Cosmetic compositions of liquid crystal lipid particles for personal care applications

Abstract

To provide: a topical composition which effectively improve the skin barrier function by enhancing the skin's own ability to maintain and / or repair the strength of its barrier, so that the protective barrier formed is completely natural; and a skin composition which exhibits enhanced skin protection properties and enhanced skin moisturization.SOLUTION: The presently claimed invention relates to liquid crystal lipid particles. The presently claimed invention relates to liquid crystal lipid particles which are used in a topical composition which has high moisturization efficacy, excellent skin feel, skin softness and skin smoothness benefits. The liquid crystal lipid particles are effective in improving the barrier function and protecting the skin from harmful pollutants, and also enhance the skin moisturizing effect.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to liquid crystal lipid particles. More specifically, the present invention relates to liquid crystal lipid particles used in topical compositions. Topical compositions containing liquid crystal lipid compositions have the advantages of high moisturizing efficacy, excellent skin feel, skin softness, and skin smoothness. [Background technology]

[0002] The skin plays a crucial role as a barrier that prevents the loss of biologically essential components, such as water, while simultaneously protecting against all kinds of biological, chemical, or physical aggression from external microorganisms, chemicals, and ultraviolet radiation. The part that functions as a barrier is the stratum corneum, or keratin layer, which is about 20 μm thick and located in the outermost layer of the skin. It forms a tough barrier membrane in the structure of keratinocytes, which are stacked like bricks, bound together by intercellular lipids that act as mortar.

[0003] The stratum corneum plays a crucial barrier function, its most important being to prevent excessive transepidermal water loss (TEWL). In addition to slowing TEWL, the lipid lamellar membrane sheet also provides protection against the invasion of foreign substances, such as chemicals and microorganisms.

[0004] Emulsifiers that form lamellar liquid crystals are sold by cosmetic ingredient suppliers as mimicking the multi-lamellar lipid structure of the stratum corneum.

[0005] In the field of cosmetics, smaller particles are thought to be more easily absorbed by the skin and to repair damage more easily and efficiently. The introduction of nanotechnology in functional cosmetics aims to make fragrances last longer, sunscreens protect the skin, anti-aging creams combat aging, and moisturizers maintain skin hydration. Some of the innovations based on nanotechnology are nanoemulsions (transparent and possessing unique tactile and texture properties), nanocapsules (used in skincare products), nanopigments (transparent and increasing the efficiency of sunscreen products), liposome formulations (containing vesicles made of conventional cosmetic materials that protect oxygen-sensitive or photosensitive cosmetic ingredients), niosomes, nanocrystals, solid lipid nanoparticles, carbon nanotubes, fullerenes, and dendrimers. Key advantages of using nanoparticles in functional cosmetics include improved stability of cosmetic ingredients (e.g., vitamins, unsaturated fatty acids, and antioxidants) by encapsulation within nanoparticles; efficient protection of the skin from harmful ultraviolet (UV) rays; aesthetically pleasing products (e.g., in mineral sunscreens, using smaller particles of active minerals allows for application without leaving a noticeable white appearance); targeted delivery of active ingredients to desired areas; and controlled release of active ingredients for long-lasting effects.

[0006] WO 2005 / 108383 A1 discloses an oil-in-water emulsion comprising a mixture of at least two sucrose esters combined with at least one solid aliphatic alcohol, wherein the mixture forms a multi-lamellar liquid crystal network that effectively moisturizes and protects the skin and provides a vehicle useful for delivering active ingredients.

[0007] US 2009 / 0239956 A1 relates to a lamellar liquid crystal composition for cosmetic use, which contains one or more polyglycerin monoethers, each having a specific structure, and is used to remove makeup and cosmetics containing cosmetic compositions.

[0008] US 2012 / 0282357 A1 discloses a method of regulating the amount of calcium ions in the epidermis, which includes applying to the skin of a subject a material for improving the skin barrier function, the material being selected from the group consisting of Pimpinella extract, Asteroidea extract, L-carnitine, royal jelly hydrolyzate, α,ε-bis(γ-N-lauroylglutamyl)lysine, Palmaria extract, ε,γ-glutamyllysine, Coptis japonica extract, and citrus aurantium peel extract.

[0009] WO 2016 / 003118 A1 relates to a multiphase cosmetic composition containing cholesteric liquid crystals for improving the feel of use. Rick

[0010] Efforts have been continued to improve the skin barrier function by using some methods such as natural extracts formulated in skin creams, lotions, etc. While these extracts are efficient in biologically improving the skin barrier function, they do not lead to an improvement in the physical barrier function.

Summary of the Invention

Problems to be Solved by the Invention

[0011] Therefore, there still exists a need to effectively improve the skin barrier function by enhancing the ability of the skin itself to maintain and / or repair the strength of its barrier so that the formed protective barrier is completely natural. Furthermore, there is also a need to have a skin composition showing improved skin protection properties and improved skin moisturization.

Means for Solving the Problems

[0012] Surprisingly, it has been found that the liquid crystal lipid particles of the present invention are effective in improving the barrier function and protecting the skin from harmful contaminants, and also in enhancing the skin moisturizing effect.

[0013] ​ Liquid crystalline lipid particles are another type of system that offers the dual advantages of liquid and solid phases. These particles are easily manufactured and can provide numerous advantages.

[0014] Thus, in one aspect, the present invention relates to a method for reducing the adhesion of dust to the skin, which includes applying at least one type of liquid crystalline lipid particle to the skin, and the liquid crystalline lipid particles are at least one compound of formula (I)

[0015] [Chemical formula] [where m is an integer in the range of 10 or more and 24 or less, and n is an integer in the range of 1 or more and 25 or less], at least one compound of formula (II)

[0016] [Chemical formula] [where a is an integer in the range of​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​It is a member of the group or an alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group. and at least one compound of formula (VI)

[0020] [ka] [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, alkah Repayment [It is a member of the group or an alkaline earth metal.] This includes compounds represented by general formulas (I) to (VI), which include [the specified element].

[0021] In yet another aspect, the present invention relates to the use of at least one liquid crystal lipid particle for reducing the adhesion of dust to the skin, Liquid crystal lipid particles are at least one compound of formula (I)

[0022] [ka] [In the formula, m is an integer between 10 and 24, and n is an integer between 1 and 25.] at least one compound of formula (II)

[0023] [ka] [In the formula, a is an integer in the range of 10 to 24.] at least one compound of formula (III)

[0024] [ka] [In the formula, x is an integer between 10 and 24, and y is an integer between 10 and 25.] at least one compound of formula (IV)

[0025] [ka] [In the formula, p is an integer in the range of 10 to 16.] at least one compound of formula (V)

[0026] [ka] [In the formula, A and B are each independently a hydrogen atom or an alkali Repayment It is a member of the group or an alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group, and at least one compound of formula (VI)

[0027] [ka] [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, alkah Repayment [It is a member of the group or an alkaline earth metal.] This includes compounds represented by general formulas (I) to (VI), which include [the specified element].

