Infusion oxygenation device and infusion oxygenation system

Abstract

Provided are an infusion oxygenation device and an infusion oxygenation system with which it is possible to safely, simply, and quickly supply oxygen to an infusion. This infusion oxygenation device comprises: a catheter connection part which connects a catheter for supplying an oxygen-containing gas to an infusion inside an infusion container; a gas supply part which supplies the oxygen-containing gas to the catheter connection part; and a container pressure detection part which detects the internal pressure of the infusion container, wherein the gas supply part controls the supply of the oxygen-containing gas on the basis of the internal pressure of the infusion container detected by the container pressure detection part.

Description

Infusion oxygenation device and infusion oxygenation system

[0001] The present disclosure relates to an infusion oxygenation device and an infusion oxygenation system.

[0002] Japanese Patent Laid-Open Publication No. 2006 / 263018 (Patent Document 1) describes an infusion line monitoring system. This infusion line monitoring system detects a power supply frequency signal induced by the capacitance formed between the power line and the living body using electrodes attached to the infusion line. The infusion line is composed of a tube, catheter, etc., through which medicinal solution or blood flows. One end of the infusion line is equipped with a needle or thin tube, which can be inserted into a desired location in the living body to allow infusion of medicinal solution or other fluid into the living body. The other end of the infusion line is connected to a medicinal solution bottle. Electrodes are provided along the infusion line.

[0003] JP 2019-500195 A (Patent Document 2) describes a system for infusing gas-containing medical liquids, relating to a system and method for delivering a liquid containing a dissolved medical gas directly via the arterial system, and a system and method for mitigating the harm of inadvertent injection of air during a medical procedure, particularly when flushing a line with fluid prior to insertion into the body. The system includes an automatic degasser and medical gas regasifier including a medical gas cylinder with a regulator, a vacuum pump, a three-way valve with a solenoid, a controller connection to the solenoid, a thermally insulating container, a collapsible fluid tank with a gas / physiological layer, a three-way valve, an in-line fluid sensor, e.g., one portion connected to a line adjacent to the three-way valve and a second portion connected to a fluid path to a catheter adjacent to the catheter distal to the fluid tank, a controller including a power supply, an ultrasonic processor connected to the controller, a heater / cooler including a temperature sensor and a connection to a computer via a connection from the solenoid to the controller, the three-way valve with a solenoid, and a fluid path to the catheter that may include a connector to the catheter system. In this system, for example, oxygen is dissolved in saline solution, and the saline solution is used as an oxygen carrier to provide oxygen to a patient, for example, by intravenous infusion of the saline solution.

[0004] Japanese Patent Application Laid-Open No. 2007-289695 (Patent Document 3) describes an oxygenator having a gas exchange membrane that separates the blood side from the gas side.

[0005] JP 2006 / 263018 A, JP 2019-500195 A, JP 2007-289695 A

[0006] In living organisms, a decrease in arterial oxygen saturation (also known as SpO2 (saturation of percutaneous oxygen), also known as blood oxygen saturation) leads to a decrease in the amount of oxygen supplied to the periphery. This leads to a hypoxic state in peripheral tissues. In such a state of pulmonary dysfunction, treatments include transpulmonary oxygen supply, such as adjusting the oxygen concentration of respiratory gas, positive pressure oxygen therapy, and the use of an artificial ventilator, as well as oxygen supply using an extracorporeal circulation system using an artificial lung and a blood pump (see, for example, Patent Document 3). However, transpulmonary oxygen supply may not be sufficiently effective if the gas exchange capacity of the lungs is impaired. Furthermore, the need for tracheal cannula placement poses the problem of unavoidable invasiveness and laboriousness. Using an extracorporeal circulation system requires the cooperation of multiple people, including a doctor, technician, and nurse, and is therefore laborious. Furthermore, extracorporeal circulation systems may not be quickly ready for use, and even after installation, it may take a long time for them to be used. This may hinder prompt treatment of the patient.

[0007] Supplying oxygen to a patient via infusion (see, for example, Patent Document 2) has the potential to be minimally invasive. Furthermore, if infusion solutions containing dissolved oxygen could be prepared, oxygen could be rapidly supplied to patients. However, there are currently no methods for safely, easily, or quickly dissolving oxygen in infusion solutions. Therefore, there is a need for a device that can safely, easily, or quickly supply oxygen to infusion solutions.

[0008] The present disclosure has been made in consideration of the above circumstances, and its purpose is to provide an infusion oxygenation device and an infusion oxygenation system that can safely, easily, and quickly supply oxygen to infusions.

[0009] In order to achieve the above object, the infusion oxygenation device according to the present disclosure comprises: a catheter connection unit for connecting a catheter that supplies oxygen-containing gas to the infusion in an infusion container; a gas supply unit that supplies the oxygen-containing gas to the catheter connection unit; and a container pressure detection unit that detects the internal pressure of the infusion container, wherein the gas supply unit controls the supply of the oxygen-containing gas based on the internal pressure detected by the container pressure detection unit.

[0010] In the infusion oxygenation device according to the present disclosure, the catheter connection section may further include an air supply section that supplies the oxygen-containing gas into the infusion container, and an exhaust section that exhausts the gas from the infusion container.

[0011] The infusion oxygenation device according to the present disclosure may further include an oxygen concentration detection unit that detects the oxygen concentration of the infusion, and the gas supply unit may control the supply of the oxygen-containing gas based on the oxygen concentration detected by the oxygen concentration detection unit.

[0012] The infusion oxygenation device according to the present disclosure may further include a pressure regulating unit that adjusts the internal pressure of the infusion container, and the pressure regulating unit may adjust the internal pressure based on the oxygen concentration detected by the oxygen concentration detecting unit.

[0013] The infusion oxygenation device according to the present disclosure may further include a bioinformation acquisition unit that acquires bioinformation of a patient, and the gas supply unit may control the supply of the oxygen-containing gas based on the bioinformation acquired by the bioinformation acquisition unit.

[0014] The infusion oxygenation device according to the present disclosure may further include, as the biological information, blood oxygen saturation, inspired oxygen concentration, blood pressure, heart rate, respiratory rate, tissue oxygen saturation, arterial blood oxygen partial pressure, mixed venous blood oxygen saturation, urinary oxygen partial pressure, intravesical pressure, cerebral / tissue oxygen saturation, urine volume, body temperature, or cardiac output.

[0015] The infusion oxygenation device according to the present disclosure may further include a remaining amount detection unit that detects the remaining amount of infusion in the infusion container, and the gas supply unit may control the supply of the oxygen-containing gas based on the remaining amount of infusion acquired by the remaining amount detection unit.

[0016] The infusion oxygenation device according to the present disclosure may further include a temperature detection unit that detects the temperature of the infusion, and the gas supply unit may control the supply of the oxygen-containing gas based on the temperature detected by the temperature detection unit.

[0017] The infusion oxygenation device according to the present disclosure further includes an oxygen concentration detection unit that detects the oxygen concentration of the infusion, a temperature detection unit that detects the temperature of the infusion, and a temperature control signal transmission unit that transmits a temperature control signal to adjust the temperature of the infusion, and the temperature control signal transmission unit may transmit the temperature control signal based on the temperature detected by the temperature detection unit or the oxygen concentration detected by the oxygen concentration detection unit.

[0018] The infusion oxygenation device according to the present disclosure further includes an oxygen concentration detection unit that detects the oxygen concentration of the infusion, and a pressure adjustment signal transmission unit that transmits a pressure adjustment signal to adjust the internal pressure of the infusion container, and the pressure adjustment signal transmission unit may transmit the pressure adjustment signal based on the internal pressure detected by the container pressure detection unit or the oxygen concentration detected by the oxygen concentration detection unit.

[0019] The infusion oxygenation device according to the present disclosure may further include: a first connection part connected to a supply source of a first gas containing oxygen gas; and a second connection part connected to a supply source of a second gas different from the first gas, wherein the second gas contains nitrogen, argon, nitric oxide, laughing gas, or carbon dioxide, and the gas supply part may prepare the oxygen-containing gas by mixing the first gas and the second gas.

