Biological particle sorting device, biological particle sorting system, and information processing device

Abstract

The main purpose of the present disclosure is to enhance the operability of a bioparticle sorting device, and in particular, to enhance the operability of a user interface of the device.　Provided is a bioparticle sorting device which has a display unit that displays a measurement data display area, and which, in a display mode in which a blank space in addition to one or more pieces of measurement data is displayed in the measurement data display area, displays measurement data to be moved at a movement destination position in response to a user's selection of one piece of movement data to be moved among the one or more pieces of measurement data and one movement destination position in the blank space, and displays, as the blank space, the position at which the measurement data to be moved has been present after changing the display position of the measurement data to be moved.

Description

Technical Field

[0001] The present disclosure relates to a biological particle sorting device, a biological particle sorting system, and an information processing device. More specifically, the present disclosure relates to a biological particle sorting device, a biological particle sorting system, and an information processing device that display a screen related to the control and / or execution of biological particle sorting processing.

Background Art

[0002] In flow cytometry, light derived from various fluorescent dyes is analyzed multidimensionally. For this analysis, a large number of graphs and / or tables of statistical values are displayed on the screen of an information processing device, and for example, gates are set or adjusted. Also, desired biological particles are sorted using the results of the analysis. The device that performs this sorting is also called a cell sorter. In recent years, a device for sorting biological particles in a closed space has also been proposed, and this device is also called a closed sorter.

[0003] Regarding closed sorters, several proposals have been made so far. For example, Patent Document 1 below includes a determination unit that determines whether to sort microparticles based on light generated by irradiating the microparticles flowing in a flow path, and the determination unit performs a primary sorting determination to determine whether the microparticles belong to any of two or more different microparticle populations based on the characteristics of the light, and then performs a secondary sorting determination to determine whether to sort the microparticles determined to belong to any of the microparticle populations in the primary sorting determination based on the specified particle composition ratios for the two or more different microparticle populations. A microparticle sorting device is disclosed.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

[0005] For the sorting process using a biological particle sorting device, sorting conditions such as gate settings are configured. These settings are made via various data displayed on the screen, as described above. Performing these settings often requires highly specialized knowledge (for example, knowledge of biological particles and sorting devices). The user interfaces of commercially available devices such as flow cytometers and cell sorters are designed on the assumption that the user possesses such specialized knowledge.

[0006] However, research and development and manufacturing of cell therapy drugs, for example, are carried out in cleanrooms to avoid contamination. Therefore, when using a biological particle sorting device such as a closed sorter in a cleanroom, it is assumed that user U will operate the biological particle sorting device A while wearing cleanroom work clothes and gloves, as shown in Figure 1. These gloves are laboratory gloves made of materials such as latex. When wearing such gloves, fine movements are often difficult. For example, fine movements of a touch panel are difficult when wearing these gloves. Therefore, it is desirable to provide a user interface that is easy to use or operate even under such conditions.

[0007] Therefore, the primary purpose of this disclosure is to improve the operability of a biological particle sorting device, and in particular, to improve the operability of the user interface of said device. [Means for solving the problem]

[0008] This disclosure is, It has a display unit that displays the measurement data display area, In a display mode in which one or more measurement data points are displayed in addition to a blank space within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After the display position of the moving target measurement data is changed, the position where the moving target measurement data was located will be displayed as a blank space. We provide a biological particle sorting device. The biological particle sorting device may be configured to display the one or more measurement data in a grid pattern within the measurement data display area. The biological particle sorting device may be configured to display candidate position images in the blank space, indicating positions where measurement data can be placed. The biological particle sorting device may be configured so as not to change the arrangement of measurement data other than the moving target measurement data before and after the moving of the moving target measurement data to the blank space. The biological particle sorting device has multiple display modes. The biological particle sorting device may, depending on which display mode is selected from the plurality of display modes to display the blank space, make the blank space appear in the measurement data display area, or The biological particle sorting device may make the blank space appear in the measurement data display area when a display mode for displaying the blank space is selected from among the plurality of display modes and when the measurement data to be moved is selected. The number of columns in the measurement data display area where measurement data can be placed may be predetermined. The biological particle sorting device may be configured to display a setting panel for changing the number of rows. The biological particle sorting device may increase the number of columns depending on the display mode selected to display the blank space. The biological particle sorting device may display the increased number of columns as blank spaces. The aforementioned settings panel may be displayed semi-transparently. The biological particle sorting device may be configured to display a gate editing panel for editing the gate set in the measurement data, and the gate editing panel may be configured to allow the user to select the gate to be edited. The gate editing panel may be configured to allow the user to select the entire selected gate or its components as the target for editing. The biological particle sorting device is configured to display a plot or axis editing panel for editing the display format and / or axes of the measurement data. The plot or axis editing panel may be configured to allow the user to select the axis to be edited. In addition to the measurement data display area, the display unit also displays a sorting operation control area that displays buttons for controlling the sorting operation by the biological particle sorting device. The biological particle sorting device may be configured to display data associated with the sorting operation control area on the measurement data display area. In addition to the measurement data display area, the display unit also displays an operation button area for displaying one or more operation buttons used to set the sorting conditions. The biological particle sorting device may be configured such that, depending on the selection of any of the one or more operation buttons, the operation button area can be expanded and displayed on the measurement data display area. A button for selecting a display mode to show the blank space may be displayed in the aforementioned operation button area. The display unit may be configured to allow touch input. Furthermore, this disclosure is, It has a display unit that displays the measurement data display area, In a display mode in which one or more measurement data points are displayed in addition to a blank space within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After changing the display position of the measurement data to be moved, the position where the measurement data to be moved existed is displayed as a blank space. A biological particle sorting system is also provided. In addition, the present disclosure has a display unit that displays a measurement data display area, in a display mode in which a blank space is displayed in addition to one or more pieces of measurement data within the measurement data display area, in response to a user selecting one piece of measurement data to be moved among the one or more pieces of measurement data and one destination position within the blank space, the measurement data to be moved is displayed at the destination position, After changing the display position of the measurement data to be moved, the position where the measurement data to be moved existed is displayed as a blank space. An information processing apparatus is also provided.

Brief Description of the Drawings

[0009] [Figure 1] It is a schematic diagram showing an example of a situation in which a biological particle sorting device is being operated. [Figure 2A] It is a diagram showing a configuration example of the biological sample analysis device of the present disclosure. [Figure 2B] It is an example of a block diagram of the biological particle sorting device of the present disclosure. [Figure 3] It is an example of a screen displayed by the biological particle sorting device of the present disclosure. [Figure 4] It is an example of a screen displayed by the biological particle sorting device of the present disclosure, and is a diagram for explaining three areas that may be included in the screen. [Figure 5] It is a diagram for explaining a first display area. [Figure 6A] It is a diagram for explaining a second display area. [Figure 6B] It is a diagram for explaining a scroll bar displayed in the second display area. [Figure 7] It is a diagram for explaining a third display area. [Figure 8]This diagram illustrates an example of how measurement data is arranged in the second display area. [Figure 9A] This is a diagram illustrating the operation of moving measurement data to a blank space. [Figure 9B] This is a diagram illustrating the operation of moving measurement data to a blank space. [Figure 9C] This is a diagram illustrating the operation of moving measurement data to a blank space. [Figure 10] This is a diagram to explain how measurement data is transferred. [Figure 11A] This is a diagram illustrating the operation of moving measurement data to a blank space. [Figure 11B] This is a diagram illustrating the operation of moving measurement data to a blank space. [Figure 11C] This is a diagram illustrating the operation of moving measurement data to a blank space. [Figure 12A] This diagram illustrates the operation of moving measurement data to a location where other measurement data already exists. [Figure 12B] This diagram illustrates the operation of moving measurement data to a location where other measurement data already exists. [Figure 12C] This diagram illustrates the operation of moving measurement data to a location where other measurement data already exists. [Figure 12D] This diagram illustrates the operation of moving measurement data to a location where other measurement data already exists. [Figure 13A] This diagram illustrates the operation of deleting rows or columns that contain only blank spaces. [Figure 13B] This diagram illustrates the operation of deleting rows or columns that contain only blank spaces. [Figure 13C] This diagram illustrates the operation of deleting rows or columns that contain only blank spaces. [Figure 13D] This diagram illustrates the operation of deleting rows or columns that contain only blank spaces. [Figure 14A]This diagram illustrates the screen transitions where a blank space is displayed depending on the Plot Arrange View mode selected. [Figure 14B] This diagram illustrates the screen transitions where a blank space is displayed depending on the Plot Arrange View mode selected. [Figure 14C] This diagram illustrates the screen transitions where a blank space is displayed depending on the Plot Arrange View mode selected. [Figure 14D] This diagram illustrates the screen transitions where a blank space is displayed depending on the Plot Arrange View mode selected. [Figure 15A] This is a diagram illustrating an example of how to display the gate editing panel. [Figure 15B] This is a diagram illustrating an example of how to display the gate editing panel. [Figure 15C] This is a diagram illustrating an example of how to display the gate editing panel. [Figure 16] This is a diagram illustrating an example configuration of the gate editing panel. [Figure 17] This is a diagram illustrating the dropdown menu in the gate editing panel. [Figure 18A] This is a diagram illustrating examples of how the plot / axis editing panel is displayed. [Figure 18B] This is a diagram illustrating examples of how the plot / axis editing panel is displayed. [Figure 18C] This is a diagram illustrating examples of how the plot / axis editing panel is displayed. [Figure 19] This is a diagram illustrating an example of the plot / axis editing panel configuration. [Figure 20A] This is a diagram illustrating an example of how the worksheet settings panel can be displayed. [Figure 20B] This is a diagram illustrating an example of how the worksheet settings panel can be displayed. [Figure 20C] This is a diagram illustrating an example of how the worksheet settings panel can be displayed. [Figure 20D] This is a diagram illustrating an example of how the worksheet settings panel can be displayed. [Figure 21] This diagram illustrates an example of the configuration of the worksheet settings panel. [Figure 22A] This figure shows an example of an embodiment in which the content displayed in the first display area is superimposed on the second display area. [Figure 22B] This figure shows an example of an embodiment in which the content displayed in the first display area is superimposed on the second display area. [Figure 22C] This figure shows an example of an embodiment in which the content displayed in the first display area is superimposed on the second display area. [Figure 23A] This figure shows an example of an embodiment in which the content displayed in the third display area is superimposed on the second display area. [Figure 23B] This figure shows an example of an embodiment in which the content displayed in the third display area is superimposed on the second display area. [Figure 23C] This figure shows an example of an embodiment in which the content displayed in the third display area is superimposed on the second display area. [Figure 24] This figure shows an example of a biological particle sorting system in accordance with this disclosure. [Figure 25] This is a diagram illustrating an example of the plot / axis editing panel configuration. [Modes for carrying out the invention]

