Mental disease determination method, program, mental disease determination apparatus, and mental disease determination system

Abstract

A first reference value that is a heart rate variability index of a normal person under a first auditory stimulus environment, a second reference value that is a heart rate variability index of the normal person under a second auditory stimulus environment that is different from the first auditory stimulus environment, a first comparative value that is a heart rate variability index of a user under the first auditory stimulus environment, and a second comparative value that is a heart rate variability index of the user under the second auditory stimulus environment are acquired. Comparison processing is performed among the first reference value, the second reference value, the first comparative value and the second comparative value to determine the possibility that a user has a mental disease.

Description

Method, program, device, and system for assessing mental illness

[0001] The present invention relates to a method, a program, an apparatus, and a system for determining a mental illness.

[0002] Patent Document 1 discloses a mental and physical state assessment device that includes an audio output unit for playing environmental music to a subject and a video output unit for showing an environmental video to the subject.

[0003] Patent Document 2 discloses a method for assessing a user's mental state by using questionnaire data and measurement data obtained by measuring changes in the high frequency (HF) and low frequency (LF) components of a user who is subjected to mental stress to determine whether the user is depressed.

[0004] Patent No. 6233776 Patent No. 6635507

[0005] The mental and physical state assessment device of Patent Document 1 requires pulse wave measurements before and after showing the subject images and listening to music, and also requires instructions to be displayed on the video output unit and operated by the subject. For these reasons, the mental and physical state assessment device of Patent Document 1 may not be easy to use.

[0006] The depression assessment method of Patent Document 2 requires the acquisition of questionnaire data and the measurement of changes in the heart rate variability index before, during, and after the user is subjected to a mental stress. For these reasons, the depression assessment method of Patent Document 2 may not be easy to use.

[0007] The present disclosure aims to provide a method, program, mental illness assessment method, and mental illness assessment system that are easier to use.

[0008] A method for diagnosing a mental illness according to one embodiment of the present disclosure includes obtaining a first reference value which is the heart rate variability index of a healthy individual in a first sound stimulation environment, a second reference value which is the heart rate variability index of the healthy individual in a second sound stimulation environment different from the first sound stimulation environment, a first comparison value which is the heart rate variability index of a user in the first sound stimulation environment, and a second comparison value which is the heart rate variability index of the user in the second sound stimulation environment, and performing a comparison process between the first reference value, the second reference value, the first comparison value, and the second comparison value to determine the possibility that the user has a mental illness.

[0009] A program according to one aspect of the present disclosure causes a computer to execute the determination method of the above aspect.

[0010] A mental illness assessment device according to one aspect of the present disclosure includes an acquisition unit that acquires a first reference value that is the heart rate variability index of a healthy subject in a first sound stimulation environment, a second reference value that is the heart rate variability index of the healthy subject in a second sound stimulation environment, a first comparison value that is the heart rate variability index of a user in the first sound stimulation environment, and a second comparison value that is the heart rate variability index of the user in the second sound stimulation environment; and a assessment unit that assesses the possibility that the user has a mental illness based on the acquired first reference value, second reference value, first comparison value, and second comparison value.

[0011] A mental illness assessment system according to one aspect of the present disclosure comprises: a assessment device according to the above aspect; an analysis device that analyzes the heart rate variability index of the healthy individual or the user; and a stimulation device that applies sound stimulation to the healthy individual or the user.

[0012] According to the assessment method of the above aspect, a method for assessing mental illness that can be used more easily can be realized.

[0013] According to the program of the above aspect, a method for assessing mental illness that can be used more easily can be executed by a computer.

[0014] According to the assessment device of the above aspect, it is possible to realize a mental illness assessment device that can be used more easily.

[0015] According to the mental illness determination system of the above aspect, the determination device makes it possible to realize a mental illness determination system that is easier to use.

[0016] 1 is a block diagram showing a mental illness assessment system according to an embodiment of the present disclosure. FIG. 1 is a graph showing an example of LF / HF of a healthy subject. FIG. 2 is a graph showing an example of LF / HF of a patient with bipolar 1 disorder. FIG. 3 is a graph showing an example of LF / HF of a patient with schizophrenia. FIG. 4 is a flowchart for explaining an example of a mental illness assessment method according to the present disclosure. FIG. 5 is a graph showing an example of LF / HF of a healthy subject. FIG. 6 is a graph showing an example of LF / HF of a patient with depression. FIG. 7 is a graph showing an example of LF / HF of a patient with bipolar disorder. FIG. 8 is a graph showing an example of LF / HF of a patient with bipolar 1 disorder. FIG. 9 is a graph showing an example of LF / HF of a patient with bipolar 2 disorder. FIG. 10 is a graph showing an example of LF / HF of a patient with schizophrenia. FIG. 11 is a graph showing an example of LF / HF of a healthy subject. FIG. 12 is a graph showing an example of LF / HF of a patient with depression. FIG. 13 is a graph showing an example of LF / HF of a patient with bipolar disorder. Graphs showing an example of LF / HF in a patient with schizophrenia, graphs showing an example of an analysis result using LF / HF and HF in combination, and graphs showing an example of an analysis result using HF and HR in combination.

[0017] An example of the present disclosure will be described below with reference to the accompanying drawings. In the following description, terms indicating specific directions or positions (e.g., terms including "upper," "lower," "right," and "left") are used as necessary. However, the use of these terms is intended to facilitate understanding of the present disclosure with reference to the drawings, and the meanings of these terms do not limit the technical scope of the present disclosure. Furthermore, the following description is merely exemplary in nature and is not intended to limit the present disclosure, its applications, or its uses. Furthermore, the drawings are schematic, and the proportions of the dimensions and the like do not necessarily correspond to reality.

[0018] 1, a mental illness assessment system 1 according to an embodiment of the present disclosure includes, as an example, a stimulation device 10, an analysis device 20, and a assessment device 30. In the mental illness assessment system 1, the analysis device 20 analyzes the heart rate variability (HRV) of a healthy subject and a user in an environment without sound stimulation and in an environment where sound stimulation is applied by the stimulation device 10, and the assessment device 30 determines the possibility that the user has a mental illness from the analyzed HRV.

[0019] The stimulation device 10, the analysis device 20, and the assessment device 30 may all be located in the same place, or may be located in different places. For example, the mental illness assessment system 1 can be configured so that the stimulation device 10 is built into a smartwatch and carried by the user, and the analysis device 20 and the assessment device 30 are located in an external device (e.g., a server) separate from the smartwatch. This allows for, for example, the following embodiments: A patient or examinee receives medical treatment from a doctor remotely. In this case, for example, a pulse wave is acquired by photographing the face or fingers with a home computer or smartphone camera. Sound stimulation is applied using the smartphone's microphone and call function or the computer's microphone and speaker. The assessment results by the assessment device 30 can be used as diagnostic assistance data for the doctor. The assessment results can be used in stress checks or health checks conducted at workplaces, schools, etc. In this case, for example, a pulse wave is acquired using a computer or smartphone camera at the workplace, school, etc., or an electrocardiogram is acquired by electrocardiogram measurement. Sound stimuli are applied using a smartphone's microphone and call function or a computer's microphone and speaker. Pulse waves are also acquired using, for example, earphones, glasses, or a ring (smart ring) with an embedded pulse wave sensor. Sound stimuli are applied using earphones, a smartphone's microphone and call function, or a computer's microphone and speaker. The assessment system is installed in a smartphone or smartwatch, and users use it to periodically (e.g., daily) check their own mental illness status. This not only allows users to manage their daily physical condition themselves, but also allows users to visually confirm the effects of various treatments using the system. The assessment system is applied to biofeedback, and the assessment index is used as an indicator to help users control their own mental illness status. The system is used for biofeedback in digital medical treatments (e.g., cognitive behavioral therapy and music therapy) administered via smartphones."Biofeedback" refers to the use of devices to measure information about unconscious processes (such as heart rate, blood pressure, or muscle tension) and present it to the individual in a form that they can be aware of. Through training, patients can understand why these changes in bodily function occur and learn how to control them, resulting in relief of symptoms such as pain, stress, insomnia, and headaches.

