Blood purification device

Abstract

To provide a blood purification device that makes it easy to set the conditions for blood purification therapy. [Solution] The blood purification device includes an acquisition unit that acquires setting information for setting a fluid removal rate profile, which is time-series information of the fluid removal rate during blood purification therapy; a calculation unit that calculates a fluid removal rate profile based on the setting information and calculates dependency information, which is information that depends on the fluid removal rate profile, based on the calculation result of the fluid removal rate profile; a display unit that displays a setting screen 10 in which a fluid removal rate graph G1, which is a graph of the fluid removal rate profile, and a dependency information graph, which is a graph of the dependency information, are simultaneously displayed; a display control unit that controls the display content of the display unit; and an input unit that moves a point P1 on the fluid removal rate graph G1 and a point P2 on the dependency information graph displayed on the setting screen 10. The display control unit updates the fluid removal rate graph G1 and the dependency information graph in response to either point P1 or P2 on the fluid removal rate graph G1 and the dependency information graph, which are simultaneously displayed on the setting screen 10, being moved using the input unit.

Description

Technical Field

[0001] The present invention relates to a blood purification device.

Background Art

[0002] Patent Document 1 discloses a blood purification device such as a dialysis device having a touch panel. The blood purification device described in Patent Document 1 is configured to perform area setting by touching two locations of an image such as a graph displayed on the touch panel, and to be able to expand and display the area set by the third touch operation.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] However, in the blood purification device described in Patent Document 1, there is room for improvement from the viewpoint of performing a screen display that facilitates setting the conditions for blood purification treatment, and it only simplifies the enlargement operation of the image.

[0005] The present invention has been made in view of the above circumstances, and an object thereof is to provide a blood purification device in which the conditions for blood purification treatment can be easily set.

Means for Solving the Problems

[0006] To achieve the above objective, the present invention provides a blood purification device to which a blood purifier is attached for administering blood purification therapy to a patient, comprising: an acquisition unit that acquires setting information for setting a water removal rate profile, which is time-dependent information of the water removal rate during blood purification therapy; a calculation unit that calculates the water removal rate profile based on the setting information and calculates dependency information, which is information dependent on the water removal rate profile, based on the calculation result of the water removal rate profile; a display unit that displays a setting screen, which is a screen for setting the water removal rate profile, where a water removal rate graph, which is a graph of the water removal rate profile, and a dependency information graph, which is a graph of the dependency information, are simultaneously displayed; a display control unit that controls the display content of the display unit; and an input unit that moves points on the water removal rate graph and points on the dependency information graph displayed on the setting screen, wherein the display control unit updates the water removal rate graph and the dependency information graph in response to either point on the water removal rate graph or the dependency information graph, which are simultaneously displayed on the setting screen, being moved using the input unit, thereby providing a blood purification device. [Effects of the Invention]

[0007] According to the present invention, it is possible to provide a blood purification device that makes it easy to set the conditions for blood purification therapy. [Brief explanation of the drawing]

[0008] [Figure 1] This is a perspective view of the blood purification device in the first embodiment. [Figure 2] This is a schematic diagram showing the configuration of the blood purification device in the first embodiment. [Figure 3] This is a flowchart illustrating the water removal rate profile setting process performed by the control unit in the first embodiment. [Figure 4] This figure shows the settings screen in the first embodiment. [Figure 5] This diagram shows the slide operation of the settings screen in the first embodiment. [Figure 6]This figure shows the state after sliding the settings screen in the first embodiment. [Figure 7] This figure shows the settings screen in the first embodiment where a warning notification is displayed. [Figure 8] This figure shows the settings screen in the first embodiment where a confirmation notification has been issued. [Figure 9] This figure shows the settings screen in the second embodiment. [Figure 10] This figure shows the settings screen in the third embodiment. [Modes for carrying out the invention]

[0009] [First Embodiment] A first embodiment of the present invention will be described with reference to Figures 1 to 8. The embodiments described below are presented as preferred specific examples for carrying out the present invention, and while some parts specifically illustrate various technically preferable technical matters, the technical scope of the present invention is not limited to these specific embodiments.

[0010] (Blood purification device 1) Figure 1 is a perspective view of the blood purification device 1 in this embodiment. Figure 2 is a schematic diagram showing the configuration of the blood purification device 1.

[0011] The blood purification device 1 is a device for purifying the blood of a patient undergoing extracorporeal circulation. In this embodiment, the blood purification device 1 is a dialysis machine capable of hemodialysis (HD) as a blood purification therapy. The blood purification device 1 may also be capable of other blood purification therapies such as hemofiltration (HF) or hemodiafiltration (HDF). Furthermore, the blood purification device 1 is equipped with a water removal function to remove water from the patient's blood.

[0012] As shown in FIG. 2, the blood purification device 1 is used with the blood circuit 11 attached. The blood circuit 11 is a circuit that circulates the blood of a patient undergoing extracorporeal circulation during blood purification treatment, and includes a blood purifier 111 that purifies the patient's blood, an arterial side channel 112 that allows the patient's blood to flow into the blood purifier 111, and a venous side channel 113 that returns the blood from the blood purifier 111 to the patient. The blood circuit 11 is a disposable component that is discarded after each blood purification treatment.

[0013] The blood purifier 111 is, for example, a dialyzer, and a large number of tubular hollow fiber membranes are arranged inside. A large number of fine holes (bores) penetrating from the outer peripheral surface to the inner peripheral surface are formed in the hollow fiber membrane. The blood purifier 111 has a blood inlet 111a for introducing blood inside the hollow fiber membrane and a blood outlet 111b for discharging the blood inside the hollow fiber membrane. Further, the blood purifier 111 has a dialysate inlet 111c for introducing dialysate around the hollow fiber membrane and a dialysate outlet 111d for discharging the dialysate around the hollow fiber membrane. In the blood purifier 111, excess water and waste products in the blood permeate to the dialysate side through the holes of the hollow fiber membrane, and components such as electrolytes in the dialysate that are lacking in the blood permeate to the blood side through the holes of the hollow fiber membrane.

