Oral components

Abstract

To provide an oral composition having excellent stability (storage stability) of vitamin B5 or a derivative thereof, having pharmaceutical stability, and giving a high feeling of retention in the oral cavity.SOLUTION: The oral composition comprises (A) vitamin B5 or a derivative thereof, (B) a nonionic surfactant, and (C) a hydrocarbon oil in liquid state at 25°C. The content of the component (C) is 0.1 to. 9 mass%.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to an oral composition having excellent stability of vitamin B5 or its derivative.

Background Art

[0002] Vitamin B5 or its derivative, such as panthenol, is known to activate cells, promote the proliferation of fibroblasts, enhance metabolism, and suppress inflammation of the skin and the like. Further, it is used in cosmetics, shampoos, etc. for the purpose of preventing itching, caring for sunburned skin, and caring for the scalp as a moisturizer and a scalp protectant. Vitamin B5 or its derivative can be used for the purpose of improving metabolism and anti-inflammation in oral tissues by being formulated in an oral composition; however, it generally has poor stability in a dissolved state in water, and its effect decreases with time when formulated in an aqueous preparation. In particular, there has been a problem that it is difficult to formulate it as an active ingredient in an aqueous oral composition.

[0003] As past attempts to stabilize panthenol in an aqueous solution, a method of using boric acid in combination (Patent Document 1; JP-A-05-017355), a method of using boric acid and a compound having three or more hydroxyl groups in one molecule in combination (Patent Document 2; JP-A-2002-265357), a method of using allantoin and diphenhydramine in combination (Patent Document 3; JP-A-2006-335676), and a method of using ibuprofen piconol in combination (Patent Document 4; JP-A-2015-010060) have been proposed. However, since any of these methods uses pharmaceutical ingredients or the like that cannot be used for oral applications, they cannot be applied to oral compositions. On the other hand, methods have been proposed to improve the stability of water-based oral compositions by incorporating panthenol, using glycyrrhizinate salt, cetylpyridinium chloride, or a combination of both (Patent Documents 5-7; Japanese Patent Publication No. 2016-175875, Japanese Patent Publication No. 2016-179967, and Japanese Patent Publication No. 2016-185915), and various compositional examples for toothpaste and other forms are described. However, these technologies sometimes have limitations on composition, such as a limited range of active ingredients that can be incorporated, and the development of new technologies for stably incorporating vitamin B5 or its derivatives into oral compositions has been a challenge. [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 05-017355 [Patent Document 2] Japanese Patent Publication No. 2002-265357 [Patent Document 3] Japanese Patent Publication No. 2006-335676 [Patent Document 4] Japanese Patent Publication No. 2015-010060 [Patent Document 5] Japanese Patent Publication No. 2016-175875 [Patent Document 6] Japanese Patent Publication No. 2016-179967 [Patent Document 7] Japanese Patent Publication No. 2016-185915 [Patent Document 8] Japanese Patent Publication No. 2007-8831 [Overview of the project] [Problems that the invention aims to solve]

[0005] This invention has been made in view of the above circumstances, and aims to provide an oral composition that has excellent stability of vitamin B5 or its derivatives, as well as formulation stability. [Means for solving the problem]

[0006] As a result of diligent research to achieve the above objectives, the present inventors have discovered that when a nonionic surfactant and a specific amount of specific hydrocarbon oil are combined in an oral composition containing vitamin B5 or its derivatives, the stability of vitamin B5 or its derivatives is significantly improved, resulting in stable formulation over time, excellent storage stability, stable appearance of the formulation, and formulation stability. Furthermore, it is possible to provide a high level of oral retention sensation, leading to the present invention.