[0020] The stimulation device 10 applies sound stimulation to a healthy individual or a user, placing the healthy individual or user in a "sound stimulation environment." The "sound stimulation environment" includes a first sound stimulation environment and a second sound stimulation environment different from the first sound stimulation environment. The first sound stimulation environment does not apply sound stimulation, or does apply sound stimulation. The second sound stimulation environment applies sound stimulation. The sound stimulation applied in the second sound stimulation environment includes sound stimulation of a first frequency and sound stimulation of a second frequency higher than the first frequency. The user refers to a person who is determined by the determination device 30 to have or not have a mental illness, and the healthy individual refers to a person who does not suffer from a mental illness.

[0021] The analysis device 20 acquires and analyzes the heart rate variability index of a healthy subject or user in an environment where sound stimulation is present. The analysis device 20 is connected to the determination device 30, for example, wirelessly or via a wire. The heart rate variability index analyzed by the analysis device 20 is output to the determination device 30 via communication. Various heart rate variability indices are widely known (Front Public Health. 2017; 5: 258). Heart rate variability indices include, for example, LF (low frequency), HF (high frequency), LF / HF, and pNN50 (the percentage of heartbeats in which the difference between consecutive adjacent RR intervals (the interval between one QRS wave and the next QRS wave) exceeds 50 ms).

[0022] In this embodiment, the heart rate variability index is acquired and analyzed by, for example, a PPG sensor (optical heart rate sensor) or an ECG sensor (electrocardiogram sensor). In other words, the heart rate variability index is analyzed from a pulse wave or an electrocardiogram. The PPG sensor or ECG sensor may be provided in the analysis device 20, or may be provided in the stimulation device 10 or the determination device 30.

[0023] The determination device 30 includes an acquisition unit 31 and a determination unit 32. In this embodiment, the determination device 30 includes a CPU 301 that performs calculations, and a storage device 302 that stores programs required for the calculations and calculation results. Each of the acquisition unit 31 and the determination unit 32 is realized, for example, by the CPU 301 executing a predetermined program.

[0024] The acquiring unit 31 acquires a first reference value, a second reference value, a first comparison value, and a second comparison value. In the present embodiment, the acquiring unit 31 acquires a third reference value, a fourth reference value, a third comparison value, and a fourth comparison value from the analysis device 20 in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value. Each of the first reference value, the second reference value, the third reference value, the fourth reference value, the first comparison value, the second comparison value, the third comparison value, and the fourth comparison value is, for example, a value calculated from at least one of a plurality of indices including a high-frequency component of a heart rate variability index and a low-frequency component of a heart rate variability index, specifically, LF / HF, which is the ratio of the low-frequency component to the high-frequency component.

[0025] The first reference value, the second reference value, the third reference value, the fourth reference value, the first comparison value, the second comparison value, the third comparison value, and the fourth comparison value are, for example, the heart rate variability index of a healthy person or a user in the following sound stimulation environments. First reference value: the heart rate variability index of a healthy person in a first sound stimulation environment. For example, the heart rate variability index of a healthy person to which no sound stimulation is applied, or a healthy person to which a 30 Hz sound stimulation is applied. Second reference value: the heart rate variability index of a healthy person in a second sound stimulation environment, which is the heart rate variability index of a healthy person to which a sound stimulation of a first frequency or a second frequency is applied. For example, the heart rate variability index of a healthy person to which a 30 Hz or 40 Hz sound stimulation is applied. When the third reference value is used, the heart rate variability index of a healthy person to which a sound stimulation of a first frequency is applied. For example, the heart rate variability index of a healthy person to which a 30 Hz sound stimulation is applied. - Third reference value: the heart rate variability index of a healthy subject in a third sound stimulus environment different from the environments of the first and second sound stimuli, and the heart rate variability index of a healthy subject to which a sound stimulus of a second frequency is applied. For example, the heart rate variability index of a healthy subject to which a 40 Hz sound stimulus is applied. - Fourth reference value: the heart rate variability index of a healthy subject in a fourth sound stimulus environment different from the environments of the first to third sound stimuli, and the heart rate variability index of a healthy subject to which a sound stimulus of a first frequency and a sound stimulus of a second frequency are applied simultaneously. For example, the heart rate variability index of a healthy subject to which a 30 Hz sound stimulus and a 40 Hz sound stimulus are applied simultaneously. - First comparison value: the heart rate variability index of a user in an environment of a first sound stimulus. For example, the heart rate variability index of a user to which no sound stimulus is applied, or a user to which a 30 Hz sound stimulus is applied. Second comparison value: the heart rate variability index of the user in an environment of a second sound stimulus, and the heart rate variability index of a user to whom a sound stimulus of the first frequency or the second frequency is applied. For example, the heart rate variability index of a user to whom a sound stimulus of 30 Hz or 40 Hz is applied. When the third comparison value is used, the heart rate variability index of a user to whom a sound stimulus of the first frequency is applied. For example, the heart rate variability index of a user to whom a sound stimulus of 30 Hz is applied. Third comparison value: the heart rate variability index of a user in an environment of a third sound stimulus, and the heart rate variability index of a user to whom a sound stimulus of the second frequency is applied. For example, the heart rate variability index of a user to whom a sound stimulus of 40 Hz is applied.Fourth comparison value: the heart rate variability index of the user in a fourth sound stimulus environment, in which the sound stimulus of the first frequency and the sound stimulus of the second frequency are simultaneously applied. For example, the heart rate variability index of a healthy subject in which the sound stimulus of 30 Hz and the sound stimulus of 40 Hz are simultaneously applied.

[0026] The sound stimulation environments are not limited to environments in which no sound stimulation is applied, or environments in which one or both of 30 Hz and 40 Hz sound stimulation are applied, as long as they can determine the mental state of the subject, including the user and healthy individuals. The first sound stimulation environment is not limited to environments in which no sound stimulation is applied, but may also be environments in which sound stimulation of a predetermined frequency is applied. The second to fourth sound stimulation environments are preferably environments in which sound stimulation of 20 to 50 Hz is applied, more preferably environments in which sound stimulation of 25 to 45 Hz is applied, even more preferably environments in which sound stimulation of 27 to 43 Hz is applied, particularly preferably environments in which sound stimulation of 30 to 40 Hz is applied, and most preferably environments in which sound stimulation of 30 Hz or 40 Hz is applied. These sound stimulations can also be used in combination. For example, 30 Hz and 40 Hz sound stimulations can be applied simultaneously, as in the fourth reference value and fourth comparison value. The sound pressure of the specific frequency sound stimulus may be a sound pressure that can be heard by the subject and that can determine the subject's mental state. Furthermore, these sound stimuli may be, for example, either a click sound or a continuous sound, but are not particularly limited.

