Desensitizing gel capable of inhibiting tooth demineralization and method for preparing same

Abstract

The present disclosure relates to the field of medical devices, and particularly, to a desensitizing gel capable of inhibiting tooth demineralization and a method for preparing same. The formula of the desensitizing gel disclosed herein comprises the following components in part by mass: 3-5 parts of a potassium salt, 5-15 parts of a carbomer, 5-8 parts of a fluoride, 0.5-1 part of glycyrrhizin, and 70-90 parts of purified water. According to the present disclosure, the coaction of the fluoride and the potassium salt on the tooth surface achieves the sealing of the dentinal tubules and the inhibition of tooth demineralization. By steps such as cross-linking and heating, the present disclosure makes the desensitizing gel system more stable in terms of the structure and more effective when acting on the teeth, thereby restoring gum health.

Description

Desensitizing gel capable of inhibiting tooth demineralization and preparation method thereof Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a desensitizing gel capable of inhibiting tooth demineralization and a preparation method thereof. Background Art

[0002] Tooth sensitivity is a common symptom of various dental diseases. Caries, wear, trauma, gum recession, exposed tooth neck, etc. may all cause tooth sensitivity. For these symptoms, the existing treatment methods can achieve certain effects, but there are still some shortcomings.

[0003] 1) Laser desensitization. Aim the probe of a medical laser transmitter at the allergic area at a distance of several millimeters. After one or two minutes of irradiation, desensitization is achieved. This method is fast-acting, has a high cure rate, lasts long, and is less likely to relapse, making it the preferred desensitization method. However, due to its high cost, it is not yet widely used in my country.

[0004] 2) Use dentin adhesives for desensitization. These materials were originally used to repair tooth defects. They were later found to be more effective for tooth desensitization and are less expensive than laser desensitization. However, they are less effective in preventing demineralization and are more prone to recurrence.

[0005] In view of this, we hope to develop a desensitizing gel that has good anti-demineralization effect, comprehensive effects and restores gum health faster to meet the needs of the majority of patients. Summary of the Invention

[0006] The purpose of the present invention is to address the deficiencies of the prior art and to provide a desensitizing gel that can inhibit tooth demineralization. The gel can effectively inhibit tooth demineralization and has a fast onset of action.

[0007] The technical solution for achieving the purpose of the present invention is:

[0008] A desensitizing gel capable of inhibiting tooth demineralization, comprising the following components in parts by mass:

[0009] 3-5 parts potassium salt, 5-15 parts carbomer, 5-8 parts fluoride, 0.5-1 part glycyrrhizin, 70-90 parts purified water.

[0010] Furthermore, the potassium salt is one or more of potassium nitrate, potassium chloride, potassium oxalate, and potassium citrate. The carbomer is carbomer 940.

[0011] Furthermore, the fluoride is one or more of sodium fluosilicate and sodium fluoride.

[0012] Furthermore, a method for preparing a desensitizing gel capable of inhibiting tooth demineralization comprises the following steps:

[0013] (1) Take 3-5 parts of potassium salt, 5-15 parts of carbomer, 5-8 parts of fluoride, 0.5-1 part of glycyrrhizin, and 70-90 parts of purified water by mass;

[0014] (2) Carbomer and potassium salt are mixed together in order according to the above-mentioned mass fractions to obtain mixture A;

[0015] (3) Dissolving mixture A in purified water, and then adding fluoride with stirring to obtain solution B;

[0016] (4) Add an appropriate amount of cross-linking agent to solution B and stir evenly to obtain mixture C;

[0017] (5) Heating the mixture C to an appropriate temperature and maintaining it for a certain period of time to allow the cross-linking reaction to occur;

[0018] (6) After the cross-linking reaction is completed, glycyrrhizin is added to the mixture and stirred evenly, and then cooled to room temperature to obtain a desensitizing gel. The glycyrrhizin added last can provide anti-inflammatory and anti-allergic effects, and dispersed in the desensitizing gel system can provide long-term protection against tooth demineralization and allergies.

