Oral components

Abstract

To provide an oral composition with improved bitterness and irritation derived from cationic fungicides or condensed phosphates, with no unpleasant stickiness after use, and with good flavor expression and excellent usability.SOLUTION: The oral composition comprises (A) one or more selected from cationic disinfectants and condensed phosphates; (B) a high sweetening agent; (C) one or more selected from 6 to 12 carbon lactone, vanillin, ethyl vanillin, maltol, and ethyl maltol; and (D) two or more selected from caryophyllene, germacrene, and viridiflorol.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition in which bitterness and irritation derived from a cationic bactericide or condensed phosphate are improved and which has an excellent feeling in use.

Background Art

[0002] In oral compositions, the feeling in use is important for continuous use and improvement of effects, and masking of bitterness and irritation derived from compounding components to improve the feeling in use becomes an issue. As active ingredients for oral compositions, quaternary ammonium salts, particularly cationic bactericides having a high bactericidal effect, and condensed phosphates having an effect of suppressing stain adhesion to teeth have bitterness and irritation, and masking and improving these are important for ensuring the feeling in use.

[0003] On the other hand, as a flavor of oral compositions, a popular fruit-type flavor for children and young people is centered on flavor (compounded fragrance of single-component ingredients), so compared with a flavor imparting taste by natural essential oils such as spices and natural mint, an unpleasant taste derived from the base is likely to be directly felt.

[0004] Particularly in an oral composition containing cetylpyridinium chloride, there are significant issues regarding masking of bitterness and irritation, and masking techniques using sweeteners and the like have been utilized so far, and for example, Patent Documents 1 to 4 have been proposed. However, in an oral composition having a flavor with a weak cooling sensation such as a fruit type for children, since the taste-imparting property is weak, it is necessary to blend a masking component. Particularly in those with a weak cooling sensation, a sticky sweetness unique to the component used for masking accumulates in the oral cavity, and there are issues in improving the feeling in use. Patent Document 1 (Japanese Patent No. 5721973) describes how unpleasant tastes such as bitterness and irritation are eliminated by combining cetylpyridinium chloride with specific amounts of sucralose and xylitol. Patent Document 2 (Japanese Patent No. 3070152) describes how the bitterness derived from the antibacterial agent is masked and the taste is improved by combining a quaternary ammonium salt type cationic antibacterial agent with tranexamic acid and / or ε-aminocaproic acid and a stevia-based sweetener. Patent Document 3 (Japanese Patent No. 4044748) describes how the bitterness of cetylpyridinium chloride and tranexamic acid is masked by maltitol. Furthermore, Patent Document 4 (Japanese Patent No. 5398102) describes how the bitterness unique to cationic antibacterial agents is masked by combining trehalose, erythritol, or palatinite. [Prior art documents] [Patent Documents]

[0005] [Patent Document 1] Patent No. 5721973 [Patent Document 2] Patent No. 3070152 [Patent Document 3] Patent No. 4044748 [Patent Document 4] Patent No. 5398102 [Overview of the project] [Problems that the invention aims to solve]

[0006] The present invention has been made in view of the above circumstances, and aims to provide an oral composition that has improved bitterness and irritation derived from cationic disinfectants or condensed phosphates, and that offers superior usability. [Means for solving the problem]

[0007] The present inventors conducted diligent studies to achieve the above objectives and found that by combining an oral composition containing (A) one or more selected from cationic bactericides and condensed phosphates with (B) a high-intensity sweetener and (C) one or more selected from lactones with 6 to 12 carbon atoms, vanillin, ethyl vanillin, maltol, and ethyl maltol, and (D) two or more selected from caryophyllene, germacrene, and viridiflorol, the bitterness and irritation derived from component (A) are improved, bitterness and irritation are suppressed during and after use, no unique stickiness is felt after use, and the oral composition has good flavor expression during and after use, resulting in an oral composition with excellent usability. This led to the present invention.

