Topical formulation for wound and burn treatments

Abstract

The invention relates to natural topical formulations comprising olive oil, beeswax, spruce tree resin, juniper tar soap, nutmeg, goat fat and paraffin, used in the treatment of wounds and burns.

Description

[0001] TOPICAL FORMULATION FOR WOUND AND BURN TREATMENTS

[0002] Technical Field

[0003] The invention relates to a topical formulation used in the treatment of wounds and burns, preferably in 1stand 2nddegree burns, as well as in the treatment of severe wounds that occur in bedridden patients after chemotherapy and plastic surgery operations.

[0004] In another aspect, the invention relates to a cream formulation that has all-natural ingredients and does not comprise any synthetic ingredients.

[0005] Prior Art

[0006] Burn and wound treatments are treatment methods applied in skin lesions that occur in all layers of the skin. While burns are damage caused by the effect of high heat or chemicals on the skin, wounds can be caused by cuts, scratches or various injuries on the skin.

[0007] Painkillers, antibiotics, skin tissue healing creams and preservatives in the form of wound dressings can be used in the treatment of burns and wounds. Painkillers are used to relieve pain in the damaged area. Antibiotics are used to reduce the risk of infection. Creams help speed up the healing process of the damaged area. Wound dressings keep the damaged area moist and reduce the risk of infection. In severe burns, skin grafts or other surgical interventions may be required. Treatment of wounds may also vary depending on the severity of the damage.

[0008] In the relevant technical field, it is generally possible to use creams, antibiotics or drugs providing more than one different function in order to restore the damaged areas in wound and burn treatments. As can be understood from here, there is no product that contains a single therapeutic composition or formulation. Drugs or formulations used to provide these functions comprise synthetic components. Products comprising synthetic components can cause skin irritations, chemical allergies, increased antibiotic resistance and hormone disorders in people. For this reason, studies are continuing rapidly to obtain a formulation that can be used in both wound and burn treatments in the relevant technical field and that can provide the functions of many different products together, and at the same time, to provide components in the formulation which do not comprise synthetic components. The use of natural ingredients in creams has become popular in recent years. The use of natural ingredients is preferred to reduce the negative effects of synthetic ingredients, provide healthier skin care and cause less harm to the environment. Vegetable oils, vitamins, plants such as aloe vera, honey and beeswax, and various oils can be used as natural ingredients.

[0009] In the application TR2012 / 14109 (i.Eren) , wound cream comprising resin, beeswax, olive oil and penicillin; in the application TR2022 / 019008 (Qukurova University), wound cream comprising olive oil, beeswax, pistachio tree resin and egg yolk; in the application TR2022 / 018350 (Grimax Bili§im), herbal cream formulation comprising olive oil, beeswax and vegetable oil selected from jasmine, lemon, lavender, rose oils; in the application TR2015 / 17718 (Mugla Sitki Kogman University), wound cream comprising centaury and sweetgum oil as well as beeswax and glycerin were explained.

[0010] As a result, there is a need for a formulation that comprises natural ingredients to remove the technical negativities caused by synthetic components, does not require the use of more than one product for wound and burn treatments, and has healing properties even in very severe cases.

[0011] Brief Description of the Invention

[0012] In the relevant technical field, wounds especially after chemotherapy, surgical operations and decubitus wounds in bedridden people are the most severe wounds, while the most severe cases in burns are 1stand 2nddegree burn cases. For the treatment of severe cases of wounds and burns, there is often the use of more than one therapeutic formulation, drug or composition that is used in different functions. While said formulations, drugs or compositions usually comprise synthetic ingredients, there are technical disadvantages where synthetic components can cause different symptoms in patients.

[0013] The main object of the invention is to obtain a formulation suitable for use even in the treatment of burns or wounds.

[0014] Another main object of the invention is to obtain a formulation that comprises natural ingredients and eliminates the symptoms that can occur in the use of synthetic ingredients. Another object of the invention is to obtain a formulation suitable for use to provide more than one function alone, even in burn and wound treatments.

[0015] Detailed Description of the Invention

[0016] In this detailed description, the subject of the invention is related to a topical formulation suitable for use in wound and burn treatments, and is explained only with examples that will not create any limiting effect for a better understanding of the subject.

[0017] The formulation of the present invention can generally be used in the treatment of burns and wounds. Specifically, it can be used in wounds which can be seen as severe cases after chemotherapy and surgical operations and wounds in bedridden people which can be the most severe wounds, while it can be used as a therapeutic for burns, even for 1stand 2nddegree burn cases.

[0018] Another innovative aspect of the invention is that it does not comprise synthetic ingredients as active ingredients. The formulation of the present invention comprises natural ingredients obtained naturally and these components do not cause any side effects in patients.

[0019] Another innovative aspect of the invention is that it eliminates the necessity of using different creams, ointments, drugs or formulations with many different functions to perform wound and burn treatments in the art, thanks to the components comprised in the formulation.