[0007] In other words, the present invention provides an oral composition containing (A) vitamin B5 or a derivative thereof, (B) a nonionic surfactant, and (C) a hydrocarbon oil that is liquid at 25°C, wherein the content of component (C) is within a specific range. This provides an oral composition with excellent stability (storage stability) of component (A), good formulation stability, and a high level of oral retention. To elaborate further, when component (A) is incorporated into an aqueous oral composition, such as a toothpaste composition, even when component (B), a known solubilizer, is added, component (A) decomposes over time, gradually decreasing in content, and the perceived retention of the formulation in the oral cavity is also low. On the other hand, when component (C) is added to a toothpaste composition containing component (A), the greater the amount added, the more liquid separation occurs over time, resulting in a significant deterioration of the formulation's appearance. However, according to the present invention, when the content of component (C) is within a specific range, components (B) and (C) form a stable emulsified form. As a result, even when component (A) is incorporated into an aqueous oral composition, formulation stability is ensured without deterioration of the formulation's appearance due to liquid separation over time, etc., allowing component (A) to be stably incorporated over time, providing excellent storage stability, and also providing a high perceived retention in the oral cavity, particularly the oral mucosa, which gives the feeling that the formulation is covering the oral cavity and working effectively. Furthermore, in oral compositions, such as toothpaste compositions, water-insoluble powders such as anhydrous silicic acid, which are generally used as binders and abrasives, contribute to ensuring the stability of the composition. However, as the amount of these powders decreases, stability tends to decline. With the oral composition of the present invention, even with a relatively small amount of anhydrous silicic acid, which is a water-insoluble powder, and even without the inclusion of abrasives, excellent stability (storage stability) of component (A) and formulation stability can be obtained. Patent Document 8 (Japanese Patent Publication No. 2007-8831) describes the improvement of the therapeutic effect of stomatitis in topical preparations by using panthenol in combination with allantoin or its derivatives. The formulation described as an example contains panthenol, polyoxyethylene hydrogenated castor oil, sorbitan monostearate, and light liquid paraffin, with the amount of light liquid paraffin being 13 g (13% by mass) per 100 g of the total formulation. In contrast, the present invention relates to an oral composition, particularly a toothpaste composition, in which, by combining components (A), (B), and (C), the formulation stability is particularly good while ensuring the stability (storage stability) of component (A) when the content of component (C) is 9% by mass or less. Furthermore, it can also provide a high sensation of lingering in the oral cavity after rinsing with water, exhibiting a particularly remarkable effect that cannot be obtained when the content of component (C) exceeds 9% by mass.

[0008] Accordingly, the present invention provides the following oral compositions. [1] (A) Vitamin B5 or its derivatives, (B) Nonionic surfactants and (C) Liquid hydrocarbon oil at 25℃ An oral composition characterized by containing (C) and having a content of 0.1 to 9% by mass. [2] The oral composition according to [1], wherein the content of component (A) is 0.1 to 5% by mass, and the content of component (B) is 0.5 to 10% by mass. [3] Furthermore, the oral composition according to [1] or [2] contains (D) a higher alcohol that is solid at 25°C. [4] The oral composition described in [3] in which the content of component (D) is 0.5 to 10% by mass. [5] The oral composition described in [3] or [4] in which (C) / (D) is 0.1 to 10 as a mass ratio. [6] The oral composition described in any one of [3] to [5] in which ((C)+(D)) / (B) is 0.5 to 8 as a mass ratio. [7] Furthermore, the oral composition described in any one of [1] to [6] containing (E) silicic anhydride. [8] The oral composition described in [7] in which the content of component (E) is 1 to 10% by mass. [9] The oral composition described in any one of [1] to [8] which is a dentifrice composition. [Advantages of the Invention]

[0009] According to the present invention, there is provided an oral composition which is excellent in the stability (storage stability) of (A) vitamin B5 or its derivative, has formulation stability, and gives a high feeling of retention in the oral cavity. The oral composition of the present invention can also stably and effectively exhibit the action effects such as improvement of metabolism of oral tissues and anti-inflammation by component (A), and is effective for prevention or suppression of periodontal diseases such as gingivitis. [Embodiments for Carrying Out the Invention]

[0010] [[ID=3?]]Hereinafter, the present invention will be described in more detail. The oral composition of the present invention contains (A) vitamin B5 or its derivative, (B) a nonionic surfactant, and (C) a hydrocarbon oil that is liquid at 25°C.

[0011] (A) Vitamin B5 or its derivative has a tissue repair action by cell activation, and is an active ingredient for improving metabolism of oral tissues and anti-inflammation. Examples of vitamin B5 or its derivatives include pantothenic acid, salts such as alkali metal salts of pantothenic acid, and panthenol which is an alcohol analog of pantothenic acid. Among them, panthenol is preferable from the viewpoint of tissue repair.