[0010] The following describes preferred forms for implementing this disclosure. The embodiments described below are representative of the disclosure, and the scope of this disclosure is not limited to these embodiments. The description of this disclosure will proceed in the following order. 1. Basic Concepts of This Disclosure 2. First Embodiment of the Present Disclosure (Biological Particle Separation Apparatus) (1) Example of device configuration (2) Example of the displayed screen (2-1) Screen for setting processing conditions (2-2) Data transfer processing (using blank spaces) (2-2-1) Processing of moving measurement data to blank space (2-2-2) Processing to move measurement data to a location where other measurement data exists. (2-2-3) Deletion of blank rows or columns (2-2-4) Display method for blank spaces (2-3) Control Panel (2-3-1) Gate Editing Panel (2-3-2) Plot / Axis Editing Panel (2-3-3) Measurement data display area setting panel (2-4) Display process that overlays the contents of other display areas onto the measurement data display area. (2-4-1) Embodiment in which the content displayed in the first display area is superimposed on the second display area. (2-4-2) Embodiment in which the content displayed in the third display area is superimposed on the second display area. (3) Variant 3. A second embodiment of the present disclosure (bioparticle sorting system)

[0011] 1. Basic Concepts of This Disclosure

[0012] As mentioned above, when operating a biological particle sorting device in a cleanroom, it is common for the user to wear gloves. When wearing such gloves, fine motor skills are often difficult. For example, fine motor skills are difficult when using a touch panel while wearing gloves. Therefore, it is desirable to provide a user interface that is easy to use or operate even under these conditions.

[0013] Furthermore, the sorting setting screens of many bioparticle sorting devices are designed with the assumption that users with specialized knowledge will perform detailed settings, requiring precise operation. These setting screens typically involve moving a cursor on the window using a mouse, for example. Such screens are not designed for touch operation, and setting them via touch is often difficult.

[0014] Furthermore, the sorting conditions screen of a bioparticle sorting device (e.g., the gate setting screen) displays multiple measurement data (e.g., plot data and / or histogram data). While it is desirable to be able to freely change the arrangement of these multiple measurement data, if the arrangement of these multiple measurement data changes significantly before and after the arrangement change, it may be difficult for the user who has set the sorting conditions to use. For example, if gate settings have already been completed for some of the plot data, it may be undesirable for the user if the arrangement of such gate-set plot data is changed.

[0015] A biological particle sorting device according to this disclosure includes a display unit that displays a measurement data display area. In a display mode in which the biological particle sorting device displays one or more measurement data in addition to a blank space within the measurement data display area, the biological particle sorting device displays the measurement data to be moved at the destination position in response to a user selecting one of the one or more measurement data and one destination position in the blank space, and displays the position where the measurement data to be moved was located as a blank space after the display position of the measurement data to be moved has been changed. By changing the display position of the measurement data in this way, it becomes easier to move the measurement data, for example, by touch operation. Furthermore, the need to change the arrangement of other measurement data before and after the display position change is reduced. This prevents confusion for the user due to changes in the arrangement of measurement data. In addition, since the location where the moved measurement data was located is displayed as a blank space, it is easy to understand which measurement data has had its arrangement changed before and after the move and which has maintained its arrangement.

[0016] The display unit may be included as a component of an information processing device that controls a biological particle sorting device. That is, the present disclosure also provides an information processing device including the display unit. Furthermore, the display unit may be included as a component of the biological particle sorting system. For example, the display unit may be included as a component of a biological particle sorting system in which one or more biological particle sorting devices and one or more information processing devices are connected via a network. In such a system, the display unit may be provided in the information processing device or in the biological particle sorting device.

[0017] The following describes, first, an example of the device configuration, and then, an example of a screen displayed in accordance with this disclosure.

[0018] 2. First Embodiment of the Present Disclosure (Biological Particle Separation Apparatus)

[0019] (1) Example of device configuration

[0020] A biological particle sorting device according to this disclosure may be configured as a biological sample analysis device as described below.

[0021] An example of the configuration of the biological sample analyzer of this disclosure is shown in Figure 2A. The biological sample analyzer 6100 shown in Figure 2A includes a light irradiation unit 6101 that irradiates light onto a biological sample S flowing through a channel C, a detection unit 6102 that detects the light generated by irradiating the biological sample S, and an information processing unit 6103 that processes information related to the light detected by the detection unit. Examples of the biological sample analyzer 6100 include a flow cytometer and an imaging cytometer. The biological sample analyzer 6100 may also include a sorting unit 6104 that sorts specific biological particles P within the biological sample. An example of the biological sample analyzer 6100 including the sorting unit is a cell sorter.

[0022] (Biological sample) The biological sample S may be a liquid sample containing biological particles. These biological particles may be, for example, cells or non-cellular biological particles. The cells may be living cells, and more specifically, blood cells such as red blood cells and white blood cells, and germ cells such as sperm and fertilized eggs. The cells may be directly collected from a sample such as whole blood, or they may be cultured cells obtained after culturing. Examples of non-cellular biological particles include extracellular vesicles, particularly exosomes and microvesicles. The biological particles may be labeled with one or more labeling substances (for example, dyes (particularly fluorescent dyes) and fluorescent dye-labeled antibodies). The biological sample analyzer of this disclosure may also analyze particles other than biological particles, and beads may be analyzed for calibration purposes.

[0023] (Flow channel) The channel C is configured to allow a biological sample S to flow through it. In particular, the channel C may be configured to form a flow in which biological particles contained in the biological sample are arranged in a substantially straight line. The channel structure including the channel C may be designed to form a laminar flow. In particular, the channel structure is designed to form a laminar flow in which the flow of the biological sample (sample flow) is surrounded by the flow of the sheath fluid. The design of the channel structure may be appropriately selected by those skilled in the art, and known designs may be adopted. The channel C may be formed in a flow channel structure such as a microchip (a chip with a channel on the order of micrometers) or a flow cell. The width of the channel C is 1 mm or less, and in particular may be 10 μm or more and 1 mm or less. The channel C and the channel structure including it may be formed from materials such as plastic or glass.

[0024] The biological sample analyzer of this disclosure is configured such that light from the light irradiation unit 6101 is irradiated onto a biological sample, particularly biological particles, flowing through the channel C. The biological sample analyzer of this disclosure may be configured such that the light irradiation point (interrogation point) for the biological sample is located within the channel structure in which the channel C is formed, or it may be configured such that the light irradiation point is located outside the channel structure. An example of the former is a configuration in which the light is irradiated onto the channel C in a microchip or flow cell. In the latter case, the light may be irradiated onto biological particles after they have exited the channel structure (particularly its nozzle), for example, a Jet-in-Air type flow cytometer.

[0025] (Light irradiation area) The light irradiation unit 6101 includes a light source unit that emits light and a light guide optical system that guides the light to the irradiation point. The light source unit includes one or more light sources. The type of light source is, for example, a laser light source or an LED. The wavelength of the light emitted from each light source may be any of the wavelengths of ultraviolet light, visible light, or infrared light. The light guide optical system includes optical components such as a beam splitter group, a mirror group, or an optical fiber. The light guide optical system may also include a lens group for focusing the light, for example, an objective lens. There may be one or more irradiation points where the light intersects with the biological sample. The light irradiation unit 6101 may be configured to focus light irradiated from one or more different light sources to a single irradiation point.

[0026] (Detection unit) The detection unit 6102 includes at least one photodetector that detects light generated by light irradiation of biological particles. The light to be detected is, for example, fluorescence or scattered light (e.g., one or more of forward scattered light, back scattered light, and side scattered light). Each photodetector includes one or more photoreceiving elements, for example, a photoreceiving element array. Each photodetector may include one or more PMTs (photomultiplier tubes) and / or photodiodes such as APDs and MPPCs as photoreceiving elements. The photodetector may include, for example, a PMT array in which multiple PMTs are arranged in a one-dimensional direction. The detection unit 6102 may also include an image sensor such as a CCD or CMOS. The detection unit 6102 can acquire images of biological particles (e.g., bright-field images, dark-field images, and fluorescence images) using the image sensor.

[0027] The detection unit 6102 includes a detection optical system that directs light of a predetermined detection wavelength to a corresponding photodetector. The detection optical system includes a spectroscopic unit such as a prism or diffraction grating, or a wavelength separation unit such as a dichroic mirror or optical filter. The detection optical system is configured to spectrally analyze light generated by, for example, irradiation of biological particles, and to detect the spectrally analyzed light using a plurality of photodetectors, more than the number of fluorescent dyes on which the biological particles are labeled. A flow cytometer including such a detection optical system is called a spectral flow cytometer. The detection optical system is also configured to separate light corresponding to the fluorescence wavelength range of a specific fluorescent dye from light generated by, for example, irradiation of biological particles, and to detect the separated light using a corresponding photodetector.

