Sample analyzer, and activation method for electrode assembly of sample analyzer

Abstract

The present application is applicable to the field of in-vitro diagnosis devices. Disclosed are a sample analyzer, and an activation method for an electrode assembly in a sample analyzer. The sample analyzer comprises an electrode assembly, a detection container, a first sample dispensing apparatus, a first liquid dispensing apparatus, a liquid discharge apparatus and a controller. The controller is configured to execute an activation process and execute an electrolyte measurement process, wherein the activation process comprises a plurality of activation cycles, and the electrolyte measurement process comprises at least one electrolyte measurement cycle. Within a single activation cycle, the controller is configured to control the first liquid dispensing apparatus to dispense a first liquid into the detection container, and to control the liquid discharge apparatus to drive an activation liquid in the detection container to flow through a liquid discharge port and the electrode assembly sequentially so as to be discharged, wherein the duration of the activation liquid flowing through the electrode assembly within the single activation cycle is greater than the duration of a liquid under test flowing through the electrode assembly within a single electrolyte measurement cycle. The automatic activation solution in the present application is easily operated and takes a short amount of time.

Description

Sample analyzer and activation method of electrode assembly thereof Technical Field

[0001] The present application relates to the field of in vitro diagnostic equipment, and in particular to a sample analyzer and a method for activating an electrode assembly in the sample analyzer. Background Art

[0002] A sample analyzer provided by the related art includes an electrolyte measurement module, which is a device for measuring the electrolyte content in samples such as serum or urine. The electrolyte measurement module includes a detection container and an electrode assembly, which is used to perform electrolyte measurement on the test liquid flowing out of the detection container. The electrode assembly includes at least one ion-selective electrode (i.e., ISE electrode), which is used to perform electrolyte measurement on the sample. The electrode assembly usually needs to be activated before being unsealed and used.

[0003] In the related art, the activation method of the electrode assembly is: before the electrode assembly is put on the machine, the electrode assembly is manually immersed in a high-concentration salt solution for several hours or overnight. In specific applications, this activation method has the following shortcomings: 1) The activation process is cumbersome, and the operator's understanding may be biased, and misoperation is inevitable. In particular, the immersion time is difficult to control. If the immersion time is too short, the electrode activation effect is not good. If the machine is directly tested, the calibration slope will be low or the potential drift will occur, resulting in low electrolyte measurement results. If the immersion time is too long, the electrode membrane of the electrode assembly may be damaged, thereby reducing the performance of the electrode assembly. 2) It takes a long time. As a common consumable of the electrolyte measurement module, if the electrode assembly cannot be replaced in time once a fault occurs, the efficiency of medical diagnosis will be reduced, the issuance of the calibration report will be delayed, and it is easy to cause delays in the patient's condition. 3) The activation effect of the electrode assembly after water matrix activation is not ideal, which will affect the performance of the electrode assembly.

[0004] Summary of the Invention

[0005] Based on this, the first purpose of the present application is to provide a sample analyzer, which aims to solve the technical problems in the related art of manually activating the electrode assembly of the electrolyte measurement module, which has a cumbersome operation process and a long activation time.

[0006] To achieve the above objectives, the present application provides a sample analyzer comprising:

[0007] An electrode assembly, the electrode assembly being used to perform electrolyte measurement on a liquid to be tested and to activate the electrode assembly using an activation liquid, the liquid to be tested at least containing a sample, and the activation liquid being formed of at least a first liquid;

[0008] a detection container, the detection container having an inner cavity for containing liquid and a liquid discharge port communicating with the inner cavity, the liquid discharge port being used to allow the liquid contained in the inner cavity to flow from the inner cavity to the electrode assembly;

[0009] a first liquid dispensing device, configured to dispense the sample and the first liquid into the inner cavity of the detection container;

[0010] a liquid discharge device, the liquid discharge device being in communication with the electrode assembly and being configured to discharge liquid flowing through the electrode assembly;

[0011] a controller configured to execute an electrolyte measurement process to perform an electrolyte measurement on the liquid to be tested to obtain an electrolyte measurement result of the sample, and execute an activation process to activate the electrode assembly, wherein the electrolyte measurement process includes at least one electrolyte measurement cycle, and the activation process includes multiple activation cycles;

[0012] During a single electrolyte measurement cycle, the controller is configured to: control the first liquid dispensing device to dispense the sample into the inner cavity of the detection container to form the liquid to be measured, control the liquid discharge device to drive the liquid to be measured in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence, and obtain an electrolyte measurement result of the sample based on at least a first electrical parameter of the electrode assembly when the liquid to be measured flows through the electrode assembly;

[0013] During a single activation cycle, the controller is configured to: control the first liquid dispensing device to dispense the first liquid into the inner cavity of the detection container to form the activated liquid, and control the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence to be discharged;

[0014] Wherein, the time length of the activated liquid flowing through the electrode assembly in a single activation cycle is greater than the time length of the test liquid flowing through the electrode assembly in a single electrolyte determination cycle; and / or, the first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample, and a salt solution containing protein.

[0015] As an embodiment, the first liquid dispensing device includes a first sub-liquid dispensing device and a second sub-liquid dispensing device, wherein the first sub-liquid dispensing device is used to distribute the sample into the inner cavity of the detection container, and the second sub-liquid dispensing device is used to distribute the first liquid into the inner cavity of the detection container.

[0016] As an embodiment, the controller is further configured to: control the drainage device to drive the activated liquid in the inner cavity of the detection container to flow through the electrode assembly at a first speed during a single activation cycle; and control the drainage device to drive the liquid to be tested in the inner cavity of the detection container to flow through the electrode assembly at a second speed during a single electrolyte measurement cycle, wherein the first speed is less than the second speed; or

[0017] The controller is further configured to: during a single activation cycle, control the drainage device to drive the activated liquid in the inner cavity of the detection container to flow through the electrode assembly in an intermittent driving manner; and during a single electrolyte measurement cycle, control the drainage device to drive the liquid to be tested in the inner cavity of the detection container to flow through the electrode assembly in a continuous driving manner.

[0018] As an embodiment, the sample analyzer further comprises a diluent dispensing device, the diluent dispensing device being used to dispense the diluent into the inner cavity of the detection container;

[0019] The liquid to be tested is prepared by diluting the sample with the diluent;

[0020] The activation liquid is prepared by diluting the first liquid with the diluent.

[0021] As an embodiment, the liquid to be tested is prepared by diluting the sample with the diluent at a first dilution ratio;

[0022] The activated liquid is prepared by diluting the first liquid with the diluent at a second dilution ratio;

[0023] The second dilution ratio is smaller than the first dilution ratio.

[0024] As an embodiment, the controller is further configured to: obtain a second electrical parameter of the electrode assembly during a process of controlling the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the electrode assembly within at least one activation cycle;

[0025] After the activation process is completed, determining whether the second electrical parameter meets a first preset condition;

[0026] If yes, it is determined that the electrode assembly is activated successfully;

[0027] If not, it is determined that the activation of the electrode assembly has failed.

[0028] As an embodiment, the number of the multiple activation cycles is a first preset number, the number of the at least one activation cycle is a second preset number, and the second preset number is smaller than the first preset number.

[0029] As an embodiment, the last consecutive activation cycles in the activation process are used as the second preset number of activation cycles.

[0030] As an embodiment, the second electrical parameter is an electric potential; after the activation process is completed, determining whether the second electrical parameter meets the first preset condition includes: calculating the first electric potential change parameter based on at least the electric potential corresponding to the second electrical parameter, and determining whether the first electric potential change parameter meets the first preset condition.

[0031] As an embodiment, the first electric potential variation parameter includes the standard deviation of the electric potential, and the first preset condition includes that the standard deviation of the electric potential is within a first preset range; or

[0032] The first potential change parameter includes a coefficient of variation of the potential, and the first preset condition includes that the coefficient of variation of the potential is within a second preset range.

[0033] As an embodiment, the sample analyzer further comprises an internal standard liquid dispensing device, the internal standard liquid dispensing device being used to dispense the internal standard liquid into the inner cavity of the detection container;

[0034] During a single activation cycle, the controller is further configured to: control the internal standard liquid dispensing device to dispense the internal standard liquid into the inner cavity of the detection container, and control the liquid discharge device to drive the reference liquid in the inner cavity of the detection container, which contains at least the internal standard liquid, to flow through the liquid discharge port and the electrode assembly in sequence; and obtain a third electrical parameter of the electrode assembly during the process of controlling the liquid discharge device to drive the reference liquid in the inner cavity of the detection container to flow through the electrode assembly, wherein the third electrical parameter is an electric potential;

[0035] The calculating of the first potential change parameter at least based on the potential corresponding to the second electrical parameter, and judging whether the first potential change parameter satisfies the first preset condition, includes: calculating the first potential change parameter based on the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and judging whether the first potential change parameter satisfies the first preset condition; wherein the first potential change parameter is the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and the first preset condition includes that the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter is within a third preset range; or, the first potential change parameter is the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and the first preset condition includes that the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter is within a fourth preset range;

[0036] During a single electrolyte determination cycle, the controller is further configured to: control the internal standard solution dispensing device to dispense the internal standard solution into the inner cavity of the detection container, control the liquid discharge device to drive a reference solution containing at least the internal standard solution in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence, and obtain a fourth electrical parameter of the electrode assembly during the process of controlling the liquid discharge device to drive the reference solution in the inner cavity of the detection container to flow through the electrode assembly;

[0037] The obtaining of the electrolyte determination result of the sample at least based on the first electrical parameter of the electrode assembly when the liquid to be tested flows through the electrode assembly includes: obtaining the electrolyte determination result of the sample based on the difference between the first electrical parameter and the fourth electrical parameter.

[0038] As an embodiment, the controller is further configured to: in each activation cycle, control the liquid discharge device to drive the activation liquid in the inner cavity of the detection container to flow through the electrode assembly, and obtain the second electrical parameter of the electrode assembly;

[0039] For each activation cycle, determining whether the second electrical parameter meets a second preset condition;

[0040] If yes, it is determined that the activation of the electrode assembly is successful, and the remaining activation cycles in the activation process are stopped;

[0041] If not, continue to execute the next activation cycle until the activation process is completed.

[0042] As an embodiment, the determining whether the second electrical parameter satisfies the second preset condition includes: calculating a second potential change parameter based on at least the second electrical parameter obtained in a third preset number of consecutive activation cycles including the current activation cycle, and determining whether the second potential change parameter satisfies the second preset condition, the second electrical parameter being a potential;

[0043] Among them, the second preset condition includes that the second electric potential change parameter is within a fifth preset range, and the second electric potential change parameter includes any one of the following: the standard deviation of the electric potential corresponding to the second electric parameter, the drift of the electric potential corresponding to the second electric parameter, the deviation of the electric potential corresponding to the second electric parameter relative to the mean, and the coefficient of variation of the electric potential corresponding to the second electric parameter.

[0044] As an embodiment, the sample analyzer further comprises an internal standard liquid dispensing device, the internal standard liquid dispensing device being used to dispense the internal standard liquid into the inner cavity of the detection container;

[0045] During a single activation cycle, the controller is further configured to: control the internal standard liquid dispensing device to dispense the internal standard liquid into the inner cavity of the detection container, and control the liquid discharge device to drive the reference liquid in the inner cavity of the detection container, which contains at least the internal standard liquid, to flow through the liquid discharge port and the electrode assembly in sequence; and obtain a third electrical parameter of the electrode assembly during the process of controlling the liquid discharge device to drive the reference liquid in the inner cavity of the detection container to flow through the electrode assembly, wherein the third electrical parameter is an electric potential;

[0046] The calculating of the second potential change parameter based on at least the second electrical parameter obtained in the third consecutive preset number of activation cycles including the current activation cycle, and judging whether the second potential change parameter meets the second preset condition, includes: calculating the second potential change parameter based on the second electrical parameter and the third electrical parameter obtained in the third consecutive preset number of activation cycles including the current activation cycle, and judging whether the second potential change parameter meets the second preset condition; wherein the second potential change parameter is a potential difference change parameter between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, the second preset condition includes that the potential difference change parameter is within a sixth preset range, and the potential difference change parameter includes any one of the following: the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, the drift of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, the deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter relative to the mean, and the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter.