[0019] Furthermore, the crosslinking agent in step (4) is alginate, glycerol, or a mixture of the two in any ratio, and the amount used is 0.1-0.3 wt%. The hydroxyl and carboxyl groups provided by the addition of the crosslinking agent can form ion exchange with potassium ions in the system, forming electrostatic attraction, which helps to disperse the main components fluoride and potassium salt. In addition, the crosslinking agent can form interchain crosslinking with other molecules through hydrogen bonds and covalent bonds to form a three-dimensional network structure, thereby enhancing the viscosity and strength of the desensitizing gel and facilitating its effect on teeth.

[0020] Furthermore, the temperature of the mixed cross-linking in step (5) is 30°C-45°C and maintained for 2-4 hours.

[0021] By adopting the above technical solution, the present invention has the following beneficial effects:

[0022] The present invention uses fluoride and potassium salt to act on the tooth surface together, sealing the dentinal tubules and inhibiting tooth demineralization. Previously, similar products only achieved certain effects by simply stirring and mixing the components, but the present invention uses key steps - cross-linking and heating to make the structure of the desensitizing gel system more stable and better act on the teeth. The desensitizing gel after thermal cross-linking has significant performance. When used, the desensitizing gel is dispersed on the tooth surface, which can prevent tooth decay, seal tooth pits and fissures, form a protective film, and provide long-lasting protection for the teeth, providing a stable and long-lasting anti-demineralization effect. It can also be used to eliminate allergic symptoms on exposed tooth necks and alleviate and prevent tooth allergy symptoms caused by dentin sensitivity. DETAILED DESCRIPTION

[0023] A desensitizing gel capable of inhibiting tooth demineralization, comprising the following components in parts by mass:

[0024] 3-5 parts potassium salt, 5-15 parts carbomer 940, 5-8 parts fluoride, 0.5-1 part glycyrrhizin, 70-90 parts purified water

[0025] Wherein, the potassium salt is one or more of potassium nitrate, potassium chloride, potassium oxalate and potassium citrate.

[0026] Wherein, the fluoride is one or more of sodium fluosilicate and sodium fluoride.

[0027] A method for preparing a desensitizing gel capable of inhibiting tooth demineralization comprises the following steps:

[0028] (1) Take 3-5 parts of potassium salt, 5-15 parts of carbomer 940, 5-8 parts of fluoride, 0.5-1 part of glycyrrhizin, and 70-90 parts of purified water by mass;

[0029] (2) Carbomer 940 and potassium salt are mixed together in order according to the above-mentioned mass fractions to obtain mixture A;

[0030] (3) Dissolving mixture A in purified water, and then adding fluoride with stirring to obtain solution B;

[0031] (4) Add an appropriate amount of cross-linking agent to solution B and stir evenly to obtain mixture C;

[0032] (5) Heating the mixture C to an appropriate temperature and maintaining it for a certain period of time to allow the cross-linking reaction to occur;

[0033] (6) After the cross-linking reaction is completed, glycyrrhizin is added to the mixture and stirred evenly, and then cooled to room temperature to obtain a desensitizing gel.

[0034] The cross-linking agent in step (4) is alginate, glycerol, or a mixture of the two in any ratio, and the amount used is 0.1-0.3 wt%.

[0035] Wherein, the temperature in step (5) is 30°C-45°C and maintained for 2-4 hours.

[0036] Example 1

[0037] A desensitizing gel capable of inhibiting tooth demineralization, comprising the following components in parts by mass:

[0038] 3 parts potassium salt, 5 parts carbomer 940, 5 parts fluoride, 0.5 parts glycyrrhizin, 70-90 parts purified water.

[0039] The potassium salt is potassium nitrate, and the fluoride is sodium fluorosilicate.

[0040] A method for preparing a desensitizing gel capable of inhibiting tooth demineralization comprises the following steps:

[0041] (1) Take 3 parts of potassium salt, 5 parts of carbomer 940, 5 parts of fluoride, 0.5 parts of glycyrrhizin, and 75 parts of purified water by mass;

[0042] (2) Carbomer 940 and potassium salt are mixed together in order according to the above-mentioned mass fractions to obtain mixture A;

[0043] (3) Dissolving mixture A in purified water, and then adding fluoride with stirring to obtain solution B;

[0044] (4) Add an appropriate amount of cross-linking agent to solution B and stir evenly to obtain mixture C;

[0045] (5) Heat the mixture C to 30°C and maintain for 2 h to allow the cross-linking reaction to occur;

[0046] (6) After the cross-linking reaction is completed, glycyrrhizin is added to the mixture and stirred evenly, and then cooled to room temperature to obtain a desensitizing gel.