[0020] To achieve the above object, the infusion oxygenation system according to the present disclosure includes a catheter that supplies an oxygen-containing gas to the infusion in an infusion container, a gas supply unit that supplies the oxygen-containing gas to the catheter, and a container pressure detection unit that detects the internal pressure of the infusion container, and the gas supply unit controls the supply of the oxygen-containing gas based on the internal pressure detected by the container pressure detection unit.

[0021] The infusion oxygenation system according to the present disclosure may further comprise: the catheter having a supply lumen for supplying the oxygen-containing gas into the infusion container; and an exhaust lumen for exhausting the gas from the infusion container.

[0022] It is possible to provide an infusion oxygenation device and an infusion oxygenation system that can safely, easily, and quickly supply oxygen to an infusion.

[0023] 1 is a diagram illustrating the configuration of an infusion oxygenation device according to a first embodiment and an infusion oxygenation system including the same. FIG. 1 is a functional block diagram of an infusion oxygenation device according to the first embodiment. FIG. 2 is an example of a usage state of an infusion oxygenation device and an infusion oxygenation system including the same. FIG. 3 is a diagram illustrating the structure of a catheter. FIG. 4 is a cross-sectional view taken along the arrow V-V in FIG. 4. FIG. 5 is a diagram illustrating an example of a display on a display unit. FIG. 6 is a diagram illustrating an example of a display on a display unit. FIG. 7 is a graph showing the results of an animal experiment. FIG. 8 is a diagram illustrating the configuration of an infusion oxygenation device according to a second embodiment and an infusion oxygenation system including the same. FIG. 9 is a diagram illustrating the configuration of an infusion oxygenation device according to a third embodiment and an infusion oxygenation system including the same. FIG. 10 is a diagram illustrating the configuration of an infusion oxygenation device according to a first modification. FIG. 11 is a functional block diagram of an infusion oxygenation device according to modifications 2 and 3. FIG. 12 is a diagram illustrating the configuration of an infusion oxygenation device according to another embodiment and an infusion oxygenation system including the same. FIG. 13 is a diagram illustrating the configuration of an infusion oxygenation device according to another embodiment and an infusion oxygenation system including the same.

[0024] An infusion oxygenation device and an infusion oxygenation system according to an embodiment of the present disclosure will be described with reference to the drawings.

[0025] (First embodiment) (Overview) Fig. 1 shows an infusion oxygenation system 200 including an infusion oxygenation device 100 according to this embodiment. Fig. 2 shows a functional block diagram of the infusion oxygenation device 100. Fig. 3 shows an example of a usage situation of the infusion oxygenation device 100 and the infusion oxygenation system 200.

[0026] As shown in FIG. 1, the infusion oxygenation system 200 includes an infusion oxygenation device 100 and a catheter 6 connected to the infusion oxygenation device 100 for supplying oxygen-containing gas to the infusion in an infusion container 7.

[0027] The infusion oxygenation device 100 includes a catheter connection part 1 for connecting a catheter 6 that supplies oxygen-containing gas to the infusion in an infusion container 7, a gas supply part 21 that supplies oxygen-containing gas to the catheter connection part 1, and a container pressure detection part 31 that detects the internal pressure of the infusion container 7 (hereinafter simply referred to as internal pressure).

[0028] The gas supply unit 21 controls the supply of oxygen-containing gas based on the internal pressure of the infusion container 7 detected by the container pressure detection unit 31.

[0029] The infusion oxygenation device 100 and the infusion oxygenation system 200 using the same can safely, easily, and quickly supply oxygen to the infusion.

[0030] 1, an infusion oxygenation system 200 includes an infusion oxygenation device 100 and a catheter 6. The catheter 6 is used by being inserted into an infusion container 7 such as an intravenous drip bag.

[0031] First, the overall configuration of the infusion oxygenation system 200 and the infusion oxygenation device 100 will be described.

[0032] The infusion oxygenation device 100 includes a housing 10, a catheter connection part 1 to which a catheter 6 is connected, a gas supply part 21 to supply an oxygen-containing gas to the catheter connection part 1, and a connection part 8 to be connected to a supply source of the oxygen-containing gas (for example, an oxygen cylinder B). The infusion oxygenation device 100 supplies the oxygen-containing gas from the oxygen cylinder B to the catheter 6 via the catheter connection part 1. The catheter 6 releases and supplies the oxygen-containing gas into the infusion in the infusion container 7, dissolving oxygen in the infusion.

[0033] Hereinafter, dissolving oxygen in an infusion to increase the oxygen concentration of the infusion may be simply referred to as oxygenation, etc. For example, when describing oxygenating an infusion, it means supplying oxygen to the infusion to dissolve oxygen in the infusion and increase the oxygen concentration of the infusion.

[0034] The infusion oxygenator 100 may be used by hanging it from an infusion stand, for example. The infusion oxygenator 100 may have a locking portion (not shown) on the housing 10 that can be locked to an infusion stand (see FIG. 3). Alternatively, the infusion oxygenator 100 may have a locking portion that can be connected and fixed to a patient's bed or other medical equipment, or may have an independent stand.

[0035] The infusion oxygenation device 100 is equipped with a container pressure detection unit 31 that detects the internal pressure of the infusion container 7 (hereinafter simply referred to as internal pressure) to ensure the safety of oxygen supply to the infusion and the safety of the infusion containing dissolved oxygen when administered to a patient. In the infusion oxygenation device 100, the supply of oxygen-containing gas from the gas supply unit 21 is controlled based on the internal pressure detected by the container pressure detection unit 31. This makes it possible to prevent, for example, the infusion container 7 from bursting and to avoid problems such as the concentration of oxygen dissolved in the infusion becoming too low or too high.

[0036] In order to grasp the state inside the infusion container 7 and manage and control the infusion, the infusion oxygenation device 100 may include, in addition to a container pressure detection unit 31, an oxygen concentration detection unit 32 that detects the oxygen concentration of the infusion, a temperature detection unit 33 that detects the temperature of the infusion, and a remaining amount detection unit 34 that detects the remaining amount of infusion in the infusion container 7, as shown in FIG. 2 . The infusion oxygenation device 100 may also include a biological information acquisition unit 35 that acquires biological information of the patient. In the following, the present embodiment will be described by taking as an example a case where the infusion oxygenation device 100 includes the oxygen concentration detection unit 32, the temperature detection unit 33, the remaining amount detection unit 34, and the biological information acquisition unit 35.

[0037] The infusion oxygenation device 100 may include, in addition to the gas supply unit 21, a pressure adjustment unit 25 that adjusts the internal pressure of the infusion container 7. In the present embodiment, the infusion oxygenation device 100 including the pressure adjustment unit 25 will be described below.

[0038] The infusion oxygenation device 100 may include a notification unit 90 that notifies a user, such as a doctor or a nurse, of the operating state of the infusion oxygenation device 100 and the state of the infusion container 7 and the infusion. In the following, the present embodiment will be described by taking as an example a case where the infusion oxygenation device 100 includes the notification unit 90.

[0039] The infusion oxygenation device 100 may include an input unit 95 that accepts input of operation commands from a user. In the following, the present embodiment will be described by taking as an example a case where the infusion oxygenation device 100 includes the input unit 95.

[0040] The infusion oxygenation device 100 may include a communication unit W that exchanges information and operational commands with external medical devices and sensors. In the following, the present embodiment will be described by taking as an example a case where the infusion oxygenation device 100 includes the communication unit W.

[0041] In this embodiment, the operation of each part of the infusion oxygenation device 100 may be controlled based on an operation command from the control unit C. In the following, this embodiment will be described by taking as an example a case where the infusion oxygenation device 100 is controlled based on an operation command from the control unit C.

[0042] Each component of the infusion oxygenation system 200 and the infusion oxygenation device 100 will be described below.