[0014] The arterial side channel 112 is a channel that sends the patient's blood to the blood purifier 111 during blood purification treatment, and is composed of a flexible tube or the like. One end of the arterial side channel 112 is connected to the blood inlet 111a of the blood purifier 111. During blood purification treatment, an arterial side puncture needle that punctures the patient's artery is connected to the other end of the arterial side channel 112.

[0015] The venous side channel 113 is a channel that returns the blood purified by the blood purifier 111 to the patient during blood purification treatment, and is composed of a flexible tube or the like. One end of the venous side channel 113 is connected to the blood outlet 111b of the blood purifier 111. During blood purification treatment, a venous side puncture needle that punctures the patient's vein is connected to the other end of the venous side channel 113.

[0016] The blood purification device 1 includes a blood pump 2, a dialysate supply channel 3, a dialysate discharge channel 4, a balance control mechanism 5, a bypass line 6, a water removal pump 7, a touch panel 8, and a control unit 9. Note that the circuit diagram shown in FIG. 2 only extracts and shows the main components related to the blood purification device 1 in this form, and actually, there may be components other than those shown in FIG. 2.

[0017] The blood pump 2 is a pump for pumping the fluid in the blood circuit 11. During blood purification treatment, the blood pump 2 pumps the blood in the blood circuit 11 and circulates the patient's blood extracorporeally through the blood circuit 11. In this form, the blood pump 2 consists of a peristaltic pump to which a flexible tube constituting the arterial side channel 112 is attached, and the tube is squeezed to pump the blood toward the blood purifier 111 side.

[0018] The dialysate supply channel 3 is a channel for supplying dialysate to the blood purifier 111 during blood purification treatment, and is composed of a flexible tube, a rigid pipe, a channel block, etc. One end of the dialysate supply channel 3 is connected to the dialysate inlet 111c of the blood purifier 111.

[0019] The dialysate discharge channel 4 is a channel for discharging the drained dialysate from the blood purifier 111 to the outside during blood purification treatment, and is composed of a flexible tube, a rigid pipe, a channel block, etc. One end of the dialysate discharge channel 4 is connected to the dialysate outlet 111d of the blood purifier 111.

[0020] The balance control mechanism 5 is configured such that the liquid supply amount from the dialysate supply channel 3 to the blood purifier 111 and the liquid discharge amount from the blood purifier 111 to the dialysate discharge channel 4 are the same when the water removal pump 7 is not driven. The balance control mechanism 5 can be, for example, a compound pump connected to each of the dialysate supply channel 3 and the dialysate discharge channel 4.

[0021] The bypass line 6 is provided to bypass the point in the dialysate discharge channel 4 where the balance control mechanism 5 is connected. The bypass line 6 is composed of a flexible tube, rigid piping, a channel block, etc. A water removal pump 7 is provided in the bypass line 6.

[0022] The ultrafiltration pump 7, when driven, causes the amount of dialysate discharged from the blood purifier 111 to be greater than the amount of dialysate introduced into the blood purifier 111. In other words, ultrafiltration of the blood is performed when the ultrafiltration pump 7 is driven. The ultrafiltration pump 7 consists of, for example, a diaphragm pump, a piston pump, etc.

[0023] The touch panel 8 also functions as a display unit 81 for displaying predetermined information, an input unit 82 for receiving input via touch operation, and a notification unit 83 for providing predetermined notifications to the user. The touch panel 8 is not particularly limited, but for example, it is a capacitive touch panel. In particular, in this embodiment, the touch panel 8 is capable of sliding operation. The input unit 82 may be an input device such as a mouse. The notification unit 83 may be a speaker or the like that outputs predetermined notifications by sound.

[0024] The control unit 9 is implemented by appropriately combining a control area including a processor and RAM (Random Access Memory) which serves as the calculation area during processor operation, with interfaces and the like. The implementation method of the control unit 9 is not limited to software, as long as it is configured to realize its functions. For example, at least a part of the functions of the control unit 9 may be implemented using hardware such as logic circuits.

[0025] The control unit 9 comprises an acquisition unit 91, a calculation unit 92, a display control unit 93, and a storage unit 94.

[0026] The acquisition unit 91 acquires setting information for setting the ultrafiltration rate profile. The ultrafiltration rate profile is time-series information of the ultrafiltration rate during blood purification therapy and is set before the start of blood purification therapy. Setting information includes, for example, the total amount of ultrafiltration and the treatment time. For example, the acquisition unit 91 acquires setting information entered by operating the touch panel 8. The acquisition unit 91 may also receive setting information from, for example, an external personal computer, mobile terminal, etc.

[0027] The calculation unit 92 performs various calculations when setting the water removal rate profile. For example, the calculation unit 92 calculates the water removal rate profile based on the setting information acquired by the acquisition unit 91, and also calculates dependency information, which is information that depends on the water removal rate profile, based on the calculation result of the water removal rate profile. The calculation unit 92 calculates the water removal rate profile based on the setting information and the correlation between the setting information and the water removal rate profile (for example, a formula that expresses the water removal rate profile using the setting information and various coefficients). Such correlations are stored in advance in the storage unit 94.

[0028] Dependency information is information that depends on the ultrafiltration rate profile. In this embodiment, dependency information includes the ultrafiltration achievement rate profile, the uniform ultrafiltration rate profile over remaining time, and blood concentration information.

[0029] The ultrafiltration rate profile is time-series information on the ultrafiltration rate obtained by dividing the cumulative amount of ultrafiltration removed at each time point during blood purification therapy by the total amount of ultrafiltration removed. Since the cumulative amount of ultrafiltration removed at each time point during blood purification therapy depends on the ultrafiltration rate profile, the ultrafiltration rate profile is information that depends on the ultrafiltration rate profile.

