Oily components

Abstract

To provide a novel oil-based composition.SOLUTION: An oil-based composition comprises (A) mucopolysaccharide, (B) liquid oil, (C) nonionic surfactant, and (D) at least one selected from (D1) phospholipid and (D2) sterol.SELECTED DRAWING: None

Description

Technical Field

[0001] The present invention relates to a novel composition (an oily composition).

Background Art

[0002] Mucopolysaccharides such as heparin analogs are known to have functions such as a moisturizing function, and external preparations utilizing the functions of such mucopolysaccharides are being developed.

[0003] For example, Patent Document 1 (Japanese Patent Application Laid-Open No. 2009-234957) discloses an external preparation for skin containing ceramide and a heparin analog.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] An object of the present invention is to provide a novel composition (an oily composition).

Means for Solving the Problems

[0006] As described above, mucopolysaccharides such as heparin analogs are used as external preparations and the like by utilizing their moisturizing function, anti-inflammatory action, blood flow increasing action, and the like.

[0007] Mucopolysaccharides are generally hydrophilic, so to form an oily composition, it is conceivable to use solubilizing, emulsifying, or ointment compositions based on their solubility. However, according to the inventors' research, simply blending them with liquid oil sometimes results in cloudiness and / or precipitation / settling, making the mixture opaque and / or non-uniform, and causing a loss of transparency and / or uniformity in appearance (and consequently impairing the sense of luxury and stability as a formulation). Furthermore, possibly related to this opacity, there was a problem of unpleasantness such as stickiness due to the liquid oil remaining on the skin. Furthermore, the inventors' studies have shown that, in the case of solubilized emulsions, the film formed when applied to the skin alone is not sufficient to prevent evaporation of skin moisture, and depending on the composition, a sufficient moisturizing effect may not be obtained.

[0008] Furthermore, the inventors considered incorporating mucopolysaccharides into highly emollient liquid oils. However, even when mucopolysaccharides were incorporated into liquid oils, the resulting product was sometimes unsatisfactory in terms of usability, such as being poorly absorbed by the skin.

[0009] Under these circumstances, the inventors diligently conducted research to solve the above problems and found that a novel composition (oil-based composition) can be obtained by combining mucopolysaccharides with specific components, and that such a composition can improve transparency and other properties despite being an oil-based composition containing mucopolysaccharides. Further research led to the completion of the present invention.

[0010] In other words, the present invention relates to the following inventions, etc. [1] (A) Mucopolysaccharides, (B) Liquid oil, (C) Nonionic surfactants, and A liquid oily composition containing one or more selected from (D)(D1) phospholipids and (D2) sterols. [2] (A) The composition according to [1], which contains one or more mucopolysaccharides selected from hyaluronic acid, heparinoids, chondroitin sulfate, dextran sulfate, and salts thereof. [3] (B) The composition according to [1] or [2], wherein the liquid oil comprises (B1) a non-polar oil and (B2) a polar oil having an IOB value of 0.05 or higher. [4] (B) The composition according to any one of [1] to [3], wherein the liquid oil comprises a polar oil having an IOB value of 0.05 or higher, and the IOB value of the polar oil is 0.12 or higher (for example, 0.12 to 0.5). [5] (B) The composition according to any one of [1] to [4], wherein the liquid oil comprises (B1) a non-polar oil and (B2) a polar oil having an IOB value of 0.05 or more, and the amount of (B1) non-polar oil is 1.2 parts by mass or less per 1 part by mass of the polar oil having an IOB value of 0.05 or more. [6] (D1) A composition according to any one of [1] to [5], wherein the phospholipid contains lecithin. [7] (D2) A composition according to any one of [1] to [6], comprising at least one sterol selected from cholesterol and phytosterols. [8] A composition according to any one of [1] to [7], comprising (D1) phospholipids and (D2) sterols. [9] (A) Mucopolysaccharides, (B) Liquid oil, (C) Nonionic surfactants, and (D)(D1)A composition containing phospholipids and (D2) sterols, (B) A liquid oily composition comprising (B1) a non-polar oil and (B2) a polar oil having an IOB value of 0.05 or higher.

[10] (B) The liquid oil contains (B2) a polar oil with an IOB value of 0.05 or higher. (B2) A composition according to any one of [1] to [9], wherein the polar oil is a polar oil having an IOB value of 0.12 or higher.

[11] (A) Mucopolysaccharides, (B) Liquid oil, and (C) A method for improving at least one selected from transparency, uniformity, storage stability, moisturizing property, and usability of a liquid oily composition containing a nonionic surfactant, comprising (D) A method of incorporating into the composition one or more selected from (D1) phospholipids and (D2) sterols.

[12] (A) Polysaccharide (B) Liquid oil, and (C) A method for improving at least one selected from transparency, uniformity, storage stability, moisturizing property, and usability of a liquid oily composition containing a nonionic surfactant, comprising (D) Incorporating into the composition one or more selected from (D1) phospholipids and (D2) sterols, and (B) A method of making the liquid oil in at least one mode selected from the following (1) and (2). (1) Incorporate (B1) nonpolar oil and (B2) polar oil with an IOB value of 0.05 or more into (B) liquid oil. (2) Incorporate (B2) polar oil with an IOB value of 0.05 or more into (B) liquid oil, and make the IOB value of (B2) polar oil 0.12 or more (for example, 0.12 to 0.5).

[13] The method according to

[11] or

[12] , wherein the usability is at least one selected from skin affinity, softness of the skin, lack of glare, lack of stickiness, and feeling of penetration.

Advantages of the Invention

[0011] The present invention can provide a novel composition (oily composition) containing a polysaccharide (such as a heparin-like substance) and a liquid oil.

[0012] In another aspect of the composition of the present invention, the transparency and uniformity of the oily composition containing a polysaccharide can be improved. In particular, in another aspect of the present invention, a composition (oily composition) excellent in transparency and uniformity [or having low turbidity (turbidity), particularly clear] can be provided, although it contains a polysaccharide, a liquid oil, and (furthermore water).

[0013] In other embodiments of the composition of the present invention, the storage stability of an oily composition containing mucopolysaccharides can be improved (or enhanced) (for example, maintaining transparency or uniformity).

[0014] In other embodiments of the composition of the present invention, the transparency and uniformity of an oily composition containing mucopolysaccharides can be improved (or enhanced) even at low temperatures (e.g., 10°C or below, 8°C or below, 5°C or below, 4°C or below, etc.).

[0015] In other embodiments of the composition of the present invention, the moisturizing properties (water retention) of an oily composition containing mucopolysaccharides can be improved (or enhanced).

[0016] In other embodiments of the composition of the present invention, the feel of an oily composition containing mucopolysaccharides (for example, at least one selected from skin compatibility, penetration, non-stickiness, softness (skin softness), and non-greasy feel) can be improved (or enhanced).

[0017] In another aspect of the present invention, even when combining mucopolysaccharides with specific components, it is possible to provide an oily composition (oily composition) that is excellent in transparency and uniformity (especially clear) without using a large amount of surfactant (and even a large amount of highly polar liquid oil). Therefore, in such an aspect, adverse effects (e.g., skin irritation) caused by using a large amount of surfactant or highly polar liquid oil can be suppressed (reduced) or prevented.

[0018] Thus, the composition of the present invention is extremely useful and highly practical. [Modes for carrying out the invention]

[0019] [1. Composition] The composition of the present invention (oil-based composition, oil-based formulation) contains at least (A) mucopolysaccharides and (B) liquid oil. The oily composition may contain a predetermined amount of water (component (E)) (for example, 15% by mass or less, preferably 10% by mass or less, more preferably 7% by mass or less, even more preferably 5% by mass or less, particularly preferably 3% by mass or less, and most preferably 2% by mass or less), or may not contain water.

[0020] (A) Mucopolysaccharides (Component (A)) Examples of mucopolysaccharides include heparin-like substances, chondroitin sulfate, hyaluronic acid, dextran sulfate, alginic acid, and their salts.

[0021] Salts include pharmaceutically, pharmacologically, or physiologically acceptable salts. Examples of such salts include salts with organic acids [e.g., monocarboxylates (acetate, trifluoroacetate, butyrate, palmitate, stearate, etc.), polycarboxylic acids (fumarate, maleate, etc.), oxycarboxylates (lactate, tartrate, citrate, succinate, malonate, etc.), organic sulfonates (methanesulfonate, toluenesulfonate, tosylate, etc.)], salts with inorganic acids (e.g., hydrochloride, sulfate, nitrate, hydrobromide, phosphate, etc.), salts with organic bases (e.g., salts with organic amines such as methylamine, triethylamine, triethanolamine, morpholine, piperazine, pyrrolidine, tripyridine, picoline, etc.), and salts with inorganic bases [e.g., ammonium salts; salts with metals such as alkali metals (sodium, potassium, etc.), alkaline earth metals (calcium, magnesium, etc.), and aluminum, etc.], etc.], which are appropriately selected depending on the compound.

[0022] Specific examples of salts include chondroitin sulfate (e.g., sodium chondroitin sulfate), hyaluronic acid (e.g., sodium hyaluronate), and dextran sulfate (e.g., sodium dextran sulfate).

[0023] Mucopolysaccharides may also be glycosaminoglycans.