[0028] Furthermore, the detection unit 6102 may include a signal processing unit that converts the electrical signal obtained by the photodetector into a digital signal. The signal processing unit may include an A / D converter as the device that performs the conversion. The digital signal obtained by the conversion by the signal processing unit may be transmitted to the information processing unit 6103. The digital signal may be treated by the information processing unit 6103 as data related to light (hereinafter also referred to as "light data"). The light data may be, for example, light data including fluorescence data. More specifically, the light data may be light intensity data, and the light intensity may be light intensity data of light including fluorescence (which may include feature quantities such as Area, Height, and Width).

[0029] (Information Processing Department) The information processing unit 6103 includes, for example, a processing unit that performs processing of various data (e.g., optical data) and a storage unit that stores various data. When the processing unit obtains optical data corresponding to a fluorescent dye from the detection unit 6102, it may perform fluorescence leakage correction (compensation processing) on ​​the optical intensity data. In the case of a spectral flow cytometer, the processing unit also performs fluorescence separation processing on the optical data to obtain optical intensity data corresponding to the fluorescent dye. The fluorescence separation processing may be performed, for example, according to the unmixing method described in Japanese Patent Application Publication No. 2011-232259. If the detection unit 6102 includes an image sensor, the processing unit may obtain morphological information of biological particles based on the image obtained by the image sensor. The storage unit may be configured to store the acquired optical data. The storage unit may further be configured to store spectral reference data used in the unmixing processing.

[0030] If the biological sample analyzer 6100 includes a sorting unit 6104 as described below, the information processing unit 6103 may determine whether to sort biological particles based on optical data and / or morphological information. Based on the result of this determination, the information processing unit 6103 controls the sorting unit 6104, and the sorting of biological particles by the sorting unit 6104 may be performed.

[0031] The information processing unit 6103 may be configured to output various types of data (e.g., optical data and images). For example, the information processing unit 6103 may output various types of data (e.g., two-dimensional plots, spectral plots, etc.) generated based on the optical data. The information processing unit 6103 may also be configured to accept input of various types of data, for example, to accept gating processing on a plot by a user. The information processing unit 6103 may include an output unit (e.g., a display) or an input unit (e.g., a keyboard) for executing such output or input.

[0032] The information processing unit 6103 may be configured as a general-purpose computer, for example, as an information processing device equipped with a CPU, RAM, and ROM. The information processing unit 6103 may be contained within the housing that houses the light irradiation unit 6101 and the detection unit 6102, or it may be located outside of that housing. Furthermore, various processing or functions performed by the information processing unit 6103 may be implemented by a server computer or cloud connected via a network.

[0033] (Preparative separation section) The sorting unit 6104 performs sorting of biological particles according to the determination result by the information processing unit 6103. The sorting method may be one in which droplets containing biological particles are generated by vibration, an electric charge is applied to the droplets to be sorted, and the direction of movement of the droplets is controlled by electrodes. The sorting method may also be one in which the direction of movement of biological particles is controlled and sorted within a flow channel structure. The flow channel structure may be provided with a control mechanism, for example, by pressure (injection or suction) or electric charge. An example of such a flow channel structure is a chip (for example, the chip described in Japanese Patent Application Publication No. 2020-76736) in which a flow channel C has a flow channel structure in which a recovery flow channel and a waste liquid flow channel branch downstream thereof, and specific biological particles are recovered into the recovery flow channel.

[0034] (2) Example of the displayed screen

[0035] A biological particle sorting apparatus according to this disclosure may have a touch-enabled display unit D, as shown in Figure 1, for example. The display unit may be located on any side, particularly the side, of the housing of the apparatus, as shown in the same figure, and the screen of the display unit may be located in a position where a user standing (or sitting) near the apparatus can touch it. The display unit may display a screen for setting processing conditions, as described later. Also, as shown in the same figure, a biological particle sorting apparatus according to this disclosure may have an introduction unit I for introducing a biological particle-containing sample into the apparatus. For example, a container containing the sample is placed inside the apparatus through the introduction unit, and the container is connected to a predetermined sample line. After this connection, sorting processing may be performed.

[0036] Figure 2B shows an example of a block diagram of a biological particle sorting device according to the present disclosure. As shown in the figure, the biological particle sorting device 100 according to the present disclosure has a display unit 101. The biological particle sorting device 100 may further have an information processing unit 102.

[0037] The display unit 101 outputs a screen in accordance with this disclosure. In particular, the display unit 101 displays a processing condition setting screen that accepts input of sorting condition data related to the sorting process of a sample containing biological particles. Note that a processing condition setting screen for performing only analysis without sorting may also be displayed. The screen displayed by the display unit 101 may be a screen based on data transmitted from the information processing unit 102.

[0038] The display unit 101 may include display devices known in the art. For example, the display unit 101 includes a display device having a rectangular screen, more particularly a rectangular screen, and more particularly a wide rectangular screen. The size of the screen may be, for example, 10 inches or more, preferably 11 inches or more, and more preferably 12 inches or more. There is no particular upper limit set for the size of the screen, but it may be, for example, 30 inches or less, 25 inches or less, 22 inches or less, or 20 inches or less. Such screen sizes are suitable for displaying the screens shown in each mode described below.

[0039] The information processing unit 102 causes the display unit 101 to display a screen in accordance with this disclosure. The information processing unit 102 is configured to transmit data for displaying the screen to the display unit 101. The information processing unit 102 may be the information processing unit 6103 described in (1) above, but it may also be a separately prepared information processing unit. In addition to the display unit 101 and the information processing unit 102, the biological particle sorting device 100 may also include the light irradiation unit 6101, the detection unit 6102, and the sorting unit 6104 described in (1) above.

[0040] The biological particle sorting device 100 (particularly the information processing unit 102) accepts sorting condition data related to the biological particle sorting process. To accept this sorting condition data, the display unit 101 may be touch-enabled.

[0041] The information processing unit 102 displays the processing condition setting screen on the display unit 101. The information processing unit 102 receives the input of the sorting condition data via the processing condition setting screen. The processing condition setting screen may be displayed on a display device other than the display unit 101 provided in the biological particle sorting device 100. For example, the biological particle sorting device 100 may display the screen on a display device or information processing device connected to the biological particle sorting device 100 via a wired or wireless network.

[0042] The following describes the screens displayed by the biological particle sorting device 100 in accordance with this disclosure. First, an example of the screen configuration will be described, followed by a description of the display control in accordance with this disclosure.

[0043] (2-1) Screen for setting processing conditions

[0044] The biological particle sorting device 100 displays a screen on its display unit, for example, as shown in Figure 3. The screen 300 shown in the same figure is a screen for setting sorting conditions for the biological particle sorting process. As shown by the dashed lines in Figure 4, the screen includes a sorting operation control area (hereinafter also referred to as the "first display area") 301 that displays buttons for controlling (especially executing) sorting operations by the biological particle sorting device 100, a measurement data display area (hereinafter also referred to as the "second display area") 302 that displays one or more measurement data used to set sorting conditions, and an operation button area (hereinafter also referred to as the "third display area") 303 that displays one or more operation buttons used to set sorting conditions (e.g., gate information). The operation buttons may include call buttons for displaying various operation panels for setting sorting conditions.

[0045] As shown in these figures, the first display area, the second display area, and the third display area are located on the left, center, and right sides, respectively, of the processing condition setting screen. These three areas may be arranged in this order from left to right. Alternatively, the first display area, the second display area, and the third display area may be located on the right, center, and left sides, respectively, of the processing condition setting screen. These three areas may also be arranged in this order from right to left. Note that the arrangement of these three areas is not limited to what is described above; for example, they may be arranged from top to bottom, or from bottom to top. Often, to display a large amount of measurement data more prominently, the second display area may be configured to occupy the largest area of ​​the 300-unit screen. In some cases, detailed settings are required for the sorting conditions. For example, it may be necessary to verify detailed measurement data, or to display a large number of plotted data and / or histograms on a single screen. As described above, by providing three areas, the second display area can be made larger, making it easier for the user to check the measurement data.

[0046] To improve operability, when the first display area is located on the left side of the processing condition setting screen and the third display area is located on the right side of the processing condition setting screen, the first display area may be positioned to touch the left edge of the processing condition setting screen, and the third display area may be positioned to touch the right edge of the processing condition setting screen. Conversely, when the first display area is located on the right side of the processing condition setting screen and the third display area is located on the left side of the processing condition setting screen, the first display area may be positioned to touch the right edge of the processing condition setting screen, and the third display area may be positioned to touch the left edge of the processing condition setting screen. Because the first and third display areas are adjacent to the edges of the screen, unintended touches can be prevented during touch input.

[0047] The arrangement of the three areas described above may be changed. For example, the biological particle sorting device may be configured to change the screen from a state where the first display area is on the right and the third display area is on the left to a state where the former area is on the left and the latter area is on the right. It may also be configured to change the screen in the opposite direction. This can accommodate the user's dominant hand or convenience and improve operability.

[0048] (First display area) The first display area 300 will be described below with reference to Figure 5. As shown in the figure, the first display area includes area 311, which contains one or more buttons for controlling the flow of the biological particle-containing sample into the device (particularly into the microchip where sorting is performed); area 312, which contains one or more buttons for controlling the recording of detection results by the detection unit; and area 313, which contains one or more buttons for controlling the sorting operation. The items to be displayed in these areas and the buttons to be placed in these areas may be appropriately selected by those skilled in the art.