[0030] The remaining time equalized ultrafiltration rate profile is time-series information of the remaining time equalized ultrafiltration rate, obtained by dividing the amount of remaining ultrafiltration at each time point in blood purification treatment by the remaining treatment time. Since the amount of remaining ultrafiltration at each time point in blood purification treatment depends on the ultrafiltration rate profile, the remaining time equalized ultrafiltration rate profile is information that depends on the ultrafiltration rate profile. During blood purification treatment, the ultrafiltration rate at each time point is controlled to exceed the remaining time equalized ultrafiltration rate.

[0031] Hemoconcentration information refers to information about the degree of concentration of a patient's blood. In this form, hemoconcentration information includes time-series data of the rate of change in circulating blood volume (ΔBV). ΔBV is an index that shows the relative change in circulating blood volume from a baseline time (e.g., the start of blood purification therapy) during blood purification therapy. Since the change in circulating blood volume depends on the ultrafiltration rate profile, the time-series data of ΔBV is information that depends on the ultrafiltration rate profile. ΔBV is calculated as an estimated value based on the ultrafiltration rate profile.

[0032] The calculation unit 92 calculates various dependency information based on the correlation between the set value of the water removal rate profile and various dependency information (for example, a mathematical formula that expresses the various dependency information using the set value of the water removal rate profile and various coefficients). Such correlations are stored in advance in the storage unit 94.

[0033] The display control unit 93 controls the display content of the touch panel 8, which serves as the display unit 81. In particular, in this embodiment, when setting the ultrafiltration rate profile performed before blood purification therapy, the display control unit 93 displays a setting screen 10 on the display unit 81 for setting the ultrafiltration rate profile. The setting screen 10 will be described later.

[0034] Furthermore, the control unit 9 performs blood purification therapy by controlling the operation of the blood pump 2, balance control mechanism 5, water removal pump 7, etc., during the treatment.

[0035] The storage unit 94 has memory such as ROM (Read Only Memory). The storage unit 94 stores various information used for setting the water removal rate profile. For example, the information stored in the storage unit 94 includes the correlation between setting information and the water removal rate profile, and the correlation between the set value of the water removal rate profile and various dependency information. The storage unit 94 also stores various programs for other processes executed by the control unit 9.

[0036] (Setting the water removal rate profile) Next, an example of the process for setting the ultrafiltration rate profile executed by the control unit 9 of the blood purification device 1 will be described. Figure 3 is a flowchart showing the ultrafiltration rate profile setting process executed by the control unit 9.

[0037] First, the acquisition unit 91 of the control unit 9 acquires the total amount of fluid removed and the total treatment time as setting information (step S1). The setting information is acquired by the user (for example, a medical professional such as a doctor) by touching the touch panel 8.

[0038] Next, the calculation unit 92 of the control unit 9 calculates the ultrafiltration rate profile, dependency information, and reference information based on the acquired setting information (step S2). In this embodiment, the ultrafiltration rate profile to be set is a profile in which the ultrafiltration rate gradually decreases from the start to the end of blood purification treatment. For example, the ultrafiltration rate profile is a profile in which the first rate of decrease (i.e., slope) of the ultrafiltration rate from the start of treatment to the time of reaching T-TAU described later (hereinafter referred to as the "first section"), the second rate of decrease of the ultrafiltration rate from the time of reaching T-TAU to the halfway point of the total treatment time (hereinafter referred to as the "second section"), and the third rate of decrease of the ultrafiltration rate from the halfway point of the total treatment time to the end of treatment (hereinafter referred to as the "third section") may differ.

[0039] In this configuration, the dependent information includes the ultrafiltration achievement rate profile, the remaining time uniform ultrafiltration rate profile, and the time-dependent information of ΔBV. The reference information is independent of the ultrafiltration rate profile and, in this configuration, includes the uniform ultrafiltration rate and the linear ultrafiltration achievement rate. The uniform ultrafiltration rate is a constant value obtained by dividing the total amount of ultrafiltration by the total treatment time. The linear ultrafiltration achievement rate is a profile in which the ultrafiltration achievement rate increases linearly from 0% to 100%.

[0040] In step S2, the calculation unit 92 calculates a water removal rate profile based on the acquired setting information. Then, the calculation unit 92 calculates various dependency information based on the calculation result of the water removal rate profile. In addition, the calculation unit 92 calculates the uniform water removal rate and the linear water removal achievement rate based on the acquired setting information.

[0041] Figure 4 shows the settings screen 10. Note that the hand shown in Figure 4 represents the user's hand and does not represent the screen display. Also, the arrows appearing near the hand indicate the direction of hand movement and do not represent the screen display. Following step S2, the display control unit 93 of the control unit 9 displays the settings screen 10, which is a screen for setting the water removal rate profile, on the display unit 81 (step S3). The settings screen 10 is a screen that simultaneously displays the water removal rate graph G1, which is a graph of the water removal rate profile, and the dependency information graph, which is a graph of the dependency information. In this embodiment, the water removal rate graph G1 and the dependency information graph are line diagrams, but scatter plots or the like may also be used.

[0042] The dependency information graph includes a water removal achievement rate graph G2, which graphs the water removal achievement rate profile; a remaining time equal water removal rate graph G3, which graphs the remaining time equal water removal rate profile; and a ΔBV graph G4, which graphs the time-series information of ΔBV. In this embodiment, the water removal rate graph G1, the water removal achievement rate graph G2, and the remaining time equal water removal rate graph G3 are drawn within the same graph frame in the settings screen 10. The ΔBV graph G4 includes a representative value shown by a solid line, and upper and lower limit lines of ΔBV based on the representative value, shown by dashed lines above and below the representative value. Furthermore, the area between the upper and lower limit lines may be colored to visually emphasize the range in which ΔBV is likely to take.

