Sample extraction device and inspection system

Abstract

To provide a sample take-out device capable of reducing contamination of a storage container, and an inspection system.SOLUTION: An extraction device 50 is a sample take-out device for taking out a sample taken from a living body. The extraction device 50 includes: a storage container holding unit 51 that holds a storage container of the sample and can be arranged in a sample receiving unit where the sample is supplied to the storage container and a take-out unit for discharging the sample from the storage container to a predetermined place; a housing 100 for covering the storage container holding unit 51 and the take-out unit; and a supply unit 100M for supplying the sample from outside of the housing 100 to the storage container in the housing 100.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present invention relates to a sample extraction device and an inspection system.

Background Art

[0002] An inspection for detecting a virus or the like from a sample is performed as follows. First, an inspector such as a doctor and a nurse collects a sample such as saliva or nasal discharge from the pharynx or nasal cavity of the subject using a cotton swab or the like. Next, the cotton swab or the like with the sample attached is immersed in an extractant to extract the sample. After that, the sample extracted into the extractant is dropped at a predetermined location and reacted with a reagent to perform the inspection.

[0003] In addition, in such an inspection field, automation has been promoted (see, for example, Patent Documents 1 and 2).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Summary of the Invention

Problems to be Solved by the Invention

[0005] In such an inspection, although automation has been promoted as described above, a certain degree of experience and skill are required for inspection steps such as sample extraction, and when performed by an inspector who is not familiar with sample handling, there is a problem that it is difficult to perform the inspection with high precision and safety. In particular, for an inexperienced inspector, it is difficult to handle the storage container for the sample, and contamination of the storage container is likely to occur.

[0006] This invention has been made in view of the above circumstances, and the object of this invention is to provide a sample extraction device and inspection system that can reduce contamination of the containment container. [Means for solving the problem]

[0007] The above objective of the present invention is achieved by the following:

[0008] (1) A sample extraction device for extracting a sample contained in a container, comprising: a container holding unit for holding the container; an extraction unit for extracting the sample contained in the container from the container; a housing covering the container holding unit and the extraction unit; and a supply unit for supplying the sample from outside the housing to the container inside the housing.

[0009] (2) The sample extraction device according to (1) above, wherein the extraction unit extracts the sample by discharging it from the containment container.

[0010] (3) The sample extraction device according to (2) above, further comprising an extraction unit for discharging the sample from the storage container.

[0011] (4) A sample extraction device according to any one of (1) to (3) above, wherein the sample is supplied from outside the housing to the container held by the container holding unit via the supply unit.

[0012] (5) The sample extraction device according to (4) above, wherein the container holding part is configured to be configurable for a sample receiving part for supplying the sample to the container and a extraction part.

[0013] (6) The sample removal device according to (5) above, further comprising a displacement mechanism that positions the container holding portion between the sample receiving portion and the removal portion.

[0014] (7) The sample removal device according to (6) above, further comprising a support portion that rotatably supports the container holding portion, wherein the displacement mechanism includes a drive portion that rotates the support portion on an axis.

[0015] (8) The sample extraction device according to any one of (5) to (7) above, wherein the container holding section is further configured to be configurable to include an installation section for placing an empty container in the container holding section and a disposal preparation section for disposing of the container from the container holding section to a disposal section.

[0016] (9) The sample removal device according to (8) above, wherein the waste disposal section is provided below the container holding section.

[0017] (10) The sample extraction device according to (8) or (9) above, further comprising a waste mechanism for guiding the containment container to the waste section.

[0018] (11) The sample removal device according to (10), wherein the disposal mechanism is configured to be movable in the vertical direction and includes an extrusion member that pushes up the containment container located in the disposal preparation section, and a guide member that guides the containment container, which has been pushed up by the extrusion member, to the disposal section.

[0019] (12) The sample extraction device according to any one of (1) to (11) above, further comprising a standby section for holding an empty container.

[0020] (13) The sample extraction device according to (12), further comprising a pair of rotating members that are rotatably held and have recesses that engage with flanges provided on the containment container, wherein the standby section is provided between the pair of rotating members.

[0021] (14) The sample extraction device according to (12) or (13) above, wherein the standby section is provided above the container holding section.

[0022] (15) The sample extraction device according to any one of (1) to (14) above, wherein the supply unit is an opening provided in the housing.

[0023] (16) The sample extraction device according to (15) above, further comprising a shielding part capable of shielding the opening.

[0024] (17) The sample extraction device according to (16) above, further comprising a locking member for fixing the shielding part at a position for shielding the opening.

[0025] (18) The sample extraction device according to (16) or (17) above, further comprising a first detection part for detecting shielding and exposure of the opening by the shielding part.

[0026] (19) The sample extraction device according to any one of (1) to (18) above, further comprising a second detection part for detecting that the container holding part is disposed at a position close to the supply part.

[0027] (20) The sample extraction device according to any one of (1) to (19) above, further comprising a third detection part for detecting a person or an object existing within a predetermined range from the supply part.

[0028] (21) The sample extraction device according to any one of (1) to (20) above, wherein the sampling tool to which the sample adheres is supplied from the outside of the housing to the storage container through the supply part.

[0029] (22) In the extraction part, the sample extracted by the extractant is taken out. The sample extraction device according to any one of (1) to (21) above.

[0030] (23) The sample extraction device according to (22) above, further comprising an extractant storage part for storing the extractant, and the extractant is supplied from the extractant storage part to the storage container.

[0031] (24) In the container holding part, one of the storage containers is held. The sample extraction device according to any one of (1) to (23) above.

[0032] (25) An inspection system comprising a sample extraction device as described in any of (1) to (24) above, a detection unit for receiving the sample extracted in the extraction unit, a reagent supply unit for supplying a reagent to the detection unit, and an optical measurement unit for measuring the optical properties of the sample and the reagent supplied to the detection unit. [Effects of the Invention]

[0033] According to the sample extraction device and inspection system of the present invention, a supply unit is provided for supplying a sample from outside the housing to a storage container inside the housing. This allows the inspector to supply a sample to the storage container from outside the housing without touching the storage container. Thus, contamination of the storage container can be reduced. [Brief explanation of the drawing]

[0034] [Figure 1] A perspective view showing an example of the overall configuration of an inspection system according to one embodiment. [Figure 2] Figure 1 is a block diagram showing an example of the configuration of the extraction apparatus. [Figure 3] Figure 1 shows a perspective view illustrating an example of the configuration of the holding part. [Figure 4] Figure 3 is a cross-sectional view showing an example of the configuration of the containment container. [Figure 5] Figure 2 is a block diagram showing an example of the configuration of the supply mechanism. [Figure 6] Figure 2 is a block diagram showing an example of the configuration of the discharge mechanism. [Figure 7] Figure 3 is a perspective view showing an example of the configuration of the waste preparation unit. [Figure 8] Figure 2 is a block diagram showing an example of the configuration of the waste disposal mechanism. [Figure 9] Figure 7 is a perspective view showing an example of the configuration of the guide section. [Figure 10] Figure 3 is a perspective view showing an example of the configuration of the installation unit. [Figure 11] Figure 2 is a block diagram showing an example of the configuration of the standby mechanism. [Figure 12] Figure 2 is a block diagram showing an example of the configuration of the displacement mechanism. [Figure 13] Figure 2 is a flowchart illustrating an example of the operation of the extraction device. [Figure 14] This is a plan view illustrating the schematic configuration of the side view of the inspection device shown in Figure 1. [Figure 15] Figure 14 is a plan view showing the configuration of the top surface of the inspection device. [Figure 16] (A) is a plan view showing the side configuration of the detection unit shown in Figure 14, etc., and (B) is a plan view showing the top configuration of the detection unit shown in (A). [Figure 17] This flowchart shows an example of an inspection method using the inspection system shown in Figure 1. [Figure 18] This is a block diagram showing an example of the configuration of an extraction device according to a modified example. [Modes for carrying out the invention]

[0035] The embodiments of the sample extraction device and inspection system of the present invention will be described below with reference to the attached drawings. In the drawings, the same reference numerals are used for the same components. Also, the dimensional ratios in the drawings are exaggerated for illustrative purposes and may differ from the actual ratios.

