Blood purification device

Abstract

A blood purification device (100) is configured as follows: in a state in which, during a priming step, a space that is in a vein-side blood circuit (112) and that is downstream from a vein-side air trap chamber (117) is replaced with air as a result of a vein connector (119) being connected to a connection port (161) and a vein-side opening / closing valve (112v) being closed, a priming liquid (10) is accumulated in the vein-side air trap chamber (117) and the liquid-surface level thereof can be adjusted.

Description

Blood purification device

[0001] The present invention relates to a blood purification device.

[0002] Japanese Patent Laid-Open Publication No. 09-164197 (Patent Document 1) is a prior art document disclosing a method for controlling the liquid level in a drip chamber connected to an extracorporeal blood circulation circuit. In the drip chamber liquid level control method described in Patent Document 1, fluid is supplied to the drip chamber while the extracorporeal circulation circuit is prevented from substantially expanding due to pressure and while a drain valve and an air valve connected to the drip chamber are closed. In this state, a pressure sensor detects that the pressure in the drip chamber has risen to a set pressure. When the liquid level in the drip chamber has risen to the set level, the supply of fluid is stopped and the air valve is opened, which then discharges pressurized air stored in the drip chamber. When it is detected that the drip chamber is no longer pressurized, the air valve is closed and the drain valve is opened, and then fluid is supplied to discharge the fluid through the drain valve while maintaining the drip chamber at a predetermined liquid level.

[0003] Japanese Patent Application Publication No. 09-164197

[0004] In the drip chamber liquid level control method described in Patent Document 1, the liquid level in the drip chamber is determined as a function of the pressure inside the drip chamber, so the liquid level cannot be accurately adjusted unless the liquid level before adjustment is kept constant at a set level.

[0005] The present invention has been made in consideration of the above problems, and an object of the present invention is to provide a blood purification device that can adjust the liquid level in the drip chamber without being affected by fluctuations in the liquid level before adjustment.

[0006] A blood purification apparatus according to the present invention comprises a blood purifier, an arterial blood circuit, a venous blood circuit, a dialysate supply source, a dialysate line, a blood pump, a priming solution line, a venous air trap chamber, a venous connector, a venous on-off valve, a dialysate pump, a connection port, and a venous supply / exhaust line. The arterial blood circuit is connected to the blood purifier and is provided for introducing blood into the blood purifier. The venous blood circuit is connected to the blood purifier and is provided for discharging blood from the blood purifier. The dialysate supply source supplies fresh dialysate. The dialysate line is connected to the dialysate supply source and allows fresh dialysate supplied from the dialysate supply source and used dialysate used in the blood purifier to flow through. The blood pump is provided in the arterial blood circuit and pumps blood. The priming solution line is connected to the arterial blood circuit and supplies priming solution. The venous air trap chamber is provided in the venous blood circuit. The venous connector is provided in the venous blood circuit and allows access to a vein. The venous on-off valve is provided in the venous blood circuit downstream of the venous air trap chamber and is capable of opening and closing the venous blood circuit. The dialysate pump is provided in the dialysate line and is capable of delivering fresh dialysate and used dialysate. The connection port is provided in the dialysate line and is connectable to the venous connector. The venous supply and exhaust line is connected to the venous air trap chamber and is capable of exhausting air from the venous air trap chamber and supplying air into the venous air trap chamber. During the priming process, the dialysate pump is driven, causing fresh dialysate and used dialysate to intermittently flow through the dialysate line. During the priming process, the blood purification device stores priming solution in the venous air trap chamber while the venous connector is connected to the connection port and the venous on-off valve is closed, replacing the air in the section of the venous blood circuit downstream of the venous air trap chamber with air, thereby adjusting the liquid level.