[0028] Another aspect of the present invention relates to a topical composition comprising at least one liquid crystal particle, at least one thickener, and water, as described above and below herein. [Brief explanation of the drawing]

[0029] [Figure 1] This figure shows the orthorhombic lateral packing of liquid crystal lipid particles. [Figure 2] This figure shows a transparent / flexible lipid film formed by the treatment of liquid crystal lipid particles. [Figure 3] This figure shows that a film formed by liquid crystal lipid particles has a liquid-repellent effect. [Figure 4]This figure shows that a film formed by liquid crystal lipid particles has an anti-adhesion effect. [Figure 5] This figure shows the increase in the moisturizing effect of a composition containing liquid crystal lipid particles, as measured by a corneometer. [Modes for carrying out the invention]

[0030] Before describing the compositions and formulations of the present invention, it should be understood that the present invention is not limited to such specific compositions and formulations, as the specific compositions and formulations described may naturally vary. It should also be understood that the scope of the present invention is limited only by the appended claims, and therefore the terms used herein are not intended to be restrictive.

[0031] Hereinafter, when a group is defined as including at least a certain number of embodiments, this is also intended to preferably include a group consisting only of these embodiments. Furthermore, terms such as “first,” “second,” “third,” or “a,” “b,” “c,” etc., in this description and claims are used to distinguish similar elements and are not necessarily used to describe a sequential or chronological order. Terms used in this way are interchangeable under appropriate circumstances, and it should be understood that the embodiments of the present invention described herein may be operated in an order other than that described or explained herein. Where terms such as “first,” “second,” “third,” or “(A),” “(B),” and “(C),” or “(a),” “(b),” “(c),” “(d),” “i,” “ii,” etc. relate to a method, use, or assay step, unless otherwise indicated in this application as expressly stated above or below, there may be no consistency in the time or time intervals between steps, i.e., steps may be performed simultaneously, or there may be time intervals of seconds, minutes, hours, days, weeks, months, or even years between such steps.

[0032] Furthermore, the ranges defined throughout this specification include terminal values; that is, the range 1 to 10 implies that both 1 and 10 are included within that range. To avoid misunderstanding, the applicant shall have rights to any equivalent under applicable law.

[0033] The following sections define different embodiments of the present invention in more detail. Each of these embodiments may be combined with any other embodiments or combinations of embodiments unless otherwise clearly indicated. In detail, any feature indicated as preferred or advantageous may be combined with any other features or combinations indicated as preferred or advantageous.

[0034] Throughout this specification, the indication "one embodiment" or "one embodiment" means that a particular feature, structure, or characteristic described in relation to an embodiment is included in at least one embodiment of the present invention. Therefore, occurrences of the phrase "in one embodiment" or "in one embodiment" in various parts throughout this specification do not necessarily all refer to the same embodiment, although they may refer to the same embodiment. Furthermore, certain features, structures, or characteristics may be combined in any preferred manner as will be apparent to those skilled in the art from this disclosure in one or more embodiments. Furthermore, some embodiments described herein include certain features but do not include other features included in other embodiments, while combinations of features from different embodiments are intended to form different embodiments, as will be understood to those skilled in the art, and are within the scope of the present invention. For example, in the appended claims, any of the claimed embodiments may be used in any combination.

[0035] "Topical application" means directly applying or spreading the composition onto the skin surface of a human or animal body, preferably the face, scalp, feet, limbs, or trunk.

[0036] The present invention relates to a method for reducing dust adhesion to the skin, which includes applying at least one type of liquid crystal lipid particle to the skin. Liquid crystal lipid particles are at least one compound of formula (I)

[0037] [ka] [In the formula, m is an integer between 10 and 24, and n is an integer between 1 and 25.] at least one compound of formula (II)

[0038] [ka] [In the formula, a is an integer in the range of 10 to 24.] at least one compound of formula (III)

[0039] [ka] [In the formula, x is an integer between 10 and 24, and y is an integer between 10 and 25.] at least one compound of formula (IV)

[0040] [ka] [In the formula, p is an integer in the range of 10 to 16.] at least one compound of formula (V)

[0041] [ka] [In the formula, A and B are each independently a hydrogen atom or an alkali Repayment It is a member of the group or an alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group. and at least one compound of formula (VI)

[0042] [ka] [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, alkah Repayment [It is a member of the group or an alkaline earth metal.] This includes compounds represented by general formulas (I) to (VI), which include [the specified element].

[0043] In one embodiment, the present invention relates to the use of at least one liquid crystal lipid particle to reduce the adhesion of dust to the skin, Liquid crystal lipid particles are at least one compound of formula (I)

[0044] [ka] [In the formula, m is an integer between 10 and 24, and n is an integer between 1 and 25.] at least one compound of formula (II)

[0045] [ka] [In the formula, a is an integer in the range of 10 to 24.] at least one compound of formula (III)

[0046] [ka] [In the formula, x is an integer between 10 and 24, and y is an integer between 10 and 25.] at least one compound of formula (IV)

[0047] [ka] [In the formula, p is an integer in the range of 10 to 16.] at least one compound of formula (V)

[0048] [ka] [In the formula, A and B are each independently a hydrogen atom or an alkali Repayment It is a member of the group or an alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group. and at least one compound of formula (VI)

[0049] [ka] [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, alkah Repayment [It is a member of the group or an alkaline earth metal.] This includes compounds represented by general formulas (I) to (VI), which include [the specified element].

[0050] In one embodiment of the present invention, the topical composition comprises at least one liquid crystal particle as defined above, at least one thickening agent, and water.

[0051] The liquid crystal lipid particles of the present invention are compounds represented by general formulas (I) to (IV).

[0052] [ka] [In the formula, m is an integer between 10 and 24, and n is an integer between 1 and 25.]

[0053] [ka] [In the formula, a is an integer in the range of 10 to 24.]

[0054] [ka] [In the formula, x is an integer between 10 and 24, and y is an integer between 10 and 25.] and

[0055]

Chem.

[0056] The liquid crystal particles of the present invention comprise at least one compound selected from the group consisting of compounds represented by general formulas (I) to (IV), and further at least one compound of general formula (V) or (VI)

[0057]

Chem.

[0058]

Chem.