[0012] (A) The blending amount of vitamin B5 or its derivative is preferably 0.1 to 5% (mass%, the same hereinafter) of the whole composition, more preferably 0.2 to 1.0%, and still more preferably 0.3 to 0.5%. When the blending amount is within the above range, the effect of component (A) can be sufficiently obtained, and the stability of component (A) (storage stability, hereinafter abbreviated as "the stability of component (A)") and the formulation stability are improved, and a feeling of retention in the oral cavity of the formulation can be obtained.

[0013] In the present invention, by using (B) a nonionic surfactant and (C) a hydrocarbon oil that is liquid at 25°C in combination, this combined system forms a stable emulsion form, so that it is stably emulsified together with component (A), and excellent stability of component (A) and formulation stability can be obtained. If component (B) is not contained, formulation uniformity cannot be obtained, and if component (C) is not contained, the stability of component (A) is poor.

[0014] (B) The nonionic surfactant has an effect of suppressing the occurrence of liquid separation and the like caused by component (C) over time to improve the formulation stability, and also improving the stability of component (A) over time. (B) Examples of nonionic surfactants include polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers, sucrose fatty acid esters, alkyl glycosides, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene ethers of glycerin esters, fatty acid alkylolamides, glycerin fatty acid esters, etc., which may be used individually or in combination of two or more. Among these, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, and polyoxyethylene hydrogenated castor oil are preferred, and polyoxyethylene sorbitan fatty acid esters and sorbitan fatty acid esters are more preferred. It is most preferable to use polyoxyethylene sorbitan fatty acid esters and sorbitan fatty acid esters in combination. Furthermore, in terms of the stability of component (A) and formulation stability, polyoxyethylene sorbitan fatty acid esters are preferably those with 12 to 20 carbon atoms in the fatty acid and an average number of moles of ethylene oxide added of 10 to 30. Specifically, polyoxyethylene (20) sorbitan monostearate is an example. Sorbitan fatty acid esters are preferably those with 12 to 20 carbon atoms in the fatty acid, and specifically, sorbitan monostearate is an example. Polyoxyethylene hydrogenated castor oil is preferably those with an average number of moles of ethylene oxide added of 20 to 100.

[0015] (B) The amount of nonionic surfactant is preferably 0.5 to 10% of the total composition, more preferably 1 to 5%, and even more preferably 2 to 4%. If the amount is 0.5% or more, sufficient stability of component (A) and formulation stability are obtained, and if it is 10% or less, sufficient formulation stability is ensured, and the feeling of the formulation remaining in the oral cavity is also ensured.

[0016] (C) The hydrocarbon oil, which is liquid at 25°C, when used in combination with component (B), improves the stability of component (A) over time and also enhances the feeling of the formulation remaining in the oral cavity. Examples of hydrocarbon oils that are liquid at 25°C include liquid paraffin, light liquid paraffin, and squalane, which may be used individually or in combination of two or more. Among these, liquid paraffin (viscosity 37 mm) is particularly noteworthy. 2 / s or higher (37.8℃, 17th edition of the Japanese Pharmacopoeia), light liquid paraffin (viscosity 37mm 2 A temperature of less than 1 / s (37.8℃, 17th edition of the Japanese Pharmacopoeia) is preferred, and light liquid paraffin is more preferred in terms of formulation stability. Such liquid hydrocarbon oils at 25°C can be commercially available products such as liquid paraffin (Liquid paraffin No. 350S manufactured by Sanko Chemical Industry Co., Ltd.), light liquid paraffin (No. 70-S manufactured by Sanko Chemical Industry Co., Ltd.), or light liquid paraffin (Highcol M72 manufactured by Kaneda Co., Ltd.).

[0017] (C) The amount of hydrocarbon oil that is liquid at 25°C is 0.1 to 9% of the total composition, preferably 1 to 9%, and more preferably 2 to 6%. If the amount is less than 0.1%, the stability of component (A) is poor, and the oral retention sensation of the formulation is also poor. As the amount increases, the formulation stability decreases, and if it exceeds 9%, the formulation stability deteriorates.

[0018] The oral composition of the present invention preferably further contains (D) a higher alcohol that is solid at 25°C. The inclusion of component (D) further improves the stability of the formulation, and further improves the stability of component (A), and also enhances the feeling of the formulation remaining in the oral cavity. Examples of higher alcohols that are solid at 25°C include higher alcohols with 16 to 22 carbon atoms, such as stearyl alcohol, cetanol, cetostearyl alcohol, and behenyl alcohol. These can be used individually or in combination of two or more. Among these, higher alcohols with 16 to 18 carbon atoms, such as stearyl alcohol, cetanol, and cetostearyl alcohol, are preferred, with cetanol being more preferred. Specifically, for example, cetanol (melting point 47-53°C) listed in the Japanese Pharmacopoeia is commercially available and can be used.