[0043] 2 is a functional unit that serves as the central control mechanism of the infusion oxygenation device 100 and controls the operation of the infusion oxygenation device 100. The control unit C receives information related to the operating status and detection status from each unit of the infusion oxygenation device 100, external sensors, and external devices, and also sends operation commands to each unit of the infusion oxygenation device 100, external sensors, and external devices to control their operation. Specific control performed by the control unit C will be described later.

[0044] The control unit C may be realized in hardware or software by a CPU and a program (software) that causes the CPU to control the infusion oxygenation device 100. The control unit C may be realized by a computer such as a personal computer, microcomputer, or PLC, and control software stored in its storage device. In this embodiment, the control unit C is realized in software by a CPU (not shown) built into the infusion oxygenation device 100 executing a program stored in a storage unit M built into the infusion oxygenation device 100. The control unit C and the storage unit M can be communicatively connected to each component of the infusion oxygenation device 100 via a communication path N formed by a port, a bus, a wired or wireless network (including the Internet), or the like. The storage unit M can be a storage device or storage medium such as a flash memory, a hard disk, an SSD, or an optical disk such as a CD-ROM.

[0045] The communication unit W can communicate with external medical devices and sensors (hereinafter, sometimes referred to as external devices) by wireless communication via the antenna 19, for example, and mediate the exchange of information and operational commands between the infusion oxygenation device 100 and the external devices. Note that the communication unit W is not limited to wireless communication, and may also perform analog communication via a BNC, pin jack, dedicated connector, etc., digital communication via RS-232C, USB, etc., or communication via a wired communication line, such as a combination thereof. Although individual examples will be omitted, any wireless communication in this embodiment can be replaced with wired communication.

[0046] In this embodiment, each unit of the infusion oxygenation device 100 can communicate with an external device as needed via the communication unit W. In the following description, communication between each unit of the infusion oxygenation device 100 and an external device is mediated by the communication unit W, and individual descriptions may be omitted.

[0047] 1, the catheter connector 1 is a connection mechanism for connecting a supply tube 16 connected to a catheter 6 to an infusion oxygenation device 100. The catheter connector 1 is, for example, a liquid-tight joint such as a Luer connector. The catheter connector 1 may be fixed to a housing 10, for example.

[0048] The gas supply unit 21 is a supply control mechanism that supplies oxygen-containing gas to the catheter 6 and controls the supply. The gas supply unit 21 adjusts the amount of oxygen-containing gas supplied to the supply tube 16 connected to the catheter connection unit 1. The gas supply unit 21 may be an aperture adjustment valve that can adjust the amount of oxygen-containing gas supplied by adjusting the aperture, and a needle valve or a diaphragm valve may be used, for example. In this case, the gas supply unit 21 may be an automatic valve equipped with an actuator. The gas supply unit 21 receives oxygen-containing gas from an oxygen-containing gas supply source and supplies the oxygen-containing gas to the supply tube 16. The gas supply unit 21 is housed, for example, in the housing 10.

[0049] The pressure adjustment unit 25 is a pressure adjustment mechanism that adjusts the internal pressure of the infusion container 7. In this embodiment, as an example, the pressure adjustment unit 25 adjusts the pressure of the oxygen-containing gas supplied from the catheter 6 to the infusion container 7 by supplying pressure-adjusted oxygen-containing gas to the gas supply unit 21, thereby adjusting the internal pressure of the infusion container 7. The pressure adjustment unit 25 may be a pressure adjustment valve that can adjust or control the downstream pressure, and may be, for example, a pressure increase valve or a pressure reduction valve. In this embodiment, as an example, a pressure reduction valve such as a needle valve or a diaphragm valve may be used. The pressure adjustment unit 25 is housed, for example, in the housing 10.

[0050] The connection part 8 is an interface such as a joint for connecting a supply source of oxygen-containing gas. For example, an oxygen cylinder B as a supply source of oxygen-containing gas is connected to the connection part 8. The pressure adjustment part 25 and the gas supply part 21 described above are connected downstream of the connection part 8, and the oxygen-containing gas is supplied to the catheter connection part 1 via the gas supply part 21. The connection part 8 is housed, for example, in a housing 10. A housing part 18 for housing the oxygen cylinder B may be provided in the housing 10.

[0051] The infusion container 7 is a container for storing infusion fluid, such as an intravenous drip bag. The infusion container 7 is, for example, a liquid-tight bag or cylindrical container that prevents leakage of the infusion fluid from the inside. The infusion container 7 has a catheter insertion section 71 into which a catheter 6 is inserted into a partition wall of the container body, and a discharge port 72 through which the infusion fluid is discharged. The discharge port 72 is connected to an infusion tube 75 that supplies the infusion fluid to a patient. In this embodiment, the catheter insertion section 71 and the discharge port 72 are one of multiple (e.g., three or four) insertion ports provided on a rubber stopper section 70 provided at the lower end of the infusion container 7. As shown in FIG. 3 , an intravenous drip tube 76 is connected to the infusion tube 75, and an infusion pump 77 and a clamp 78 are also provided.

[0052] 1 and 4, the catheter 6 has a gas tube connection part 61 to which the supply tube 16 (see FIG. 1) is connected, a supply pipe 62 to which oxygen-containing gas is supplied from the gas tube connection part 61, a gas dispersion mechanism 63 provided at the outlet of the supply pipe 62 and exhausting the oxygen-containing gas to the infusion container 7, an exhaust pipe 65 for exhausting gas (hereinafter referred to as exhaust gas) from the infusion container 7, and an exhaust valve 66 for releasing the exhaust gas from the exhaust pipe 65 to the outside of the infusion container 7. The catheter 6 may be formed, for example, in the shape of a straight rod.

[0053] 1, the gas tube connection part 61 is a joint mechanism for connecting the supply tube 16. It is sufficient that the structure is airtight and does not come off unexpectedly.

[0054] 1 and 4, the supply pipe 62 is a pipe member forming a supply lumen for supplying oxygen-containing gas into the infusion container 7. The supply pipe 62 is connected in communication with the gas tube connecting part 61, and supplies the oxygen-containing gas supplied from the gas tube connecting part 61 into the infusion in the infusion container 7 (see FIG. 1) via a gas dispersion mechanism 63 provided at the outlet on the downstream side in the flow of the oxygen-containing gas.

[0055] The gas dispersion mechanism 63 may be formed of, for example, a mesh-like member (e.g., a mesh or a sponge), and can supply the oxygen-containing gas supplied from the supply pipe 62 as fine bubbles into the infusion liquid. This improves the efficiency of supplying oxygen to the infusion liquid, i.e., dissolving oxygen into the infusion liquid. The supply pipe 62 may be provided with a check valve (not shown) to prevent backflow of the oxygen-containing gas and the infusion liquid.

[0056] The exhaust pipe 65 is a tubular member that forms an exhaust lumen for exhausting exhaust gas from inside the infusion container 7. One end (exhaust gas inlet) of the exhaust pipe 65 is open inside the infusion container 7 (see FIG. 1), and the exhaust gas is taken in from inside the infusion container 7 and released to the outside of the infusion container 7 via an exhaust valve 66 connected to the other end. If necessary, a filter (not shown), such as a mesh or porous material, may be provided at the inlet of the exhaust pipe 65 to prevent the intrusion of the infusion liquid.

[0057] The exhaust valve 66 can be a check valve that prevents backflow of external air into the infusion container 7 (see Figure 1). Preventing backflow of external air into the infusion container 7 can prevent infectious diseases. The exhaust valve 66 can also be a one-way valve such as a duckbill valve, or a valve with a flow rate or pressure adjustment mechanism, such as a needle valve or diaphragm valve, that can adjust the internal pressure of the infusion container 7. It can also be a breathable filter that is impermeable to liquids. This can improve the efficiency of oxygen dissolution into the infusion solution and adjust the oxygen concentration in the infusion solution. A filter 66a may be provided at the outlet of the exhaust valve 66 to prevent the entry of bacteria and viruses, preventing external contamination of the infusion container 7. Specifically, the pore size of the filter 66a can be selected depending on the type of contamination to be prevented; filters with a pore size of 0.8 to 0.1 μm are often used. For example, filters with a pore size of 0.45 μm are often used to prevent bacterial contamination.