[0059] In one embodiment of the present invention, the liquid crystal lipid particles comprise at least one compound represented by general formula (I), and at least one compound selected from the group consisting of compounds represented by general formulas (II), (III) and (IV).

[0060] In one embodiment of the present invention, the liquid crystal lipid particles comprise at least one compound represented by general formula (I), and at least one compound selected from the group consisting of compounds represented by general formulas (II), (III), (IV), (V) and (VI).

[0061] In yet another embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (II), and at least one compound selected from the group consisting of compounds represented by general formulas (I), (III), and (IV).

[0062] In yet another embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (II), and at least one compound selected from the group consisting of compounds represented by general formulas (I), (III), (IV), (V), and (VI).

[0063] In yet another embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (III), and at least one compound selected from the group consisting of compounds represented by general formulas (I), (II), and (IV).

[0064] In yet another embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (III), and at least one compound selected from the group consisting of compounds represented by general formulas (I), (II), (IV), (V), and (VI).

[0065] In yet another embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (IV), and at least one compound selected from the group consisting of compounds represented by general formulas (I), (II), (III), (V), and (VI).

[0066] In a further embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (I), at least one compound represented by general formula (II), at least one compound represented by general formula (III), and at least one compound represented by general formula (IV).

[0067] In another embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (I), at least one compound represented by general formula (II), at least one compound represented by general formula (III), at least one compound represented by general formula (IV), and at least one compound represented by general formula (V).

[0068] In a further embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (I), at least one compound represented by general formula (II), at least one compound represented by general formula (III), at least one compound represented by general formula (IV), and at least one compound represented by general formula (VI).

[0069] In a further embodiment of the present invention, the liquid crystal lipid particles include at least one compound represented by general formula (I), at least one compound represented by general formula (II), at least one compound represented by general formula (III), at least one compound represented by general formula (IV), at least one compound represented by general formula (VI), at least one compound represented by general formula (V), and at least one compound represented by general formula (VI).

[0070] In one embodiment of the present invention, the liquid crystal lipid particles are at least one compound represented by general formula (I).

[0071] [ka] [In the formula, m is an integer between 10 and 24, and n is an integer between 1 and 25.] Includes.

[0072] In one embodiment of the present invention, at least one compound of general formula (I) is selected from the group consisting of ceteareth, polyoxyethylene stearyl ether, and polyoxyethylene cetyl ether.

[0073] In one embodiment of the present invention, at least one compound of general formula (I) is selected from the group consisting of ceteareth-12, ceteareth-12, and ceteareth-30.

[0074] In the most preferred embodiment of the present invention, at least one compound of general formula (I) is selected from the group consisting of ceteareth-12, ceteareth-12.

[0075] In one embodiment of the present invention, at least one compound of general formula (II)

[0076] [ka] In this case, a is an integer in the range of 10 to 24.

[0077] In one embodiment of the present invention, at least one compound of general formula (II) is selected from the group consisting of glyceryl stearate, glyceryl laurate, glyceryl palmitate, glyceryl caprylate, and glyceryl myristate.

[0078] In a preferred embodiment of the present invention, at least one compound of general formula (II) is glyceryl stearate.

[0079] In one embodiment of the present invention, at least one compound of general formula (III)

[0080] [ka] In this equation, x is an integer between 10 and 24 (inclusive), and y is an integer between 10 and 25 (inclusive).

[0081] In one embodiment of the present invention, at least one compound of general formula (III) is myristyl myristate, myristyl palmitate, myristyl stearate, myristyl isostearate, myristyl oleate, myristyl behenate, myristyl erucate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, stearin Selected from the group consisting of isostearyl acid, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate, and erucate.

[0082] In further embodiments of the present invention, at least one compound of general formula (III) is selected from the group consisting of cetyl palmitate, myristyl myristate, tetradecyl tetradecanoate, and behenyl behenate.

[0083] In a preferred embodiment of the present invention, at least one compound of general formula (III) is selected from the group consisting of cetyl palmitate and myristyl myristate.

[0084] In one embodiment of the present invention, at least one compound of general formula (IV)

[0085] [ka] In this case, p is an integer in the range of 10 to 16.

[0086] In yet another embodiment of the present invention, at least one compound of general formula (IV) is selected from the group consisting of lauryl alcohol, tridecyl alcohol, myristyl alcohol, pentadecyl alcohol, cetyl alcohol, palmitrail alcohol, heptadecyl alcohol, and stearyl alcohol or mixtures thereof.

[0087] In a preferred embodiment of the present invention, at least one compound of general formula (IV) is selected from the group consisting of lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, or mixtures thereof.

[0088] In the most preferred embodiment of the present invention, at least one compound of general formula (IV) is a mixture of cetyl alcohol and stearyl alcohol.

[0089] In one embodiment of the present invention, at least one compound of general formula (V)

[0090] [ka] In this, A and B are each independently hydrogen atoms or alkalis Repayment A C genus or alkaline earth metal, where R is a linear or branched, saturated or unsaturated C. 10 ~C 20 It is an aliphatic group.

[0091] In one embodiment of the present invention, in at least one compound of general formula (V), A and B are each independently alkaline earth metals, and R is a linear or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group.

[0092] In further embodiments of the present invention, in at least one compound of general formula (V), R is n-decyl, iso-decyl, n-undecyl, iso-undecyl, n-dodecyl, iso-dodecyl, n-tridecyl, iso-tridecyl, n-tetradecyl, iso-tetradecyl, n-pentadecyl, iso-pentadecyl, n-hexadecyl, iso-hexadecyl, n-heptadecyl, iso-heptadecyl, n-octadecyl, iso-octadecyl, and n-octadecenyl.

[0093] In a further embodiment of the present invention, at least one compound of general formula (V) is disodium C 10 ~C 18 It is an alkyl sulfosuccinate.

[0094] In a preferred embodiment of the present invention, at least one compound of general formula (V) is disodium C 12 ~C 18 It is an alkyl sulfosuccinate.

[0095] In the most preferred embodiment of the present invention, at least one compound of general formula (V) is C 16 ~C 18 It is an alkyl sulfosuccinate.

[0096] In one embodiment of the present invention, at least one compound of general formula (VI)

[0097] [ka] In this, r is an integer in the range of 9 to 18, and M is a hydrogen atom, an alkali Repayment It is a member of the genus or an alkaline earth metal.

[0098] In one embodiment of the present invention, in at least one compound of general formula (VI), M is sodium or potassium, and r is an integer in the range of 9 to 18.

[0099] In one embodiment of the present invention, at least one compound of general formula (VI) is selected from the group consisting of sodium stearoyl glutamate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium myristoyl glutamate, potassium cocoyl glutamate, potassium lauroyl glutamate, and combinations thereof.