[0036] (Embodiment) <Overall configuration of the inspection system> Figure 1 shows an example of the overall configuration of an inspection system 1 according to one embodiment of the present invention. The inspection system 1 includes an extraction device 50 and an inspection device 60 provided inside a housing 100. For example, the extraction device 50 is provided on one side (left side of the page) inside the housing 100, and the inspection device 60 is provided on the other side (right side of the page). Hereinafter, the direction in which the extraction device 50 and the inspection device 60 are arranged is referred to as the left-right direction or X direction, and the direction perpendicular to the ground surface (ground) of the inspection system 1 is referred to as the up-down direction or Z direction.

[0037] The housing 100 has, for example, a recess 100R in the upper left, and a supply unit 100M is provided on the bottom surface of this recess 100R. The supply unit 100M is an opening provided in the housing 100. The inspection system 1 has a shielding unit 100S that can shield the supply unit 100M. The shielding unit 100S is, for example, made of a plate-shaped member that can shield the recess 100R in which the supply unit 100M is provided, and one end thereof is fixed to the housing 100. The shielding unit 100S is, for example, configured to be rotatable around the one end fixed to the housing 100 as an axis. The shielding unit 100S may shield the supply unit 100M by sliding. By having the shielding unit 100S, the inspection system 1 can prevent contaminants from flowing from the supply unit 100M into the inspection system 1.

[0038] The extraction device 50, located within the housing 100, primarily plays the role of extracting the subject's biological sample (hereinafter simply referred to as "sample") attached to a collection tool such as a cotton swab (for example, collection tool C in Figure 4, described later) using an extraction agent, and then removing the extracted sample to a predetermined location. In the testing device 60, for example, the sample and reagent are mixed at the location where the sample is supplied, and the test is performed. Here, the extraction device 50 corresponds to one specific example of the sample removal device of the present invention.

[0039] <Configuration of the extraction device> Figure 2 is a block diagram showing an example of the configuration of the extraction device 50. The extraction device 50 includes, for example, a container holding unit 51, a supply mechanism 52, a discharge mechanism 53, a waste disposal mechanism 54, a standby mechanism 55, and a displacement mechanism 56.

[0040] Figure 3 shows an example of the configuration of the container holder 51. The container holder 51 holds the container 500 in which the sample is contained. The container holder 51 has, for example, one circular hole 51H into which a conical container 500 fits, and the container 500 is held by being inserted into this hole 51H. By the container holder 51 holding only one container 500, the extraction device 50 and, consequently, the inspection system 1 can be miniaturized, and the flexibility of the installation location of the inspection system 1 can be increased. The container holder 51 is covered by the housing 100 (Figure 1). The sample is supplied from outside the housing 100 to the container 500 inside the housing 100 via a supply unit 100M provided in the housing 100.

[0041] The container holder 51 has, for example, a substantially elliptical planar shape, with one end supported by a support portion 511 and a hole 51H provided at the other end. The support portion 511 rotatably supports the container holder 51. The support portion 511 is, for example, composed of a shaft-like member and is configured to rotate on an axis. As the support portion 511 rotates on its axis, the container holder 51 rotates around one end, and the hole 51H is displaced. The container holder 51 rotates, for example, clockwise and counterclockwise. As the container holder 51 rotates, the hole 51H (container container 500) is displaced into the sample receiving portion P1, the removal portion P2, the disposal preparation portion P3, and the installation portion P4. The sample receiving section P1, the extraction section P2, the waste preparation section P3, and the installation section P4 are arranged, for example, in a circular pattern, in the order of sample receiving section P1, extraction section P2, installation section P4, and waste preparation section P3 in a counterclockwise direction. By arranging the sample receiving section P1, extraction section P2, waste preparation section P3, and installation section P4 in a circular pattern, it becomes easier to miniaturize the extraction device 50. The sample receiving section P1, extraction section P2, waste preparation section P3, and installation section P4 are covered by the housing 100. A supply section 100M is provided at a position corresponding to the containment container 500 located in the sample receiving section P1.

[0042] Figure 4 shows an example of the cross-sectional configuration of a container 500 held by the container holder 51. The container 500 has, for example, a nozzle portion 500n and a storage portion 500c. The container 500 is preferably disposable, for example, and is used by replacing it once or several times.

[0043] The containment section 500c is sized to accommodate a sampling tool C, such as a cotton swab, and has an insertion opening 500I. The insertion opening 500I is provided, for example, on the bottom side of a conical containment container 500. The sampling tool C, to which the sample is attached, is inserted through this insertion opening 500I. The containment section 500c contains a predetermined amount of extractant along with the sampling tool C. The sample attached to the sampling tool C is extracted or dispersed in the extractant in the containment section 500c.

[0044] The container 500 has, for example, a flange 500B provided along the periphery of the insertion opening 500I. The flange 500B is a portion that protrudes from the insertion opening 500I in an overhang shape. That is, the container 500 has a flange 500B on the outside of the insertion opening 500I. The size of the hole 51H of the container holder 51 is, for example, larger than the diameter of the insertion opening 500I and smaller than the diameter of the flange 500B. As a result, the flange 500B widens from the hole 51H and the container 500 is held in the container holder 51.

[0045] The nozzle portion 500n is, for example, located at the apex of a conical container 500 and has a discharge port 500D. The sample extracted by the extractant in the container portion 500c is discharged from this discharge port 500D to a predetermined location.

[0046] The nozzle portion 500n is equipped with, for example, a filter 500F, and the sample and extractant that have passed through the filter 500F are discharged from the discharge port 500D. In other words, the sample and extractant heading toward the discharge port 500D pass through the filter 500F, and solid impurities and viscous impurities contained in the sample are removed by the filter 500F. By providing such a filter 500F inside the containment container 500, the occurrence of problems such as clogging of the discharge port 500D can be suppressed. The filter 500F is made of, for example, an organic material or an inorganic material. Examples of organic materials include polyethylene, polypropylene, fluororesin, and nylon resin.

[0047] In the retrieval section P2, the insertion opening 500I of the storage container 500 is covered by the lid 501 (see Figures 3 and 4). The lid 501 is held, for example, above the storage container holder 51, and when the storage container holder 51 is positioned in the retrieval section P2, it descends to a position where it contacts the flange 500B of the storage container 500.

[0048] The lid 501 has, for example, a substantially circular planar shape. When the insertion opening 500I is closed by the lid 501, the containment container 500 is sealed. The lid 501 is configured to be detachably attached to the insertion opening 500I, and the insertion opening 500I of the containment container 500 is opened in the sample receiving section P1, the disposal preparation section P3, and the installation section P4. The lid 501 is provided with, for example, a recess 501R, a sealing structure 501S, and a connection hole 501C.

[0049] The recess 501R is located, for example, near the center of the lid 501 and is provided on one of the main surfaces of the lid 501. In the removal section P2, the insertion opening 500I is closed so that the surface with the recess 501R faces the container 500. For example, a part of the sampling tool C inside the container 500 is inserted into this recess 501R. By providing such a recess 501R in the lid 501, the container 500 can be made smaller.

[0050] The sealing structure 501S is provided, for example, on the same surface as the surface on which the recess 501R is provided. This sealing structure 501S plays the role of tightly sealing the flange portion 500B and the lid portion 501 of the containment container 500. The sealing structure 501S is composed of an O-ring provided at a position corresponding to the flange portion 500B.