[0058] 4 and 5 illustrate an example in which the catheter 6 has a double-tube structure. In the example shown in FIGS. 4 and 5, the supply tube 62 is an outer tube, and the exhaust tube 65 is an inner tube. In this case, the supply lumen is the internal space of the supply tube 62 and the external space of the exhaust tube 65. In this case, the gas dispersion mechanism 63 may be disposed at the outlet end of the supply tube 62, along the outer peripheral surface of the exhaust tube 65.

[0059] 1 , one end of the exhaust pipe 65, i.e., the exhaust gas inlet of the exhaust pipe 65, is arranged above the gas dispersion mechanism 63 when the catheter 6 is inserted into the infusion container 7. When the catheter 6 is inserted into the infusion container 7, the exhaust gas inlet of the exhaust pipe 65 is arranged so as to be located above the liquid level H of the infusion. The gas dispersion mechanism 63 is arranged within the infusion, i.e., below the liquid level H of the infusion. When the catheter 6 is inserted into the infusion container 7, the gas tube connection part 61 and the exhaust valve 66 are arranged outside the infusion container 7.

[0060] The tip of the catheter 6 (the end inserted into the infusion container 7) is preferably made of a soft material or has a flexible structure to prevent damage to the infusion container 7 (for example, when the infusion container 7 is an intravenous bag, the bag may be torn). For example, the tip of the exhaust pipe 65 may be made of a rubber-like material, or the tip of the exhaust pipe 65 may have a bellows structure to impart flexibility.

[0061] Alternatively, the distal end of the catheter 6 may be provided with a split structure or mechanism (e.g., a structure that opens in a cross shape or a structure or mechanism that opens like a pantograph, not shown) at the distal end. These structures or mechanisms can fix the position of the catheter 6 in the infusion container 7.

[0062] As shown in FIG. 2, the container pressure detection unit 31 may be a sensor that detects the internal pressure of the infusion container 7 (see FIG. 1), a circuit that detects the internal pressure of the infusion container 7 based on a signal output from the sensor, or a functional unit realized by executing a program by a CPU or the like. Detecting the internal pressure of the infusion container 7 enables control that ensures safety by preventing the infusion container 7 from bursting or administering infusion fluid from the infusion container 7 to a patient at an excessively high rate. Furthermore, detecting the internal pressure of the infusion container 7 makes it possible to adjust the oxygen concentration of the infusion fluid. Furthermore, these actions or effects allow the user to easily and quickly supply oxygen to the infusion fluid.

[0063] In this embodiment, the container pressure detection unit 31 may include a sensor for detecting pressure. The container pressure detection unit 31 can indirectly detect the internal pressure of the infusion container 7, for example, by detecting the pressure of the oxygen-containing gas in the supply tube 16 via a tube 13a connected to a pressure detection port 13 provided in the catheter connection unit 1. Fig. 1 shows a case in which the tube 13a is connected to a pressure sensor connection unit 13b provided in the housing 10. That is, the container pressure detection unit 31 is connected to the supply tube 16 via the pressure sensor connection unit 13b.

[0064] The oxygen concentration detection unit 32 shown in FIG. 2 may be a sensor that detects the oxygen concentration of the infusion (e.g., oxygen concentration (% O, g / L), oxygen partial pressure (mmHg, Torr, mbar), oxygen saturation (%), etc.), a circuit that detects the oxygen concentration of the infusion based on a signal output from the sensor, or a functional unit realized by executing a program by a CPU or the like. By detecting the oxygen concentration of the infusion, it is possible to control the oxygen concentration of the infusion.

[0065] The oxygen concentration detection unit 32 may detect the oxygen concentration of the infusion solution based on a signal sent from an oxygen concentration sensor 32a (see FIG. 1) installed in the infusion solution container 7. For example, the oxygen concentration sensor 32a may be attached to the catheter 6 (see FIG. 1) and installed in the infusion solution container 7 by attaching the catheter 6 to the infusion solution container 7 (see FIG. 1). In this case, the catheter 6 may be equipped with the oxygen concentration sensor 32a. The type of the oxygen concentration sensor 32a is not important as long as it can be guaranteed to be clean.

[0066] The temperature detection unit 33 may be a sensor that detects the temperature of the infusion liquid, a circuit that detects the temperature of the infusion liquid based on a signal output from the sensor, or a functional unit realized by executing a program by a CPU, etc. By detecting the oxygen concentration of the infusion liquid, it is possible to control the oxygen concentration of the infusion liquid.

[0067] The temperature detection unit 33 may detect the oxygen concentration of the infusion solution based on a signal sent from a temperature sensor 33a (see FIG. 1) installed in the infusion solution container 7 (see FIG. 1), for example. The temperature sensor 33a may be attached to the catheter 6 (see FIG. 1) and installed in the infusion solution container 7 by attaching the catheter 6 to the infusion solution container 7. In this case, the catheter 6 may be equipped with the temperature sensor 33a. The type of the temperature sensor 33a is not important as long as it can be kept clean.

[0068] The remaining amount detection unit 34 may be a sensor that detects the remaining amount of infusion in the infusion container 7, a circuit that detects the temperature of the infusion based on a signal output from the sensor, or a functional unit realized by the execution of a program by a CPU, etc. By detecting the remaining amount of infusion, the oxygen concentration of the infusion can be appropriately controlled.

[0069] The remaining amount detection unit 34 may detect the remaining amount of infusion liquid based on, for example, a sensor (not shown) that detects the weight of the infusion container 7 (see FIG. 1) or a signal sent from the sensor, or, when a supply device (not shown) such as an infusion pump is used to administer the infusion liquid, may calculate and detect the remaining amount of infusion liquid based on the operating state of the supply device. As a specific example, the remaining amount of infusion liquid may be calculated backward from the integrated number of rotations of the infusion pump.

[0070] The biometric information acquisition unit 35 may be a sensor that acquires biometric information such as SpO2, respiratory rate and volume, heart rate, blood pressure, electrocardiogram, electroencephalogram, brain waves, inhaled oxygen concentration, tissue oxygen saturation, arterial blood oxygen partial pressure, mixed venous blood oxygen saturation, urinary oxygen partial pressure, intravesical pressure, cerebral and tissue oxygen saturation, urine volume, cardiac output, body temperature, sweating state, patient movement, and patient image, or a circuit that detects the temperature of the infusion based on signals output from the sensor, or a functional unit implemented by executing a program on a CPU or the like. The use of biometric information enables appropriate control of the oxygen concentration of the infusion based on the patient's condition. The sensor that acquires biometric information may be any medical device that acquires biometric information of a patient. One example of a sensor that acquires biometric information is an arterial blood oxygen saturation sensor 35a (see FIG. 3 ), such as a pulse oximeter, that acquires the patient's SpO2.

[0071] 1 and 2 notifies the user of the operating status of the infusion oxygenation device 100 and notifications from the infusion oxygenation device 100. In this embodiment, the notification unit 90 has a display unit 91, such as a liquid crystal monitor, that notifies by display, and an audio output unit 92, such as a speaker, that notifies by audio, as shown in FIG.

[0072] As an example, as shown in FIG. 6, the display unit 91 displays the gas type (as shown in FIG. 6, O ２ ), the rate at which oxygen is supplied to the infusion (O2 gas flow rate), the time during which the oxygen-containing gas has been supplied (Flowing Duration), the internal pressure of the infusion container 7 (P in bag), and the estimated remaining time for which the oxygen-containing gas is to be supplied (Rest of Duration) may be displayed.

[0073] As another example, the display unit 91 may display information such as a graph of the oxygen partial pressure of the infusion fluid (oxygen partial pressure, pO2 in fluid) and a graph of arterial blood oxygen saturation (SpO2) along with the supply rate of the oxygen-containing gas (Gas Flow Rate), as shown in FIG. 7.