[0049] For example, area 311 may include a start button to begin flowing the biological particle-containing sample into the device and a stop button to stop flowing the biological particle-containing sample into the device. Area 311 may also display the elapsed time since the start of flowing the biological particle-containing sample into the device, the total number of events detected, and the event rate. Area 312 may include a button (Record button) for controlling the recording of data on particles detected by the detection unit. Area 312 may also display the elapsed time since the start of recording and the number of recorded events. Area 313 may include a start button to initiate the sorting process of biological particles and a stop button to stop the sorting. Area 313 may also display a button for performing calibration for sorting. Although not shown in the figure, area 313 may also display data indicating the sorting status (e.g., elapsed time).

[0050] Furthermore, as shown in the figure, the first display area may display, for example, the name of the experimental file and the name of the worksheet for specifying the sorting conditions. The worksheet contains data such as measurement data and sorting condition data (e.g., gate information). The biological particle sorting device 100 is configured so that the user can set gates for the measurement data on the worksheet. The biological particle sorting device 100 is also configured so that particles can be sorted based on the gates set on the worksheet. Furthermore, as shown in the figure, the first display area may also display buttons for displaying user properties, buttons for displaying error information, buttons for starting or ending the sorting process, etc., but these may also be displayed in other areas.

[0051] (Second display area) The second display area will be described below with reference to Figure 6A. As shown in the figure, one or more measurement data points are displayed in the second display area. These one or more measurement data points are generated by the information processing unit based on the detection results from the detection unit. Each measurement data point may be, for example, histogram data or plot data (e.g., density plot data, dot plot data, or contour plot data). The specific configuration of these measurement data points may be selected as appropriate by the user. In the figure, the second display area is divided into area 321, which displays the experimental file name and worksheet name, and area 322, which displays the measurement data. However, the configuration of the second display area is not limited to what is shown in the figure. In the figure, a worksheet named "Worksheet 1" is selected, and the six measurement data contained in that worksheet are displayed. In the first row, three measurement data are plotted data, and each plotted data has a gate set. The second row also displays three measurement data, two of which are histogram data and one is plotted data. As shown in area 321 of the figure, an experimental file named "Experiment 04 / 04 / 2021 23:09:01" is open, and it is indicated that this experimental file contains multiple worksheets (Worksheet 1, Worksheet 2, and Worksheet 3). These multiple worksheets may be switched between active and inactive states by selecting a tab. In the figure, the Worksheet 1 tab is selected, and Worksheet 1 is active.

[0052] Preferably, the biological particle sorting device 100 displays the one or more measurement data in a grid. That is, the one or more measurement data may be displayed so as to form one or more rows and one or more columns. For example, in the figure, area 322 can arrange measurement data in a grid of 3 rows and 4 columns. The number of columns for measurement data in this area is 4, meaning that 4 measurement data can be placed per row. The number of columns for measurement data in this area may be predetermined. Furthermore, the setting of the number of columns for measurement data in this area may be changed by the user. This allows the measurement data set to be displayed in an arrangement that is easy for each user to use. Furthermore, the number of rows for measurement data in this area is 3, and 3 measurement data can be placed in one column. For example, in the first column from the left, 2 measurement data and 1 blank space are placed. In the diagram, it is shown that 3 measurement data can be placed per column, but the number of rows may be increased or decreased depending on the number of measurement data. In this disclosure, the biological particle sorting device 100 may have a set number of columns of measurement data displayed in the measurement data display area. The biological particle sorting device 100 may be configured to increase or decrease the number of rows of measurement data according to the number of measurement data, while maintaining the set number of columns. Furthermore, if the number of rows increases and some rows cannot be displayed on the screen, the biological particle sorting device 100 may be configured to display a scroll bar 323, for example, as shown in Figure 6B. By operating this scroll bar, the increase in the number of rows can be accommodated. An increase in the number of columns may also be handled by displaying a scroll bar.

[0053] In Figure 6A, blank spaces are displayed in the rightmost column and the bottommost row. These blank spaces may be displayed when a specific display mode is selected, but may not be displayed when other display modes are selected.

[0054] (Third display area) The third display area will be explained below with reference to Figure 7. As shown in the figure, the third display area displays multiple buttons. These operation buttons include one or more buttons used to set sorting conditions (which include, for example, gate information; also called analysis conditions if sorting is not performed). More specifically, these operation buttons may include operation buttons for setting gates for measurement data in the second display area or operation buttons for editing the measurement data itself. These operation buttons may include one or more call buttons for displaying various operation panels for setting sorting conditions.

[0055] Examples of operation buttons include, for example, the Redo button, Undo button, zoom in button, and zoom out button, as shown in the figure. Examples of call buttons may also include the Plot button, Gate button, View button, and Settings button, as shown in the figure. When these buttons are tapped, the plot operation panel, gate operation panel, display mode operation panel, and settings operation panel may be displayed on the processing condition setting operation screen, respectively. Furthermore, the third display area may display buttons for changing the display mode in the second display area. For example, the biological particle sorting device 100 changes the second display area to Plot arrange view mode in response to the user selecting (especially tapping) the Plot arrange view button in the third display area. In Plot arrange view mode, the biological particle sorting device 100 accepts changes to the arrangement of measurement data (e.g., plot data and / or histogram data) displayed in the second display area. This mode is also called data arrangement adjustment mode. Thus, buttons for selecting a display mode that displays blank space may be displayed in the third display area (operation button area). In a preferred embodiment, the biological particle sorting device 100 makes a blank space appear in the measurement data display area where measurement data can be placed when the Plot arrange view button is tapped. Before the Plot arrange view button is tapped, the blank space does not need to be displayed in the measurement data display area. Then, in response to the tap, the blank space is added to constitute the rightmost column and / or bottommost row of the measurement data display area, for example, as shown in Figure 3.

[0056] The call button may also display other operation buttons within the third display area. For example, when the View button is selected, the Plot Arrange View mode selection button and other View mode selection buttons described later may be displayed within the third display area. For example, in the initial state, the biological particle sorting device 100 may display only the buttons in the right column of the button group shown in Figure 7. Then, when the View button is selected, the buttons in the left column of the button group shown in Figure 7 may be displayed within the third display area. In this specification, View mode is also referred to as display mode. The biological particle sorting device of this disclosure may have multiple display modes, and may be configured so that the user can select any of these display modes. Furthermore, depending on whether the Settings button is selected, the Worksheet Settings button and other Settings buttons described later may be displayed in the third display area.

[0057] (2-2) Data transfer processing (using blank spaces)

[0058] In Plot arrange view mode, the biological particle sorting device 100 displays measurement data (e.g., histogram data or plot data) in a second display area. This measurement data may be arranged in a grid, as shown in Figure 8. The arrangement of this measurement data can be changed by user operation. Plot arrange view mode is an example of a "display mode that displays blank space in addition to one or more measurement data points within the measurement data display area" in this disclosure.

[0059] (Composition of blank spaces) As shown in the figure, a blank space is displayed within the second display area where measurement data can be placed. The blank space may be provided at the far right of the second display area, as indicated by reference numerals 331-1 to 331-3 in the figure, to allow for the placement of a column of measurement data. Conversely, it may be provided at the far left of the second display area to allow for the placement of a column of measurement data. Additional blank space equivalent to two or more columns of measurement data may be added, but the blank space introduced as a column to display already displayed measurement data larger is preferably the space equivalent to one column of measurement data. Furthermore, blank space may be provided at the bottom of the second display area, as indicated by reference numerals 331-3 to 331-6 in the figure, to allow for the placement of one line of measurement data. Conversely, blank space may be provided at the top of the second display area to allow for the placement of one line of measurement data. Blank space equivalent to two or more lines of measurement data may be added, but the blank space introduced as a line to display already displayed measurement data larger is preferably the space equivalent to one line of measurement data.

[0060] The blank space may display candidate position images indicating possible locations for the measurement data. For example, as shown by reference numerals 331-1 to 331-6 in the figure, the spaces where the measurement data will be placed may be indicated by dashed polygons (especially quadrilaterals). Alternatively, the candidate position images may be colored polygons or blinking polygons. In addition, any mark indicating a candidate position may be displayed. Thus, the biological particle sorting device 100 may be configured to display candidate position images indicating possible locations for the measurement data in the blank space. Such candidate position images make it easier to confirm where the measurement data will be moved to and to predict the state within the second display area after the move.

[0061] (2-2-1) Processing of moving measurement data to blank space

[0062] (Move measurement data to blank space by tapping) The operation of moving measurement data to a blank space will be explained with reference to Figures 9A-C. Six measurement data are displayed in the measurement data display area shown in the figures. Of these, the user taps the plot data in the upper left as the measurement data to be moved, as shown in Figure 9A. Next, the user taps the blank space 331-2 as the destination for the measurement data to be moved, as shown in Figure 9B. In response to these two taps, the biological particle sorting device 100 displays the measurement data to be moved in the tapped blank space, as shown in Figure 9C. After the display position of the measurement data to be moved has been changed, the biological particle sorting device 100 displays the position where the measurement data to be moved was located as blank space 331-7. Furthermore, the placement of other measurement data remains unchanged before and after such movement. In other words, the biological particle sorting device 100 does not change the placement configuration of measurement data other than the moving measurement data before and after the movement of the moving measurement data to the blank space. Such changes in the display position of measurement data can be easily performed, for example, by tapping. Also, since a blank space is used, the placement of other measurement data does not need to be changed before and after the change in display position, thereby preventing confusion for the user due to changes in the placement of measurement data. In addition, since the position where the moving measurement data was located is displayed as a blank space, it is easy to understand which measurement data has had its placement changed before and after the movement and which measurement data has maintained its placement before and after the movement.