[0047] As an embodiment, the sample analyzer also includes a display; the controller is further configured to: during the execution of the activation process, control the display to display a real-time monitoring interface during the execution of the activation process, and the real-time monitoring interface is at least used to display the change information of the electrical parameters of the electrode assembly during the execution of the activation process, the electrical parameters include at least one of the potential, impedance, current and power of the electrode assembly, and the change information includes the change curve of the electrical parameters and at least one of the detection values ​​of the electrical parameters.

[0048] As an embodiment, the controller is further configured to: after completing the activation process, control the display to display an activation result interface, and the activation result interface is at least used to display the change information of the electrical parameters of the electrode assembly during the execution of the activation process, the electrical parameters include the potential of the electrode assembly, the standard deviation of the potential, the standard deviation of the potential difference, the coefficient of variation of the potential, the coefficient of variation of the potential difference, impedance, current and power, at least one of which, the change information includes the change curve of the electrical parameter and at least one of the detection value of the electrical parameter.

[0049] In one embodiment, the sample analyzer pre-stores at least one of the following third preset conditions: the sample analyzer is installed and started for a first preset time; the electrode assembly is replaced and the sample analyzer is installed and started for a second preset time; a third preset time has passed since the last activation process was performed; the electrode assembly has not been subjected to electrolyte measurement for a fourth preset time; a preset time point of a preset activation cycle is reached; and information indicating that the electrode assembly needs to be activated is obtained based on an instruction input by an operator through a human-computer interaction device.

[0050] The controller is further configured to execute the activation process when the third preset condition is met.

[0051] As an embodiment, the sample analyzer further includes a reagent dispensing device, a sample dispensing device, and at least one optical measurement device, wherein the sample dispensing device is used to draw a sample from a sample container and distribute it to a reaction container, the reagent dispensing device is used to draw a reagent from a reagent container and distribute it to the reaction container, and the at least one optical measurement device is used to perform optical measurement on a reaction solution made of at least the sample and the reagent;

[0052] The at least one optical measurement device includes at least one of a first optical measurement component, a second optical measurement component, and a third optical measurement component, wherein the first optical measurement component is used to measure immune-related parameters of the reaction solution, the second optical measurement component is used to measure biochemical-related parameters of the reaction solution, and the third optical measurement component is used to measure coagulation-related parameters of the reaction solution;

[0053] The sample dispensing device and the first liquid dispensing device are the same device or two independent devices.

[0054] In a second aspect, the solution provided by the present application is a sample analyzer, comprising:

[0055] An electrode assembly, the electrode assembly being used to perform electrolyte measurement on a liquid to be tested and to activate the electrode assembly using an activation liquid, the liquid to be tested at least containing a sample, and the activation liquid being formed of at least a first liquid;

[0056] a detection container, the detection container having an inner cavity for accommodating liquid and a liquid discharge port communicating with the inner cavity, the liquid discharge port being used to allow the liquid contained in the inner cavity to flow from the inner cavity to the electrode assembly;

[0057] a first liquid dispensing device, configured to dispense the sample and the first liquid into the inner cavity of the detection container;

[0058] a liquid discharge device, the liquid discharge device being in communication with the electrode assembly and configured to discharge liquid flowing through the electrode assembly;

[0059] a controller configured to execute an electrolyte measurement process to perform an electrolyte measurement on the liquid to be tested to obtain an electrolyte measurement result of the sample, and execute an activation process to activate the electrode assembly, wherein the electrolyte measurement process includes at least one electrolyte measurement cycle, and the activation process includes multiple activation cycles;

[0060] During a single electrolyte measurement cycle, the controller is configured to: control the first liquid dispensing device to dispense the sample into the inner cavity of the detection container to form the liquid to be measured, control the liquid discharge device to drive the liquid to be measured in the inner cavity of the detection container to flow through the liquid discharge port and the activated electrode assembly in sequence, and obtain an electrolyte measurement result of the sample based on at least a first electrical parameter of the electrode assembly when the liquid to be measured flows through the electrode assembly;

[0061] During a single activation cycle, the controller is configured to: control the first liquid dispensing device to dispense the first liquid into the inner cavity of the detection container to form the activated liquid, and control the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence to be discharged;

[0062] Wherein, whether the activation of the electrode assembly is successful is determined based on the second electrical parameter of the electrode assembly detected in at least two activation cycles among the multiple activation cycles, and the second electrical parameter is detected in the process of the activation liquid in the inner cavity of the detection container driven by the discharge device to flow through the electrode assembly.

[0063] As an embodiment, the plurality of activation cycles are continuous, or the time interval between each activation cycle and adjacent activation cycles is the same.

[0064] As an embodiment, the controller is further configured to: at the end of activation, determine whether the electrode assembly is successfully activated based on the second electrical parameter of the electrode assembly detected in at least two activation cycles within the plurality of activation cycles;

[0065] Alternatively, in each activation cycle, the second electrical parameter of the electrode assembly is obtained while controlling the discharge device to drive the activation liquid in the inner cavity of the detection container to flow through the electrode assembly; for each activation cycle, it is determined whether the second electrical parameter meets the second preset condition; if so, it is determined that the activation of the electrode assembly is successful, and the remaining activation cycles in the activation process are stopped; if not, the next activation cycle is continued until the activation process is completed.

[0066] In a third aspect, the present application provides a sample analyzer, comprising:

[0067] An electrode assembly, the electrode assembly being used to perform electrolyte measurement on a liquid to be tested, the liquid to be tested at least containing a sample;

[0068] a detection container, the detection container having an inner cavity for containing liquid and a liquid discharge port communicating with the inner cavity, the liquid discharge port being used to allow the liquid contained in the inner cavity to flow from the inner cavity to the electrode assembly;

[0069] a first liquid dispensing device, configured to dispense the sample and the first liquid into the inner cavity of the detection container;

[0070] a liquid discharge device, the liquid discharge device being in communication with the electrode assembly and being configured to discharge liquid flowing through the electrode assembly;

[0071] a display, the display being used to at least display an electrolyte measurement result of the sample;

[0072] a controller configured to execute an electrolyte measurement process to perform an electrolyte measurement on the liquid to be tested to obtain an electrolyte measurement result of the sample, and execute an activation process to activate the electrode assembly, wherein the electrolyte measurement process includes at least one electrolyte measurement cycle, and the activation process includes multiple activation cycles;

[0073] During a single electrolyte measurement cycle, the controller is configured to: control the first liquid dispensing device to dispense the sample into the inner cavity of the detection container to form the liquid to be measured, control the liquid discharge device to drive the liquid to be measured in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence, and obtain an electrolyte measurement result of the sample based on at least a first electrical parameter of the electrode assembly when the liquid to be measured flows through the electrode assembly;

[0074] During a single activation cycle, the controller is configured to: control the first liquid dispensing device to dispense the first liquid into the inner cavity of the detection container to form the activated liquid, and control the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence to be discharged;

[0075] The controller is further configured to: during the execution of the activation process, control the display to display a real-time monitoring interface of the execution of the activation process.

[0076] As an embodiment, the real-time monitoring interface is at least used to display information on changes in electrical parameters of the electrode assembly during the execution of the activation process, wherein the electrical parameters include at least one of the potential, impedance, current, and power of the electrode assembly, and the change information includes at least one of a change curve of the electrical parameters and a detected value of the electrical parameters; and / or,

[0077] The controller is also configured to: after completing the activation process, control the display to display an activation result interface, and the activation result interface is at least used to display the change information of the electrical parameters of the electrode assembly during the execution of the activation process, the electrical parameters include the potential of the electrode assembly, the standard deviation of the potential, the standard deviation of the potential difference, the coefficient of variation of the potential, the coefficient of variation of the potential difference, impedance, current and power, at least one of the change information includes the change curve of the electrical parameter and at least one of the detection value of the electrical parameter.

[0078] In a fourth aspect, the present application provides a method for activating an electrode assembly in a sample analyzer, comprising multiple activation cycles, wherein each activation cycle comprises the following steps: controlling a first liquid dispensing device to dispense a first liquid into a detection container, controlling a liquid discharge device to drive an activated liquid containing at least the first liquid in the detection container to flow sequentially through a liquid discharge port of the detection container and the electrode assembly to be discharged;

[0079] The duration of the activation liquid flowing through the electrode assembly in a single activation cycle is longer than the duration of the test liquid containing at least the sample flowing through the electrode assembly in a single electrolyte determination cycle.

[0080] And / or, the first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample, and a saline solution, and the saline solution contains at least protein;

[0081] and / or, during the execution of the activation cycle, controlling the display to display a real-time monitoring interface of the execution of the activation cycle;

[0082] And / or, whether the activation of the electrode assembly is successful is determined based on a second electrical parameter of the electrode assembly detected in at least two activation cycles within the multiple activation cycles, and the second electrical parameter is detected during the process of the activation liquid in the inner cavity of the detection container driven by the liquid discharge device to flow through the electrode assembly.

[0083] It can be seen from the above embodiments that the sample analyzer and the activation method of the electrode assembly in the sample analyzer provided by the present application configure the activation process in the controller so that the activation of the electrode assembly can be automatically performed under the control of the controller. Compared with the manual activation scheme in the related art, the automatic activation scheme of the present application has the advantages of simple operation and short time. In addition, the automatic activation can ensure the consistency of the activation effect of the electrode assembly and avoid the influence of human factors caused by the operation of different operators. In addition, the present application can shorten the activation time of the electrode assembly by setting the time for the activation liquid to flow through the electrode assembly in a single activation cycle to be longer than the time for the test liquid to flow through the electrode assembly in a single electrolyte determination cycle.

[0084] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0085] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following is a brief introduction to the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0086] FIG1 is a schematic diagram of the liquid circuit of the electrolyte measurement part of the sample analyzer provided in Example 1 of the present application;

[0087] FIG2 is a schematic diagram of a process for automatically performing activation of an electrode assembly according to Example 1 of the present application;

[0088] FIG3 is a schematic diagram of the electrode assembly activation process provided in Example 1 of the present application;

[0089] FIG4 is a schematic diagram of an electrode assembly diagnostic process provided in Example 1 of the present application;

[0090] FIG5 is a schematic diagram of another electrode assembly diagnostic process provided in Example 1 of the present application;

[0091] FIG6 is a schematic diagram of the electrode assembly activation process provided in Example 3 of the present application;

[0092] FIG7 is a graph showing electrode signals during a single activation cycle according to Example 3 of the present application;

[0093] FIG8 is a graph showing electrode signals during multiple activation cycles according to Example 3 of the present application. Reference numerals: 10, sample analyzer; 100, electrode assembly; 110, ion-selective electrode; 120, reference electrode; 200, detection container; 300, liquid discharge device; 310, liquid discharge power component; 320, waste liquid channel; 500, diluent dispensing device; 600, internal standard liquid dispensing device; 700, first liquid dispensing device; 701, first sub-liquid dispensing device; 702, second sub-liquid dispensing device. DETAILED DESCRIPTION

[0094] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0095] It should be noted that the descriptions of "first", "second", etc. in this application are for descriptive purposes only and should not be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" or "second" may explicitly or implicitly include at least one of such features. In addition, the technical solutions between the various embodiments can be combined with each other, but this must be based on the fact that they can be implemented by ordinary technicians in this field. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0096] The flowcharts shown in the accompanying drawings are for illustrative purposes only and do not necessarily include all contents and operations / steps, nor must they be executed in the order described. For example, some operations / steps may be decomposed, combined, or partially merged, so the actual execution order may vary depending on the actual situation.

[0097] The following describes some embodiments of the present application in detail with reference to the accompanying drawings. In the absence of conflict, the following embodiments and features therein may be combined with each other.