[0027] For example, the acquisition unit 31 may acquire, as each reference value, the heart rate variability index of a healthy subject measured each time the determination device 30 is used, or may acquire, as each reference value, the heart rate variability index of a healthy subject measured and stored during a previous use of the determination device 30. The acquisition unit 31 may acquire each reference value by selecting from the reference values ​​measured and accumulated each time the determination device 30 is used.

[0028] The determination unit 32 performs a comparison process between the first reference value, the second reference value, the first comparison value, and the second comparison value to determine the possibility that the user has a mental illness. Examples of mental illnesses that can be determined include states with symptoms such as depressive symptoms, manic symptoms, anxiety symptoms, or hallucinations and delusions. For example, depressive symptoms include major depressive disorder (MDD) or depressive episodes of bipolar disorder. An example of manic symptoms includes manic episodes of bipolar disorder. An example of anxiety symptoms includes anxiety disorders (generalized anxiety disorder, social anxiety disorder, etc.). An example of hallucinations and delusions includes schizophrenia. Furthermore, examples of mental illnesses that can be determined include mood disorders or schizophrenia. Mood disorders include depression or bipolar disorder, and bipolar disorder includes depressive episodes.

[0029] The possibility that the user has a mental illness is determined, for example, by the following comparison process: - Comparing the magnitude of the first reference value and the first comparison value; - Comparing the magnitude of the second reference value and the second comparison value; - Comparing the rate of change of the second reference value relative to the first reference value with the rate of change of the second comparison value relative to the first comparison value.

[0030] In this embodiment, the determination unit 32 determines whether the user has a mental illness using a third reference value, a fourth reference value, a third comparison value, and a fourth comparison value in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value. In this case, whether the user has a mental illness is determined, for example, by the following comparison process in addition to the above-described comparison process method: - Comparing the magnitudes of the third reference value and the third comparison value; - Comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value; - Comparing the magnitudes of the fourth reference value and the fourth comparison value; - Comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value; - Comparing the magnitudes of the third reference value and the third comparison value, and comparing the magnitudes of the fourth reference value and the fourth comparison value. - Compare the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value, and compare the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value.

[0031] For example, under the environments of "no sound stimulation," "application of 30 Hz sound stimulation," "application of 40 Hz sound stimulation," and "application of 30 Hz + 40 Hz sound stimulation," the LF / HF of "patients with individual psychiatric disorders (bipolar I disorder and schizophrenia)" and "healthy subjects" show trends as shown in Figures 2 to 4. In Figures 2 to 4, the first reference value, second reference value, third reference value, fourth reference value, first comparison value, second comparison value, third comparison value, and fourth comparison value are the heart rate variability indexes as follows: First reference value: heart rate variability index of a healthy subject to no sound stimulation. Second reference value: heart rate variability index of a healthy subject to which a 30 Hz sound stimulation is applied. Third reference value: heart rate variability index of a healthy subject to which a 40 Hz sound stimulation is applied. Fourth reference value: heart rate variability index of a healthy subject to which a 30 Hz sound stimulation and a 40 Hz sound stimulation are simultaneously applied. First comparison value: Heart rate variability index of a user to which no sound stimulation is applied. Second comparison value: Heart rate variability index of a user to which a 30 Hz sound stimulation is applied. Third comparison value: Heart rate variability index of a user to which a 40 Hz sound stimulation is applied. Fourth comparison value: Heart rate variability index of a healthy subject to which a 30 Hz sound stimulation and a 40 Hz sound stimulation are simultaneously applied.

[0032] FIG. 2 shows the LF / HF of "healthy subjects." FIG. 3 shows the LF / HF of "patients with bipolar I disorder." FIG. 4 shows the LF / HF of "patients with schizophrenia." As an example, FIGS. 2 to 4 show LF / HF calculated under the following conditions. Pulse wave data were obtained from 15 psychiatric patients (15 with schizophrenia and 11 with bipolar I disorder) who were hospitalized or outpatients, as well as 15 healthy subjects, using a PPG sensor under the following conditions: "no sound stimulation," "application of 30 Hz sound," "application of 40 Hz sound," and "application of 30 Hz + 40 Hz sound." In FIGS. 3 and 4 , the LF / HF of each patient is the average value of the LF / HF of all patients whose pulse wave data was obtained. For example, the LF / HF of a depressed patient is the average value of the LF / HF of all depressed patients whose pulse wave data was obtained. Each sound stimulus was a click sound with a sound pressure of 70 dB at a frequency corresponding to the sound stimulus (i.e., 30 Hz, 40 Hz, or 30 Hz + 40 Hz), with 150 sets (150 seconds in total) consisting of 500 msec of sound stimulus followed by 500 msec of no sound stimulus. The acquired pulse wave data was analyzed using the analyzer 20 for various heart rate variability parameters (LF, HF, LF / HF, pNN50, etc.). For HF and LF, power spectrum analysis was performed on the frequency components of the pulse wave periodic fluctuations in the acquired pulse wave data (RR interval), and the frequency components were classified into three frequency ranges: VLF: low-frequency component (0-0.05 Hz), LF: intermediate-frequency component (0.05-0.20 Hz), and HF: high-frequency component (0.20-0.35 Hz). LF / HF was calculated from the classified LF and HF.

[0033] (Patients with bipolar 1 disorder) As shown in Figures 2 and 3, "patients with bipolar 1 disorder" tend to have lower LF / HF than "healthy individuals" under any of the following conditions: "no sound stimulation," "application of 30 Hz sound stimulation," "application of 40 Hz sound stimulation," and "application of 30 Hz + 40 Hz sound stimulation." Under the conditions of "application of 40 Hz sound stimulation" and "application of 30 Hz + 40 Hz sound stimulation," "healthy individuals" tend to have higher LF / HF compared to "no sound stimulation," while "patients with bipolar 1 disorder" tend to have approximately the same LF / HF compared to "no sound stimulation." As shown in Figures 2 and 3, "patients with bipolar 1 disorder" have lower LF / HF than "healthy individuals" under any of the conditions of "no sound stimulation," "application of 30 Hz sound stimulation," "application of 40 Hz sound stimulation," and "application of 30 Hz + 40 Hz sound stimulation."

[0034] For example, referring to FIGS. 2 and 3 , if any one, any two or more, or all of the following conditions are met, it is determined that "the user may have bipolar I disorder." The first comparison value is lower than the first reference value. The second comparison value is lower than the second reference value. The third comparison value is lower than the third reference value. The fourth comparison value is lower than the fourth reference value. The rate of change of the third comparison value relative to the first comparison value is smaller than the rate of change of the third reference value relative to the first reference value. The rate of change of the fourth comparison value relative to the first comparison value is smaller than the rate of change of the fourth reference value relative to the first reference value. The rate of change of the third comparison value relative to the second comparison value is smaller than the rate of change of the third reference value relative to the second reference value. The rate of change of the fourth comparison value relative to the second comparison value is smaller than the rate of change of the fourth reference value relative to the second reference value.

[0035] In the judgment, it is believed that the possibility that the user has bipolar I disorder can be more accurately judged by placing greater importance on the results of the following comparison processes: "Comparison of the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value" "Comparison of the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value" "Comparison of each reference value with each comparison value"

[0036] (Schizophrenia patients) As shown in Figures 2 and 4, there is no significant difference between "schizophrenia patients" and "healthy individuals" in the "no sound stimulation" and "30 Hz sound stimulation" environments, but the LF / HF tends to be lower than that of "healthy individuals" in the "40 Hz sound stimulation" and "30 Hz + 40 Hz sound stimulation" environments. In the "40 Hz sound stimulation" and "30 Hz + 40 Hz sound stimulation" environments, the "healthy individuals" tend to have a higher LF / HF compared to "no sound stimulation," while the "schizophrenia patients" tend to have approximately the same LF / HF compared to "no sound stimulation." As shown in Figures 3 and 4, the "schizophrenia patients" have a higher LF / HF than the "bipolar I disorder patients" in the "no sound stimulation" environment.