[0020] To provide all this, the present invention is a topical formulation for use in the treatment of wounds and burns, characterized in that the formulation comprises olive oil, beeswax, spruce tree resin, juniper tar soap, nutmeg, goat fat and paraffin.

[0021] The formulations of the present invention may preferably be in the form of creams, ointments, gels or similar topically applied forms. In the most preferred case, the formulation is in the form of a cream.

[0022] Olive oil is added to the formulation to soften the wound, relieve pain, fight infection and eliminate scars in burn and wound treatments. The chemical structure of olive oil comprises of saturated fatty acids (approximately 15% by weight), polyunsaturated fatty acids (approximately 15% by weight) and mainly monounsaturated fatty acids (approximately 70% by weight). The main feature of the fatty acid formulation of olive oil is the high level of monounsaturated acid. This ensures that it is a balanced component in accordance with the treatment principles and in terms of treatment.

[0023] Olive oil is preferably in the range of 50% to 75% by weight in the formulation. The reason why said olive oil is included in the cream in the mentioned weight ratios is that it provides a complete healing of the skin. In the most preferred case, the ratio of olive oil is 65% or 70% by weight.

[0024] Beeswax can help the skin absorb and retain moisture in burn and wound treatments, and is often used in skin care products and cosmetics. In this invention, beeswax is preferably contained in the formulation in the range of 5% to 15% by weight. The reason why said wax is included in the formulation in the mentioned weight ratios is to absorb moisture and prevent infection of the wound. In the most preferred case, the ratio of wax is 7% or 9% by weight.

[0025] The formulation of the present invention comprises resin obtained from spruce trees. The formulation comprises spruce tree resin to improve cracks and wear on the skin in burn and wound treatments. Spruce tree resin is widely used in the treatment of various diseases such as fungal infections such as ringworm, insect bites, burns, sunburn, birthmarks and colds. It contains hundreds of ingredients therein, including various antioxidants and flavonoids. The resin is a mixture of highly sensitive oils and natural resin acids. It also contains vitamins A, group B, C, E, D, K, PP and other vitamins. The resin contains rare trace elements: cobalt, barium, iodine, iron, zinc, chromium, copper. In this invention, spruce tree resin is preferably comprised in the formulation in the range of 1% to 10% by weight. At higher rates, there is a risk of allergic reactions. The reason why said spruce tree resin is included in the formulation in the mentioned weight ratios is that it restores the integrity of the skin. At the upper value of the specified weight ratios, spruce resin may have allergic side effects. In the most preferred case, the ratio of spruce tree resin is 5% or 7% by weight.

[0026] The formulation of the present invention comprises organic juniper tar soap. Juniper tar soap is also known as black soap. In this invention, juniper tar soap refers to a formulation obtained from a mixture of natural materials containing various oils, plant extracts and alkali. Thanks to the use of juniper tar soap in the formulation, it ensures that the skin is cleaned and the wound breathes in burn and wound treatments. Juniper tar soap has functions such as cleaning the skin, exhibiting antimicrobial properties against harmful microorganisms, and making the skin look bright. To provide these functions, the pH value of juniper tar soap is preferably between 8.5 and 9. In this invention, juniper tar soap can be comprised within the formulation with a pH of 8.5 to 9 at a value in the range of 1% to 5% by weight. In the most preferred case, the ratio of juniper tar soap is 2% or 3% by weight.

[0027] The formulation of the present invention comprises nutmeg. In this invention, nutmeg refers to a small seed that emerges as a result of removing the hard shell from the fruit of the nutmeg tree. Seeds are preferably ground. The formulation comprises nutmeg to provide antisepsis in burn and wound treatments and to prevent possible wound odors. In this invention, nutmeg is preferably comprised in the formulation in the range of 0.001% to 1.5% by weight, more specifically between 0.001% and 0.1% by weight. In the case where it is most preferred, it is 0.1%. If used at a value above the specified weight ratios, the nutmeg compound may cause side effects such as hallucinations, nausea, headache, vomiting and / or heart palpitations due to a substance called myristicin in its content.

[0028] The formulation of the present invention comprises goat fat, preferably goat visceral fat or goat butter. The weight ratio of goat fat in the formulation is preferably between 5% and 15%. In the most preferred case, the ratio of goat fat is about 11% or 14% by weight.

[0029] The formulation of the present invention comprises paraffin. Paraffin is a colorless, odorless type of candle. The weight ratio of paraffin in the formulation is preferably between 1% and 10%. In the most preferred case, the paraffin ratio is 2% or 3% by weight.

[0030] In a specific embodiment of the invention, the topical formulation comprises olive oil in the range of 50% to 75% by weight, beeswax between 5% and 15% by weight, spruce tree resin between 1% and 10% by weight, juniper tar soap between 1% and 5% by weight, nutmeg between 0.001% and 1.5% by weight, goat fat between 5% and 15% by weight, and paraffin between 1% and 10% by weight.

[0031] The topical formulation of the invention can be obtained by applying the process steps of the formulation method known in the art, which includes topical formulation production processes known in the art. For this reason, the formulation of the invention may comprise at least one excipient.

