Blood glucose measuring method, and device and medium

Abstract

The present application provides a tympanic membrane temperature measuring apparatus, a blood glucose measuring method, a system, and a device. First, a target tympanic membrane temperature is acquired; a target oral cavity temperature is estimated on the basis of a pre-established temperature correspondence between the tympanic membrane and the oral cavity; a temperature correspondence between blood glucose increments and oral cavity temperature increments is then established on the basis of a pre-calibrated invasive blood glucose value and an oral cavity calibration temperature, so as to calculate a target blood glucose increment; and finally, a target blood glucose value is calculated on the basis of the target blood glucose increment and the pre-calibrated invasive blood glucose value. In this way, impact of other factors on blood glucose measurement is reduced while increasing the apparent temperature in the blood glucose measurement process.

Description

Blood glucose measurement method, device and medium Technical Field

[0001] The present application relates to the field of blood glucose monitoring, and in particular to a blood glucose measurement method, device and medium. Background Art

[0002] In recent years, with the continuous development of science and technology, blood glucose monitoring technology has gradually been upgraded from invasive blood glucose monitoring technology to non-invasive blood glucose monitoring technology to meet people's needs for blood glucose monitoring in daily life.

[0003] Among the existing technologies, most non-invasive blood glucose monitoring technologies monitor blood glucose levels by measuring the temperature of the finger skin or the temperature of the mouth. However, measuring blood glucose levels by measuring the temperature of the finger skin is often easily affected by the external temperature environment and leads to inaccurate measurements. Measuring blood glucose levels by measuring the temperature of the mouth makes the monitoring process cumbersome and requires frequent opening of the mouth to measure the oral temperature, which makes the monitoring sensation not user-friendly.

[0004] Summary of the Invention

[0005] The main purpose of the embodiments of the present application is to propose a blood glucose measurement method, device and medium that can improve the physical sensitivity of the blood glucose measurement process while reducing the impact of other factors on blood glucose measurement.

[0006] To achieve the above objectives, a first aspect of an embodiment of the present application provides a blood glucose measurement method, comprising the following steps:

[0007] Obtaining target tympanic membrane temperature and target ambient temperature;

[0008] According to the relationship between the ambient temperature and the temperature difference between the eardrum and the oral cavity, the target ambient temperature is converted.

[0009] Obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature;

[0010] According to the temperature difference, the target tympanic membrane temperature is converted to obtain the target oral temperature;

[0011] According to the relationship between oral temperature and blood sugar, the target oral temperature is converted to the corresponding blood sugar value to obtain the target blood sugar value.

[0012] Furthermore, in some embodiments, the target ambient temperature is converted based on the relationship between the ambient temperature and the temperature difference between the eardrum and the oral cavity to obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature, further comprising the following steps:

[0013] Obtain multiple environmental calibration temperatures and their corresponding tympanic membrane calibration temperatures and oral cavity calibration temperatures;

[0014] Calculating the difference between the tympanic membrane calibration temperature and the oral cavity calibration temperature at each environmental calibration temperature according to the environmental calibration temperature, and obtaining the temperature difference between the tympanic membrane and the oral cavity at multiple environmental calibration temperatures;

[0015] Determining a target temperature difference relationship between the eardrum and the oral cavity at different ambient temperatures based on a plurality of ambient calibration temperatures and their corresponding temperature differences;

[0016] According to the target temperature difference relationship, the target ambient temperature is converted to obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature.

[0017] Furthermore, in some embodiments, determining a target temperature difference relationship between the eardrum and the oral cavity at different ambient temperatures based on a plurality of ambient calibration temperatures and their corresponding temperature differences further includes the following steps:

[0018] Obtaining a universal temperature difference relationship between the eardrum and the oral cavity as a first temperature difference relationship;

[0019] Determining, based on the plurality of ambient calibration temperatures and the corresponding temperature differences, a temperature difference relationship between the eardrum and the oral cavity at different ambient temperatures as a second temperature difference relationship;

[0020] Under the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain a target temperature difference relationship.

[0021] Furthermore, in some embodiments, at the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain a target temperature difference relationship, further comprising the following steps:

[0022] If the absolute value of the relationship difference is less than a preset threshold, the second temperature difference relationship is used as the target temperature difference relationship;

[0023] Alternatively, if the absolute value of the relationship difference is greater than or equal to the preset threshold, the relationship curve of the first temperature difference relationship is shifted up and down in the corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship.

[0024] Furthermore, in some embodiments, if the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is shifted up and down in a corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship, and the following steps are also included:

[0025] When the relationship difference is a positive number, the relationship curve of the first temperature difference relationship is shifted downward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship;

[0026] Alternatively, when the relationship difference is a negative number, the relationship curve of the first temperature difference relationship is shifted upward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship.

[0027] Furthermore, in some embodiments, obtaining a universal temperature difference relationship between the eardrum and the oral cavity as the first temperature difference relationship further includes the following steps:

[0028] Obtain multiple ambient universal temperatures, and the corresponding tympanic membrane universal temperatures and oral universal temperatures under the multiple ambient universal temperatures;

[0029] Calculating the difference between the universal temperature of the tympanic membrane and the universal temperature of the oral cavity at each universal temperature according to the ambient universal temperature, and obtaining a first universal temperature difference between the tympanic membrane and the oral cavity at multiple universal temperatures;

[0030] Performing data dimension reduction on the first universal temperature difference under different environmental universal temperatures to obtain the second universal temperature difference under different environmental universal temperatures;

[0031] According to a plurality of ambient universal temperatures and their corresponding second universal temperature differences, a universal temperature difference relationship between the eardrum and the oral cavity at different universal ambient temperatures is determined and used as a first temperature difference relationship.

[0032] Furthermore, in some embodiments, based on the relationship between oral temperature and blood glucose, the target oral temperature is converted to a corresponding blood glucose value to obtain the target blood glucose value, further comprising the following steps:

[0033] Obtaining the calibrated blood glucose value and oral calibration temperature before measuring the oral temperature, wherein the calibrated blood glucose value is calibrated in an invasive manner;

[0034] Obtaining a target oral temperature increment according to the target oral temperature and the oral calibration temperature;

[0035] According to the relationship between the oral temperature increment and the blood glucose increment, the target oral temperature increment is converted to obtain the target blood glucose increment;

[0036] The target blood glucose value is obtained based on the calibrated blood glucose value and the target blood glucose increment.

[0037] Furthermore, in some embodiments, the target oral temperature increment is converted based on the relationship between the oral temperature increment and the blood glucose increment to obtain the target blood glucose increment, further comprising the following steps:

[0038] Obtain multiple oral calibration temperatures and multiple calibration blood glucose values;

[0039] According to the multiple oral calibration temperatures, the differences between the oral calibration temperatures at adjacent times are calculated in sequence to obtain multiple oral calibration temperature increments;

[0040] Based on the multiple calibrated blood glucose values, the differences between the calibrated blood glucose values ​​at adjacent times are calculated in sequence to obtain multiple calibrated blood glucose value increments;

[0041] determining a relationship between the oral temperature increment and the blood glucose increment based on a plurality of oral calibration temperature increments and corresponding blood glucose value increments;

[0042] According to the relationship between the oral temperature increment and the blood glucose increment, the target oral temperature increment is converted to obtain the target blood glucose increment.

[0043] To achieve the above-mentioned purpose, the second aspect of the embodiments of the present application proposes an electronic device, which includes a memory and a processor, wherein the memory stores a computer program, and when the processor executes the computer program, the method described in the embodiment of the first aspect is implemented.

[0044] To achieve the above-mentioned purpose, the third aspect of the embodiment of the present application proposes a storage medium, which is a computer-readable storage medium and stores a computer program. When the computer program is executed by a processor, the method described in the embodiment of the first aspect is implemented.

[0045] The embodiments of the present application have the following beneficial effects: the present application first obtains the target tympanic membrane temperature, and then estimates the target oral temperature through a pre-established temperature correspondence between the tympanic membrane and the oral cavity, and then establishes a temperature correspondence between the blood glucose increment and the oral temperature increment through a pre-calibrated invasive blood glucose value and an oral calibration temperature, thereby being able to deduce the target blood glucose increment, and finally deduce the target blood glucose value based on the target blood glucose increment and the pre-calibrated invasive blood glucose value, thereby improving the physical sensitivity of the blood glucose measurement process and reducing the influence of other factors on the blood glucose measurement. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] FIG1 is a flow chart of a blood glucose measurement method provided by some embodiments of the present application;

[0047] FIG2 is a flow chart of a blood glucose measurement method provided by other embodiments of the present application;

[0048] FIG3 is a flow chart of a blood glucose measurement method provided by other embodiments of the present application;

[0049] FIG4 is a flow chart of a blood glucose measurement method provided by other embodiments of the present application;

[0050] FIG5 is a flow chart of a blood glucose measurement method provided by other embodiments of the present application;

[0051] FIG6 is a flow chart of a blood glucose measurement method provided by other embodiments of the present application;

[0052] FIG7 is a graph showing a universal relationship curve equation between the ambient temperature and the difference between the tympanic membrane temperature and the oral temperature of multiple volunteers provided in some embodiments of the present application;

[0053] FIG8 is a comparison diagram of a relationship curve and an equation of a universal relationship curve between the ambient temperature of volunteer B and the difference between the tympanic membrane temperature and the oral temperature, provided in some embodiments of the present application;

[0054] FIG9 is a comparison diagram of a relationship curve and an equation of a universal relationship curve between the ambient temperature of volunteer C and the difference between the tympanic membrane temperature and the oral temperature, provided in some embodiments of the present application;

[0055] FIG10 is a flow chart of a blood glucose measurement method provided by other embodiments of the present application;

[0056] FIG11 is a flow chart of a blood glucose measurement method provided in some other embodiments of the present application;

[0057] FIG12 is a dynamic curve diagram of the tympanic membrane temperature of volunteer D over 24 hours, provided by some embodiments of the present application;

[0058] FIG13 is a schematic diagram of the hardware structure of an electronic device provided in some embodiments of the present application. DETAILED DESCRIPTION

[0059] In order to make the purpose, technical solutions and advantages of this application more clear, the following further describes this application in detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application.

[0060] In the description of this application, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on this application.

[0061] It should also be noted that, in the description of this application, "several" means more than one, "plurality" means more than two, "greater than," "less than," and "exceed" are understood to exclude the number itself, while "above," "below," and "within" are understood to include the number itself. The use of "first" and "second" in the description is solely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, implicitly specifying the number of the indicated technical features, or implicitly specifying the order of the indicated technical features.

[0062] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this application pertains. The terms used herein are for the purpose of describing the embodiments of this application only and are not intended to limit this application.

[0063] In the description of this application, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of this application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in any appropriate manner in any one or more embodiments or examples.

[0064] First, let’s analyze some of the terms used in this application:

[0065] Non-invasive blood glucose testing technology: Non-invasive blood glucose testing technology refers to a method for measuring blood glucose levels without the need for a puncture or blood sample. Traditional blood glucose testing typically requires a needle or pulse oximeter to collect a drop of blood for measurement. Non-invasive blood glucose testing technology avoids this uncomfortable and painful process, achieving blood glucose monitoring through a non-invasive method.

[0066] Among the existing technologies, most non-invasive blood glucose monitoring technologies monitor blood glucose levels by measuring the temperature of the finger skin or the temperature of the mouth. However, measuring blood glucose levels by measuring the temperature of the finger skin is often easily affected by the external temperature environment and leads to inaccurate measurements. Measuring blood glucose levels by measuring the temperature of the mouth makes the monitoring process cumbersome and requires frequent opening of the mouth to measure the oral temperature, which is not user-friendly in terms of monitoring body sensation.

[0067] Based on this, an embodiment of the present application provides a blood glucose measurement method, which first obtains the target tympanic membrane temperature, and then estimates the target oral temperature through a pre-established temperature correspondence between the tympanic membrane and the oral cavity, and then establishes a temperature correspondence between the blood glucose increment and the oral temperature increment through a pre-calibrated invasive blood glucose value and an oral calibration temperature, thereby being able to calculate the target blood glucose increment, and finally calculating the target blood glucose value based on the target blood glucose increment and the pre-calibrated invasive blood glucose value, thereby improving the physical sensitivity of the blood glucose measurement process and reducing the impact of other factors on the blood glucose measurement.

[0068] The blood glucose measurement method provided in the embodiment of the present application is specifically illustrated by the following examples. First, the tympanic membrane temperature measurement device in the embodiment of the present application is described.

[0069] 1 , which is a flow chart of a blood glucose measurement method provided in some other embodiments of the present application, the blood glucose measurement method may include but is not limited to step S110 , step S120 , step S130 and step S140 .

[0070] Step S110: obtaining a target eardrum temperature and a target ambient temperature;

[0071] It should be noted that both the target tympanic membrane temperature and the target ambient temperature need to be acquired under a constant ambient temperature, wherein the constant duration can be 1 hour, 2 hours, or 5 hours.

[0072] Step S120: converting the target ambient temperature based on the relationship between the ambient temperature and the temperature difference between the eardrum and the oral cavity to obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature;

[0073] It should be noted that, based on the relationship between the ambient temperature and the temperature difference between the eardrum and the oral cavity, the temperature difference at the current target ambient temperature is fitted and predicted to obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature, wherein the relationship between the ambient temperature and the temperature difference between the eardrum and the oral cavity is fitted through calibration data.

[0074] Step S130: converting the target tympanic membrane temperature according to the temperature difference to obtain the target oral temperature;

[0075] It should be noted that the target tympanic membrane temperature and the temperature difference are summed to obtain the target oral temperature.

[0076] Step S140: According to the relationship between oral temperature and blood glucose, the target oral temperature is converted into a corresponding blood glucose value to obtain the target blood glucose value.

[0077] It should be noted that the relationship between oral temperature and blood sugar is fitted using calibration data.

[0078] 2 , which is a flow chart of a blood glucose measurement method provided in some other embodiments of the present application, the blood glucose measurement method may include but is not limited to step S210 , step S220 , step S230 and step S240 .

[0079] Step S210: obtaining a plurality of environmental calibration temperatures and their corresponding tympanic membrane calibration temperatures and oral cavity calibration temperatures;

[0080] It should be noted that multiple environmental calibration temperatures can be detected and acquired within 24 hours, and can be acquired before and after times when the ambient temperature difference is large, which can be the time interval of 5:30 to 6:30 in the early morning, the time interval of 12:30 to 13:30 at noon, the time interval of 16:30 to 18:30 in the afternoon, or the time interval of 22:30 to 25:00. This application does not make specific limitations.

[0081] Furthermore, the oral cavity calibration temperature requires calibration and detection of the oral cavity through an oral temperature measuring device.

[0082] Step S220: calculating the difference between the tympanic membrane calibration temperature and the oral cavity calibration temperature at each environmental calibration temperature according to the environmental calibration temperature, and obtaining the temperature difference between the tympanic membrane and the oral cavity at multiple environmental calibration temperatures;

[0083] It should be noted that the calculation of the difference between the tympanic membrane calibration temperature and the oral calibration temperature can be performed by calculating the average of multiple tympanic membrane calibration temperatures and the average of multiple oral calibration temperatures at the same ambient temperature and then taking the difference between the two, or by calculating the difference between multiple tympanic membrane calibration temperatures and oral calibration temperatures and then taking the average. This application does not make any specific restrictions.

[0084] Step S230: determining a target temperature difference relationship between the eardrum and the oral cavity at different ambient temperatures based on a plurality of ambient calibration temperatures and their corresponding temperature differences;

[0085] It should be noted that in the fitting relationship curve of the target temperature difference between the tympanic membrane and the oral cavity under different ambient temperatures, the X-axis is the ambient temperature, and the Y-axis is the target temperature difference between the tympanic membrane and the oral cavity, and the curve can be a linear equation curve, a quadratic equation curve, or an N-order equation curve, which is not specifically limited in this application.

[0086] Step S240: performing a relationship conversion on the target ambient temperature according to the target temperature difference relationship to obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature.

[0087] Furthermore, the Y value corresponding to the X axis of the target ambient temperature on the fitting relationship curve is used as the temperature difference between the eardrum and the oral cavity at the target ambient temperature.

[0088] 3 , which is a flow chart of a blood glucose measurement method provided in some other embodiments of the present application, the blood glucose measurement method may include but is not limited to step S310 , step S320 , and step S330 .

[0089] Step S310: obtaining a universal temperature difference relationship between the eardrum and the oral cavity as a first temperature difference relationship;

[0090] It should be noted that since everyone's physique is different, the temperature difference between the eardrum and the mouth is also different for each person. The universal temperature difference relationship is fitted by collecting the average temperature difference between the eardrum and the mouth of the public at different ambient temperatures. It represents the average level of the temperature difference between the eardrum and the mouth of most people at different ambient temperatures.

[0091] Step S320: determining a temperature difference relationship between the eardrum and the oral cavity at different ambient temperatures based on the multiple ambient calibration temperatures and the corresponding temperature differences as a second temperature difference relationship;

[0092] It should be noted that the second temperature difference relationship is the temperature difference relationship between the eardrum and the oral cavity of the user under different ambient temperatures, which is obtained by fitting the user's own ambient calibration temperature, eardrum calibration temperature and oral calibration temperature.

[0093] Step S330: Under the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain a target temperature difference relationship.

[0094] Specifically, because individuals are easily affected by the external environment during the measurement process, there are certain errors in the measured ambient calibration temperature, tympanic membrane calibration temperature and oral calibration temperature, and thus the fitted temperature difference relationship between the tympanic membrane and the oral cavity under different ambient temperatures of the individual may have certain errors. It is necessary to correct the individual temperature difference relationship through the universal temperature difference relationship to make the fitting result more accurate, thereby improving the accuracy of subsequent blood glucose conversion.

[0095] 4 , which is a flow chart of a blood glucose measurement method provided in some other embodiments of the present application, the blood glucose measurement method may include but is not limited to step S410 and step S420 .

[0096] Step S410: If the absolute value of the relationship difference is less than a preset threshold, the second temperature difference relationship is used as the target temperature difference relationship;

[0097] It should be noted that, if the absolute value of the first temperature difference relationship is less than a preset threshold value at the same ambient temperature, and the second temperature difference relationship is within a reasonable error range, the second temperature difference relationship is used as the target temperature difference relationship.

[0098] Step S420: Alternatively, if the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is shifted up and down in the corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship.

[0099] It should be noted that if the absolute value of the relationship difference is greater than or equal to the preset threshold, the second temperature difference relationship is outside the reasonable error range, and the relationship curve of the first temperature difference relationship needs to be translated up and down in the corresponding direction according to the relationship difference. The displacement of the translation is determined by the size of the difference, and the direction of the translation is determined by the positive or negative sign of the difference.

[0100] Furthermore, the value of the relationship difference can be the difference between the average temperature difference of the first temperature difference relationship and the average temperature difference of the second temperature difference relationship, or the difference between the temperature difference of the first temperature difference relationship and the temperature difference of the second temperature difference relationship at the same temperature, or the average difference between the temperature difference of the first temperature difference relationship and the temperature difference of the second temperature difference relationship at multiple temperatures.

[0101] Referring to FIG. 5 , FIG. 5 is a flowchart of a blood glucose measurement method provided in some other embodiments of the present application. The blood glucose measurement method may include but is not limited to step S510 and step S520 .

[0102] Step S510: when the relationship difference is a positive number, the relationship curve of the first temperature difference relationship is shifted downward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship;

[0103] It should be noted that when the relationship difference is positive, the relationship curve of the first temperature difference relationship is above the coordinate axis of the relationship curve of the second temperature difference relationship. It is necessary to shift the relationship curve of the first temperature difference relationship downward by the displacement of the relationship difference, and then use the shifted first temperature difference relationship as the target temperature difference relationship.

[0104] Step S520: Alternatively, when the relationship difference is a negative number, the relationship curve of the first temperature difference relationship is shifted upward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship.

[0105] It should be noted that when the relationship difference is negative, the relationship curve of the first temperature difference relationship is below the coordinate axis of the relationship curve of the second temperature difference relationship. The relationship curve of the first temperature difference relationship needs to be shifted upward by the displacement of the relationship difference, and then the first temperature difference relationship after the shift is used as the target temperature difference relationship.

[0106] 6 , which is a flow chart of a blood glucose measurement method provided in some other embodiments of the present application, the blood glucose measurement method may include but is not limited to step S610 , step S620 , step S630 and step S640 .

[0107] Step S610: Acquire multiple ambient universal temperatures and corresponding tympanic membrane universal temperatures and oral cavity universal temperatures;

[0108] Specifically, the above universal parameters require multiple users to perform multiple tympanic membrane temperature and oral temperature measurements at different ambient temperatures within the same preset ambient temperature range in the same area, and the users need to maintain a constant state at the same ambient temperature for a period of time, and temperature measurement will only be performed when the preset time measurement threshold is exceeded.

[0109] Furthermore, the above-mentioned preset ambient temperature range can be 5°C to 30°C, 10°C to 35°C, 5°C to 35°C, or 8°C to 37°C, and this application does not make any specific limitations.

[0110] Furthermore, the above-mentioned preset time measurement threshold may be 10 minutes, 15 minutes, 30 minutes, or 1 hour, and this application does not make any specific limitation.

[0111] Step S620: Calculating the difference between the universal temperature of the tympanic membrane and the universal temperature of the oral cavity at each universal temperature according to the universal temperature of the environment, and obtaining a first universal temperature difference between the tympanic membrane and the oral cavity at the plurality of universal temperatures of the environment;

[0112] It should be noted that the first universal temperature difference between the eardrum and the oral cavity under multiple universal ambient temperatures is the first universal temperature difference between the eardrum and the oral cavity under multiple universal ambient temperatures of multiple users.

[0113] Step S630: performing data dimensionality reduction on the first universal temperature difference under different environmental universal temperatures to obtain a second universal temperature difference under different environmental universal temperatures;

[0114] It should be noted that since the first universal temperature difference value includes the first universal temperature difference value of multiple users, there are multiple user-specific temperature difference relationship curves. The first universal temperature difference value needs to be converted from a two-dimensional parameter to a one-dimensional parameter to obtain the corresponding universal temperature difference relationship curve. The dimensionality reduction method can be to take the average value of the temperature difference between the eardrum and the mouth of multiple users at the same ambient temperature, or to take the median value of the temperature difference between the eardrum and the mouth of multiple users at the same ambient temperature, so that each ambient temperature on the X-axis of the coordinate axis has only one corresponding universal temperature difference between the eardrum and the mouth.

[0115] Step S640: According to the plurality of ambient universal temperatures and their corresponding second universal temperature differences, a universal temperature difference relationship between the eardrum and the oral cavity at different universal ambient temperatures is determined and used as a first temperature difference relationship.

[0116] It should be noted that the relationship curve of the universal temperature difference relationship can be a quadratic equation curve, a cubic equation curve, or an Nth-order equation curve.

[0117] The blood glucose measurement method of the present application is further described in detail below through another example.

[0118] Multiple volunteers are gathered in the same room equipped with an air-conditioning system. The air-conditioning system is used to control the temperature of blood glucose monitoring within the range of 5°C to 30°C. Multiple indoor ambient temperatures are set to 5°C, 10°C, 15°C, 20°C, 25°C and 30°C, respectively. Each volunteer is then asked to maintain each temperature test point for at least 15 minutes. The universal oral temperature and universal tympanic membrane temperature of each volunteer at the above ambient temperature are measured respectively. The universal difference between the two is calculated and the average is taken. According to the average of the universal difference between the oral temperature and the tympanic membrane temperature and the corresponding ambient temperature, a relationship curve equation is constructed to obtain the universal temperature difference relationship between the tympanic membrane and the oral cavity. Figure 7 is a diagram of the universal relationship curve equation between the ambient temperature of multiple volunteers and the difference between the tympanic membrane temperature and the oral temperature provided in some embodiments of the present application. It can be seen that the universal relationship curve equation between the oral temperature and the tympanic membrane temperature is:

[0119] (1)DT=-0.0008Th2+0.05Th+0.225;

[0120] Where DT represents the universal difference between the tympanic membrane and the oral cavity temperature, and Th represents the universal ambient temperature.

[0121] The blood glucose measurement method of the present application is further described in detail below through another example.

[0122] During the calibration process before blood glucose monitoring, volunteer B obtained the difference between the tympanic membrane calibration temperature and the oral calibration temperature at 11 ambient temperatures, where three moments with large ambient temperature differences can be selected: the state before eating breakfast at 6:30 (ambient temperature of 13.3°C), the state before eating lunch at 11:50 (ambient temperature of 16.6°C), and the state 2 hours after eating lunch at 15:25 (ambient temperature of 23.2°C). The differences between the tympanic membrane calibration temperature and the oral calibration temperature are 0.611°C, 0.670°C, and 0.753°C, respectively. As shown in FIG8 , FIG8 is a comparison diagram of the relationship curve between the ambient temperature of volunteer B and the difference between the tympanic membrane temperature and the oral temperature and the equation of the universal relationship curve provided in some embodiments of the present application. It can be seen that the relationship curve equation between the ambient temperature of volunteer B and the difference between the tympanic membrane temperature and the oral temperature is:

[0123] (2) DT = -0.0007T h 2 +0.0385T h +0.2212;

[0124] Where DT represents the temperature difference between the eardrum and oral cavity of volunteer B, T h Represents the ambient temperature.

[0125] Comparing the above equations (1) and (2), it can be seen that the coefficients of the relationship curve of volunteer B are not significantly different from the average coefficient of the universal relationship curve, indicating that the difference relationship between the tympanic membrane temperature and oral temperature obtained by volunteer B during the calibration process is reasonable. Through mathematical simulation, the relationship can be extended to lower or higher ambient temperatures, such as as low as 5°C or as high as 30°C, as a difference equation suitable for volunteer B personally.

[0126] The blood glucose measurement method of the present application is further described in detail below through another example.

[0127] The ambient temperature of volunteer C during the calibration process was concentrated around 25°C, with an average of 25.2°C. The tympanic membrane temperature and oral temperature of volunteer C were measured before breakfast, before lunch, before dinner, and after dinner over 25 hours, as shown in Figure 9. Figure 9 is a comparison diagram of the relationship curve between the ambient temperature of volunteer C and the difference between the tympanic membrane temperature and oral temperature, and the equation of the universal relationship curve provided in some embodiments of the present application. It can be seen that the average of the difference between the tympanic membrane temperature and oral temperature of volunteer C when the ambient temperature is 25.2°C is 0.651°C, which is 0.1092°C lower than the average of the difference of 0.7502°C when the ambient temperature is 25.2°C on the universal relationship curve mentioned above. The universal curve needs to be shifted downward by 0.1092°C to obtain a difference curve suitable for volunteer C personally. The equation of the relationship curve between the ambient temperature of volunteer C and the difference between the tympanic membrane temperature and oral temperature is:

[0128] (3) DT = -0.008T h 2 +0.051T h +0.1158;

[0129] Where DT represents the temperature difference between the eardrum and oral cavity of volunteer C, T h Represents the ambient temperature.

[0130] Referring to FIG. 10 , FIG. 10 is a flowchart of a blood glucose measurement method provided in some other embodiments of the present application. The blood glucose measurement method may include but is not limited to step S1010 , step S1020 , step S1030 and step S1040 .

[0131] Step S1010: obtaining a calibrated blood glucose value and an oral calibration temperature before measuring the oral temperature, wherein the calibrated blood glucose value is calibrated in an invasive manner;

[0132] Specifically, the time required to measure the calibrated blood glucose value during the calibration process is 24 hours. The time points that need to be measured are before breakfast, 1 hour after breakfast, 2 hours after breakfast, before lunch, 1 hour after lunch, 2 hours after lunch, before dinner, 1 hour after dinner, 2 hours after dinner, before bedtime and when getting up at midnight. A total of 11 calibrated blood glucose values ​​are measured.

[0133] Furthermore, the blood glucose value is calibrated in an invasive manner, which may be done by fingertip blood sampling, arm vein blood sampling, or hand back vein blood sampling, and this application does not limit this.

[0134] Step S1020: Obtaining a target oral temperature increment according to the target oral temperature and the oral calibration temperature;

[0135] It should be noted that the oral calibration temperature is the oral calibration temperature measured at the time when the target eardrum is measured, which is closest to the aforementioned calibration time. The target oral temperature and the oral calibration temperature are subtracted to obtain the target oral temperature increment.

[0136] Step S1030: converting the target oral temperature increment based on the relationship between the oral temperature increment and the blood glucose increment to obtain the target blood glucose increment;

[0137] It should be noted that in the fitting relationship curve of the relationship between the oral temperature increment and the blood glucose increment, the X-axis is the oral temperature increment, and the Y-axis is the blood glucose increment, and the curve can be a linear equation curve, a quadratic equation curve, or an N-order equation curve, which is not specifically limited in this application.

[0138] To further explain, the target blood glucose increment can be a positive number, a negative number, or zero.

[0139] Step S1040: Obtain the target blood glucose value according to the calibrated blood glucose value and the target blood glucose increment.

[0140] It should also be noted that the calibrated blood glucose value is the calibrated blood glucose value measured at the time when the target eardrum is measured, which is closest to the above-mentioned calibration time. The target blood glucose value is obtained by adding the calibrated blood glucose value to the target blood glucose increment.

[0141] Referring to FIG. 11 , FIG. 11 is a flowchart of a blood glucose measurement method provided in some other embodiments of the present application. The blood glucose measurement method may include but is not limited to steps S1110 , S1120 , S1130 , step S1140 and step S1150 .

[0142] Step S1110: Acquire multiple oral calibrated temperatures and multiple calibrated blood glucose values;

[0143] Specifically, the multiple calibrated oral temperatures and the multiple calibrated blood glucose values ​​are the oral temperatures and invasive blood glucose values ​​obtained at the aforementioned 11 times.

[0144] Step S1120: Calculating the differences between the oral calibration temperatures at adjacent times based on the multiple oral calibration temperatures to obtain multiple oral calibration temperature increments;

[0145] Specifically, when the oral calibration temperature is the oral temperature obtained at the above 11 times, by calculating the difference between the oral calibration temperatures at adjacent times, 10 oral calibration temperature increments will be obtained.

[0146] Step S1130: Calculating the differences between the calibrated blood glucose values ​​at adjacent times based on the multiple calibrated blood glucose values ​​to obtain multiple calibrated blood glucose value increments;

[0147] Specifically, when the calibrated blood glucose value is the invasive blood glucose value obtained at the above 11 times, by calculating the difference between the calibrated blood glucose values ​​at adjacent times, 10 calibrated blood glucose value increments will be obtained.

[0148] Step S1140: determining a relationship between the oral temperature increment and the blood glucose increment based on a plurality of oral calibration temperature increments and corresponding blood glucose value increments;

[0149] It should be noted that in the fitting relationship curve of the relationship between the oral temperature increment and the blood glucose increment, the X-axis is the oral temperature increment, and the Y-axis is the blood glucose increment, and the curve can be a linear equation curve, a quadratic equation curve, or an N-order equation curve, which is not specifically limited in this application.

[0150] Step S1150: According to the relationship between the oral temperature increment and the blood glucose increment, the target oral temperature increment is converted to obtain the target blood glucose increment.

[0151] It should be noted that the Y value corresponding to the X-axis of the target oral temperature on the fitting relationship curve is used as the target blood glucose increment.

[0152] The blood glucose measurement method of the present application is further described in detail below through another example.

[0153] After the calibration of the method in the above embodiment was completed, volunteer D underwent dynamic blood glucose monitoring, as shown in Figure 12. Figure 12 is a dynamic curve of the tympanic membrane temperature of volunteer D within 25 hours provided by some embodiments of the present application. It can be seen that the curve has three peaks, which correspond to three meals (meal times are: 6:53, 12:55 and 18:50 respectively). The increase in tympanic membrane temperature caused by the increase in metabolic heat due to increased blood glucose reflects the positive correlation between tympanic membrane temperature and blood glucose, that is, the tympanic membrane temperature will also increase when blood glucose increases.

[0154] The present application also provides an electronic device comprising a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the aforementioned blood glucose measurement method and temperature curve relationship calibration method. The electronic device can be any smart terminal, including a mobile phone, a tablet computer, and an in-vehicle computer.

[0155] Please refer to FIG13 , which illustrates a hardware structure of an electronic device provided by some embodiments. The electronic device includes:

[0156] The processor 1301 can be implemented as a general-purpose CPU (Central Processing Unit), a microprocessor, an application-specific integrated circuit (ASIC), or one or more integrated circuits, and is configured to execute relevant programs to implement the tympanic membrane temperature measurement method, blood glucose measurement method, and temperature curve relationship calibration method provided in the embodiments of the present application;

[0157] The memory 1302 can be implemented in the form of a read-only memory (ROM), a static storage device, a dynamic storage device, or a random access memory (RAM). The memory 1302 can store an operating system and other application programs. When the technical solutions provided in the embodiments of this specification are implemented through software or firmware, the relevant program code is stored in the memory 1302 and is called by the processor 1301 to execute the blood glucose measurement method provided in the embodiments of this application.

[0158] Input / output interface 1303, used to implement information input and output;

[0159] Communication interface 1305, used to implement communication interaction between this device and other devices, which can be achieved through wired means (such as USB, network cable, etc.) or wireless means (such as mobile network, WiFi, Bluetooth, etc.);

[0160] Bus 1305 , which transmits information between various components of the device (e.g., processor 1301 , memory 1302 , input / output interface 1303 , and communication interface 1305 );

[0161] The processor 1301 , the memory 1302 , the input / output interface 1303 and the communication interface 1305 are connected to each other in communication within the device via the bus 1305 .

[0162] An embodiment of the present application further provides a computer-readable storage medium storing a computer program. When the computer program is executed by a processor, the blood glucose measurement method provided in the embodiment of the present application is implemented.

[0163] The memory, as a non-transient computer-readable storage medium, can be used to store non-transient software programs and non-transient computer executable programs. In addition, the memory may include a high-speed random access memory and may also include a non-transient memory, such as at least one disk storage device, a flash memory device, or other non-transient solid-state storage device. In some embodiments, the memory may optionally include a memory remotely arranged relative to the processor, and these remote memories may be connected to the processor via a network. Examples of the above-mentioned network include, but are not limited to, the Internet, an intranet, a local area network, a mobile communication network, and combinations thereof.

[0164] The embodiments described in the embodiments of this application are intended to more clearly illustrate the technical solutions of the embodiments of this application and do not constitute a limitation on the technical solutions provided by the embodiments of this application. Those skilled in the art will appreciate that with the evolution of technology and the emergence of new application scenarios, the technical solutions provided in the embodiments of this application are also applicable to similar technical problems.

[0165] Those skilled in the art will understand that the technical solutions shown in the figures do not constitute a limitation on the embodiments of the present application, and may include more or fewer steps than shown in the figures, or a combination of certain steps, or different steps.

[0166] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate, i.e., they may be located in one place or distributed across multiple network units. Some or all of the modules may be selected based on actual needs to achieve the objectives of this embodiment.

[0167] Those skilled in the art will appreciate that all or some of the steps in the methods, systems, and functional modules / units in the devices disclosed above may be implemented as software, firmware, hardware, or appropriate combinations thereof.

[0168] The terms "first", "second", "third", "fourth", etc. (if any) in the specification of the present application and the above-mentioned drawings are used to distinguish similar objects and are not necessarily used to describe a specific order or sequential order. It should be understood that the data used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0169] It should be understood that in this application, "at least one (item)" means one or more, and "plurality" means two or more. "And / or" is used to describe the association relationship of associated objects, indicating that three relationships may exist. For example, "A and / or B" can mean: only A exists, only B exists, and A and B exist at the same time, where A and B can be singular or plural. The character " / " generally indicates that the previous and next associated objects are in an "or" relationship. "At least one of the following items" or similar expressions refers to any combination of these items, including any combination of single items or plural items. For example, at least one of a, b or c can mean: a, b, c, "a and b", "a and c", "b and c", or "a and b and c", where a, b, c can be single or multiple.

[0170] In the several embodiments provided in this application, it should be understood that the disclosed systems and methods can be implemented in other ways. For example, the system embodiments described above are merely illustrative. For example, the division of the above units is merely a logical function division. In actual implementation, there may be other division methods, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be an indirect coupling or communication connection through some interfaces, devices or units, which can be electrical, mechanical or other forms.

[0171] The units described above as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed across multiple network units. Some or all of these units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0172] In addition, the functional units in the various embodiments of the present application may be integrated into a single processing unit, or each unit may exist physically separately, or two or more units may be integrated into a single unit. The aforementioned integrated units may be implemented in the form of hardware or software functional units.

[0173] If the integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or all or part of the technical solution can be embodied in the form of a software product, which is stored in a storage medium and includes multiple instructions for enabling a computer device (which can be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods of various embodiments of the present application. The aforementioned storage medium includes: various media that can store programs, such as a USB flash drive, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk.

[0174] The preferred embodiments of the present invention are described above with reference to the accompanying drawings, but are not intended to limit the scope of the present invention. Any modifications, equivalent substitutions, and improvements made by those skilled in the art without departing from the scope and essence of the present invention should be within the scope of the present invention.

Claims

1. A method for measuring blood sugar, comprising: Obtaining a target tympanic membrane temperature and a target ambient temperature; According to the relationship between the ambient temperature and the temperature difference between the eardrum and the oral cavity, the target ambient temperature is converted to obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature; According to the temperature difference, the target tympanic membrane temperature is converted to obtain a target oral temperature; According to the relationship between oral temperature and blood sugar, the target oral temperature is converted into a corresponding blood sugar value to obtain a target blood sugar value.

2. The blood sugar measuring method according to claim 1, wherein: The target ambient temperature is converted according to the relationship between the ambient temperature and the temperature difference between the tympanic membrane and the oral cavity to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature, including: Obtain multiple environmental calibration temperatures and their corresponding tympanic membrane calibration temperatures and oral cavity calibration temperatures; According to the environmental calibration temperature, calculating the difference between the tympanic membrane calibration temperature and the oral cavity calibration temperature at each of the environmental calibration temperatures, and obtaining the temperature difference between the tympanic membrane and the oral cavity at multiple environmental calibration temperatures; Determining a target temperature difference relationship between the eardrum and the oral cavity at different ambient temperatures according to the plurality of ambient calibration temperatures and their corresponding temperature differences; The target ambient temperature is converted according to the target temperature difference relationship to obtain the temperature difference between the eardrum and the oral cavity at the target ambient temperature.

3. The blood sugar measuring method according to claim 2, wherein: The determining of the target temperature difference relationship between the eardrum and the oral cavity at different ambient temperatures according to the plurality of ambient calibration temperatures and the corresponding temperature differences includes: Acquire a universal temperature difference relationship between the eardrum and the oral cavity as a first temperature difference relationship; Determining, according to the plurality of the environmental calibration temperatures and the corresponding temperature differences, a temperature difference relationship between the eardrum and the oral cavity at different environmental temperatures as a second temperature difference relationship; Under the same ambient temperature, the relationship difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain a target temperature difference relationship.

4. The blood sugar measuring method according to claim 3, wherein: At the same ambient temperature, the relationship difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain a target temperature difference relationship, and obtaining the target temperature difference relationship includes: If the absolute value of the relationship difference is less than a preset threshold, taking the second temperature difference relationship as a target temperature difference relationship; or, If the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is translated up and down in a corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is translated is obtained as the target temperature difference relationship.

5. The blood sugar measuring method according to claim 4, wherein: If the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is translated up and down in a corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is translated is obtained as the target temperature difference relationship, including: When the relationship difference is a positive number, the relationship curve of the first temperature difference relationship is shifted downward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship; or, When the relationship difference is a negative number, the relationship curve of the first temperature difference relationship is shifted upward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is obtained as the target temperature difference relationship.

6. The blood sugar measuring method according to claim 3, wherein: The step of obtaining a universal temperature difference relationship between the eardrum and the oral cavity as a first temperature difference relationship includes: Acquire multiple environmental universal temperatures, and corresponding tympanic membrane universal temperatures and oral universal temperatures under the multiple environmental universal temperatures; Calculate the difference between the universal temperature of the eardrum and the universal temperature of the oral cavity at each universal temperature of the environment according to the universal temperature of the environment, and obtain a plurality of first universal temperature differences between the eardrum and the oral cavity at the universal temperature of the environment; Performing data dimension reduction on the first universal temperature difference under different environmental universal temperatures to obtain the second universal temperature difference under different environmental universal temperatures; According to the plurality of the universal ambient temperatures and the corresponding second universal temperature differences, a universal temperature difference relationship between the eardrum and the oral cavity at different universal ambient temperatures is determined and used as a first temperature difference relationship.

7. The blood sugar measuring method according to claim 1, wherein: The step of converting the target oral temperature into a corresponding blood glucose value according to the relationship between the oral temperature and the blood glucose to obtain the target blood glucose value includes: Obtaining a calibrated blood sugar value and an oral calibrated temperature before measuring the oral temperature, wherein the calibrated blood sugar value is calibrated in an invasive manner; Obtaining a target oral temperature increment according to the target oral temperature and the oral calibration temperature; According to the relationship between the oral temperature increment and the blood sugar increment, the target oral temperature increment is converted to obtain the target blood sugar increment; A target blood glucose value is obtained according to the calibrated blood glucose value and the target blood glucose increment.

8. The blood sugar measuring method according to claim 7, wherein: The step of converting the target oral temperature increment according to the relationship between the oral temperature increment and the blood sugar increment to obtain the target blood sugar increment includes: Obtaining multiple oral calibrated temperatures and multiple calibrated blood sugar values; According to the plurality of oral calibration temperatures, the differences between the oral calibration temperatures at adjacent times are calculated in sequence to obtain a plurality of oral calibration temperature increments; According to the plurality of calibrated blood glucose values, sequentially calculating the differences between the calibrated blood glucose values ​​at adjacent times to obtain a plurality of calibrated blood glucose value increments; Determining the relationship between the oral temperature increment and the blood glucose increment according to the plurality of oral calibrated temperature increments and the corresponding blood glucose value increments; According to the relationship between the oral temperature increment and the blood sugar increment, the target oral temperature increment is converted to obtain the target blood sugar increment.

9. An electronic device, comprising: at least one processor; at least one memory for storing at least one program; When at least one of the programs is executed by at least one of the processors, the blood glucose measurement method according to any one of claims 1 to 9 is implemented.

10. A computer-readable storage medium storing a program executable by a processor, wherein the program executable by the processor is used to implement the blood glucose measurement method according to any one of claims 1 to 9 when executed by the processor.

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