[0043] In addition, in this configuration, the settings screen 10 also displays a reference information graph that visualizes the reference information. The reference information graph consists of a uniform water removal rate line L1, which shows the uniform water removal rate, and a linear water removal achievement rate line L2, which shows the linear water removal achievement rate.

[0044] Furthermore, the settings screen 10 displays the first point P1 on the water removal rate graph G1 and the second point P2 on the water removal achievement rate graph G2. While the first point P1 and the second point P2 are shown as a circle in this example, they may also be in other shapes such as squares.

[0045] The first point P1 is a point displayed at a predetermined position on the line of the water removal rate graph G1, and is a point for accepting changes to the water removal rate graph G1. In this embodiment, the first point P1 indicates the time at which the water removal rate on the water removal rate graph G1 reaches a predetermined value (specifically, the uniform water removal rate) (hereinafter referred to as the T-TAU arrival time).

[0046] The second point P2 is a point displayed at a predetermined position on the line of the fluid removal achievement rate graph G2, and is a point for accepting changes to the fluid removal achievement rate graph G2. The second point P2 indicates the fluid removal achievement rate at a predetermined point in time from the start of treatment (specifically, at the halfway point) (hereinafter referred to as the first half fluid removal achievement rate).

[0047] The display control unit 93 then accepts movement operations for the first point P1 and the second point P2. In this embodiment, the display control unit 93 accepts sliding operations for the first point P1 in the time axis direction (left-right direction) and sliding operations for the second point P2 in the water removal achievement rate axis direction (up-down direction).

[0048] After the control unit 9 displays the setting screen 10 in step S3, if the display control unit 93 accepts the movement of the first point P1 or the second point P2 (i.e., proceeds to Yes in step S4), the calculation unit 92 updates the water removal rate profile and dependency information. This update may be performed, for example, during the slide operation, or after the slide operation is complete and the user's fingers have left the touch panel 8.

[0049] Figure 5 shows the slide operation on the settings screen 10. Note that the hand shown in Figure 5 represents the user's hand and not the screen display. Also, the arrows appearing near the hand indicate the direction of hand movement and not the screen display. Figure 6 shows the settings screen 10 after the slide operation. In Figure 6, the various lines before the change from Figure 5 are represented as virtual lines with dashed dots. For example, consider the case where the first point P1 is slid to the side that shortens the T-TAU arrival time (i.e., to the left), as shown in Figures 5 and 6. In this case, the calculation unit 92 updates the water removal rate profile based on the specified T-TAU arrival time (i.e., the position of the first point P1 after the slide operation) and a predetermined correction coefficient (step S5). The predetermined correction coefficient is, for example, a coefficient that corrects the first to third reduction rates mentioned above, and may take different values ​​depending on the specified T-TAU arrival time. The predetermined correction coefficient is stored in the storage unit 94 in advance. Then, based on the updated water removal rate profile settings, the dependency information (i.e., water removal achievement rate profile, remaining time uniform water removal rate profile, and ΔBV time-series information) is updated.

[0050] Furthermore, although not shown in the diagram, we will consider the case where the second point P2 is slid in the axis direction of the fluid removal achievement rate (i.e., vertical direction). In this case, the fluid removal achievement rate profile is updated based on the specified first-half fluid removal achievement rate and a predetermined correction coefficient (step S5). The predetermined correction coefficient is, for example, a coefficient used to calculate a coefficient that corrects the first to third reduction rates, and may take different values ​​depending on the specified first-half fluid removal achievement rate and total fluid removal amount. For example, the first-half fluid removal amount or the second-half fluid removal amount is calculated from the specified first-half fluid removal achievement rate and total fluid removal amount, the fluid removal amounts for the first to third sections during the treatment period are calculated based on the first-half fluid removal amount or the second-half fluid removal amount, and a coefficient that corrects the first to third reduction rates is calculated based on the fluid removal amounts for the first to third sections. The predetermined correction coefficient is stored in the memory unit 94 in advance. Then, based on the updated fluid removal achievement rate profile, the fluid removal rate profile and other dependent information (i.e., the remaining time uniform fluid removal rate profile and the time-dependent information of ΔBV) are updated.

[0051] Then, after the water removal rate profile and dependency information are updated (i.e., after step S5), the display control unit 93 updates and displays the water removal rate graph G1 and the dependency information graph in real time based on the updated water removal rate profile and dependency information. That is, when the first point P1 is slid as shown in Figure 5, not only the water removal rate graph G1 but also the water removal achievement rate graph G2, the remaining time uniform water removal rate graph G3, and the ΔBV graph G4 are updated simultaneously as shown in Figure 6. Real-time updates include not only cases where the water removal rate graph G1, water removal achievement rate graph G2, remaining time uniform water removal rate graph G3, and ΔBV graph G4 are updated simultaneously, but also cases where the update timing of each of the water removal rate graph G1, water removal achievement rate graph G2, remaining time uniform water removal rate graph G3, and ΔBV graph G4 is slightly off due to, for example, the processing capacity of the control unit 9.

[0052] Next, the calculation unit 92 determines whether there is an abnormality in at least one of the updated fluid removal rate profile and dependency information (step S7). This determination is made by comparing each of the fluid removal rate profile and dependency information with a threshold value defined for each. The threshold value is appropriately determined, for example, based on whether or not the patient may experience risks such as a drop in blood pressure.

[0053] Furthermore, if the calculation unit 92 determines that there is an abnormality in the fluid removal rate profile and dependency information, it determines whether the abnormality poses a significant risk to the patient (step S8). This determination is made by comparing each of the fluid removal rate profile and various dependency information with the threshold values ​​defined for each of them. These threshold values ​​are appropriately determined based, for example, on whether there is a very high probability that the patient may experience risks such as a drop in blood pressure.