[0037] For example, referring to FIGS. 2 to 4, if any one, more than one, or all of the following conditions are met, it is determined that "the user may have schizophrenia." There is no significant difference between the first comparison value and the first reference value. There is no significant difference between the second comparison value and the second reference value. The third comparison value is lower than the third reference value. The fourth comparison value is lower than the fourth reference value. The rate of change of the third comparison value relative to the first comparison value is smaller than the rate of change of the third reference value relative to the first reference value. The rate of change of the fourth comparison value relative to the first comparison value is smaller than the rate of change of the fourth reference value relative to the first reference value. The rate of change of the third comparison value relative to the second comparison value is smaller than the rate of change of the third reference value relative to the second reference value. The rate of change of the fourth comparison value relative to the second comparison value is smaller than the rate of change of the third reference value relative to the second reference value. The rate of change of the fourth comparison value relative to the second comparison value is smaller than the rate of change of the fourth reference value relative to the second reference value.

[0038] In the judgment, it is believed that the possibility that the user has schizophrenia can be more accurately judged by placing greater importance on the results of the following comparison processes: "Comparison of the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value" "Comparison of the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value" "Comparison of the first reference value with the first comparison value" "Comparison of the second reference value with the second comparison value"

[0039] Next, a method for determining whether a person has a mental illness will be described with reference to Fig. 5. Here, as an example, a case will be described in which the possibility of a mental illness is determined by comparing the first reference value, the second reference value, the first comparison value, and the second comparison value.

[0040] As shown in FIG. 5, the stimulation device 10 is used to place the user in a first sound stimulation environment and a second sound stimulation environment (step S1), and pulse wave data of the user is acquired (step S2).

[0041] When the user's pulse wave data is acquired, the analysis device 20 analyzes the heart rate variability index from the acquired pulse wave data, and the acquisition unit 31 of the determination device 30 acquires the first reference value, the second reference value, the first comparison value, and the second comparison value, which are the analyzed heart rate variability index (step S3).

[0042] After the first reference value, the second reference value, the first comparison value, and the second comparison value are acquired, the judgment unit 32 of the judgment device 30 compares the acquired first reference value, the second reference value, the first comparison value, and the second comparison value to determine whether a predetermined condition is satisfied (step S4). The predetermined condition is set individually depending on the mental disorder to be assessed. For example, the predetermined condition is satisfied when one, two, or all of the following three conditions are satisfied: "The first comparison value is lower than the first reference value," "The second comparison value is lower than the second reference value," and "The rate of change of the second comparison value relative to the first comparison value is small."

[0043] If it is determined that the predetermined condition is satisfied, the determination unit 32 determines that there is a possibility of a mental illness (step S5). On the other hand, if it is determined that the predetermined condition is not satisfied, the determination unit 32 determines that there is no possibility of a mental illness (step S6). If the determination unit 32 determines that there is a possibility that the user has a mental illness, the method for determining whether or not a mental illness exists ends.

[0044] The method for diagnosing a mental illness of the present disclosure can achieve the following effects.

[0045] The mental illness assessment method of the present disclosure includes obtaining a first reference value, which is the heart rate variability index of a healthy individual in a first sound stimulation environment; a second reference value, which is the heart rate variability index of the healthy individual in a second sound stimulation environment different from the first sound stimulation environment; a first comparison value, which is the heart rate variability index of the user in the first sound stimulation environment; and a second comparison value, which is the heart rate variability index of the user in the second sound stimulation environment. A comparison process is performed between the first reference value, the second reference value, the first comparison value, and the second comparison value to determine the possibility that the user has a mental illness. This configuration allows for a more convenient mental illness assessment method. The mental illness assessment method of the present disclosure does not require the user to view an image during use, thereby reducing the burden on the user and enabling use by subjects with visual impairments as well as those without visual impairments. The mental illness assessment method of the present disclosure is not affected by at least the user's preferences for images, thereby reducing constraints on the assessment method.

[0046] As described above, the method for assessing mental illness of the present disclosure can be used to assess various mental illnesses, for example, to assess the possibility of bipolar I disorder and schizophrenia. Furthermore, since the possibility of a mental illness is assessed from the user's heart rate variability index in an environment where sound stimulation is provided, the burden on the user during assessment is low.

[0047] The program disclosed herein allows a computer to execute a method for assessing mental illness that is easier to use.

[0048] The assessment device 30 can realize a mental illness assessment device that is easier to use.

[0049] The mental illness determination system 1 can realize a mental illness determination system that is easier to use by using the determination device 30.

[0050] The mental illness assessment method, program, mental illness assessment device 30, and mental illness assessment system 1 can optionally employ one or more of the following configurations. That is, if one or more of the following configurations are included in the above-described embodiment, they can be optionally deleted, and if they are not included in the above-described embodiment, they can be optionally added. By employing such a configuration, it is possible to more reliably determine the possibility that the user has a mental illness.

[0051] Each of the first reference value, the second reference value, the first comparison value, and the second comparison value is a value calculated from at least one of a plurality of indices including a high-frequency component of a heart rate variability index and a low-frequency component of a heart rate variability index.

[0052] Each of the first reference value, the second reference value, the first comparison value, and the second comparison value is LF / HF, which is the ratio of low frequency components to high frequency components.

[0053] Heart rate variability indices are analyzed from the pulse wave or electrocardiogram.

[0054] The magnitudes of the first reference value and the first comparison value are compared to determine the possibility that the user has a mental illness.

[0055] The magnitude of the second reference value and the second comparison value are compared to determine the possibility that the user has a mental illness.

[0056] The rate of change of the second reference value relative to the first reference value is compared with the rate of change of the second comparison value relative to the first comparison value to determine the possibility that the user has a mental illness.

[0057] In the first sound stimulus environment, either no sound stimulus is applied or a sound stimulus is applied, and in the second sound stimulus environment, a sound stimulus is applied.

[0058] The sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency. The second reference value is a heart rate variability index of a healthy subject to which the sound stimulation of the first frequency is applied, and the second comparison value is a heart rate variability index of a user to which the sound stimulation of the first frequency is applied. In addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is a heart rate variability index of a healthy subject to which the sound stimulation of the second frequency is applied, and a third comparison value which is a heart rate variability index of a user to which the sound stimulation of the second frequency is applied are obtained. A comparison process is performed between the first reference value, the second reference value, the third reference value, the first comparison value, the second comparison value, and the third comparison value to determine the possibility that the user has a mental illness.

[0059] The magnitudes of the third reference value and the third comparison value are compared to determine the possibility that the user has a mental illness.

[0060] The rate of change of the third reference value relative to the first reference value is compared with the rate of change of the third comparison value relative to the first comparison value to determine the possibility that the user has a mental illness.

[0061] The sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency. The second reference value is a heart rate variability index of a healthy subject to which the sound stimulation of the first frequency is applied, and the second comparison value is a heart rate variability index of a user to which the sound stimulation of the first frequency is applied. In addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a fourth reference value is obtained which is a heart rate variability index of a healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value is obtained which is a heart rate variability index of a user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied. A comparison process is performed between the first reference value, the second reference value, the fourth reference value, the first comparison value, the second comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

[0062] The possibility that the user has a mental illness is determined by comparing the magnitudes of the fourth reference value and the fourth comparison value.