[0063] (Method for moving measurement data into blank spaces) As described above, the biological particle sorting device 100 displays the data to be moved at the destination location when the user selects the data to be moved and selects the destination location. When the data to be moved is moved from the original location to the destination location, the status of the data being moved may be displayed, or it may not be displayed. In the former case, as shown in Figure 10, for example, the biological particle sorting device 100 displays, for example, the movement of the target measurement data from its original position to the destination position, in response to the user selecting the target measurement data and the destination position. This allows the user to visually confirm the movement status and easily verify the destination. In the latter case, the biological particle sorting device 100 may, in response to the user selecting the data to be moved and the destination location, erase the data that was present at the previous location and change that location to a blank space, and then make the data appear at the destination location. This reduces the time required to display the movement compared to the former case. For example, the image switch from Figure 9B to Figure 9C occurs simultaneously with the tap shown in Figure 9B.

[0064] (Moving measurement data to blank spaces using drag and drop operations) The above describes an embodiment in which measurement data is moved by tapping; however, in this disclosure, measurement data may also be moved by dragging and dropping. That is, the measurement data to be moved may be selected and moved by dragging, and the destination position may be selected by dropping. This movement method will be described below. The operation of moving measurement data to a blank space will be explained with reference to Figures 11A-C. Six measurement data points are displayed in the measurement data display area shown in the figures. As shown in Figure 11A, the user touches the plot data in the upper left corner as the measurement data to be moved. Next, as shown in Figure 11B, the user performs a drag operation to the destination position. That is, the user keeps touching the screen and moves their finger to the destination of the measurement data to be moved. As shown in Figure 11C, once the finger reaches the destination position, the user lifts their finger from the screen. As a result, the measurement data to be moved is placed at the destination position. The original position where the measurement data to be moved was located is displayed as a blank space. Changing the display position of such measurement data is also useful, as mentioned above regarding moving measurement data by tapping.

[0065] (2-2-2) Processing to move measurement data to a location where other measurement data exists.

[0066] (Moving measurement data to a location where other measurement data exists via tap operation) The operation of moving measurement data to a location where other measurement data exists will be explained with reference to Figures 12A-C. Six measurement data are displayed in the measurement data display area shown in the figure. Of these, the user taps the plot data (All Events) in the upper left corner as the measurement data to be moved, as shown in Figure 12A. Note that, in order to distinguish it from the tap operation described above (2-2-1), the tap operation to perform this movement operation may be a different touch operation, such as a long tap or a double tap. In response to the tap, the biological particle sorting device 100 displays insert buttons 341-1 to 341-5 in the measurement data display area, as shown in Figure 12B, indicating the insertion position of the tapped measurement data. These insert buttons may also display an indicator (a triangle in the figure) showing the direction of movement of other measurement data as measurement data is inserted. Next, as shown in Figure 12C, the user taps, for example, the insert button 341-1. In response to this tap, the bioparticle sorting device 100 moves the measurement data (Singlet 1) that was to the right of the insert button to the empty space to the right, as shown in Figure 12D, and displays the measurement data (All Events) in the position where the measurement data (Singlet 1) was located. If there is no blank space in the destination row for the move, any of the measurement data in that row may be moved to the next row, or the insert button may not be displayed to prevent the move. Thus, even in the process of moving such measurement data, after the display position of the measurement data to be moved has been changed, the biological particle sorting device 100 may display the position where the measurement data to be moved was located as a blank space. Changing the display position of such measurement data can be easily done, for example, by touch operation. Furthermore, since blank space is used, the need to change the arrangement of other measurement data before and after the display position change can be reduced, thereby preventing user confusion caused by changes in the arrangement of measurement data. In addition, since the location where the moved measurement data was located is displayed as blank space, it is easy to understand which measurement data has had its arrangement changed before and after the move and which has maintained its arrangement.

[0067] In the above-described movement process, as shown in Figure 12B, a cancel button 342 may be displayed for canceling the movement of the measurement data to be moved. For example, after tapping the measurement data to be moved as shown in Figure 12A, if the user taps the cancel button, the biological particle sorting device 100 cancels the movement process of the measurement data to be moved. In this cancellation process, the biological particle sorting device 100 removes the insertion button group and the cancel button described above from the screen.

[0068] (2-2-3) Deletion of blank rows or columns

[0069] (Deleting blank rows or columns by tapping) The biological particle sorting device 100 of this disclosure may be configured to delete rows or columns that contain only blank spaces. The operation of deleting rows or columns that contain only blank spaces will be explained with reference to Figures 13A to D. The measurement data display area shown in Figure 13A displays seven measurement data points, and also shows rows and columns that contain only blank spaces. The user taps one of the blank spaces in the row or column containing only blank spaces, as shown in the figure. In response to the tap, the biological particle sorting device 100 displays delete buttons 343-1 to 343-2 in the measurement data display area, as shown in Figure 13B, to delete rows or columns containing only blank spaces. These delete buttons may display an indicator (a triangle in the figure) showing the row or column to be deleted. Next, as shown in Figure 13C, the user taps, for example, the delete button 343-1. In response to this tap, the bioparticle sorting device 100 deletes all the blank spaces in the column where the delete button 343-1 is displayed, and moves the measurement data and blank spaces that were to the right of the column to be deleted one square to the left. Figure 13D shows the measurement data display area after the move. As shown in the same figure, the measurement data 344 has been moved to the position of the deleted blank space as a result of this deletion. By removing these blank spaces, unnecessary blank spaces are eliminated, allowing more measurement data to be displayed on the screen.

[0070] (2-2-4) Display method for blank spaces

[0071] The biological particle sorting apparatus of this disclosure may be configured to display a blank space in the measurement data display area when a predetermined mode is selected. If a mode other than the predetermined mode is selected, the blank space does not need to be displayed. The predetermined mode may be any mode in which the arrangement of measurement data may be changed or any mode in which the user wishes to change the arrangement of measurement data, and may be appropriately selected by a person skilled in the art. For example, the predetermined mode may be the Plot Arrange View mode described above. The screen transition in which a blank space is displayed in response to selecting the Plot Arrange View mode will be described below with reference to Figures 14A to D.

[0072] Figure 14A shows an example of the processing condition setting screen when Plot Arrange View mode is not selected. Six measurement data are displayed in the measurement data display area of ​​this screen, but no blank space is displayed where measurement data can be placed.

[0073] Suppose a user who wishes to change the arrangement of measurement data taps the Plot Arrange View button on the screen shown in Figure 14A, as shown in Figure 14B. In response to this tap, the bioparticle sorting device 100 gradually reduces the size of the six measurement data in the measurement data display area, as shown in Figure 14C. This reduction is performed in such a way that a blank space, as described later, is formed.

[0074] In parallel with or after the reduction process of the measurement data is completed, the biological particle sorting device 100 displays candidate position images indicating positions where the measurement data can be placed within the measurement data display area, as shown in Figure 14D. By making blank spaces appear within the measurement data display area in this way, it becomes easier for the user to recognize the presence of blank spaces. As described above, the biological particle sorting device 100 has multiple display modes, and the blank space may appear in the measurement data display area depending on which display mode is selected from among the multiple display modes to display the blank space.

[0075] Furthermore, without going through the process of reducing the measurement data as described above with reference to Figure 14C, the biological particle sorting device 100 may simultaneously switch the screen state from the screen state shown in Figure 14B to the screen state shown in Figure 14D. Furthermore, simply tapping the Plot Arrange View button does not necessarily require displaying a blank space. In this case, after tapping the Plot Arrange View button, the biological particle sorting device 100 may display a blank space as described above, depending on whether any of the moving target measurement data is selected (for example, by tapping or dragging). In response to the selection of a display mode that displays the blank space from among the multiple display modes and the selection of the measurement data to be moved, the blank space is made to appear in the measurement data display area. Thus, the biological particle sorting device 100 has multiple display modes, and in response to the selection of a display mode that displays the blank space from among the multiple display modes and the selection of the measurement data to be moved, the blank space may be made to appear in the measurement data display area.

[0076] (2-3) Control Panel

[0077] The biological particle sorting device 100 of this disclosure may be configured to display various operation panels for adjusting measurement data or sorting processing conditions (particularly gate settings) for the measurement data. These may be displayed on the processing condition setting screen in response to tapping a predetermined operation panel call button, and may particularly be displayed within the measurement data display area. Displaying the various operation panels in this manner, only when necessary, can reduce the adverse effect on the visibility of the measurement data. In one preferred embodiment, these operation panels may be semi-transparent. More specifically, the operation panels may be displayed within the measurement data display area and may be displayed semi-transparently so that the measurement data within the measurement data display area can be seen through them. This allows operations on the operation panel to be performed while confirming the measurement data. The following is an example of a control panel.

[0078] (2-3-1) Gate Editing Panel

[0079] The biological particle sorting device 100 may be configured to display a gate editing panel for editing the gate set for the measurement data. For example, as shown in Figure 15A, the user taps the Gate Edit Panel button on the processing condition setting screen 300. In response to this tap, the biological particle sorting device 100 displays the Gate Edit Panel 351 on the screen, specifically in the measurement data display area, as shown in Figure 15B. As shown in Figure 15B, the Gate Edit Panel may be opaque, that is, it may be displayed in a way that hides the measurement data behind it. Alternatively, the Gate Edit Panel may be semi-transparent or transparent, that is, it may be displayed in a way that allows the measurement data behind it to be seen through the Gate Edit Panel. For example, as shown in Figure 15C, a semi-transparent Gate Edit Panel 352 may be displayed in the measurement data area. The semi-transparent nature of the panel allows for gate editing while viewing the measurement data behind it.

[0080] The gate editing panel is an operation panel for editing the gates set in the measurement data. The gate editing panel will be explained below with reference to Figure 16.