[0008] In this invention, by combining component (A) with a combined system of components (B) and (C), the bitterness and irritation derived from component (A) are masked and improved by the combined system. Furthermore, by using two or three specific substances as component (D) and further combining component (D) with the above combined system, the unique stickiness (a sticky sweetness that remains in the mouth after use) caused by the combined system of components (B) and (C) is suppressed, resulting in an excellent user experience. In this case, when component (A) is combined with components (B) and (C), a distinctive stickiness after use becomes noticeable. However, by further combining it with component (D), the aforementioned stickiness is suppressed and not felt after use, and the bitterness and irritation caused by component (A) are significantly masked and improved. As a result, there is almost no bitterness or irritation felt during or after use, and the original flavor can be stably expressed. The oral composition of the present invention contains, for example, a relatively mild fragrance such as a fruit type (a fragrance mainly composed of single-ingredient blended fragrances), and even if the amount of cooling agents such as menthol is relatively small or absent, the combination of components (B), (C), and (D) with component (A) allows the medicinal effects of component (A) to be exerted while masking and suppressing the bitterness and irritation caused by component (A). Furthermore, even if a highly sweet component (B) is included, there is no unpleasant stickiness after use, resulting in a superior user experience. As shown in the comparative examples described below, when component (A) was included but component (B) or (C) was not included, the absence of bitterness and irritation after use was poor (Comparative Examples 2 and 3). Even when components (B) and (C) were included but component (D) was not included, the absence of stickiness after use was poor (Comparative Examples 1, 4-6). In Comparative Examples 4-6, even when only one of the specific substances of component (D) was included, the absence of stickiness after use was poor. In contrast, the oral compositions shown in the examples, which included component (A), components (B) and (C), and two or more specific substances as component (D), exhibited excellent absence of bitterness and irritation after use, as well as excellent flavor development during and after use.

[0009] Accordingly, the present invention provides the following oral compositions. [1] (A) One or more selected from cationic disinfectants and condensed phosphates, (B) High-intensity sweeteners, (C) One or more lactones with 6 to 12 carbon atoms selected from vanillin, ethyl vanillin, maltol, and ethyl maltol. and (D) Two or more selected from caryophyllene, germacrene, and viridiflorol An oral composition characterized by containing the following: [2] (A) The oral composition according to [1], wherein component (A) is selected from cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine, pyrophosphate, tripolyphosphate, and hexametaphosphate. [3] (B) The oral composition according to [1] or [2], wherein the high-intensity sweetener is one or more selected from sucralose, sodium saccharin, stevia, acesulfame potassium, aspartame, thaumatin, licorice, and glycyrrhizin. [4] The oral composition according to any one of [1] to [3], wherein component (C) is a lactone having 6 to 12 carbon atoms selected from γ-octaractone, γ-nonalactone, γ-decalactone, γ-undecalactone, and δ-dodecalactone. [5] The oral composition according to any one of [1] to [4], wherein component (D) is caryophyllene, germacrene, and viridiflorol, and the mass ratio of caryophyllene:germacrene:viridiflorol is 1:(1~2.5):(2~5). [6] An oral composition according to any one of [1] to [5], wherein if it contains a cationic bactericide, the content thereof is 0.005 to 0.3% by mass, and if it contains a condensed phosphate, the content thereof is 0.1 to 3% by mass. [7] An oral composition according to any one of [1] to [6], wherein the content of component (B) is 0.001 to 0.2% by mass, the content of component (C) is 0.00001 to 0.1% by mass, and the content of component (D) is 0.000005 to 0.05% by mass. [8] Furthermore, the oral composition according to any one of [1] to [7], wherein (E) it does not contain one or more selected from menthol and carvone, or it contains such a substance, but the amount is 0.05% by mass or less in the case of a mouthwash, and 0.5% by mass or less in the case of a toothpaste. [Effects of the Invention]

[0010] According to the present invention, there is provided an oral composition that improves the bitterness and irritation derived from component (A), does not feel a unique and unpleasant stickiness after use, has good flavor expressiveness, and excellent usability. The oral composition of the present invention gives a medicinal effect such as a bactericidal effect by component (A), and even if a fruit-type fragrance is used to make a fragrance with a relatively weak cooling feeling, the bitterness and irritation derived from component (A) are suppressed, the usability is good, and it is effective for children and young people who are sensitive to taste and irritation.

Mode for Carrying Out the Invention

[0011] Hereinafter, the present invention will be described in more detail. The oral composition of the present invention contains one or more selected from (A) a cationic bactericide and a condensed phosphate, (B) a high-intensity sweetener, (C) one or more selected from lactones having 6 to 12 carbon atoms, vanillin, ethyl vanillin, maltol, and ethyl maltol, and (D) two or more selected from caryophyllene, germacrene, and viridiflorol.

