Shimadzu Corporation) Detection wavelength: 272 nm

[0037] [Table 3] TIFF0007825254000003.tif2980 [Brief explanation of the drawings]

[0038] [Figure 1] FIG. 1 is a perspective view showing a blister pack and an antiparasitic collar of the present invention housed in the pack. [Figure 2] FIG. 2 is an explanatory view showing the blister packing container shown in FIG. 1 in the process of peeling the collar of the blister member from the backing to remove the antiparasitic collar stored in the blister packing container. [Figure 3] 2 is a cross-sectional view of the adhesive portion between the blister member and the backing sheet in the blister packaging container shown in FIG. 1. FIG. [Explanation of symbols]

[0039] 1 blister pack 2. Deworming collars 3 Mount 4 Blister member 4a Storage section 4b Collar 4c Handle 4d adhesive part 5 Paper base material 6 Gas barrier layer 7 Polyolefin layer 8 film layers 9 PET layers

Claims

1. An anthelmintic collar containing a vinyl chloride resin component, fenothrin, a volatile plasticizer, and titanium dioxide, The content of fenothrin is in the range of 20 to 60% by weight based on the vinyl chloride resin component, the content of titanium dioxide is 0.03% by weight to 3.00% by weight based on the total content of fenothrin and the volatile plasticizer; The antiparasitic collar is characterized in that it is stored in a sealed container.

2. 2. The anthelmintic collar according to claim 1, wherein the content of titanium dioxide is 0.30% by weight to 3.00% by weight based on the total content of fenothrin and said volatile plasticizer.

3. 3. The anthelmintic collar according to claim 1 or 2, wherein the sealed container is a blister pack.

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