[0019] (D) When a higher alcohol that is solid at 25°C is included, the amount included is preferably 0.5 to 10% of the total composition, more preferably 1 to 8%, and even more preferably 3 to 6%, in terms of improving the stability of the formulation and the stability of component (A), and improving the feeling of the formulation remaining in the oral cavity.

[0020] Furthermore, the (C) / (D) ratio, which indicates the amount ratio of component (C) to component (D), is preferably 0.1 to 10, more preferably 0.5 to 8, and even more preferably 1 to 4 as a mass ratio. Within this range, formulation stability and the feeling of the formulation remaining in the oral cavity are further improved. Furthermore, the ratio ((C)+(D)) / (B), which represents the ratio of the total amount of components (C) and (D) to the amount of component (B), is preferably 0.5 to 8, more preferably 0.5 to 5, and even more preferably 0.7 to 4 as a mass ratio. Within this range, the formulation stability and the perceived retention of the formulation in the oral cavity are even more remarkably superior.

[0021] In terms of formulation stability, it is preferable to further incorporate (E) anhydrous silicic acid into the oral composition of the present invention. (E) Examples of inorganic silicic acid include thickening anhydrous silicic acid such as thickening silica and thickening aluminum silica, and abrasive anhydrous silicic acid such as precipitated silica, aluminosilicate and zirconosilicate. In particular, it is preferable to use thickening anhydrous silicic acid, and thickening silica with an absorption capacity (45% glycerin aqueous solution) of 1.5 to 6 ml / g, and especially 2 to 5 ml / g, can be used. (E) Specifically, commercially available anhydrous silicic acid such as Carplex #67Q (thickening silica with a liquid absorption capacity of 2.3 ml / g) from DSL Japan Co., Ltd., AEROSIL 200 (thickening silica with a liquid absorption capacity of 4.3 ml / g) from Nippon Aerosil Co., Ltd., and Silysia 320 (thickening silica with a liquid absorption capacity of 3.0 ml / g) from Fuji Silysia Chemical Co., Ltd. can be used.

[0022] (E) When anhydrous silicic acid is included, the amount is preferably 1 to 10% of the total composition, more preferably 2 to 7%, and even more preferably 3 to 5%.

[0023] The oral compositions of the present invention are particularly suitable as toothpaste compositions such as toothpaste and gel toothpaste. In addition to the above components, other known components may be added as needed, within a range that does not hinder the effects of the present invention. For example, in toothpaste, abrasives, viscosity agents, binders, surfactants, and optionally colorants, sweeteners, preservatives, fragrances, and active ingredients may be added. Gel toothpaste usually does not contain abrasives, but other possible components are the same as those for toothpaste. The amounts shown below are relative to the total composition.

[0024] Examples of abrasives include calcium phosphate compounds such as silicon dioxide, discalcium phosphate dihydrate or anhydrous, calcium carbonate, and synthetic resin-based abrasives. The amount of abrasive added can be 0-50%, 2-50%, or especially 2-30%. Furthermore, the oral composition of the present invention may be free of abrasives, and even without abrasives, the stability of component (A) and formulation stability are excellent.

[0025] Examples of viscosity-enhancing agents include sugar alcohols such as sorbitol and xylitol, and polyhydric alcohols such as glycerin and propylene glycol. The amount of viscosity-enhancing agent added is typically 5-50%, and especially 10-30%.

[0026] Organic binders can be incorporated as binders. Examples include cellulose derivatives such as hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium carboxymethylcellulose, and methylcellulose, alginic acid derivatives, gums such as xanthan gum, sodium polyacrylate, and carboxyvinyl polymer. Cellulose derivatives are particularly preferred in terms of formulation stability. The amount of these binders incorporated is usually 0.1 to 10%, and especially 0.1 to 5%.