[0012] Component (A) is a cationic bactericide and / or a condensed phosphate. As active ingredients, the cationic bactericide has a bactericidal effect, and the condensed phosphate has an effect of suppressing the adhesion of stains to teeth, and both have bitterness and irritation. In the present invention, particularly when component (A) is a cationic bactericide, even if cetylpyridinium chloride, which has relatively strong bitterness and the like, is used, its own bitterness and irritation are masked, ensuring excellent usability and giving a high bactericidal effect.

[0013] Examples of the cationic bactericide include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine, and the like. These can be used alone or in combination of two or more, and commercially available products can also be used.

[0014] Examples of the condensed phosphates include linear polyphosphates such as pyrophosphoric acid, tripolyphosphoric acid, and tetraphosphoric acid, and cyclic polyphosphates such as trimeta - phosphoric acid, tetrameta - phosphoric acid, and hexameta - phosphoric acid. Examples of the salts include sodium salts and potassium salts, and sodium salts are particularly preferred. These can be used alone or in combination of two or more. Among them, pyrophosphates, tripolyphosphates, and hexameta - phosphates are preferred. Commercially available products such as those manufactured by Taihei Chemical Industry Co., Ltd. can be used as these condensed phosphates.

[0015] When a cationic bactericide is blended as the component (A), the blending amount is preferably 0.005 - 0.3% (mass%, the same hereinafter) of the whole composition, more preferably 0.01 - 0.1%. The higher the blending amount, the higher the bactericidal effect. However, when it is 0.3% or less, the bitterness and irritation of itself are sufficiently masked, and the flavor expressiveness is sufficiently ensured. When a condensed phosphate is blended as the component (A), the blending amount is preferably 0.1 - 3% of the whole composition, more preferably 0.1 - 2%. The higher the blending amount, the higher the effect of suppressing stain adhesion to teeth. However, when it is 3% or less, the bitterness and irritation of itself are sufficiently masked, the flavor expressiveness is sufficiently ensured, and a good appearance can be maintained.

[0016] (B) High - intensity sweeteners have the effect of masking and improving the bitterness and irritation derived from the component (A) when used in combination with the component (C). (B) High - intensity sweeteners can use sweeteners with a sweetness intensity of preferably 5 or more, more preferably 10 or more, and particularly preferably 50 or more when the sweetness of sucrose is set to 1. Examples of high - intensity sweeteners include sucralose, sodium saccharin, stevia, acesulfame potassium, aspartame, thaumatin, licorice, glycyrrhizin, etc. Particularly from the viewpoint of improving bitterness and irritation, sucralose, sodium saccharin, stevia, acesulfame potassium, and aspartame are preferred, more preferably sucralose, sodium saccharin, and even more preferably sucralose. These can be used individually or in combination of two or more, and commercially available products can be used; specifically, sucralose manufactured by San-Ei Gen F.F.I. Co., Ltd. can be used.

[0017] (B) The amount of high-intensity sweetener is preferably 0.001 to 0.2% of the total composition, and more preferably 0.005 to 0.1%. If the amount is 0.001% or more, bitterness and irritation are sufficiently improved, and if it is 0.2% or less, stickiness is sufficiently prevented, and the development of its own taste is prevented, while ensuring sufficient flavor development.

[0018] Component (C) is one or more selected from lactones with 6 to 12 carbon atoms, vanillin, ethyl vanillin, maltol, and ethyl maltol. Component (C), when used in combination with component (B), masks and improves the bitterness and irritation derived from component (A). It also stabilizes the flavor and contributes to ensuring flavor expression. As component (C), one or more can be used selected from (C-1) a lactone having 6 to 12 carbon atoms and / or (C-2) vanillin, ethyl vanillin, maltol, and ethyl maltol, but component (C-1) is particularly preferred, and the use of components (C-1) and (C-2) in combination is even more preferred.

[0019] (C-1) Lactones having 6 to 12 carbon atoms include, specifically, γ-hexalactone, δ-hexalactone, γ-heptalactone, γ-octaractone, δ-octaractone, γ-nonalactone, δ-nonalactone, γ-decalactone, δ-decalactone, γ-undecalactone, δ-undecalactone, γ-dodecalactone, δ-dodecalactone, etc., with γ-octaractone, γ-nonalactone, γ-decalactone, γ-undecalactone, and δ-dodecalactone being particularly preferred, and more preferably γ-decalactone, γ-undecalactone, δ-dodecalactone, and even more preferably γ-undecalactone. These can be used individually or in combination of two or more types, and commercially available products from manufacturers such as Soda Perfumery Co., Ltd. and Takasago International Corporation can also be used.