[0100] In one embodiment of the present invention, at least one compound of general formula (VI) is selected from the group consisting of sodium lauroyl glutamate, sodium cocoyl glutamate, sodium myristoyl glutamate, and sodium stearoyl glutamate.

[0101] In one embodiment of the present invention, the liquid crystal lipid particles include ceteareth, glyceryl stearate, cetyl palmitate, cetyl alcohol, and stearyl alcohol.

[0102] In yet another embodiment of the present invention, the liquid crystal lipid particles include ceteareth, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, and stearyl alcohol.

[0103] In a further embodiment of the present invention, the liquid crystal lipid particles include ceteareth, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 10 ~C 18 It includes compounds selected from the group consisting of alkyl sulfosuccinates and sodium stearoyl glutamate.

[0104] In preferred embodiments of the present invention, the liquid crystal lipid particles are ceteareth-12, ceteareth-12, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 16 ~C 18 It contains compounds selected from the group consisting of alkyl sulfosuccinates and sodium lauroyl glutamate.

[0105] In another preferred embodiment of the present invention, the liquid crystal lipid particles are ceteareth-12, ceteareth-12, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 12 ~C 14 It contains compounds selected from the group consisting of alkyl sulfosuccinates and sodium lauroyl glutamate.

[0106] In yet another preferred embodiment of the present invention, the liquid crystal lipid particles are ceteareth-12, ceteareth-12, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 12 ~C 14 It includes compounds selected from the group consisting of alkyl sulfosuccinates and sodium stearoyl glutamate.

[0107] In the most preferred embodiment of the present invention, the liquid crystal lipid particles are ceteareth-12, ceteareth-12, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 16 ~C 18 It includes compounds selected from the group consisting of alkyl sulfosuccinates and sodium stearoyl glutamate.

[0108] In one embodiment of the present invention, the liquid crystal lipid particles have an average particle size of 20 nm to 500 nm, determined using dynamic light scattering with a Malvern DLS ZS90.

[0109] In one embodiment of the present invention, the liquid crystal lipid particles have an average particle size of 20 nm to 300 nm, determined using dynamic light scattering with a Malvern DLS ZS90.

[0110] In one embodiment of the present invention, the liquid crystal lipid particles have an average particle size of 20 nm to 150 nm, determined using dynamic light scattering with a Malvern DLS ZS90.

[0111] In one embodiment of the present invention, the liquid crystal lipid particles have an average particle size of 20 nm, 30 nm, 40 nm, 50 nm, 60 nm, 70 nm, 80 nm, 90 nm, 100 nm, 110 nm, 120 nm, 130 nm, 140 nm, or 150 nm, as determined using dynamic light scattering with Malvern DLS ZS90.

[0112] The zeta potential of liquid crystal lipid particles is a measure of the charge on the particle's surface and a measure of the lipid particle's stability. A higher zeta potential indicates greater stability.

[0113] In one embodiment of the present invention, the liquid crystal lipid particles have a zeta potential greater than 20 mV when measured at 40°C.

[0114] In one embodiment of the present invention, the liquid crystal lipid particles have a zeta potential greater than 30 mV when measured at 40°C.

[0115] In one embodiment of the present invention, liquid crystal lipid particles are prepared by using the phase inversion temperature method.

[0116] In further embodiments of the present invention, liquid crystal lipid particles are prepared using the phase inversion temperature method disclosed by reference herein in DJ Mitchell et al., Phase behavior of polyoxyethylene surfactants with water. Mesophase structures and partial miscibility (cloud points), J. Chem. Soc. Farayday Trans., 79, pp. 975-1000 (1983).

[0117] In one embodiment of the present invention, the liquid crystal lipid particles have orthorhombic lateral packing.

[0118] In one embodiment of the present invention, liquid crystal lipid particles are included in a topical composition for application to the skin.

[0119] In one embodiment of the present invention, liquid crystal lipid particles form a base in any topical composition for application to the skin.

[0120] In one embodiment of the present invention, at least one type of liquid crystal lipid particle is present in an amount ranging from 1% to 30% by weight based on the total weight of the topical composition.

[0121] In a further embodiment of the present invention, at least one liquid crystal lipid particle is present in an amount ranging from 1% to 25% by weight based on the total weight of the topical composition.

[0122] In a preferred embodiment of the present invention, at least one liquid crystal lipid particle is present in an amount ranging from 1% to 20% by weight based on the total weight of the topical composition.

[0123] In the most preferred embodiment of the present invention, at least one liquid crystal lipid particle is present in an amount ranging from 1% to 15% by weight based on the total weight of the topical composition.

[0124] In one embodiment of the present invention, the topical composition exists in the form of a cream, foam, lotion, gel, paste, spray, patch, spray patch, mousse, or ointment.

[0125] In one embodiment of the present invention, the topical composition further comprises at least one auxiliary agent selected from the group consisting of anti-wrinkle activators, anti-acne activators, emulsifiers, antioxidants, skin emollients, self-tanning activators, whitening agents, sunscreens, UV absorbers, thickeners, wetting agents, abrasives, absorbents, fragrances, buffers, milky agents, colorants, preservatives, fillers, pH adjusters, and solvents.

[0126] In one embodiment of the present invention, the activator is selected from the group consisting of anti-wrinkle agents such as retinol, hyaluronic acid, ceramide, niacinamide, vitamin E, and alpha hydroxy acids, and anti-acne agents such as clindamycin, benzamycin, benzoyl peroxide, and isotretinoin.

[0127] In one embodiment of the present invention, the whitening agent is selected from the group consisting of tretinoin, hydroquinone, resorcinol, arbutin, kojic acid, azelaic acid, vitamin C, glutathione, and alpha hydroxy acids.