[0051] The connection hole 501C is provided, penetrating the lid portion 501 from one main surface to the other. This connection hole 501C is connected to the discharge promotion unit (discharge promotion unit 531 in Figure 6, described later). Through this connection hole 501C, a fluid such as air flows from the discharge promotion unit into the containment container 500, and the sample and extractant are discharged from the discharge port 500D.

[0052] The container 500 may be made of a single material or of multiple materials. For example, the container 500 may be made of a resin material. By using a resin material, it is possible to reduce costs and create a container 500 that is suitable for single use. Examples of resins that make up the container 500 include polyethylene, polypropylene, polystyrene, polyvinyl chloride, polycarbonate, polyester, polymethyl methacrylate, polyvinyl acetate, vinyl acetate copolymer, styrene-methyl methacrylate copolymer, acrylonitrile-styrene copolymer, acrylonitrile-butadiene-styrene copolymer, nylon, polymethylpentene, silicone resin, amino resin, polysulfone, polyethersulfone, polyetherimide, fluororesin, and polyimide.

[0053] The collection tool C inserted into the containment container 500 is, for example, made of a cotton swab. Preferably, the collection tool C is disposable and preferably easily incinerated. Easily incinerating the collection tool C helps to suppress the occurrence of infection via the collection tool C. The shaft of the cotton swab is made of, for example, resin, paper, wood, or metal, and the cotton ball is made of absorbent cotton, fiber, or resin. Preferably, the shaft of the cotton swab is made of resin or paper. This makes it easier to use the cotton swab as a disposable item and allows for easy incineration. The cotton ball may have an uneven structure. By providing an uneven structure on the cotton ball, the sample is more easily held within the uneven structure, making it possible to more reliably attach the sample to the collection tool C.

[0054] Using such a sampling device C, a sample is collected, for example, from a mucous membrane area such as the nasal cavity or oral cavity of the subject. The sample is, for example, a bodily fluid collected from a mucous membrane area, specifically, a nasal swab or saliva. The sample may also be a bodily fluid collected from a fluid-moistened area such as a wound. The sample may be collected directly from the subject or indirectly. An indirectly collected sample is, for example, a sample collected from a doorknob touched by the subject. It is preferable that the sample be collected non-invasively from the subject. For example, DNA, RNA, proteins, viruses, or bacteria contained in the sample are tested by reacting with a reagent. The extractant is a liquid capable of extracting the sample collected from the subject by sampling device C, for example, water.

[0055] Figure 5 shows an example of the configuration of the supply mechanism 52. The supply mechanism 52 is a mechanism that allows, for example, an inspector to supply a sampling tool C to a containment container 500 located in the sample receiving section P1. The supply mechanism 52 includes, for example, a locking member 521, a detection unit 522, and a control unit 523. The locking member 521, the detection unit 522, and the control unit 523 are interconnected, for example, via a bus 524.

[0056] The locking member 521 fixes the shielding part 100S in a position that shields the supply part 100M. In other words, the shielding part 100S is configured to be lockable while shielding the supply part 100M. The locking member 521 may mechanically lock the shielding part 100S or it may be electrically locked.

[0057] The detection unit 522 is, for example, a sensor that detects when the containment container holder 51 is located near the supply unit 100M, that is, when it is installed in the sample receiving unit P1. When the detection unit 522 detects that the containment container holder 51 is installed in the sample receiving unit P1, it transmits first detection information to the control unit 523. The detection unit 522 is, for example, a photosensor located near the sample receiving unit P1. The detection unit 522 may also be a sensor that detects the shielding and exposure of the supply unit 100M, that is, the opening and closing of the shielding unit 100S. When the detection unit 522 detects the exposure and shielding of the supply unit 100M in this order, it transmits shielding information to the control unit 523. Here, this detection unit 522 corresponds to one specific example of the first and second detection units of the present invention.

[0058] The control unit 523 has one or more CPUs (Central Processing Units) and executes various processes according to the program. Based on the first detection information sent from the detection unit 522, the control unit 523 releases the locking member 521. This unlocks the shielding unit 100S, allowing the inspector to move the shielding unit 100S. When the detection unit 522 detects that the containment container holding unit 51 has separated from the sample receiving unit P1, the control unit 523, for example, drives the locking member 521 to lock the shielding unit 100S. Based on the shielding information sent from the detection unit 522, the control unit 523 may, for example, display a screen on the display unit for receiving the next instruction from the inspector.

[0059] Figure 6 shows an example of the configuration of the dispensing mechanism 53. The dispensing mechanism 53 is a mechanism for dispensing a sample from a containment container 500 located in the extraction section P2. More specifically, the dispensing mechanism 53 supplies an extractant to the containment container 500 and then dispenses the sample extracted by the extractant to a predetermined location. The dispensing mechanism 53 dispenses the sample below the containment container holding section 51. This dispensing mechanism 53 includes, for example, a dispensing acceleration unit 531, a lid drive unit 532, an extractant supply unit 533, a detection unit 534, and a control unit 535. The dispensing acceleration unit 531, the lid drive unit 532, the extractant supply unit 533, the detection unit 534, and the control unit 535 are interconnected, for example, via a bus 536.

[0060] The discharge promotion unit 531 is responsible for discharging the sample extracted by the extractant in the containment container 500 from the discharge port 500D. For example, the discharge promotion unit 531 includes a pressurizing unit connected to the connection hole 501C of the lid 501 via a joint or the like, and in response to instructions from the control unit 535, it introduces a gas such as air into the containment container 500, which is sealed by the lid 501. This increases the pressure inside the containment container 500, causing the sample extracted by the extractant to be discharged from the discharge port 500D. For example, the discharge amount can be adjusted by controlling the amount of gas introduced into the containment container 500. The discharge promotion unit 531 may also increase the pressure inside the containment container 500 by introducing a liquid into the containment container 500.

[0061] The discharge promotion unit 531 may include, for example, a heating unit for heating the containment container 500, thereby increasing the pressure inside the containment container 500. By heating the containment container 500, the air inside the containment container 500 expands, or the extractant vaporizes, causing the pressure inside the containment container 500 to increase. As a result, the sample extracted by the extractant is discharged from the discharge port 500D of the containment container 500.

[0062] Alternatively, the discharge promotion unit 531 may include a pressing member such as a roller that compresses the containment container 500 from the outside. By compressing the containment container 500 from the outside, the volume inside the containment container 500 decreases and the pressure inside the containment container 500 increases. As a result, the sample extracted in the extractant is discharged from the discharge port 500D of the containment container 500.

[0063] The discharge promotion unit 531 may include a suction unit that applies suction force to the discharge port 500D. The discharge promotion unit 531 including this suction unit applies suction force to the discharge port 500D by creating negative pressure near the discharge port 500D in response to instructions from the control unit 535. As a result, the sample extracted in the extractant is discharged from the discharge port 500D according to the applied suction force.

[0064] The discharge promotion unit 531 may include a vibration unit that vibrates the containment container 500. The discharge promotion unit 531 including this vibration unit vibrates the containment container 500 in response to instructions from the control unit 535. As a result, the pressure inside the containment container 500 changes, and the sample extracted in the extractant is discharged from the discharge port 500D.

[0065] The lid drive unit 532 includes, for example, a lifting member that holds the lid 501 and a drive unit that moves the lifting member vertically. The lid 501 is held by the lifting member, for example, above the retrieval section P2. The lid drive unit 532 lowers the lifting member in response to instructions from the control unit 535. As a result, the insertion opening 500I of the storage container 500 located in the retrieval section P2 is covered by the lid 501, and the storage container 500 is sealed.