[0020] The (C-2) component is vanillin, ethyl vanillin, maltol, or ethyl maltol, and one of these can be used alone or in combination of two or more. (C-2) The components can be commercially available products. For example, vanillin can be manufactured by Toyotama Fragrance Co., Ltd., ethyl vanillin by Taiyo Fragrance Co., Ltd., maltol by Inoue Fragrance Co., Ltd., and ethyl maltol by PFIZER Corporation.

[0021] (C) The amount of component is preferably 0.00001 to 0.1% of the total composition. (C) When a lactone with 6 to 12 carbon atoms (C-1) is included as component (C), the amount included is preferably 0.0002 to 0.1% of the total composition, more preferably 0.001 to 0.05%, and even more preferably 0.001 to 0.03%. If the amount included is 0.0002% or more, bitterness and irritation are sufficiently improved, and if it is 0.1% or less, stickiness is sufficiently prevented, and the development of its own taste is prevented, while ensuring sufficient flavor development. When component (C-2) is included as component (C), the amount included is preferably 0.00001 to 0.01% of the total composition, more preferably 0.00005 to 0.006%, and even more preferably 0.0001 to 0.003%. If the amount included is 0.00001% or more, bitterness and irritation are sufficiently improved, and if it is 0.01% or less, stickiness is sufficiently prevented, and the development of its own taste is also prevented, while sufficient flavor development can be ensured.

[0022] (D) The components are caryophyllene, germacrene, and viridiflorol, and it is preferable to use two or more selected from these, with a combination of three being desirable. Component (D), when combined with components (B) and (C), has the effect of improving the stickiness (a sticky sweetness that remains in the mouth after use) caused by the combined use of components (B) and (C), thereby suppressing stickiness and improving bitterness and irritation. Furthermore, if any of caryophyllene, germacrene, or viridiflor is used alone in place of component (D), the stickiness after use will not improve, and the effects of the present invention will not be obtained.

[0023] (D) The composition ratio of component (D) is not particularly limited as long as it contains at least two of the substances caryophyllene, germacrene, and viridiflorol. However, when using caryophyllene, germacrene, and viridiflorol, the mass ratio of caryophyllene:germacrene:viridiflorol is preferably 1:(1~2.5):(2~5), and more preferably 1:(1~2):(2~3). Furthermore, when caryophyllene and germacrene are combined, the caryophyllene:germacrene (mass ratio) is preferably 1:(1-2), when caryophyllene and viridiflorol are combined, the caryophyllene:viridiflorol (mass ratio) is preferably 1:(2-3), and when germacrene and viridiflorol are combined, the germacrene:viridiflorol (mass ratio) is preferably (1-2):(2-3). When blended in this ratio, the stickiness is further improved.

[0024] (D) The components can be formulated as individual fragrance materials, such as caryophyllene, germacrene, and viridiflorol, but they can also be formulated as extracts of essential oils or other substances containing each of these substances. Caryophyllene, germacrene, and viridiflor may be obtained by extraction from natural products, chemical synthesis, or a combination of natural and chemically synthesized forms. (D) Component can be a commercially available product, specifically, commercially available products such as caryophyllene-BE (manufactured by Inoue Fragrance Manufacturing Co., Ltd.), germacrene D (manufactured by Toronto Research, Inc.), and viridiflorol (manufactured by Toronto Research, Inc.) can be used.

[0025] Examples of extracts of essential oils, etc., mentioned above include peppermint oil containing caryophyllene, germacrene, and viridiflorol; Japanese mint oil containing caryophyllene and germacrene; spearmint oil containing caryophyllene and viridiflorol; and artificial mint oil containing caryophyllene, germacrene, and viridiflorol. These can be extracted from plants of the genus Mentha of the Lamiaceae family by known methods such as distillation.