[0074] As another example, the display unit 91 may display information such as the supply rate of oxygen-containing gas (Gas Flow Rate), the partial pressure of oxygen in the infusion fluid (pO2 in fluid), the operating status of the infusion pump (see FIG. 3) or the administration rate of the infusion fluid, the oxygen concentration in the inhaled gas (FiO2, fraction of inspiratory oxygen), and SpO2, as shown in FIG. 8.

[0075] Additionally, the display unit 91 may display information related to general information or medical information, such as the date, time, patient identification information, and attending physician identification information.

[0076] The audio output unit 92 may output audio information about the status of the infusion oxygenation device 100. The audio output unit 92 may emit an alarm sound when an abnormality occurs.

[0077] 1 and 2 is an interface that accepts input of an operation command (e.g., an instruction to start supplying an oxygen-containing gas) from a user. The input unit 95 may be a connection interface for an input device, a functional unit that accepts input of an operation command via the communication unit W, or an input sensor such as a touch panel provided on the display unit 91. In the present embodiment, as an example, the display unit 91, which is a liquid crystal monitor, has a touch panel function and also serves as the input unit 95. The display unit 91 may display, as the input unit 95, an image that serves as an operation interface for issuing an instruction to start or end supplying an oxygen-containing gas or for changing other settings, separately from or simultaneously with the various information shown in FIGS. 6 to 8.

[0078] The specific operation of the infusion oxygenation device 100 will be described below.

[0079] The control unit C shown in Fig. 2 can control the supply of oxygen-containing gas by the gas supply unit 21 based on the internal pressure of the infusion container 7 (see Fig. 1) detected by the container pressure detection unit 31. The control unit C controls the supply of oxygen-containing gas by the gas supply unit 21 based on the internal pressure of the infusion container 7 so as to prevent the infusion container 7 from bursting or the infusion from the infusion container 7 from being administered to the patient at an excessively high rate. For example, when the internal pressure of the infusion container 7 becomes too high, the control unit C reduces the supply rate of oxygen-containing gas to the gas supply unit 21 to prevent the infusion container 7 from bursting or the infusion from the infusion container 7 from being administered to the patient at an excessively high rate, while continuing the supply of oxygen to the patient.

[0080] The controller C may control the supply of oxygen-containing gas by the gas supply unit 21 based on the oxygen concentration of the infusion liquid detected by the oxygen concentration detection unit 32. For example, if the oxygen concentration of the infusion liquid is lower than a predetermined target value, the controller C may increase the supply rate of the oxygen-containing gas by the gas supply unit 21. This promotes dissolution of oxygen into the infusion liquid, increasing the oxygen concentration of the infusion liquid and preventing a shortage of oxygen supplied to the patient. For example, if the oxygen concentration of the infusion liquid is higher than a predetermined target value, the controller C may decrease the supply rate of the oxygen-containing gas by the gas supply unit 21. This reduces the oxygen concentration of the infusion liquid. This also prevents accidents such as air embolism caused by bubbles being generated in the patient's body (blood vessels). Instead of decreasing the supply rate of the oxygen-containing gas by the gas supply unit 21, the controller C may decrease the oxygen concentration of the supply gas. For example, this can be achieved by mixing nitrogen, argon, carbon dioxide, nitric oxide, laughing gas, or air with the supply gas and controlling the mixing ratio.

[0081] The control unit C may adjust the internal pressure of the infusion container 7 (see FIG. 1 ) using the pressure regulator 25 based on the oxygen concentration of the infusion detected by the oxygen concentration detector 32. For example, if the oxygen concentration of the infusion is lower than a predetermined target value, the control unit C may increase the internal pressure of the infusion container 7 using the pressure regulator 25. This promotes dissolution of oxygen into the infusion, increasing the oxygen concentration of the infusion and preventing a shortage of oxygen supplied to the patient. For example, if the oxygen concentration of the infusion is higher than a predetermined target value, the control unit C may decrease (depressurize) the internal pressure of the infusion container 7 using the pressure regulator 25. This reduces the oxygen concentration of the infusion. This also prevents accidents such as air embolism caused by the generation of air bubbles inside the patient's body (blood vessels).

[0082] The control unit C may control the supply of oxygen-containing gas by the gas supply unit 21 based on the temperature of the infusion liquid detected by the temperature detection unit 33. For example, if the temperature of the infusion liquid is higher than a reference temperature, the control unit C may increase the supply rate of the oxygen-containing gas by the gas supply unit 21. This makes it possible to avoid a decrease in the oxygen concentration of the infusion liquid due to an increase in the temperature of the infusion liquid and to avoid a shortage of oxygen supplied to the patient. If the temperature of the infusion liquid is lower than the reference temperature, the control unit C may decrease the supply rate of the oxygen-containing gas by the gas supply unit 21. This makes it possible to avoid an excessive increase in the oxygen concentration of the infusion liquid due to a decrease in the temperature of the infusion liquid.

[0083] The control unit C may control the supply of oxygen-containing gas by the gas supply unit 21 based on the remaining amount of infusion liquid detected by the remaining amount detection unit 34. This makes it possible to prevent the consumption of oxygen-containing gas that does not contribute to administration to the patient, i.e., to prevent wasteful consumption of oxygen-containing gas.

[0084] The control unit C may control the supply of oxygen-containing gas by the gas supply unit 21 based on the biological information acquired by the biological information acquisition unit 35. The control unit C may also adjust the internal pressure of the infusion container 7 by the pressure adjustment unit 25 based on the biological information acquired by the biological information acquisition unit 35.

[0085] For example, when the biological information includes information indicating a patient's oxygen deficiency, the control unit C may control the gas supply unit 21 and the pressure adjustment unit 25 to increase the oxygen concentration of the infusion. These controls are as described above, and the control unit C can increase the oxygen concentration of the infusion by increasing the amount of oxygen supply gas supplied by the gas supply unit 21. The control unit C can increase the oxygen concentration of the infusion by increasing the internal pressure of the infusion container 7 (see FIG. 1) using the pressure adjustment unit 25.

[0086] Examples of cases in which the biological information includes information indicating a patient's oxygen deficiency include when the SpO2 value is lower than a predetermined value (e.g., 90), when the SpO2 value does not show a tendency to increase even after a predetermined period of time has passed since the start of infusion supply, or when the SpO2 value shows a tendency to decrease.

[0087] The control unit C may control the gas supply unit 21 and the pressure adjustment unit 25 to reduce the oxygen concentration of the infusion depending on the patient's condition, for example, when the biological information does not include information indicating a patient's oxygen deficiency. These controls are as described above, and the control unit C can reduce the oxygen concentration of the infusion by reducing the amount of oxygen-supply gas supplied by the gas supply unit 21. The control unit C can reduce the oxygen concentration of the infusion by reducing the internal pressure of the infusion container 7 (see FIG. 1) using the pressure adjustment unit 25. The infusion may also be stopped by linking with an infusion pump (see FIG. 3) or the like.

[0088] An example of a case where the biological information does not include information indicating a patient's lack of oxygen is when the SpO2 value is equal to or greater than a predetermined value (for example, 90).

[0089] The method of using the infusion oxygenation device 100 will now be described.

[0090] The infusion oxygenator 100 is used on the premise that an infusion will be administered to a patient. The infusion may contain a drug used in the patient's treatment, or if the purpose is solely to supply oxygen, it may be saline or a similar solution. It is preferable to select an infusion containing water, which can dissolve oxygen. If the infusion contains a drug that should not come into contact with oxygen, the infusion oxygenator 100 should not be used for such an infusion.

[0091] 1, when using the infusion oxygenator 100, first, the catheter 6 is attached to the infusion container 7. Next, the supply of oxygen-containing gas from the infusion oxygenator 100 to the infusion container 7 is started.

[0092] For example, the supply of oxygen-containing gas to the infusion container 7 may be started before the administration of infusion to the patient is started. The supply of infusion should be started after the oxygen concentration of the infusion reaches a predetermined value (the target value required for treatment) depending on the patient's condition. The administration of infusion to the patient is carried out in accordance with common sense in ordinary medical practice. If the administration of infusion takes priority over the administration of oxygen, the administration of infusion to the patient may be started before the supply of oxygen-containing gas to the infusion container 7 is started.