[0024] (A) Component may be used alone or in combination of two or more.

[0025] In particular, one or more selected from hyaluronic acid, heparinoid, chondroitin sulfate, dextran sulfate, and salts thereof (especially at least heparinoid) can be suitably used. Therefore, component (A) may contain one or more selected from hyaluronic acid, heparinoid, chondroitin sulfate, dextran sulfate, and salts thereof (especially at least heparinoid). Furthermore, while heparin-like substances and the like are components that are difficult to solubilize in oily compositions, according to the present invention, even such heparin-like substances can be efficiently solubilized.

[0026] Heparin-like substances are polysulfated mucopolysaccharides. In heparin-like substances, the number of sulfate groups per monosaccharide (molecule) constituting the mucopolysaccharide may be, for example, an average of 0.5 to 5 (for example, an average of 0.6 to 3).

[0027] Furthermore, heparin-like substances may be commercially available or prepared by conventional methods (for example, by sulfating mucopolysaccharides). In particular, since heparin-like substances are commercially available as raw materials for pharmaceuticals and cosmetics, commercially available products may be used. In particular, heparin-like substances included in the Japanese Pharmacopoeia Standards for Non-Official Drugs may be suitably used.

[0028] If component (A) contains a heparin-like substance, the proportion of the heparin-like substance to the total component (A) may be selected from a range of, for example, 10% by mass or more, and may be 30% by mass or more, preferably 50% by mass or more, and more preferably 70% by mass or more (for example, 80% by mass or more, 85% by mass or more, 90% by mass or more, 95% by mass or more, 99% by mass or more, 100% by mass, etc.).

[0029] The content of component (A) in the composition can be selected according to the type of component (A) and the intended use of the composition, but it may be selected from a range of, for example, 0.001% by mass or more (for example, 0.003% by mass or more, 0.005% by mass or more, 0.007% by mass or more) relative to the total amount of the composition, and may be 0.005 to 10% by mass (for example, 0.01 to 5% by mass), preferably 0.03 to 3% by mass, more preferably 0.05 to 1% by mass, and most preferably about 0.1 to 0.5% by mass.

[0030] (B) Liquid oil (Component (B)) Liquid oils can be broadly classified into non-polar oils (liquid non-polar oils) and polar oils (liquid polar oils). The boundary between non-polar oils and polar oils is not particularly limited, but for example, liquid oils with an IOB (Inorganic-Organic Balance) value of 0.05 or higher may be classified as "polar oils," and other liquid oils, i.e., liquid oils with an IOB value of less than 0.05 (0 or more and less than 0.05), may be classified as "non-polar oils."

[0031] Furthermore, the liquid oil only needs to be liquid when the composition is used, but it may also be an oil that is liquid at 25°C (equivalent to room temperature).

[0032] Liquid oils typically contain at least a polar oil, and more preferably both a polar oil and a non-polar oil. The inclusion of a polar oil allows for efficient achievement of the effects of the present invention (e.g., improved transparency and uniformity, enhanced moisturizing properties and usability). Furthermore, combining polar and non-polar oils offers advantages in terms of safety and cost.

[0033] The following provides a detailed explanation of liquid oils.

[0034] ·Non-polar oil ((B1) component) The non-polar oil [(B1) non-polar oil ((B1) component)] is not particularly limited, but examples include hydrocarbon oils such as liquid paraffin, liquid isoparaffin, squalane, squalene, and α-olefin oligomers.

[0035] Non-polar oils may be used alone or in combination of two or more types.

[0036] ·Polar oil ((B2) component) As mentioned above, polar oils [(B2) polar oils ((B2) components)] include oils (oil components) with an IOB value of a specific value or higher (for example, 0.05 or higher).

[0037] In polar oils, the upper limit of the IOB value is not particularly limited, but may be, for example, 0.8, 0.7, 0.65, 0.6, 0.58, 0.55, 0.54, 0.5, 0.48, 0.46, 0.45, 0.42, 0.4, 0.38, 0.35, 0.32, 0.3, etc.

[0038] When combining two or more polar oils, the IOB value of each polar oil may normally be 0.05 or higher.

[0039] Examples of such polar oils include fats and oils, ester oils [esters other than fats and oils (e.g., vegetable oils, animal oils, medium-chain triglyceride fatty acids)], silicone oils, fatty acids, and aliphatic alcohols (aliphatic monools, etc.).

[0040] Typical polar oils include fats and oils, ester oils, carboxylic acids (e.g., fatty acids such as isostearic acid and oleic acid (higher fatty acids, etc.)), and aliphatic alcohols (e.g., aliphatic higher alcohols such as lauryl alcohol and octyldodecanol).

[0041] Examples of fats and oils include vegetable oils [e.g., soybean oil, rapeseed oil, corn oil, sesame oil, flaxseed oil, safflower oil, sunflower oil, cottonseed oil, nut oils (macadamia nut oil, hazelnut oil, peanut oil, almond oil, walnut oil, etc.), seed oils (grape seed oil, pumpkin seed oil, etc.), lemon oil, camellia oil, tea seed oil, perilla oil, borage oil, olive oil, rice oil, rice bran oil, wheat germ oil, coconut oil, palm oil, palm olein, palm kernel oil, etc.], animal oils (e.g., fish oil, liver oil, whale oil, etc.), and medium-chain triglycerides (MCTs).

[0042] Medium-chain fatty acid triglycerides are usually glycerol triesters of fatty acids with 4 to 12 carbon atoms, and may also contain mixtures consisting mostly of fatty acid triglycerides with these carbon atoms. Such medium-chain fatty acid triglycerides are not particularly limited, but examples include those mainly composed of fatty acid triglycerides with 8 carbon atoms (caprylic acid) or 10 carbon atoms (capric acid), obtained by hydrolyzing and refining coconut oil, palm kernel oil, etc., and then recombining them.

[0043] The acids constituting the ester oil are not particularly limited and may be fatty acids or non-fatty acids (aromatic carboxylic acids). The fatty acids may be saturated fatty acids or unsaturated fatty acids. The acids may also be monocarboxylic acids or polycarboxylic acids. The acids constituting the ester oil may be used individually or in combination of two or more types.

[0044] The alcohols constituting the ester oil may be monools or polyols. The alcohols constituting the ester oil may be used individually or in combination of two or more types.

[0045] When the acid constituting the ester oil is a polycarboxylic acid and / or the alcohol constituting the ester oil is a polyol, the ester may be a monoester or a polyester.

[0046] Specific examples of ester oils include monocarboxylic acid esters {for example, saturated fatty acid esters [for example, acetate esters (e.g., amyl acetate, etc.), caprylic acid esters (e.g., cetyl caprylate, ethylene glycol dioctanoate, neopentyl glycol dioctanoate, cetyl octanoate, etc.), isooctanoic acid esters (e.g., glyceryl triisooctanoate, etc.), 2-ethylhexanoic acid esters (e.g., stearyl 2-ethylhexanoate, isostearyl 2-ethylhexanoate, cetostearyl 2-ethylhexanoate, 2-ethylhexanoate, ethylhexanoic acid Cetyl acid, glyceryl tri-2-ethylhexanoate, ethylene glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, etc.), isononanoate esters (e.g., 2-ethylhexyl isononanoate, isononyl isononanoate, isododecyl isononanoate, isotridecyl isononanoate, cetostearyl isononanoate, etc.), caprate esters (e.g., diethylene glycol dicaprate, neopentyl glycol dicaprate, etc.), laurate esters (e.g., laurin (e.g., hexyl acid, glyceryl dilaurate), myristic acid esters (e.g., isopropyl myristate, butyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, glyceryl dimyristate, glycerin trimyristate, etc.), palmitic acid esters (e.g., isopropyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cetyl palmitate, ethylene glycol palmitate, etc.), isopalmitic acid esters (e.g., glyceryl triisopalmitate, etc.), stearin Acid esters (e.g., butyl stearate, batyl stearate, isocetyl stearate, etc.), isostearate esters (e.g., ethyl isostearate, isopropyl isostearate, isostearyl isostearate, hexyldecyl isostearate, octyldodecyl isostearate, isocetyl isostearate, batyl isostearate, propylene glycol isostearate, etc.), unsaturated fatty acid esters (e.g., oleate esters (e.g., ethyl oleate, 2-octyldodecyl oleate, decyl oleate,Fatty acid esters (aliphatic monocarboxylic acid esters) such as oleyl oleate, propylene glycol oleate, etc., linoleic acid esters (e.g., isopropyl linoleate, etc.), erucic acid esters (e.g., octyldodecyl erucate, oleyl erucate, etc.), polycarboxylic acid esters [e.g., succinic acid esters (e.g., di-2-ethylhexyl succinate, etc.), adipic acid esters (e.g., diisopropyl adipate, dibutyl adipate, diisobutyl adipate, di-2-ethylhexyl adipate, di-2-hexyl adipate] Examples include aliphatic polycarboxylic acid esters such as rudecyl, di-2-heptylundecyl adipate, 2-hexyldecyl adipate, etc., sebacate esters (e.g., diethyl sebacate, isopropyl sebacate, diisopropyl sebacate, di-2-ethylhexyl sebacate, etc.), oxycarboxylic acid esters (e.g., lactate esters (e.g., cetyl lactate, myristyl lactate, etc.), malic acid esters (e.g., diisostearyl malate, etc.), and citrate esters (e.g., triethyl citrate, etc.), etc.).