[0098] There are two main reasons why the electrode assembly needs to be activated: (1) When an unactivated electrode assembly is first used, the aqueous solution generally flows through the measurement channel of the electrode assembly. Since the surface of the measurement channel is hydrophobic, it is easier for bubbles to form in the measurement channel of the electrode assembly, resulting in a sudden change in the measured electrode potential signal and unstable measurement results. Therefore, the measurement channel of the electrode assembly needs to be activated. (2) Since the unactivated electrode membrane is stored in a dry environment for a long time, there is a concentration difference between the internal filling liquid in the electrode membrane and the external air. The electrode membrane response is in an unbalanced state, and the resistance of the electrode membrane will be high. When the electrode membrane material is immersed in a certain salt solution, as the immersion time increases, the internal resistance of the electrode membrane will gradually decrease and gradually reach stability. During the activation process of the ion-selective electrode, the electrode membrane contacts the solution, and the target ions diffuse in the electrode membrane. It is considered to be divided into two steps. The first step is from the solution body to the surface of the electrode assembly, and the second step is the diffusion from the surface of the electrode assembly to the electrode membrane. Assuming that when the electrode membrane contacts the solution, the first step is very fast and the second step is a slow process, then the activation process is mainly determined by the second step. The diffusion of target ions into the electrode membrane is equivalent to charging the above circuit. The thickness of the electrode membrane is determined by the time required for activation of the electrode assembly. The thicker the electrode membrane, the longer the activation process.

[0099] Example 1:

[0100] As shown in Figures 1 to 5, the sample analyzer 10 provided in the first embodiment of the present application includes an electrode assembly 100 and a detection container 200. The electrode assembly 100 is used to measure target ions (i.e., electrolyte measurement, which primarily measures the concentration of target ions in the test liquid) in a test liquid flowing out of the detection container 200. The test liquid at least contains a sample. Optionally, the electrode assembly 100 can be activated using an activation liquid, wherein the activation liquid is formed from at least a first liquid.

[0101] In one embodiment, the first liquid is one of a serum control, a plasma control, a serum sample, a plasma sample, and a saline solution, wherein the saline solution contains at least protein. Activating the electrode assembly 100 using any of the serum control, plasma control, serum sample, plasma sample, and a saline solution containing at least protein results in more complete activation, better activation effects, and shorter activation times than activating the electrode assembly 100 using an aqueous matrix solution. This embodiment optimizes and limits the first liquid to ensure effective activation of the electrode assembly 100.

[0102] In one embodiment, the detection container 200 has an inner cavity and a liquid discharge port connected to the inner cavity. The liquid discharge port is used to allow the test liquid to flow from the inner cavity to the electrode assembly 100. The inner cavity provides a storage space for the sample and the test liquid. The electrode assembly 100 is used to measure target ions in the test liquid composed of the sample and the diluent discharged from the liquid discharge port.

[0103] As an embodiment, the sample analyzer 10 further includes a first liquid dispensing device 700, which is used to dispense a first liquid into the inner cavity of the detection container 200, so as to activate the electrode assembly 100 with the first liquid. Furthermore, the first liquid dispensing device 700 is also used to dispense a sample into the inner cavity of the detection container 200.

[0104] It can be understood that dispensing the sample and the first liquid into the detection container 200 can be performed by the same dispensing device or by different dispensing devices.

[0105] Optionally, the first liquid dispensing device 700 includes a first sub-liquid dispensing device 701 and a second sub-liquid dispensing device 702, wherein the first sub-liquid dispensing device 701 is used to dispense the sample into the inner cavity of the detection container 200, and the second sub-liquid dispensing device 702 is used to dispense the first liquid into the inner cavity of the detection container 200.

[0106] In other words, the first sub-liquid dispensing device 701 is primarily used to achieve quantitative sample distribution. For example, the first sub-liquid dispensing device 701 injects the sample into the detection container 200 through a dispensing method. The second sub-liquid dispensing device 702 is used to distribute the first liquid into the inner cavity of the detection container 200. The first liquid is used to activate the electrode assembly 100.

[0107] As an embodiment, the sample analyzer 10 further includes a drain device 300, which is connected to the drain port via the electrode assembly 100. The drain device 300 is configured to sequentially drain the test liquid or activation liquid in the detection container 200 through the drain port and the electrode assembly 100. The activation liquid includes at least a first liquid. The drain device 300 is primarily configured to provide a driving force for the liquid in the detection container 200 to flow out of the drain port and through the electrode assembly 100. In other words, the drain device 300 is connected to the electrode assembly 100 to drain the liquid flowing through the electrode assembly 100.

[0108] As an embodiment, the sample analyzer 10 further includes a controller, which is electrically connected to at least one of the electrode assembly 100 , the first sample dispensing device 400 , the liquid discharge device 300 , and the first liquid dispensing device 700 .

[0109] As an embodiment, the controller is configured to execute an activation process to activate the electrode assembly 100, and execute an electrolyte measurement process to measure the sample to obtain an electrolyte measurement result. The activation process includes multiple activation cycles, and the electrolyte measurement process includes at least one electrolyte measurement cycle. This embodiment configures the activation process in the controller so that the activation of the electrode assembly 100 can be automatically performed under the control of the controller. The automatic activation scheme has the advantages of simple operation and short time. In addition, the automatic activation can ensure the consistency of the activation effect of the electrode assembly 100 and avoid the influence of human factors caused by different operators.

[0110] As an embodiment, during a single activation cycle, the controller is configured to: control the first liquid dispensing device 700 to dispense the first liquid into the inner cavity of the detection container 200 to form an activation liquid; and control the liquid discharge device 300 to drive the activation liquid in the detection container 200 to flow through the liquid discharge port and out of the electrode assembly 100. The activation process primarily involves allowing the activation liquid to flow through the electrode assembly 100 and ensure that the electrode assembly 100 is fully in contact with the activation liquid.

[0111] As one embodiment, during a single electrolyte measurement cycle, the controller is configured to: control the first liquid dispensing device 700 to dispense a sample into the inner cavity of the detection container 200 to form a test liquid; control the liquid discharge device 300 to drive the test liquid in the inner cavity of the detection container 200 to flow sequentially through the liquid discharge port and the activated electrode assembly 100; and obtain an electrolyte measurement result of the sample based on at least a first electrical parameter of the electrode assembly 100 as the test liquid flows through the electrode assembly 100. In this embodiment, using the activated electrode assembly 100 for electrolyte measurement helps ensure the accuracy of the measurement results.

[0112] As one embodiment, the liquid drainage device 300 includes a liquid drainage power unit 310 and a waste liquid channel 320. The liquid drainage power unit 310 is used to drive the liquid in the inner cavity of the detection container 200 to flow through the liquid drainage port, the electrode assembly 100, and then be discharged into the waste liquid channel 320. The liquid drainage power unit 310 is primarily used to provide driving force for the liquid in the detection container 200 to flow out of the liquid drainage port and through the electrode assembly 100. The waste liquid channel 320 is connected to a waste liquid collection container and is used to discharge the liquid discharged by the liquid drainage power unit 310 into the waste liquid collection container.

[0113] In one embodiment, the sample is serum, plasma, urine, or other body fluid. After being collected from a patient, the sample is stored in a sample container. The first sample dispensing device 400 is used to aspirate the sample from the sample container and dispense at least a portion of the aspirated sample into the testing container 200. The sample container is provided with an identification code, which includes at least one of a barcode, a QR code, and a radio frequency code.

[0114] As an embodiment, the duration of the activation liquid flowing through the electrode assembly 100 in a single activation cycle is longer than the duration of the test liquid flowing through the electrode assembly 100 in a single electrolyte measurement cycle. This embodiment can shorten the activation process duration of the electrode assembly 100 by extending the contact time between the activation liquid and the electrode assembly 100.

[0115] In one embodiment, the controller is further configured to: during a single activation cycle, control the drain device 300 to drive the activated liquid in the inner cavity of the detection container 200 to flow through the electrode assembly 100 at a speed that is less than the speed at which the drain device 300 drives the test liquid in the detection container 200 to flow through the electrode assembly 100 during a single electrolyte measurement cycle. That is, the controller is further configured to control the drain device 300 to drive the activated liquid in the inner cavity of the detection container 200 to flow through the electrode assembly 100 at a first speed during a single activation cycle, and to control the drain device 300 to drive the test liquid in the inner cavity of the detection container 200 to flow through the electrode assembly 100 at a second speed during a single electrolyte measurement cycle, wherein the first speed is less than the second speed. This embodiment primarily uses speed control to ensure that the duration of the activated liquid flowing through the electrode assembly 100 during the activation cycle is greater than the duration of the test liquid flowing through the electrode assembly 100 during the electrolyte measurement cycle.

[0116] Of course, in specific applications, the method for making the duration of the activation liquid flowing through the electrode assembly 100 during the activation cycle longer than the duration of the liquid to be tested flowing through the electrode assembly 100 during the electrolyte measurement cycle is not limited to the above-mentioned scheme of speed control. For example, as an alternative embodiment, intermittent control can be used during the activation cycle to achieve the purpose of making the duration of the activation liquid flowing through the electrode assembly 100 during the activation cycle longer than the duration of the liquid to be tested flowing through the electrode assembly 100 during the electrolyte measurement cycle. Specifically, in this alternative embodiment, the controller is further configured to: during a single activation cycle, control the drain device 300 to drive the activation liquid in the inner cavity of the detection container 200 to flow through the electrode assembly 100 in an intermittent driving manner; and during a single electrolyte measurement cycle, control the drain device 300 to drive the liquid to be tested in the inner cavity of the detection container 200 to flow through the electrode assembly 100 in a continuous driving manner.

[0117] As an embodiment, the electrode assembly 100 includes at least one ion selective electrode 110 and a reference electrode 120, and the at least one ion selective electrode 110 includes at least one of a sodium ion selective electrode 110, a chloride ion selective electrode 110, and a potassium ion selective electrode 110. The ion selective electrode 110 (which can be referred to as an ISE electrode, ISE is the abbreviation of Ion Selective Electrode) is mainly composed of an ion selective membrane (which can be referred to as a "selective membrane"), an internal electrolyte solution, and an electrode silver rod composed of silver or silver chloride. In this embodiment, the ion selective electrode 110 and the reference electrode 120 are arranged side by side, and the electrical parameters of the ion selective electrode 110 and the reference electrode 120 are obtained by the liquid to be measured flowing through the ion selective electrode 110 and the reference electrode 120 in sequence. Of course, in specific applications, the arrangement of the electrode assembly 100 is not limited to this.

[0118] As an embodiment, the electrode assembly 100 includes a reference electrode 120, a sodium ion selective electrode 110, a chloride ion selective electrode 110, and a potassium ion selective electrode 110. In this embodiment, the sodium ion concentration, the chloride ion concentration, and the potassium ion concentration of the sample can be measured.

[0119] As an embodiment, the electrode assembly 100 further includes a measurement channel, wherein the liquid discharge port is connected to the measurement channel. The reference electrode 120 and the ion selective electrode 110 are at least partially disposed within the measurement channel, so that liquid flowing through the measurement channel can contact the reference electrode 120 and the ion selective electrode 110.

[0120] As one embodiment, the sample analyzer 10 further includes a diluent dispensing device 500 for dispensing a diluent into the inner cavity of the detection container 200. The test liquid is prepared by diluting the sample with the diluent, and the activating liquid is prepared by diluting the first liquid with the diluent. In this embodiment, when performing an electrolyte measurement, the sample is first diluted with the diluent to obtain the test liquid. This indirect method is used to measure the target ion concentration in the sample, which has the beneficial effects of reducing sample consumption and reducing the impact of substances such as proteins and lipids in the sample on the measurement results.

[0121] In one embodiment, the test liquid is prepared by diluting the sample with a diluent at a first dilution ratio; the activation liquid is prepared by diluting the first liquid with a diluent at a second dilution ratio; the second dilution ratio is lower than the first dilution ratio. Using a higher concentration of activation liquid to activate the electrode assembly 100 can shorten the dilution and activation times.

[0122] As an embodiment, the controller is further configured to: during at least one of the activation cycles, control the discharge device 300 to drive the activation liquid in the inner cavity of the detection container 200 to flow through the electrode assembly 100, and obtain a second electrical parameter of the electrode assembly 100; after the activation process is completed, determine whether the second electrical parameter meets the first preset condition; if so, determine that the activation of the electrode assembly 100 is successful; if not, determine that the activation of the electrode assembly 100 has failed. After the activation process is completed, the diagnostic process is automatically entered to determine whether the activation is successful. In this embodiment, based on the second electrical parameter of the electrode assembly 100 collected during the activation process, whether the activation is successful is determined, thereby ensuring the stability and reliability of the activation effect of the electrode assembly 100.

[0123] It is understood that, in this specification, whether activation is successful includes at least whether activation of the electrode assembly 100 is successful, and activation failure includes at least activation failure of the electrode assembly 100. Similarly, activation success includes at least successful activation of the electrode assembly 100. As an embodiment, the activation process includes a first preset number of activation cycles, that is, the number of cycles corresponding to the multiple activation cycles is the first preset number; the number of the multiple activation cycles is the first preset number, and the number of the at least one activation cycle is the second preset number, which is less than the first preset number.

[0124] After the activation process is completed, determining whether the second electrical parameter meets the first preset condition includes: after completing the first preset number of activation cycles, measuring the second electrical parameter based on the second preset number of activation cycles, and determining whether the first preset condition is met; wherein the second preset number is less than the first preset number. This embodiment uses whether the first preset number of activation cycles has been completed as the basis for determining whether to stop the activation process, which helps prevent the undesirable phenomenon of the activation process looping out of control. In addition, this embodiment uses the second electrical parameter of the second preset number of activation cycles that is less than or equal to the first preset number as the basis for diagnosing the electrode assembly 100.

[0125] In one embodiment, the second preset number is less than the first preset number, i.e., the second electrical parameters of a second preset number of activation cycles, which are less than or equal to the first preset number, are used as the basis for diagnosing the electrode assembly 100. This helps reduce the amount of computation required. In one embodiment, determining whether the first preset condition is satisfied based on the second electrical parameters measured during the second preset number of activation cycles includes determining whether the first preset condition is satisfied based on the second electrical parameters measured during the last second preset number of activation cycles in the activation process. Optionally, the last consecutive activation cycles in the activation process are used as the second preset number of activation cycles.

[0126] The second electrical parameter measured based on the activation cycle at the end of the activation process will be more stable than the second electrical parameter measured at the activation cycle at the beginning of the activation process. In this embodiment, the second electrical parameter measured at the end of the second preset number of activation cycles is used as the basis for judging whether the activation is successful, which is beneficial for ensuring the reliability of the judgment result and reducing the amount of calculation. The second preset number of activation cycles at the end of the activation process is the last second preset number of activation cycles in the activation process. For example, if the activation process includes 100 activation cycles and the second preset number is 20, the second electrical parameter measured at the end of the second preset number of activation cycles in the activation process is the second electrical parameter measured at the last 20 activation cycles.

[0127] As an embodiment, the sample analyzer 10 also includes an internal standard liquid dispensing device 600, which is used to dispense internal standard liquid into the detection container 200; during the electrolyte determination cycle, the controller is further configured to: obtain a first electrical parameter of the electrode assembly 100 while controlling the drainage device 300 to drive the liquid to be tested in the detection container 200 to flow through the electrode assembly 100; control the internal standard liquid dispensing device 600 to dispense internal standard liquid into the detection container 200, control the drainage device 300 to drive the reference liquid in the detection container 200 containing at least the internal standard liquid to flow through the drainage port and the electrode assembly 100 in sequence, and obtain a fourth electrical parameter of the electrode assembly 100 while controlling the drainage device 300 to drive the reference liquid in the detection container 200 to flow through the electrode assembly 100; and obtain the electrolyte determination result of the sample based on the difference between the first electrical parameter and the fourth electrical parameter. That is, the controller executes at least a first electrical parameter of the electrode assembly when the test liquid flows through the electrode assembly to obtain an electrolyte measurement result of the sample, including: obtaining the electrolyte measurement result of the sample based on the difference between the first electrical parameter and the fourth electrical parameter. In this embodiment, the electrical parameters obtained during the electrolyte measurement are calculated based on the electrical parameters of the electrode assembly 100 when the test liquid and the reference liquid flow through the electrode assembly 100, respectively. This can make the electrolyte measurement result of the sample more accurate and the measurement speed faster.

[0128] As an embodiment, within a single activation cycle, the controller is configured to: control the internal standard liquid dispensing device 600 to distribute the internal standard liquid into the detection container 200, control the drainage device 300 to drive the reference liquid containing at least the internal standard liquid in the detection container 200 to flow through the drainage port and the electrode assembly 100 in sequence; in the process of controlling the drainage device 300 to drive the reference liquid in the detection container 200 to flow through the electrode assembly 100, obtain the third electrical parameter of the electrode assembly 100, the third electrical parameter is the electric potential; the first electric potential change parameter is the electric potential difference change parameter between the second electric parameter and the third electric parameter. In this embodiment, the electrical parameters obtained during the activation process are calculated based on the electrical parameters of the electrode assembly 100 when the activation liquid and the reference liquid flow through the electrode assembly 100 respectively. This can correspond to the data analysis method of the electrolyte determination on the one hand, and on the other hand, it can make the activation effect of the electrode assembly 100 more reliable and the activation speed faster.

[0129] In one embodiment, the first potential variation parameter is the coefficient of variation CV of the potential difference between the second electrical parameter and the third electrical parameter, and the first preset condition includes the coefficient of variation of the potential difference between the second electrical parameter and the third electrical parameter being within a fourth preset range. In this embodiment, the coefficient of variation CV of the potential difference is used as the basis for determining whether activation is successful. The coefficient of variation CV of the potential difference can be calculated from the standard deviation SD of the potential difference. The calculation formulas for CV and SD are as follows:

[0130] Among them, E S-B is the potential difference between the activation liquid flowing through the electrode assembly 100 and the reference liquid flowing through the electrode assembly 100, The average value of the potential difference between the activation liquid flowing through the electrode assembly 100 and the reference liquid flowing through the electrode assembly 100 is measured for the second preset number of activation cycles. Of course, in specific applications, the coefficient of variation (CV) of the potential difference serves as the basis for determining whether the activation is successful. For example, as an alternative embodiment, the standard deviation (CD) of the potential difference may also be used as the basis for determining whether the activation is successful. That is, the first potential variation parameter is the standard deviation of the potential difference between the second electrical parameter and the third electrical parameter, and the first preset condition includes the standard deviation of the potential difference between the second electrical parameter and the third electrical parameter being within a third preset range.

[0131] As an embodiment, the controller is further configured to: after completing the first preset number of activation cycles, if it is determined that the activation has failed, output a warning signal of activation failure and / or re-execute the activation process. That is, if the activation of the electrode assembly 100 fails, output a warning signal of activation failure and / or re-execute the activation process. As an embodiment, the first preset number and the second preset number are fixed values ​​and cannot be adjusted manually, that is, the number of activation cycles of the activation process cannot be adjusted manually. Of course, in a specific application, as an alternative embodiment, the first preset number and the second preset number can also be set to a manually adjustable manner. Specifically, in this alternative embodiment, the sample analyzer 10 also includes a human-computer interaction device, and the controller is further configured to: adjust the first preset number and / or the second preset number according to the instructions input by the operator through the human-computer interaction device.

[0132] As an embodiment, the sample analyzer 10 pre-stores at least one of the following third preset conditions: the sample analyzer 10 is installed and started for a first preset time, the electrode assembly 100 is replaced, and the sample analyzer 10 is installed and started for a second preset time, and a third preset time has passed since the last activation process was executed; the continuous time or duration during which the electrode assembly 100 does not perform electrolyte measurement reaches a fourth preset time; the preset time point of the preset activation cycle is reached; information that the electrode assembly 100 needs to be activated is obtained based on instructions input by the operator through the human-computer interaction device; the controller is further configured to: execute the activation process when any of the third preset conditions is met.

[0133] In one embodiment, the sample analyzer 10 further includes a reagent dispensing device, a second sample dispensing device, and at least one optical measurement device. The second sample dispensing device is configured to draw a sample from a sample container and dispense it into a reaction container. The reagent dispensing device is configured to draw a reagent from a reagent container and dispense it into the reaction container. The optical measurement device is configured to optically measure a reaction solution composed of at least the sample and the reagent. The at least one optical measurement device includes at least one of a first optical measurement component, a second optical measurement component, and a third optical measurement component. The first optical measurement component is configured to measure immune-related parameters of the reaction solution, the second optical measurement component is configured to measure biochemical-related parameters of the reaction solution, and the third optical measurement component is configured to measure coagulation-related parameters of the reaction solution. The second sample dispensing device and the first sample dispensing device 400 may be the same device or two independent devices. In this embodiment, in addition to integrating an electrolyte measurement function, the sample analyzer 10 also integrates at least one of a biochemical measurement function, an immunoassay function, and a coagulation measurement function. That is, the electrolyte measurement module can be integrated into a biochemical analyzer, an immunoassay analyzer, or a coagulation analyzer. This facilitates the diversification of the functions of the sample analyzer 10. Of course, in a specific application, as an alternative implementation, the sample analyzer 10 may also have only the electrolyte measurement function, that is, the sample analyzer 10 may be a standalone electrolyte measurement device.

[0134] The activation method for the electrode assembly 100 in the sample analyzer 10 provided in this embodiment includes multiple activation cycles, and a single activation cycle includes the following steps: controlling the first liquid dispensing device 700 to dispense the first liquid into the detection container 200, and controlling the liquid discharge device 300 to drive the activation liquid containing at least the first liquid in the detection container 200 to flow through the liquid discharge port of the detection container 200 and the electrode assembly 100 in sequence to be discharged; wherein, the time for the activation liquid to flow through the electrode assembly 100 in a single activation cycle is greater than the time for the liquid to be tested containing at least the sample to flow through the electrode assembly 100 in a single electrolyte determination cycle.

[0135] As an embodiment, the method for implementing the time length of the activated liquid flowing through the electrode assembly 100 in a single activation cycle being longer than the time length of the liquid to be tested flowing through the electrode assembly 100 in a single electrolyte measurement cycle includes: controlling the speed at which the drainage device 300 drives the activated liquid in the detection container 200 to flow through the electrode assembly 100 in a single activation cycle being less than the speed at which the drainage device 300 drives the activated liquid in the detection container 200 to flow through the electrode assembly 100 in a single electrolyte measurement cycle.

[0136] Alternatively, as another embodiment, the method for realizing that the time length of the activated liquid flowing through the electrode assembly 100 in a single activation cycle is longer than the time length of the liquid to be tested flowing through the electrode assembly 100 in a single electrolyte measurement cycle includes: in a single activation cycle, controlling the drainage device 300 to drive the activated liquid in the detection container 200 to flow through the electrode assembly 100 in an intermittent driving manner; in a single electrolyte measurement cycle, controlling the drainage device 300 to drive the activated liquid in the detection container 200 to flow through the electrode assembly 100 in a continuous driving manner.

[0137] As an embodiment, the first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample and a saline solution, and the saline solution contains at least protein.

[0138] As an embodiment, before controlling the first liquid dispensing device 700 to dispense the first liquid into the detection container 200 and controlling the liquid discharge device 300 to drive the activated liquid containing at least the first liquid in the detection container 200 to flow through the liquid discharge port of the detection container 200 and the electrode assembly 100 in sequence, a single activation cycle also includes the following steps: controlling the diluent dispensing device 500 to dispense the diluent into the detection container 200.

[0139] As an embodiment, the test liquid is prepared by diluting the sample with a diluent at a first dilution ratio; the activation liquid is prepared by diluting the first liquid with the diluent at a second dilution ratio; and the second dilution ratio is smaller than the first dilution ratio.

[0140] As an embodiment, a single activation cycle also includes the following steps: in the process of controlling the discharge device 300 to drive the activated liquid in the detection container 200 to flow through the electrode assembly 100, obtaining the second electrical parameter of the electrode assembly 100; the activation method also includes the following steps: after multiple activation cycles are completed, judging whether the first preset condition is met based on the second electrical parameter; if so, determining that the activation is successful; if not, determining that the activation has failed.

[0141] As an embodiment, a single activation cycle also includes the following steps: in the process of controlling the discharge device 300 to drive the activated liquid in the detection container 200 to flow through the electrode assembly 100, obtaining the second electrical parameter of the electrode assembly 100; the activation method also includes the following steps: before the end of multiple activation cycles, judging whether the second preset condition is met based on the second electrical parameter; if so, determining that the activation is successful, and stopping the execution of the remaining activation cycles in the activation cycle; if not, determining that the activation has failed, and continuing to execute the next activation cycle until the activation process is completed.

[0142] As an embodiment, the activation method further includes the following steps: during the execution of the activation cycle, controlling the display to display a real-time monitoring interface during the execution of the activation cycle.

[0143] As an embodiment, the activation method also includes the following steps: during the execution of the activation cycle, the control display shows a real-time monitoring interface during the execution of the activation cycle, and the real-time monitoring interface includes at least one of the following information: a curve of changes in the potential of the electrode assembly 100 during the execution of the activation cycle; measurement data of the potential of the electrode assembly 100 during the execution of the activation cycle; a curve of changes in the impedance of the electrode assembly 100 during the execution of the activation cycle; measurement data of the impedance of the electrode assembly 100 during the execution of the activation cycle; a curve of changes in the current of the electrode assembly 100 during the execution of the activation cycle; measurement data of the current of the electrode assembly 100 during the execution of the activation cycle; a curve of changes in the power of the electrode assembly 100 during the execution of the activation cycle; measurement data of the power of the electrode assembly 100 during the execution of the activation cycle.

[0144] As an embodiment, the activation method also includes the following steps: after multiple activation cycles are completed, the display is controlled to display an activation result interface, and the activation result interface includes at least one of the following information: a curve of changes in the potential of the electrode assembly 100 during the activation cycle; measurement data of the potential of the electrode assembly 100 during the activation cycle; the standard deviation of the potential of the electrode assembly 100 during the activation cycle or the standard deviation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; the coefficient of variation of the potential of the electrode assembly 100 during the activation cycle or the coefficient of variation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; a curve of changes in the impedance of the electrode assembly 100 during the activation cycle; measurement data of the impedance of the electrode assembly 100 during the activation cycle; a curve of changes in the current of the electrode assembly 100 during the activation cycle; measurement data of the current of the electrode assembly 100 during the activation cycle; a curve of changes in the power of the electrode assembly 100 during the activation cycle; measurement data of the power of the electrode assembly 100 during the activation cycle.

[0145] 1 and 2 , as an embodiment, the process of starting activation of the electrode assembly 100 includes: when the usage time or number of uses of the electrode assembly 100 exceeds a range, or when the electrode assembly 100 fails, starting the replacement process of the electrode assembly 100; inputting the batch number, installation date and expiration date of the electrode assembly 100; entering the activation and confirmation process interface of the electrode assembly 100; preparing a certain volume of serum quality control product, placing it in a fixed position on the table panel or in a sample position on the sample rack, and the electrode assembly 100 starts to automatically perform electrode activation; after the electrode assembly 100 is activated, the diagnostic function of the electrode assembly 100 is automatically executed; the electrode assembly 100 diagnoses and determines whether the performance meets the index requirements. If so, the electrode activation is stopped. If not, an alarm is triggered to remind reactivation.

[0146] 1 and 3 , as an embodiment, the automatic activation process of the electrode assembly 100 is as follows: first, the electrolyte pre-measurement perfusion action is performed, and then the electrolyte pre-measurement preparation is performed, a certain volume of diluent is injected into the detection container 200, and then the first sample distribution device 400 draws the first liquid (here taking the serum quality control product as an example) into the detection container 200, and then the stirring structure inside the detection container 200 stirs and mixes the diluent and the first liquid in the detection container 200 to obtain an activated liquid, and a certain volume of activated liquid is drawn into the measurement channel of the electrode assembly 100, maintained for a certain time, and at fixed intervals, the voltage signal of the electrode assembly 100 is collected, and the measurement voltage Es of the electrode assembly 100 is calculated, and then the activated liquid is discharged to the waste liquid channel 320, and a certain volume of diluent and internal standard solution are injected into the detection container 200 and mixed, and then the mixture of the diluent and internal standard solution is drawn into the measurement channel of the electrode assembly 100, maintained for a certain time, and at fixed intervals, the voltage signal EMF of the electrode assembly 100 is collected, and the measurement voltage Em of the internal standard solution is calculated. After completing one activation cycle, repeat the process and record the Es-Em of each activation cycle. Repeat the above steps for a sufficient number of activation times until the electrode activation is completed.

[0147] As shown in FIG1 and FIG4 , as an embodiment, an activation diagnosis process for the electrode assembly 100 includes calculating the mean of the potential difference of the last 20 activation tests, calculating the standard deviation (SD) and coefficient of variation (CV) of each of the 20 activation tests, and determining whether the CV is within the specification. The calculation formulas for SD and CV% are as follows:

[0148] 1 and 5 , as another embodiment, another activation diagnosis process of the electrode assembly 100 includes: calculating the mean Xave of the ES-EM potential difference of the last 20 activation cycles, calculating the sliding standard deviation SD of the 10 adjacent activation cycles, calculating the sliding coefficient of variation CV of the Na / K / Cl potential of the 10 adjacent activation cycles, and determining whether the CV is within the index.

[0149] This embodiment provides a process for activating the electrode assembly 100 using a serum-based quality control sample to automatically activate the electrode assembly 100. The activation process uses a serum-based quality control sample to ensure effective activation of the electrode assembly 100. Furthermore, by controlling the concentration of the activated serum sample and the time it takes to rinse the electrode assembly 100, the activation process is accelerated, ensuring full activation of the electrode assembly 100. Based on the activation process of the electrode assembly 100, the activation effect of the electrode assembly 100 can be automatically diagnosed by calculating the voltage measured by the quality control sample.

[0150] Example 2:

[0151] The sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment differ from those in the first embodiment mainly in whether an internal standard solution is used in the activation process and the determination. Specifically, in the first embodiment, an internal standard solution is used in both the activation process and the electrolyte determination process; whereas in the present embodiment, no internal standard solution is used in both the activation process and the electrolyte determination process.

[0152] As an implementation mode, in this embodiment, the second electrical parameter is an electric potential; judging whether the first preset condition is met based on the second electrical parameter measured in the second preset number of activation cycles includes: calculating the first electric potential change parameter based on the electric potential of the activated liquid flowing through the electrode assembly 100 measured in the second preset number of activation cycles, and judging whether the first preset condition is met based on the first electric potential change parameter.

[0153] That is, after the activation process is completed, determining whether the second electrical parameter meets the first preset condition includes: calculating the first potential change parameter based on at least the potential corresponding to the second electrical parameter, and determining whether the first potential change parameter meets the first preset condition.

[0154] In one embodiment, the first potential variation parameter is the standard deviation of the potential, and the first preset condition includes the standard deviation SD of the potential being within a first preset range. In this embodiment, during the activation process, the standard deviation SD is calculated using the potential of the activation liquid flowing through the electrode assembly 100.

[0155] In one embodiment, the first potential variation parameter is the coefficient of variation (CV) of the potential, and the first preset condition includes the coefficient of variation (CV) of the potential being within a second preset range. In this embodiment, during the activation process, the coefficient of variation (CV) is calculated using the potential of the activation liquid flowing through the electrode assembly 100.

[0156] Except for the above differences, other parts of the sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0157] Example 3:

[0158] 1 , 3 , and 6 to 8 , the sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment differ from those in the first embodiment primarily in the different basis for determining the end of the activation process. Specifically, in the first embodiment, the activation process ends only after a first preset number of activation cycles have been completed. In the present embodiment, whether to terminate the activation process in advance can be determined before the first preset number of activation cycles have been completed.

[0159] As an implementation mode, in this embodiment, the controller is further configured to: in each activation cycle, control the discharge device 300 to drive the activated liquid in the detection container 200 to flow through the electrode assembly 100, and obtain the second electrical parameter of the electrode assembly 100; determine whether the second preset condition is met based on the second electrical parameter; if so, determine that the activation is successful, and stop executing the remaining activation cycles in the activation process; if not, determine that the activation fails, and continue to execute the next activation cycle until the activation process is completed. In this embodiment, before the activation process proceeds to the first preset number of activation cycles, determine whether the activation is successful. If so, stop continuing the activation. In this way, on the one hand, time can be saved, and on the other hand, the use of reagent consumables (first liquid, diluent, internal standard solution, etc.) can be greatly saved, thereby reducing the user's usage cost.

[0160] As an embodiment, judging whether the second preset condition is met based on the second electrical parameter includes: obtaining a second potential change parameter based on the second electrical parameter in a third consecutive preset number of activation cycles, and judging whether the second preset condition is met based on the second potential change parameter.

[0161] As an embodiment, the sample analyzer 10 further includes an internal standard liquid dispensing device 600 , which is used to dispense the internal standard liquid into the detection container 200 , that is, the internal standard liquid dispensing device 600 is used to dispense the internal standard liquid into the inner cavity of the detection container 200 .

[0162] During a single activation cycle, the controller is further configured to: control the internal standard solution dispensing device 600 to dispense the internal standard solution into the inner cavity of the detection container 200, and control the drainage device 300 to drive the reference solution containing at least the internal standard solution in the detection container 200 to flow sequentially through the drainage port and the electrode assembly 100. While controlling the drainage device 300 to drive the reference solution in the inner cavity of the detection container 200 to flow through the electrode assembly 100, a third electrical parameter of the electrode assembly 100 is obtained, the third electrical parameter being the electric potential.

[0163] Optionally, the calculating of the first potential change parameter based on at least the potential corresponding to the second electrical parameter and the judging of whether the first potential change parameter satisfies the first preset condition include: calculating the first potential change parameter based on the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and judging whether the first potential change parameter satisfies the first preset condition. The first potential change parameter is the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and the first preset condition includes that the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter is within a third preset range; or the first potential change parameter is the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and the first preset condition includes that the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter is within a fourth preset range.

[0164] Optionally, judging whether the second preset condition is satisfied based on the second electrical parameter includes: obtaining a second potential change parameter based on the second electrical parameter in a third consecutive preset number of activation cycles, and judging whether the second preset condition is satisfied based on the second potential change parameter. The second potential change parameter is a potential difference change parameter between the second electrical parameter and the third electrical parameter, and the second preset condition includes one of the following conditions: in the third consecutive preset number of activation cycles, the standard deviation of the potential difference between the second electrical parameter and the third electrical parameter is within a ninth preset range; in the third preset number of activation cycles, the drift of the potential difference between the second electrical parameter and the third electrical parameter is within a tenth preset range; in the third preset number of activation cycles, the deviation of the potential difference between the second electrical parameter and the third electrical parameter relative to the mean is within an eleventh preset range; in the third preset number of activation cycles, the coefficient of variation of the potential difference between the second electrical parameter and the third electrical parameter is within a twelfth preset range.

[0165] In the above scheme, internal standard solution is used when performing the activation process and the electrolyte determination process, and the judgment of whether to terminate the activation process in advance is also based on the potential difference between the activation liquid and the reference solution flowing through the electrode assembly 100. Of course, in specific applications, as an alternative embodiment, internal standard solution can also be used for judgment. In this alternative embodiment, the second preset condition includes one of the following conditions: in three consecutive preset number of activation cycles, the standard deviation of the potential of the electrode assembly 100 is within the fifth preset range; in the third preset number of activation cycles, the drift of the potential of the electrode assembly 100 is within the sixth preset range; in the third preset number of activation cycles, the deviation of the potential of the electrode assembly 100 relative to the mean is within the seventh preset range; in the third preset number of activation cycles, the coefficient of variation of the potential of the electrode assembly 100 is within the eighth preset range.

[0166] As an embodiment, the sample analyzer 10 further includes a display; the controller is further configured to: during the execution of the activation process, control the display to display a real-time monitoring interface of the activation process, wherein the content displayed on the real-time monitoring interface includes at least information on changes in electrical parameters of the electrode assembly 100 during the execution of the activation process, wherein the electrical parameters include at least one of the potential, impedance, current, and power of the electrode assembly 100, and the change information includes a curve of changes in the electrical parameters and at least one of the detected values ​​of the electrical parameters. In this embodiment, by graphically displaying the activation process of the electrode assembly 100 and automatically displaying and judging the activation effect, users and customers can intuitively obtain the activation process and activation effect of the electrode assembly 100.

[0167] As an embodiment, the electrode assembly 100 during the activation process includes at least one of the following information: measurement data of the electric potential of the electrode assembly 100 during the activation process; a curve of changes in the impedance of the electrode assembly 100 during the activation process; measurement data of the impedance of the electrode assembly 100 during the activation process; a curve of changes in the current of the electrode assembly 100 during the activation process; measurement data of the current of the electrode assembly 100 during the activation process; a curve of changes in the power of the electrode assembly 100 during the activation process; and measurement data of the power of the electrode assembly 100 during the activation process.

[0168] As an embodiment, the controller is also configured to: after completing the activation process, control the display to display the activation result interface, and the content displayed on the activation result interface includes the following information: change information of the electrical parameters of the electrode assembly 100 during the execution of the activation process, the electrical parameters include the potential of the electrode assembly 100, the standard deviation of the potential, the standard deviation of the potential difference, the coefficient of variation of the potential, the coefficient of variation of the potential difference, impedance, current and power, at least one of the change information includes the change curve of the electrical parameters and at least one of the detection values ​​of the electrical parameters.

[0169] As an embodiment, the content displayed on the activation result interface includes at least one of the following information: a curve of changes in the potential of the electrode assembly 100 during the execution of the activation process; measured data of the potential of the electrode assembly 100 during the execution of the activation process; the standard deviation of the potential of the electrode assembly 100 during the execution of the activation process or the standard deviation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; the coefficient of variation of the potential of the electrode assembly 100 during the execution of the activation process or the coefficient of variation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; a curve of changes in the impedance of the electrode assembly 100 during the execution of the activation process; measured data of the impedance of the electrode assembly 100 during the execution of the activation process; a curve of changes in the current of the electrode assembly 100 during the execution of the activation process; measured data of the current of the electrode assembly 100 during the execution of the activation process; a curve of changes in the power of the electrode assembly 100 during the execution of the activation process; measured data of the power of the electrode assembly 100 during the execution of the activation process.

[0170] As an embodiment, the activation diagnosis process for the electrode assembly 100 includes: 10 activation cycles as a group, adding a real-time acquisition process of the voltage signal of the electrode assembly 100, and calculating the standard deviation or drift of the EMF, or the deviation of the EMF voltage value from the mean, to determine whether the EMF value of a single test has a jump, thereby determining the number of times the electrode activation is performed. In this solution, the activation process of the electrode assembly 100 can be graphically displayed, and the activation effect can be automatically displayed and judged, allowing the operator to better understand the activation process of the electrode assembly 100.

[0171] As an implementation method, the number of activation cycles included in the activation process can be flexibly set manually.

[0172] Except for the above differences, other parts of the sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment can refer to the first and second embodiments and will not be described in detail here.

[0173] Example 4:

[0174] The sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment differ from those in the first embodiment primarily in the focus of protection. Specifically, the first embodiment focuses on protecting the duration of time the activation liquid flows through the electrode assembly 100 during the automatic activation process, while the present embodiment focuses on protecting the activation medium used in the automatic activation process, i.e., the first liquid.

[0175] Specifically, the sample analyzer 10 provided in this embodiment includes:

[0176] The electrode assembly 100 is used to perform electrolyte measurement on a liquid to be tested, where the liquid to be tested at least includes a sample;

[0177] The detection container 200 has an inner cavity and a liquid discharge port connected to the inner cavity, and the liquid discharge port is used to allow the liquid to be tested to flow from the inner cavity to the electrode assembly 100;

[0178] A first sample dispensing device 400 is used to dispense a sample into the inner cavity of the detection container 200;

[0179] A first liquid dispensing device 700 is used to dispense a first liquid into the inner cavity of the detection container 200;

[0180] a liquid discharge device 300 , the liquid discharge device 300 being connected to the liquid discharge port through the electrode assembly 100 , and being used to discharge the test liquid or the activated liquid in the detection container 200 sequentially through the liquid discharge port and the electrode assembly 100 , wherein the activated liquid includes at least the first liquid;

[0181] A controller configured to execute an activation process to activate the electrode assembly 100 and execute an electrolyte measurement process to measure the sample to obtain an electrolyte measurement result, wherein the activation process includes a plurality of activation cycles and the electrolyte measurement process includes at least one electrolyte measurement cycle;

[0182] During a single activation cycle, the controller is configured to: control the first liquid dispensing device 700 to dispense the first liquid into the detection container 200, and control the liquid discharge device 300 to drive the activated liquid in the detection container 200 to flow through the liquid discharge port and the electrode assembly 100 in sequence;

[0183] During the electrolyte measurement cycle, the controller is configured to: control the first sample dispensing device 400 to dispense the sample into the detection container 200 to form a liquid to be tested; control the liquid discharge device 300 to drive the liquid to be tested in the detection container 200 to flow through the liquid discharge port and the activated electrode assembly 100 in sequence; and obtain the electrolyte measurement result of the sample based on the first electrical parameter of the electrode assembly 100 when the liquid to be tested flows through the electrode assembly 100;

[0184] The first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample, and a salt solution containing protein.

[0185] As an embodiment, the sample analyzer 10 further includes a diluent dispensing device 500, which is used to dispense diluent into the detection container 200; the test liquid is prepared by diluting the sample with the diluent at a first dilution ratio; the activation liquid is prepared by diluting the first liquid with a second dilution ratio; and the second dilution ratio is smaller than the first dilution ratio.

[0186] As an embodiment, the controller is further configured to: obtain a second electrical parameter of the electrode assembly 100 during the process of controlling the discharge device 300 to drive the activated liquid in the detection container 200 to flow through the electrode assembly 100; after the activation process is completed, determine whether the first preset condition is met based on the second electrical parameter; if yes, determine that the activation is successful; if not, determine that the activation has failed, that is, determine that the activation of the electrode assembly 100 has failed.

[0187] As an embodiment, the activation process includes a first preset number of activation cycles; after the activation process is completed, judging whether the first preset condition is met based on the second electrical parameter, including: after completing the first preset number of activation cycles, judging whether the first preset condition is met based on the second electrical parameter measured during the second preset number of activation cycles; wherein the second preset number is less than or equal to the first preset number.

[0188] As an embodiment, the second preset number is less than the first preset number; judging whether the first preset condition is met based on the second electrical parameter measured in the second preset number of activation cycles includes: judging whether the first preset condition is met based on the second electrical parameter measured in the second to last preset number of activation cycles in the activation process.

[0189] As an embodiment, the controller is further configured to: in each activation cycle, control the liquid discharge device 300 to drive the activation liquid in the detection container 200 to flow through the electrode assembly 100, and obtain a second electrical parameter of the electrode assembly 100; determine whether a second preset condition is met based on the second electrical parameter; if so, determine that the activation is successful, and stop executing the remaining activation cycles in the activation process; if not, determine that the activation fails, that is, determine that the activation of the electrode assembly 100 fails, and continue to execute the next activation cycle.

[0190] The activation method for the electrode assembly 100 in the sample analyzer 10 provided in this embodiment includes multiple activation cycles. A single activation cycle includes the following steps: controlling the first liquid dispensing device 700 to dispense a first liquid into the detection container 200, and controlling the liquid discharge device 300 to drive the activated liquid containing at least the first liquid in the detection container 200 to flow through the liquid discharge port of the detection container 200 and the electrode assembly 100 in sequence to be discharged; wherein the first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample, and a saline solution, and the saline solution contains at least protein.

[0191] The rest of the sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment can be referred to in the first to third embodiments and will not be described in detail here.

[0192] Embodiment 5:

[0193] The sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment differ from those in the first embodiment primarily in the focus of protection. Specifically, the first embodiment focuses on protecting the duration of time that the activation liquid flows through the electrode assembly 100 during the automatic activation process, while this embodiment focuses on protecting the graphical display of the execution process of the automatic activation process.

[0194] The sample analyzer 10 provided in this embodiment includes an electrode assembly 100 , a detection container 200 , a first liquid dispensing device 700 , a liquid discharge device 300 , a display, and a controller.

[0195] The electrode assembly 100 is used to perform electrolyte measurement on a liquid to be tested, where the liquid to be tested at least contains a sample. In addition, the electrode assembly 100 can be activated by an activation liquid, where the activation liquid is formed of at least a first liquid.

[0196] The detection container 200 has an inner cavity and a liquid discharge port communicating with the inner cavity. The liquid discharge port is used to allow the liquid to be tested to flow from the inner cavity to the electrode assembly 100 .

[0197] The first liquid dispensing device 700 is used to dispense a first liquid into the inner cavity of the detection container 200 to activate the electrode assembly 100 . Furthermore, the first liquid dispensing device 700 is also used to dispense a sample into the inner cavity of the detection container 200 .

[0198] It can be understood that dispensing the sample and the first liquid into the detection container 200 can be performed by the same dispensing device or by different dispensing devices.

[0199] Optionally, the first liquid dispensing device 700 includes a first sub-liquid dispensing device 701 and a second sub-liquid dispensing device 702, wherein the first sub-liquid dispensing device 701 is used to dispense the sample into the inner cavity of the detection container 200, and the second sub-liquid dispensing device 702 is used to dispense the first liquid into the inner cavity of the detection container 200.

[0200] In other words, the first sub-liquid dispensing device 701 is primarily used to achieve quantitative sample distribution. For example, the first sub-liquid dispensing device 701 injects the sample into the detection container 200 through a dispensing method. The second sub-liquid dispensing device 702 is used to distribute the first liquid into the inner cavity of the detection container 200. The first liquid is used to activate the electrode assembly 100.

[0201] a liquid discharge device 300 , the liquid discharge device 300 being connected to the liquid discharge port through the electrode assembly 100 , and being used to discharge the test liquid or the activated liquid in the detection container 200 sequentially through the liquid discharge port and the electrode assembly 100 , wherein the activated liquid includes at least the first liquid;

[0202] The display is used to display at least the electrolyte measurement result of the sample.

[0203] The controller is configured to execute an activation process to activate the electrode assembly 100, and execute an electrolyte measurement process to measure the sample to obtain an electrolyte measurement result, wherein the activation process includes a plurality of activation cycles, and the electrolyte measurement process includes at least one electrolyte measurement cycle;

[0204] During a single activation cycle, the controller is configured to: control the first liquid dispensing device 700 to dispense the first liquid into the detection container 200, and control the liquid discharge device 300 to drive the activated liquid in the detection container 200 to flow through the liquid discharge port and the electrode assembly 100 in sequence;

[0205] During the electrolyte measurement cycle, the controller is configured to: control the sample dispensing device to dispense the sample into the detection container 200 to form a liquid to be tested, control the liquid discharge device 300 to drive the liquid to be tested in the detection container 200 to flow through the liquid discharge port and the activated electrode assembly 100 in sequence, and obtain the electrolyte measurement result of the sample based on the first electrical parameter of the electrode assembly 100 when the liquid to be tested flows through the electrode assembly 100;

[0206] The controller is further configured to: during the execution of the activation process, control the display to display a real-time monitoring interface of the execution of the activation process.

[0207] As an embodiment, the content displayed on the real-time monitoring interface includes at least the following information: information on changes in electrical parameters of the electrode assembly 100 during the execution of the activation process, the electrical parameters including at least one of the potential, impedance, current and power of the electrode assembly 100, and the change information including the change curve of the electrical parameters and at least one of the detection values ​​of the electrical parameters.

[0208] As an embodiment, the content displayed on the real-time monitoring interface includes at least one of the following information: a curve of changes in the potential of the electrode assembly 100 during the execution of the activation process; measurement data of the potential of the electrode assembly 100 during the execution of the activation process; a curve of changes in the impedance of the electrode assembly 100 during the execution of the activation process; measurement data of the impedance of the electrode assembly 100 during the execution of the activation process; a curve of changes in the current of the electrode assembly 100 during the execution of the activation process; measurement data of the current of the electrode assembly 100 during the execution of the activation process; a curve of changes in the power of the electrode assembly 100 during the execution of the activation process; measurement data of the power of the electrode assembly 100 during the execution of the activation process.

[0209] 1 , 7 and 8 , as an embodiment, the real-time monitoring interface includes at least one of the following information: a curve showing a change in the potential of the electrode assembly 100 during the activation process.

[0210] As an embodiment, the controller is also configured to: after completing the activation process, control the display to display the activation result interface, the activation result interface contains the following information: the change information of the electrical parameters of the electrode assembly 100 during the execution of the activation process, the electrical parameters include the potential of the electrode assembly 100, the standard deviation of the potential, the standard deviation of the potential difference, the coefficient of variation of the potential, the coefficient of variation of the potential difference, impedance, current and power, at least one of the change information includes the change curve of the electrical parameters and at least one of the detection values ​​of the electrical parameters.

[0211] As an embodiment, the activation result interface includes the following information: a curve of changes in the potential of the electrode assembly 100 during the execution of the activation process; measurement data of the potential of the electrode assembly 100 during the execution of the activation process; the standard deviation of the potential of the electrode assembly 100 during the execution of the activation process or the standard deviation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; the coefficient of variation of the potential of the electrode assembly 100 during the execution of the activation process or the coefficient of variation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; a curve of changes in the impedance of the electrode assembly 100 during the execution of the activation process; measurement data of the impedance of the electrode assembly 100 during the execution of the activation process; a curve of changes in the current of the electrode assembly 100 during the execution of the activation process; measurement data of the current of the electrode assembly 100 during the execution of the activation process; a curve of changes in the power of the electrode assembly 100 during the execution of the activation process; measurement data of the power of the electrode assembly 100 during the execution of the activation process.

[0212] As an embodiment, the controller is further configured to: in each activation cycle, control the discharge device 300 to drive the activation liquid in the detection container 200 to flow through the electrode assembly 100, and obtain the second electrical parameter of the electrode assembly 100; based on the second electrical parameter, determine whether the second preset condition is met; if so, determine that the activation is successful, and stop executing the remaining activation cycles in the activation process; if not, determine that the activation has failed, and continue to execute the next activation cycle.

[0213] As an embodiment, the sample analyzer 10 further includes a diluent dispensing device 500, which is used to dispense a diluent into the detection container 200. The test liquid is prepared by diluting the sample with the diluent at a first dilution ratio; the activation liquid is prepared by diluting the first liquid with the diluent at a second dilution ratio, where the second dilution ratio is smaller than the first dilution ratio.

[0214] As an embodiment, the first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample and a saline solution, and the saline solution contains at least protein.

[0215] The activation method for the electrode assembly 100 in the sample analyzer 10 provided in this embodiment includes multiple activation cycles. A single activation cycle includes the following steps: controlling the first liquid dispensing device 700 to dispense the first liquid into the detection container 200, controlling the liquid discharge device 300 to drive the activation liquid containing at least the first liquid in the detection container 200 to flow through the liquid discharge port of the detection container 200 and the electrode assembly 100 in sequence to be discharged; during the execution of the activation cycle, controlling the display to display a real-time monitoring interface during the execution of the activation cycle.

[0216] As an embodiment, the real-time monitoring interface includes at least one of the following information: a curve of changes in the potential of the electrode assembly 100 during the activation cycle; measurement data of the potential of the electrode assembly 100 during the activation cycle; a curve of changes in the impedance of the electrode assembly 100 during the activation cycle; measurement data of the impedance of the electrode assembly 100 during the activation cycle; a curve of changes in the current of the electrode assembly 100 during the activation cycle; measurement data of the current of the electrode assembly 100 during the activation cycle; a curve of changes in the power of the electrode assembly 100 during the activation cycle; measurement data of the power of the electrode assembly 100 during the activation cycle.

[0217] As an embodiment, the activation method also includes the following steps: after multiple activation cycles are completed, the display is controlled to display an activation result interface, and the activation result interface includes at least one of the following information: a curve of changes in the potential of the electrode assembly 100 during the activation cycle; measurement data of the potential of the electrode assembly 100 during the activation cycle; the standard deviation of the potential of the electrode assembly 100 during the activation cycle or the standard deviation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; the coefficient of variation of the potential of the electrode assembly 100 during the activation cycle or the coefficient of variation of the potential difference between the activation liquid flowing through the electrode assembly 100 and the internal standard liquid flowing through the electrode assembly 100; a curve of changes in the impedance of the electrode assembly 100 during the activation cycle; measurement data of the impedance of the electrode assembly 100 during the activation cycle; a curve of changes in the current of the electrode assembly 100 during the activation cycle; measurement data of the current of the electrode assembly 100 during the activation cycle; a curve of changes in the power of the electrode assembly 100 during the activation cycle; measurement data of the power of the electrode assembly 100 during the activation cycle.

[0218] The rest of the sample analyzer 10 and the activation method of the electrode assembly 100 in the sample analyzer 10 provided in this embodiment can be referred to in Embodiments 1 to 4 and will not be described in detail here.

[0219] The above are only preferred embodiments of the present application and do not limit the patent scope of the present application. All equivalent structural transformations made using the contents of the present application description and drawings under the inventive concept of the present application, or direct / indirect application in other related technical fields are included in the patent protection scope of the present application.

Claims

1. A sample analyzer, characterized in that: include: An electrode assembly, the electrode assembly is used to perform electrolyte measurement on a liquid to be tested and to activate the electrode assembly using an activation liquid, the liquid to be tested at least contains a sample, and the activation liquid is formed by at least a first liquid; A detection container, the detection container having an inner cavity for containing liquid and a liquid discharge port communicated with the inner cavity, the liquid discharge port being used for allowing the liquid contained in the inner cavity to flow from the inner cavity to the electrode assembly; a first liquid dispensing device, the first liquid dispensing device being used to dispense the sample and the first liquid into the inner cavity of the detection container; a liquid discharge device, the liquid discharge device being in communication with the electrode assembly and being used for discharging liquid flowing through the electrode assembly; A controller, the controller being configured to execute an electrolyte determination process to perform an electrolyte determination on the liquid to be tested to obtain an electrolyte determination result of the sample, and execute an activation process to activate the electrode assembly, the electrolyte determination process comprising at least one electrolyte determination cycle, and the activation process comprising a plurality of activation cycles; In a single electrolyte determination cycle, the controller is configured to: control the first liquid dispensing device to dispense the sample into the inner cavity of the detection container to form the liquid to be tested, control the liquid discharge device to drive the liquid to be tested in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence, and obtain the electrolyte determination result of the sample at least according to the first electrical parameter of the electrode assembly when the liquid to be tested flows through the electrode assembly; In a single activation cycle, the controller is configured to: control the first liquid dispensing device to dispense the first liquid into the inner cavity of the detection container to form the activated liquid, and control the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence to be discharged; Wherein, the time length of the activated liquid flowing through the electrode assembly in a single activation cycle is longer than the time length of the test liquid flowing through the electrode assembly in a single electrolyte determination cycle; and / or, the first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample, and a salt solution containing protein.

2. The sample analyzer according to claim 1, wherein: The first liquid dispensing device includes a first sub-liquid dispensing device and a second sub-liquid dispensing device, wherein the first sub-liquid dispensing device is used to dispense the sample into the inner cavity of the detection container, and the second sub-liquid dispensing device is used to dispense the first liquid into the inner cavity of the detection container.

3. The sample analyzer according to claim 1, wherein: The controller is further configured to: in a single activation cycle, control the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the electrode assembly at a first speed, and in a single electrolyte determination cycle, control the liquid discharge device to drive the liquid to be tested in the inner cavity of the detection container to flow through the electrode assembly at a second speed, wherein the first speed is less than the second speed; or The controller is also configured to: within a single activation cycle, control the drainage device to drive the activated liquid in the inner cavity of the detection container to flow through the electrode assembly in an intermittent driving manner; within a single electrolyte measurement cycle, control the drainage device to drive the liquid to be tested in the inner cavity of the detection container to flow through the electrode assembly in a continuous driving manner.

4. The sample analyzer according to claim 1, characterized in that: The sample analyzer further comprises a diluent dispensing device, the diluent dispensing device being used to dispense the diluent into the inner cavity of the detection container; The liquid to be tested is prepared by diluting the sample with the diluent; The activated liquid is prepared by diluting the first liquid with the diluent.

5. The sample analyzer according to claim 4, characterized in that: The liquid to be tested is prepared by diluting the sample with the diluent at a first dilution ratio; The activated liquid is prepared by diluting the first liquid with the diluent at a second dilution ratio; The second dilution ratio is smaller than the first dilution ratio.

6. The sample analyzer according to any one of claims 1 to 5, characterized in that: The controller is also configured to: In the process of controlling the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the electrode assembly in at least one activation cycle, obtaining a second electrical parameter of the electrode assembly; After the activation process is completed, determining whether the second electrical parameter meets a first preset condition; If yes, it is determined that the electrode assembly is activated successfully; If not, it is determined that activation of the electrode assembly has failed.

7. The sample analyzer according to claim 6, wherein: The number of the plurality of activation cycles is a first preset number, the number of the at least one activation cycle is a second preset number, and the second preset number is smaller than the first preset number.

8. The sample analyzer according to claim 7, wherein: The last consecutive activation cycles in the activation process are used as the second preset number of activation cycles.

9. The sample analyzer according to any one of claims 6 to 8, characterized in that: The second electrical parameter is electric potential; After the activation process is completed, judging whether the second electrical parameter meets the first preset condition includes: calculating the first potential change parameter at least according to the potential corresponding to the second electrical parameter, and judging whether the first potential change parameter meets the first preset condition.

10. The sample analyzer according to claim 9, characterized in that: The first potential variation parameter includes the standard deviation of the potential, and the first preset condition includes that the standard deviation of the potential is within a preset range; or, The first potential variation parameter includes a coefficient of variation of the potential, and the first preset condition includes that the coefficient of variation of the potential is within a second preset range.

11. The sample analyzer according to claim 9, wherein: The sample analyzer also includes an internal standard liquid dispensing device, which is used to distribute the internal standard liquid into the inner cavity of the detection container; In a single activation cycle, the controller is further configured to: control the internal standard liquid dispensing device to dispense the internal standard liquid into the inner cavity of the detection container, and control the liquid discharge device to drive the reference liquid containing at least the internal standard liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence; In the process of controlling the liquid discharge device to drive the reference liquid in the inner cavity of the detection container to flow through the electrode assembly, obtaining a third electrical parameter of the electrode assembly, wherein the third electrical parameter is an electrical potential; The calculating of the first potential change parameter at least according to the potential corresponding to the second electrical parameter, and judging whether the first potential change parameter satisfies the first preset condition, comprises: calculating the first potential change parameter according to the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and judging whether the first potential change parameter satisfies the first preset condition; wherein the first potential change parameter is the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and the first preset condition comprises that the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter is within a third preset range; or, the first potential change parameter is the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, and the first preset condition comprises that the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter is within a fourth preset range; In a single electrolyte determination cycle, the controller is further configured to: control the internal standard liquid dispensing device to dispense the internal standard liquid into the inner cavity of the detection container, control the liquid discharge device to drive the reference liquid in the inner cavity of the detection container containing at least the internal standard liquid to flow through the liquid discharge port and the electrode assembly in sequence, and obtain a fourth electrical parameter of the electrode assembly in the process of controlling the liquid discharge device to drive the reference liquid in the inner cavity of the detection container to flow through the electrode assembly; The obtaining of the electrolyte determination result of the sample at least based on the first electrical parameter of the electrode assembly when the liquid to be tested flows through the electrode assembly includes: obtaining the electrolyte determination result of the sample based on the difference between the first electrical parameter and the fourth electrical parameter.

12. The sample analyzer according to any one of claims 1 to 4, characterized in that: The controller is also configured to: In each activation cycle, the second electrical parameter of the electrode assembly is obtained during the process of controlling the liquid discharge device to drive the activation liquid in the inner cavity of the detection container to flow through the electrode assembly; For each of the activation cycles, determining whether the second electrical parameter meets a second preset condition; If yes, it is determined that the activation of the electrode assembly is successful, and the remaining activation cycles in the activation process are stopped; If not, continue to execute the next activation cycle until the activation process is completed.

13. The sample analyzer according to claim 12, wherein: The determining whether the second electrical parameter satisfies the second preset condition comprises: calculating a second potential change parameter based on at least the second electrical parameter obtained in a third preset number of consecutive activation cycles including the current activation cycle, and determining whether the second potential change parameter satisfies the second preset condition, wherein the second electrical parameter is a potential; Among them, the second preset condition includes that the second potential change parameter is within a fifth preset range, and the second potential change parameter includes any one of the following: the standard deviation of the potential corresponding to the second electrical parameter, the drift of the potential corresponding to the second electrical parameter, the deviation of the potential corresponding to the second electrical parameter relative to the mean, and the coefficient of variation of the potential corresponding to the second electrical parameter.

14. The sample analyzer according to claim 12, wherein: The sample analyzer also includes an internal standard liquid dispensing device, which is used to distribute the internal standard liquid into the inner cavity of the detection container; In a single activation cycle, the controller is further configured to: control the internal standard liquid dispensing device to dispense the internal standard liquid into the inner cavity of the detection container, and control the liquid discharge device to drive the reference liquid containing at least the internal standard liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence; In the process of controlling the liquid discharge device to drive the reference liquid in the inner cavity of the detection container to flow through the electrode assembly, obtaining a third electrical parameter of the electrode assembly, wherein the third electrical parameter is an electrical potential; The step of calculating the second potential change parameter based on at least the second electrical parameter obtained in the third consecutive preset number of activation cycles including the current activation cycle, and judging whether the second potential change parameter satisfies the second preset condition comprises: calculating the second potential change parameter based on the second electrical parameter and the third electrical parameter obtained in the third consecutive preset number of activation cycles including the current activation cycle, and judging whether the second potential change parameter satisfies the second preset condition; wherein, The second potential change parameter is a potential difference change parameter between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter. The second preset condition includes that the potential difference change parameter is within a sixth preset range. The potential difference change parameter includes any one of the following: the standard deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, the drift of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter, the deviation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter relative to the mean, and the coefficient of variation of the potential difference between the potential corresponding to the second electrical parameter and the potential corresponding to the third electrical parameter.

15. The sample analyzer according to claim 14, characterized in that: The sample analyzer also includes a display; The controller is also configured to: during the execution of the activation process, control the display to display a real-time monitoring interface of the activation process, wherein the real-time monitoring interface is at least used to display change information of electrical parameters of the electrode assembly during the execution of the activation process, wherein the electrical parameters include at least one of the potential, impedance, current and power of the electrode assembly, and the change information includes a change curve of the electrical parameters and at least one of the detected values ​​of the electrical parameters.

16. The sample analyzer according to claim 15, characterized in that: The controller is also configured to: after completing the activation process, control the display to display an activation result interface, and the activation result interface is at least used to display the change information of the electrical parameters of the electrode assembly during the execution of the activation process, the electrical parameters include the potential of the electrode assembly, the standard deviation of the potential, the standard deviation of the potential difference, the coefficient of variation of the potential, the coefficient of variation of the potential difference, impedance, current and at least one of the power, and the change information includes the change curve of the electrical parameter and at least one of the detected values ​​of the electrical parameter.

17. The sample analyzer according to any one of claims 1 to 4, characterized in that: The sample analyzer is pre-stored with at least one of the following third preset conditions: the sample analyzer is installed and started for a first preset time; the electrode assembly is replaced and the sample analyzer is installed and started for a second preset time; A third preset time has passed since the last activation process was performed; and a fourth preset time has passed since the electrode assembly did not perform electrolyte measurement. Arriving at a preset time point of a preset activation cycle; obtaining information requiring activation of the electrode assembly according to instructions input by an operator through a human-computer interaction device; The controller is further configured to execute the activation process when the third preset condition is met.

18. The sample analyzer according to any one of claims 1 to 4, characterized in that: The sample analyzer further comprises a reagent dispensing device, a sample dispensing device and at least one optical measuring device, wherein the sample dispensing device is used to draw a sample from a sample container and distribute it to a reaction container, the reagent dispensing device is used to draw a reagent from a reagent container and distribute it to a reaction container, and the at least one optical measuring device is used to perform optical measurement on a reaction solution made of at least the sample and the reagent; The at least one optical measuring device comprises at least one of a first optical measuring component, a second optical measuring component, and a third optical measuring component, wherein the first optical measuring component is used to measure immune-related parameters of the reaction solution, the second optical measuring component is used to measure biochemical-related parameters of the reaction solution, and the third optical measuring component is used to measure coagulation-related parameters of the reaction solution; Wherein, the sample dispensing device and the first liquid dispensing device are the same device or two independent devices.

19. A sample analyzer, characterized in that: include: An electrode assembly, the electrode assembly is used to perform electrolyte determination on a liquid to be tested and to activate the electrode assembly using an activation liquid, the liquid to be tested at least contains a sample, and the activation liquid is formed by at least a first liquid; A detection container, the detection container having an inner cavity for containing liquid and a liquid discharge port communicated with the inner cavity, the liquid discharge port being used for allowing the liquid contained in the inner cavity to flow from the inner cavity to the electrode assembly; a first liquid dispensing device, the first liquid dispensing device being used to dispense the sample and the first liquid into the inner cavity of the detection container; a liquid discharge device, the liquid discharge device being in communication with the electrode assembly and used for discharging liquid flowing through the electrode assembly; A controller, the controller being configured to execute an electrolyte determination process to perform an electrolyte determination on the liquid to be tested to obtain an electrolyte determination result of the sample, and execute an activation process to activate the electrode assembly, the electrolyte determination process comprising at least one electrolyte determination cycle, and the activation process comprising a plurality of activation cycles; In a single electrolyte determination cycle, the controller is configured to: control the first liquid dispensing device to dispense the sample into the inner cavity of the detection container to form the liquid to be tested, control the liquid discharge device to drive the liquid to be tested in the inner cavity of the detection container to flow through the liquid discharge port and the activated electrode assembly in sequence, and obtain the electrolyte determination result of the sample at least according to the first electrical parameter of the electrode assembly when the liquid to be tested flows through the electrode assembly; In a single activation cycle, the controller is configured to: control the first liquid dispensing device to dispense the first liquid into the inner cavity of the detection container to form the activated liquid, and control the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence to be discharged; Wherein, whether the electrode assembly is successfully activated is determined based on a second electrical parameter of the electrode assembly detected in at least two activation cycles in the plurality of activation cycles, wherein the second electrical parameter is detected by the row The detection is obtained during the process in which the activation liquid in the inner cavity of the detection container is driven by a liquid device to flow through the electrode assembly.

20. The sample analyzer according to claim 19, wherein: The plurality of activation cycles are continuous, or the time interval between each activation cycle and an adjacent activation cycle is the same.

21. The sample analyzer according to claim 19, wherein: The controller is also configured to: At the end of activation, determining whether the electrode assembly is successfully activated based on a second electrical parameter of the electrode assembly detected in at least two activation cycles within the plurality of activation cycles; Alternatively, in each activation cycle, the second electrical parameter of the electrode assembly is obtained during the process of controlling the discharge device to drive the activation liquid in the inner cavity of the detection container to flow through the electrode assembly; for each activation cycle, it is determined whether the second electrical parameter meets a second preset condition; if so, it is determined that the activation of the electrode assembly is successful, and the remaining activation cycles in the activation process are stopped; if not, the next activation cycle is continued until the activation process is completed.

22. A sample analyzer, characterized in that: include: An electrode assembly, the electrode assembly being used to perform electrolyte measurement on a liquid to be tested, the liquid to be tested at least comprising a sample; A detection container, the detection container having an inner cavity for containing liquid and a liquid discharge port communicated with the inner cavity, the liquid discharge port being used for allowing the liquid contained in the inner cavity to flow from the inner cavity to the electrode assembly; a first liquid dispensing device, the first liquid dispensing device being used to dispense the sample and the first liquid into the inner cavity of the detection container; a liquid discharge device, the liquid discharge device being in communication with the electrode assembly and being used for discharging liquid flowing through the electrode assembly; A display, the display being used to display at least the electrolyte measurement result of the sample; A controller, the controller being configured to execute an electrolyte determination process to perform an electrolyte determination on the liquid to be tested to obtain an electrolyte determination result of the sample, and execute an activation process to activate the electrode assembly, the electrolyte determination process comprising at least one electrolyte determination cycle, and the activation process comprising a plurality of activation cycles; In a single electrolyte determination cycle, the controller is configured to: control the first liquid dispensing device to dispense the sample into the inner cavity of the detection container to form the liquid to be tested, control the liquid discharge device to drive the liquid to be tested in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence, and control the electrode assembly to discharge the sample into the inner cavity of the detection container according to the first liquid discharge port and the electrode assembly at least according to the second liquid discharge port and the electrode assembly when the liquid to be tested flows through the electrode assembly. An electrical parameter obtains the electrolyte measurement result of the sample; In a single activation cycle, the controller is configured to: control the first liquid dispensing device to dispense the first liquid into the inner cavity of the detection container to form the activated liquid, and control the liquid discharge device to drive the activated liquid in the inner cavity of the detection container to flow through the liquid discharge port and the electrode assembly in sequence to be discharged; The controller is further configured to: during the execution of the activation process, control the display to display a real-time monitoring interface during the execution of the activation process.

23. The sample analyzer according to claim 22, wherein: The real-time monitoring interface is at least used to display the change information of the electrical parameters of the electrode assembly during the execution of the activation process, the electrical parameters include at least one of the potential, impedance, current and power of the electrode assembly, and the change information includes at least one of the change curve of the electrical parameters and the detection value of the electrical parameters; and / or, The controller is also configured to: after completing the activation process, control the display to display an activation result interface, and the activation result interface is at least used to display the change information of the electrical parameters of the electrode assembly during the execution of the activation process, the electrical parameters include the potential of the electrode assembly, the standard deviation of the potential, the standard deviation of the potential difference, the coefficient of variation of the potential, the coefficient of variation of the potential difference, impedance, current and at least one of the power, and the change information includes the change curve of the electrical parameter and at least one of the detected values ​​of the electrical parameter.

24. A method for activating an electrode assembly in a sample analyzer, characterized in that: The method comprises a plurality of activation cycles, wherein a single activation cycle comprises the following steps: controlling a first liquid dispensing device to dispense a first liquid into a detection container, and controlling a liquid discharge device to drive an activation liquid containing at least the first liquid in the detection container to flow through a liquid discharge port of the detection container and an electrode assembly in sequence to be discharged; Wherein, the duration of the activation liquid flowing through the electrode assembly in a single activation cycle is longer than the duration of the test liquid containing at least the sample flowing through the electrode assembly in a single electrolyte determination cycle; And / or, the first liquid is one of a serum quality control product, a plasma quality control product, a serum sample, a plasma sample and a saline solution, and the saline solution contains at least protein; and / or, during the execution of the activation cycle, controlling the display to display a real-time monitoring interface during the execution of the activation cycle; And / or, determining whether the electrode assembly is successfully activated based on a second electrical parameter of the electrode assembly detected in at least two activation cycles among the multiple activation cycles, wherein the second electrical parameter is detected during the process in which the activation liquid in the inner cavity of the detection container is driven by the liquid discharge device to flow through the electrode assembly.

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