[0027] Any surfactant other than (B) nonionic surfactants may be used, and anionic surfactants, cationic surfactants, and amphoteric surfactants may be included. Examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, acyl sarcosinates, acyl taurines, and acyl amino acids. Examples of cationic surfactants include alkylammonium types and quaternary ammonium salts such as alkylbenzylammonium salts. Examples of amphoteric surfactants include alkyl betaines, fatty acid amidopropyl betaines such as coconut oil fatty acid amidopropyl betaine, alkylimidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine. The amount of these optional surfactants blended is preferably 0 to 10%, and if blended, it can be 0.001 to 10%, and especially 0.001 to 5%.

[0028] Examples of colorants include Blue No. 1, Yellow No. 4, and titanium dioxide. Examples of sweeteners include sodium saccharin. Examples of preservatives include parahydroxybenzoic acid esters such as methylparaben (methyl parahydroxybenzoate), benzoic acid, or salts thereof.

[0029] The fragrances include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, and sweetie oil. - Natural fragrances such as oil, yuzu oil, iris concrete, absolute peppermint, absolute rose, orange blossom, etc., as well as fragrances obtained by processing these natural fragrances (pre-distillation cutting, post-distillation cutting, fractional distillation, liquid-liquid extraction, essence production, powder fragrance production, etc.), and furthermore, menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, thymol, linalool, linaleal acetate Individual fragrances such as limonene, menthone, menthyl acetate, N-ethyl-paramenthane-3-carboxamide, pinene, octylaldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allylcyclohexanepropionate, methyl anthranilate, ethyl methylphenyl glycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, and ethyl thioacetate, as well as combinations of known fragrance materials used in oral compositions such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor, can be used. The amount of fragrance to be blended is not particularly limited, but the amount of the above-mentioned fragrance material is preferably 0.000001 to 1%. The amount of fragrance used for fragrance application using the above-mentioned fragrance material is preferably 0.1 to 2%, and more preferably 0.2 to 1%.

[0030] Any active ingredient that is acceptable for oral formulations can be used, and examples include, but are not limited to, nonionic disinfectants such as isopropylmethylphenol, cationic disinfectants such as cetylpyridinium chloride, anti-inflammatory agents such as tranexamic acid, allantoin, and glycyrrhetinic acid, enzymes such as dextranase, fluorine-containing compounds such as sodium fluoride, tin fluoride, and sodium monofluorophosphate, water-soluble phosphate compounds, inorganic salts such as sodium chloride, potassium nitrate, and aluminum lactate, ascorbic acid, tocopherol acetate, plant extracts, calculus inhibitors, and plaque inhibitors. These active ingredients can be incorporated in effective amounts as long as they do not interfere with the effects of the present invention. [Examples]

[0031] The present invention will be specifically described below with reference to examples, comparative examples, and formulation examples, but the present invention is not limited to the following examples. In the following examples, % all refer to mass % unless otherwise specified.

[0032] [Examples, Comparative Examples] Toothpaste compositions (toothpaste) with the compositions shown in Tables 1-3 were prepared using the following preparation method and evaluated using the methods (1)-(3) below. The results are shown in the table. Method for preparing toothpaste composition: An oil layer containing a surfactant, an oil agent, and a hydrophobic component, and an aqueous layer containing water, a hydrophilic component, and an inorganic powder were each heated to 60°C, emulsified, cooled, and then fragrance was added to prepare a toothpaste composition.

[0033] (1) Method for evaluating the stability of the formulation 90g of toothpaste composition was filled into a standard aluminum laminate tube container and stored at 60°C for one month. After that, the toothpaste composition was squeezed out of the tube container, and its formulation stability (absence of liquid separation) was evaluated according to the following evaluation criteria. Evaluation Criteria ☆: No liquid separation at all. ◎: Liquid separation is barely noticeable, only slightly at the mouth of the tube container. ○: Some liquid separation is observed from the mouth of the tube container to the inside, but this is not a problem. ×: Significant liquid separation is observed.

[0034] (2) (A) Method for evaluating the stability of vitamin B5 or its derivatives 90g of toothpaste composition was filled into a standard aluminum laminate tube container and stored at 60°C for one month. The remaining amount of (A) vitamin B5 or its derivative was then measured by high-performance liquid chromatography. The ratio of the content of (A) component after one month of storage at 60°C to the content of (A) component immediately after preparation (theoretical value) of each toothpaste composition (remaining rate, %) was calculated using the following formula, and the stability of (A) component (storage stability) was evaluated according to the following evaluation criteria. Furthermore, for toothpaste compositions in which significant liquid separation was observed after storage at 60°C for one month ((1) Evaluation result of formulation stability ×), the residual amount of component (A) was not measured and the stability of component (A) was not evaluated due to the non-uniformity of the formulation. Panthenol retention rate (%) = {(Content of component (A) after storage at 60°C for 1 month) / (Content of component (A) immediately after preparation) (Theoretical value of content) × 100 Evaluation Criteria ☆: 98% or higher ◎: 95% or more and less than 98% ○: 90% or more but less than 95% ×: Less than 90%