[0047] Polar oils may be used alone or in combination of two or more types.

[0048] Of these, adipates (e.g., diisobutyl adipate, di-2-ethylhexyl adipate, dibutyl adipate), isooctanoates [e.g., glyceryl triisooctanoate (glyceride triisooctanoate)], isononanoates (e.g., isononyl isononanoate), myristicates (e.g., isopropyl myristate), palmitates (e.g., isopropyl palmitate), isostearates (e.g., batyl isostearate), sebacates (e.g., diethyl sebacate), medium-chain triglycerides, higher fatty acids (e.g., isostearic acid), and higher alcohols (e.g., octyldodecanol) may be used particularly favorably.

[0049] The above are just examples, and polar oils (or liquid oils) are not limited to the compounds exemplified above. Furthermore, components listed later as optional components (for example, tocopherol acetate, phenoxyethanol, etc.) may also be polar oils if they fall within the concept of polar oils (or liquid oils).

[0050] It is preferable to select polar oils such that their IOB values ​​fall within a predetermined range. For example, the IOB value (total IOB value) of the polar oil (the polar oil as a whole) may be 0.12 or higher (e.g., 0.12~0.60, 0.12~0.50, 0.12~0.46), preferably 0.15 or higher (e.g., 0.15~0.60, 0.15~0.50, 0.15~0.46), and more preferably 0.20 or higher [e.g., 0.20~0.60, 0.20~0.50, 0.20~0.46, 0.22 or higher (e.g., 0.23~0.60, 0.23~0.50, 0.23~0.46), 0.25 or higher (e.g., 0.26~0.60, 0.26~0.50, 0.26~0.46, etc.)].

[0051] Note that when two or more polar oils are combined, the above IOB value is the IOB value of the entire polar oil (arithmetic mean of IOB values). For example, if polar oil A with an IOB value of 0.2 and polar oil B with an IOB value of 0.3 are combined in a mass ratio of 40 / 60, the IOB value of the entire polar oil will be 0.26 (0.2 × 0.4 + 0.3 × 0.6).

[0052] By setting the IOB value of the polar oil within the range described above, the effects of the present invention (for example, improved solubility, improved transparency and uniformity, improved moisturizing properties and usability, etc.) can be efficiently achieved. Furthermore, it offers advantages in terms of safety.

[0053] The polar oil may contain at least one polar oil having a predetermined IOB value. For example, the polar oil may contain a polar oil with an IOB value of 0.12 or higher [e.g., 0.12-0.80, 0.12-0.60, 0.12-0.55, 0.12-0.50, 0.14 or higher (e.g., 0.15-0.80, 0.15-0.60, 0.15-0.55, 0.15-0.50), 0.18 or higher (e.g., 0.18-0.80, 0.18-0.60, 0.18-0.55, 0.18-0.50), etc.].

[0054] By using polar oils having such predetermined IOB values, the effects of the present invention (for example, improved solubility, improved transparency and uniformity, improved moisturizing properties and usability, etc.) can be efficiently achieved. Furthermore, it offers advantages in terms of safety.

[0055] Polar oils may preferably be used in combination of two or more types, and particularly in combination of three or more types. By combining oils with different IOB values, it is possible to more efficiently obtain transparent or uniform compositions, compositions with excellent usability, and so on.

[0056] In such combinations, it is particularly preferable that the overall IOB value of the polar oils is within the aforementioned range (for example, 0.12 or higher, 0.15 or higher, 0.16 or higher, 0.18 or higher, etc.). In such cases, the polar oils to be used and the blending ratios of each polar oil may be selected so that the IOB value falls within the aforementioned range.

[0057] The IOB value is an abbreviation for Inorganic / Organic Balance, and it represents the ratio of inorganic values ​​to organic values, serving as an indicator of the degree of polarity of an organic compound. Specifically, the IOB value is expressed as IOB value = inorganic value / organic value. For each of the "inorganic value" and "organic value," for example, one carbon atom in a molecule has an "organic value" of 20, and one hydroxyl group has an "inorganic value" of 100. These values ​​are set according to various atoms or functional groups, and the IOB value of an organic compound can be calculated by summing the "inorganic value" and "organic value" of all atoms and functional groups in the organic compound (see, for example, Yoshio Koda, "Organic Concept Diagram - Fundamentals and Applications," pp. 11-17, Sankyo Publishing, 1984).

[0058] For reference, the following table shows examples of IOB values ​​for polar oils.

[0059] [Table 1]

[0060] The content of component (B) in the composition can be selected according to the intended use of the composition, but may be, for example, 40% by mass or more, preferably 50% by mass or more, more preferably 60% by mass or more, even more preferably 65% ​​by mass or more, and most preferably 75% by mass or more, relative to the total amount of the composition. The upper limit of the content of component (B) in the composition is not particularly limited, but may be, for example, 95% by mass, 93% by mass, 91% by mass, 89% by mass, etc.

[0061] If component (B) contains component (B1) (non-polar oil), the amount of component (B1) in the composition can be selected according to the intended use of the composition, but may be, for example, 80% by mass or less, preferably 60% by mass or less, more preferably 50% by mass or less, and most preferably 40% by mass or less, relative to the total amount of the composition, or it may be 30% by mass or less (for example, 25% by mass or less, 20% by mass or less). The lower limit of the content of component (B1) is not particularly limited, but may be, for example, 0.5% by mass, 1% by mass, 2% by mass, 3% by mass, 5% by mass, 10% by mass, 15% by mass, etc., relative to the total amount of the composition.

[0062] If component (B) contains component (B1), the proportion of component (B1) may be, for example, 0.1 to 60% by mass, preferably 1 to 50% by mass, more preferably 1.5 to 45% by mass, even more preferably 1.5 to 35% by mass, and most preferably about 2 to 30% by mass, relative to the total amount of component (B).

[0063] When component (B) contains component (B1) and component (B2) (polar oil), the ratio of component (B1) to component (B2) can be selected from a range of approximately 100 parts by mass or less (for example, 50 parts by mass or less) of component (B1) per 1 part by mass of component (B2), for example, 30 parts by mass or less (for example, 10 parts by mass or less), preferably 5 parts by mass or less (for example, 3 parts by mass or less), and more preferably 2 parts by mass or less (for example, 1.5 parts by mass or less). 1.2 parts by mass or less (for example, 1.1 parts by mass or less, 1.06 parts by mass or less, 1.05 parts by mass or less, 1.02 parts by mass or less, 1 part by mass or less, 0.95 parts by mass or less, 0.9 parts by mass). 0.85 parts by mass or less, 0.8 parts by mass or less, 0.75 parts by mass or less, 0.7 parts by mass or less, 0.65 parts by mass or less, 0.6 parts by mass or less, 0.5 parts by mass or less, 0.45 parts by mass or less). The lower limit is not particularly limited, but for example, it may be 0.005 parts by mass, 0.0075 parts by mass, 0.05 parts by mass, or 0.1 parts by mass of component (B1) per 1 part by mass of component (B2). In this way, by selecting the ratio of component (B1) to component (B), the effects of the present invention (for example, improved solubility, improved transparency and uniformity, improved moisturizing properties and usability, etc.) can be efficiently achieved.

[0064] If component (B) contains component (B2) (polar oil), the amount of component (B2) in the composition can be selected according to the intended use of the composition, but may be, for example, 30% by mass or more, preferably 40% by mass or more, more preferably 50% by mass or more, and most preferably 55% by mass or more, relative to the total amount of the composition. Furthermore, the upper limit of the content of component (B2) may be, for example, 89% by mass, 86% by mass, 83% by mass, 80% by mass, 70% by mass, 60% by mass, etc., relative to the total amount of the composition.

[0065] If component (B) contains component (B2) (polar oil), the proportion of component (B2) may be, for example, 40 to 10,000 parts by mass (for example, 45 to 5,000 parts by mass, 50 to 1,000 parts by mass), preferably 100 to 900 parts by mass, more preferably 150 to 800 parts by mass, and even more preferably 160 to 400 parts by mass, per 1 part by mass of component (A).

[0066] If component (B2) contains a polar oil with an IOB value of 0.12 or higher, the proportion of the polar oil with an IOB value of 0.12 or higher in the composition may be, for example, 5% by mass or more, preferably 10% by mass or more, more preferably 15% by mass or more, and most preferably 20% by mass or more. Furthermore, the upper limit for the content of polar oils with an IOB value of 0.12 or higher may be, for example, 80% by mass, 75% by mass, 70% by mass, 65% by mass, etc., relative to the total amount of the composition.

[0067] If component (B2) contains a polar oil with an IOB value of 0.12 or higher, the proportion of the polar oil with an IOB value of 0.12 or higher to the total component (B) may be, for example, 10% by mass or more, preferably 20% by mass or more, more preferably 30% by mass or more, and most preferably 35% by mass or more. Furthermore, the upper limit for the content of polar oils with an IOB value of 0.12 or higher may be, for example, 95% by mass, 90% by mass, 85% by mass, 80% by mass, etc., relative to the total amount of component (B).