[0066] The extractant supply unit 533 includes, for example, an extractant storage unit and an extractant transport unit that transports the extractant from the extractant storage unit into the containment container 500. The extractant storage unit is, for example, a container for storing the extractant, such as water, and the extractant transport unit includes, for example, a pump and pipes. The extractant supply unit 533 supplies the extractant from the extractant storage unit into the containment container 500 in response to instructions from the control unit 535. As a result, the sample attached to the sampling tool C is extracted into the extractant in the containment container 500 located in the extraction unit P2.

[0067] The detection unit 534 is a sensor that detects when the container holder 51 is installed in the removal unit P2. When the detection unit 534 detects that the container holder 51 is installed in the removal unit P2, it transmits second detection information to the control unit 535. The detection unit 534 is, for example, a photosensor located near the removal unit P2. The detection unit 534 may also include a sensor that detects the sealed state of the container 500.

[0068] The control unit 535 has one or more CPUs and performs various processes according to the program. Based on the second detection information sent from the detection unit 534, the control unit 535 first sends an instruction to the extractant supply unit 533 to supply the extractant into the containment container 500. After a predetermined amount of extractant has been supplied to the containment container 500, the control unit 535 sends an instruction to the lid drive unit 532 to lower the lifting member that holds the lid 501. After the containment container 500 is sealed by the lid 501, the control unit 535 instructs the discharge promotion unit 531 to discharge from the discharge port 500D. In response to the instruction from the control unit 535, the discharge promotion unit 531, for example, pressurizes the inside of the containment container 500 and discharges the sample extracted in the extractant from the discharge port 500D of the containment container 500.

[0069] Figures 7 and 8 show an example of the configuration of the waste disposal mechanism 54. The waste disposal mechanism 54 includes, for example, a waste section 540, an extrusion member 541, support members 542A, 542B, and a guide member 543, all located in the waste preparation section P3 (Figure 7). Furthermore, the waste disposal mechanism 54 includes an extrusion member drive unit 544, a detection unit 545, and a control unit 546. The extrusion member drive unit 544, the detection unit 545, and the control unit 546 are interconnected, for example, via a bus 547 (Figure 8).

[0070] The waste section 540 is a collection space for the used container 500 after the sample has been dispensed, and is located below the container holding section 51 (Figure 1). Preferably, the bottom surface of the waste section 540 is sloped. This allows the used container 500 to roll after disposal, making it easier to collect the container 500.

[0071] The extrusion member 541 is positioned below the container holder 51 located in the waste preparation section P3, and is configured to be movable in the vertical direction. The extrusion member 541 is, for example, a plate-shaped member having a rectangular planar shape, and a hole 541H is provided in the center of the extrusion member 541. This hole 541H is, for example, approximately circular in shape and is sized to fit the vicinity of the apex of the conical container 500. When the container holder 51 is placed in the waste preparation section P3, the extrusion member 541 rises, and the hole 541H is fitted into the vicinity of the apex of the container 500 (the lower part of the container 500).

[0072] The support members 542A and 542B are positioned above the container holder 51 located in the waste preparation section P3. That is, when the container holder 51 is located in the waste preparation section P3, the extrusion member 541, the container holder 51, and the support members 542A and 542B are arranged in the waste preparation section P3 from bottom to top in this order. The support members 542A and 542B are, for example, a pair of plate-shaped members facing each other with a guide member 543 in between. The support members 542A and 542B play a role in supporting the container 500 as it rises together with the extrusion member 541. For example, the container 500 is supported when its flange portion 500B comes into contact with the support members 542A and 542B.

[0073] The guide member 543, like the support members 542A and 542B, is positioned above the container holding section 51 located in the waste preparation section P3. This guide member 543 guides the used container 500 to the waste section 540.

[0074] Figure 9 is a perspective view of the guide member 543 shown in Figure 7. The guide member 543 has a guide portion 543G. The guide portion 543G is, for example, composed of an arc-shaped concave surface. As the flange portion 500B of the containment container 500, which rises together with the extrusion member 541, moves in contact with this guide portion 543G, the containment container 500 falls into the waste portion 540.

[0075] The extrusion member drive unit 544 includes a drive unit that moves the extrusion member 541 in the vertical direction. The extrusion member drive unit 544 raises the extrusion member 541 in response to instructions from the control unit 546. As a result, the vicinity of the top of the containment container 500 located in the waste preparation unit P3 is fitted into the hole 541H of the extrusion member 541.

[0076] The detection unit 545 is a sensor that detects when the container holder 51 is installed in the waste preparation unit P3. When the detection unit 545 detects that the container holder 51 is installed in the waste preparation unit P3, it transmits third detection information to the control unit 546. The detection unit 545 is, for example, a photosensor located near the waste preparation unit P3.

[0077] The control unit 546 has one or more CPUs and performs various processes according to the program. Based on the third detection information sent from the detection unit 545, the control unit 546 sends an instruction to the extrusion member drive unit 544 to raise the extrusion member 541. As a result, the used container 500 that has been raised together with the extrusion member 541 is guided to the waste unit 540.

[0078] Figures 10 and 11 show an example of the configuration of the standby mechanism 55. The standby mechanism 55 includes, for example, a standby unit 550 and rotating members 551A and 551B provided on the installation unit P4 (Figure 10). Furthermore, the standby mechanism 55 includes a rotating member drive unit 552, a detection unit 553, and a control unit 554. The rotating member drive unit 552, the detection unit 553, and the control unit 554 are interconnected, for example, via a bus 555 (Figure 11).

[0079] The standby section 550 is a waiting space for empty containers 500 before samples are supplied, i.e., before use, and is located above the container holder 51 which is placed in the installation section P4. The standby section 550 is located between a pair of rotating members 551A and 551B. For example, multiple containers 500 are stacked in the standby section 550.

[0080] The pair of rotating members 551A and 551B have, for example, a substantially circular planar shape and are configured to be rotatable within this plane. For example, rotating member 551A rotates counterclockwise, and rotating member 551B rotates clockwise. Each of the rotating members 551A and 551B has a plurality of recesses 551R provided along its circumference. The flange portion 500B of the storage container 500 fits into the recesses 551R of each of the rotating members 551A and 551B, thereby holding the storage container 500 in the standby section 550. For example, by inserting another storage container 500 into the insertion opening 500I of the storage container 500 held by the rotating members 551A and 551B, a plurality of storage containers 500 are held in the standby section 550.

[0081] The rotating member drive unit 552 includes a drive unit that rotates the rotating members 551A and 551B. The rotating member drive unit 552 rotates the rotating members 551A and 551B in response to instructions from the control unit 554. As a result, the flange portion 500B that was fitted into the recess 551R of the rotating members 551A and 551B is ejected, and the storage container 500 that was held by the rotating members 551A and 551B falls. At this time, the flange portion 500B of another storage container 500 fits into the recess 551R and is held between the rotating members 551A and 551B.

[0082] The detection unit 553 is a sensor that detects when the container holder 51 is installed in the installation area P4. When the detection unit 553 detects that the container holder 51 is installed in the installation area P4, it transmits fourth detection information to the control unit 554. The detection unit 553 is, for example, a photosensor located near the installation area P4.

[0083] The control unit 554 has one or more CPUs and executes various processes according to the program. Based on the fourth detection information sent from the detection unit 553, the control unit 554 sends an instruction to the rotating member drive unit 552 to rotate the rotating members 551A and 551B. As a result, the empty storage container 500 falls from the standby unit 550 into the storage container holding unit 51. The flange portion 500B of the fallen storage container 500 widens from the hole portion 51H, and the storage container 500 is held in the storage container holding unit 51.

[0084] Figure 12 shows an example of the configuration of the displacement mechanism 56. The displacement mechanism 56 includes, for example, a support drive unit 561, a receiving unit 562, and a control unit 563. The support drive unit 561, the receiving unit 562, and the control unit 563 are interconnected, for example, via a bus 564.