[0054] If the risk is deemed high in step S8, the notification unit 83 issues a warning notification (step S9). Figure 7 shows the settings screen 10 with a warning notification. The warning notification informs the user that the setting change has been rejected. For example, as shown in the figure, the display unit 81 displays the message "The requested setting change cannot be performed because there is a high risk of blood pressure drop due to a rapid decrease in ΔBV." After the warning notification is issued, the update of the fluid removal rate profile and dependency information is rejected, and the fluid removal rate profile, dependency information, and their graphs are reverted to the previous values ​​or initial values ​​(step S10).

[0055] On the other hand, if it is determined in step S8 that the risk is not significant, the notification unit 83 issues a confirmation notification (step S11). Figure 8 shows the settings screen 10 with the confirmation notification displayed. The confirmation notification prompts the user to confirm whether or not to proceed with the setting change. For example, as shown in Figure 8, the display unit 81 displays the message "There is a risk of blood pressure drop due to a sudden drop in ΔBV. Do you want to proceed with the setting change?" along with buttons to select either "Yes" or "No". If the user touches "Yes", the update of the ultrafiltration rate profile and dependency information is permitted. On the other hand, if the user touches "No", the process proceeds to step S10, where the update of the ultrafiltration rate profile and dependency information is rejected, and the ultrafiltration rate profile, dependency information, and their graphs are returned to their previous values ​​or initial values.

[0056] If no movement operation is performed for either the first point P1 or the second point P2 in step S4, if it is determined that there is no abnormality in step S7, or if "Yes" is touched after step S10 or in step S11, it is determined whether or not a setting completion action has occurred (step S12). A setting completion action can be performed, for example, by the user touching a predetermined button on the display unit 81 or by operating a predetermined physical switch on the blood purification device 1. If there is no setting completion action, the process returns to step S4. On the other hand, if a setting completion action has occurred, the setting of the ultrafiltration rate profile is finalized. After that, the blood purification device 1 receives a predetermined action for starting blood purification treatment and then performs blood purification treatment based on the set ultrafiltration rate profile.

[0057] (Operation and effects of the first embodiment) In this embodiment of the blood purification device 1, the display control unit 93 updates the ultrafiltration rate graph G1 and the dependency information graph in response to any point P1 or P2 on the ultrafiltration rate graph G1 and the dependency information graph, which are simultaneously displayed on the setting screen 10, being moved using the input unit 82. In this way, both the ultrafiltration rate graph G1 and the dependency information graph can be changed by manipulating points P1 and P2 on the graph, allowing for intuitive changes to the ultrafiltration rate profile settings. Furthermore, since the user can set the ultrafiltration rate profile while referring to real-time information on both the ultrafiltration rate graph G1 and the dependency information graph, setting the ultrafiltration rate profile becomes easier.

[0058] Furthermore, the display unit 81 and input unit 82 are configured as a touch panel 8, and the display control unit 93 updates the water removal rate graph G1 and the dependency information graph in response to any point P1 or P2 on the water removal rate graph G1 and dependency information graph, which are simultaneously displayed on the setting screen 10, being slid.Therefore, changing the water removal rate profile settings becomes even more intuitive.

[0059] Furthermore, the display control unit 93 updates the water removal rate graph G1 and the water removal achievement rate graph G2, which are simultaneously displayed on the setting screen 10, in response to any point P1 or P2 on the graph using the input unit 82. This makes it easier to check the water removal achievement rate profile when setting the water removal rate profile.

[0060] Furthermore, the dependency information includes a remaining time uniform water removal rate profile. The display control unit 93 updates the water removal rate graph G1, the water removal achievement rate graph G2, and the remaining time uniform water removal rate graph G3, which are simultaneously displayed on the setting screen 10, in response to any point P1 or P2 on the water removal rate graph G1 or the water removal achievement rate graph G2 being moved using the input unit 82. The remaining time uniform water removal rate profile indicates the minimum water removal rate required to reach the target amount of water removal, making it easy to check the remaining time uniform water removal rate profile when setting the water removal rate profile.

[0061] Furthermore, the dependency information includes hemoconcentration information, which is information related to hemoconcentration. The display control unit 93 updates the ultrafiltration rate graph G1, the ultrafiltration achievement rate graph G2, and the hemoconcentration information graph, which are simultaneously displayed on the setting screen 10, in response to any points P1 or P2 on the ultrafiltration rate graph G1 and the ultrafiltration achievement rate graph G2 being moved using the input unit 82. Therefore, when setting the ultrafiltration rate profile, it becomes easy to check information related to hemoconcentration, that is, information related to risks such as a decrease in the patient's blood pressure.

[0062] Furthermore, the blood concentration information includes time-series information on ΔBV. Time-series information on ΔBV (e.g., the degree of decrease over time) is information that greatly influences the patient's blood pressure decrease, and with this configuration, when changing the settings of the ultrafiltration rate profile, it becomes easier to grasp the risk of the patient's blood pressure decrease from the time-series information on ΔBV.

[0063] Furthermore, the notification unit 83 notifies the user if at least one of the water removal rate profile and dependency information contains an abnormal value. Therefore, the user is prompted to set the water removal rate profile to fall within the normal range.

[0064] As described above, this embodiment makes it possible to provide a blood purification device that facilitates the setting of conditions for blood purification therapy.

[0065] [Second Embodiment] A second embodiment of the present invention will be described with reference to Figure 9. Figure 9 is a diagram showing the settings screen 10 in this embodiment. Note that the hand shown in Figure 9 represents the user's hand and does not represent the screen display. Also, the arrows appearing near the hand indicate the direction of hand movement and do not represent the screen display.

[0066] This embodiment is a modified version of the first embodiment, with a change to the settings screen 10. Specifically, in this embodiment, in addition to the ultrafiltration rate graph G1, ultrafiltration achievement rate graph G2, time-equal ultrafiltration rate graph G3, and ΔBV graph G4 that were displayed on the settings screen 10 in the first embodiment, the settings screen 10 also displays information regarding the cumulative plasma ultrafiltration profile, the cumulative interstitial ultrafiltration profile, and the ultrafiltration ratio profile as dependent information. In this embodiment, unlike the first embodiment, the ultrafiltration rate graph G1 and the ultrafiltration achievement rate graph G2 are displayed in separate graph frames.