[0081] The gate editing panel shown in Figure 16 includes a gate selection area 353 for selecting the gate to be edited. This gate selection area includes, for example, a drop-down menu 354 for selecting the gate to be edited. Depending on the selection made in the drop-down menu, the bioparticle sorting device 100 displays a list of editable gates. The user can select the gate they wish to edit from this list. The area may also display other operation buttons for selecting the gate to be edited, as well as the name of the selected gate. In the figure, "Singlet 1" is displayed below the drop-down menu as the selected gate name. Thus, the gate editing panel may be configured to allow the user to select the gate to be edited.

[0082] The gate editing panel further includes an operation target selection area 355 for selecting the component to be operated on from among the components of the gate selected in the gate selection area. The operation target selection area includes a dropdown menu 356 for selecting the operation target. The dropdown menu lists the editable items of the gate selected in the dropdown menu 354 in the gate selection area 353. In other words, the biological particle sorting device 100 changes the selectable components in the target selection area according to the gate selected in the gate selection area. The biological particle sorting device 100 acquires the editable item data for the gate when a gate is selected in the gate selection area. Then, based on the editable item data, the biological particle sorting device 100 generates a dropdown menu to be displayed in the target selection area.

[0083] The items to be listed for editing may include, for example, the entire gate and the four vertices that make up the gate, if the gate is a quadrilateral. The editable items listed may include, for example, the entire gate, the four vertices of the quadrilateral surrounding the entire gate, and the set of vertices of the polygon if the gate is a polygon other than a quadrilateral. The items to be listed for editing may include, for example, the entire gate, the four vertices of a rectangle that encloses the entire gate, and the center of the circle or ellipse, if the gate is circular or elliptical. Thus, the gate editing panel may be configured to allow the user to select the entire selected gate or its components as the target for editing.

[0084] An example of a dropdown menu is explained below with reference to Figure 17. The figure shows an example of a gate selected in the operation target selection area of ​​the gate editing panel (left side of the figure) and an example of a dropdown menu listing the editable items of that gate (right side of the figure). Gate 385, shown on the left side of the figure, is a polygonal gate. The editable items of this gate include the entire gate (Gate body), the four vertices of the rectangle that surround the entire gate (Corner Up left, Corner Up Right, Corner Down Left, and Corner Down Right), and the vertices of the polygon (Polygon vertex 1-7). These editable items are listed in the dropdown menu 386 shown on the right side of the figure. In this dropdown menu, Polygon vertex 1, one of the vertices of the polygon, is selected. In the left side of the figure, a mark 387 is placed next to the editable item selected in the dropdown menu, allowing the user to confirm the selected editable item.

[0085] In a preferred embodiment, a move handle button 388 for moving the gate or its components and / or a rotate handle button 389 for rotating the gate are displayed around the gate selected as the target of operation. Multiple buttons may be displayed surrounding the selected gate, as shown in the figure, for example, a total of four buttons may be displayed in the top, bottom, left, and right directions. When the user taps the move handle button, the bioparticle sorting device 100 moves the gate or its components. Similarly, when the user taps the rotate handle button, the bioparticle sorting device 100 rotates the gate or its components. Furthermore, movement or rotation operations of the selected gate or its components may be performed by buttons displayed in the operation button area 395 in the gate editing panel. This area shows movement handle buttons 357-1 to 357-4 for movement operations and rotation handle buttons 358-1 to 358-2 for rotation operations. The bioparticle sorting device 100 moves or rotates the gate or its components in response to these buttons being tapped. Area 395 may also include movement adjustment buttons 359-1 to 359-3 for adjusting the amount of movement by tapping the movement handle button or rotation handle button described above. The biological particle sorting device 100 changes the amount of movement in response to the tapping of these buttons. In area 395, three buttons are displayed: "Fine," "Mid," and "Rough," meaning the amount of movement can be adjusted in three stages, but the number of adjustment stages is not limited to these. The biological particle sorting device 100 may also display buttons for increasing or decreasing the amount of movement.

[0086] (2-3-2) Plot / Axis Editing Panel

[0087] The biological particle sorting device 100 may be configured to display a plot or axis editing panel (also called a "plot / axis editing panel button") for editing the display format and / or axes of the measurement data. For example, as shown in Figure 18A, the user taps the Plot / Axes Edit Panel button on the processing condition setting screen 300. In response to this tap, the biological particle sorting device 100 displays the Plot / Axes Edit Panel 361 on the screen, and in particular, in the measurement data display area, as shown in Figure 18B. As shown in Figure 18B, the Plot / Axes Edit Panel may be opaque, that is, it may be displayed in a way that hides the measurement data behind it. Alternatively, the Plot / Axes Edit Panel may be semi-transparent or transparent, that is, it may be displayed in a way that allows the measurement data behind it to be seen through the Plot / Axes Edit Panel. For example, as shown in Figure 18C, a semi-transparent Plot / Axes Edit Panel 362 may be displayed in the measurement data area. The semi-transparent nature of the panel allows for editing of the measurement data or its axes while viewing the measurement data behind the panel.

[0088] The plot / axis editing panel is an operation panel for editing measurement data and / or its axes. This plot / axis editing panel will be explained below with reference to Figure 19.

[0089] The plot / axis editing panel 361 shown on the left of Figure 19 includes a measurement data selection area 363 for selecting the measurement data to be edited. This measurement data selection area may include, for example, a drop-down menu 364 for selecting the measurement data to be edited. Other operation buttons for selecting the measurement data to be edited may also be displayed. The name of the selected measurement data may also be displayed in this area.

[0090] The plot / axis editing panel further includes a plot type selection area 365 for selecting the type of display format (e.g., plot type) for the measurement data. The plot type selection area includes a drop-down menu 366 for selecting, for example, the plot type of the measurement data to be edited. The drop-down menu may list one or more of the following: density plot, dot plot, histogram, and contour plot. In response to the user selecting a plot type from the drop-down menu, the bioparticle sorting device 100 changes the plot type of the measurement data to be edited to the selected plot type.

[0091] The plot / axis editing panel further includes an axis editing area 367 for editing axes. The axis editing area includes axis selection buttons 368 for selecting or changing the axis to be edited. For example, in the left of Figure 19, the axis to be edited is the X-axis, but when the user taps the axis selection button 368 to select the Y-axis, the bioparticle sorting device 100 changes the axis to be edited to the Y-axis, as shown on the right of Figure 19. Thus, the plot or axis editing panel may be configured to allow the user to select the axis to be edited. Furthermore, the method for changing the axis being operated on is not limited to the button-based method shown in Figure 19; for example, a tab-based method may also be used. This tab-based method will be explained with reference to Figure 25. In the left diagram of Figure 25, the X-axis tab is selected, meaning the X-axis tab is active. In the left diagram, the activity of the X-axis tab is indicated by the X-axis tab enclosed in a thick line and the inactive Y-axis tab enclosed in a thin line, but the method of representation is not limited to this. When the Y-axis tab in the left diagram is tapped, the display changes as shown in the right diagram of Figure 25. In the right diagram, the Y-axis tab is active. In the right diagram, the activity of the Y-axis tab is similarly indicated by the Y-axis tab enclosed in a thick line and the inactive X-axis tab enclosed in a thin line. Also, the content of the axis below the selected tab changes accordingly. In Figure 25, when the X-axis tab is active, it is indicated that the X-axis relates to forward scattered light (FSC-A). (Left figure), when the Y-axis tab is active, it is indicated that the Y-axis relates to backscattered light (BSC-A) (Right figure). Furthermore, the axis editing area may include a dropdown menu 369 for selecting the type of light or fluorescent dye to be used as the axis. Examples of the type of light include scattered light (forward scattered light, back scattered light, or side scattered light). In the case of a fluorescent dye, the target molecule to be captured by the antibody labeled with the fluorescent dye may be displayed. Furthermore, the axis editing area includes a setting area 370 for setting the axis format and / or numerical range. This area may be configured to allow setting the axis type (e.g., logarithmic or linear) and / or the axis numerical range (e.g., the maximum and / or minimum values ​​of the axis). The axis editing area may also include various operation buttons. For example, as shown in Figure 19, a copy button for copying the plot or axis type and / or numerical range settings, a paste button for pasting the plot or axis type and / or numerical range settings, a default button for returning the plot (or axis) settings to default, a zoom button for zooming the plot, and an auto-setting button for automatically setting the plot (or axis) may be displayed. All of these buttons may be displayed, or one or more of these buttons may be displayed in the area.

[0092] (2-3-3) Measurement data display area setting panel

[0093] The particle sorting device 100 may be configured to display a measurement data display area setting panel (hereinafter also referred to as the "worksheet setting panel") for adjusting the display settings of the measurement data display area (particularly the worksheet). For example, as shown in Figure 20A, when a user taps the Settings button on the processing condition setting screen 300, the biological particle sorting device 100 displays a group of buttons 371 related to various settings in the third display area. Next, as shown in Figure 20B, the user taps the Worksheet Settings button among these buttons. In response to this tap, as shown in Figure 20C, the biological particle sorting device 100 displays a Worksheet Settings panel 372 on the screen, particularly in the measurement data display area. As shown in the same figure, the Worksheet Settings panel may be opaque, that is, it may be displayed in a way that hides the measurement data behind it. Alternatively, the Worksheet Settings panel may be semi-transparent or transparent, that is, it may be displayed in a way that allows the measurement data behind it to be seen through the Worksheet Settings panel. For example, as shown in Figure 20D, a semi-transparent Worksheet Settings panel 373 may be displayed in the measurement data area. Because the panel is semi-transparent, it is possible to adjust the display settings of the worksheet while viewing the measurement data behind the panel.

[0094] The worksheet settings panel will be explained below with reference to Figure 21.