[0032] The formulation of the invention is preferably in the form of a cream. The formulation may also comprise preferably creaming excipients.

[0033] The formulation of the present invention comprise of natural ingredients and does not contain synthetic components that may cause any side effects for patients.

[0034] The formulation of the present invention may be suitable for use in the treatment of 1stand 2nddegree burns and severe wounds thanks to the components therein and weight ratio configurations. In addition, thanks to the ingredients comprised in the formulation, it eliminates the need to use more than one formulation, drug or composition for the treatment of these diseases.

[0035] The scope of protection of the invention is defined in the claims provided in the annex and is by no means limited to the examples described in this detailed description. It is clear that a person skilled in the art can put forward similar embodiments in the light of the above, without departing from the main theme of the invention.

[0036] Examples

[0037] Example 1. Cream formulation

[0038] The sample unit formula of the formulation in the cream formulation of the invention is below. Example 2. Cream formulation

[0039] The sample unit formula of the formulation in the cream formulation of the invention is below.

[0040] The above examples can be prepared according to the following method.

[0041] In order for the components not to stick to the bottom, it is necessary to pour preferably 150 grams of olive oil into the pan, and then add all the components in the specified ratios: Beeswax, Spruce tree resin, Juniper tar soap, Nutmeg, Goat fat, and Paraffin are added at the same time and boiled by heating.

[0042] From the moment boiling starts, it is boiled at high heat for 10 minutes and the foam and excess formed on top are removed. Then 5.350 liters (five liters of 350 milliliters) of olive oil is added and boiling is continued for 20 minutes.

[0043] Then the fire is turned off and it is left to cool. Before it cools completely, it is poured into pots and made ready for use.

[0044] Samples stored at room temperature for more than two years showed no deterioration in appearance or properties such as consistency, softness, and spreadability.

[0045] Example 3. Cream Formulation

[0046] The sample unit formula of the formulation in the cream formulation of the invention is below. Paraffin 200 grams

[0047] The method specified for Examples 1 and 2 can be also applied in Example 3.

[0048] Mode of administration

[0049] For burns on the skin, it is important to neutralize the heat, as the skin and subcutaneous tissues remain warm for the first 24 hours. For this, cream or ointment is applied directly to the surface of the burn, and this process helps to neutralize the heat during the burning phase. At the next stage, on the second or third day, it is applied thinly on a double layer of gauze and applied to the burned area in such a way that the damaged areas are completely covered. Then, the wound is loosely bandaged with a double layer of gauze so that the damaged tissue can breathe. The main object of the gauze is to attach the necrotic tissues formed on the wound and to clean the wound by sticking it to itself due to its structure. When the gauze is removed from the wound, it removes necrotic tissues, and there are no scars after healing.

[0050] Normally, scars remain after healing in burns. In standard medical practice, necrotic tissue is surgically removed from the wound, cut off, thus, naturally the patient suffers a lot of pain, bleeding occurs, and the general condition worsens. In addition, after healing, the tissue cannot regain its elasticity and its physical performance is limited and scars remain. The use of the above-mentioned method eliminates the need for surgical intervention, cleans necrotic tissues from the wound on time, does not cause any mechanical damage and does not leave scars, retaining skin elasticity after healing.

[0051] Patient studies related to the formulation of the invention are available, and the studies are currently ongoing. The technical effects related to the invention are being monitored through patient follow-up forms.

Claims

CLAIMS1. A topical composition for use in the treatment of wounds and burns, characterized in that the composition comprises olive oil, beeswax, spruce tree resin, juniper tar soap, nutmeg, goat fat and paraffin.

2. The topical composition according to claim 1 , characterized in that the amount of olive oil in the composition is between 50% and 75% by weight.

3. The topical composition according to one of the preceding claims, characterized in that the amount of beeswax in the composition is between 5% and 15% by weight.

4. The topical composition according to one of the preceding claims, characterized in that the amount of spruce tree resin in the composition is between 1% and 10% by weight.

5. The topical composition according to one of the preceding claims, characterized in that the amount of juniper tar soap in the composition is between 1 % and 5% by weight.

6. The topical composition according to one of the preceding claims, characterized in that the amount of nutmeg in the composition is between0.001 and 1.5% by weight.

7. The topical composition according to one of the preceding claims, characterized in that the amount of goat fat in the composition is between 5% and 15% by weight.

8. The topical composition according to one of the preceding claims, characterized in that the amount of paraffin in the composition is between 1% and 10% by weight.

9. The topical composition according to one of the preceding claims, characterized in that the wound treatment is the treatment of bedsores.

10. The topical composition according to any one of the claims 1-8, characterized in that the wound treatment is post-operative wound treatment, preferably plastic surgery post-operative wound treatment.

11. The topical composition according to any one of the claims 1-8, characterized in that the treatment of burns is the treatment of first and second degree burns.

12. The topical composition according to one of the preceding claims, characterized in that the composition is in the form of cream or ointment.

Images