[0007] In one embodiment of the present invention, the blood purification apparatus includes a first priming step in which the venous connector is connected to the connection port, and the blood pump is driven in the normal direction while the venous on-off valve is opened, thereby priming until a certain amount of priming solution is stored in the venous air trap chamber; a second priming step in which, after the first priming step, the blood pump is stopped and air is supplied from the venous supply / exhaust pipe into the venous air trap chamber to replace the air in the venous air trap chamber and the section of the venous blood circuit downstream of the venous air trap chamber with air; and a second priming step in which, after the second priming step, the venous connector is connected to the connection port, and the blood pump is driven in the normal direction while the venous on-off valve is opened, thereby replacing the air in the venous air trap chamber and the section of the venous blood circuit downstream of the venous air trap chamber with air. The following steps are performed: a third priming step in which the venous on-off valve is closed, the supply of air from the venous supply and exhaust line to the venous air trap chamber is stopped, and the interior of the venous air trap chamber is maintained at atmospheric pressure through the venous supply and exhaust line; a fourth priming step in which, after the third priming step, the blood pump is driven in the normal direction or the air in the venous air trap chamber is exhausted from the venous supply and exhaust line to store priming fluid in the venous air trap chamber and adjust the fluid level; and a fifth priming step in which, after the fourth priming step, the venous on-off valve is opened to prime the section of the venous blood circuit from the venous on-off valve to the venous connector.

[0008] In one embodiment of the present invention, the blood purification device further includes a viscous chamber provided in the dialysate line and capable of storing fresh dialysate and used dialysate. The dialysate pump is a viscous pump connected to the viscous chamber and capable of pumping fresh dialysate and used dialysate.

[0009] According to the present invention, the liquid level in the drip chamber can be adjusted without being affected by fluctuations in the liquid level before adjustment.

[0010] Fig. 1 is a circuit diagram showing the configuration of a blood purification device according to one embodiment of the present invention. Fig. 2 is a circuit diagram showing a state in which a first priming step is being performed in a blood purification device according to one embodiment of the present invention. Fig. 3 is a circuit diagram showing a state in which a second priming step is being performed in a blood purification device according to one embodiment of the present invention. Fig. 4 is a circuit diagram showing a state in which a third priming step is being performed in a blood purification device according to one embodiment of the present invention. Fig. 5 is a circuit diagram showing a state in which a fourth priming step is being performed in a blood purification device according to one embodiment of the present invention.

[0011] A blood purification apparatus according to one embodiment of the present invention will be described below with reference to the drawings. In the following description of the embodiment, the same or corresponding parts in the drawings will be given the same reference numerals, and their description will not be repeated.

[0012] In the following description of the embodiments, a blood purification device used in continuous renal replacement therapy (CRRT) will be described. However, the blood purification device may also be a blood purification device used in any of continuous hemodiafiltration (CHDF), continuous hemofiltration (CHF), continuous hemodialysis (CHD), and slow continuous ultrafiltration (SCUF).

[0013] Fig. 1 is a circuit diagram showing the configuration of a blood purification apparatus according to one embodiment of the present invention. As shown in Fig. 1, the blood purification apparatus 100 according to one embodiment of the present invention includes a blood purifier 120, an arterial blood circuit 111, a venous blood circuit 112, a dialysate supply source 150, a dialysate line 160, a blood pump 113, a priming solution line 130, a venous air trap chamber 117, a venous connector 119, a venous on-off valve 112v, a dialysate pump, a connection port 161, and a venous supply / exhaust line 118.

[0014] In this embodiment, the blood purification apparatus 100 further includes an arterial air trap chamber 114, an arterial connector 116, an arterial supply / exhaust pipe 115, an arterial air valve 115v, a venous air valve 118v, an arterial pressure measuring device 114P, a venous pressure measuring device 117P, a priming solution supply source 140, a priming on-off valve 130v, an atmosphere release valve 21v, an air pump 21p, an arterial protective filter 115f, a venous protective filter 118f, a first powder dissolving device 151, and a second powder dissolving device 152. At least one of these components does not necessarily have to be provided.

[0015] The blood purifier 120 contains a semipermeable membrane, such as a hollow fiber membrane, inside. The blood purifier 120 has a blood inlet 121 and a blood outlet 122. The arterial blood circuit 111 is connected to the blood inlet 121. The venous blood circuit 112 is connected to the blood outlet 122.

[0016] The arterial blood circuit 111 is provided with a blood pump 113 that pumps blood. In the arterial blood circuit 111, an arterial air trap chamber 114 is provided between the blood pump 113 and the blood purifier 120. The arterial air trap chamber 114 is provided with an arterial pressure measuring device 114P that measures the pressure inside the arterial air trap chamber 114. An arterial protective filter 115f is provided between the arterial air trap chamber 114 and the arterial pressure measuring device 114P.