[0068] (C) Surfactants ((C) Components) The composition of the present invention may contain a surfactant. Examples of surfactants include nonionic surfactants. By including a surfactant, the effects of the present invention (for example, improved solubility, improved transparency and uniformity, improved moisturizing properties and usability, etc.) can be efficiently achieved. In particular, it is advantageous in terms of improving or maintaining transparency and uniformity (storage stability).

[0069] Nonionic surfactants include polyglyceryl-2 oleate, polyglyceryl-10 pentaoleate, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 stearate, polyglyceryl-10 isostearate, polyglyceryl-10 oleate, polyglyceryl-10 distearate, polyglyceryl-10 diisostearate, polyglyceryl-10 tristearate, polyglyceryl-10 trioleate, polyglyceryl-10 pentastearate, polyglyceryl-10 pentahydroxystearate, polyglyceryl-10 pentaisostearate, polyglyceryl-10 pentaoleate, polyglyceryl-10 decaoleate, polyglyceryl-2 stearate, and polyglyceryl-10 isostearate. Polyglycerin fatty acid esters such as ligceryl-2, polyglyceryl-6 myristate, polyglyceryl-6 laurate, polyglyceryl-6 stearate, polyglyceryl-6 tristearate, polyglyceryl-6 pentastearate, polyglyceryl-4 oleate, and polyglyceryl-6 stearate; PEG [polyethylene glycol or polyoxyethylene (POE)] hydrogenated castor oil (POE hydrogenated castor oil) such as PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, and PEG-100 hydrogenated castor oil; POE castor oil 3, POE castor oil 4, POE castor oil 6, POE castor oil 7, POE castor oil 10, and POE castor oil 13.5. POE castor oil such as POE castor oil 17, POE castor oil 20, POE castor oil 25, POE castor oil 30, POE castor oil 35, POE castor oil 40, POE castor oil 50; sorbitan fatty acid esters such as sorbitan sesquioleate, sorbitan laurate, sorbitan palmitate, sorbitan stearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan isostearate, sorbitan sesquiisostearate, sorbitan oleate, sorbitan trioleate; POE(20) sorbitan monolaurate (POE Polysorbates (POE sorbitan fatty acid esters) such as polysorbate 20), POE(20) sorbitan monopalmitate (polysorbate 40), POE(20) sorbitan monostearate (polysorbate 60), POE(20) sorbitan tristearate (polysorbate 65), POE(20) sorbitan monooleate (polysorbate 80), POE(20) sorbitan trioleate (polysorbate 85); POEPOP glycol (196 E.O.) (67 P.O.) (or polyoxyethylene (196) polyoxypropylene ( 67) Glycol, the same applies in the following expressions, poloxamer 407), POEPOP glycol (20 E.O.) (20 P.O.), POEPOP glycol (42 E.O.) (67 P.O.) (poloxamer 403), POEPOP glycol (54 E.O.) (39 P.O.) (poloxamer 235), POEPOP glycol (124 E.O.) (39 P.O.), POEPOP glycol (160 E.O.) (30 P.O.), POEPOP glycol (200 E.O.) (70 P.O.), POEPOP glycol (30 E.O.) (150 POE / POP glycols such as P.O. (Poloxamer 188); polyethylene glycol monostearate (2 E.O.), polyethylene glycol monostearate (4 E.O.), polyethylene glycol monostearate (9 E.O.), polyethylene glycol monostearate (10 E.O.), polyethylene glycol monostearate (23 E.O.), polyethylene glycol monostearate (25 E.O.), polyethylene glycol monostearate (32 E.O.), polyethylene glycol monostearate (40 E.O.)Examples include polyethylene glycol monostearate such as polyoxyl stearate (40), polyethylene glycol monostearate (45 E.O.), polyethylene glycol monostearate (55 E.O.), polyethylene glycol monostearate (75 E.O.), and polyethylene glycol monostearate (140 E.O.); POE alkyl ethers such as POE(9) lauryl ether; POE-POP alkyl ethers such as POE(20)POP(4) cetyl ether; and POE alkylphenyl ethers such as POE(10) nonylphenyl ether. In the compounds exemplified above, POE represents polyoxyethylene, POP represents polyoxypropylene, and the number in parentheses indicates the number of moles added.

[0070] In particular, POE castor oil (e.g., POE castor oil 20, POE castor oil 40), polysorbates (e.g., POE(20) sorbitan trioleate, polysorbate 85, polysorbate 80, polysorbate 65, polysorbate 60, etc.), polyglycerin fatty acid esters, etc., may be suitably used.

[0071] Surfactants may be used alone or in combination of two or more types.

[0072] If the composition of the present invention contains a surfactant (particularly a nonionic surfactant), the proportion of component (C) may be, for example, 0.5 to 30% by mass, preferably 1 to 20% by mass, more preferably 2 to 15% by mass, even more preferably 3 to 12% by mass, and most preferably 3 to 10% by mass) of the total amount of the composition.

[0073] If the composition of the present invention contains a surfactant (particularly a nonionic surfactant), the proportion of component (C) may be, for example, 1 to 400 parts by mass (for example, 1 to 200 parts by mass), preferably 3 to 150 parts by mass, more preferably 5 to 100 parts by mass, even more preferably 5 to 80 parts by mass, and most preferably about 6 to 40 parts by mass, per 1 part by mass of component (A).

[0074] If the composition of the present invention contains a surfactant (particularly a nonionic surfactant), the proportion of component (C) may be, for example, 0.02 to 1 part by mass, preferably 0.03 to 0.75 parts by mass, more preferably 0.04 to 0.5 parts by mass, and even more preferably 0.04 to 0.3 parts by mass, per 1 part by mass of component (B). With this ratio, component (C) is more likely to exert its function efficiently.

[0075] (D) Component The composition of the present invention may contain one or more selected from (D1) phospholipids and (D2) sterols. Including such (D) components can efficiently achieve the effects of the present invention (for example, improved solubility, improved transparency and uniformity, improved moisturizing properties and feel, etc.). In particular, it is advantageous in terms of improving or maintaining transparency and uniformity (storage stability). For example, the (D1) phospholipid can function as a binder between the hydrophilic (A) component (and even (E) component) and component (B) in the presence of component (C). In particular, the (D1) phospholipid can form an interface (interfacial film) between the phase containing component (A) and component (B). For this reason, using component (D1) makes it easier to obtain compositions that are advantageous in terms of transparency, etc. (D2) Sterols can also function similarly to (D1) components, which may explain why it is easier to obtain compositions that are advantageous in terms of transparency, etc. In particular, component (D2), when used in combination with component (D1), can reinforce component (D1) [for example, the (D1) phospholipid can reinforce the interface (interfacial film) containing component (D1) formed between the phase where component (A) exists and component (B)], making it easier to obtain a stable composition, and consequently, a composition that is even more advantageous in terms of transparency and other aspects. From this viewpoint, the composition of the present invention may preferably contain (D1) phospholipids and (D2) sterols.

[0076] (D1) Phospholipids (D1 component) Phospholipids can be any type commonly used as cosmetic ingredients, including natural lecithins extracted from plants and animals such as soybeans, egg yolks, corn, and rapeseed, as well as microorganisms such as E. coli, and their hydrogenated derivatives, and synthetic lecithins. Specifically, examples include lecithins [e.g., plant lecithin (soybean lecithin, etc.), egg yolk lecithin, and their hydrogenated versions], phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, sphingophospholipids, sphingolipids (e.g., sphingomyelin), phosphatidic acid, lysophosphatidylcholine, and the like. Among these, lecithins are preferred, and plant-derived lecithins are more preferred. Phospholipids may be used alone or in combination of two or more types.

[0077] (D2) Sterols (D2 component) Any sterols commonly used as cosmetic ingredients are acceptable, specifically including cholesterol and phytosterols. Sterols may be used individually or in combination of two or more types.

[0078] Component (D) may be used alone or in combination of two or more types, and in particular, component (D1) and component (D2) may be used in combination.

[0079] If the composition of the present invention contains component (D), the proportion of component (D) may be, for example, 0.005% by mass or more (e.g., 0.01 to 7% by mass), preferably 0.03% by mass or more (e.g., 0.05 to 5% by mass), more preferably 0.07% by mass or more (e.g., 0.1 to 4% by mass), and most preferably 0.12% by mass or more (e.g., 0.15 to 3% by mass) with respect to the total amount of the composition.

[0080] If the composition of the present invention contains component (D1), the proportion of component (D1) may be, for example, 0.005% by mass or more (e.g., 0.01 to 5% by mass), preferably 0.03% by mass or more (e.g., 0.05 to 4% by mass), more preferably 0.07% by mass or more (e.g., 0.1 to 3% by mass), and most preferably 0.12% by mass or more (e.g., 0.15 to 2% by mass) with respect to the total amount of the composition.

[0081] If the composition of the present invention contains component (D2), the proportion of component (D2) may be, for example, 0.005% by mass or more (e.g., 0.01 to 5% by mass), preferably 0.015% by mass or more (e.g., 0.02 to 3% by mass), more preferably 0.025% by mass or more (e.g., 0.03 to 1% by mass), and most preferably 0.04% by mass or more (e.g., 0.05 to 0.5% by mass) with respect to the total amount of the composition.