[0128] In one embodiment of the present invention, the ultraviolet absorber or sunscreen is, for example: p-aminobenzoic acid, its salts and derivatives (ethyl, isobutyl, glyceryl esters; p-dimethylaminobenzoic acid, diethylaminohydroxybenzoyl hexyl benzoate); anthranilic acid esters (i.e., o-aminobenzoic acid esters; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl and cyclohexenyl esters); salicylic acid esters (amyl, phenyl, benzyl, menthyl, glyceryl and dipropylene glycosides) Calcium esters); Cinnamic acid derivatives (menthyl and benzyl esters, butyl cinnamoylpyruvate); Dihydroxycinnamic acid derivatives (umbelliferone, methylumbelliferone, methylacetoumbelliferone); Trihydroxycinnamic acid derivatives (esculetin, methylesculetin, daphnetin and glucoside, esculin and daphnin); Hydrocarbons (diphenylbutadiene, stilbene); Dibenzalacetone and benzalacetophenone; Naphthol sulfonates (sodium salt of 2-naphthol-3,6-disulfonic acid and 2 -Sodium salt of naphthol-6,8-disulfonic acid; dihydroxy-naphthoic acid and its salts; o- and p-hydroxybiphenyl disulfonates; coumarin derivatives (7-hydroxy, 7-methyl, 3-phenyl); diazoles (2-acetyl-3-bromoindazole, phenylbenzoxazole, methylnaphthoxazole, various arylbenzothiazoles); quinine salts (bisulfate, sulfate, chloride, oleate and tannate); hydroxy or methoxy-substituted benzophenones; uric acid and pyrouric acid; tannic acid and its derivatives Selected from the group of suitable sunscreens comprising: (e.g., hexaethyl ether); (butylcarbonol)(6-propylpiperonyl) ether; benzophenone (oxybenzene, surisobenzone, dioxybenzone, benzoresorcinol, 2,2',4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, octabenzone); 4-isopropyldibenzoylmethane; butylmethoxydibenzoylmethane; etocrylene; and 4-isopropyl-dibenzoylmethane.

[0129] In preferred embodiments of the present invention, the ultraviolet absorber or sunscreen is 2-ethylhexyl-p-methoxycinnamate, 4,4'-t-butylmethoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyldimethyl-p-aminobenzoic acid, digalloyl trioleate, 2,2-dihydroxy-4-methoxybenzophenone, ethyl-4(bis(hydroxypropyl))aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-ethyl The following are selected from the group consisting of hexyl salicylate, glyceryl-p-aminobenzoate, 3,3,5-trimethylcyclohexyl salicylate, methyl anthranilate, p-dimethylaminobenzoic acid or aminobenzoate, 2-ethylhexyl-p-dimethylaminobenzoate, 2-phenylbenzimidazole-5-sulfonic acid, 2-(p-dimethylaminophenyl)-5-sulfonicbenzoxazoic acid, methylenebis-benzotriazolyltetramethylbutylphenol, and mixtures thereof.

[0130] In one embodiment of the present invention, the thickener is selected from the group consisting of nonionic thickeners, anionic thickeners, or polymeric thickeners containing mixtures thereof. Suitable nonionic thickeners include polyacrylamide polymers, crosslinked poly(N-vinylpyrrolidone), polysaccharides, natural or synthetic gums or polysaccharides, polyvinylpyrrolidone, and polyvinyl alcohol. Suitable anionic thickeners include acrylic acid / ethyl acrylate copolymers, carboxyvinyl polymers, and crosslinked copolymers of alkyl vinyl ethers and maleic anhydride.

[0131] In one embodiment of the present invention, the thickener is selected from the group consisting of polysaccharides including cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethylethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate and mixtures thereof, natural gums such as acacia, agar, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gelan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silicic acid, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum and mixtures thereof.

[0132] In one embodiment of the present invention, the wetting agent is selected from the group consisting of sodium 2-pyrrolidone-5-carboxylate (NaPCA), guanidine, glycolic acid and glycolates (e.g., ammonium and quaternary alkylammonium), lactic acid and lactates (e.g., ammonium and quaternary alkylammonium), aloe vera in any variety of forms (e.g., aloe vera gel), hyaluronic acid and its derivatives (e.g., salt derivatives, e.g., sodium hyaluronate), lactamide monoethanolamine, acetamide monoethanolamine, urea, panthenol and its derivatives, and mixtures thereof.

[0133] In one embodiment of the present invention, the buffering agent is selected from the group consisting of lactic acid, lactate, gluconic acid, glucono-delta-lactone, sodium gluconate and potassium gluconate, trisodium citrate, tripotassium citrate, sodium lactate and potassium lactate.

[0134] In one embodiment of the present invention, the solvent is selected from the group consisting of glycerin, diglycerin, triglycerin, polyglycerin, polypropylene glycol, polyethylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, hexylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, ethylene glycol monoalkyl ether, diethylene glycol monoalkyl ether, glucose, maltose, sucrose, lactose, xylitol, xylitol, sorbitol, mannitol, maltitol, malbit, panthenol, pentaerythritol, and polyhydric alcohols including hyaluronic acid and its salts, water, ethanol, and isopropanol.

[0135] In one embodiment of the present invention, the solvent is selected from the group consisting of glycerin, water, and ethanol.

[0136] In one embodiment of the present invention, the preservative is selected from the group consisting of benzalkonium chloride, benzethonium chloride, benzyl alcohol, caprylyl glycol, chlorphenesin, 2,2'-dithiobis(N-methylbenzamide), diazolidinyl urea, ethylenediaminetetraacetic acid, ethylparaben, imidazolidinyl urea, methylparaben, phenoxyethanol, linoleamidopropyl PG-diammonium chloride phosphate, cocamidopropyl PG-diammonium chloride phosphate, propylparaben, cis-1-(3-chloroallyl)-3,5,7-triaza-1-azonia adamantan chloride, dehydroacetic acid or a salt thereof, benzoic acid or a salt thereof, sodium hydroxymethylglycinate, and zinc pyrithione.

[0137] In one embodiment of the present invention, liquid crystal lipid particles are included in a topical composition further comprising a sunscreen, an ultraviolet absorber, a thickener, and a solvent.

[0138] In a preferred embodiment of the present invention, the liquid crystal lipid particles are contained in a topical composition further comprising diethylaminohydroxybenzoyl hexyl benzoate, ethylhexyl methoxycinnamate, acrylate / beheneth-25 methylacrylate copolymer, methylenebis-benzotriazolyltetramethylbutylphenol, decyl glucoside, propylene glycol, xanthan gum, ethanol, water, and butylene glycol.

[0139] The effects of this composition in restoring or maintaining the integrity of the outer layer of the skin barrier can be applied to many different uses. For example, this composition can be used to treat any condition caused by an incomplete or defective barrier. In this regard, this composition can be used to improve the long-term moisture retention of the skin, or in the prevention or treatment of general dry skin conditions, or, for example, habitual exposure to detergents, soaps and hot water; seasonal exposure to harsh climatic conditions, such as cold, wind and / or sun; specific dry skin conditions resulting from occupational exposure to harsh chemicals or other drying or damaging factors; or pathological conditions, such as eczematous dermatitis, psoriasis, ichthyosis, xerosis, etc.