[0026] Specifically, as the extract, a composition containing caryophyllene, germacrene, and viridiflor obtained by the manufacturing method described in Japanese Patent Application No. 2020-087507 and Japanese Patent Application No. 2020-087508 can be used, and a product manufactured by the following method can be used. Oil (essential oil) derived from plants of the genus Mentha in the Lamiaceae family is precisely distilled at a pressure of 0.00001 to 0.05 bar, preferably 0.002 to 0.04 bar, more preferably 0.004 to 0.03 bar, at a temperature of 40 to 250°C, preferably 60 to 180°C, more preferably 80 to 140°C, to recover 75 to 97%, preferably 92 to 96% of the total amount of oil derived from plants of the genus Mentha in the Lamiaceae family as volatile part A, and a distillation residue consisting of 3 to 25%, preferably 4 to 8% of the total amount of oil derived from plants of the genus Mentha in the Lamiaceae family as non-volatile part A is obtained, and this distillation residue is obtained by thin-film distillation, and contains a volatile fraction (first volatile fraction) consisting of volatile part B which accounts for 5 to 50%, preferably 10 to 30% of the total amount of distillation residue, or consists of said volatile fraction. The conditions for precision distillation to obtain volatile portion A are preferably a pressure of 0.002 to 0.04 bar and a temperature of 60 to 180°C, and more preferably a pressure of 0.004 to 0.03 bar and a temperature of 80 to 140°C. By precision distillation under these conditions, the above-mentioned component (D) (caryophyllene, germacrene, viridiflorol) can be concentrated in the distillation residue. Furthermore, the conditions for distillation to obtain the volatile fraction (first volatile fraction) are preferably a temperature of 90 to 180°C and a pressure of 0.00001 to 0.01 bar, and more preferably a temperature of 140 to 160°C and a pressure of 0.002 to 0.008 bar. Furthermore, it is more preferable that the product consists of a second volatile fraction, which is obtained by further thin-film distillation of volatile fraction B, and comprises 50-95%, preferably 60-95%, and more preferably 60-90% of the total amount of volatile fraction B, in the form of volatile fraction C. The distillation conditions for obtaining the second volatile fraction are preferably 90-180°C and a pressure of 0.00001-0.01 bar, and more preferably 140-160°C and a pressure of 0.002-0.008 bar. Compared to the first volatile fraction, the second volatile fraction has components such as resin that contribute more to off-flavors removed. The extract of the Mentha genus of the Lamiaceae family obtained in this way preferably contains a total of 15-50%, particularly 20-40%, and especially 30-40% of component (D) (caryophyllene, germacrene, and viridiflorol), and the quantitative ratio (mass ratio) of the three substances is within the above range.

[0027] The amount of component (D) is preferably 0.000005 to 0.05% of the total composition. Furthermore, when the oral composition is a mouthwash, the amount of component (D) is preferably 0.000005 to 0.05% of the total composition, more preferably 0.00001 to 0.01%, even more preferably 0.00005 to 0.001%, and most preferably 0.0001 to 0.0005%. If the amount is 0.000005% or more, stickiness is sufficiently improved, and if it is 0.05% or less, flavor expression can be sufficiently ensured. Furthermore, when the oral composition is a toothpaste, the amount of component (D) is preferably 0.00005 to 0.05% of the total composition, more preferably 0.0001 to 0.01%, even more preferably 0.0005 to 0.01%, and most preferably 0.001 to 0.005%. If the amount is 0.00005% or more, stickiness is sufficiently improved, and if it is 0.05% or less, flavor expression can be sufficiently ensured.

[0028] The oral composition of the present invention may further contain (E) menthol and / or carvone. These are cooling agents that provide a refreshing sensation. Menthol and carvone can be commercially available products, specifically L-menthol (manufactured by Takasago International Corporation) and L-carvone (manufactured by Shiono International Corporation), etc. They can also be incorporated as essential oils, or as extracts of the above-mentioned plants together with component (D).

[0029] The amount of component (E) is preferably 0.05% or less of the total composition, particularly 0.03% or less, but may also be 0.02% or less, or even 0% when the oral composition is a mouthwash. Furthermore, the amount of component (E) is preferably 0.5% or less of the total composition, particularly 0.3% or less, but may also be 0% when the oral composition is a toothpaste. In oral compositions, generally, the less a refreshing sensation is felt, the less a refreshing sensation is felt. However, in the oral composition of the present invention, even if the amount of component (E) is relatively small, as described above, and even if it is an amount that does not cause an overly strong refreshing sensation for people who are sensitive to irritation, such as children, or even if component (E) is not included, the bitterness and irritation derived from component (A) are masked and improved, stickiness is prevented, a refreshing sensation is provided, and the user experience is excellent.

[0030] The oral composition of the present invention can be used as a toothpaste, mouthwash, mouth spray, topical application, patch, etc. Among these, toothpaste, mouthwash, and mouthwash are preferred, and more preferably toothpaste and mouthwash, with mouthwash being particularly preferred. In this case, in addition to the above components, other optional components can be appropriately added depending on the application and dosage form, as long as they do not interfere with the effects of the present invention. Specifically, mouthwashes may contain surfactants, humectants, solvents, pH adjusters, and, if necessary, sweeteners, thickeners, suspending agents, preservatives, colorants, fragrances, and various active ingredients. Furthermore, toothpaste, especially paste toothpaste, may contain abrasives, surfactants, binders, viscosity enhancers, and, if necessary, sweeteners, preservatives, colorants, fragrances, and various active ingredients. Specifically, the following can be used.