[0063] The rate of change of the fourth reference value relative to the first reference value is compared with the rate of change of the fourth comparison value relative to the first comparison value to determine the possibility that the user has a mental illness.

[0064] The sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency. The second reference value is a heart rate variability index of a healthy subject to which the sound stimulation of the first frequency is applied, and the second comparison value is a heart rate variability index of a user to which the sound stimulation of the first frequency is applied. In addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value is a heart rate variability index of a healthy subject to which the sound stimulation of the second frequency is applied, a third comparison value is a heart rate variability index of a user to which the sound stimulation of the second frequency is applied, a fourth reference value is a heart rate variability index of a healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value is a heart rate variability index of a user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied. A comparison process is performed between the first reference value, the second reference value, the third reference value, the fourth reference value, the first comparison value, the second comparison value, the third comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

[0065] The magnitude of the third reference value is compared with the third comparison value, and the magnitude of the fourth reference value is compared with the fourth comparison value to determine whether or not the user is likely to have a mental illness.

[0066] The rate of change of the third reference value relative to the first reference value is compared with the rate of change of the third comparison value relative to the first comparison value, and the rate of change of the fourth reference value relative to the first reference value is compared with the rate of change of the fourth comparison value relative to the first comparison value, thereby determining the possibility that the user has a mental illness.

[0067] The sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of a healthy subject to which the sound stimulation of the second frequency is applied, and the second comparison value is a heart rate variability index of a user to which the sound stimulation of the second frequency is applied.

[0068] The psychiatric disorder is a mood disorder or schizophrenia.

[0069] The mood disorder is depression or bipolar disorder.

[0070] The bipolar disorder is a depressive episode.

[0071] The mental illness assessment method, assessment device 30, and mental illness assessment system 1 can also be configured as follows.

[0072] The possibility that a user has a mental illness can also be determined using a statistical regression model. That is, the "comparison process" performed between the first reference value, the second reference value, the third reference value, the fourth reference value, the first comparison value, the second comparison value, the third comparison value, and the fourth comparison value includes a statistical regression model such as logistic regression analysis. The statistical regression model is constructed by mechanically selecting variables (e.g., selecting up to three variables using a mechanical variable gradation method) from various variable sets (e.g., LF, HF, LF / HF, etc.) obtained from an analysis of pulse wave data from patients with a mental illness (e.g., depression or bipolar II disorder). For variable selection, for example, the variable selection method described in "Loann, David, Denis, Desboulet et al: A Review on Variable Selection in Regression Analysis. Economics 6, 45 (2018)" can be used.

[0073] Each of the mental illness assessment methods and assessment devices 30 may be configured to determine the possibility that a user has a mental illness by performing a comparison process using at least a first reference value, a second reference value, a first comparison value, and a second comparison value. For example, the comparison process may be performed using a third reference value, a fourth reference value, a third comparison value, and a fourth comparison value, or may be performed using a fifth reference value different from the first to fourth reference values ​​and a fifth comparison value different from the first to fourth comparison values ​​in addition to the first to fourth reference values ​​and the first to fourth comparison values.

[0074] The reference values ​​and comparison values ​​are not limited to LF / HF, and may be other parameters.

[0075] The heart rate variability index can be obtained from pulse wave data. Pulse wave data can also be obtained by the following methods, for example: - Using microwave radar. - Using a pulse oximeter. Pulse wave data is obtained from arterial blood oxygen saturation (SpO2). - Using thermography. Pulse wave data is obtained from temperature changes on the face or neck. - Using a smart watch that can measure body surface temperature. Pulse wave data is obtained from temperature changes on the body surface. - Using earphones that can measure temperature inside the ear. Pulse wave data is obtained using a vital sensing sensor or the like, or from temperature changes inside the ear.

[0076] Analysis of various heart rate variability parameters (LF, HF, LF / HF, pNN50, etc.) can be performed using power spectrum analysis. Furthermore, to observe changes over time in various heart rate variability parameters, evaluation can be performed using the moving average method. As an example, LF / HF values ​​analyzed under the following conditions, with pulse wave data for 60 seconds or 150 seconds shifted every second, are shown in Figures 6 to 17 for the 60 seconds or 150 seconds immediately following each sound stimulus. Figures 6 and 12 show the average LF / HF values ​​for "healthy subjects." Figures 7 and 13 show the LF / HF values ​​for "depression." Figures 8 and 14 show the LF / HF values ​​for "bipolar disorder (BP1+BP2)." Figures 9 and 15 show the LF / HF values ​​for "bipolar 1 disorder (BP1)." Figures 10 and 16 show the LF / HF values ​​for "bipolar 2 disorder (BP2)." Figures 11 and 17 show the LF / HF values ​​for "schizophrenia." Pulse wave data were obtained using a PPG sensor from psychiatric patients (30 with depression, 11 with bipolar I disorder, 21 with bipolar II disorder, and 32 with schizophrenia) who were hospitalized or outpatients, as well as from healthy individuals (25 individuals) under the following conditions: no sound stimulation, 30 Hz sound stimulation, 40 Hz sound stimulation, and 30 Hz + 40 Hz sound stimulation. Each sound stimulation was a click sound with a sound pressure of 70 dB at a frequency corresponding to the corresponding sound stimulation (i.e., 30 Hz, 40 Hz, or 30 Hz + 40 Hz), with one set consisting of 500 msec of stimulation followed by 500 msec of no stimulation. The healthy individuals or users were given 150 sets (150 seconds in total) of stimulation. The pulse wave data for 150 seconds after each sound stimulus (600 seconds in total) was subjected to power spectrum analysis. The LF / HF of the pulse wave data for 150 seconds immediately after each sound stimulus is shown in Figures 6 to 11, and the LF / HF of the pulse wave data for 60 seconds immediately after each sound stimulus is shown in Figures 12 to 17. The measurement time period is not limited to 150 or 60 seconds; any number of seconds can be selected. The possibility of a mental illness may be determined, for example, using either the 150-second measurement result or the 60-second measurement result, or both the 150-second and 60-second measurement results. Various heart rate variability parameters (LF, HF, LF / HF, pNN50, etc.) were analyzed using the acquired pulse wave data by the analysis device 20.For HF and LF, the frequency components of the periodic fluctuations of the pulse wave in the acquired pulse wave data (RR interval) were analyzed and classified into three frequency ranges: VLF: low frequency components (0-0.05 Hz), LF: intermediate frequency components (0.05-0.20 Hz), and HF: high frequency components (0.20-0.35 Hz). LF / HF was calculated from the classified LF and HF.

[0077] The possibility of a mental illness is not limited to being determined using only LF / HF, but may also be determined using a combination of LF / HF and other indices, or a combination of multiple indices other than LF / HF. FIG. 18 shows an example of an analysis result using a combination of LF / HF and HF, and FIG. 19 shows an example of an analysis result using a combination of HF and HR (heart rate; the average value of all heart rates over a predetermined period (e.g., 1 minute, 2 minutes, 3 minutes, 4 minutes, or 5 minutes)). As shown in FIGS. 18 and 19, the combination of LF / HF and HF, or HF and HR, makes it possible to distinguish between "depression" and "bipolar disorder."