[0017] The arterial connector 116 is provided in the arterial blood circuit 111 and allows access to the artery. Blood collected from the patient's artery through the arterial connector 116 flows through the arterial blood circuit 111, has its pressure measured as it passes through the arterial air trap chamber 114, and then flows into the blood purifier 120 from the blood inlet 121. The arterial air trap chamber 114 is provided to prevent air from mixing with the blood in the arterial blood circuit 111.

[0018] The venous blood circuit 112 is provided with a venous air trap chamber 117. The venous air trap chamber 117 is provided with a venous pressure measuring device 117P that measures the pressure inside the venous air trap chamber 117. A venous protective filter 118f is provided between the venous air trap chamber 117 and the venous pressure measuring device 117P. A venous on-off valve 112v that can open and close the venous blood circuit 112 is provided downstream of the venous air trap chamber 117 in the venous blood circuit 112.

[0019] The venous connector 119 is provided in the venous blood circuit 112 and allows access to a vein. The pressure of blood purified by the blood purifier 120 is measured as it flows through the venous blood circuit 112 and passes through the venous air trap chamber 117, and then the blood is returned to the patient's vein through the venous connector 119. The venous air trap chamber 117 is provided to prevent air from mixing with the blood in the venous blood circuit 112.

[0020] The blood purifier 120 further has a dialysate inlet 124 and a dialysate outlet 123. A first connecting pipe 181 is connected to the dialysate inlet 124. A second connecting pipe 182 is connected to the dialysate outlet 123.

[0021] The priming solution conduit 130 is connected to the arterial blood circuit 111 and supplies the priming solution 10. The priming solution 10 is, for example, physiological saline. The upstream end of the priming solution conduit 130 is connected to a priming solution supply source 140. The priming solution supply source 140 is a bag that stores physiological saline or the like. The priming solution conduit 130 is provided with a priming on-off valve 130v that opens and closes the priming solution conduit 130.

[0022] The arterial supply / exhaust pipe 115 is connected to the arterial air trap chamber 114. The arterial supply / exhaust pipe 115 is provided with an arterial air valve 115v that can open and close the arterial supply / exhaust pipe 115. The arterial supply / exhaust pipe 115 is configured to be able to exhaust air from the arterial air trap chamber 114 and to be able to supply air into the arterial air trap chamber 114.

[0023] The venous supply / exhaust pipe 118 is connected to the venous air trap chamber 117. The venous supply / exhaust pipe 118 is provided with a venous air valve 118v that can open and close the venous supply / exhaust pipe 118. The venous supply / exhaust pipe 118 is configured to be able to exhaust air from the venous air trap chamber 117 and to supply air into the venous air trap chamber 117.

[0024] The section of the arterial supply / exhaust pipe 115 downstream of the arterial air valve 115v and the section of the venous supply / exhaust pipe 118 downstream of the venous air valve 118v are connected to each other by a connecting pipe 20. An air release valve 21v is provided downstream of the connection point of the arterial supply / exhaust pipe 115 with the connecting pipe 20. An air pump 21p is provided downstream of the connection point of the venous supply / exhaust pipe 118 with the connecting pipe 20. The positions of the air release valve 21v and the air pump 21p may be interchanged.

[0025] By providing the arterial side air valve 115v, the venous side air valve 118v, the atmosphere release valve 21v, and the air pump 21p, the arterial side air supply / exhaust pipe 115 can exhaust air from the arterial side air trap chamber 114 and supply air into the arterial side air trap chamber 114, and the venous side air supply / exhaust pipe 118 can exhaust air from the venous side air trap chamber 117 and supply air into the venous side air trap chamber 117.

[0026] Each of the arterial protection filter 115f and the venous protection filter 118f has the function of preventing blood from leaking out of the blood circuit and the function of preventing infection from the pressure measuring device.

[0027] The dialysate supply source 150 supplies fresh dialysate, which is prepared by mixing reverse osmosis water, a first stock solution, and a second stock solution in the dialysate supply source 150.