[0093] After the infusion has started, the patient should pay attention to any notifications from the notification unit 90 and take appropriate measures as necessary.

[0094] The medical effects of using the infusion oxygenator 100 will be explained below based on animal experiments.

[0095] Figure 9 shows the results of an animal experiment using a pig as a subject. In this animal experiment, the FiO2 (oxygen concentration in the inhaled gas) of an anesthetized pig was first controlled to approximately 21% of atmospheric level, lowering the pig's SpO2 to 90. The pig's SpO2 was then monitored over time when an oxygenated infusion was administered (see the graph indicated by the open circles and solid line in Figure 9 ) and when no infusion was administered (see the graph indicated by the open triangles and dashed line in Figure 9 ). The observation period was 15 minutes. Lactated Ringer's solution was used as the infusion. As shown in Figure 9 , the experimental results demonstrated that a significant increase in SpO2 was observed when an oxygenated infusion was administered. This demonstrates the effectiveness of oxygen delivery to the subject via oxygenated infusion.

[0096] Second Embodiment The second embodiment is the same as the first embodiment except for the manner in which the internal pressure of the infusion container 7 is detected by the container pressure detection unit 31. Below, the differences from the first embodiment will be described, and a description of the common parts will be omitted.

[0097] As shown in FIG. 10 , in this embodiment, the container pressure detection unit 31 does not need to include a sensor for detecting pressure. In this embodiment, the container pressure detection unit 31 may detect the internal pressure of the infusion container 7 based on a signal sent from a pressure sensor 31a installed in the infusion container 7. As an example, the pressure sensor 31a may be attached to the catheter 6 and installed in the infusion container 7 by attaching the catheter 6 to the infusion container 7. In this case, the catheter 6 may be equipped with the pressure sensor 31a. The type of the pressure sensor 31a is not important as long as it can be kept clean. In this case, the container pressure detection unit 31 can directly detect the internal pressure of the infusion container 7.

[0098] (Third Embodiment) The third embodiment differs from the second embodiment in that the catheter 6 is not provided with an exhaust valve 66, and exhaust from the exhaust pipe 65 is performed via a pressure-regulating exhaust valve 67 (another example of a pressure adjusting unit) provided in the infusion oxygenation device 100, allowing for more precise control of the internal pressure of the infusion container 7 by the infusion oxygenation device 100. The rest is the same as the second embodiment. Below, differences from the second embodiment will be described, and descriptions of common parts will be omitted.

[0099] 11 , in this embodiment, the pressure regulating exhaust valve 67 is provided in the infusion oxygenation device 100. For example, the pressure regulating exhaust valve 67 may be fixed to the housing 10. In addition to the supply tube 16, an exhaust tube 17 is connected to the catheter 6.

[0100] The end of the supply tube 16 opposite to the end connected to the catheter 6 is connected to the gas supply section 1a of the catheter connection section 1. The gas supply section 1a receives an oxygen-containing gas from a gas supply section 21 (see FIG. 2 ) and supplies the oxygen-containing gas to the supply tube 16.

[0101] One end of the exhaust tube 17 is connected to the exhaust pipe 65 (see FIG. 4 ) of the catheter 6, and the other end is connected to the exhaust section 1b of the catheter connection section 1. The exhaust section 1b is connected to a pressure-regulating exhaust valve 67 inside the housing 10, so that the exhaust gas from the exhaust pipe 65 can be discharged to the outside via the pressure-regulating exhaust valve 67.

[0102] In this embodiment, the pressure regulating exhaust valve 67 may be equipped with an actuator and may be capable of adjusting the flow rate of the exhaust gas from the exhaust pipe 65 and the internal pressure of the infusion container 7 based on an operation command from the control unit C. The pressure regulating exhaust valve 67 may be an aperture adjustment valve capable of adjusting the flow rate of the exhaust gas from the exhaust pipe 65 and the internal pressure of the infusion container 7 by adjusting its aperture, and as an example, a needle valve or a diaphragm valve may be adopted. As a result, the control unit C can adjust the internal pressure of the infusion container 7 by controlling the pressure regulating exhaust valve 67, thereby adjusting the efficiency of dissolving oxygen in the infusion and also adjusting the oxygen concentration in the infusion.

[0103] A filter 67a may be provided at the outlet of the pressure adjusting exhaust valve 67 to prevent contamination of the inside of the infusion container 7 from the outside.

[0104] (Explanation of Modifications) (Modification 1) In the above embodiment, a case has been described in which a supply source of oxygen-containing gas (oxygen cylinder B, as an example) is connected to connection portion 8. However, the connection to connection portion 8 is not limited to a supply source of oxygen-containing gas. For example, as shown in Fig. 12, connection portion 8 may include a first connection portion 81 connected to a supply source of a first gas containing oxygen gas, and a second connection portion 82 connected to a supply source of a second gas different from the first gas.

[0105] The connection part 8, i.e., the first connection part 81 and the second connection part 82, is not limited to a so-called gas cylinder, and the first connection part 81 and the second connection part 82 may be connected to, for example, an oxygen-containing gas supply pipe or a pipe for supplying a second gas in a hospital. One or more second connection parts 82 may be provided.

[0106] The second gas may include nitrogen, argon, laughing gas, or carbon dioxide. One or more second gases may be used.

[0107] In this case, the gas supply unit 21 can prepare an oxygen-containing gas by mixing the first gas and the second gas in an arbitrary ratio based on a command from the control unit C (see FIG. 2 ) and supply the oxygen-containing gas to the catheter 6. This makes it possible to prepare an infusion solution containing oxygen and other gases dissolved therein that is suited to the patient's condition. For example, the control unit C can instruct the gas supply unit 21 to prepare an oxygen-containing gas by mixing the first gas and the second gas in an appropriate ratio based on biological information so that the balance of the partial pressures of oxygen, nitrogen, argon, or carbon dioxide dissolved in the infusion solution is suited to the patient's condition.

[0108] (Variation 2) In the above embodiment, it has been described that the control unit C may control the supply of oxygen-containing gas by the gas supply unit 21 based on the temperature of the infusion liquid detected by the temperature detection unit 33. The control unit C may issue a command to an external device to adjust the temperature of the infusion liquid, in addition to controlling the supply of oxygen-containing gas by the gas supply unit 21 based on the temperature of the infusion liquid detected by the temperature detection unit 33, or separately from controlling the supply of oxygen-containing gas by the gas supply unit 21 based on the temperature of the infusion liquid detected by the temperature detection unit 33.

[0109] For example, as shown in FIG. 13, the infusion oxygenation device 100 may have a temperature control signal sending unit 98 that sends a temperature control signal including a command to adjust the temperature of the infusion to an external device.

[0110] The temperature adjustment signal transmitter 98 transmits a temperature adjustment signal including a command to adjust the temperature of the infusion to an external device based on a command from the controller C. In this case, the controller C may cause the temperature adjustment signal transmitter 98 to transmit a temperature adjustment signal based on the temperature of the infusion detected by the temperature detector 33 or the oxygen concentration of the infusion detected by the oxygen concentration detector 32.

[0111] The control unit C may cause the temperature control signal sending unit 98 to send a temperature control signal so that the temperature of the infusion liquid reaches a predetermined target value. This stabilizes the state of the infusion liquid, for example, stabilizing the oxygen concentration in the infusion liquid, thereby enabling safe treatment of the patient.

[0112] If the oxygen concentration of the infusion fluid detected by the oxygen concentration detection unit 32 is high, the control unit C may cause the temperature control signal transmission unit 98 to transmit a temperature control signal including a command to increase the temperature of the infusion fluid. This increases the temperature of the infusion fluid, thereby decreasing the oxygen concentration of the infusion fluid. If the oxygen concentration of the infusion fluid detected by the oxygen concentration detection unit 32 is low, the control unit C may cause the temperature control signal transmission unit 98 to transmit a temperature control signal including a command to decrease the temperature of the infusion fluid. This decreases the temperature of the infusion fluid, thereby increasing the oxygen concentration of the infusion fluid.