[0085] The support unit drive unit 561 includes a drive unit that rotates the support unit 511 axially. The support unit drive unit 561 rotates the support unit 511 axially in response to instructions from the control unit 563. As a result, the container holding unit 51 supported by the support unit 511 rotates and is displaced between the sample receiving unit P1, the removal unit P2, the disposal preparation unit P3, and the installation unit P4.

[0086] The reception unit 562 is composed of, for example, a touch panel that receives instructions from the inspector. The inspector inputs instructions to proceed with each step of the process into the reception unit 562. When the reception unit 562 receives the instructions from the inspector, it transmits the instruction information to the control unit 563.

[0087] The control unit 563 has one or more CPUs and executes various processes according to the program. Based on instruction information sent from the reception unit 562, the control unit 563 sends instructions to the support unit drive unit 561 to displace the containment container holding unit 51. For example, when the instruction to start the inspection is received from the inspector, the containment container holding unit 51 is displaced from the disposal preparation unit P3 to the installation unit P4. When the instruction to start the inspection is received from the inspector, the containment container holding unit 51 may be displaced from the installation unit P4 to the sample receiving unit P1.

[0088] <Operation of extraction device 50> Figure 13 is a flowchart illustrating an example of the operation flow of the extraction device 50. The extraction device 50 operates, for example, as follows:

[0089] First, when the reception unit 562 receives an instruction from the inspector to start the inspection, the displacement mechanism 56 positions the container holder 51 in the installation unit P4 (step S101). Next, the standby mechanism 55 rotates the rotating members 551A and 551B (step S102). As a result, the empty container 500 falls from the standby unit 550 into the hole 51H and is held in the container holder 51.

[0090] Next, when the reception unit 562 receives instructions from the inspector, the displacement mechanism 56 positions the containment container holding unit 51 in the sample receiving unit P1 (step S103). Subsequently, the supply mechanism 52 unlocks the shielding unit 100S (step S104). This allows the inspector to move the shielding unit 100S and expose the supply unit 100M. The inspector inserts the sample collection tool C, to which the sample has been attached, into the containment container 500 via the supply unit 100M. After this, the inspector moves the shielding unit 100S to shield the supply unit 100M.

[0091] Next, when the reception unit 562 receives instructions from the inspector, the displacement mechanism 56 places the container holder 51 into the removal unit P2 (step S105). At this time, the supply mechanism 52 locks the shielding unit 100S (step S106). The supply mechanism 52 may lock the shielding unit 100S before the container holder 51 is placed into the removal unit P2.

[0092] Next, the dispensing mechanism 53 supplies the extractant to the containment container 500 located in the outlet P2 (step S107). After this, the dispensing mechanism 53 lowers the lid 501 (step S108). This seals the containment container 500. Next, the dispensing mechanism 53 introduces air into the sealed containment container 500, for example. This causes the sample extracted by the extractant to be discharged from the discharge port 500D of the containment container 500 to a predetermined location (step S109). The sample discharged from the discharge port 500D is then mixed with a reagent, for example, at a predetermined location.

[0093] Next, when the reception unit 562 receives instructions from the inspector, the displacement mechanism 56 positions the container holding unit 51 in the disposal preparation unit P3 (step S110). After this, the disposal mechanism 54 raises the extrusion member 541 (step S111). As a result, the vicinity of the top of the container 500 fits into the hole 541H of the extrusion member 541, and the container 500, which has risen together with the extrusion member 541, is guided to the disposal unit 540 by the guide member 543. For example, the extraction device 50 operates in this manner.

[0094] <Effects of the extraction device 50> In the extraction apparatus 50 of this embodiment, a supply unit 100M is provided for supplying a sample to a containment container 500 inside the housing 100 from outside the housing 100. More specifically, the supply unit 100M is provided at a position corresponding to the insertion opening 500I of the containment container 500 located in the sample receiving unit P1. This allows the person performing the test to supply a sample to the containment container 500 from outside the housing 100 without touching the containment container 500. Therefore, it is possible to reduce contamination of the containment container 500 caused by the test performer, who is unfamiliar with handling samples, touching the containment container 500.

[0095] Furthermore, in the extraction device 50, the sample is dispensed from the containment container 500 at the extraction section P2, eliminating the need for pipetting or other operations. This allows the biological sample extracted with the extractant to be removed to a designated location with fewer steps. Therefore, even a tester unfamiliar with handling samples can easily remove the sample.

[0096] Furthermore, the container holding unit 51 is configured to be positioned in the disposal preparation unit P3, and the extraction device 50 is equipped with a disposal mechanism 54. Therefore, in the disposal preparation unit P3, the used containers 500 held in the container holding unit 51 are guided to the disposal unit 540. This allows the person performing the test to dispose of the used containers 500 without touching them. Thus, it is possible to reduce the risk of infection caused by a person performing the test who is unfamiliar with handling samples touching the used containers 500.

[0097] Furthermore, the extraction device 50 includes a supply mechanism 52, a discharge mechanism 53, a disposal mechanism 54, a standby mechanism 55, and a displacement mechanism 56. This allows the inspector to place an empty container 500 into the container holder 51, supply a sample to the container 500, discharge the sample from the container 500, and dispose of the used container 500 without touching the container 500. Therefore, even an inspector unfamiliar with handling samples can perform inspections with high accuracy and safety.

[0098] <Configuration of inspection device 60> Figures 14 and 15 show the schematic configuration of the inspection device 60. Figure 14 shows the configuration of the side view (XZ plane) of the inspection device 60, and Figure 15 shows the configuration of the top view (XY plane) of the inspection device 60.

[0099] The inspection device 60 is a device for performing optical measurements of a sample and reagent mixture. The inspection device 60 has a shaft 11, a support base 12, a detection unit 13, a reagent supply unit 15, an optical measurement unit 16, a holding base 17, and a waste liquid storage unit 19.

[0100] In the inspection system 1, a support base 12 and a detection unit 13 are provided on the shaft 11 in that order. A holding base 17 is positioned above the support base 12, and the reagent supply unit 15 and the optical measurement unit 16 are held on this holding base 17. The waste liquid storage unit 19 is located below the support base 12. The extractant storage unit of the extraction device 50 may also be held on the holding base 17.

[0101] The shaft portion 11 has, from bottom to top, a rotating shaft 11a, a connecting portion 11b, and a rotating shaft 11c. For example, the rotating shaft 11a is connected to a motor (not shown) and rotates axially. The connecting portion 11b connects the rotating shaft 11c to the rotating shaft 11a on the same axis. The rotating shaft 11c rotates axially in conjunction with the rotation of the rotating shaft 11a.

[0102] The support base 12, which is mounted on the rotation axis 11c, has a rotation surface 12s (XY plane) that is substantially perpendicular to the rotation axes 11a and 11c. The rotation surface 12s has, for example, a circular planar shape (Figure 2). The support base 12 is a so-called turntable, and the rotation surface 12s rotates clockwise or counterclockwise in the XY plane as the rotation axes 11a and 11c rotate. A detection unit 13 is provided on this rotation surface 12s, and the detection unit 13 is displaced as the rotation surface 12s rotates. For example, one detection unit 13 is provided on the rotation surface 12s. Multiple detection units 13 may be provided on the rotation surface 12s. The extraction unit P2 of the extraction device 50 is positioned opposite the support base 12.

[0103] The detection unit 13, supported by the support base 12, receives reagents from the reagent supply unit 15 and samples from the containment container 500. Light is then shone onto the detection unit 13, which is supplied with the reagents and samples, from the optical measurement unit 16.

[0104] Figures 16(A) and 16(B) show an example of the configuration of the detection unit 13. Figure 16(A) shows the configuration of the side surface (XZ plane) of the detection unit 13, and Figure 16(B) shows the configuration of the top surface (XY plane) of the detection unit 13. The detection unit 13 has a laminated structure of an opaque member 131 and a transparent member 132, in that order from the rotating surface 12s side. A receiving portion 21 is provided on the detection unit 13.

