Method for optimizing the sampling trajectory in molecular exchange magnetic resonance measurements, molecular exchange magnetic resonance measurement method and apparatus

Abstract

The present invention discloses a method for optimizing the sampling trajectory of a molecular exchange magnetic resonance (MEL) measurement. The method includes the steps of: (1) determining the number and corresponding range of physiological / physical parameters of a molecular exchange system and generating a simulated physiological / physical parameter dataset; (2) determining a molecular exchange magnetic resonance measurement method and setting the acquisition parameters; (3) constructing an end-to-end integrated network model including a sampling trajectory optimization network, a noise signal generation network, and a parameter estimation network; and (4) training the network using the simulated physiological / physical parameters as input, and obtaining the optimized sampling trajectory and the corresponding parameter estimation network once the network has converged and training is complete. The present invention further discloses a molecular exchange magnetic resonance measurement method and apparatus. The method for optimizing the sampling trajectory of a molecular exchange magnetic resonance measurement provided by the present invention improves the efficiency and accuracy of physiological / physical parameter estimation and can be applied to various molecular exchange magnetic resonance measurement methods.

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