[0031] The surfactant can be one or more known surfactants for oral use, such as anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants, and can be blended individually or in combination of two or more. Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, dodecylbenzenesulfonates, α-sulfo fatty acid alkyl esters, and alkyl phosphate esters. Sodium salts and potassium salts are preferred as the salts. Examples of cationic surfactants include alkylammonium salts and alkylbenzylammonium salts. Examples of nonionic surfactants include polyoxyethylene (POE) hydrogenated castor oil, polyoxyethylene alkyl ethers, polyglycerin fatty acid esters, sugar fatty acid esters, sorbitan fatty acid esters, polyoxyethylene polyoxypropylene block copolymer type nonionic surfactants, polyoxyethylene fatty acid esters, and fatty acid monoglycerides. Examples of amphoteric surfactants include betaine-type surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine, imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts, and amino acid-type surfactants such as N-fatty acid acyl-L-alginate salts.

[0032] Examples of humectants include glycerin, propylene glycol, ethylene glycol, polyethylene glycol, and sodium pyrrolidone carboxylate. These humectants can be used individually or in combination of two or more.

[0033] In addition to purified water, lower monohydric alcohols such as ethanol can be used as solvents. Examples of pH adjusting agents include organic acids such as citric acid and lactic acid, their salts, hydrochloric acid, inorganic acids such as sodium hydroxide, potassium hydroxide, sodium dihydrogen phosphate, and disodium hydrogen phosphate, and inorganic base compounds. The preferred pH of the oral composition of the present invention is 5 to 9 (at 25°C).

[0034] Suitable sweeteners include those with a sweetness level of less than 5 when sucrose (table sugar) is set to 1, and can be incorporated within a range that does not impair the effects of the present invention. Examples include sugar alcohols such as xylitol, sorbitol, mannitol, maltitol, and erythritol.

[0035] Examples of thickening agents include xanthan gum, sodium alginate, alginate esters, polyvinyl alcohol, hydroxyethylcellulose, carrageenan, sodium carboxymethylcellulose, polyvinylpyrrolidone, sodium polyacrylate, and sodium polyglutamate (natto bacteria gum). These thickening agents can be used individually or in combination of two or more.

[0036] Examples of suspending agents include emulsions in which the oily component consists of one or more oils selected from olive oil, camellia oil, castor oil, and triglycerides with 6 to 12 carbon atoms in the fatty acid. As this emulsion, an O / W (oil-in-water) emulsion can be used, obtained by emulsifying the oily component with an emulsifier using a polyhydric alcohol such as glycerin or propylene glycol and water as the dispersion medium. In this case, if the oral composition is a liquid, the oil droplet particles of the O / W emulsion are dispersed in the liquid oral composition, and the dispersion medium is integrated and dissolved in the aqueous phase of the liquid oral composition, existing as an O / W emulsion. Nonionic surfactants such as glycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ethers can be used as emulsifiers. Known methods can be used to prepare the emulsion. For example, an O / W type emulsion can be prepared by stirring a predetermined amount of nonionic surfactant, a polyhydric alcohol dispersion medium, and half the amount of water in a homomixer, then adding the oily component to form an emulsion, and finally adding the remaining water. The average particle size of the prepared emulsion can then be adjusted using a high-pressure homogenizer.

[0037] Examples of preservatives include parahydroxybenzoic acid esters such as methyl parahydroxybenzoate, and benzoate salts such as sodium benzoate. Suitable colorants include highly safe, water-soluble pigments such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105. Additionally, food colorings such as Brilliant Blue and Tartrazine, as well as the pigment titanium dioxide, can also be used as colorants.