[0140] It is well known that dry skin is generally associated with aging (both natural and photoaging), and this composition can be used to prevent further damage to aged skin, or to treat and / or restore existing damage, including the appearance of fine lines and wrinkles, which are often associated with dry skin and thinning of the stratum corneum that occurs with age. This composition can also be used to treat defective skin barriers, such as those that occur on the soles of the feet and palms of the hands, where the stratum corneum is very thick but the lipid barrier is poor. In addition, defective skin barriers often occur in association with burns, trauma, blisters, congestive ulcers and pressure ulcers, and such injuries can be expected to benefit from the application of this composition.

[0141] The compositions of the present invention can be used to reduce the skin's response to irritants and sensitizers. A significant portion of the population has sensitive skin, in that it frequently experiences stinging or painful responses to various elements to which the skin may be exposed through makeup or skincare products, environmental irritants such as smoking or pollution, or occupational exposure to chemicals. In addition, even normal skin can react to exposure to known irritants, such as acids.

[0142] Since it is well known that the stratum corneum and lipids constitute the first line of defense against irritants by providing a physical barrier against the penetration of such substances into lower layers of the skin, the application of the compositions of the present invention can reduce the reactivity of the skin of both normal and sensitive individuals to irritants and sensitizers by increasing the integrity of the barrier. In one embodiment, for example, the compositions can be used to reduce the skin's reaction to irritation caused by therapeutic acids, such as alpha- and beta-hydroxy acids, retinoic acid, etc., or to reduce irritation caused by insect bites, or to alleviate irritation experienced in contact dermatitis.

[0143] The compositions of the present invention are used in a manner suitable for the intended end use of the product. For example, in the treatment of intermittent dry skin resulting from exposure to climate or other temporary conditions, or in the treatment of intermittent skin irritation, the compositions can be used as needed until the condition subsides. When used to treat more permanent conditions, such as those associated with a defective or incomplete lipid barrier, particularly sensitive skin, dry skin associated with all types of aging, or wrinkles or fine lines associated with age-related thinning of the stratum corneum, the compositions are preferably applied chronically to prevent recurrence of the condition.

[0144] In one embodiment, the composition of the present invention is approximately 0.1 mg / 1 cm³. 2 Skin: ~2mg / 1cm 2Depending on the amount of skin, it can be applied approximately once a week to approximately four or five times a day, preferably approximately three times a week to approximately three times a day, and most preferably approximately once or twice a day.

[0145] Furthermore, the composition of the present invention can be applied for a longer duration, preferably at least about one month, from about three months to about 20 years, more preferably from about six months to about 10 years, and even more preferably from about one year to about five years, thereby providing treatment or prevention of the condition in question.

[0146] advantage: 1. Liquid crystal lipid particles have a defined shape, thereby mimicking the structure of skin. 2. The liquid crystal lipid particles contained in the composition form a flexible film on the skin, so the skin can be protected from contaminants and provide a moisturizing effect to the skin. 3. The liquid crystal lipid particle composition is stable under various temperature conditions.

[0147] Embodiment 1. A method for reducing the adhesion of dust to the skin, comprising applying at least one type of liquid crystal lipid particle to the skin, Liquid crystal lipid particles, at least one compound of formula (I)

[0148] [ka] [In the formula, m is an integer between 10 and 24, and n is an integer between 1 and 25.] at least one compound of formula (II)

[0149] [ka] [In the formula, a is an integer in the range of 10 to 24.] at least one compound of formula (III)

[0150] [ka] [In the formula, x is an integer between 10 and 24, and y is an integer between 10 and 25.] at least one compound of formula (IV)

[0151] [ka] [In the formula, p is an integer in the range of 10 to 16.] at least one compound of formula (V)

[0152] [ka] [In the formula, A and B are each independently a hydrogen atom or an alkali Repayment It is a member of the group or an alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group. and at least one compound of formula (VI)

[0153] [ka] [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, alkah Repayment [It is a member of the group or an alkaline earth metal.] A method comprising compounds represented by general formulas (I) to (VI), including the above. 2. Use of at least one liquid crystal lipid particle to reduce the adhesion of dust to the skin, wherein the liquid crystal lipid particle is at least one compound of formula (I)

[0154] [ka] [In the formula, m is an integer between 10 and 24, and n is an integer between 1 and 25.] at least one compound of formula (II)

[0155] [ka] [In the formula, a is an integer in the range of 10 to 24.] at least one compound of formula (III)

[0156] [ka] [In the formula, x is an integer between 10 and 24, and y is an integer between 10 and 25.] at least one compound of formula (IV)

[0157] [ka] [In the formula, p is an integer in the range of 10 to 16.] at least one compound of formula (V)

[0158] [ka] [In the formula, A and B are each independently a hydrogen atom or an alkali Repayment It is a member of the group or an alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group. and at least one compound of formula (VI)