[0035] (3) Method for evaluating the perceived retention of the formulation in the oral cavity Five expert panelists evaluated the perceived retention of the toothpaste composition in the oral cavity immediately after preparation. One g of toothpaste composition was placed on a toothbrush (Lion Corporation, Clinica Advantage toothbrush, 4-row compact, medium type), and teeth were brushed for three minutes using the usual method. After rinsing the mouth with water, the feeling of retention on the oral mucosa immediately after use was evaluated according to the following scoring criteria. Here, the sensation of the formulation remaining in the oral cavity refers to the feeling that the oral mucosa is covered with the formulation. Rating Criteria 1: I don't feel any sense of stagnation. 2: I hardly feel any sense of being stuck. 3: I feel a slight sense of stagnation. 4: I feel a strong sense of being stuck in a rut. 5: I feel a strong sense of being stuck in a rut. The average score from the five participants was calculated, and the perceived retention of the formulation was evaluated using the following evaluation criteria. Evaluation criteria (a score of ○ or higher was considered a passing grade) ☆: The average score of the 5 people is 4.5 or higher. ◎: The average score of the 5 people is between 4 and 4.5 points. ○: The average score of the 5 people is between 3 and 4 points. ×: The average score of the five people is less than 3 points.

[0036] Details of the raw materials used are shown below. POE is an abbreviation for polyoxyethylene, and the number in parentheses after POE represents the average number of moles of ethylene oxide added. (A) Panthenol; manufactured by DSM Co., Ltd., Panthenol (B) POE(20) Sorbitan Monostearate; manufactured by Nippon Surfactant Industry Co., Ltd., TS-10MV (B) Sorbitan monostearate; manufactured by Nippon Surfactant Industry Co., Ltd., SS-10MV (B) POE(60) Hydrogenated Castor Oil; manufactured by Nikko Chemicals Co., Ltd., HCO-60 Coconut oil fatty acid amidopropyl betaine (comparative product); manufactured by Degussa, TEGO BETAIN CK-OK (C) Light liquid paraffin; manufactured by Sanko Chemical Industry Co., Ltd., Liquid paraffin No. 70-S (C) Liquid paraffin; manufactured by Sanko Chemical Industry Co., Ltd., Liquid paraffin No. 350S Vaseline (comparative product); manufactured by Nikko Rica Co., Ltd., Sunwhite P-1 (D) Cetanol; manufactured by Kao Corporation, Nichikyoku Cetanol, "Japanese Pharmacopoeia Cetanol" (melting point 47-53°C) (D) Stearyl alcohol; manufactured by Higher Alcohol Industry Co., Ltd., Stearyl Alcohol NX (E) Anhydrous silicic acid; manufactured by Nippon Aerosil Co., Ltd., AEROSIL 200 Hydroxyethylcellulose 1; manufactured by Daicel Mirise Co., Ltd., HEC Daicel EE820 Hydroxyethylcellulose 2; manufactured by Ashland Industries Netherlands BV, Natrosol 250 HX Pharm Hydroxypropyl methylcellulose; manufactured by Shin-Etsu Chemical Co., Ltd., METOLOSE 90SH-4000SR

[0037] [Table 1] *; Due to the heterogeneity of the formulation, the stability of component (A) was not evaluated.

[0038] [Table 2]

[0039] [Table 3]

[0040] Next, we present an example of a formulation. When the toothpaste of the example formulation was prepared in the same manner using the same raw materials as in the above example and evaluated, it was found that (A) the stability (storage stability) and formulation stability of the component were excellent, and the feeling of the formulation remaining in the oral cavity was also good. (B) Sucrose fatty acid ester was manufactured by Mitsubishi Chemical Foods Corporation, Surfhope SE PHARMA J-1816, and (B) POE(20) sorbitan monostearate was manufactured by Nippon Surfactant Industry Co., Ltd., TS-10MV.

[0041] [Prescription Example 1] Toothpaste (A) Panthenol 0.4 Glycyrrhetinic acid 0.4 Tocopherol acetate 2.0 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 1.5 (B) Sorbitan monostearate 1.0 (C) Light liquid paraffin 4 (D) Cetanol 3 (E) Anhydrous silicic acid 3.0 Hydroxyethylcellulose 1 2.0 Sorbitol solution (70%) 30 Methyl parahydroxybenzoate 0.1 Ethanol 2.0 Sodium lauryl sulfate 2.0 Sodium saccharin hydrate 0.1 Fragrance 1.5 Refined water residue Total 100% Mass ratio of (C) / (D): 1.3 The mass ratio of ((C)+(D)) / (B) is 1.6.

[0042] [Prescription Example 2] Toothpaste (A) Panthenol 0.4 Glycyrrhetinic acid 0.4 Cetylpyridinium chloride hydrate 0.05 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 2.5 (B) Sorbitan monostearate 0.5 (C) Light liquid paraffin 5 (D) Cetanol 5 (E) Anhydrous silicic acid 5.0 Hydroxyethylcellulose 1 1.0 Hydroxypropyl methylcellulose 1.5 Sorbitol solution (70%) 10 Propylene glycol 5 Ethyl parahydroxybenzoate 0.1 Sodium lauryl sulfate 1.0 Sodium saccharin hydrate 0.2 Fragrance 1.5 Refined water residue Total 100% (C) / (D) mass ratio; 1 The mass ratio of ((C)+(D)) / (B) is 2.0.

[0043] [Prescription Example 3] Toothpaste (A) Panthenol 0.3 Glycyrrhetinic acid 0.3 Tocopherol acetate 2.0 Cetylpyridinium chloride hydrate 0.05 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 1.5 (B) Sorbitan monostearate 1.0 (C) Light liquid paraffin 2.0 (D) Cetanol 1.4 (E) Anhydrous silicic acid 3.0 Hydroxyethylcellulose 2 1.5 Hydroxypropyl methylcellulose 0.5 Sorbitol solution (70%) 20 Propylene glycol 5 Methyl parahydroxybenzoate 0.1 Ethyl parahydroxybenzoate 0.1 Sodium lauryl sulfate 1.6 Sodium saccharin hydrate 0.2 Ethanol 1.0 Fragrance 1.5 Refined water residue Total 100% Mass ratio of (C) / (D): 1.4 The mass ratio of ((C)+(D)) / (B) is 0.8.

[0044] [Prescription Example 4] Toothpaste (A) Panthenol 0.3 Glycyrrhetinic acid 0.3 Tocopherol acetate 2.0 Cetylpyridinium chloride hydrate 0.05 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 1.5 (B) Sorbitan monostearate 1.0 (C) Light liquid paraffin 2.0 (D) Cetanol 1.4 (E) Anhydrous silicic acid 3.0 Hydroxyethylcellulose 2 1.5 Hydroxypropyl methylcellulose 1.0 Sorbitol solution (70%) 20 Propylene glycol 5 Methyl parahydroxybenzoate 0.1 Ethyl parahydroxybenzoate 0.1 Sodium lauryl sulfate 0.8 Sodium saccharin hydrate 0.2 Ethanol 1.0 Fragrance 1.5 Refined water residue Total 100% Mass ratio of (C) / (D): 1.4 The mass ratio of ((C)+(D)) / (B) is 0.8.

[0045] [Prescription Example 5] Toothpaste (A) Panthenol 0.3 Glycyrrhetinic acid 0.3 Tocopherol acetate 2.0 Cetylpyridinium chloride hydrate 0.05 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 1.5 (B) Sorbitan monostearate 1.0 (C) Light liquid paraffin 4.0 (D) Cetanol 1.4 (E) Anhydrous silicic acid 3.0 Hydroxyethylcellulose 2 1.5 Hydroxypropyl methylcellulose 0.5 Sorbitol solution (70%) 20 Propylene glycol 5 Methyl parahydroxybenzoate 0.1 Ethyl parahydroxybenzoate 0.1 Sodium lauryl sulfate 1.6 Sodium saccharin hydrate 0.2 Ethanol 1.0 Fragrance 1.5 Refined water residue Total 100% Mass ratio of (C) / (D): 1.4 The mass ratio of ((C)+(D)) / (B): 1.2

[0046] [Prescription Example 6] Toothpaste (A) Panthenol 0.3 Glycyrrhetinic acid 0.3 Tocopherol acetate 2.0 Cetylpyridinium chloride hydrate 0.05 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 1.5 (B) Sorbitan monostearate 1.0 (C) Light liquid paraffin 2.0 (D) Cetanol 1.4 (E) Anhydrous silicic acid 3.0 Hydroxyethylcellulose 1 1.5 Hydroxypropyl methylcellulose 1.0 Sorbitol solution (70%) 20 Propylene glycol 5 Methyl parahydroxybenzoate 0.1 Ethyl parahydroxybenzoate 0.1 Sodium lauryl sulfate 1.6 Sodium saccharin hydrate 0.15 Ethanol 1.0 Fragrance 1.5 Refined water residue Total 100% Mass ratio of (C) / (D): 1.4 The mass ratio of ((C)+(D)) / (B) is 0.8.

[0047] [Prescription Example 7] Toothpaste (A) Panthenol 0.3 Glycyrrhetinic acid 0.3 Tocopherol acetate 2.0 Cetylpyridinium chloride hydrate 0.05 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 1.5 (B) Sorbitan monostearate 1.0 (C) Light liquid paraffin 4.0 (D) Cetanol 1.4 (E) Anhydrous silicic acid 3.0 Hydroxyethylcellulose 2 1.5 Hydroxypropyl methylcellulose 1.0 Sorbitol solution (70%) 20 Propylene glycol 5 Methyl parahydroxybenzoate 0.1 Ethyl parahydroxybenzoate 0.1 Sodium lauryl sulfate 1.6 Sodium saccharin hydrate 0.2 Ethanol 1.0 Fragrance 1.5 Refined water residue Total 100% Mass ratio of (C) / (D): 1.4 The mass ratio of ((C)+(D)) / (B): 1.2

[0048] [Prescription Example 8] Toothpaste (A) Panthenol 0.3 Glycyrrhetinic acid 0.3 Tocopherol acetate 2.0 Cetylpyridinium chloride hydrate 0.05 (B) Sucrose fatty acid ester 2.0 (B)POE(20) Sorbitan Monostearate 1.5 (B) Sorbitan monostearate 1.0 (C) Light liquid paraffin 2.0 (D) Cetanol 1.4 (E) Anhydrous silicic acid 3.0 Hydroxyethylcellulose 2 2.0 Hydroxypropyl methylcellulose 0.5 Sorbitol solution (70%) 20 Propylene glycol 5 Methyl parahydroxybenzoate 0.1 Ethyl parahydroxybenzoate 0.1 Sodium lauryl sulfate 1.6 Sodium saccharin hydrate 0.2 Ethanol 1.0 Fragrance 1.5 Refined water residue Total 100% Mass ratio of (C) / (D): 1.4 The mass ratio of ((C)+(D)) / (B): 1.2

Claims

1. (A) Vitamin B5 or its derivatives, (B) A nonionic surfactant selected from polyoxyethylene sorbitan fatty acid esters having 12 to 20 carbon atoms in the fatty acid and an average number of added moles of ethylene oxide of 10 to 30, sorbitan fatty acid esters having 12 to 20 carbon atoms in the fatty acid, polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide of 20 to 100, and sucrose fatty acid esters, and (C) Light liquid paraffins and hydrocarbon oils selected from liquid paraffins that are liquid at 25°C It contains, (A) The content of component is 0.1 to 5% by mass, (B) The content of component is 0.5 to 10% by mass. An oral composition characterized by having a content of component (C) of 0.1 to 9% by mass.

2. Furthermore, the oral composition according to claim 1, further comprising (D) a higher alcohol that is solid at 25°C.

3. The oral composition according to claim 2, wherein the content of component (D) is 0.5 to 10% by mass.

4. The oral composition according to claim 2 or 3, wherein (C) / (D) is 0.1 to 10 as a mass ratio.

5. An oral composition according to any one of claims 2 to 4, wherein ((C) + (D)) / (B) is 0.5 to 8 in mass ratio.

6. Furthermore, the oral composition according to any one of claims 1 to 5, further comprising (E) anhydrous silicic acid.

7. The oral composition according to claim 6, wherein the content of component (E) is 1 to 10% by mass.

8. An oral composition according to any one of claims 1 to 7, which is a toothpaste composition.

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