[0038] Fragrances include, for example, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, cardamom oil, coriander oil, orange oil, lemon oil, mandarin oil, lime oil, grapefruit oil, yuzu oil, lavender oil, rosemary oil, laurel oil, perilla oil, chamomile oil, spearmint oil, peppermint oil, Japanese mint oil, caraway oil, marjoram oil, celery oil, bay oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, patchouli oil, paracleth oil, and iris oil. Natural fragrances such as concrete, rose absolute, orange blossom absolute, vanilla absolute, lavender absolute, patchouli absolute, and other natural fragrances, as well as fragrances obtained by processing these natural fragrances (pre-distillation cutting, post-distillation cutting, fractional distillation, liquid-liquid extraction, essence production, powder production, etc.), and limonene, pinene, butanol, isoamyl alcohol, hexenol, linalool, anethole, thymol, eugenol, menthone, pulegone, fencone, cineole, hexanal, octanal, anisamine Individual fragrances such as aldehyde, cinnamic aldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, linalyl acetate, menthyl acetate, carbyl acetate, phenoxyethyl isobutyrate, methyl epijasmonate, methyl salicylate, ethyl salicylate, methyl anthranilate, ethyl methylphenyl glycidate, ethyl lactate, ambrettelide, dimethyl sulfide, trimethylpyrazine, ethyl thioacetate, vanillyl butyl ether, piperine, capsaicin, gingerol, and spiranthol, as well as blended fragrances such as strawberry, apple, banana, pineapple, grape, mango, plum, orange, lemon, yuzu, grapefruit, butter, milk, white floral, rose, and black tea, can be used in combination with other known fragrance materials used in oral compositions. The amount of these fragrance materials used is not particularly limited, but it is preferable to use them in an oral composition at a concentration of 0.000001 to 1%.Furthermore, it is preferable to use the above-mentioned fragrance material as a fragrance in an oral composition at an amount of 0.01 to 2.0%. Furthermore, if the fragrance contains component (C) or (D), the amount of component (C) or (D) can be used within the above range, and if it contains component (E), the amount of component (E) can be used within the above range.

[0039] Any active ingredients that can be included are fluorides such as sodium fluoride, sodium monofluorophosphate, and stannous fluoride; enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, allantoin, aluminum chlorohydroxyallantoin, azulene, glycyrrhizinate, glycyrrhetinate, sodium chloride, and vitamins; bactericidal agents such as isopropylmethylphenol (Biozol), thymol, copper chlorophyll, copper gluconate, hinokitiol, and lysozyme chloride; tartar preventatives such as zeolite; blood circulation promoters such as vitamin E; and amino acids such as alanine, glycine, and proline. The amount of these active ingredients included can be an effective amount within a range that does not hinder the effects of the present invention.

[0040] Furthermore, the following can also be used as toothpaste. Examples of abrasives include silica-based abrasives such as crystalline silica, amorphous silica, silica gel, and aluminosilicate, as well as zeolites, anhydrous calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, trimagnesium phosphate, zirconium silicate, tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, and synthetic resin-based abrasives. The amount of abrasive material is typically 5-70% of the total composition, and especially 10-50%.

[0041] As a viscous agent, substances such as those listed above as wetting agents, or sugar alcohols such as sorbitol, xylitol, and erythritol, which can also be used as sweeteners, can be used. The amount of viscous agent is usually 0-70%, particularly 3-50%, of the total composition.

[0042] Organic or inorganic binders can be used as the binder. Specifically, examples of organic binders include the substances listed above as thickeners, and examples of inorganic binders include gelling (thickening) silica and gelling (thickening) aluminum silica. The amount of binder is usually 0.1 to 10%, particularly 0.1 to 5%, of the total composition. [Examples]

[0043] The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In the following examples, % all represent mass unless otherwise specified.

[0044] [Examples, Comparative Examples] Liquid oral compositions (mouthwashes) with the compositions shown in Tables 1-6 were prepared by conventional methods and evaluated using the following methods. The results are shown in the table. Furthermore, the liquid oral composition (mouthwash) of the example had the medicinal effect of component (A) (bactericidal effect or effect of inhibiting stain adhesion to teeth).

[0045] Evaluation method Ten test subjects each took 10 mL of the liquid oral composition into their mouths, allowed it to swirl around for approximately 20 seconds, and then spat it out. After 5 minutes, they evaluated the absence of bitterness or irritation in the mouth (absence of bitterness / irritation after use), the absence of stickiness in the mouth after 5 minutes (absence of stickiness after use), and the quality of flavor development in the mouth during and after use (quality of flavor development during and after use) according to the following evaluation criteria. The average score of the 10 subjects was calculated and judged according to the following criteria. In this context, "stickiness" refers to the sticky, sweet feeling that lingers in the mouth after use.