[0067] The plasma ultrafiltration cumulative volume profile is time-series information on the cumulative amount of ultrafiltration removed from plasma at each point in time during blood purification therapy. The interstitial ultrafiltration cumulative volume profile is time-series information on the cumulative amount of ultrafiltration removed from the interstitium at each point in time during blood purification therapy. In Figure 9, a boundary line B is drawn in the column of the ultrafiltration achievement rate graph G2, with the area A1 below the boundary line showing the plasma ultrafiltration cumulative volume profile, and the area A2 above the boundary line showing the interstitial ultrafiltration cumulative volume profile. These areas A1 and A2 can be distinguished, for example, by being represented by different colors. As mentioned above, the plasma ultrafiltration cumulative volume profile and the interstitial ultrafiltration cumulative volume profile are both dependent information and information indicating hemoconcentration. As ultrafiltration progresses, water (plasma) is removed from the blood, and the circulating blood volume decreases, the protein concentration in the blood increases, and water moves from the interstitium to the blood vessels due to the difference in osmotic pressure between the inside and outside of the blood vessels (interstitium) in the patient's body (plasma refilling). In other words, during blood purification therapy, as fluid removal progresses, fluid movement from the interstitium to the blood vessels (i.e., fluid removal from the interstitium) also progresses. In particular, if the amount of fluid removed from the plasma is excessive, the risk of hypotension increases.

[0068] The ultrafiltration ratio profile is time-series information on the ratio of the cumulative amount of ultrafiltration removed from plasma or interstitial tissue to the cumulative amount of ultrafiltration removed at each time point in blood purification therapy. In this form, the ultrafiltration ratio profile is shown in ultrafiltration ratio graph G5, which plots the ratio obtained by dividing the cumulative amount of ultrafiltration removed from the interstitial tissue by the total cumulative amount of ultrafiltration removed at each time point in blood purification therapy. As mentioned above, the ultrafiltration ratio profile is both dependent information and information indicating hemoconcentration.

[0069] Similar to the first embodiment, when setting the ultrafiltration rate profile, the first point P1 on the ultrafiltration rate graph G1 and the second point P2 on the ultrafiltration achievement rate graph G2 are accepted as slide operations. When a slide operation is accepted, the ultrafiltration rate profile, ultrafiltration achievement rate profile, time-series ultrafiltration rate profile, ΔBV time-series information, plasma ultrafiltration cumulative volume profile, interstitial ultrafiltration cumulative volume profile, and ultrafiltration ratio profile are updated, and these graphs are updated in real time.

[0070] In this configuration, past performance data PD is also plotted on the ΔBV graph G4 as reference information. The past performance data PD may be measured values ​​of the past ΔBV trends of patients undergoing blood purification therapy, or measured values ​​of the past ΔBV trends of patients with similar medical conditions to those undergoing blood purification therapy. The past performance data PD is stored in the memory unit 94. The past performance data PD is data that is not affected by changes in the ultrafiltration rate profile.

[0071] Furthermore, the ultrafiltration ratio graph G5 shows the recommended range A3 for the ratio of ultrafiltration removed from the interstitial tissue to the total ultrafiltration removed at the end of blood purification therapy. The recommended range A3 is determined statistically or by user settings and is stored in the memory unit 94. By displaying the recommended range A3, it is possible to consider whether the value of the ultrafiltration ratio graph G5 at the end of treatment falls within the recommended range when setting the ultrafiltration profile. The recommended range A3 is data that is not affected by changes in the ultrafiltration rate profile.

[0072] Otherwise, it is the same as in the first embodiment. In addition, among the reference numerals used in the second embodiment and subsequent embodiments, those that are the same as those used in the previously described embodiments represent the same components, etc., as those in the previously described embodiments, unless otherwise specified.

[0073] (Operation and effects of the second embodiment) In this configuration, when changing the ultrafiltration rate profile settings, the cumulative plasma ultrafiltration rate profile, the cumulative interstitial ultrafiltration rate profile, and the ultrafiltration ratio profile can be checked. From these, risks such as a drop in the patient's blood pressure can be identified (for example, excessive ultrafiltration from plasma increases the risk of causing a drop in the patient's blood pressure), making it easier to change the ultrafiltration rate profile settings. Furthermore, it has the same functions and effects as the first embodiment.

[0074] [Third Embodiment] A third embodiment of the present invention will be described with reference to Figure 10. Figure 10 is a diagram showing the settings screen 10 in this embodiment.

[0075] This embodiment is a modified version of the second embodiment, with a change to the settings screen 10. In this embodiment, the settings screen 10 displays a first button B1 indicating the direction of movement of a first point P1 on the water removal rate graph, and a second button B2 indicating the direction of movement of a second point P2 on the water removal achievement rate graph G2. The first button B1 is represented by a triangular symbol with its vertex pointing in the direction of movement, for example, to indicate movement of point P1 in either the left or right direction. The second button B2 is represented by a triangular symbol with its vertex pointing in the direction of movement, for example, to indicate movement of point P2 in either the up or down direction. In this embodiment, button B1 is displayed outside the graph, near the numerical display showing the T-TAU arrival time, and button B2 is displayed outside the graph, near the numerical display showing the first half water removal achievement rate. However, this is not limited to this, and for example, button B1 may be displayed near point P1 and button B2 may be displayed near point P2.