[0047] Wherein, the cross-linking agent in step (4) is alginate, and the amount used is 0.1 wt%.

[0048] Example 2

[0049] A desensitizing gel capable of inhibiting tooth demineralization, comprising the following components in parts by mass:

[0050] 5 parts potassium salt, 15 parts carbomer 940, 8 parts fluoride, 1 part glycyrrhizin, 90 parts purified water.

[0051] The potassium salt is potassium nitrate and the fluoride is sodium fluoride.

[0052] A method for preparing a desensitizing gel capable of inhibiting tooth demineralization comprises the following steps:

[0053] (1) By mass: 5 parts potassium salt, 15 parts carbomer 940, 8 parts fluoride, 1 part glycyrrhizin, 90 parts purified water;

[0054] (2) Carbomer 940 and potassium salt are mixed together in order according to the above-mentioned mass fractions to obtain mixture A;

[0055] (3) Dissolving mixture A in purified water, and then adding fluoride with stirring to obtain solution B;

[0056] (4) Add an appropriate amount of cross-linking agent to solution B and stir evenly to obtain mixture C;

[0057] (5) Heat the mixture C to 45°C and maintain for 3 h to allow the cross-linking reaction to occur;

[0058] (6) After the cross-linking reaction is completed, glycyrrhizin is added to the mixture and stirred evenly, and then cooled to room temperature to obtain a desensitizing gel.

[0059] Wherein, the cross-linking agent in step (4) is alginate, and the amount used is 0.3 wt%.

[0060] Example 3

[0061] A desensitizing gel capable of inhibiting tooth demineralization, comprising the following components in parts by mass:

[0062] 4 parts potassium salt, 10 parts carbomer 940, 6 parts fluoride, 0.8 parts glycyrrhizin, 80 parts purified water.

[0063] The potassium salt is potassium chloride, and the fluoride is sodium fluorosilicate.

[0064] A method for preparing a desensitizing gel capable of inhibiting tooth demineralization comprises the following steps:

[0065] (1) By mass: 4 parts potassium salt, 10 parts carbomer 940, 6 parts fluoride, 0.8 parts glycyrrhizin, 80 parts purified water;

[0066] (2) Carbomer 940 and potassium salt are mixed together in order according to the above-mentioned mass fractions to obtain mixture A;

[0067] (3) Dissolving mixture A in purified water, and then adding fluoride with stirring to obtain solution B;

[0068] (4) Add an appropriate amount of cross-linking agent to solution B and stir evenly to obtain mixture C;

[0069] (5) Heat the mixture C to 35°C and maintain for 3 h to allow the cross-linking reaction to occur;

[0070] (6) After the cross-linking reaction is completed, glycyrrhizin is added to the mixture and stirred evenly, and then cooled to room temperature to obtain a desensitizing gel.

[0071] Wherein, the cross-linking agent in step (4) is alginate, and the amount used is 0.2 wt%.

[0072] Comparative Example 1: basically the same as Example 3, except that potassium salt is missing.

[0073] Comparative Example 2: basically the same as Example 3, the only difference being the lack of fluoride.

[0074] Comparative Example 3: basically the same as Example 3, except that no crosslinking agent was added and no crosslinking reaction was performed.

[0075] Comparative Example 4: Commercially available oral care gel (main ingredients: amino acid, fluoride).