[0028] The first concentrate solution is a liquid preparation prepared by dissolving a first powder containing at least one of a calcium salt, a magnesium salt, a potassium salt, a sodium salt, and glucose, which are part of the solute components of fresh dialysis fluid, in water. The first concentrate solution is generated by the first powder dissolving device 151. Note that instead of being generated by the first powder dissolving device 151, the first concentrate solution may be generated in advance and stored in the first concentrate solution tank.

[0029] The second concentrate is a liquid preparation prepared by dissolving a second powder containing at least sodium bicarbonate, which is another solute component of fresh dialysate, in water. The second concentrate is generated by the second powder dissolving device 152. Instead of being generated by the second powder dissolving device 152, the second concentrate may be generated in advance and stored in the second concentrate tank.

[0030] The dialysate supply source 150 is connected to each of the first powder dissolving device 151 and the second powder dissolving device 152. The dialysate supply source 150 is supplied with a first stock solution from the first powder dissolving device 151. The dialysate supply source 150 is supplied with a second stock solution from the second powder dissolving device 152. When the first stock solution is stored in the first stock solution tank, the first stock solution is supplied from the first stock solution tank to the dialysate supply source 150. When the second stock solution is stored in the second stock solution tank, the second stock solution is supplied from the second stock solution tank to the dialysate supply source 150.

[0031] The dialysate line 160 is connected to the dialysate supply source 150, and allows the flow of fresh dialysate supplied from the dialysate supply source 150 and used dialysate used in the blood purifier 120. The dialysate line 160 is provided with a dialysate pump that can pump fresh dialysate and used dialysate.

[0032] In this embodiment, the blood purification apparatus 100 is equipped with a viscous control system 170 including a first chamber 171, a second chamber 172, and a viscous pump 173, which is a dialysate pump. The viscous control system 170 is provided in the dialysate line 160. Note that the dialysate pump is not limited to the viscous pump 173, and any pump capable of pumping fresh dialysate and used dialysate may be used.

[0033] Each of the first chamber 171 and the second chamber 172 is a viscous chamber. The viscous chamber includes a fresh dialysate chamber, a used dialysate chamber, and a viscous chamber. The volumes of the fresh dialysate chamber and the used dialysate chamber can be adjusted by pumping silicone oil into and out of the viscous chamber using a viscous pump 173.

[0034] The first connecting pipe 181 is a pipe for supplying fresh dialysate into the blood purifier 120. The first connecting pipe 181 connects the blood purifier 120 and the viscous control system 170. Specifically, the first connecting pipe 181 connects the dialysate inlet 124 of the blood purifier 120 to the fresh dialysate compartments of the first chamber 171 and the second chamber 172 of the viscous control system 170.

[0035] First chamber 171 and second chamber 172 each have a first on-off valve, and when the first on-off valve of first chamber 171 is open, the first on-off valve of second chamber 172 is closed, and when the first on-off valve of first chamber 171 is closed, the first on-off valve of second chamber 172 is open. First connecting pipe 181 is connected to the fresh dialysate compartment in first chamber 171 via the first on-off valve, and is connected to the fresh dialysate compartment in second chamber 172 via the first on-off valve. Thus, first connecting pipe 181 alternately communicates with the fresh dialysate compartments of first chamber 171 and second chamber 172.

[0036] The second connecting pipe 182 carries the used dialysate used in the blood purifier 120. The second connecting pipe 182 connects the blood purifier 120 and the viscous control system 170. Specifically, the second connecting pipe 182 connects the dialysate outlet 123 of the blood purifier 120 to the used dialysate compartments of the first chamber 171 and the second chamber 172 of the viscous control system 170.

[0037] First chamber 171 and second chamber 172 each have a second on-off valve, and when the second on-off valve of first chamber 171 is open, the second on-off valve of second chamber 172 is closed, and when the second on-off valve of first chamber 171 is closed, the second on-off valve of second chamber 172 is open. Second connecting pipe 182 is connected to the used dialysate compartment in first chamber 171 via the second on-off valve, and is connected to the used dialysate compartment in second chamber 172 via the second on-off valve. As a result, second connecting pipe 182 alternately communicates with the used dialysate compartments of first chamber 171 and second chamber 172.

[0038] As described above, the blood purification device 100 according to this embodiment includes viscous chambers capable of storing fresh dialysate and used dialysate, which are provided in the dialysate line 160. The first chamber 171 and the second chamber 172 store fresh dialysate supplied from the dialysate supply source 150 in a fresh dialysate compartment. The first chamber 171 and the second chamber 172 store used dialysate used in the blood purifier 120 in a used dialysate compartment.