[0105] The opaque member 131 is, for example, a plate-shaped member having a rectangular planar shape. The opaque member 131 is made of a material that has low transmittance to light irradiated from the optical measuring unit 16. The opaque member 131 includes, for example, single-crystal silicon (Si) material or resin material.

[0106] The transparent member 132 is laminated on the opaque member 131 and, for example, has substantially the same planar shape as the opaque member 131. The transparent member 132 is provided with a channel 132f through which a liquid containing reagents and samples flows. This channel 132f allows the liquid containing reagents and samples to flow, for example, along the long side of the transparent member 132. The channel 132f has a widened section 132fb that is wider than the width of the other parts of the channel 132f. The widened section 132fb is provided, for example, in the center of the channel 132f. For example, light is irradiated from the optical measuring unit 16 onto the sample and reagents stored in this widened section 132fb, and their optical properties are measured. The side of the channel 132f facing the optical measuring unit 16 may be open.

[0107] The transparent member 132 is made of a material that has high transmittance to light irradiated from the optical measuring unit 16, and the light irradiated from the optical measuring unit 16 reaches the widened portion 132fb. The transparent member 132 includes, for example, a glass material or a resin material. The glass material included in the transparent member 132 is, for example, silica glass, and by constructing the transparent member 132 using such a glass material, high light transmittance can be achieved. The resin material included in the transparent member 132 is, for example, dimethylpolysiloxane, polystyrene, polycarbonate, cycloolefin, and acrylic. Dimethylpolysiloxane has high transferability to molds, and the transparent member 132 can be easily formed. By using polystyrene, polycarbonate, cycloolefin, and acrylic, the transparent member 132 can be mass-produced by injection molding. Furthermore, by forming the transparent member 132 using polystyrene and cycloolefin, which have low autofluorescence, noise in optical measurements can be reduced. By forming the transparent member 132 using polycarbonate with a high refractive index, the inspection system 1 can be miniaturized. By forming the transparent member 132 using acrylic with high light transmittance, it is possible to suppress the attenuation of light during light guidance and improve the accuracy of optical measurement. The light incident surface of the transparent member 132 is preferably optically smooth. This improves the accuracy of measurement by the optical measurement unit 16. The thickness of the transparent member 132 is not particularly limited and can be adjusted considering rigidity, light transmittance, etc.

[0108] The receiving portion 21 on the transparent member 132 is responsible for receiving the sample supplied from the containment container 500 and the reagent supplied from the reagent supply unit 15 at the top of the detection unit 13 and directing them into the flow path 132f of the detection unit 13 (more specifically, the transparent member 132). The receiving portion 21 has, for example, a funnel shape, and one opening of the receiving portion 21 widens as it moves away from the transparent member 132. The other opening of the receiving portion 21 communicates with the flow path 132f. The sample and reagent are mixed in the receiving portion 21, for example, before being directed into the flow path 132f. For example, the receiving portion 21 is vibrated by bringing an excitation mechanism into contact with the outside of the receiving portion 21, thereby mixing the sample and reagent in the receiving portion 21. Alternatively, the sample and reagent may be mixed within the flow path 132f. For example, by drawing air into the channel 132f from one end and pumping the channel 132f, the gas and liquid in the channel 132f move, and the sample and reagent are mixed within the channel 132f.

[0109] The reagent supply unit 15 is held on a holding stand 17. This reagent supply unit 15 stores a predetermined amount of reagent, and the reagent stored in the reagent supply unit 15 is supplied to the detection unit 13. The reagent supply unit 15 stores, for example, reagents dispersed or dissolved in a solvent. The reagent supply unit 15 has, for example, a substantially cylindrical shape, and a discharge port 15d is provided at its lower end. The discharge port 15d is positioned, for example, opposite the rotating surface 12s. The reagent stored in the reagent supply unit 15 is supplied to the detection unit 13 via the discharge port 15d. Figure 5 shows an example in which the testing system 1 has two reagent supply units 15, but the testing system 1 may have one reagent supply unit 15, or it may have three or more reagent supply units 15.

[0110] The reagents stored in the reagent supply unit 15 are, for example, dyes, fluorescent substances, and nanoparticles, which form physical or chemical bonds with the target substance contained in the sample. Known reagents can be used for this purpose. Fluorescent substances are, for example, fluorescent dyes or quantum dots. Nanoparticles are, for example, polystyrene beads or gold nanoparticles. For example, by binding such reagents to the target substance, the optical signal generated during light irradiation is increased, making it easier to detect the target substance. Such reagents are particularly effective when the optical signal of the target substance alone is weak. The reagents may also be substances that cause light absorption or light scattering. In this case, by binding the reagents to the target substance, the light intensity generated during light irradiation decreases, and the optical signal is amplified.

[0111] The binding of reagents to target substances can take various forms, such as physical adsorption, antigen-antibody reactions, DNA hybridization, biotin-avidin bonding, chelation, or amino bonding. Physical adsorption binding, for example, utilizes electrostatic bonding forces, such as hydrogen bonding. Physical adsorption binding eliminates the need for sample pretreatment and allows for easy generation of reagent-target substance conjugates. Antigen-antibody reactions involve specific binding between target substances, such as viruses, and reagents, suppressing noise generated by impurities other than the target substance in the sample. When detecting target substances using antigen-antibody reactions, for example, reagents conjugated with antibodies are prepared in advance.

[0112] The extraction unit P2 and reagent supply unit 15 of the extraction device 50 are arranged along the direction in which the detection unit 13 is displaced, i.e., along the rotational direction of the rotational surface 12s. For example, the extraction unit P2, reagent supply unit 15, and optical measurement unit 16 are arranged in this order counterclockwise (Figure 15). The extraction unit P2, reagent supply unit 15, and optical measurement unit 16 may also be arranged in this order clockwise. The extraction unit P2, reagent supply unit 15, and optical measurement unit 16 may be arranged in the order of reagent supply unit 15, extraction unit P2, and optical measurement unit 16, either counterclockwise or clockwise.

[0113] The optical measuring unit 16 is held on a holding stage 17, for example, together with the reagent supply unit 15, and measures the optical properties of the sample and reagent supplied to the detection unit 13. This optical measuring unit 16 is positioned above the rotating surface 12s, and the detection unit 13 can be positioned opposite the optical measuring unit 16, i.e., directly below the optical measuring unit 16. The presence or content of the target substance contained in the sample is detected from the measurement results of the optical measuring unit 16.

[0114] The optical measuring unit 16, for example, irradiates the detection unit 13 with light and detects the optical signal generated by the detection unit 13. The optical measuring unit 16 includes, for example, an irradiating unit and a light receiving unit. The irradiating unit and the light receiving unit are, for example, positioned opposite the rotating surface 12s.

[0115] The irradiation unit includes a light source and irradiates light from the light source toward the detection unit 13. The light irradiated from the irradiation unit toward the detection unit 13 is, for example, light in a wavelength range capable of exciting a fluorescent substance. The light source is, for example, a lamp, an LED (Light Emitting Diode), or a laser. The light generated by the light source may be monochromatic light or light having a broad wavelength band. When the light generated by the light source has a broad wavelength band, it is preferable that the irradiation unit has an optical filter such as a bandpass filter. When a lamp or LED is used as the light source, it is preferable that the irradiation unit includes a guide member that restricts the direction of propagation of the light generated by the light source. The guide member is, for example, a collimating lens.