[0082] When combining component (D1) and component (D2), the ratio of these components may be, for example, (D1) component / (D2) component (mass ratio) = 10000 / 1 to 0.0001 / 1, preferably 1000 / 1 to 0.001 / 1, and more preferably 100 / 1 to 0.01 / 1 (for example, 50 / 1 to 0.02 / 1). Alternatively, component (D1) may be present in a relatively large proportion, such as 10000 / 1 to 0.1 / 1 (for example, 10000 / 1 to 0.5 / 1, preferably 1000 / 1 to 0.8 / 1, 500 / 1 to 1 / 1, 100 / 1 to 1.5 / 1, 50 / 1 to 2 / 1, 10 / 1 to 3 / 1). With this ratio of component (D1) to component (D2), both components can efficiently exert their functions.

[0083] If the composition of the present invention contains component (D), the proportion of component (D) may be, for example, 0.1 to 60 parts by mass (for example, 0.2 to 25 parts by mass), preferably 0.5 to 20 parts by mass, more preferably 1 to 15 parts by mass, and even more preferably 1.5 to 10 parts by mass, per 1 part by mass of component (A). If the composition of the present invention contains component (D), the proportion of component (D) may be, for example, 0.001 to 0.06 parts by mass, 0.002 to 0.03 parts by mass, preferably 0.003 to 0.01 parts by mass, more preferably 0.001 to 15 parts by mass, and even more preferably about 1.5 to 10 parts by mass, per 1 part by mass of component (B). If the composition of the present invention contains component (D), the proportion of component (C) may be, for example, 0.01 to 10 parts by mass, 0.02 to 8 parts by mass, preferably 0.03 to 5 parts by mass, more preferably 0.1 to 3 parts by mass, and even more preferably 0.15 to 1.5 parts by mass, per 1 part by mass of component (A). At this ratio, component (D) is more likely to exert its function efficiently.

[0084] (F) Polyhydric alcohol (component F) The composition of the present invention may contain a polyhydric alcohol. By including polyhydric alcohols, the effects of the present invention (for example, improved solubility, improved transparency and uniformity, improved feel, improved penetration, etc.) can be efficiently achieved. For example, polyhydric alcohols, together with component (D), can function as a binder between the hydrophilic components (A) (and even (E)) and (B) in the presence of component (C), which may make the composition even more advantageous in terms of transparency, etc. Furthermore, as will be discussed later, polyhydric alcohols can also function (be used) as moisturizing ingredients and carriers. Examples of polyhydric alcohols include alkanediols (e.g., propylene glycol, 1,3-butylene glycol, pentanediol, isoprene glycol, etc.), polyalkanediols (e.g., dipropylene glycol, polyethylene glycol), and polyols having three or more hydroxyl groups [e.g., glycerin, diglycerin, sugars, or sugar alcohols (e.g., trehalose, etc.)]. In particular, glycerin may be preferably used. Polyhydric alcohols may be used alone or in combination of two or more types.

[0085] If the composition of the present invention contains a polyhydric alcohol, the proportion of component (F) may be, for example, 0.05% by mass or more (e.g., 0.1 to 15% by mass), preferably 0.2% by mass or more (e.g., 0.3 to 10% by mass), more preferably 0.4% by mass or more (e.g., 0.5 to 5% by mass), and most preferably 0.7% by mass or more (e.g., 0.8 to 3% by mass, 0.8 to 2.5% by mass) with respect to the total amount of the composition.

[0086] If the composition of the present invention contains a polyhydric alcohol, the proportion of component (F) may be selected from a range of approximately 300 parts by mass or less (for example, 200 parts by mass or less) per 1 part by mass of component (A), for example, 100 parts by mass or less (for example, 50 parts by mass or less, 30 parts by mass or less), preferably 20 parts by mass or less, more preferably 10 parts by mass or less, and may also be 1 part by mass or more, 2 parts by mass or more, 5 parts by mass or more, 8 parts by mass or more, 10 parts by mass or more, etc. With this ratio, the function of component (F) is more easily exerted efficiently.

[0087] Active ingredients The composition of the present invention may optionally contain active ingredients (ingredients other than mucopolysaccharides). Specific examples of active ingredients include, for example, moisturizing ingredients, anti-inflammatory ingredients, antibacterial ingredients, vitamins, peptides or their derivatives, amino acids or their derivatives, cell-activating ingredients, anti-aging ingredients, blood circulation-promoting ingredients, keratin-softening ingredients, whitening ingredients, astringent ingredients, and UV-protective ingredients.

[0088] Examples of moisturizing ingredients include polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, diglycerin, and trehalose; high molecular weight compounds such as collagen, elastin, keratin, chitin, and chitosan; amino acids such as glycine, aspartic acid, and arginine; natural moisturizing factors such as sodium lactate, urea, and sodium pyrrolidone carboxylate; lipids such as ceramides, cholesterol, and phospholipids; and plant extracts such as chamomile extract, witch hazel extract, tea extract, and perilla extract.

[0089] Examples of anti-inflammatory ingredients include components derived from plants (e.g., comfrey), allantoin, glycyrrhizic acid or its derivatives, zinc oxide, pyridoxine hydrochloride, tocopherol acetate, salicylic acid or its derivatives, and ε-aminocaproic acid.

[0090] Examples of antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, parabens, phenoxyethanol, 1,2-pentanediol, and alkyldiaminoglycine hydrochloride.

[0091] Vitamins include vitamin E derivatives such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate; vitamin B2 derivatives such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, and riboflavin tetranicotinate; and dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, and β-butyrate nicotinate. Nicotinic acids such as oxyethyl nicotinate and 1-(4-methylphenyl)ethyl nicotinate; vitamin C compounds such as ascorbigen-A, ascorbic acid stearate, ascorbic acid palmitate, and L-ascorbyl dipalmitate; vitamin D compounds such as methyl hesperidin, ergocalciferol, and cholecalciferol; vitamin K compounds such as phylloquinone and farnoquinone; γ-oryzanol, dibenzoylthiamine, dibenzoylthiamine hydrochloride; thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, and thiamine lauryl salt Vitamin B1s such as salts, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate; Vitamin B6s such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, pyridoxal 5'-phosphate, pyridoxamine hydrochloride; Vitamin B1s such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin Vitamin B12s; folic acid derivatives such as folic acid and pteroylglutamic acid; nicotinic acid derivatives such as nicotinic acid and nicotinamide; pantothenic acid derivatives such as pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesine, D-pantethine, coenzyme A, and pantothenyl ethyl ether; biotin derivatives such as biotin and biotisine; vitamin C derivatives such as ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate, and magnesium ascorbate phosphate;Examples include vitamin-like factors such as carnitine, ferulic acid, alpha-lipoic acid, orotic acid, and pyrroloquinoline quinone.

[0092] Examples of peptides or their derivatives include keratin-degrading peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptides, collagen-degrading peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptides, conchiolin-degrading peptides, hydrolyzed conchiolin, silk protein-degrading peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein-degrading peptides, hydrolyzed soy protein, wheat protein, wheat protein-degrading peptides, hydrolyzed wheat protein, casein-degrading peptides, and acylated peptides (such as palmitoyl oligopeptides, palmitoyl pentapeptides, and palmitoyl tetrapeptides).

[0093] Examples of amino acids or their derivatives include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine.

[0094] Cell-activating components include amino acids such as γ-aminobutyric acid and ε-aminopronic acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; and tannins, flavonoids, saponins, allantoin, and photosensitizer 301.

[0095] Anti-aging ingredients include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

[0096] Examples of blood circulation-promoting ingredients include those derived from plants (for example, ginseng, angelica tree, arnica, ginkgo, fennel, laurel, watercress, chamomile, Roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, European hawthorn, European juniper, cinnamon, gentian, thyme, clove, dried tangerine peel, angelica, peach kernel, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, lemon balm, yuzu, coix seed, rosemary, rosehip, peach, apricot, walnut, corn); glucosyl hesperidin, etc.

[0097] Examples of keratin-softening ingredients include salicylic acid, glycolic acid, fruit acids, phytic acid, and sulfur.

[0098] Examples of skin-whitening ingredients include ascorbic acid and its derivatives, arbutin, tocopherol, and tranexamic acid.

[0099] Examples of astringent ingredients include zinc paraphenolsulfonate, menthol, and ethanol.

[0100] Examples of UV protection ingredients include 2-ethylhexyl paramethoxycinnamate, hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, t-butyl methoxydibenzoylmethane, ethylhexyl dibenzylidene dioxoimidazolidine propyronate, etorhexyl triazoline, para-aminobenzoic acid and its derivatives, octyl paradimethylaminobenzoate, ethylene glycol salicylate, and dihydroxybenzophenone.

[0101] The active ingredients may be used alone or in combination of two or more.

[0102] additives The composition of the present invention may optionally contain additives such as antioxidants, preservatives, thickeners, pH adjusters, irritation reducers, colorants, fragrances, chelating agents, and the like.

[0103] Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, and L-cysteine ​​hydrochloride.

[0104] Examples of preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, alkanediol, and glycerin fatty acid esters.

