Cleaning chromatography packed bed material with the aid of a processing vessel, and said vessel

US12508573B2Active Publication Date: 2025-12-30JEMP HLDG BV
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Patent Information

Application Number
US17/608596
Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
Priority Date
2019-05-03
Filing Date
2020-05-04
Publication Date
2025-12-30
Estimated Expiration
2042-08-24

AI Technical Summary

Technical Problem

The performance of packed beds in liquid chromatography deteriorates over time due to incomplete removal of contamination during cleaning, leading to aging and reduced effectiveness, especially in industrial applications where the beads are expensive and need to be reused multiple times.

Method used

A preparation vessel with a combination of bottom and vertical filters is used to automate and facilitate processing steps such as cleaning, activation, and concentration of the chromatography beads, allowing for efficient liquid exchange and particle separation, minimizing the risk of contamination and extending the lifespan of the beads.

Benefits of technology

The vessel enables faster and more effective cleaning and preparation of chromatography beads, reducing the risk of contamination and extending their usable life, thereby improving the efficiency and cost-effectiveness of chromatography processes.

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Abstract

Packed bed gel material cleaning vessel, has an internal processing volume, to contain the gel, delimited by a circumferential, axially extending, upright vessel wall at both axial ends sealed by a top vessel wall and an opposite bottom vessel wall, the internal processing volume is above 10 litre; sensors of the vessel monitor the filling level of the vessel. A bottom filter completely covers the vessel bottom wall A circumferential, axially extending, cylindrical vertical filter is provided a short radial distance, e.g. between 1 and 20 millimetre internally from, parallel and concentrically with, the upright vessel wall, providing a torus like flow gap concentrical with the upright vessel wall.
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Citation Information

Patent Citations

  • Processing vessel

    EP0619139A1

  • Intelligent system and method for automated packing of chromatography columns

    EP1710005A1

  • Expanded bed chromatographic separation column for biochemical separation process and technical process thereof

    US20130248430A1

  • Annular grinding mill

    US4225092A

  • Chromatography column using horizontal flow

    US4627918A