[0116] The light-receiving unit includes, for example, an imaging device such as a photodiode, photodetector, CCD (Charge Coupled Device) image sensor, and CMOS (Complementarily Metal Oxide Semiconductor) image sensor. The photodetector is, for example, a photomultiplier tube. Known imaging devices can be used in the light-receiving unit. This light-receiving unit detects the light intensity or spectrum of light incident on the optical measurement unit 16. The light-receiving unit may detect the intensity of light of a single wavelength or the intensity of light of multiple wavelengths. When light irradiated from the irradiation unit is incident on the detection unit 13, for example, this light excites a compound of the reagent and the substance to be detected, generating an optical signal. The generated optical signal is incident on the light-receiving unit either directly or reflected at the interface between the transparent member 132 and the opaque member 131.

[0117] The holder 17, which holds the reagent supply unit 15 and the optical measurement unit 16, is positioned above the support base 12, and a portion of the holder 17 faces the support base 12. A reagent holding section 172 is provided on the upper surface of this holder 17.

[0118] The reagent holder 172 is fixed to the upper surface of the holder base 17. The reagent holder 172 has, for example, a ring shape, and the reagent supply unit 15 is held inside the reagent holder 172. The reagent supply unit 15 is configured to be detachable from the reagent holder 172.

[0119] A waste liquid reservoir 19 located at the bottom of the support base 12 stores waste liquid generated, for example, when cleaning the detection unit 13. For example, after measuring the optical properties of a mixture of sample and reagent supplied to the detection unit 13, a cleaning solution is supplied to the detection unit 13. The cleaning solution is supplied to the detection unit 13, for example, via a receiving unit 21. The sample and reagent in the flow path 132f are discharged into the waste liquid reservoir 19 along with the cleaning solution supplied to the detection unit 13. The waste liquid is discharged into the waste liquid reservoir 19, for example, by suctioning one end of the flow path 132f. In this way, the detection unit 13 can be reused by cleaning it after measuring its optical properties. A cleaning solution supply unit (not shown) where the cleaning solution is stored may be located at the bottom of the support base 12.

[0120] <Inspection method using inspection system 1> The inspection method using the inspection system 1 of this embodiment will be described below with reference to Figure 17. Figure 17 is a flowchart showing an example of an inspection method using the inspection system 1.

[0121] First, the person performing the test collects a sample from the subject using collection tool C, etc. (Step S201). Specifically, the person performing the test uses collection tool C to swab saliva or nasal fluid from the subject's pharynx or nasal cavity, etc. The person performing the test may be the subject themselves.

[0122] Next, the examiner inserts the sample collection tool C, to which the subject's sample is attached, into the containment container 500 via the supply unit 100M (step S202). After this, the examiner shields the supply unit 100M with the shielding unit 100S and inputs instructions to the reception unit 562, at which point the containment container holding unit 51 is displaced from the sample receiving unit P1 to the removal unit P2.

[0123] In the extraction section P2, the dispensing mechanism 53 of the extraction device 50 supplies the extractant to the containment container 500 (step S203), and then the sample extracted by the extractant is discharged from the discharge port 500D (step S204). This supplies the sample to the detection section 13.

[0124] Next, the test operator rotates the rotating surface 12s to position the detection unit 13 directly below the reagent supply port 15M, and then supplies a specified amount of reagent from the reagent supply unit 15 to the detection unit 13 via the reagent supply port 15M (step S205).

[0125] Next, the inspector mixes the sample and reagent supplied to the detection unit 13 (step S206). For example, the inspector mixes the sample and reagent by moving the liquid back and forth within the flow path 132f. This creates a compound between the reagent and the target substance contained in the sample.

[0126] Next, the inspector rotates the rotating surface 12s to position the detection unit 13 directly below the optical measurement unit 16 (step S207), and performs optical measurement of the mixed sample and reagents (step S208). In the optical measurement, the optical measurement unit 16 irradiates light toward the detection unit 13 and receives light incident on the optical measurement unit 16 from the detection unit 13 side.

[0127] The inspector performs optical measurement on the detection unit 13 and then outputs the results of the optical measurement (step S209). The results of the optical measurement are then identified and output, for example, by image processing.

[0128] Next, the inspector cleans the detection unit 13 (step S210). The detection unit 13 is cleaned, for example, as follows: First, the rotating surface 12s is rotated to displace the detection unit 13 directly above the cleaning fluid supply unit, and cleaning fluid is supplied from the cleaning fluid supply unit to the detection unit 13. Next, the sample and reagents in the flow path 132f are discharged into the waste liquid storage unit 19 along with the supplied cleaning fluid. Discharge into the waste liquid storage unit 19 may be performed after displacing the detection unit 13 directly above the waste liquid storage unit 19. Subsequently, the rotating surface 12s is rotated to displace the detection unit 13 directly below the optical measurement unit 16, and optical measurement of the detection unit 13 is performed. After this, the results of the optical measurement are output, and once it is confirmed that the detection unit 13 has been cleaned, the cleaning is terminated. If the detection unit 13 is not sufficiently cleaned, the supply and discharge of cleaning fluid to the detection unit 13 is repeated.

[0129] After cleaning the detection unit 13, the detection process is terminated. Alternatively, after cleaning the detection unit 13, the process may return to step S101.

[0130] In this testing system 1, since an extraction device 50 is used, the person performing the test can supply the sample extracted in the extractant to the detection unit 13 without touching the containment container 500. Therefore, it is possible to reduce contamination of the containment container 500 caused by the test performer, who may be unfamiliar with handling samples, touching the containment container 500. Such a testing system 1 can be easily performed by the subject themselves, and can be used for purposes other than medical treatment. Examples of uses other than medical treatment include inspections for permission to enter buildings, etc.

[0131] Furthermore, in this inspection system 1, the discharge port 500D and the reagent supply port 15M can be positioned above the rotating surface 12s. Therefore, by placing the detection unit 13 on the rotating surface 12s and rotating the rotating surface 12s, the detection unit 13 is displaced directly below the discharge port 500D and the reagent supply port 15M, respectively. Thus, the sample and reagent can be supplied to the detection unit 13 from the discharge port 500D and the reagent supply port 15M with simple operation.

[0132] The following describes modified versions of the extraction apparatus 50 described in the above embodiment. In order to avoid repetition, detailed explanations of configurations similar to those of the extraction apparatus 50 described in the above embodiment will be omitted below.

[0133] (modified version) Figure 18 shows the configuration of the supply mechanism 52 of the extraction device 50 according to a modified example. The supply mechanism 52 includes, for example, a shielding unit drive unit 525, a detection unit 526, and a control unit 527. The shielding unit drive unit 525, the detection unit 526, and the control unit 527 are interconnected, for example, via a bus 528.

[0134] The shielding drive unit 525 drives the shielding unit 100S to shield and expose the supply unit 100M. For example, the shielding unit 100S is configured to be slidable, and the shielding drive unit 525 shields and exposes the supply unit 100M by sliding the shielding unit 100S.

[0135] The detection unit 526 is a sensor that detects a person or object within a predetermined range from the supply unit 100M. When the detection unit 526 detects that a person or a sampling tool C, etc., has approached the vicinity of the supply unit 100M, it transmits fifth detection information to the control unit 527. The detection unit 526 is, for example, a human presence sensor located near the supply unit 100M. The detection unit 526 may also be a camera, etc. Here, this detection unit 526 corresponds to one specific example of the third detection unit of the present invention.

[0136] The control unit 527 has one or more CPUs and performs various processes according to the program. Based on the fifth detection information sent from the detection unit 526, the control unit 527 sends an instruction to the shielding unit drive unit 525 to expose the supply unit 100M. This allows the inspector to insert the sampling tool C into the containment container 500 through the exposed supply unit 100M. For example, if the control unit 527 determines, based on information sent from the detection unit 526, that there is no person or object within a predetermined range from the supply unit 100M, it sends an instruction to the shielding unit drive unit 525 to shield the supply unit 100M.