[0113] The temperature adjustment signal transmitter 98 may be an electric circuit that transmits a signal including a command to adjust the temperature of the infusion fluid, or a functional unit realized by the execution of a program by a CPU, etc. The signal including the command to adjust the temperature of the infusion fluid may be transmitted to an external device via the communication unit W, or the temperature adjustment signal transmitter 98 may have a connector and transmit the signal via a wired connection to the external device.

[0114] An example of an external device capable of adjusting the temperature of the infusion fluid is a temperature control device (e.g., an electric heater or a cooler) that can be attached to the infusion container 7 (see FIG. 1). This allows the temperature of the infusion fluid to be increased or decreased. If only increasing the temperature of the infusion fluid is sufficient, an external device that heats the infusion tube 75 or the drip tube 76 (see FIG. 3, respectively) may be used. When heating the infusion tube 75, it is preferable to heat the infusion tube 75 on the infusion container 7 side, rather than the drip tube 76 on the patient side. This allows bubbles (excess oxygen removed from the infusion fluid due to the increase in temperature) generated by heating the infusion fluid to be removed (separated from the infusion fluid) by the drip tube 76. Heating the drip tube 76 to increase the temperature of the infusion fluid is usually preferable compared to heating the infusion tube 75. This is because the drip tube 76 has a predetermined container capacity and a long retention time for the infusion fluid, allowing it to be reliably heated to the desired temperature. This allows for more reliable control of the oxygen concentration of the infusion fluid.

[0115] (Variant 3) In the above embodiment, it was explained that the control unit C can control the supply of oxygen-containing gas by the gas supply unit 21 based on the internal pressure of the infusion container 7 detected by the container pressure detection unit 31.

[0116] The control unit C may issue a command to an external device to adjust the internal pressure of the infusion container 7, in addition to controlling the supply of oxygen-containing gas by the gas supply unit 21 based on the internal pressure of the infusion container 7 detected by the container pressure detection unit 31, or separately from controlling the supply of oxygen-containing gas by the gas supply unit 21 based on the internal pressure of the infusion container 7 detected by the container pressure detection unit 31.

[0117] For example, as shown in FIG. 13, the infusion oxygenation device 100 may have a pressure adjustment signal sending unit 99 that sends a pressure adjustment signal including a command to adjust the internal pressure of the infusion container 7 to an external device.

[0118] The pressure adjustment signal sending unit 99 sends a pressure adjustment signal including a command to adjust the internal pressure of the infusion container 7 (see FIG. 1 ) to an external device based on a command from the control unit C. In this case, the control unit C causes the pressure adjustment signal sending unit 99 to send a pressure adjustment signal based on the internal pressure of the infusion container 7 detected by the container pressure detection unit 31 or the oxygen concentration of the infusion detected by the oxygen concentration detection unit 32.

[0119] The control unit C may cause the pressure adjustment signal sending unit 99 to send a temperature adjustment signal so that the internal pressure of the infusion container 7 reaches a predetermined target value. This stabilizes the internal pressure of the infusion container 7 (see FIG. 1), thereby stabilizing, for example, the oxygen concentration of the infusion, and enabling safe treatment of the patient.

[0120] If the oxygen concentration of the infusion liquid detected by the oxygen concentration detection unit 32 is high, the control unit C may cause the pressure adjustment signal transmission unit 99 to transmit a pressure adjustment signal including a command to lower the internal pressure of the infusion liquid container 7 (see FIG. 1). This reduces the internal pressure of the infusion liquid container 7, thereby reducing the oxygen concentration of the infusion liquid. If the oxygen concentration of the infusion liquid detected by the oxygen concentration detection unit 32 is low, the control unit C may cause the pressure adjustment signal transmission unit 99 to transmit a pressure adjustment signal including a command to increase the internal pressure of the infusion liquid container 7. This increases the internal pressure of the infusion liquid container 7, thereby increasing the oxygen concentration of the infusion liquid.

[0121] The pressure adjustment signal sending unit 99 may be an electric circuit that sends a pressure adjustment signal including a command to adjust the internal pressure of the infusion container 7 (see FIG. 1 ), or a functional unit that is realized by the execution of a program by a CPU, etc. The signal including the command to adjust the internal pressure of the infusion container 7 may be sent to an external device via the communication unit W, or the pressure adjustment signal sending unit 99 may have a connector unit and send the signal via a wired connection to the external device.

[0122] Examples of external devices capable of adjusting the internal pressure of the infusion container 7 shown in Figure 1 include a pressure device that compresses and pressurizes the infusion container 7, and a pressure reduction device that has a space to accommodate the infusion container 7 and reduces the pressure inside the infusion container 7 by reducing the pressure in the space.

[0123] If the oxygen concentration of the infusion solution is likely to become high or if it is necessary to quickly reduce the oxygen concentration of the infusion solution when it becomes high, it is recommended to use a pressure reducing device that can reduce the pressure inside the infusion solution container 7 to a pressure lower than atmospheric pressure. When using such a pressure reducing device, the control unit C shown in FIG. 2 may send a temperature adjustment signal to the pressure adjustment signal sending unit 99, which includes a command to reduce the internal pressure of the infusion solution container 7 (see FIG. 1) to a pressure lowering signal, when the oxygen concentration of the infusion solution detected by the oxygen concentration detection unit 32 is higher than a predetermined target value. This makes it possible to control the oxygen concentration of the infusion solution to be low or to prevent an increase in the oxygen concentration of the infusion solution.

[0124] As described above, an infusion oxygenation device and an infusion oxygenation system can be provided that can safely, easily, and quickly supply oxygen to an infusion.

[0125] Other Embodiments (1) In the above embodiment, the oxygen concentration sensor 32a is installed in the infusion container 7. However, the oxygen concentration sensor 32a may be installed in the infusion tube 75 or the drip tube 76 to detect the oxygen concentration of the infusion in the infusion tube 75 or the drip tube 76. This allows the control unit C to perform necessary control based on the oxygen concentration of the infusion immediately before it is administered to the patient.

[0126] (2) In the above embodiment, the temperature sensor 33a is installed in the infusion container 7. However, the temperature sensor 33a may be installed in the infusion tube 75 or the drip tube 76 to detect the temperature of the infusion in the infusion tube 75 or the drip tube 76. This allows the control unit C to perform necessary control based on the temperature of the infusion immediately before it is administered to the patient.

[0127] (3) In the above embodiment, the case where the exhaust gas is exhausted to the outside via the exhaust valve 66 or the pressure regulating exhaust valve 67 has been described. However, a degassing valve may be provided in the infusion container 7 together with the exhaust valve 66 or the pressure regulating exhaust valve 67, or instead of the exhaust valve 66 or the pressure regulating exhaust valve 67, and the exhaust gas may be exhausted from the degassing valve. In this case, the exhaust pipe 65, the exhaust valve 66, and the pressure regulating exhaust valve 67 may be omitted.

[0128] (4) In the above embodiment, the display unit 91, which is a liquid crystal monitor, has a touch panel function and also serves as the input unit 95. As another example of the input unit 95, the infusion oxygenation device 100 may be provided with a voice input unit such as a microphone. That is, the input unit 95 may be configured to accept voice input of instructions from the user.

[0129] (5) In the above embodiment, the catheter 6 has been described as having a double-tube structure. However, the catheter 6 is not limited to having a double-tube structure. For example, the catheter 6 may have the supply tube 62 and the exhaust tube 65 adjacent to each other and integrated together. Alternatively, the supply tube 62 and the exhaust tube 65 may be inserted as completely separate tubes. Furthermore, the supply tube 62 and the exhaust tube 65 may be spaced apart and integrated by bundling them together at their bases (for example, at the portion where the gas tube connection portion 61 is provided).