[0078] 18 shows an example of heart rate variability parameters for a "healthy subject" and a "depressed subject," where HF without sound stimulation and LF / HF with 40 Hz sound applied (for 60 seconds) are used as indices, with the cutoff value CF1 set to, for example, HF: 550, LF / HF: 1.2. In FIG. 18, the analysis results for the "healthy subject" are shown with open circles, and the analysis results for the "depressed subject" are shown with closed circles. In this case, the sensitivity was 80%, and the specificity was 70%.

[0079] FIG. 19 shows an example in which the cutoff value CF2 is set to, for example, "HR: 75, HF: -1000," using the HR of a "healthy subject" and a patient with "bipolar disorder" when "a 40 Hz sound is applied" and the HF of a "40 Hz sound is applied (for 30 seconds)" as indicators. In FIG. 19, the analysis results for the "healthy subject" are shown with white circles, and the analysis results for the "patient with bipolar disorder" are shown with black circles. In this case, the sensitivity was 75%, and the specificity was 76%.

[0080] The "cutoff value" is the boundary value that distinguishes between patients with a specific disease and those without, and is also called the pathological condition discrimination value. "Sensitivity" indicates the proportion of positive results among those with the disease, and "specificity" indicates the proportion of negative results among those without the disease.

[0081] Various embodiments of the present disclosure have been described in detail above with reference to the drawings. Finally, various aspects of the present disclosure will be described.

[0082] The first aspect of the judgment method involves obtaining a first reference value which is the heart rate variability index of a healthy person in a first sound stimulation environment, a second reference value which is the heart rate variability index of the healthy person in a second sound stimulation environment different from the first sound stimulation environment, a first comparison value which is the heart rate variability index of the user in the first sound stimulation environment, and a second comparison value which is the heart rate variability index of the user in the second sound stimulation environment, and performing a comparison process between the first reference value, the second reference value, the first comparison value, and the second comparison value to judge the possibility that the user has a mental illness.

[0083] The second aspect of the determination method is the determination method of the first aspect, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is a value calculated from at least one of a plurality of indices including a high-frequency component of a heart rate variability index and a low-frequency component of a heart rate variability index.

[0084] A third aspect of the determination method is the second aspect of the determination method, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is LF / HF, which is the ratio of the low frequency component to the high frequency component.

[0085] A fourth aspect of the determination method is the determination method of any one of the first to third aspects, wherein the heart rate variability index is analyzed from a pulse wave or an electrocardiogram.

[0086] The determination method of the fifth aspect is the determination method of any one of the first to fourth aspects, in which the possibility that the user has a mental illness is determined by comparing the magnitude of the first reference value and the magnitude of the first comparison value.

[0087] The determination method of the sixth aspect is the determination method of any one of the first to fifth aspects, in which the possibility that the user has a mental illness is determined by comparing the magnitude of the second reference value and the magnitude of the second comparison value.

[0088] The seventh aspect of the determination method is the determination method of any one of the first to sixth aspects, in which the possibility that the user has a mental illness is determined by comparing the rate of change of the second reference value relative to the first reference value with the rate of change of the second comparison value relative to the first comparison value.

[0089] The judgment method of the eighth aspect is the judgment method of any one of the first to seventh aspects, wherein in the first sound stimulation environment, no sound stimulation is applied or a sound stimulation is applied, and in the second sound stimulation environment, a sound stimulation is applied.

[0090] The determination method of a ninth aspect is the determination method of the eighth aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency; the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency is applied; the second comparison value is a heart rate variability index of the user to which the sound stimulation of the first frequency is applied; and in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is the heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied and a third comparison value which is the heart rate variability index of the user to which the sound stimulation of the second frequency is applied are obtained; and a comparison process is performed between the first reference value, the second reference value, the third reference value, the first comparison value, the second comparison value, and the third comparison value to determine the possibility that the user has a mental illness.

[0091] A tenth aspect of the determination method is the ninth aspect of the determination method, further comprising: comparing the magnitudes of the third reference value and the third comparison value to determine the possibility that the user has a mental illness.

[0092] The determination method of the eleventh aspect is the determination method of the ninth or tenth aspect, in which the possibility that the user has a mental illness is determined by comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value.

[0093] The determination method of a twelfth aspect is the determination method of the eighth aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency; the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency is applied; the second comparison value is a heart rate variability index of the user to which the sound stimulation of the first frequency is applied; and in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a fourth reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is a heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied are obtained; and a comparison process is performed between the first reference value, the second reference value, the fourth reference value, the first comparison value, the second comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

[0094] The determination method of a thirteenth aspect is the determination method of the twelfth aspect, further comprising: comparing the magnitudes of the fourth reference value and the fourth comparison value to determine the possibility that the user has a mental illness.

[0095] The determination method of the 14th aspect is the determination method of the 12th or 13th aspect, in which the possibility that the user has a mental illness is determined by comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value.

[0096] A determination method of a 15th aspect is the determination method of the 8th aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency is applied, the second comparison value is a heart rate variability index of the user to which the sound stimulation of the first frequency is applied, and in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is the heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, a third comparison value which is the heart rate variability index of the user to which the sound stimulation of the second frequency is applied, a fourth reference value which is the heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is the heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, are obtained. A comparison process is performed between the first reference value, the second reference value, the third reference value, the fourth reference value, the first comparison value, the second comparison value, the third comparison value and the fourth comparison value to determine the possibility that the user has a mental illness.

[0097] The determination method of the 16th aspect is the determination method of the 15th aspect, in which the magnitude of the third reference value and the third comparison value are compared, and the magnitude of the fourth reference value and the fourth comparison value are compared to determine whether the user is likely to have a mental illness.

[0098] The determination method of the 17th aspect is the determination method of the 15th or 16th aspect, in which the possibility that the user has a mental illness is determined by comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value, and comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value.

[0099] The determination method of the 18th aspect is the determination method of the 8th aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, and the second comparison value is a heart rate variability index of the user to which the sound stimulation of the second frequency is applied.

[0100] A nineteenth aspect of the determination method is the determination method of any one of the first to eighteenth aspects, wherein the mental disorder is a state in which symptoms of depression, mania, anxiety, or hallucinations / delusions are present.

[0101] A twentieth aspect of the determination method is the determination method of any one of the first to eighteenth aspects, wherein the mental disorder is a mood disorder, an anxiety disorder, or schizophrenia.

[0102] A 21st aspect of the determination method is the determination method of any one of the 1st to 18th aspects, wherein the mental disease is a mood disorder or schizophrenia.

[0103] A 22nd aspect of the present invention relates to the method for determining a mood disorder according to the 21st aspect, wherein the mood disorder is depression or bipolar disorder.

[0104] A 23rd aspect of the present invention relates to the method for determining bipolar disorder according to the 22nd aspect, wherein the bipolar disorder is a depressive episode.

[0105] A program according to a twenty-fourth aspect causes a computer to execute any one of the determination methods according to the first to twenty-third aspects.

[0106] The determination device of the 25th aspect comprises an acquisition unit that acquires a first reference value which is the heart rate variability index of a healthy person in an environment of a first sound stimulation, a second reference value which is the heart rate variability index of the healthy person in an environment of a second sound stimulation, a first comparison value which is the heart rate variability index of the user in the environment of the first sound stimulation, and a second comparison value which is the heart rate variability index of the user in the environment of the second sound stimulation; and a determination unit that determines the possibility that the user has a mental illness based on the acquired first reference value, second reference value, first comparison value, and second comparison value.

[0107] A 26th aspect of the determination device is the 25th aspect of the determination device, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is a value calculated from at least one of a plurality of indices including a high-frequency component of a heart rate variability index and a low-frequency component of a heart rate variability index.

