High Ionic Intensity Dissociation Assay for Advanced Drug Resistance Testing

JP7883820B2Active Publication Date: 2026-07-02F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Filing Date
2021-05-06
Publication Date
2026-07-02

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Abstract

Reported herein is a method for determining the presence of an anti-drug antibody in a sample, comprising the steps of incubating the sample with MgCl2 at a final concentration ranging from 1N to 12N; adding a tracer antibody and then incubating the sample; incubating the isolated tracer antibody-anti-drug antibody complex with a detection antibody conjugated to a detectable label; and determining the presence of the anti-drug antibody if a signal above a threshold level is obtained. TIFF2023524561000009.tif82170
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