[0076] In this configuration, when setting the ultrafiltration rate profile, a touch operation of button B1 or button B2 is accepted. When a touch operation is accepted, the ultrafiltration rate profile, ultrafiltration achievement rate profile, uniform ultrafiltration rate profile over remaining time, time-dependent information of ΔBV, cumulative plasma ultrafiltration volume profile, cumulative interstitial ultrafiltration volume profile, and ultrafiltration ratio profile are updated, and these graphs are updated in real time. For example, if the triangular symbol with the vertex pointing to the left of button B1 is touched, the time to reach T-TAU decreases by a predetermined value, and the ultrafiltration rate profile, ultrafiltration achievement rate profile, uniform ultrafiltration rate profile over remaining time, time-dependent information of ΔBV, cumulative plasma ultrafiltration volume profile, cumulative interstitial ultrafiltration volume profile, and ultrafiltration ratio profile are updated, and these graphs are updated in real time. The amount of decrease in the time to reach T-TAU may be determined by the number of touch operations (for example, the number of times touch operations are performed at short time intervals) or by the duration of the long press operation. In addition, similar to the first embodiment, the ultrafiltration rate profile, ultrafiltration achievement rate profile, remaining time uniform ultrafiltration rate profile, time-dependent information of ΔBV, cumulative plasma ultrafiltration volume profile, cumulative interstitial ultrafiltration volume profile, and ultrafiltration ratio profile, as well as the real-time updates of these graphs, may also be performed by sliding points P1 and P2. Otherwise, it is the same as in the first embodiment.

[0077] (Operation and effects of the third embodiment) In this configuration, the display unit 81 and the input unit 82 are configured as a touch panel 8, and the display control unit 93 updates the water removal rate graph G1 and the dependency information graph in response to touch operations on buttons B1 and B2, which indicate the direction of movement of any of the points P1 and P2 on the water removal rate graph G1 and the dependency information graph, which are simultaneously displayed on the setting screen 10. Therefore, changing the water removal rate profile settings becomes even more intuitive. Furthermore, it has the same functions and effects as the first embodiment.

[0078] (Summary of the embodiments) Next, the technical concept understood from the embodiments described above will be described using the reference numerals and other symbols from the embodiments. However, the reference numerals and other symbols in the following description are not limited to the components in the claims that are specifically shown in the embodiments.

[0079] [1] A first embodiment of the present invention is a blood purification device 1 to which a blood purifier 111 for administering blood purification therapy to a patient is attached, comprising: an acquisition unit 91 for acquiring setting information for setting a water removal rate profile, which is time-dependent information of the water removal rate during blood purification therapy; a calculation unit 92 that calculates the water removal rate profile based on the setting information and calculates dependency information, which is information dependent on the water removal rate profile, based on the calculation result of the water removal rate profile; and a water removal rate graph G1 which graphs the water removal rate profile and a dependency information graph which graphs the dependency information are displayed simultaneously. The blood purification device 1 comprises a display unit 81 that displays a setting screen 10 which is a screen for setting the water removal rate profile, a display control unit 93 that controls the display content of the display unit 81, and an input unit 82 that moves a point P1 on the water removal rate graph G1 and a point P2 on the dependency information graph displayed on the setting screen 10, wherein the display control unit 93 updates the water removal rate graph G1 and the dependency information graph in response to any point P1 or P2 on the water removal rate graph G1 and the dependency information graph, which are simultaneously displayed on the setting screen 10, being moved using the input unit 82. This makes it easier to set the conditions for blood purification therapy.

[0080] [2] In a second embodiment of the present invention, in the first embodiment, the display unit 81 and the input unit 82 are configured as a touch panel 8, and the display control unit 93 updates the water removal rate graph G1 and the dependency information graph in response to any point P1 or P2 on the water removal rate graph G1 and the dependency information graph, which are simultaneously displayed on the setting screen 10, being slid. This makes it easier to intuitively change the settings of the water removal rate profile.

[0081] [3] A third embodiment of the present invention is that, in the first or second embodiment, the display unit 81 and the input unit 82 are configured as a touch panel 8, and the display control unit 93 updates the water removal rate graph G1 and the dependency information graph in response to a touch operation of buttons B1 and B2 which indicate the direction of movement of any of the points P1 and P2 on the water removal rate graph G1 and the dependency information graph that are simultaneously displayed on the setting screen 10. This makes it easier to intuitively change the settings of the water removal rate profile.

[0082] [4] A fourth embodiment of the present invention is that, in any one of the first to third embodiments, the acquisition unit 91 receives the total amount of fluid removed as the setting information, the dependency information includes a fluid removal achievement rate profile which is time-series information of the fluid removal achievement rate obtained by dividing the cumulative amount of fluid removed at each point in time during blood purification therapy by the total amount of fluid removed, and the display control unit 93 updates the fluid removal rate graph G1 and the fluid removal achievement rate graph G2, which graphs the fluid removal achievement rate profile and are simultaneously displayed on the setting screen 10, in response to any point P1, P2 on the fluid removal rate graph G1 and the fluid removal achievement rate graph G2 being moved using the input unit 82. This makes it easier to check the water removal achievement rate profile when setting the water removal rate profile.

[0083] [5] A fifth embodiment of the present invention is, in the fourth embodiment, the acquisition unit 91 further receives the total treatment time as the setting information, and the dependency information further includes a remaining time equalized water removal rate profile, which is time-series information of the remaining time equalized water removal rate obtained by dividing the remaining amount of water removed at each point in the blood purification treatment by the remaining treatment time, and the display control unit 93 updates the water removal rate graph G1, the water removal achievement rate graph G2, and the remaining time equalized water removal rate graph G3, which are all displayed simultaneously on the setting screen 10, in response to any point P1, P2 on the water removal rate graph G1 and the water removal achievement rate graph G2 being moved using the input unit 82. This makes it easier to check the remaining time uniform water removal rate profile when setting the water removal rate profile.

