Method for synthesizing high-purity Nε-lauroyllysine
The two-phase microemulsion reaction system addresses low selectivity in Nε-lauroyllysine synthesis by selectively reacting lauric acid with the ε-amino group, achieving high purity and facilitating industrial production.
JP7891296B2Active Publication Date: 2026-07-16CHANGSHA PUJI BIOTECH
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Patents
- Current Assignee / Owner
- CHANGSHA PUJI BIOTECH
- Filing Date
- 2024-08-07
- Publication Date
- 2026-07-16
AI Technical Summary
Technical Problem
Existing methods for synthesizing Nε-lauroyllysine suffer from low reaction selectivity, leading to the formation of byproducts and difficulty in separation and purification, making them unsuitable for industrial production.
Method used
A two-phase microemulsion reaction system is employed, where the α-amino group and carboxyl group are concentrated in the aqueous phase and the ε-amino group in the oil phase, allowing lauric acid or lauroyl halide to react selectively at the oil-water interface, thereby enhancing reaction selectivity and purity.
Benefits of technology
The method achieves high-purity Nε-lauroyllysine with purities over 92%, reducing side reactions and enabling easy separation and purification, suitable for industrial-scale production.
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Abstract
This invention uses high-purity N ε This invention discloses a method for synthesizing lauroyl lysine, which belongs to the technical field of precision synthesis. The method comprises uniformly stirring raw materials including lysine and / or lysine salt, a basic compound, water, a lower alcohol, and a non-aqueous solvent to form a two-phase microemulsion, adding lauric acid and / or lauroyl halide dropwise to the two-phase microemulsion and stirring to react, and after the reaction is completed, precipitating the product by acid neutralization to obtain N-lauroyl lysine. ε This method cleverly solves the problem of reaction selectivity between α-amino and ε-amino groups by constructing a two-phase reaction system, and produces high-purity N-lauroyl lysine in high yield. ε -Lauroyl lysine can be obtained, and the reaction conditions are mild, and the product can be easily separated and purified, making it suitable for industrial production.
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