[0039] The dialysate pump is a viscous pump 173 connected to the viscous chamber and capable of pumping fresh dialysate and used dialysate. When the viscous pump 173 is driven in the forward direction, silicone oil moves from the viscous chamber of the first chamber 171 to the viscous chamber of the second chamber 172. This generates negative pressure in each of the fresh dialysate chamber and the used dialysate chamber of the first chamber 171. Meanwhile, positive pressure is generated in each of the fresh dialysate chamber and the used dialysate chamber of the second chamber 172.

[0040] As a result, fresh dialysate supplied from the dialysate supply source 150 flows into the fresh dialysate compartment of the first chamber 171, and used dialysate used in the blood purifier 120 flows into the used dialysate compartment of the first chamber 171 through the second connecting pipe 182.

[0041] Next, the viscous pump 173 is driven in the reverse direction, causing the silicone oil to move from the viscous chamber of the second chamber 172 to the viscous chamber of the first chamber 171. This generates negative pressure in each of the fresh dialysate chamber and the used dialysate chamber of the second chamber 172. Meanwhile, positive pressure is generated in each of the fresh dialysate chamber and the used dialysate chamber of the first chamber 171.

[0042] As a result, fresh dialysate supplied from the dialysate supply source 150 flows into the fresh dialysate compartment of the second chamber 172, and used dialysate used in the blood purifier 120 flows into the used dialysate compartment of the second chamber 172 through the second connecting pipe 182. The viscous pump 173 alternately repeats the forward and reverse rotations described above, thereby causing fresh dialysate and used dialysate to flow intermittently through the dialysate pipe 160.

[0043] Connection port 161 is provided in dialysate line 160 and is connectable to venous connector 119. In this embodiment, connection port 161 is provided downstream of the dialysate pump in dialysate line 160. That is, connection port 161 connectable to venous connector 119 is provided downstream of viscous control system 170 in dialysate line 160. The function of the present invention is effectively achieved when connection port 161 is provided downstream of second connection line 182, where pressure fluctuations in dialysate line 160 become greater. Note that connection port 161 may also be provided upstream of the dialysate pump in dialysate line 160. Connecting venous connector 119 to connection port 161 allows priming solution 10 that has flowed into venous blood circuit 112 to be discharged into dialysate line 160 through venous connector 119 and connection port 161.

[0044] The operation of the blood purification device 100 according to this embodiment when performing the priming step will be described below. In the blood purification device 100 according to this embodiment, the dialysate pump is driven during the priming step, causing fresh dialysate and used dialysate to intermittently flow through the dialysate line 160. By continuously driving the dialysate pump during the priming step, the mixed state of the first and second concentrate solutions can be maintained constant, thereby stabilizing the component ratio of the fresh dialysate supplied from the dialysate supply source 150.

[0045] During the priming step, the blood purification device 100 can adjust the liquid level by storing the priming solution 10 in the venous air trap chamber 117 while the venous connector 119 is connected to the connection port 161 and the venous on-off valve 112v is closed, and the section of the venous blood circuit 112 downstream of the venous air trap chamber 117 is replaced with air. Specifically, the blood purification device 100 executes the following first to fifth priming steps during the priming step.

[0046] 2 is a circuit diagram showing the state in which the first priming step is being performed in the blood purification apparatus according to one embodiment of the present invention. As shown in FIG. 2, when the priming step is being performed, the venous connector 119 is connected to the connection port 161.

[0047] In the first priming step, the arterial air valve 115v and the venous air valve 118v are closed, and the venous on-off valve 112v is opened while the blood pump 113 is driven in the forward direction, thereby priming until a certain amount of priming solution 10 is stored in the venous air trap chamber 117. In the first priming step, the priming on-off valve 130v is open, the atmosphere release valve 21v is closed, and the air pump 21p is stopped.

[0048] In the first priming step, the pressure at the connection port 161 fluctuates periodically as the dialysis pump, viscous pump 173, is driven, causing the liquid level of the priming solution 10 stored in the venous air trap chamber 117 to fluctuate up and down.