[0095] The worksheet settings panel 371 shown in Figure 21 includes an area 374 that displays the name of the worksheet to be configured. This area may display, for example, the name of the worksheet on the active tab.

[0096] Furthermore, as shown in the figure, the panel may also include a column setting area 375 for setting the number of columns of measurement data to be displayed in that area. In the figure, this area is labeled "Columns" and the number of columns is set to 3. That is, it is set so that three measurement data items are displayed in each row in the measurement data display area. When set in this way, for example as shown in Figure 20A, the bioparticle sorting device 100 displays the measurement data in three columns in the measurement data display area. In the figure, six measurement data items are displayed in a 3x2 arrangement, but as the number of measurement data items increases, the bioparticle sorting device 100 increases the number of rows while keeping the number of columns fixed. The blank spaces described in (2-2) above do not need to be counted in the number of columns displayed in the area. That is, when the user selects the mode for displaying blank spaces as described in (2-2) above, the biological particle sorting device 100 will be able to display in the measurement data display area a number of measurement data columns equal to the number of columns set in the column number setting area 375 plus the number of blank spaces. For example, if 3 is selected as the number of columns in the column number setting area 375 as shown in the figure, and one blank space is to be displayed in this mode, then four columns of measurement data will be able to be displayed in the measurement data display area in this mode. Thus, the biological particle sorting device 100 may be configured to increase the number of columns in the measurement data display area where measurement data can be placed, depending on the selected display mode for displaying the blank space. The increased columns may then be displayed as blank space.

[0097] The column number setting area 375 may include buttons for increasing or decreasing the number of columns of measurement data (one or more) displayed in the measurement data display area. In Figure 21, buttons 376-1 for increasing the number of columns and 376-2 for decreasing the number of columns are shown, but the method of displaying these buttons may be appropriately selected by those skilled in the art. In response to the user tapping these buttons, the biological particle sorting device 100 increases or decreases the number of columns of measurement data (and the number of columns displayed in area 375) placed in the measurement data display area.

[0098] Thus, a biological particle sorting device according to this disclosure may be configured such that the number of columns in which measurement data can be placed within the measurement data display area can be set. For example, the biological particle sorting device may be configured to display a setting panel for changing the number of such columns. It is desirable that the arrangement of measurement data used for biological particle sorting be appropriately modified according to, for example, the type of object to be sorted, the gate setting method, or the user's preference. A biological particle sorting device according to this disclosure can be configured in this way so that the arrangement of one or more measurement data can be adjusted as desired.

[0099] Furthermore, as shown in Figure 21, the panel may further include an area 377 for adjusting the number of events and / or the color of the measurement data displayed in the worksheet, and / or an operation area 378 for copying, pasting, or saving worksheet settings.

[0100] (2-4) Display process that overlays the contents of other display areas onto the measurement data display area.

[0101] As described above, the biological particle sorting apparatus according to this disclosure displays a second display area (measurement data display area), as well as a first display area (sorting operation control area) and / or a third display area (operation button area). Here, the number of measurement data displayed in the second display area is one or more, and in many cases, there are multiple. It is desirable that the measurement data be displayed larger, but it is also desirable that the first display area and / or the third display area be displayed appropriately for setting processing conditions and performing sorting operations. Therefore, in a preferred embodiment, the biological particle sorting device according to this disclosure is configured to overlay the display contents of the first display area and / or third display area onto the second display area in response to user operation. For example, the biological particle sorting device may be configured to overlay the display contents of the first or third display area onto the second display area when the user performs a predetermined screen operation, and not display the display contents in other cases. An example of such display processing is described below.

[0102] (2-4-1) Embodiment in which the content displayed in the first display area is superimposed on the second display area.

[0103] The first display area may display various numerical or measurement data acquired by the biological particle sorting device 100, as shown in Figure 22A. These data may also be displayed in a tabular format, as shown in Table 382-1, in area 381 which includes one or more buttons for controlling the sorting operation.

[0104] Table 382-1 shows the data acquired by the biological particle sorting device 100 during sorting by gate A. The table shows the name of the gate, the elapsed time since sorting began by the gate, the sorting rate of the gate, and the sorting efficiency of the gate, but the data displayed in the table is not limited to these. For example, the remaining time for sorting by the gate, the number of times the sorting operation has been performed by the gate (Sort Count), and the number of aborts at the gate (Abort Count) may also be displayed.

[0105] For example, a sorting process may be performed using multiple gates that are different from each other, and data related to the sorting process may be obtained for each gate. The table used to display this data may not fit within the first display area, or if the table is made to fit within the first display area, the text representing the data in the table may become extremely small, making it difficult for the user to read. Therefore, the biological particle sorting device 100 may be configured to expand and display the contents of the first display area onto the second display area. The biological particle sorting device 100 may display a data expansion button for performing such a display. For example, as shown in Figure 22A, the biological particle sorting device 100 may display a data expansion button 383-1 within the first display area.

[0106] As shown in Figure 22B, the user taps the data expansion button 383-1. In response to this tap, the bioparticle sorting device 100 displays Table 382-2, as shown in Figure 22C. The horizontal length of Table 382-2 is greater than the width of the first display area, and it is displayed overlapping the second display area. Table 382-2 displays not only the data acquired for gate A, but also the data acquired for gates B to D. By displaying Table 382-2 overlaid on the second display area in this way, the font size in the table can be increased, making it easier for the user to read the table data.

[0107] Furthermore, in Figure 22C, the data collapse button 383-2 is displayed in place of the data expand button 383-1. When the user taps the data collapse button 383-2, the bioparticle sorting device 100 collapses the table data and returns to the state shown in Figure 22A. Thus, the biological particle sorting device 100 can display data associated with items in the first display area by expanding it onto the second display area. Furthermore, the biological particle sorting device 100 may be configured to collapse the expanded data. This expansion and collapse process allows the user to view the data only when necessary, while maintaining the visibility of the measurement data in the second display area. In addition, it allows users to view the data only when needed on a screen with limited size.

[0108] (2-4-2) Embodiment in which the content displayed in the third display area is superimposed on the second display area.

[0109] As shown in Figure 23A, the third display area displays various operation buttons used in setting the preparative processing conditions. By reducing the area where these operation buttons are displayed, the second display area can be made larger, making the measurement data easier to view. Therefore, the biological particle preparative device 100 may be configured to expand and display the contents of the third display area onto the second display area. The biological particle preparative device 100 may display operation buttons that enable such expansion processing within the third display area. For example, as shown in Figure 23A, the biological particle preparative device 100 may display an expansion button 391 (View button) within the third display area. Next to the expansion button 391, an indicator 392 indicating that it is expandable may be provided. In the same figure, the Plot button, Gate button, and Settings button, which have the same indicator, are also expandable.

[0110] As shown in Figure 23B, the user taps the expand button 391. In response to this tap, the bioparticle sorting device 100 displays area 393, which contains the operation buttons, as shown in Figure 23C. Area 393 is displayed so as to overlap the second display area. Area 393 may be collapsed if the user taps the expand button 391 again. Thus, the biological particle sorting device 100 may be configured to expand an area containing one or more operation buttons associated with the operation buttons in the third display area onto the second display area. Furthermore, the biological particle sorting device 100 may be configured to fold up the expanded area. Through such expansion and folding processes, the group of operation buttons is displayed only when needed by the user, while maintaining the visibility of the measurement data in the second display area. In addition, the group of operation buttons can be viewed only when necessary on a screen with a limited size.

[0111] (3) Variant

[0112] While (1) and (2) above describe a bioparticle sorting device that performs sorting on bioparticles contained in a biological sample flowing through a channel (particularly bioparticles flowing in a line within the channel), this disclosure may also be applied to a bioparticle sorting device that performs sorting on a group of bioparticles existing in two or three dimensions. That is, the bioparticle sorting device of this disclosure may be configured to perform sorting on a group of bioparticles existing in two or three dimensions. Examples of such a bioparticle sorting device include a bioparticle sorting device that performs sorting on a group of bioparticles existing in wells arranged in two or three dimensions, a bioparticle sorting device that performs sorting on a group of bioparticles existing in two or three dimensions on an arbitrary support (e.g., a cell culture surface or a cell immobilization surface), and a bioparticle sorting device that performs sorting on a group of bioparticles forming a three-dimensional structure (e.g., biological tissue).

[0113] As an example of a biological particle sorting device that performs sorting on a group of biological particles present in the aforementioned well, we can cite a biological particle sorting device that performs sorting using a particle capture chip described in Japanese Patent Application Publication No. 2020-174598. As an example of a biological particle sorting device that performs sorting on a group of biological particles existing in two dimensions on any given surface, we can cite a biological particle sorting device that sorts specific biological particles from a group of biological particles (cells) immobilized on a certain surface via a decomposable linker (e.g., a photodegradable linker). These devices may be configured to acquire fluorescence signals or fluorescence images of biological particles using optical detectors, such as microscopes, and to identify the biological particles to be separated based on the acquired fluorescence signals or fluorescence images. These devices may be configured to remove only the biological particles thus identified from the well, or to release only the biological particles thus identified (for example, by cutting the linker that fixes the biological particles). These devices may be configured to perform the display processing described in (1) and (2) above.

[0114] 3. A second embodiment of the present disclosure (bioparticle sorting system)

[0115] This disclosure also provides a biological particle sorting system including a display unit that displays a measurement data display area on which one or more measurement data are displayed. The system may be configured to display a blank space in addition to the one or more measurement data within the measurement data display area, and to display the measurement data to be moved at the destination position when a user selects one of the one or more measurement data to be moved and one destination position in the blank space, and to display the position where the measurement data to be moved was located after the display position of the measurement data to be moved has been changed as a blank space. Such display processing may be performed by a biological particle sorting device or an information processing device included in the system. The biological particle sorting device may be as described in Section 2 above. The description of the information processing device in Section 2 above also applies to the information processing device. That is, this disclosure also provides an information processing device having a display unit in accordance with this disclosure.