[0159] [ka] [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, alkah Repayment [It is a member of the group or an alkaline earth metal.] Includes compounds represented by general formulas (I) to (VI), including the above. 3. The method or use according to Embodiment 1 or 2, wherein the liquid crystal lipid particles have a lamellar structure with orthorhombic lateral packing. 4. The method or use according to Embodiment 1 or 2, wherein the liquid crystal lipid particles have an average particle size in the range of 20 nm to 300 nm, as determined by dynamic light scattering using a Malvern DLS ZS90. 5. The method or use according to Embodiment 1 or 2, wherein the liquid crystal lipid particles have a zeta potential greater than 20 mV. 6. The method or use according to Embodiments 1 to 5, wherein at least one compound of general formula (I) is selected from the group consisting of ceteareth, polyoxyethylene stearyl ether and polyoxyethylene cetyl ether. 7. The method or use according to Embodiments 1 to 6, wherein at least one compound of general formula (II) is selected from the group consisting of glyceryl stearate, glyceryl laurate, and glyceryl palmitate. 8. The method or use according to Embodiments 1 to 7, wherein at least one compound of general formula (III) is selected from the group consisting of cetyl palmitate, myristyl myristate, tetradecyl tetradecanoate, and behenyl behenate. 9. The method or use according to Embodiments 1 to 8, wherein at least one compound of general formula (IV) is selected from the group consisting of lauryl alcohol, tridecyl alcohol, myristyl alcohol, pentadecyl alcohol, cetyl alcohol, palmitrail alcohol, heptadecyl alcohol, stearyl alcohol, or mixtures thereof. 10. At least one compound of general formula (V) is disodium C 10 ~C 18 The method or use described in Embodiments 1 to 9, wherein the alkyl sulfosuccinate is used. 11. The method or use according to Embodiments 1 to 10, wherein at least one compound of general formula (VI) is selected from the group consisting of sodium lauroyl glutamate, sodium cocoyl glutamate, sodium myristoyl glutamate, and sodium stearoyl glutamate. 12. The method or use according to any one of Embodiments 1 to 11, wherein the liquid crystal lipid particles comprise ceteareth, glyceryl stearate, cetyl palmitate, cetyl alcohol, and stearyl alcohol. 13. The use according to any one of Embodiments 1 to 11, wherein the liquid crystal lipid particles comprise ceteareth, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, and stearyl alcohol. 14. Liquid crystal lipid particles include ceteareth, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 10 ~C 18 The use according to any one of Embodiments 1 to 11, comprising a compound selected from the group consisting of alkyl sulfosuccinates and sodium stearoyl glutamate. 15. Liquid crystal lipid particles include ceteareth-12, ceteareth-12, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 16 ~C 18 The use according to any one of Embodiments 1 to 11, comprising a compound selected from the group consisting of alkyl sulfosuccinates and sodium stearoyl glutamate. 16. At least one liquid crystal particle described in any one of Embodiments 1 to 15, At least one thickening agent, A topical composition containing water. 17. The topical composition according to Embodiment 16, wherein at least one thickening agent is selected from the group consisting of xanthan gum, succinoglycan, gellan gum, pectin, alginate, starch, guar, acrylate, acrylate copolymer, carbomer, and associative thickener. 18. The topical composition according to Embodiment 16 or 17, wherein at least one liquid crystal lipid particle is present in an amount ranging from 1% by weight to 30% by weight based on the total weight of the topical composition. 19. The topical composition according to any one of embodiments 16 to 18, wherein at least one thickening agent is present in an amount ranging from 0.1% by weight to 5% by weight based on the total weight of the topical composition. 20. The topical composition according to any one of embodiments 16 to 19, wherein water is present in an amount ranging from 5% by weight to 80% by weight based on the total weight of the topical composition. 21. A topical composition according to any one of Embodiments 16 to 20, further comprising at least one auxiliary agent selected from the group consisting of anti-wrinkle agents, anti-acne agents, emulsifiers, antioxidants, emollients, self-tanning agents, whitening agents, sunscreens, humectants, abrasives, absorbents, fragrances, buffers, milking agents, colorants, preservatives, fillers, and pH adjusters. 22. A topical composition according to any one of Embodiments 16 to 21, which is a skincare composition. 23. A topical composition according to any one of Embodiments 12 to 22, which exists in the form of a cream, foam, lotion, gel, paste, or ointment. 24. A method for reducing dust adhesion to the skin, comprising applying a topical composition described in any one of Embodiments 16 to 23 to the skin. [Examples]

[0160] Examples are provided below to illustrate methods and results based on the subject matter of this disclosure. These examples are not intended to encompass all aspects of the subject matter disclosed herein, but rather to illustrate representative methods, compositions, and results. These examples are not intended to exclude equivalents and modifications of the present invention that would be obvious to those skilled in the art.

[0161] material: Ingredients from BASF: Emulgade(registered trademark) SE-PF is an emulsifying agent consisting of glyceryl stearate, ceteareth-20, ceteareth-12, cetyl alcohol, and cetyl palmitate. Eumulgin(registered trademark) B1 is ceteareth-12 (cetyl stearyl alcohol with 12 mol of EO), and is a nonionic emulsifier. Cetiol(registered trademark)MM is myristyl myristate, a skin emollient. Eumulgin® Prisma is a disodium C16-C18 alkyl sulfosuccinate and is an anionic emulsifier. Eumulgin(registered trademark) SG is sodium stearoyl glutamate, an anionic emulsifier. Uvinul(registered trademark) A Plus is diethylamino hydroxybenzoyl hexyl benzoate, which is an ultraviolet absorber. Uvinul(registered trademark) MC 80 is ethylhexyl methoxycinnamate and is an ultraviolet absorber. Tinovis® GTC is an acrylate / beheneth-25 methylacrylate copolymer and is used as a thickener or viscosity modifier. Rhenocare® XGN is a xanthan gum, which is a viscosity modifier or thickener. Tinisorb® M is a UV filter composed of methylenebis-benzotriazolyltetramethylbutylphenol, water, decyl glucoside, propylene glycol, and xanthan gum. From Clariant Phenonip® is phenoxyethanol (and) methylparaben (and) ethylparaben (and) propylparaben (and) butylparaben (and) isobutylparaben, and is used as a broad-spectrum antimicrobial agent or preservative.

[0162] method: Particle size measurement: The particle size of liquid crystal lipid particles was measured using a Malvern DLS ZS90. Zeta potential measurement: The zeta potential was measured using Zetasizer nano ZS90 (Malvern).

[0163] [Example 1] Base composition of liquid crystal lipid particles

[0164] [Table 1]

[0165] Manufacturing process: Phase inversion temperature emulsification method 1) The raw materials of Part A and Part B were separately heated to 80°C. 2) Part A was added to Part B and mixed using a homogenizer until it became homogeneous to form the base. 3) Part C was mixed into the base from Step 2. 4) The base formed in Step 4 was cooled to room temperature in an ice bath. 5) Part D was added to the base and mixed using a homogenizer until it became homogeneous.

[0166] Results

[0167] [Table 2]

[0168] [Example 2]

[0169] [Table 3]

[0170] Manufacturing process: 1) The raw materials of Part A and Part B were separately heated to 80°C. 2) Part A was added to Part B while homogenizing and mixed until it became homogeneous. 3) Part C was mixed with the mixture of Part A and B and cooled to 45°C. 4) Part D was added to the mixture from Step 3 and mixed using a homogenizer until it became homogeneous. Then it was cooled to room temperature.

[0171] [Example 3] Dust-resistant performance - Test protocol 1) 4g of each composition based on Example 2T1 to 2T3 was coated onto a PMMA board. 2) Another 2g of the composition was applied to the board to ensure a uniform distribution of the composition on the board. 3) The board was placed in a 38°C oven overnight. 4) The board was placed upside down on a tray on which the dust had been weighed, and gently shaken for 30 seconds. 5) The board was turned upright again and the dish was weighed with respect to the sand.

[0172] result

[0173] [Table 4] In Example 3T2, the dust adhesion is lower, demonstrating the superior performance of compositions containing liquid crystal lipid particles as a base.

[0174] Referring to Figures 3 and 4, the reduction in dust adhesion to the skin surface after application of a composition containing liquid crystal lipid particles is shown.

[0175] [Example 4] Test the moisturizing effect.

[0176] [Table 5]

[0177] Manufacturing process 1) Dissolve Part A at 80°C. 2) Cool the base to room temperature, then add part B to the base. Mix until homogeneous.