[0049] 3 is a circuit diagram showing the state in which the second priming step is being performed in the blood purification apparatus according to one embodiment of the present invention. As shown in FIG. 3, during the second priming step, the blood pump 113 is stopped, and the venous air valve 118v is opened while air is supplied from the venous supply / exhaust line 118 into the venous air trap chamber 117, replacing the air in the venous air trap chamber 117 and the section of the venous blood circuit 112 downstream of the venous air trap chamber 117 with air. During the second priming step, the priming on-off valve 130v, the arterial air valve 115v, and the atmosphere release valve 21v are closed, and the air pump 21p is driven in the forward direction to supply air into the venous air trap chamber 117.

[0050] In the second priming step, the priming solution 10 stored in the venous air trap chamber 117 is discharged and replaced with air. The pressure at the connection port 161 fluctuates periodically as the dialysis pump, viscous pump 173, is driven, causing the liquid level of the priming solution 10 to fluctuate up and down in the section of the venous blood circuit 112 downstream of the venous air trap chamber 117. Note that the section of the venous blood circuit 112 from the venous air trap chamber 117 to the venous connector 119 does not need to be completely replaced with air; it is sufficient that no priming solution 10 remains in the venous air trap chamber 117 when the pressure at the connection port 161 is at its highest.

[0051] 4 is a circuit diagram showing the state in which the third priming step is being performed in the blood purification apparatus according to one embodiment of the present invention. As shown in FIG. 4, in the third priming step, the venous on-off valve 112v is closed, and the supply of air from the venous air supply / exhaust line 118 to the venous air trap chamber 117 is stopped, thereby maintaining the inside of the venous air trap chamber 117 at atmospheric pressure through the venous air supply / exhaust line 118. In the third priming step, the priming on-off valve 130v and the arterial air valve 115v are closed, the venous air valve 118v and the atmosphere release valve 21v are open, and the blood pump 113 and the air pump 21p are stopped.

[0052] In the third priming step, the venous on-off valve 112v is closed, and therefore the air pressure in the venous air trap chamber 117 is maintained at atmospheric pressure without being affected by pressure fluctuations at the connection port 161.

[0053] 5 is a circuit diagram showing the state in which the fourth priming step is being performed in the blood purification apparatus according to one embodiment of the present invention. As shown in FIG. 5, in the fourth priming step, the blood pump 113 is driven in the normal direction to store the priming solution 10 in the venous air trap chamber 117 and adjust the liquid level. In the fourth priming step, the priming on-off valve 130v, the arterial air valve 115v, the venous air valve 118v, and the atmosphere release valve 21v are open, and the air pump 21p is stopped.

[0054] In the fourth priming step, instead of driving the blood pump 113 in the forward direction, the air in the venous air trap chamber 117 may be exhausted through the venous supply / exhaust line 118, thereby sucking the priming solution 10 from the venous blood circuit 112 and storing it in the venous air trap chamber 117 to adjust the liquid level. In this case, the venous air valve 118v is open, the priming on-off valve 130v, the arterial air valve 115v, and the atmosphere release valve 21v are closed, the blood pump 113 is stopped, and the air pump 21p is driven in the reverse direction to exhaust the air in the venous air trap chamber 117.

[0055] In the fourth priming step, the venous side opening / closing valve 112v is closed, so the liquid level of the priming solution 10 in the venous side air trap chamber 117 can be adjusted without being affected by pressure fluctuations at the connection port 161.

[0056] 6 is a circuit diagram showing the state in which the fifth priming step is being performed in the blood purification apparatus according to one embodiment of the present invention. As shown in FIG. 6, in the fifth priming step, the venous on-off valve 112v is opened to prime the section of the venous blood circuit 112 from the venous on-off valve 112v to the venous connector 119. In the fifth priming step, the arterial air valve 115v is closed, the priming on-off valve 130v, the venous air valve 118v, and the atmosphere release valve 21v are open, the blood pump 113 is driven in the forward direction, and the air pump 21p is stopped.

[0057] By performing priming as described above, the liquid level in the venous air trap chamber 117 can be adjusted without being affected by fluctuations in the liquid level in the venous air trap chamber 117 before adjustment due to pressure fluctuations at the connection port 161 during the first priming step.