[0046] No bitterness or irritation after use. Evaluation Criteria 4 points: No bitterness or irritation is felt in the mouth. 3 points: I don't feel much bitterness or irritation in my mouth. Points 2: A slight bitterness and irritation are felt in the mouth. 1 point: A bitter or irritating taste is felt in the mouth. Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score of 3.0 or higher but less than 3.5 points △: Average score between 2.0 and 3.0 ×: Average score less than 2.0 points

[0047] No stickiness after use Evaluation Criteria 4 points: No stickiness after use. 3 points: I don't feel much stickiness after use. 2 points: I feel a slight stickiness after use. 1 point: I feel a sticky residue after use. Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score of 3.0 or higher but less than 3.5 points △: Average score between 2.0 and 3.0 ×: Average score less than 2.0 points

[0048] Excellent flavor development during and after use. Evaluation Criteria 4 points: The flavor and aroma are very well expressed. 3 points: The aroma and flavor are well expressed. 2 points: The flavor is slightly better than average. 1 point: The flavor expression is poor (inhibited). Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score of 3.0 or higher but less than 3.5 points △: Average score between 2.0 and 3.0 ×: Average score less than 2.0 points

[0049] Details of components (D) and (E) used in each example are shown below. (D) Component Caryophyllene: Caryophyllene-BE (manufactured by Inoue Fragrance Manufacturing Co., Ltd.) Germacrene: Germacrene D (manufactured by Toronto Research) Viridiflorol: Viridiflorol (manufactured by Toronto Research) (E) Component Menthol: L-menthol (manufactured by Takasago International Corporation)

[0050] [Table 1]

[0051] [Table 2]

[0052] [Table 3]

[0053] [Table 4]

[0054] [Table 5]

[0055] [Table 6]

[0056] *The composition of the fragrances is shown in Table 7 (the same applies below). [Table 7]

[0057] Furthermore, oral compositions (toothpastes) with the compositions shown in Tables 8 and 9 were prepared by conventional methods, filled into tube containers, and evaluated in the same manner as described above. The results are also shown in the table. The evaluation method was the same as described above, except that 10 subject monitors squeezed out the oral composition (toothpaste) from a tube container, placed 1 cm on a toothbrush, brushed their teeth in the usual way for 3 minutes, rinsed their mouths, and were evaluated after 5 minutes. Furthermore, the details of the components (D) and (E) used are the same as described above. The oral composition (toothpaste) of the example had the medicinal effect of component (A) (bactericidal effect or effect of inhibiting stain adhesion to teeth).

[0058] [Table 8]

[0059] [Table 9]

Claims

1. (A) One or more selected from cationic disinfectants and condensed phosphates, (B) Sucralose, (C) One or more selected from (C-1) and (C-2) below (C-1) γ-decalactone, γ-undecalactone, and δ-dodecalactone (C-2) Vanillin, ethyl vanillin, maltol and ethyl maltol and (D) Two or more selected from caryophyllene, germacrene, and viridiflorol A liquid oral composition containing, (A) If the composition contains a cationic disinfectant, the amount is 0.005 to 0.1% by mass of the total composition, and if it contains a condensed phosphate, the amount is 0.1 to 3% by mass of the total composition. (B) The amount of component is 0.005 to 0.1% by mass of the total composition. The amount of component (C) is 0.001 to 0.056% by mass of the total composition. If (C-1) is present, the amount is 0.001 to 0.05% by mass of the total composition. If (C-2) is present, the amount is 0.00005 to 0.006% by mass of the total composition. A liquid oral composition in which the amount of component (D) is 0.000018 to 0.05 of the total composition.

2. The liquid oral composition according to claim 1, wherein component (A) is selected from cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine, pyrophosphate, tripolyphosphate, and hexametaphosphate.

3. The liquid oral composition according to claim 1 or 2, comprising components (C-1) and (C-2).

4. The liquid oral composition according to any one of claims 1 to 3, wherein component (C-2) is selected from vanillin and ethyl vanillin.

5. The liquid oral composition according to any one of claims 1 to 4, wherein component (D) is caryophyllene, germacrene, and viridiflorol, and the mass ratio of caryophyllene:germacrene:viridiflorol is 1:(1-2.5):(2-5).

6. Furthermore, the liquid oral composition according to any one of claims 1 to 5, wherein (E) it does not contain one or more selected from menthol and carvone, or it contains such that the amount is 0.05% by mass or less in the case of a mouthwash, and 0.5% by mass or less in the case of a toothpaste.

7. The liquid oral composition according to claim 6, which is a mouthwash and contains (E) one or more selected from menthol and carvone in an amount of 0.02% by mass or less.

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