[0137] In this extraction device 50 having such a supply mechanism 52, the containment container holding section 51 is configured to be positioned in the sample receiving section P1, similar to the embodiment described above, and the supply section 100M of the housing 100 is provided in the part corresponding to the sample receiving section P1. Therefore, it is possible to reduce contamination of the containment container 500 caused by an inexperienced tester touching the containment container 500. Furthermore, in this extraction device 50, the supply section 100M is shielded and exposed without the tester touching the shielding section 100S, thus suppressing the occurrence of infection via the shielding section 100S.

[0138] As described above, the extraction apparatus and inspection system of the present invention have been explained in embodiments. However, it goes without saying that the present invention can be appropriately added to, modified, and omitted by those skilled in the art within the scope of its technical concept.

[0139] For example, the control units 523, 535, 546, 554, and 563 described in the above embodiment may be composed of a single CPU, and the detection units 522, 534, 545, and 553 may be composed of a single sensor.

[0140] Furthermore, in the above embodiment, an example was described in which the container holding unit 51 is displaced to each position by the inspector inputting instructions via the reception unit 562. However, the extraction device 50 may also be configured to displace the container holding unit 51 when it detects the completion of each operation in the sample receiving unit P1, the removal unit P2, the disposal preparation unit P3, and the installation unit P4.

[0141] Furthermore, although the above embodiment describes an example in which the sample is dispensed from the containment container 500 and then removed at the removal unit P2, the sample may also be removed at the removal unit P2 by drawing up the sample from the containment container 500 using a pipette or the like.

[0142] Furthermore, although the above embodiment describes an example in which the sample attached to the collection tool C is supplied to the containment container 500, the sample may also be supplied directly to the containment container 500. In addition, the extraction unit P2 may be configured to extract the sample from the containment container 500 without supplying the extraction agent to the containment container 500.

[0143] Furthermore, although the above embodiment describes an example where the sample is a sample taken from a living organism, the sample may be a sample other than a living organism, such as wastewater.

[0144] Furthermore, although the above embodiment describes an example in which the sample receiving section P1, the removal section P2, the waste preparation section P3, and the installation section P4 are arranged in different positions within the housing 100, some or all of these may be arranged in the same position within the housing 100.

[0145] Furthermore, although the above embodiment describes an example in which the storage container 500 is held in the storage container holding part 51 within the housing 100, the storage container 500 may be held within the housing 100 while moving from the storage container holding part 51 to other members, or from other members to the storage container holding part 51.

[0146] Furthermore, although the above embodiment describes an example in which the detection unit 13 is cleaned after optical measurement and reused, it is also possible to replace the detection unit 13 with a new one each time optical measurement is performed. In this case, the inspection device does not need to be provided with a waste liquid storage unit.

[0147] Furthermore, although the above embodiment describes an example in which both the irradiation unit and the light receiving unit of the optical measuring unit 16 are provided on the upper part of the rotating surface 12s, the irradiation unit and the light receiving unit of the optical measuring unit 16 may be provided in other positions. For example, the irradiation unit may be provided on the upper part of the rotating surface 12s and the light receiving unit may be provided on the lower part of the rotating surface 12s.

[0148] Furthermore, although the above embodiment describes an example where the sample is saliva or nasal swab, the sample may be anything containing the substance to be detected, such as blood and urine. In addition, the extraction device 50 may extract substances other than the sample, such as chemicals, environmental water, tap water, and sewage.

[0149] Furthermore, the operation of the extraction device 50 and the inspection method of the inspection system 1 described above may include steps other than those in the flowchart above, or may omit some of the steps described above. Also, the order of the steps is not limited to the embodiments described above. [Explanation of Symbols]

[0150] 1. Inspection system, 11. Shaft section, 12 support platform; 12s rotation surface, 13 Detection unit, 131 Opaque material, 132 Transparent material, 132f channel, 15 Reagent supply unit, 15M reagent supply port, 16 Optical measurement section, 17 Holding stand; 172 Reagent holding section, 19. Wastewater storage section, 21 Receiving part, 50 extraction equipment, 51 Container holding section, 52 supply mechanism, 53 Discharge mechanism, 54. Disposal mechanism, 55 Standby mechanism; 56 Displacement mechanism, 500 container.

Claims

1. A sample extraction device for extracting a sample contained in a container, A container holding unit is configured to hold the container and to be positioned in an outlet from which the sample contained in the container is removed from the container, A housing that covers the container holding portion and the removal portion. Equipped with, The housing is provided with an opening for supplying the sample from outside the housing to the container inside the housing, A sample retrieval device wherein the container holding section is configured to be further arranged into a sample receiving section for supplying the sample to the container, an installation section for placing an empty container in the container holding section, and a disposal preparation section for disposing of the container from the container holding section to a disposal section.

2. The sample extraction device according to claim 1, wherein the waste disposal section is provided below the container holding section.

3. The sample extraction device according to claim 1 or 2, further comprising a waste mechanism for guiding the containment container to the waste section.

4. The aforementioned waste disposal mechanism is An extrusion member is configured to be movable in the vertical direction and to push up the container positioned in the waste preparation section, A guide member that guides the container, which has been pushed up by the extrusion member, to the waste section. The sample extraction apparatus according to claim 3, including the following:

5. The sample extraction device according to any one of claims 1 to 4, further comprising a displacement mechanism that positions the container holding portion between the sample receiving portion and the extraction portion.

6. The aforementioned container holding portion further has a support portion that rotatably supports it, The sample extraction device according to claim 5, wherein the displacement mechanism includes a drive unit for axially rotating the support unit.

7. A sample extraction device for extracting a sample contained in a container, A container holding unit is configured to hold the container and to be positioned in an outlet from which the sample contained in the container is removed from the container, A housing that covers the container holding portion and the removal portion, A pair of rotating members that are rotatably held and have recesses that engage with flanges provided on the container, Equipped with, The housing is provided with an opening for supplying the sample from outside the housing to the container inside the housing, A sample retrieval device comprising a waiting section for holding an empty container between the pair of rotating members.

8. The sample extraction device according to claim 7, wherein the standby unit is provided above the container holding unit.

9. The sample extraction device according to any one of claims 1 to 8, further comprising a dispensing mechanism for extracting the sample by dispensing the sample from the containment container arranged in the extraction section.

10. The sample extraction device according to claim 9, wherein the discharge mechanism includes a discharge promoting unit that discharges the sample from the containment container by increasing the pressure inside the containment container.

11. The sample extraction device according to any one of claims 1 to 10, further comprising a shielding portion capable of shielding the aforementioned opening.

12. The sample extraction device according to claim 11, further comprising a locking member for fixing the shielding portion in a position that shields the opening.

13. The sample extraction device according to claim 11 or 12, further comprising a first detection unit for detecting the shielding and exposure of the opening by the shielding unit.

14. The sample extraction device according to any one of claims 1 to 13, further comprising a second detection unit for detecting that the container holding unit is positioned close to the opening.

15. The sample extraction device according to any one of claims 1 to 14, further comprising a third detection unit for detecting a person or object present within a predetermined range from the opening.

16. The sample extraction device according to any one of claims 1 to 15, wherein the opening is configured to allow the sampling tool to which the sample is attached to be received from outside the housing.

17. The sample extraction device according to any one of claims 1 to 16, further comprising an extractant supply unit for supplying an extractant to the containment container arranged in the extraction unit.

18. The sample extraction apparatus according to claim 17, wherein the extractant supply unit includes an extractant storage unit for storing the extractant and an extractant transport unit for transporting the extractant stored in the extractant storage unit into the containment container.

19. The sample extraction device according to any one of claims 1 to 18, wherein one of the containers is held in the container holding section.

20. A sample extraction device according to any one of claims 1 to 19, A detection unit that receives the sample removed in the extraction unit, A reagent supply unit that supplies reagents to the detection unit, An optical measuring unit that measures the optical properties of the sample and reagent supplied to the detection unit. An inspection system equipped with the following features.

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