[0058] The embodiments disclosed herein should be considered to be illustrative in all respects and not restrictive. The scope of the present invention is defined by the claims, not by the above description, and is intended to include all modifications within the meaning and scope of the claims.

[0059] 10 priming solution, 20 connecting pipe, 21p air pump, 21v atmospheric release valve, 100 blood purification device, 111 arterial side blood circuit, 112 venous side blood circuit, 112v venous side opening / closing valve, 113 blood pump, 114 arterial side air trap chamber, 114P arterial side pressure measuring device, 115 arterial side supply / exhaust pipe, 115f arterial side protective filter, 115v arterial side air valve, 116 arterial connector, 117 venous side air trap chamber, 117P venous side pressure measuring device, 118 venous side supply / exhaust pipe, 118f venous side protective filter, 118v venous side air valve, 119 venous connector, 120 blood purification device, 121 blood inlet, 122 blood outlet, 123 dialysate outlet, 124 dialysate inlet, 130 priming solution pipe, 130v Priming on-off valve, 140 priming fluid supply source, 150 dialysis fluid supply source, 151 first powder dissolving device, 152 second powder dissolving device, 160 dialysis fluid line, 161 connection port, 170 viscous control system, 171 first chamber, 172 second chamber, 173 viscous pump, 181 first connecting line, 182 second connecting line.

Claims

1. Blood purifier and an arterial blood circuit connected to the blood purifier for allowing blood to flow into the blood purifier; a venous blood circuit connected to the blood purifier for allowing blood to flow out of the blood purifier; a dialysate source that supplies fresh dialysate; a dialysate line connected to the dialysate supply source, through which the fresh dialysate supplied from the dialysate supply source and the used dialysate used in the blood purifier can flow; a blood pump provided in the arterial blood circuit for pumping blood; a priming solution line connected to the arterial blood circuit and supplying a priming solution; a venous air trap chamber provided in the venous blood circuit; a venous connector provided in the venous blood circuit and capable of accessing a vein; a venous on-off valve provided in the venous blood circuit downstream of the venous air trap chamber and capable of opening and closing the venous blood circuit; a dialysate pump provided in the dialysate line and capable of pumping the fresh dialysate and the used dialysate; a connection port provided in the dialysate line and connectable to the venous connector; a venous air supply / exhaust pipe connected to the venous air trap chamber, capable of exhausting air from the venous air trap chamber and supplying air into the venous air trap chamber, During the priming step, the dialysis fluid pump is driven, so that the fresh dialysis fluid and the used dialysis fluid intermittently flow through the dialysis fluid line; a blood purification apparatus in which, during the priming step, the venous connector is connected to the connection port and the venous on-off valve is closed, and the section of the venous blood circuit downstream of the venous air trap chamber is replaced with air, and the priming solution is stored in the venous air trap chamber to adjust the liquid level.

2. In the priming step, a first priming step in which the venous connector is connected to the connection port, and the blood pump is driven in a normal direction while the venous on-off valve is opened, thereby priming until a predetermined amount of the priming solution is stored in the venous air trap chamber; a second priming step of stopping the blood pump after the first priming step and supplying air from the venous supply / exhaust pipe into the venous air trap chamber to replace the air in the venous air trap chamber and the section of the venous blood circuit downstream of the venous air trap chamber with air; a third priming step of closing the venous on-off valve after the second priming step, stopping the supply of air from the venous air supply / exhaust pipe into the venous air trap chamber, and maintaining the interior of the venous air trap chamber at atmospheric pressure through the venous air supply / exhaust pipe; a fourth priming step of, after the third priming step, driving the blood pump in a normal direction or discharging air from the venous air trap chamber through the venous air supply / exhaust pipe to store the priming solution in the venous air trap chamber and adjust the liquid level; a fifth priming step of opening the venous on-off valve after the fourth priming step to prime a section of the venous blood circuit from the venous on-off valve to the venous connector; The blood purification device according to claim 1 , wherein the above-mentioned steps are carried out.

3. a viscous chamber provided in the dialysate line and capable of storing the fresh dialysate and the used dialysate; 3. The blood purification apparatus according to claim 1, wherein the dialysate pump is a viscous pump connected to the viscous chamber and capable of pumping the fresh dialysate and the used dialysate.