[0084] [6] A sixth embodiment of the present invention, in the fourth or fifth embodiment, further includes blood concentration information, which is information relating to blood concentration, and the display control unit 93 updates the blood concentration information graph, the blood concentration rate graph G1, the blood concentration information graph, and the blood concentration rate graph, which are simultaneously displayed on the setting screen 10, in response to any point P1 or P2 on the blood concentration rate graph G1 or the blood concentration information graph G2 being moved using the input unit 82. This makes it easier to check information about hemoconcentration, i.e., information about risks such as a drop in the patient's blood pressure, when setting the fluid removal rate profile.

[0085] [7] A seventh embodiment of the present invention, in the sixth embodiment, is that the hemoconcentration information includes at least one of the following: time-series information of the rate of change in circulating blood volume (ΔBV); a plasma ultrafiltration profile, which is time-series information of the cumulative amount of ultrafiltration removed from plasma at each time point in the hemopurification treatment; an interstitial ultrafiltration profile, which is time-series information of the cumulative amount of ultrafiltration removed from the interstitium at each time point in the hemopurification treatment; and an ultrafiltration ratio profile, which is time-series information of the ratio of the cumulative amount of ultrafiltration removed from plasma or the interstitium to the cumulative amount of ultrafiltration removed at each time point in the hemopurification treatment. This makes it easier to identify the risk of a patient's blood pressure drop when setting the fluid removal rate profile.

[0086] [8] An eighth embodiment of the present invention further includes a notification unit 83 that notifies the user if any one of the first to seventh embodiments contains an abnormal value in the water removal rate profile and the dependency information. This prompts the system to ensure that the water removal rate profile settings fall within the normal range.

[0087] (Note) Although embodiments of the present invention have been described above, the embodiments described herein do not limit the invention as defined in the claims. Furthermore, it should be noted that not all combinations of features described in the embodiments are necessarily essential for solving the problem of the invention. Moreover, the present invention can be implemented with appropriate modifications without departing from its spirit. [Explanation of Symbols]

[0088] 1…Blood purification device 10...Settings screen 111... Blood purifier 8…Touch panel 81...Display section 82...Input section 83…Notification department 91…Acquisition part 92...Arithmetic section 93...Display Control Unit G1...Water removal rate graph G2...Water removal achievement rate graph G3…Remaining time equal water removal speed graph P1...First point P2... Second point

Claims

1. A blood purification device to which a blood purifier is attached for administering blood purification therapy to a patient, An acquisition unit that acquires setting information for setting the ultrafiltration rate profile, which is time-series information on the ultrafiltration rate during blood purification therapy, A calculation unit that calculates the water removal rate profile based on the setting information and calculates dependency information, which is information that depends on the water removal rate profile, based on the calculation result of the water removal rate profile, A display unit that displays a setting screen, which is a screen for setting the water removal rate profile, and a screen that simultaneously displays a water removal rate graph, which is a graph of the dependency information, and a water removal rate graph, which is a screen that is a graph of the dependency information, A display control unit that controls the display content of the display unit, The system includes an input unit for moving points on the water removal rate graph and points on the dependency information graph displayed on the settings screen, The display control unit updates the water removal rate graph and the dependency information graph in response to any point on the water removal rate graph and the dependency information graph, which are simultaneously displayed on the setting screen, being moved using the input unit. Blood purification device.

2. The display unit and the input unit are configured as touch panels. The display control unit updates the water removal rate graph and the dependency information graph in response to a slide operation on any point on the water removal rate graph and the dependency information graph that are simultaneously displayed on the setting screen. The blood purification device according to claim 1.

3. The display unit and the input unit are configured as touch panels. The display control unit updates the water removal rate graph and the dependency information graph in response to a touch operation of a button indicating the direction of movement of any point on the water removal rate graph and the dependency information graph, which are simultaneously displayed on the setting screen. A blood purification device according to claim 1 or 2.

4. The acquisition unit receives the total amount of water removed as the setting information, The aforementioned dependency information includes a fluid removal achievement rate profile, which is time-series information of the fluid removal achievement rate obtained by dividing the cumulative amount of fluid removed at each point in time during blood purification therapy by the total amount of fluid removed. The display control unit updates the water removal rate graph and the water removal achievement rate graph, which graphs the water removal achievement rate profile and are simultaneously displayed on the setting screen, in response to any point on the graph being moved using the input unit. A blood purification device according to claim 1 or 2.

5. The acquisition unit further receives the total treatment time as setting information, The dependency information further includes a residual time equalization rate profile, which is time-series information of the residual time equalization rate of fluid removal obtained by dividing the residual fluid removal amount at each time point in the blood purification treatment by the remaining treatment time. The display control unit updates the water removal rate graph, the water removal achievement rate graph, and the remaining time equal water removal rate graph, which are all displayed simultaneously on the setting screen, when any point on the water removal rate graph or the water removal achievement rate graph is moved using the input unit. The blood purification device according to claim 4.

6. The aforementioned dependency information further includes hemoconcentration information, which is information relating to hemoconcentration. The display control unit updates the water removal rate graph, the water removal achievement rate graph, and the blood concentration information graph, which are graphs of blood concentration information, in response to any point on the water removal rate graph or the water removal achievement rate graph, which are simultaneously displayed on the setting screen, being moved using the input unit. The blood purification device according to claim 4.

7. The blood concentration information includes at least one of the following: time-series information on the rate of change in circulating blood volume (ΔBV); a plasma ultrafiltration profile, which is time-series information on the cumulative amount of ultrafiltration removed from plasma at each time point in the blood purification treatment; an interstitial ultrafiltration profile, which is time-series information on the cumulative amount of ultrafiltration removed from the interstitial cavity at each time point in the blood purification treatment; and an ultrafiltration ratio profile, which is time-series information on the ratio of the cumulative amount of ultrafiltration removed from plasma or the interstitial cavity to the total amount of ultrafiltration removed at each time point in the blood purification treatment. The blood purification device according to claim 6.

8. The system further includes a notification unit that notifies the user if at least one of the water removal rate profile and the dependency information contains an abnormal value. A blood purification device according to claim 1 or 2.

Images