[0108] A 27th aspect of the determination device is the 26th aspect of the determination device, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is LF / HF, which is the ratio of the low frequency component to the high frequency component.

[0109] A determination device of a 28th aspect is the determination device of any one of the 25th to 27th aspects, wherein the acquisition unit acquires the heart rate variability index analyzed from a pulse wave or an electrocardiogram.

[0110] The determination device of the 29th aspect is the determination device of any of the 25th to 28th aspects, wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of the first reference value and the magnitude of the first comparison value.

[0111] The determination device of the 30th aspect is the determination device of any of the 25th to 29th aspects, wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of the second reference value and the second comparison value.

[0112] The judgment device of the 31st aspect is the judgment device of any of the 25th to 30th aspects, wherein the judgment unit judges the possibility that the user has a mental illness by comparing the rate of change of the second reference value relative to the first reference value with the rate of change of the second comparison value relative to the first comparison value.

[0113] The determination device of the 32nd aspect is the determination device of any one of the 25th to 31st aspects, wherein in the first sound stimulation environment, no sound stimulation is applied or a sound stimulation is applied, and in the second sound stimulation environment, a sound stimulation is applied.

[0114] A 33rd aspect of the determination device is the determination device of the 32nd aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency; the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency is applied; the second comparison value is a heart rate variability index of the user to which the sound stimulation of the first frequency is applied; the acquisition unit acquires, in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value that is the heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, and a third comparison value that is the heart rate variability index of the user to which the sound stimulation of the second frequency is applied; and the determination unit performs a comparison process between the acquired first reference value, the second reference value, the third reference value, the first comparison value, the second comparison value, and the third comparison value to determine the possibility that the user has a mental illness.

[0115] A 34th aspect of the determination device is the 33rd aspect of the determination device, wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of the third reference value and the magnitude of the third comparison value.

[0116] The judgment device of the 35th aspect is the judgment device of the 33rd or 34th aspect, wherein the judgment unit judges the possibility that the user has a mental illness by comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value.

[0117] A 36th aspect of the determination device is the determination device of the 32nd aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency; the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency is applied; the second comparison value is a heart rate variability index of the user to which the sound stimulation of the first frequency is applied; and the acquisition unit acquires, in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a fourth reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is a heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied; and the determination unit performs a comparison process between the acquired first reference value, the second reference value, the fourth reference value, the first comparison value, the second comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

[0118] A 37th aspect of the determination device is the 36th aspect of the determination device, wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of the fourth reference value and the magnitude of the fourth comparison value.

[0119] The determination device of the 38th aspect is the determination device of the 36th or 37th aspect, wherein the determination unit determines the possibility that the user has a mental illness by comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value.

[0120] A 39th aspect of the determination device is the determination device of the 32nd aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency is applied, and the second comparison value is a heart rate variability index of the user to which the sound stimulation of the first frequency is applied, and the acquisition unit acquires, in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is the heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, a third comparison value which is the heart rate variability index of the user to which the sound stimulation of the second frequency is applied, a fourth reference value which is the heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is the heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, The judgment unit performs a comparison process between the acquired first reference value, second reference value, third reference value, fourth reference value, first comparison value, second comparison value, third comparison value, and fourth comparison value to judge the possibility that the user has a mental illness.

[0121] The judgment device of the 40th aspect is the judgment device of the 39th aspect, wherein the judgment unit compares the magnitude of the third reference value and the third comparison value, and compares the magnitude of the fourth reference value and the fourth comparison value, thereby judging the possibility that the user has a mental illness.

[0122] The judgment device of the 41st aspect is the judgment device of the 39th or 40th aspect, wherein the judgment unit compares the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value, and compares the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value, thereby judging the possibility that the user has a mental illness.

[0123] The determination device of the 42nd aspect is the determination device of the 32nd aspect, wherein the sound stimulation applied in the second sound stimulation environment includes a sound stimulation of a first frequency and a sound stimulation of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, and the second comparison value is a heart rate variability index of the user to which the sound stimulation of the second frequency is applied.

[0124] A 43rd aspect of the determination device is the determination device of any one of the 25th to 42nd aspects, wherein the mental disorder is a state in which symptoms of depression, mania, anxiety, or hallucinations / delusions are present.

[0125] A 44th aspect of the determination device is the determination device of any one of the 25th to 42nd aspects, wherein the mental disorder is a mood disorder, an anxiety disorder, or schizophrenia.

[0126] A 45th aspect of the determination device is the determination device of any one of the 25th to 42nd aspects, wherein the mental illness is a mood disorder or schizophrenia.

[0127] A 46th aspect of the determination device is the 45th aspect of the determination device, wherein the mood disorder is depression or bipolar disorder.

[0128] A 47th aspect of the determination device is the 46th aspect of the determination device, wherein the bipolar disorder is a depressive episode.

[0129] A determination system of a 48th aspect includes: a determination device of any one of the 25th to 47th aspects; an analysis device that analyzes a heart rate variability index of the healthy subject or the user; and a stimulation device that applies sound stimulation to the healthy subject or the user.

[0130] Any of the various embodiments or modifications described above can be combined appropriately to achieve the effects of each. In addition, combinations of embodiments, combinations of examples, or combinations of embodiments and examples are possible, and combinations of features from different embodiments or examples are also possible.

[0131] Although the present disclosure has been fully described in connection with the preferred embodiments with reference to the accompanying drawings, various changes and modifications will be apparent to those skilled in the art, and such changes and modifications are to be understood as being included within the scope of the present disclosure as defined by the appended claims unless they depart therefrom.

[0132] REFERENCE SIGNS LIST 1 Psychiatric illness assessment system 10 Stimulation device 20 Analysis device 30 Assessment device 31 Acquisition unit 32 Assessment unit 301 CPU 302 Storage device

Claims

1. Obtain a first reference value which is a heart rate variability index of a healthy subject in a first sound stimulation environment, a second reference value which is a heart rate variability index of the healthy subject in a second sound stimulation environment different from the first sound stimulation environment, a first comparison value which is a heart rate variability index of the user in the first sound stimulation environment, and a second comparison value which is a heart rate variability index of the user in the second sound stimulation environment; A method for determining a mental illness, which performs a comparison process between the first reference value, the second reference value, the first comparison value, and the second comparison value to determine the possibility that the user has a mental illness.

2. 2. The determination method of claim 1, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is a value calculated from at least one of a plurality of indices including a high-frequency component of a heart rate variability index and a low-frequency component of a heart rate variability index.

3. 3. The determination method according to claim 2, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is a ratio of the low frequency component to the high frequency component, LF / HF.

4. The method of claim 1 , wherein the heart rate variability index is analyzed from a pulse wave or an electrocardiogram.

5. The method of claim 1 , further comprising: comparing the magnitudes of the first reference value and the first comparison value to determine whether the user has a mental illness.

6. The method of claim 1 , further comprising: comparing the magnitudes of the second reference value and the second comparison value to determine whether the user has a mental illness.

7. The method of claim 1, wherein the possibility that the user has a mental illness is determined by comparing the rate of change of the second reference value relative to the first reference value with the rate of change of the second comparison value relative to the first comparison value.

8. In the first sound stimulus environment, no sound stimulus is provided or a sound stimulus is provided; The method of claim 1 , wherein a sound stimulus is applied in the second sound stimulus environment.

9. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the first frequency is applied, the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the first frequency is applied, In addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, and a third comparison value which is a heart rate variability index of the user to which the sound stimulation of the second frequency is applied are obtained, The method of claim 8, wherein a comparison process is performed between the first reference value, the second reference value, the third reference value, the first comparison value, the second comparison value, and the third comparison value to determine the possibility that the user has a mental illness.

10. The method of claim 9 , further comprising: comparing the magnitudes of the third reference value and the third comparison value to determine the possibility that the user has a mental illness.

11. The method of claim 9, wherein the possibility that the user has a mental illness is determined by comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value.

12. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the first frequency is applied, the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the first frequency is applied, In addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a fourth reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is a heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied are obtained; The method of claim 8, wherein a comparison process is performed between the first reference value, the second reference value, the fourth reference value, the first comparison value, the second comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

13. The method of claim 12 , further comprising: comparing the magnitudes of the fourth reference value and the fourth comparison value to determine the possibility that the user has a mental illness.

14. The method of claim 12, wherein the possibility that the user has a mental illness is determined by comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value.

15. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the first frequency is applied, the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the first frequency is applied, In addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is the heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, a third comparison value which is the heart rate variability index of the user to which the sound stimulation of the second frequency is applied, a fourth reference value which is the heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is the heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, are obtained; 9. The method of claim 8, wherein a comparison process is performed between the first reference value, the second reference value, the third reference value, the fourth reference value, the first comparison value, the second comparison value, the third comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

16. The method of claim 15, wherein the magnitude of the third reference value and the third comparison value are compared, and the magnitude of the fourth reference value and the fourth comparison value are compared to determine whether the user is likely to have a mental illness.

17. 16. The method of claim 15, further comprising: comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value; and comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value, thereby determining the possibility that the user has a mental illness.

18. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the second frequency is applied, The determination method according to claim 8 , wherein the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the second frequency is applied.

19. The method for determining a mental disorder according to claim 9, wherein the mental disorder is a state in which symptoms of depression, mania, anxiety, or hallucinations / delusions are present.

20. The method of claim 9, wherein the psychiatric disorder is a mood disorder, an anxiety disorder, or schizophrenia.

21. The method of claim 9, wherein the psychiatric disorder is a mood disorder or schizophrenia.

22. The method of claim 21, wherein the mood disorder is depression or bipolar disorder.

23. The method of claim 22, wherein the bipolar disorder is a depressive episode.

24. A program for causing a computer to execute the determination method of claim 9.

25. an acquisition unit that acquires a first reference value that is a heart rate variability index of a healthy subject in a first sound stimulation environment, a second reference value that is a heart rate variability index of the healthy subject in a second sound stimulation environment, a first comparison value that is a heart rate variability index of a user in the first sound stimulation environment, and a second comparison value that is a heart rate variability index of the user in the second sound stimulation environment; a determination unit that determines the possibility that the user has a mental illness based on the acquired first reference value, the second reference value, the first comparison value, and the second comparison value; A mental illness assessment device comprising:

26. 26. The determination device of claim 25, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is a value calculated from at least one of a plurality of indices including a high-frequency component of a heart rate variability index and a low-frequency component of a heart rate variability index.

27. 27. The determination device according to claim 26, wherein each of the first reference value, the second reference value, the first comparison value, and the second comparison value is LF / HF, which is a ratio of the low frequency component to the high frequency component.

28. The determination device according to claim 25 , wherein the acquisition unit acquires the heart rate variability index analyzed from a pulse wave or an electrocardiogram.

29. The determination device according to claim 25 , wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of the first reference value and the magnitude of the first comparison value.

30. The determination device according to claim 25 , wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of a second reference value and the magnitude of the second comparison value.

31. 26. The determination device of claim 25, wherein the determination unit determines the possibility that the user has a mental illness by comparing the rate of change of the second reference value relative to the first reference value with the rate of change of the second comparison value relative to the first comparison value.

32. In the first sound stimulus environment, no sound stimulus is provided or a sound stimulus is provided; The determination device according to claim 25 , wherein a sound stimulus is applied in the second sound stimulus environment.

33. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the first frequency is applied, the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the first frequency is applied, the acquisition unit acquires, in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, and a third comparison value which is a heart rate variability index of the user to which the sound stimulation of the second frequency is applied; 33. The determination device of claim 32, wherein the determination unit performs a comparison process between the acquired first reference value, the second reference value, the third reference value, the first comparison value, the second comparison value, and the third comparison value to determine the possibility that the user has a mental illness.

34. The determination device according to claim 33 , wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitudes of the third reference value and the third comparison value.

35. The determination device of claim 33, wherein the determination unit determines the possibility that the user has a mental illness by comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value.

36. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the first frequency is applied, the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the first frequency is applied, The acquisition unit acquires, in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a fourth reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is a heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, The determination device of claim 32, wherein the determination unit performs a comparison process between the acquired first reference value, the second reference value, the fourth reference value, the first comparison value, the second comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

37. The determination device according to claim 36 , wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of the fourth reference value and the magnitude of the fourth comparison value.

38. The determination device of claim 36, wherein the determination unit determines the possibility that the user has a mental illness by comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value.

39. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the first frequency is applied, the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the first frequency is applied, The acquisition unit acquires, in addition to the first reference value, the second reference value, the first comparison value, and the second comparison value, a third reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the second frequency is applied, a third comparison value which is a heart rate variability index of the user to which the sound stimulation of the second frequency is applied, a fourth reference value which is a heart rate variability index of the healthy subject to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, and a fourth comparison value which is a heart rate variability index of the user to which the sound stimulation of the first frequency and the sound stimulation of the second frequency are simultaneously applied, 33. The determination device of claim 32, wherein the determination unit performs a comparison process between the acquired first reference value, the second reference value, the third reference value, the fourth reference value, the first comparison value, the second comparison value, the third comparison value, and the fourth comparison value to determine the possibility that the user has a mental illness.

40. 40. The determination device of claim 39, wherein the determination unit determines the possibility that the user has a mental illness by comparing the magnitude of the third reference value and the third comparison value and comparing the magnitude of the fourth reference value and the fourth comparison value.

41. 40. The determination device of claim 39, wherein the determination unit determines the possibility that the user has a mental illness by comparing the rate of change of the third reference value relative to the first reference value with the rate of change of the third comparison value relative to the first comparison value, and by comparing the rate of change of the fourth reference value relative to the first reference value with the rate of change of the fourth comparison value relative to the first comparison value.

42. The sound stimulus applied in the second sound stimulus environment includes a sound stimulus of a first frequency and a sound stimulus of a second frequency higher than the first frequency, the second reference value is a heart rate variability index of the healthy subject to which the sound stimulus of the second frequency is applied, The determination device of claim 32, wherein the second comparison value is a heart rate variability index of the user to whom the sound stimulus of the second frequency is applied.

43. The determination device according to claim 33, wherein the psychiatric disorder is a state in which symptoms of depression, mania, anxiety, or hallucinations / delusions are present.

44. The determination device of claim 33, wherein the psychiatric disorder is a mood disorder, an anxiety disorder, or schizophrenia.

45. The determination device of claim 33, wherein the psychiatric disorder is a mood disorder or schizophrenia.

46. The determination device of claim 45, wherein the mood disorder is depression or bipolar disorder.

47. The determination device of claim 46, wherein the bipolar disorder is a depressive episode.

48. The determination device of claim 33; an analysis device that analyzes the heart rate variability index of the healthy subject or the user; a stimulation device that provides sound stimulation to the healthy person or the user; A mental illness assessment system comprising: