Nutritional composition, preparation method therefor, and use thereof

Abstract

The present invention belongs to the technical field of food. Specifically, disclosed are a nutritional composition, a preparation method therefor, and the use thereof. The nutritional composition is prepared from the following raw materials in parts by weight: 257-295 parts of protein substances, 383-395 parts of fat substances, 632-770 parts of carbohydrate, 58-60 parts of dietary fiber substances, 4.7-5.6 parts of complex trace minerals, 106 to 119 parts of complex macro minerals, 10.7 to 12.9 parts of complex vitamin, 6.21 to 7.62 parts of choline bitartrate, 0.986 to 1.1 parts of L-carnitine, and 0.42 to 0.762 part of taurine. The present invention relates to the nutritionally comprehensive and reasonably-mixed nutritional composition, which can comprehensively supplement people of low immunity with nutrients required by bodies, so as to achieve the purposes of regulating body functions, boosting immunity, strengthening bones, ameliorating constipation, promoting the recovery of the body functions and improving life quality.

Description

Nutritional composition, preparation method and use thereof Technical Field

[0001] The present invention belongs to the field of food technology, and in particular relates to a nutritional composition, a preparation method and an application thereof. Background Art

[0002] Immunity plays a vital role in the body's ability to resist infection with specific pathogens and prevent the development of disease. Adequate and balanced nutrition is an effective safeguard for enhancing immunity. Malnutrition weakens the immune system, allowing infections, cancer, and other diseases to take advantage. When nutrients are adequately supplied, appropriately supplied, and balanced, the immune system is optimal, resulting in good health and strong immunity. In clinical practice, a patient's nutritional status is crucial for disease treatment and overall health outcomes. Good nutritional status can help reduce complications, mortality, prognosis, hospitalization time, and economic costs. Some patients are unable or unwilling to consume food orally for health reasons, thus failing to meet their nutritional needs. In particular, patients with cancer, severe infection, or major trauma often experience increased damage due to insufficient nutritional support. Therefore, providing scientifically sound nutritional support is essential for patients at risk of malnutrition or nutritional risk.

[0003] As adults age, bone formation and bone resorption become negatively balanced. Bone density reaches its peak around the age of 35 and then continues to decline, which can easily lead to fractures and even limit or lose trunk movement function. Therefore, maintaining bone health and preventing osteoporosis are crucial to improving the quality of life of adults. Scientific and reasonable nutritional supplementation is one of the important factors affecting bone health. Calcium supplementation is currently the most common method to promote bone health, but it can also easily cause adverse symptoms such as constipation. Compared with ordinary foods, nutritional compositions with clear ingredients, comprehensive nutrition, and reasonable combinations are more helpful in improving patients' immunity and strengthening bones. They are of great significance in improving patients' malnutrition, promoting disease recovery, and improving quality of life.

[0004] Patent CN101828707 discloses a nutritional composition that enhances immunity and prevents osteoporosis. However, this composition primarily regulates body functions by promoting the bioavailability of calcium. Consequently, it suffers from the common adverse symptom of constipation associated with current calcium-based nutritional supplements. There is a need to develop a nutritionally balanced product that can enhance immunity, strengthen bones, and improve body functions.

[0005] Summary of the Invention

[0006] To solve the above problems, the present invention provides a nutritional composition for enhancing immunity, strengthening bones and / or improving constipation, which is composed of the following raw materials in the following weight ratios:

[0007] 257-295 parts of protein, 383-395 parts of fat, 632-770 parts of carbohydrates, 58-60 parts of dietary fiber, 4.7-5.1 parts of complex trace minerals, 106-119 parts of complex macrominerals, 10.7-12.9 parts of complex vitamins, 6.21-7.62 parts of choline bitartrate, 0.986-1.1 parts of L-carnitine, 0.42-0.762 parts of taurine;

[0008] The protein material is composed of 37-47 parts of whey protein, 96-112 parts of soy protein and 98-162 parts of casein;

[0009] The fat substance is a vegetable oil microcapsule powder made from 66-71 parts of medium-chain triglycerides, 62-79 parts of sunflower oil, 51-57 parts of soybean oil, 72-88 parts of low-erucic acid rapeseed oil, and 115-117 parts of an edible carrier; the edible carrier is composed of 68-70 parts of maltooligosaccharides, 31-32 parts of sodium caseinate, 3-5 parts of mono- and diglycerol fatty acid esters, 0.2-0.4 parts of vitamin E, 8-9 parts of sodium tripolyphosphate, 0.03-0.05 parts of ascorbyl palmitate, and 3-4 parts of sodium ascorbate;

[0010] The carbohydrates consist of 420-598 parts maltodextrin and 172-212 parts corn syrup solids.

[0011] Furthermore, the dietary fiber substance is composed of 18-33 parts of galacto-oligosaccharides and 25-42 parts of fructo-oligosaccharides.

[0012] Furthermore, the composite trace minerals are composed of 0.03-0.04 parts of copper sulfate, 0.62-0.81 parts of ferric pyrophosphate, 0.07-0.08 parts of manganese sulfate, 0.0012-0.0023 parts of sodium selenite, 0.25-0.32 parts of zinc citrate, 0.0019-0.0028 parts of potassium iodide and 3-4 parts of edible carriers.

[0013] Furthermore, the complex macrominerals are composed of 10.9-14.6 parts of tricalcium phosphate, 12.5-19.2 parts of calcium carbonate, 3.2-7.6 parts of magnesium carbonate, 15.1-17.6 parts of potassium chloride, 18.9-21.4 parts of potassium citrate, 32.1-32.6 parts of sodium citrate and 7-12 parts of edible carriers.

[0014] Furthermore, the multivitamin is composed of 2.68-3.00 parts of sodium L-ascorbate, 0.62-0.76 parts of vitamin E, 0.19-0.3 parts of nicotinamide, 0.1-0.2 parts of calcium D-pantothenate, 0.03-0.04 parts of pyridoxine hydrochloride, 0.04-0.06 parts of thiamine hydrochloride, 0.02-0.03 parts of vitamin A palmitate, 0.03-0.05 parts of riboflavin, 0.004-0.006 parts of folic acid, 0.001-0.003 parts of phytonadione, 0.0003-0.0004 parts of D-biotin, 0.0001-0.0003 parts of cholecalciferol, 0.00006-0.00007 parts of cyanocobalamin and 6-9 parts of edible carriers.

[0015] Furthermore, the edible carrier is maltodextrin.

[0016] Furthermore, it is prepared from the following raw materials in the following weight ratio:

[0017] 295 parts of protein, 395 parts of fat, 770 parts of carbohydrates, 58 parts of dietary fiber, 4.7 parts of complex trace minerals, 119 parts of complex macrominerals, 10.7 parts of complex vitamins, 7.62 parts of choline bitartrate, 0.986 parts of L-carnitine, and 0.762 parts of taurine;

[0018] The protein material is composed of 37 parts of whey protein, 96 parts of soy protein and 162 parts of casein;

[0019] The fatty substance is a vegetable oil microcapsule powder made from 71 parts of medium-chain triglycerides, 62 parts of sunflower oil, 57 parts of soybean oil, 88 parts of low-erucic acid rapeseed oil, and 117 parts of an edible carrier; the edible carrier is composed of 69.16 parts of maltooligosaccharides, 32 parts of sodium caseinate, 4 parts of mono- and diglycerol fatty acid esters, 0.3 parts of vitamin E, 8.3 parts of sodium tripolyphosphate, 0.04 parts of ascorbyl palmitate, and 3.2 parts of sodium ascorbate;

[0020] The carbohydrates consist of 598 parts maltodextrin and 172 parts corn syrup solids.

[0021] The dietary fiber substance is composed of 33 parts of galacto-oligosaccharides and 25 parts of fructo-oligosaccharides;

[0022] The complex trace minerals are composed of 0.04 parts of copper sulfate, 0.62 parts of ferric pyrophosphate, 0.08 parts of manganese sulfate, 0.0012 parts of sodium selenite, 0.32 parts of zinc citrate, 0.0028 parts of potassium iodide and 3.636 parts of maltodextrin;

[0023] The complex macro minerals are composed of 14.6 parts of tricalcium phosphate, 19.2 parts of calcium carbonate, 7.6 parts of magnesium carbonate, 15.1 parts of potassium chloride, 18.9 parts of potassium citrate, 32.1 parts of sodium citrate and 11.5 parts of maltodextrin.

[0024] The multivitamin consists of 2.68 parts of sodium L-ascorbate, 0.624 parts of vitamin E, 0.196 parts of niacinamide, 0.12 parts of calcium D-pantothenate, 0.0336 parts of pyridoxine hydrochloride, 0.046 parts of thiamine hydrochloride, 0.02 parts of vitamin A palmitate, 0.035 parts of riboflavin, 0.0057 parts of folic acid, 0.0015 parts of phytonadione, 0.0003 parts of D-biotin, 0.0002 parts of cholecalciferol, 0.00007 parts of cyanocobalamin and 6.93763 parts of maltodextrin.

[0025] Furthermore, it is prepared from the following raw materials in the following weight ratio:

[0026] 257 parts of protein, 383 parts of fat, 632 parts of carbohydrates, 60 parts of dietary fiber, 5.1 parts of complex trace minerals, 106 parts of complex macrominerals, 12.9 parts of complex vitamins, 6.21 parts of choline bitartrate, 1.1 parts of L-carnitine, and 0.42 parts of taurine;

[0027] The protein material is composed of 47 parts of whey protein, 112 parts of soy protein and 98 parts of casein;

[0028] The fatty substance is a vegetable oil microcapsule powder made from 66 parts of medium-chain triglycerides, 79 parts of sunflower oil, 51 parts of soybean oil, 72 parts of low-erucic acid rapeseed oil, and 115 parts of an edible carrier; the edible carrier is composed of 68.66 parts of maltooligosaccharides, 31 parts of sodium caseinate, 4 parts of mono- and diglycerol fatty acid esters, 0.3 parts of vitamin E, 8.3 parts of sodium tripolyphosphate, 0.04 parts of ascorbyl palmitate, and 3 parts of sodium ascorbate;

[0029] The carbohydrates are composed of 420 parts of maltodextrin and 212 parts of solid corn syrup;

[0030] The dietary fiber substance is composed of 18 parts of galacto-oligosaccharides and 42 parts of fructo-oligosaccharides;

[0031] The complex trace minerals are composed of 0.03 parts of copper sulfate, 0.81 parts of ferric pyrophosphate, 0.07 parts of manganese sulfate, 0.0023 parts of sodium selenite, 0.25 parts of zinc citrate, 0.0019 parts of potassium iodide and 3.636 parts of maltodextrin;

[0032] The complex macro minerals are composed of 10.9 parts of tricalcium phosphate, 12.5 parts of calcium carbonate, 3.2 parts of magnesium carbonate, 17.6 parts of potassium chloride, 21.4 parts of potassium citrate, 32.6 parts of sodium citrate and 7.8 parts of maltodextrin.

[0033] The multivitamin consists of 3 parts of sodium L-ascorbate, 0.76 parts of vitamin E, 0.28 parts of niacinamide, 0.12 parts of calcium D-pantothenate, 0.03 parts of pyridoxine hydrochloride, 0.05 parts of thiamine hydrochloride, 0.03 parts of vitamin A palmitate, 0.04 parts of riboflavin, 0.0042 parts of folic acid, 0.002 parts of phytonadione, 0.0004 parts of D-biotin, 0.0001 parts of cholecalciferol, 0.00006 parts of cyanocobalamin and 8.58324 parts of maltodextrin.

[0034] The present invention also provides a method for preparing the aforementioned nutritional composition, comprising the following steps:

[0035] 1) weighing the raw materials according to the ratio;

[0036] 2) Mix choline bitartrate, L-carnitine, taurine, complex vitamins, and complex trace minerals, and stir at 20-30 rpm for 10-20 min to obtain premix 1; mix dietary fiber and whey protein, and stir at 20-30 rpm for 10-20 min to obtain premix 2; mix complex macrominerals and soy protein, and stir at 20-30 rpm for 10-20 min to obtain premix 3;

[0037] 3) Premix 1, premix 2, and premix 3 obtained in step 2) are mixed and stirred at 20-30 rpm for 20-30 min to obtain a total mixture 1; solid corn syrup and casein are mixed with the total mixture 1 and stirred at 20-30 rpm for 30-60 min to obtain a total mixture 2; and fatty substances and maltodextrin are mixed with the total mixture 2 and stirred at 20-30 rpm for 40-60 min to obtain.

[0038] Finally, the present invention provides a nutritional composition for use in preparing food or medicine for enhancing immunity, strengthening bones and / or improving constipation.

[0039] Furthermore, the food or medicine has the effects of enhancing immunity, increasing bone density and / or relieving constipation.

[0040] Unless otherwise specified, the "parts" described in the present invention are parts by mass.

[0041] In the nutritional composition of the present invention, soy protein, whey protein and casein provide a variety of high-quality proteins with rich amino acid content and appropriate ratio, which are conducive to the body's absorption and utilization of protein; carbohydrates are provided by solid corn syrup and maltodextrin, which have good solubility and are easily digested and absorbed by the human body; fat comes from low-erucic acid rapeseed oil, sunflower oil, medium-chain triglycerides and soybean oil, which meet the body's demand for essential fatty acids; dietary fiber comes from oligosaccharides and oligofructose, which helps improve intestinal function; choline bitartrate is added to promote body fat metabolism and lower serum cholesterol; L-carnitine acts as a carrier of fatty acid metabolism, promoting the oxidation of fatty acids; taurine is added to enhance the body's immunity and anti-fatigue functions; sodium L-ascorbate, vitamin E, niacinamide, pyridoxine hydrochloride, D-calcium pantothenate, thiamine hydrochloride, vitamin A palmitate, riboflavin, folic acid, phytonadione, D-biotin, cholecalciferol, and cyanocobalamin are added to provide the vitamins needed by the body; copper sulfate, ferric pyrophosphate, manganese sulfate, sodium selenite, zinc citrate, potassium iodide, tricalcium phosphate, magnesium carbonate, calcium carbonate, potassium chloride, potassium citrate, and sodium citrate are added to provide the minerals needed by the body.

[0042] Through extensive experimental research, the inventors have found that the nutritional composition obtained according to the formula of the present invention can significantly improve the health of people with low immunity, enhance immunity, maintain bone health, and provide effective nutritional support for the recovery of clinical patients. Whey protein contains multiple essential amino acids for the human body in a reasonable ratio and is easy to digest and absorb. The bioactive ingredients it contains help improve immunity and restore physical fitness; casein can continuously provide the human body with slowly released protein for a long time, maintaining a sense of fullness, and can also promote the efficient absorption of macroelements and trace elements; soy protein is a complete plant protein rich in multiple essential amino acids required by the human body, easy to digest and absorb, and has high nutritional value; the mixed use of multiple proteins can achieve a good ratio of amino acids, which helps to improve the bioavailability of protein. Vitamin A plays an important role in maintaining the normal function of the immune system; vitamin E, as an important antioxidant, can protect the body's cells from damage by free radicals and delay cell aging; B vitamins, as essential nutrients for amino acid metabolism and fat metabolism in the body, participate in tissue repair and cell regeneration, promote human metabolism, regulate immune function, and enhance resistance to pathogens; vitamin C plays an important role in anti-oxidation, promoting collagen synthesis, lowering cholesterol, and participating in the body's detoxification. It helps to reduce the harm caused by drugs and environmental pollution to the human body, and can also participate in the metabolism of protein, collagen aminopolysaccharides in bone tissue, which is beneficial to calcium absorption and deposition in bones; vitamin D is beneficial to regulating bone calcium absorption and promoting bone formation. The added mineral zinc participates in the synthesis and activation of various enzymes in the body and contributes to immune function. Iron, a crucial component of hemoglobin, plays a key role in maintaining normal hematopoiesis and is a key component of many enzymes and immune system compounds, boosting immunity and increasing resistance to disease. Selenium not only boosts immunity and maintains the normal function of vital organs such as the heart, liver, lungs, and stomach, but also protects and repairs cells and enhances the body's antioxidant capacity. Calcium maintains the physical strength of the human skeleton and is essential for maintaining bone health. L-carnitine, a key substance involved in fat metabolism, promotes fat conversion, increases fat utilization, reduces fat accumulation, and effectively regulates intracellular energy metabolism. Choline helps maintain cell membrane integrity, improves fat absorption and utilization, and protects the liver. Taurine plays an important role in regulating nerve conduction, lipid digestion and absorption, and boosting immunity, making it a key active substance in regulating normal physiological activities. Adding galacto-oligosaccharides and fructo-oligosaccharides acts as dietary fiber, maintaining intestinal immune function and preventing and relieving constipation symptoms.

[0043] The nutritional composition for enhancing immunity and strengthening bones of the present invention comprehensively supplements the nutrients required by the body for people with low immunity through specific ingredients and dosage ratios, so as to regulate body functions and enhance immunity. At the same time, it can also strengthen bones and improve constipation, promote the recovery of body functions, and improve the quality of life. It is a nutritionally comprehensive and reasonably matched nutritional composition with practical promotion value.

[0044] Obviously, based on the above contents of the present invention, according to common technical knowledge and customary means in this field, without departing from the above basic technical ideas of the present invention, other various forms of modifications, replacements or changes can be made.

[0045] The following further describes the above content of the present invention in detail through specific embodiments in the form of examples. However, this should not be construed as limiting the scope of the above subject matter of the present invention to the following examples. All technologies implemented based on the above content of the present invention fall within the scope of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1. Changes in mouse body weight;

[0047] Figure 2 Effects of the nutritional composition on immunosuppressed mice (A: Effect on body weight, B: Effect on food intake; * indicates P < 0.05 compared with the model group)

[0048] Figure 3 Effects of the nutritional composition on serum TNF-α, IgG, and IgM concentrations in mice (A: TNF-α concentration, B: IgG concentration, C: IgM concentration, * indicates P < 0.05 compared with the model group)

[0049] Figure 4 Effects of the nutritional composition on the frequency of defecation and number of fecal pellets in mice (A: frequency of defecation, B: number of fecal pellets, * indicates P < 0.05 compared with the model group) DETAILED DESCRIPTION

[0050] The raw materials and equipment in the specific embodiment of the present invention can be purchased commercially, wherein low-erucic acid rapeseed oil is rapeseed oil with an erucic acid content of no more than 3% of the fatty acid composition; oligomaltodextrose is an oligosaccharide composed of more than 3 but less than 10 glucose groups connected by α-1,4 glycosidic bonds.

[0051] Example 1 Preparation of the nutritional composition of the present invention

[0052] Formula: 295 parts of protein: 37 parts of whey protein, 96 parts of soy protein, 162 parts of casein;

[0053] 395 parts of vegetable oil microcapsule powder: prepared by mixing 71 parts of medium-chain triglycerides, 62 parts of sunflower oil, 57 parts of soybean oil, 88 parts of low-erucic acid rapeseed oil, and the remainder of the edible carrier 69.16 parts of maltooligosaccharides, 32 parts of sodium caseinate, 4 parts of mono- and diglycerides of fatty acids, 0.3 parts of vitamin E, 8.3 parts of sodium tripolyphosphate, 0.04 parts of ascorbyl palmitate, and 3.2 parts of sodium ascorbate;

[0054] 770 parts of carbohydrates: 598 parts of maltodextrin and 172 parts of corn syrup solids;

[0055] Dietary fiber 58 parts: It is made by mixing 33 parts of galacto-oligosaccharide and 25 parts of fructo-oligosaccharide;

[0056] 10.7 parts of multivitamin: prepared by mixing 2.68 parts of sodium L-ascorbate, 0.624 parts of vitamin E, 0.196 parts of niacinamide, 0.12 parts of calcium D-pantothenate, 0.0336 parts of pyridoxine hydrochloride, 0.046 parts of thiamine hydrochloride, 0.02 parts of vitamin A palmitate, 0.035 parts of riboflavin, 0.0057 parts of folic acid, 0.0015 parts of phytonadione, 0.0003 parts of D-biotin, 0.0002 parts of cholecalciferol, 0.00007 parts of cyanocobalamin, and the balance as a multivitamin carrier maltodextrin;

[0057] 4.7 parts of composite trace minerals: 0.04 parts of copper sulfate, 0.62 parts of ferric pyrophosphate, 0.08 parts of manganese sulfate, 0.0012 parts of sodium selenite, 0.32 parts of zinc citrate, 0.0028 parts of potassium iodide, and the balance is maltodextrin, a composite trace mineral carrier;

[0058] 119 parts of complex macrominerals: It is made by mixing 14.6 parts of tricalcium phosphate, 19.2 parts of calcium carbonate, 7.6 parts of magnesium carbonate, 15.1 parts of potassium chloride, 18.9 parts of potassium citrate, 32.1 parts of sodium citrate, and the balance is maltodextrin, a carrier of complex macrominerals;

[0059] 7.62 parts of choline bitartrate; 0.986 parts of L-carnitine; and 0.762 parts of taurine.

[0060] Preparation method:

[0061] (1) Accurately weigh the raw materials and divide them into 5 groups according to the order of mass ratio from low to high;

[0062] Raw material group 1: choline bitartrate, L-carnitine, taurine, multivitamins, and multi-trace minerals;

[0063] Raw material group 2: dietary fiber, whey protein;

[0064] Raw material group 3: complex macro minerals, soy protein;

[0065] Raw material group 4: corn syrup solids, casein;

[0066] Raw material group 5: vegetable oil microcapsule powder, maltodextrin.

[0067] (2) Premixing of raw materials with lower addition amount

[0068] Premix 1: Transfer raw material group 1 to a premixer at 25 rpm and mix for 15 min to obtain premix 1;

[0069] Premix 2: Take out premix 1 and transfer raw material group 2 to the premixer at a speed of 25 rpm and mix for 15 minutes to obtain premix 2;

[0070] Premix 3: Take out premix 2 and transfer raw material group 3 to the premixer at a speed of 25 rpm and mix for 15 minutes to obtain premix 3.

[0071] (3) Total Mixing

[0072] Total blend 1: transfer premixes 1, 2, and 3 to a total mixer at a speed of 30 rpm and mix for 30 min to obtain total blend 1;

[0073] Total blend 2: Transfer raw material group 4 to the total mixer and mix with total blend 1 at a speed of 30 rpm for 40 min to obtain total blend 2;

[0074] Total blend 3: Transfer raw material group 5 to the total mixer and mix it with total blend 2 at a speed of 30 rpm for 60 min to obtain the finished product.

[0075] (4) Repackaging and packaging

[0076] The mixed finished product is divided and packaged under sterile conditions. The above operation steps are all carried out in a clean and dry environment.

[0077] Example 2 Preparation of the nutritional composition of the present invention

[0078] Formula: 257 parts of protein: 47 parts of whey protein, 112 parts of soy protein, 98 parts of casein;

[0079] 383 parts of vegetable oil microcapsule powder: prepared by mixing 66 parts of medium-chain triglycerides, 79 parts of sunflower oil, 51 parts of soybean oil, 72 parts of rapeseed oil, and the remainder of the edible carrier 68.66 parts of maltooligosaccharides, 31 parts of sodium caseinate, 4 parts of mono- and diglycerides of fatty acids, 0.3 parts of vitamin E, 8 parts of sodium tripolyphosphate, 0.04 parts of ascorbyl palmitate, and 3 parts of sodium ascorbate;

[0080] 632 parts of carbohydrates: 420 parts of maltodextrin and 212 parts of corn syrup solids;

[0081] Dietary fiber 60 parts: It is made by mixing 18 parts of galacto-oligosaccharide and 42 parts of fructo-oligosaccharide;

[0082] 12.9 parts of multivitamin: prepared by mixing 3 parts of sodium L-ascorbate, 0.76 parts of vitamin E, 0.28 parts of niacinamide, 0.12 parts of calcium D-pantothenate, 0.03 parts of pyridoxine hydrochloride, 0.05 parts of thiamine hydrochloride, 0.03 parts of vitamin A palmitate, 0.04 parts of riboflavin, 0.0042 parts of folic acid, 0.002 parts of phytonadione, 0.0004 parts of D-biotin, 0.0001 parts of cholecalciferol, 0.00006 parts of cyanocobalamin, and the balance as a multivitamin carrier maltodextrin;

[0083] 5.1 parts of composite trace minerals: 0.03 parts of copper sulfate, 0.81 parts of ferric pyrophosphate, 0.07 parts of manganese sulfate, 0.0023 parts of sodium selenite, 0.25 parts of zinc citrate, 0.0019 parts of potassium iodide, and the balance is maltodextrin, a composite trace mineral carrier;

[0084] 106 parts of complex macrominerals: It is made by mixing 10.9 parts of tricalcium phosphate, 12.5 parts of calcium carbonate, 3.2 parts of magnesium carbonate, 17.6 parts of potassium chloride, 21.4 parts of potassium citrate, 32.6 parts of sodium citrate, and the balance is maltodextrin, a carrier of complex macrominerals;

[0085] 6.21 parts of choline bitartrate; 1.1 parts of L-carnitine; 0.42 parts of taurine.

[0086] Preparation method:

[0087] (1) Accurately weigh the raw materials and divide them into 5 groups according to the order of mass ratio from low to high;

[0088] Raw material group 1: choline bitartrate, L-carnitine, taurine, multivitamins, and multi-trace minerals;

[0089] Raw material group 2: dietary fiber, whey protein;

[0090] Raw material group 3: complex macro minerals, soy protein;

[0091] Raw material group 4: corn syrup solids, casein;

[0092] Raw material group 5: vegetable oil microcapsule powder, maltodextrin.

[0093] (2) Premixing of raw materials with lower addition amount

[0094] Premix 1: Transfer raw material group 1 to a premixer at a speed of 30 rpm and mix for 20 min to obtain premix 1;

[0095] Premix 2: Take out premix 1 and transfer raw material group 2 to the premixer at a speed of 30 rpm and mix for 20 min to obtain premix 2;

[0096] Premix 3: Take out premix 2 and transfer raw material group 3 to a premixer at a speed of 30 rpm and mix for 20 min to obtain premix 3.

[0097] (3) Total Mixing

[0098] Total blend 1: transfer premixes 1, 2, and 3 to a total mixer at a speed of 30 rpm and mix for 30 min to obtain total blend 1;

[0099] Total blend 2: Transfer raw material group 4 to the total mixer and mix with total blend 1 at a speed of 30 rpm for 60 min to obtain total blend 2;

[0100] Total blend 3: Transfer raw material group 5 to the total mixer and mix it with total blend 2 at a speed of 30 rpm for 60 min to obtain the finished product.

[0101] (4) Repackaging and packaging

[0102] The mixed finished product is divided and packaged under sterile conditions. The above operation steps are all carried out in a clean and dry environment.

[0103] Comparative Example 3

[0104] Other conditions and steps are the same as those in Example 1, except that the amount of casein in the protein is adjusted to 40 parts, and the total amount of protein substances changes accordingly; the amount of vegetable oil microcapsule powder is adjusted to 220 parts (comprising 27 parts of medium-chain triglycerides, 32 parts of sunflower oil, 48 parts of soybean oil, 47 parts of low-erucic acid rapeseed oil, and the rest are 33 parts of edible carrier oligomaltose, 16 parts of sodium caseinate, 2.5 parts of mono- and diglycerol fatty acid esters, 3.3 parts of sodium tripolyphosphate, and no vitamin E, ascorbyl palmitate, and sodium ascorbate are added); tricalcium phosphate is omitted from the complex macro minerals, the amount of calcium carbonate is adjusted to 2.1 parts, and the total amount of complex macro minerals changes accordingly.

[0105] Comparative Example 4

[0106] Other conditions and steps were the same as those in Example 1, except that the amount of whey protein in the protein was adjusted to 12 parts, the amount of casein was adjusted to 40 parts, and the total amount of protein substances changed accordingly; taurine was omitted; the amount of vitamin E in the edible carrier of the vegetable oil microcapsule powder was adjusted to 0.02 parts, the amount of ascorbyl palmitate was adjusted to 0.01 parts, and sodium ascorbate was omitted, and the total amount of the vegetable oil microcapsule powder changed accordingly; the amount of cholecalciferol in the multivitamin was adjusted to 0.00003 parts, and the total amount of the multivitamin changed accordingly.

[0107] Comparative Example 5

[0108] Other conditions and steps are the same as those in Example 2, except that whey protein is omitted from the protein, the amount of casein is adjusted to 88 parts, the amount of soy protein is adjusted to 131 parts, the amount of taurine is adjusted to 0.02 parts, and the total amount of protein substances changes accordingly; vitamin E is omitted from the edible carrier of the vegetable oil microcapsule powder, the amount of ascorbyl palmitate is adjusted to 0.008 parts, and the amount of sodium ascorbate is adjusted to 0.2 parts, and the total amount of the vegetable oil microcapsule powder changes accordingly; the amount of tricalcium phosphate in the complex macrominerals is adjusted to 1.6 parts; and oligofructose is omitted from the dietary fiber, and the total amount of the complex macrominerals changes accordingly.

[0109] Comparative Example 6

[0110] Other conditions and steps are the same as those in Example 2, except that the amount of whey protein in the protein is adjusted to 61 parts, and the total amount of protein substances changes accordingly; taurine is omitted; vitamin E and ascorbyl palmitate are omitted from the edible carrier of the vegetable oil microcapsule powder, the amount of sodium ascorbate is adjusted to 0.7 parts, and the total amount of the vegetable oil microcapsule powder changes accordingly; the amount of galacto-oligosaccharide in the dietary fiber is adjusted to 2 parts, the amount of fructo-oligosaccharide is adjusted to 3 parts, and the total amount of dietary fiber changes accordingly.

[0111] The beneficial effects of the present invention are further illustrated by the following test examples:

[0112] Test Example 1 Performance test of the nutritional composition of the present invention

[0113] 1. Stability test

[0114] The nutritional compositions prepared in Examples 1-2 and Comparative Examples 3-6 were stored at a temperature of 40±2°C and a relative humidity of 75±5% for 3 months. Samples were taken at the beginning of the experiment, and at the end of the first, second, and third months of the experiment. The peroxide values ​​were measured by titration. The results are shown in Table 1.

[0115] Table 1 Accelerated stability test results

[0116] The above stability test results show that under the conditions of temperature 40±2°C and humidity 75±5%, the composition prepared outside the preferred range, i.e., Examples 1-2, showed a rapid increase in oxidation value over time, approaching or exceeding 10 meq / kg at 3 months, indicating a certain stability risk. However, the nutritional composition containing mixed tocopherol concentrate, sodium ascorbate, and ascorbyl palmitate simultaneously, in amounts within the preferred range, i.e., Examples 1-2, showed the best antioxidant effect and optimal stability.

[0117] 2. Antioxidant Activity Test

[0118] The nutritional compositions prepared in Examples 1 to 2 and Comparative Examples 3 to 6 were tested for DPPH radical scavenging rate, hydroxyl radical scavenging rate, and superoxide anion radical scavenging rate of the nutritional compositions using the DPPH radical scavenging method, salicylic acid method, and pyrogallol autooxidation method, respectively, to evaluate the antioxidant activity of the nutritional compositions. The results are shown in Table 2.

[0119] Table 2 Antioxidant activity test of each example

[0120] DPPH is a relatively stable nitrogen-containing organic free radical and is a common indicator for measuring the antioxidant capacity of a sample; hydroxyl radicals are the most harmful free radicals, and the ability to scavenge hydroxyl radicals is a good proof of antioxidant capacity; superoxide anion radicals can easily induce lipid peroxidation reactions in organisms. As shown in Table 2, the DPPH radical scavenging rates of Example 1 and Example 2 were 92.29% and 89.57%, respectively, the hydroxyl radical scavenging rates were 62.14% and 60.25%, respectively, and the superoxide anion radical scavenging rates were 70.12% and 71.56%, respectively, which were much higher than those of other examples. This shows that Example 1 and Example 2 have better antioxidant capacity, and also shows that the antioxidant capacity of the nutritional compositions in Example 1 and Example 2 has a synergistic effect.

[0121] 3. Toxicity Test

[0122] The acute toxicity of the nutritional compositions prepared in Examples 1 to 2 and Comparative Examples 3 to 6 was tested on normal mice.

[0123] 35 male 4-week-old SPF Kunming mice weighing 20±2g were selected. The mice were subjected to a 3-day adaptive feeding before the formal experiment. During the experiment, the ambient temperature was set at 25±1°C, the humidity was 40%±10%, the light duration was 12h, and the dark duration was 12h. The experimental mice were divided into 7 groups, a blank control group, groups 1 to 2 of Examples, and groups 3 to 6 of Comparative Examples, for acute toxicity tests. The mice were randomly divided into 7 cages according to their body weight, with 5 mice in each cage. The experimental group was gavaged with the nutritional composition obtained from Examples 1 to 2 and Comparative Examples 3 to 6 at a maximum gavage dose of 5g / (kg·d), and the blank control group was gavaged with the same dose of normal saline. The mice in each group were free to eat except for gavage. After gavage, the changes in the appearance, behavior, secretions, etc. of the mice were observed every day for 14 consecutive days. The animals were weighed every other day. During the experiment, animals that died or were dying moderately were immediately autopsied. The surviving animals were killed and autopsied after the gavage.

[0124] Detection indicators: 1. Changes in mouse body weight; 2. Acute damage to mouse tissues and organs. The results are shown in Figure 1 and Table 3.

[0125] Table 3 Mouse organ test results

[0126] As can be seen from Figure 1, the weight of mice in the blank control group, Example 1-2 groups, and Comparative Example 3-6 groups all showed a normal growth trend, and after the start of gavage, the weight gain of the mice in each group of Examples was always higher than that in the control group, indicating that Examples 1-2 and Comparative Examples 3-6 can promote the weight gain of mice without affecting the normal development of mice.

[0127] After two weeks of oral feeding, the results of post-anatomy examination showed that compared with the blank control group, the texture and color of the organs of the mice in each example group were normal, indicating that the test substances in Examples 1 to 2 and Comparative Examples 3 to 6 had no visible damage to the mouse organs and no acute toxic damage.

[0128] IV. Immune Effect Test

[0129] The nutritional compositions prepared in Examples 1 to 2 and Comparative Examples 3 to 6 were used to test the immune response of immunodeficient mice.

[0130] 40 SPF grade Kunming male mice aged 4 weeks, weighing 20±2g were selected. The mice were subjected to adaptive feeding for 3 days before the formal experiment. During the experiment, the ambient temperature was set at 25±1°C, the humidity was 40%±10%, the light duration was 12h, and the dark duration was 12h. The experimental mice were randomly divided into 8 cages according to their weight, with 5 mice in each cage, and divided into blank control group, model group and Example 1-6 group, a total of 8 groups for immune response test. Example 1-2 group and Comparative Example 3-6 group were gavaged with 500mg / (kg·d) of Example 1-2 and Comparative Example 3-6 suspension, and the blank control group and model group were gavaged with the same dose of normal saline. Starting from the 9th day, except for the blank control group, the remaining groups of mice were intraperitoneally injected with 80mg / (kg·d) cyclophosphamide (CTX) solution to establish an immunosuppression model for three consecutive days, during which gavage was maintained. The intraperitoneal injection of CTX was stopped on the 12th day of the experiment, and feeding was continued until the 15th day. Weigh and record the body weight before gavage. The average food intake of each group was calculated by weighing the feed daily. Three mice were fasted but not watered until the end of the experiment. Mice were sacrificed by removing their eyes, drawing blood, and dislocating their cervix. The thymus, spleen, liver, and kidneys were dissected and weighed for their wet weight.

[0131] Detection indicators: 1. Changes in mouse body weight; 2. Changes in mouse food intake; 3. Mouse organ index; 4. Mouse serum immune factor and immunoglobulin levels. The results are shown in Figure 2, Table 4 and Figure 3.

[0132] As shown in Figure 2A and Figure 2B, within the first 8 days, each group of mice maintained the state of eating and gaining weight, and there was no significant difference in the amount of food intake and body weight of each group of mice. CTX was used to set up an immunosuppressed mouse model on the 9th day, and for 3 consecutive days, except for the blank control group, the body weight of the remaining mice in each group was all declining, and the free food intake was significantly reduced, indicating that modeling was successful. After stopping modeling from the 12th day, except for the model group, the body weight of each group of mice was recovered, but the blank group body weight level could not be reached. Compared with the model group, embodiment 1 and embodiment 2 two groups of mice body weight significantly increased (P < 0.05) from the 12th day to the 15th day, and embodiment 1-2 group of mice food intake gradually returned to the level before modeling. During 12-15 days, although comparative example 3, comparative example 5 and comparative example 6 group of mice body weight and food intake all increased, there was no statistically significant difference (P > 0.05) compared with model group mice, and from the 9th-15th day comparative example 4 group of mice body weight and food intake all showed a downward trend. Therefore, the experimental results show that the weight of mice in each group showed an increasing trend from day 1 to day 8 of the experiment. During the modeling period from day 9 to day 11, because CTX suppresses the immune system, it also affects other physiological activities of mice, such as reduced food intake and hindered growth performance. After intervention with Example 1 to 2 groups and Comparative Examples 3 to 6, Example 1-2 can effectively maintain the weight and food intake of mice. This shows that Example 1 and Example 2 help to restore the weight of immunocompromised mice, while Comparative Examples 3-6 do not significantly improve the weight loss and food intake of immunocompromised mice.

[0133] Table 4 Effects of nutritional composition on organ indexes of immunocompromised mice Note: a means P < 0.05 compared with the model group

[0134] As shown in Table 4, there were no significant differences in the liver and kidney indices between the groups of mice. However, as the main immune organs, the spleen and thymus indices of the blank group, Example 1, and Example 2 were significantly higher than those of the model group (P < 0.05), indicating that Examples 1 and 2 helped to restore the immune organs of mice, thereby improving immunity. Compared with the model group, there were no significant differences in the spleen and kidney indices of the mice in the comparative example groups 3-6 (P > 0.05). The experimental results show that Examples 1 and 2 can significantly improve the recovery of the immune organs of immunocompromised mice.

[0135] TNF-α is an important inflammatory cytokine that has important physiological functions such as regulating multiple immune and inflammatory responses and helping the body to resist infection with pathogens. IgG and IgM are major immunoglobulins with multiple immunoregulatory functions. As shown in Figure 3A, compared with the model group, the serum TNF-α concentration of mice in the blank control group, Example 1 and Example 2 groups significantly increased (P < 0.05). As shown in Figure 3B and Figure 3C, compared with the model group, the serum IgG and IgM concentrations of mice in the blank control group, Example 1 and Example 2 groups significantly increased (P < 0.05). The experimental results show that Example 1 and Example 2 can significantly improve the content of serum immune factor TNF-α and immunoglobulin IgG, IgM, thereby achieving the effect of enhancing the body's immune capacity.

[0136] 5. Calcium absorption test

[0137] The effects of the nutritional compositions prepared in Examples 1 to 2 and Comparative Examples 3 to 6 on promoting calcium absorption in immunodeficient mice were tested in the following steps:

[0138] The feeding and intervention methods of mice were the same as those in “IV. Immune Effect Test”. After the intervention, blood was collected from the eyeballs of three mice in each group, and the serum 25-hydroxyvitamin D osteocalcin levels of mice in each group were detected using an enzyme-linked immunosorbent assay kit. The results are shown in Table 5.

[0139] Table 5 Effects of nutritional composition on serum 25-hydroxyvitamin D and osteocalcin levels in mice Note: a means P < 0.05 compared with the model group

[0140] The main function of vitamin D is to regulate calcium and phosphorus metabolism in the body, reducing the risk of osteoporosis and fractures. 25-hydroxyvitamin D is a reliable indicator of vitamin D levels in the body. Osteocalcin is a non-collagenous protein produced and secreted by osteoblasts. As an indicator of bone metabolism, it can directly reflect bone cell activity.

[0141] As shown in Table 5, compared with the model group, the serum 25-hydroxyvitamin D and osteocalcin levels of the mice in the blank group, Example 1 and Example 2 groups were significantly increased (P < 0.05), indicating that Example 1 and Example 2 can promote calcium absorption, increase osteocalcin levels, increase bone density, promote bone health, and strengthen bones.

[0142] 6. Defecation-promoting effect test

[0143] The defecation promoting effect of the nutritional compositions prepared in Examples 1 to 2 and Comparative Examples 3 to 6 on immunodeficient mice was tested, and the steps were as follows:

[0144] The mice were fed and treated as described in "IV. Immune Effect Testing." After the intervention, five mice from each group were placed in metabolic cages. The number of defecations was counted over a 4-hour period. Feces were collected and the number of fecal pellets was counted. The results are shown in Figure 4.

[0145] Low immunity can lead to slow intestinal motility and delayed intestinal excretion, seriously affecting quality of life. The nutritional composition improves small intestinal transit efficiency and promotes intestinal motility. The effectiveness of the nutritional composition in promoting bowel movements was evaluated by observing the frequency of bowel movements and the number of fecal particles in mice over a 4-hour period.

[0146] As shown in Figure 4A, compared with the model group, the number of defecation times within 4 hours in the blank control group, Example 1, and Implementation 2 groups of mice significantly increased (P < 0.05); as shown in Figure 4B, compared with the model group, the number of fecal particles in the blank control group, Example 1, and Implementation 2 groups of mice significantly increased (P < 0.05). The experimental results show that Examples 1 and 2 can significantly improve the small intestinal transit efficiency of mice, increase the frequency of defecation in mice, and improve the constipation condition of mice.

[0147] The above experimental results show that, by the maximum tolerated dose method, the mice were gavaged with the nutritional compositions obtained in Examples 1 to 2 and Comparative Examples 3 to 6 at the maximum gavage dose, and the weight and internal organs of the mice were observed. It was verified that Examples 1 to 2 and Comparative Examples 3 to 6 were safe and non-toxic, with no visible damage to the organs, and would not affect the normal growth and development of the mice. The immune response experiment verified that Example 1-2 can significantly improve the immunosuppressive effect induced by CTX, help to slow down the weight loss and reduced food intake induced by immunosuppression, and accelerate the recovery of damaged immune organs such as the spleen and thymus. At the same time, Example 1-2 has the effect of promoting calcium absorption in the body, increasing osteocalcin concentration, increasing bone density, and strengthening bones. In addition, Example 1-2 can also increase the frequency of bowel movements in mice and improve constipation in mice.

[0148] In summary, the nutritional composition of the present invention has the effects of enhancing immunity, increasing bone density, and relieving constipation. It can comprehensively supplement the nutrients required by the body for people with low immunity, so as to achieve the purpose of enhancing immunity, strengthening bones, improving constipation, promoting the body to restore normal functions, and improving the quality of life.

Claims

1. A nutritional composition for enhancing immunity, strengthening bones and / or improving constipation, characterized in that: It is composed of the following raw materials in weight ratio: 257-295 parts of protein, 383-395 parts of fat, 632-770 parts of carbohydrates, 58-60 parts of dietary fiber, 4.7-5.1 parts of complex trace minerals, 106-119 parts of complex macro minerals, 10.7-12.9 parts of complex vitamins, 6.21-7.62 parts of choline bitartrate, 0.986-1.1 parts of L-carnitine, 0.42-0.762 parts of taurine; The protein material is composed of 37-47 parts of whey protein, 96-112 parts of soy protein and 98-162 parts of casein; The fat substance is a vegetable oil microcapsule powder made from 66-71 parts of medium-chain triglycerides, 62-79 parts of sunflower oil, 51-57 parts of soybean oil, 72-88 parts of low-erucic acid rapeseed oil and 115-117 parts of an edible carrier; the edible carrier is composed of 68-70 parts of maltooligosaccharides, 31-32 parts of sodium caseinate, 3-5 parts of mono- and di-glycerol fatty acid esters, 0.2-0.4 parts of vitamin E, 8-9 parts of sodium tripolyphosphate, 0.03-0.05 parts of ascorbyl palmitate and 3-4 parts of sodium ascorbate; The carbohydrates consist of 420-598 parts maltodextrin and 172-212 parts corn syrup solids.

2. The nutritional composition according to claim 1, characterized in that: The dietary fiber material is composed of 18-33 parts of galacto-oligosaccharide and 25-42 parts of fructo-oligosaccharide.

3. The nutritional composition according to claim 1, characterized in that: The composite trace minerals are composed of 0.03-0.04 parts of copper sulfate, 0.62-0.81 parts of ferric pyrophosphate, 0.07-0.08 parts of manganese sulfate, 0.0012-0.0023 parts of sodium selenite, 0.25-0.32 parts of zinc citrate, 0.0019-0.0028 parts of potassium iodide and 3-4 parts of maltodextrin.

4. The nutritional composition according to claim 1, characterized in that: The composite macro minerals are composed of 10.9-14.6 parts of tricalcium phosphate, 12.5-19.2 parts of calcium carbonate, 3.2-7.6 parts of magnesium carbonate, 15.1-17.6 parts of potassium chloride, 18.9-21.4 parts of potassium citrate, 32.1-32.6 parts of sodium citrate and 7-12 parts of maltodextrin.

5. The nutritional composition according to claim 1, characterized in that: The complex vitamin is composed of 2.68-3.00 parts of L-sodium ascorbate, 0.62-0.76 parts of vitamin E, 0.19-0.3 parts of nicotinamide, 0.1-0.2 parts of D-calcium pantothenate, 0.03-0.04 parts of pyridoxine hydrochloride, 0.04-0.06 parts of thiamine hydrochloride, 0.02-0.03 parts of vitamin A palmitate, 0.03-0.05 parts of riboflavin, 0.004-0.006 parts of folic acid, 0.001-0.003 parts of phytonadione, 0.0003-0.0004 parts of D-biotin, 0.0001-0.0003 parts of cholecalciferol, 0.00006-0.00007 parts of cyanocobalamin and 6-9 parts of maltodextrin.

6. The nutritional composition according to claim 1, characterized in that: It is prepared from the following raw materials in weight ratio: Protein 295 parts, fat 395 parts, carbohydrates 770 parts, dietary fiber Vitamins 58 parts, complex trace minerals 4.7 parts, complex macro minerals 119 parts, complex vitamins 10.7 parts, choline bitartrate 7.62 parts, L-carnitine 0.986 parts, taurine 0.762 parts; The protein material is composed of 37 parts of whey protein, 96 parts of soy protein and 162 parts of casein; The fat substance is a vegetable oil microcapsule powder made from 71 parts of medium-chain triglycerides, 62 parts of sunflower oil, 57 parts of soybean oil, 88 parts of low-erucic acid rapeseed oil and 117 parts of an edible carrier; the edible carrier is composed of 69.16 parts of oligomaltosaccharides, 32 parts of sodium caseinate, 4 parts of mono- and di-glycerol fatty acid esters, 0.3 parts of vitamin E, 8.3 parts of sodium tripolyphosphate, 0.04 parts of ascorbyl palmitate and 3.2 parts of sodium ascorbate; The carbohydrates consist of 598 parts maltodextrin and 172 parts corn syrup solids. The dietary fiber substance is composed of 33 parts of galacto-oligosaccharides and 25 parts of fructo-oligosaccharides; The composite trace minerals are composed of 0.04 parts of copper sulfate, 0.62 parts of ferric pyrophosphate, 0.08 parts of manganese sulfate, 0.0012 parts of sodium selenite, 0.32 parts of zinc citrate, 0.0028 parts of potassium iodide and 3.636 parts of maltodextrin; The complex macro minerals are composed of 14.6 parts of tricalcium phosphate, 19.2 parts of calcium carbonate, 7.6 parts of magnesium carbonate, 15.1 parts of potassium chloride, 18.9 parts of potassium citrate, 32.1 parts of sodium citrate and 11.5 parts of maltodextrin. The multivitamin consists of 2.68 parts of L-sodium ascorbate, 0.624 parts of vitamin E, 0.196 parts of nicotinamide, 0.12 parts of D-calcium pantothenate, 0.0336 parts of pyridoxine hydrochloride, 0.046 parts of thiamine hydrochloride, 0.02 parts of vitamin A palmitate, 0.035 parts of riboflavin, 0.0057 parts of folic acid, 0.0015 parts of phytonadione, 0.0003 parts of D-biotin, 0.0002 parts of cholecalciferol, 0.00007 parts of cyanocobalamin and 6.93763 parts of maltodextrin.

7. The nutritional composition according to claim 1, characterized in that: It is prepared from the following raw materials in weight ratio: 257 parts of protein substances, 383 parts of fat substances, 632 parts of carbohydrates, 60 parts of dietary fiber substances, 5.1 parts of complex trace minerals, 106 parts of complex macro minerals, 12.9 parts of complex vitamins, 6.21 parts of choline bitartrate, 1.1 parts of L-carnitine, and 0.42 parts of taurine; The protein substance is composed of 47 parts of whey protein, 112 parts of soy protein and 98 parts of casein; The fat substance is a vegetable oil microcapsule powder made from 66 parts of medium-chain triglycerides, 79 parts of sunflower oil, 51 parts of soybean oil, 72 parts of low-erucic acid rapeseed oil and 115 parts of an edible carrier; the edible carrier is composed of 68.66 parts of maltooligosaccharides, 31 parts of sodium caseinate, 4 parts of mono- and di-glycerol fatty acid esters, 0.3 parts of vitamin E, 8.3 parts of sodium tripolyphosphate, 0.04 parts of ascorbyl palmitate and 3 parts of sodium ascorbate; The carbohydrate is composed of 420 parts of maltodextrin and 212 parts of solid corn syrup; The dietary fiber substance is composed of 18 parts of galacto-oligosaccharides and 42 parts of fructo-oligosaccharides; The composite trace minerals are composed of 0.03 parts of copper sulfate, 0.81 parts of ferric pyrophosphate, 0.07 parts of manganese sulfate, 0.0023 parts of sodium selenite, 0.25 parts of zinc citrate, 0.0019 parts of potassium iodide and 3.636 parts of maltodextrin; The complex macro minerals are composed of 10.9 parts of tricalcium phosphate, 12.5 parts of calcium carbonate, 3.2 parts of magnesium carbonate, 17.6 parts of potassium chloride, 21.4 parts of potassium citrate, 32.6 parts of sodium citrate and 7.8 parts of maltodextrin. The multivitamin consists of 3 parts of L-sodium ascorbate, 0.76 parts of vitamin E, 0.28 parts of nicotinamide, 0.12 parts of D-calcium pantothenate, 0.03 parts of pyridoxine hydrochloride, 0.05 parts of thiamine hydrochloride, 0.03 parts of vitamin A palmitate, 0.04 parts of riboflavin, 0.0042 parts of folic acid, 0.002 parts of phytonadione, 0.0004 parts of D-biotin, 0.0001 parts of cholecalciferol, 0.00006 parts of cyanocobalamin and 8.58324 parts of maltodextrin.

8. A method for preparing the nutritional composition according to any one of claims 1 to 7, characterized in that: It includes the following steps: 1) Weigh the raw materials according to the ratio; 2) Mix choline bitartrate, L-carnitine, taurine, complex vitamins, and complex trace minerals, and stir at 20-30 rpm for 10-20 min to obtain premix 1; mix dietary fiber substances and whey protein, and stir at 20-30 rpm for 10-20 min to obtain premix 2; mix complex macro minerals and soy protein, and stir at 20-30 rpm for 10-20 min to obtain premix 3; 3) Premix 1, premix 2 and premix 3 obtained in step 2) are mixed, and stirred at 20-30 rpm for 20-30 min to obtain a total mixture 1; solid corn syrup and casein are mixed with the total mixture 1, and stirred at 20-30 rpm for 30-60 min to obtain a total mixture 2; fat substances, maltodextrin and the total mixture 2 are mixed, and stirred at 20-30 rpm for 40-60 min to obtain.

9. Use of the nutritional composition according to any one of claims 1 to 7 in the preparation of food or medicine for enhancing immunity, strengthening bones and / or improving constipation, characterized in that: The food or medicine has the effects of enhancing immunity, increasing bone density and / or facilitating bowel movements.

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