[0076] The products prepared in Examples 1-3 of the present invention and the products obtained in Comparative Examples 1, 2, 3, and 4 were clinically tested on 140 middle-aged patients (aged 40-49) with dentin hypersensitivity (divided into seven groups of 20 patients each). The criteria were: ≥20 remaining teeth, all teeth were caries-free, and no prior dental therapy was performed. The affected teeth had similar levels of sensitivity, significant transient pain in response to temperature and sweet and sour stimuli, and significant pain in response to probe stimulation. Instructions for use: Apply the test gel to the tooth surfaces of each group of patients and leave it on for 20 minutes. The first follow-up visit was scheduled for 7 days, and the second follow-up visit was scheduled for 15 days.

[0077] 1) PI (Gingival Index) scoring criteria:

[0078] 0 = healthy gums;

[0079] 1 = Mild gingival inflammation: Slight change in gingival color and mild edema, no bleeding on probing;

[0080] 2 = Moderate gingival inflammation: gums are red, swollen and shiny, and bleed on probing;

[0081] 3 = Severe gingival inflammation: The gums are obviously red and swollen or have ulcers, and tend to bleed spontaneously.

[0082] 2) VAS evaluation criteria:

[0083] 0 = No pain

[0084] 1-3 = Mild pain

[0085] 4-6 = Moderate pain

[0086] 7-10 = Severe pain

[0087] 3) Demineralization inhibition effect score

[0088] (Measure the microhardness of the subjects' teeth surface, and then take the average value as the score, and reflect the effect through the microhardness of the teeth surface)

[0089]

[0090] According to the test, the therapeutic effect of Example 3 is the most significant, which significantly reduces the mean PI value of the patient, improves the gum health to a great extent in seven days, and the patient turns to mild pain. The improvement of the microhardness of the tooth surface is also obvious. The results obtained in Examples 1 and 2 are relatively close to those in Example 3. Within 14 days after treatment with the desensitizing gel disclosed in the present invention, the patient's physical and thermal stimulation symptoms completely disappeared, and they were all cured and had the effect of inhibiting tooth demineralization, with no adverse events. However, Comparative Examples 1 and 2 lack the main ingredients, and the resulting therapeutic effect is significantly reduced. Comparative Example 3 does not undergo a cross-linking reaction, and the effect is particularly reduced. The commercially available oral care subgingival gel tested in Comparative Example 4 has a weaker effect.

[0091] The specific embodiments described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above are only specific embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A desensitizing gel capable of inhibiting tooth demineralization, characterized in that: Its composition by mass parts includes the following: 3~5 parts potassium salt, 5~15 parts carbomer, 5~8 parts fluoride, 0.5~1 part glycyrrhizin, 70~90 parts purified water.

2. The desensitizing gel capable of inhibiting tooth demineralization according to claim 1, characterized in that: The potassium salt is one or more of potassium nitrate, potassium chloride, potassium oxalate and potassium citrate; the carbomer is carbomer 940.

3. The desensitizing gel capable of inhibiting tooth demineralization according to claim 2, characterized in that: The fluoride is one or more of sodium fluosilicate and sodium fluoride.

4. A method for preparing a desensitizing gel capable of inhibiting tooth demineralization as claimed in any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: (1) Take 3-5 parts of potassium salt, 5-15 parts of carbomer, 5-8 parts of fluoride, 0.5-1 part of glycyrrhizin, and 70-90 parts of purified water by mass; (2) mixing carbomer and potassium salt in order according to the above mass proportions to obtain a mixture A; (3) dissolving mixture A in purified water, and then adding fluoride with stirring to obtain solution B; (4) Add an appropriate amount of cross-linking agent to solution B and stir evenly to obtain a mixture C; (5) heating the mixture C to an appropriate temperature and maintaining it for a certain period of time to allow a cross-linking reaction to occur; (6) After the cross-linking reaction is completed, glycyrrhizin is added to the mixture and stirred evenly, and then cooled to room temperature to obtain a desensitizing gel.

5. The method for preparing the desensitizing gel capable of inhibiting tooth demineralization according to claim 4, characterized in that: The cross-linking agent in step (4) is alginate, glycerol or a mixture of the two in any ratio, and the amount used is 0.1-0.3 wt%.

6. The method for preparing the desensitizing gel capable of inhibiting tooth demineralization according to claim 4, characterized in that: The temperature of the mixed cross-linking in step (5) is 30°C-45°C and maintained for 2-4 hours.

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