[0130] (6) In the first embodiment, the container pressure detection unit 31 detects the pressure of the oxygen-containing gas in the supply tube 16 via the tube 13a connected to the pressure detection port 13 provided in the catheter connection part 1, thereby indirectly detecting the internal pressure of the infusion container 7. However, as shown in Figure 14, the pressure detection port 13 may be provided in the infusion container 7 so that the container pressure detection unit 31 can directly detect the internal pressure of the infusion container 7.

[0131] (7) In the above embodiment, the catheter 6 releases and supplies oxygen-containing gas into the infusion solution in the infusion container 7, thereby dissolving oxygen into the infusion solution. The infusion solution may be stirred in the infusion container 7 to promote dissolution of the oxygen-containing gas released by the catheter 6 into the infusion solution. In this case, as shown in FIG. 15 , the infusion solution may be stirred using a stirrer 5 having a stirring paddle 50 for stirring the infusion solution in the infusion container 7 and a drive unit 51, such as a motor, for rotating the stirring paddle 50. The stirring paddle 50 may be inserted into the infusion container 7 through one of the insertion ports of the rubber stopper 70, which serves as a stirrer insertion port 73. This arrangement speeds up oxygen dissolution and ensures the speed at which the predetermined oxygen concentration is reached and the uniformity of the solution. The shape of the stirring paddle 50 is not limited to a paddle shape, and any shape capable of stirring the solution may be used.

[0132] (8) In the above embodiment, as shown in FIG. 1 , the infusion container 7 has a catheter insertion section 71 into which the catheter 6 is inserted and an outlet 72 from which the infusion liquid is discharged. The catheter 6 has a double-tube structure in which the supply tube 62 is an outer tube and the exhaust tube 65 is an inner tube. However, the catheter insertion section 71 and the outlet 72 from which the infusion liquid is discharged are not necessarily separate in the infusion container 7. For example, the catheter insertion section 71 may also function as the outlet 72. In this case, in addition to the supply tube 62 and the exhaust tube 65, the catheter 6 may be provided with an outlet tube that serves as the outlet 72, and the infusion liquid may be discharged from the outlet tube.

[0133] In addition, the configurations disclosed in the above embodiments (including other embodiments, the same applies below) can be applied in combination with configurations disclosed in other embodiments, as long as no contradictions arise. Furthermore, the embodiments disclosed in this specification are examples, and the embodiments of the present disclosure are not limited to these and can be modified as appropriate within the scope of not departing from the purpose of the present disclosure.

[0134] The present disclosure is applicable to infusion oxygenation devices and infusion oxygenation systems.

[0135] DESCRIPTION OF SYMBOLS 1: Catheter connection part 10: Housing 100: Infusion oxygenation device 13: Port 13a: Tube 13b: Pressure sensor connection part 16: Supply tube 17: Exhaust tube 18: Storage part 19: Antenna 1a: Gas supply part 1b: Exhaust part 200: Infusion oxygenation system 21: Gas supply part 25: Pressure adjustment part 31: Container pressure detection part 31a: Pressure sensor 32: Oxygen concentration detection part 32a: Oxygen concentration sensor 33: Temperature detection part 33a: Temperature sensor 34: Remaining amount detection part 35: Biological information acquisition part 35a: Arterial blood oxygen saturation sensor 5: Stirrer 50: Stirring paddle 51: Drive part 6: Catheter 61: Gas tube connection part 62: Supply tube 63 : Gas dispersion mechanism 65 : Exhaust pipe 66 : Exhaust valve 66a : Filter 67 : Pressure regulating exhaust valve (pressure regulating section) 67a : Filter 7 : Infusion container 70 : Rubber stopper section 71 : Catheter insertion section 72 : Discharge port 73 : Stirrer insertion port 75 : Infusion tube 76 : Drip tube 77 : Infusion pump 78 : Clamp 8 : Connection section 81 : First connection section 82 : Second connection section 90 : Notification section 91 : Display section 92 : Audio output section 95 : Input section 98 : Temperature adjustment signal transmission section 99 : Pressure adjustment signal transmission section B : Oxygen cylinder C : Control section H : Liquid level M : Memory section N : Communication path W : Communication section

Claims

1. a catheter connector for connecting a catheter for supplying an oxygen-containing gas to the infusion in the infusion container; a gas supply unit for supplying the oxygen-containing gas to the catheter connection unit; A container pressure detection unit that detects the internal pressure of the infusion container, The gas supply unit controls the supply of the oxygen-containing gas based on the internal pressure detected by the container pressure detection unit.

2. The catheter connection portion is an air supply unit for supplying the oxygen-containing gas into the infusion container; 2. The infusion oxygenation device according to claim 1, further comprising an exhaust section for exhausting air from the inside of the infusion container.

3. Further comprising an oxygen concentration detection unit for detecting the oxygen concentration of the infusion, 3. The infusion oxygenation device according to claim 1, wherein the gas supply unit controls the supply of the oxygen-containing gas based on the oxygen concentration detected by the oxygen concentration detection unit.

4. The infusion container further includes a pressure adjusting unit for adjusting the internal pressure of the infusion container. The infusion oxygenation device according to claim 3 , wherein the pressure adjusting unit adjusts the internal pressure based on the oxygen concentration detected by the oxygen concentration detecting unit.

5. A biological information acquisition unit for acquiring biological information of a patient is further provided, 3. The infusion oxygenation device according to claim 1, wherein the gas supply unit controls the supply of the oxygen-containing gas based on the biological information acquired by the biological information acquisition unit.

6. 6. The infusion oxygenation device according to claim 5, wherein the biological information includes blood oxygen saturation, inhaled oxygen concentration, blood pressure, heart rate, respiratory rate, tissue oxygen saturation, arterial blood oxygen partial pressure, mixed venous blood oxygen saturation, urinary oxygen partial pressure, intravesical pressure, cerebral / tissue oxygen saturation, urine volume, body temperature, or cardiac output.

7. The infusion container further includes a remaining amount detection unit that detects the remaining amount of infusion in the infusion container, 3. The infusion oxygenation device according to claim 1, wherein the gas supply unit controls the supply of the oxygen-containing gas based on the remaining amount of the infusion liquid detected by the remaining amount detection unit.

8. Further comprising a temperature detector for detecting the temperature of the infusion solution; 3. The infusion oxygenation device according to claim 1, wherein the gas supply unit controls the supply of the oxygen-containing gas based on the temperature detected by the temperature detection unit.

9. an oxygen concentration detection unit that detects the oxygen concentration of the infusion; A temperature detection unit that detects the temperature of the infusion; A temperature control signal sending unit that sends a temperature control signal to adjust the temperature of the infusion liquid, 3. The infusion oxygenation device according to claim 1, wherein the temperature control signal sending unit sends the temperature control signal based on the temperature detected by the temperature detection unit or the oxygen concentration detected by the oxygen concentration detection unit.

10. an oxygen concentration detection unit that detects the oxygen concentration of the infusion; and a pressure adjustment signal sending unit that sends a pressure adjustment signal to adjust the internal pressure of the infusion container.

3. The infusion oxygenation device according to claim 1, wherein the pressure adjustment signal sending unit sends the pressure adjustment signal based on the internal pressure detected by the container pressure detection unit or the oxygen concentration detected by the oxygen concentration detection unit.

11. a first connection portion connected to a supply source of a first gas including oxygen gas; a second connection portion connected to a source of a second gas separate from the first gas; The second gas comprises nitrogen, argon, nitric oxide, laughing gas, or carbon dioxide; 3. The infusion oxygenation device according to claim 1, wherein the gas supply unit prepares the oxygen-containing gas by mixing the first gas and the second gas.

12. a catheter for supplying an oxygen-containing gas to the infusion in the infusion container; a gas supply unit for supplying the oxygen-containing gas to the catheter; A container pressure detection unit that detects the internal pressure of the infusion container, The gas supply unit controls the supply of the oxygen-containing gas based on the internal pressure detected by the container pressure detection unit.

13. The catheter comprises: a supply lumen for supplying the oxygen-containing gas into the infusion container; 13. The infusion oxygenation system according to claim 12, further comprising: an exhaust lumen for exhausting air from within the infusion container.