[0105] Examples of thickeners include water-soluble polymers and oil-soluble polymers. More specifically, water-soluble polymers include guar gum, locust bean gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl acrylate methacrylate copolymer, polyethylene glycol, (hydroxyethyl acrylate / sodium acryloyldimethyltaurate) copolymer, (ammonium acryloyldimethyltaurate / vinylpyrrolidone) copolymer, and component (A) of the above examples (e.g., dextran sulfate component). Examples of oil-soluble polymers include ethylcellulose and dextrin palmitate.

[0106] Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.), and organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.).

[0107] Examples of irritation-reducing agents include licorice extract and sodium alginate.

[0108] Examples of colorants include those listed in the Legal Colorants Handbook (compiled by the Japan Cosmetic Industry Association (2004), etc.).

[0109] Examples of fragrances include herbal essential oils such as lavender oil, rosemary oil, clary sage oil, thyme oil, bergamot oil, and eucalyptus oil; mint essential oils such as peppermint oil, spearmint oil, and peppermint oil; and various citrus essential oils such as orange oil, lemon oil, and grapefruit oil, as well as blended fragrances.

[0110] Examples of chelating agents include EDTA or its salts (e.g., EDTA-2 sodium salt, EDTA-3 calcium-2 sodium salt), and sugar alcohols (e.g., sorbitol, xylitol, erythritol, mannitol).

[0111] Additives may be used individually or in combination of two or more types.

[0112] Base or carrier In the composition of the present invention, the liquid oil may function as a base or carrier of the composition, and may optionally contain a base or carrier (another base or carrier).

[0113] Examples of bases or carriers include water, physiological saline, lower alcohols (e.g., ethanol, isopropanol), polyhydric alcohols (e.g., glycerin, propylene glycol, polyethylene glycol (macrogol), 1,3-butylene glycol, isoprene glycol, dipropylene glycol, and other polyhydric alcohols), poloxamers, and semi-solid to solid oils (e.g., petrolatum, polyethylene, microcrystalline wax, etc.). Furthermore, semi-solid or solid oils may be oils that do not fall under the concept of liquid oil as exemplified above. Also, depending on their type, such components may impart functions to the composition other than those of a base or carrier (for example, when petrolatum is used to improve the feel of the product). Examples of poloxamers include POE-POP glycols such as POEPOP glycol (196 E.O.) (67 P.O.) (or polyoxyethylene (196) polyoxypropylene (67) glycol, the same applies hereafter in similar expressions, poloxamer 407), POEPOP glycol (20 E.O.) (20 P.O.), POEPOP glycol (42 E.O.) (67 P.O.) (poloxamer 403), POEPOP glycol (54 E.O.) (39 P.O.) (poloxamer 235), POEPOP glycol (124 E.O.) (39 P.O.), POEPOP glycol (160 E.O.) (30 P.O.), POEPOP glycol (200 E.O.) (70 P.O.), and POEPOP glycol (30 E.O.) (150 P.O.) (poloxamer 188).

[0114] Since the compositions of the present invention are usually in liquid form (liquid formulation), at least a liquid base may be suitably used as the base or carrier.

[0115] The base or carrier may be used alone or in combination of two or more types.

[0116] In particular, the composition of the present invention may contain water (component (E)). Component (A) (such as heparinoid) is usually water-soluble. Therefore, in compositions containing water (oil-based compositions), an oil phase and an aqueous phase exist, and component (A) is often present (contained) in this aqueous phase. In the present invention, even if component (A) is contained in such an aqueous phase, mucopolysaccharides and the like can be efficiently absorbed transdermally when used as an external composition (topical preparation).

[0117] If the composition contains water, the water content (moisture content) is preferably 15% by mass or less, more preferably 0.5 to 10% by mass, more preferably 0.75 to 5% by mass, and more preferably 1 to 3% by mass, relative to the total composition. Furthermore, a relatively low water content may be acceptable, for reasons such as the need to incorporate larger amounts of surfactants and preservatives that are more irritating to the skin as the water content increases.

[0118] If the composition contains water, the proportion of water may be selected from a range of approximately 300 parts by mass or less (for example, 200 parts by mass or less, 150 parts by mass or less, 100 parts by mass or less) per 1 part by mass of component (A), for example, 0.08 to 100 parts by mass (for example, 0.1 to 50 parts by mass), preferably 0.3 to 40 parts by mass, more preferably 0.5 to 30 parts by mass, particularly preferably 2 to 6 parts by mass, and most preferably about 3 to 5 parts by mass.

[0119] If the composition contains water, the proportion of water may be, for example, 0.001 to 0.15 parts by mass, preferably 0.005 to 0.14 parts by mass, more preferably 0.008 to 0.13 parts by mass, and particularly preferably 0.01 to 0.12 parts by mass, per 1 part by mass of component (B), and may be 0.015 parts by mass or less (for example, 0.015 to 0.10 parts by mass).

[0120] By adjusting the water content as described above, the effects of the present invention (for example, improved solubility, improved transparency and uniformity, improved feel, improved permeability, etc.) can be efficiently achieved.

[0121] Furthermore, as described above, the composition of the present invention may also contain a polyhydric alcohol. In such a case, the proportion of component (F) may be, for example, 0.1 parts by mass or more (for example, 0.5 to 5 parts by mass), preferably 0.7 parts by mass or more (for example, 1 to 3 parts by mass), and more preferably 1.2 parts by mass or more (for example, 1.5 to 2 parts by mass), per 1 part by mass of water (component (E)).

[0122] Properties, uses, and preparation methods of the composition, etc. The composition of the present invention can be prepared by mixing the above-mentioned components. As described above, the composition of the present invention is composed of a liquid oil that functions as a base or carrier, so a composition with desired properties can be obtained simply by mixing the components.

[0123] The properties of the composition of the present invention are not particularly limited, but may usually be liquid. Examples of liquid states include liquid (liquid preparation), fluid, and gel. The preferred properties of the composition are liquid (liquid preparation). The viscosity of a liquid composition at 25°C may be, for example, 3000 mPa·s or less. The viscosity can be measured at 20°C using, for example, a rotational viscometer (RB80L viscometer, manufactured by Toki Sangyo Co., Ltd.), but it may also be measured using other instruments.

[0124] When the composition of the present invention contains water, the form of the composition (emulsification form) may be either W / O type (water in oil) or O / W type (oil in water), but it may be particularly W / O type.

[0125] Furthermore, if the composition of the present invention has such an aqueous phase and an oil phase, each component may be contained in either phase. Typically, components (A) and (F) may be in the aqueous phase, component (B) in the oil phase, and components (C) and (D) may be in either of these phases or both phases (or at the interface or boundary between these phases).

[0126] The mixing method (preparation method) is not particularly limited and may be selected according to the form of the composition (and even the individual components that make up the composition). For example, all the components may be mixed together, or pre-prepared aqueous and oil phases may be mixed together. In such cases, components (A) and (F) may normally be present (contained) in the aqueous phase, and component (B) in the oil phase. Other components [for example, components (C) and (D)] may be present (contained) in either one or both phases, or they may not be present (contained) in either the aqueous or oil phase, but mixed with these phases. For example, component (C) may be present in either the aqueous phase or the oil phase beforehand, depending on its type (degree of hydrophilicity or hydrophobicity), or it may be present in both phases, or it may be mixed separately with the aqueous phase and the oil phase.

[0127] In particular, the present invention can also yield transparent and uniform compositions.

[0128] Such transparent and homogeneous compositions (and even compositions with excellent storage stability) can be obtained more efficiently by, for example, using component D, selecting the composition and type of liquid oil (for example, using a liquid oil of a specific IOB, or a combination of multiple liquid oils), the composition and type of surfactant, etc.

[0129] The uses of the composition of the present invention are not particularly limited, but it can be used as a topical composition (topical preparation), and especially as a skin composition (topical skin composition).

[0130] Such compositions (external compositions) may be cosmetics, pharmaceuticals (external pharmaceuticals), or quasi-drugs.

[0131] The composition is not particularly limited in form, but examples include liquids, suspensions, emulsions, gels, liniments, lotions, aerosols, and the like.

[0132] Specific forms of compositions include, for pharmaceutical compositions, emulsions, gels, etc., and for quasi-drugs or cosmetic external compositions, examples include basic cosmetics such as lotions, emulsions, gels, creams, serums, sunscreens, packs, masks, and body lotions; cleansing cosmetics such as facial cleansers, makeup removers, body washes, shampoos, conditioners, and treatments; makeup cosmetics such as foundations, makeup bases, lip balms, lipsticks, and blushes; and bath additives.

[0133] container The composition of the present invention may be contained in a container (filled, injected, sealed). The container can be any packaging body having a portion (surface) that comes into contact with the composition (formulation), and may consist of, for example, a container body portion that contains the composition (e.g., a liquid composition), a portion of the container including an outlet (nozzle, inner stopper), a suction tube, a cap, etc.

[0134] The materials that make up the container can be selected from a wide range, for example, at least part or all of the part that comes into contact with the composition may be plastic (e.g., olefin resins, styrene resins, acrylic resins, polyester resins, polycarbonate resins, fluororesins, chlorine resins (such as polyvinyl chloride), polyamide resins, polyacetal resins, polyphenylene ether resins (such as modified polyphenylene ether), polyarylate, polysulfone, polyimide resins, epoxy resins, cellulose resins (such as cellulose acetate), hydrocarbon resins which may be substituted with halogen atoms, etc.), glass, metal (such as aluminum), etc.

[0135] The container may be made of a single material or two or more materials.

[0136] Examples of olefin resins include ethylene resins [for example, polyethylene (including high-density polyethylene, low-density polyethylene, ultra-low-density polyethylene, linear low-density polyethylene, ultra-high molecular weight polyethylene, etc.), ethylene-propylene copolymers, etc.], propylene resins [for example, polypropylene (PP) (including isotactic polypropylene, syndiotactic polypropylene, atactic polypropylene, etc.), propylene-ethylene copolymers, etc.], and methylpentene resins (for example, polymethylpentene, etc.).

[0137] Examples of styrene-based resins include polystyrene and acrylonitrile-containing styrene-based resins (e.g., acrylonitrile-styrene copolymer (AS resin), acrylonitrile-butadiene-styrene copolymer (ABS resin), etc.).

[0138] Examples of acrylic resins include resins that use acrylic acid esters such as methyl acrylate, methacrylate esters such as methyl methacrylate, cyclohexyl methacrylate, and t-butylcyclohexyl methacrylate as polymerization components.

[0139] Examples of polyester resins include aromatic polyester resins [for example, resins having alkylene terephthalate units (alkylene terephthalate resins: for example, polyethylene terephthalate (PET), polytrimethylene terephthalate, polybutylene terephthalate (PBT), etc.), and resins having alkylene naphthalate units (for example, polyethylene naphthalate (PEN), polybutylene naphthalate, etc.)].

[0140] Examples of fluororesins include fluorine-substituted polyethylene (polytetrafluoroethylene, polychlorotrifluoroethylene, etc.), polyvinylidene fluoride, polyvinyl fluoride, perfluoroalkoxy fluororesins, tetrafluoroethylene-hexafluoropropylene copolymer, ethylene-tetrafluoroethylene copolymer, and ethylene-chlorotrifluoroethylene copolymer.

[0141] Polyacetal resins include those consisting solely of oxymethylene units, as well as those containing some oxyethylene units.

[0142] Examples of modified polyphenylene ethers include polystyrene-modified polyphenylene ether.

[0143] Examples of polyarylates include amorphous polyarylates.

[0144] Examples of polyimide resins include aromatic polyimides, such as those obtained by polymerizing pyromellitic dianhydride and 4,4'-diaminodiphenyl ether.

[0145] Examples of cellulose acetates include cellulose diacetate and cellulose triacetate.

[0146] Glass, plastic, and the like are preferred materials for the container. Therefore, at least a part of the container (or the material of the container) may be made of glass, plastic, or the like.

[0147] In particular, plastics such as olefin resins, styrene resins, and polyester resins (i.e., plastic containers) are preferred, ethylene resins, propylene resins, alkylene terephthalate resins, and polystyrene are more preferred, polypropylene, polyethylene terephthalate, and polystyrene are even more preferred, and polyethylene terephthalate (PET) is even more preferred.

[0148] The composition of the present invention can achieve excellent liquid drainage in a relatively wide variety of containers (or their materials, such as glass, plastic, and especially plastics such as PET). In particular, the composition of the present invention can efficiently exhibit excellent liquid drainage in containers made of plastics such as PET.

[0149] The container material may also be a polymer blend with polymers other than the aforementioned polymer. When the container material of the container for containing the composition of the present invention is a blend polymer with the aforementioned polymer, the mixing ratio of the aforementioned polymer to polymers other than the aforementioned polymer is not particularly limited, but it is preferable that the total weight of the aforementioned polymer is 30 w / w% or more, more preferably 50 w / w% or more, even more preferably 65 w / w% or more, and particularly preferably 80 w / w% or more, relative to the total amount of the constituent material.

[0150] The container may have at least a portion of the part (contacting surface) that comes into contact with the composition of the present invention made of the above material. For example, a layer or film made of the above material may be formed on the inner surface of the container, or the container itself may be molded from the above material. From the viewpoint of significantly achieving the effects of the present invention, it is preferable that the container itself is molded from the above material.

[0151] Furthermore, the parts that make up the container (the container body, the part of the container including the dispensing port (nozzle, inner stopper), suction tube, cap, etc.) may be made of the above material, or the entire container may be made of the above material.

[0152] How to use The composition of the present invention may vary depending on the skin condition, age, and gender of the person using it, but it can be used in the following ways, for example. For example, the composition may be applied to the skin in an appropriate amount (for example, about 0.05 to 5 g) several times a day (for example, about 1 to 5 times, preferably 1 to 3 times). Alternatively, the composition may be applied so that the daily amount of component (A) (heparinoid, etc.) is preferably about 0.01 to 100 mg, more preferably about 0.3 to 75 mg. The application period may be, for example, about 1 to 14 days, preferably about 3 to 14 days.

[0153] The compositions of the present invention can be suitably used for the prevention, treatment, and / or improvement of diseases (or symptoms) such as xerosis, dry skin, chilblains, rough hands and fingers, keratosis, cracks in the hands and feet, chapped skin, pruritus, dermatitis, skin hardening after wounds or burns, skin tightness, muscle pain, and joint pain. Therefore, in addition to healthy individuals, people with these skin conditions are suitable users.

[0154] [2. Improvement of transparency and uniformity] The present invention can improve the transparency and uniformity of an oily composition containing component (A).

[0155] Accordingly, the following method is provided as an embodiment of the present invention.

[0156] A method for improving (or enhancing) the transparency and / or uniformity of an oily composition (particularly a liquid oily composition) comprising (A) mucopolysaccharides and (B) liquid oil (and further (C) surfactant), wherein the method is in any one form selected from (1) to (3) below. (1)(B) Liquid oil contains (B1) non-polar oil and (B2) polar oil with an IOB value of 0.05 or higher. (2)(B) Liquid oil is made to contain (B2) polar oil having an IOB value of 0.05 or higher, and the IOB value of (B2) polar oil is set to a predetermined value (for example, 0.12 to 0.50). (3) The composition contains one or more selected from (D)(D1)phospholipids and (D2)sterols.

[0157] In the embodiment of the above method, (1), the ratio of component (B1) to component (B2) may be a predetermined ratio [for example, 1.2 parts by mass or less of component (B1) per 1 part by mass of component (B2)].

[0158] [3. Improvement of storage stability] The present invention can improve the storage stability of an oily composition containing component (A) [for example, maintaining transparency and / or uniformity (over a long period of time), or achieving excellent transparency and / or uniformity even at low temperatures (e.g., below 10°C)].

[0159] Accordingly, the following method is provided as an embodiment of the present invention.

[0160] A method for improving (or enhancing) the storage stability of an oily composition (particularly a liquid oily composition) comprising (A) mucopolysaccharides and (B) liquid oil (and further (C) surfactant) (for example, maintaining transparency and / or uniformity, or achieving transparency and / or uniformity even at low temperatures), wherein the method is in any one form selected from (1) to (3) below. (1)(B) Liquid oil contains (B1) non-polar oil and (B2) polar oil with an IOB value of 0.05 or higher. (2)(B) Liquid oil is made to contain (B2) polar oil having an IOB value of 0.05 or higher, and the IOB value of (B2) polar oil is set to a predetermined value (for example, 0.12 to 0.50). (3) The composition contains one or more selected from (D)(D1)phospholipids and (D2)sterols.

[0161] In the embodiment of the above method, (1), the ratio of component (B1) to component (B2) may be a predetermined ratio [for example, 1.2 parts by mass or less of component (B1) per 1 part by mass of component (B2)].

[0162] [4. Improved moisturizing properties] In the present invention, the moisturizing properties (moisturizing power) of an oily composition containing component (A) can be improved (or enhanced).

[0163] Accordingly, the following method is provided as an embodiment of the present invention.

[0164] A method for improving (or enhancing) the moisturizing properties of an oily composition (particularly a liquid oily composition) comprising (A) mucopolysaccharides and (B) liquid oil (and further (C) surfactant), wherein the method is in any one form selected from (1) to (3) below. (1)(B) Liquid oil contains (B1) non-polar oil and (B2) polar oil with an IOB value of 0.05 or higher. (2)(B) Liquid oil is made to contain (B2) polar oil having an IOB value of 0.05 or higher, and the IOB value of (B2) polar oil is set to a predetermined value (for example, 0.12 to 0.50). (3) The composition contains one or more selected from (D)(D1)phospholipids and (D2)sterols.

[0165] In the embodiment of the above method, (1), the ratio of component (B1) to component (B2) may be a predetermined ratio [for example, 1.2 parts by mass or less of component (B1) per 1 part by mass of component (B2)].

[0166] [5. Improvement of user experience] The present invention can improve (or enhance) the feel of an oily composition containing component (A) (for example, at least one selected from skin compatibility, skin softness, lack of greasiness, lack of stickiness, and penetration).

[0167] Accordingly, the following method is provided as an embodiment of the present invention.

[0168] A method for improving (or enhancing) the feel of an oily composition (particularly a liquid oily composition) comprising (A) mucopolysaccharides and (B) liquid oil (and further (C) surfactant) (for example, at least one selected from skin compatibility, skin softness, lack of greasiness, lack of stickiness, and feeling of penetration), wherein the method is in any one of the following embodiments (1) to (3). (1)(B) Liquid oil contains (B1) non-polar oil and (B2) polar oil with an IOB value of 0.05 or higher. (2)(B) Liquid oil is made to contain (B2) polar oil having an IOB value of 0.05 or higher, and the IOB value of (B2) polar oil is set to a predetermined value (for example, 0.12 to 0.50). (3) The composition contains one or more selected from (D)(D1)phospholipids and (D2)sterols.

[0169] In the embodiment of the above method, (1), the ratio of component (B1) to component (B2) may be a predetermined ratio [for example, 1.2 parts by mass or less of component (B1) per 1 part by mass of component (B2)].

[0170] Furthermore, each of the above embodiments may be combined in combination of two or more forms. For example, when embodiments [2] and [3] are combined, the embodiment includes methods for improving transparency and / or uniformity, as well as storage stability, and when embodiments [2], [3] and [4] are combined, the embodiment includes methods for improving transparency and / or uniformity, storage stability, and moisture retention. Furthermore, the composition of the present invention may have improved compatibility with the skin or stratum corneum. As a result, the composition of the present invention may improve (or enhance) the penetration of component (A). [Examples]

[0171] The present invention will be described in more detail below with reference to examples, but the present invention is not limited in any way by these examples, and many modifications are possible within the technical concept of the present invention by those with ordinary skill in the art.

[0172] [Test Example 1] Evaluation of Transparency and Uniformity 1 A composition (liquid oily composition) with the composition shown in the table below was prepared by a conventional method as described below. The liquid oil (B), surfactant (C), and phospholipid (D1) or sterol (D2) components in the oil phase were mixed by a conventional method to form the oil phase. The components in the aqueous phase, water (E), polyhydric alcohol (F), and component (A) (heparinoid) were mixed to form the aqueous phase. The aqueous phase was added dropwise while stirring the oil phase to obtain the composition.

[0173] Then, the transparency of each composition immediately after preparation under 25°C conditions was visually evaluated. Transparency was measured as follows and evaluated according to the following criteria, with ○ indicating transparent and uniform, and × indicating opaque and non-uniform.

[0174] Transparency and Uniformity: When 30 mL of liquid was filled into a 4 cm diameter cylindrical glass bottle, a bottle was evaluated as transparent if the contents were uniform and a background image (5 mm grid lines printed on paper) could be recognized through the bottle. Opaque and Non-uniform: When 30 mL was filled into a 4 cm diameter cylindrical glass bottle, the contents were evaluated as opaque and non-uniform if they were non-uniform (precipitation, sedimentation, separation, etc.) and / or if the background image (5 mm grid lines printed on paper) could not be recognized through the bottle.

[0175] The results are shown in the table below. Unless otherwise specified, the units for each component in the compositions listed in the table below are in mass percent (the same applies hereafter).

[0176] [Table 2]

[0177] As is clear from the results in the table above, it was found that a transparent composition can be efficiently obtained by combining component (A) with components (B), (C), and (D), or by combining component (A) with a specific component (B) (for example, components (B1) and (B2) in specific ratios, or component (B2) with a specific total IOB value) and component (C).

[0178] [Test Example 2] Evaluation of Transparency and Uniformity 2 The compositions listed in the table below that were transparent after preparation were selected (compositions for Test Examples 1F, 1G, 1H, and 1I), and their transparency and uniformity at low temperatures, as well as the maintenance of transparency and uniformity (storage stability), were further evaluated.

[0179] Transparency at low temperatures was evaluated using SANYO MEDICOOL, MPR-311D(H), after standing for 7 days at 4°C, using the same criteria as in Test Example 1 ("○" for transparent and uniform, "×" for opaque and non-uniform).

[0180] [Table 3]

[0181] As is clear from the results in the table above, the transparency after preparation can be achieved and maintained sufficiently even at low temperatures. Furthermore, it was found that composition 1I could maintain its transparency and uniformity even after standing for 30 days at 4°C.

[0182] [Test Example 3] Evaluation of moisturizing power The compositions listed in the table below that were transparent after preparation were selected (Composition of Test Example 1D), and the compositions that were not transparent (Test Example 1A) were used as the target. The moisturizing power was then evaluated by five expert panelists as described below.

[0183] After washing the inner side of the human forearm, the subject entered a measurement room with a temperature of 22.5°C and a humidity of 40%. A 2.0 cm x 2.0 cm test area was measured, 10 μL of each composition was applied to the test area, and it was left there for 10 minutes. Then, it was wiped off by pressing with a Kimwipe, and the moisture content of the test area was measured using SKICON-200EX. The rate of increase in moisture content due to each composition was calculated, and the ratio (moisture content increase rate ratio) expressed by the following formula was calculated.

[0184] (Ratio of moisture content increase) = (Moisture content increase of composition in Test Example 1D before and after application) / (Moisture content increase of composition in Test Example 1A before and after application)

[0185] As a result, the ratio of the increase in moisture content was "2.37," indicating that the composition of Test Example 1D, which was transparent, exhibited significantly higher moisturizing power compared to the composition that was not transparent (Composition of Test Example 1A).

[0186] [Test Example 4] Sensory Evaluation In the same manner as in Test Example 3, the compositions from Test Example 1D and Test Example 1A (the subjects) were selected and sensory evaluations were performed as follows.

[0187] For each composition, a panel of experts evaluated its compatibility with the skin, skin softness, lack of greasiness, lack of stickiness, and penetration using a Visual Analog Scale (VAS), and calculated the average score (N=5).

[0188] (User experience evaluation) A: VAS score of 7.5 or higher B: VAS score is between 5.0 and 7.5 C: VAS score between 4.0 and 5.0 D: VAS score is less than 4.0

[0189] Furthermore, the difference in VAS values ​​between the composition of Test Example 1D and the composition of Test Example 1A for each item was calculated using the following formula.

[0190] VAS increase rate (%) = [(VAS value in Test Example 1D) / (VAS value in Test Example 1A) - 1] × 100

[0191] [Table 4]

[0192] As is clear from the results in the table above, the composition of Test Example 1D, which was transparent and uniform, also exhibited superior performance in various aspects of usability. In particular, it showed exceptionally superior results in terms of the absence of glare compared to the composition of Test Example 1A.

[0193] [Examples of formulations] Compositions with the compositions shown in the table below were prepared by the same method as described above.

[0194] [Table 5]

[0195] The compositions in each of the formulation examples showed similar tendencies to the compositions in the test examples regarding transparency, uniformity, etc. [Industrial applicability]

[0196] The present invention provides compositions (oil-based compositions) that are useful as external compositions and the like.

Claims

1. (A) Mucopolysaccharides, (B) Liquid oil, (C) Nonionic surfactants, and (D) A liquid oily composition containing one or more selected from (D1) phospholipids and (D2) sterols, The composition contains 75% by mass or more of component (B), (B) The liquid oil includes (B1) a non-polar oil and (B2) a polar oil with an IOB value of 0.05 or higher. (B2) For every 1 part by mass of polar oil with an IOB value of 0.05 or higher, (B1) non-polar oil is 1.2 parts by mass or less. A liquid oily composition that contains no water or contains water in a proportion of 15% by mass or less.

2. (A) Mucopolysaccharides, (B) Liquid oil, (C) Nonionic surfactants, and (D2) A liquid oily composition containing sterols, The composition contains 75% by mass or more of component (B), (B) The liquid oil includes (B1) a non-polar oil and (B2) a polar oil with an IOB value of 0.05 or higher. A liquid oily composition comprising (B2) 1 part by mass of polar oil having an IOB value of 0.05 or more, and (B1) 1.2 parts by mass or less of non-polar oil.

3. (A) Mucopolysaccharides, (B) Liquid oil, and (C) Contains a nonionic surfactant, The composition contains 75% by mass or more of component (B), (B) The liquid oil includes (B1) a non-polar oil and (B2) a polar oil with an IOB value of 0.05 or higher. (B2) For every 1 part by mass of polar oil with an IOB value of 0.05 or higher, (B1) non-polar oil is 1.2 parts by mass or less. A method for improving at least one of the following properties of a liquid oily composition, which contains no water or contains water in a proportion of 15% by mass or less: transparency, uniformity, storage stability, moisturizing properties, and feel. (D) A method for incorporating one or more substances selected from (D1) phospholipids and (D2) sterols into a composition.

4. (A) Mucopolysaccharides, (B) Liquid oil, and (C) Contains a nonionic surfactant, (A) The mucopolysaccharide contains one or more selected from hyaluronic acid, heparin-like substances, chondroitin sulfate, dextran sulfate, and salts thereof. (B) The liquid oil contains (B1) a non-polar oil and (B2) a polar oil with an IOB value of 0.05 or more, and the amount of (B1) non-polar oil is 1.2 parts by mass or less per 1 part by mass of the polar oil with an IOB value of 0.05 or more. A method for improving at least one of the following properties of a liquid oily composition, wherein the content of component (B) in the composition is 75% by mass or more: (D) A method for incorporating (D1) phospholipids and (D2) sterols into a composition, (D1) The phospholipid contains lecithin, (D2) A method comprising sterols containing at least one selected from cholesterol and phytosterols.

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