[0178] Results: When measured with a corneometer, composition Example 4T5 showed a three-fold increase in moisturizing effect compared to Example 4T4. Figure 5 shows the results for Example 4T4.

Claims

1. A method for reducing the adhesion of dust to the skin, comprising applying to the skin a composition comprising at least one liquid crystal lipid particle contained in a solvent consisting of water and glycerin, Liquid crystal lipid particles, - At least one compound of formula (I) 【Chemistry 1】 [In the formula, m is an integer in the range of 10 to 24, and n is an integer in the range of 1 to 25] - At least one compound of formula (II) 【Chemistry 2】 [In the formula, a is an integer in the range of 10 to 24] - At least one compound of formula (III) 【Transformation 3】 [In the formula, x is an integer in the range of 10 to 24, and y is an integer in the range of 10 to 25] - At least one compound of formula (IV) 【Chemistry 4】 [In the formula, p is an integer in the range of 10 to 16] Includes, - At least one compound of formula (V) 【Transformation 5】 [In the formula, A and B are each independently a hydrogen atom or an alkali metal or alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group, or - At least one compound of formula (VI) 【Transformation 6】 [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, an alkali metal, or an alkaline earth metal.] It further includes, Here, liquid crystal lipid particles are particles having an average particle size in the range of 20 nm to 300 nm, determined by dynamic light scattering using Malvern DLS ZS90.

2. The use of a composition comprising at least one liquid crystal lipid particle contained in a solvent consisting of water and glycerin, for reducing the adhesion of dust to the skin, Liquid crystal lipid particles, - At least one compound of formula (I) 【Transformation 7】 [In the formula, m is an integer in the range of 10 to 24, and n is an integer in the range of 1 to 25] - At least one compound of formula (II) 【Transformation 8】 [In the formula, a is an integer in the range of 10 to 24] - At least one compound of formula (III) 【Chemistry 9】 [In the formula, x is an integer in the range of 10 to 24, and y is an integer in the range of 10 to 25] - At least one compound of formula (IV) 【Chemistry 10】 [In the formula, p is an integer in the range of 10 to 16] Includes, - At least one compound of formula (V) 【Chemistry 11】 [In the formula, A and B are each independently a hydrogen atom or an alkali metal or alkaline earth metal, R is a straight-chain or branched, saturated or unsaturated C 10 ~C 20 It is an aliphatic group, or, - At least one compound of formula (VI) 【Chemistry 12】 [In the formula, r is an integer in the range of 9 to 18, and M is a hydrogen atom, an alkali metal, or an alkaline earth metal.] It further includes, Here, liquid crystal lipid particles are defined as particles with an average particle size in the range of 20 nm to 300 nm, determined by dynamic light scattering using a Malvern DLS ZS90.

3. The method or use according to claim 1 or 2, wherein the liquid crystal lipid particles have a zeta potential greater than 20 mV.

4. The method or use according to any one of claims 1 to 3, wherein at least one compound of general formula (I) is selected from the group consisting of ceteareth, polyoxyethylene stearyl ether and polyoxyethylene cetyl ether.

5. The method or use according to any one of claims 1 to 4, wherein at least one compound of general formula (II) is selected from the group consisting of glyceryl stearate, glyceryl laurate, and glyceryl palmitate.

6. The method or use according to any one of claims 1 to 5, wherein at least one compound of general formula (III) is selected from the group consisting of cetyl palmitate, myristyl myristate, tetradecyl tetradecanoate, and behenyl behenate.

7. The method or use according to any one of claims 1 to 6, wherein at least one compound of general formula (IV) is selected from the group consisting of lauryl alcohol, tridecyl alcohol, myristyl alcohol, pentadecyl alcohol, cetyl alcohol, palmitrail alcohol, heptadecyl alcohol, stearyl alcohol, or mixtures thereof.

8. At least one compound of general formula (V) is disodium C 10 ~C 18 The method or use according to any one of claims 1 to 7, wherein the alkyl sulfosuccinate is used.

9. The method or use according to any one of claims 1 to 8, wherein at least one compound of general formula (VI) is selected from the group consisting of sodium lauroyl glutamate, sodium cocoyl glutamate, sodium myristoyl glutamate, and sodium stearoyl glutamate.

10. The method or use according to any one of claims 1 to 9, wherein the liquid crystal lipid particles comprise ceteareth, glyceryl stearate, cetyl palmitate, cetyl alcohol, and stearyl alcohol.

11. The use according to any one of claims 1 to 9, wherein the liquid crystal lipid particles comprise ceteareth, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, and stearyl alcohol.

12. The liquid crystal lipid particles are ceteareth, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 10 ~C 18 The use according to any one of claims 1 to 9, comprising a compound selected from the group consisting of alkyl sulfosuccinate and sodium stearoyl glutamate.

13. The use according to any one of claims 1 to 9, wherein the liquid crystal lipid particles contain a compound selected from the group consisting of cetearyl-20, cetearyl-12, glyceryl stearate, cetyl palmitate, myristyl myristate, cetyl alcohol, stearyl alcohol, and disodium C 16 ~C 18 -alkyl sulfosuccinate and sodium stearoyl glutamate.

14. At least one liquid crystal lipid particle according to any one of claims 1 to 13, At least one thickening agent and A topical composition containing water.

15. The topical composition according to claim 14, wherein at least one thickening agent is selected from the group consisting of xanthan gum, succinoglycan, gellan gum, pectin, alginate, starch, guar, acrylate, acrylate copolymer, carbomer, and associative thickener.

16. The topical composition according to claim 14 or 15, wherein at least one type of liquid crystal lipid particle is present in an amount ranging from 1% by weight to 30% by weight based on the total weight of the topical composition.

17. The topical composition according to any one of claims 14 to 16, wherein at least one thickening agent is present in an amount ranging from 0.1% by weight to 5% by weight based on the total weight of the topical composition.

18. The topical composition according to any one of claims 14 to 17, wherein water is present in an amount ranging from 5% by weight to 80% by weight based on the total weight of the topical composition.

19. A topical composition according to any one of claims 14 to 18, further comprising at least one auxiliary agent selected from the group consisting of anti-wrinkle agents, anti-acne agents, emulsifiers, antioxidants, emollients, self-tanning agents, whitening agents, sunscreens, humectants, abrasives, absorbents, fragrances, buffers, milking agents, colorants, preservatives, fillers, and pH adjusters.

20. A topical composition according to any one of claims 14 to 19, which is a skincare composition.

21. A topical composition according to any one of claims 14 to 20, which exists in the form of a cream, foam, lotion, gel, paste, or ointment.

22. A method for reducing dust adhesion to the skin, comprising applying a topical composition according to any one of claims 14 to 21 to the skin.

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