[0116] An example of a biological particle sorting system in accordance with this disclosure will be described with reference to Figure 24. The figure shows an example configuration of the biological particle sorting system of this disclosure. The biological particle sorting system 400 shown in the figure includes a biological particle sorting device 401 that performs biological particle sorting processing, and a plurality of information processing devices 402a to 402c configured to operate the biological particle sorting device. The number of information processing devices included in the system is not limited to the three shown in the figure, but may be one or more. The plurality of information processing devices are connected to the biological particle sorting device, for example, via a network 403.

[0117] The information processing device 402a has a display unit as described in section 2 above. Through this display unit, the user sets the sorting processing conditions to be executed in the biological particle sorting device 401. The information processing device 402a shown in the figure operates as the information processing unit 102 as described in section 2 above. The information processing device 402a outputs the processing condition setting screen described in section 2 above to a display unit attached to or connected to the device. The user sets the sorting processing conditions to be executed in the biological particle sorting device 401 through this screen. That is, the information processing device 402a accepts input of sorting processing conditions through this screen. Then, the information processing device 402a causes the biological particle sorting device 401 to execute the sorting process according to the sorting processing conditions.

[0118] Furthermore, this disclosure may also take the following form. [1] It has a display unit that displays the measurement data display area, In a display mode in which one or more measurement data points are displayed in addition to a blank space within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After the display position of the moving target measurement data is changed, the position where the moving target measurement data was located is displayed as a blank space. A biological particle sorting device. [2] The biological particle sorting apparatus according to [1], wherein the one or more measurement data are displayed in a grid within the measurement data display area. [3] The biological particle sorting apparatus according to [1] or [2], wherein candidate position images indicating positions where measurement data can be placed are displayed in the blank space. [4] A biological particle sorting device according to any one of [1] to [3], wherein the arrangement configuration of measurement data other than the measurement data to be moved is not changed before and after the movement of the measurement data to be moved into the blank space. [5] The biological particle sorting device has multiple display modes. Depending on which display mode that displays the blank space is selected from among the plurality of display modes, the blank space will appear in the measurement data display area, or In accordance with the selection of a display mode that displays the blank space from among the plurality of display modes and the selection of the measurement data to be moved, the blank space is made to appear in the measurement data display area. A biological particle sorting device as described in any one of [1] to [4]. [6] A biological particle sorting device according to any one of [1] to [5], wherein the number of rows of positions in which measurement data can be placed within the measurement data display area is predetermined. [7] A biological particle sorting device according to any one of [1] to [6], configured to display a setting panel for changing the number of columns. [8] The biological particle sorting apparatus according to [6] or [7], wherein the number of columns is increased in accordance with the selection of a display mode that displays the blank space. [9] The biological particle sorting apparatus described in [8], wherein the increased number of columns is displayed as blank space.

[10] A biological particle sorting device according to any one of [7] to [9], wherein the aforementioned setting panel is displayed semi-transparently.

[11] It is configured to display a gate editing panel for editing the gates set in the measurement data. The gate editing panel is configured to allow the user to select the gate to be edited. A biological particle sorting device as described in any one of [1] to

[10] .

[12] The biological particle sorting apparatus according to

[11] , wherein the gate editing panel is configured to allow selection of the entire selected gate or components of the selected gate as the object to be edited.

[13] It is configured to display a plot or axis editing panel for editing the display format and / or axes of measurement data. The plot or axis editing panel is configured to allow selection of the axis to be edited. A biological particle sorting device as described in any one of [1] to

[12] .

[14] In addition to the measurement data display area, the display unit also displays a sorting operation control area that displays buttons for controlling the sorting operation by the biological particle sorting device. The system is configured to display the data associated with the aforementioned parsing operation control area on the aforementioned measurement data display area. A biological particle sorting device as described in any one of [1] to

[13] .

[15] In addition to the measurement data display area, the display unit also displays an operation button area for displaying one or more operation buttons used to set the sorting conditions. The system is configured such that, depending on the selection of any of the one or more operation buttons, the operation button area can be expanded and displayed on the measurement data display area. A biological particle sorting device as described in any one of [1] to

[14] .

[16] The biological particle sorting apparatus according to

[15] , wherein a button for selecting a display mode for displaying the blank space is displayed in the operation button area.

[17] The biological particle sorting device according to any one of [1] to

[16] , wherein the display unit is configured to allow touch input.

[18] It has a display unit that displays the measurement data display area, In a display mode in which one or more measurement data points are displayed in addition to a blank space within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After the display position of the moving target measurement data is changed, the position where the moving target measurement data was located is displayed as a blank space. A system for separating biological particles.

[19] It has a display unit that displays the measurement data display area, In a display mode in which one or more measurement data points are displayed in addition to a blank space within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After the display position of the moving target measurement data is changed, the position where the moving target measurement data was located is displayed as a blank space. Information processing device. [Explanation of Symbols]

[0119] 100 Bio-particle sorting device 101 Display section 102 Information Processing Unit

Claims

1. It has a display unit that displays the measurement data display area, It has multiple display modes, In the blank space display mode, in which a blank space is displayed in addition to one or more measurement data points within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After the display position of the moving target measurement data has been changed, the position where the moving target measurement data was located will be displayed as a blank space. The aforementioned blank space will not be displayed if a display mode other than the blank space display mode is selected. The system is configured to display a gate editing panel for editing the gates set in the measurement data. The gate editing panel is semi-transparent or transparent. The gate editing panel displays the measurement data in the measurement data display area so that the measurement data can be seen through the gate editing panel. A biological particle sorting device.

2. The biological particle sorting apparatus according to claim 1, wherein the one or more measurement data are displayed in a grid within the measurement data display area.

3. The biological particle sorting apparatus according to claim 1, wherein candidate position images indicating positions where measurement data can be placed are displayed in the blank space.

4. The biological particle sorting apparatus according to claim 1, wherein the arrangement configuration of measurement data other than the moving target measurement data is not changed before and after the moving of the moving target measurement data to the blank space.

5. Depending on which of the plurality of display modes is selected to display the blank space, the blank space is made to appear in the measurement data display area, or In accordance with the selection of a display mode that displays the blank space from among the plurality of display modes and the selection of the measurement data to be moved, the blank space is made to appear in the measurement data display area. The biological particle sorting apparatus according to claim 1.

6. The biological particle sorting device according to claim 1, wherein the number of rows of positions in which measurement data can be placed within the measurement data display area can be set.

7. The biological particle sorting apparatus according to claim 6, which is configured to display a setting panel for changing the number of columns.

8. The biological particle sorting apparatus according to claim 6, wherein the number of columns in the measurement data display area is increased in accordance with the selection of a display mode that displays the blank space.

9. The biological particle sorting apparatus according to claim 8, wherein the increased number of columns is displayed as blank space.

10. The biological particle sorting apparatus according to claim 7, wherein the setting panel is displayed semi-transparently.

11. The gate editing panel is configured to allow the selection of a gate to be edited. The biological particle sorting apparatus according to claim 1.

12. The biological particle sorting apparatus according to claim 11, wherein the gate editing panel is configured to allow selection of the entire selected gate or components of the selected gate as the object to be edited.

13. It is configured to display a plot or axis editing panel for editing the display format and / or axes of measurement data. The plot or axis editing panel is configured to allow selection of the axis to be edited. The biological particle sorting apparatus according to claim 1.

14. In addition to the measurement data display area, the display unit also displays a sorting operation control area that displays buttons for controlling the sorting operation by the biological particle sorting device. The system is configured to display the data associated with the aforementioned parsing operation control area on the aforementioned measurement data display area. The biological particle sorting apparatus according to claim 1.

15. In addition to the measurement data display area, the display unit also displays an operation button area for displaying one or more operation buttons used to set the sorting conditions. The system is configured such that, depending on the selection of any of the one or more operation buttons, the operation button area can be expanded and displayed on the measurement data display area. The biological particle sorting apparatus according to claim 1.

16. The biological particle sorting apparatus according to claim 15, wherein a button for selecting a display mode for displaying the blank space is displayed in the operation button area.

17. The biological particle sorting apparatus according to claim 1, wherein the display unit is configured to be touch-inputtable.

18. It has a display unit that displays the measurement data display area, It has multiple display modes, In the blank space display mode, in which a blank space is displayed in addition to one or more measurement data points within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After the display position of the moving target measurement data has been changed, the position where the moving target measurement data was located will be displayed as a blank space. The aforementioned blank space will not be displayed if a display mode other than the blank space display mode is selected. The system is configured to display a gate editing panel for editing the gates set in the measurement data. The gate editing panel is semi-transparent or transparent. The gate editing panel displays the measurement data in the measurement data display area so that the measurement data can be seen through the gate editing panel. A system for separating biological particles.

19. It has a display unit that displays the measurement data display area, It has multiple display modes, In the blank space display mode, in which a blank space is displayed in addition to one or more measurement data points within the measurement data display area, In response to the user selecting one of the one or more measurement data to be moved and one destination position in the blank space, the measurement data to be moved is displayed at the destination position. After the display position of the moving target measurement data has been changed, the position where the moving target measurement data was located will be displayed as a blank space. The aforementioned blank space will not be displayed if a display mode other than the blank space display mode is selected. The system is configured to display a gate editing panel for editing the gates set in the measurement data. The gate editing panel is semi-transparent or transparent. The gate editing panel displays the measurement data in the measurement data display area so that the measurement data can be seen through the gate editing panel. Information processing device.

Images