Fungicidal combinations, mixtures and compositions and uses thereof

Abstract

The present invention provides fungicidal combination comprising: (i) flumetylsulforim, (ii) a DMI) fungicide, and (iii) a protectant fungicide.

Description

[0001] FUNGICIDAL COMBINATIONS, MIXTURES AND COMPOSITIONS AND USES THEREOF

[0002] Throughout this application various publications are referenced. The disclosures of 5 these documents in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains.

[0003] This application claims priority of U.S. Provisional Application No. 63 / 603,611, fded November 28, 2023, the contents of which are hereby incorporated by reference. 10

[0004] FIELD OF THE INVENTION

[0005] This disclosure concerns combinations comprising: (i) flumetylsulforim, (ii) DeMethylation Inhibitor (DMI) fungicide, and (iii) a protectant fungicide.

[0006] This disclosure also concerns compositions comprising the combinations described herein and methods of use of the combinations described herein. 15

[0007] BACKGROUND AND SUMMARY

[0008] Fungicides are compounds, of natural or synthetic origin, which act to protect plants against damage caused by fungi. Current methods of agriculture rely heavily on the use of fungicides. In fact, some crops cannot be grown usefully without the use of fungicides. Using fungicides allows a grower to increase the yield and the quality of 20 the crop, and consequently, increase the value of the crop. In most situations, the increase in value of the crop is worth at least three times the cost of the use of the fungicide.

[0009] Flumetylsulforim is a compound which provides control of a variety of pathogens affecting economically important crops including, but not limited to, the causal agent 25 of leaf blotch in wheat, Zymoseptoria tritici (SEPTTR) and fungi of the classes ascomycetes and basidiomycetes.

[0010] Flumetylsulforim has both preventive and curative effects. Uses of N3-substituted-Nl-sulfonyl-5-fluoropyrimidinone derivatives as fungicides were described in U.S. Patent No. 8,263,603, issued September 11, 2012, the content of which is incorporated herein by reference in its entirety. Methods of preparation of flumetylsulforim were described in U.S. Patent No. 9,850,215, issued December 26, 2017 and U.S. Patent No. 9,840,476, issued December 12, 2017, and PCT International 5 Application Publications Nos. WO 2021 / 059160 Al, published April 1, 2021 and WO 2021 / 181274, published September 16, 2021, the contents of each of which are incorporated herein by reference in their entirety.

[0011] PCT International Application Publication No. WO 2020 / 095181A1 also described fungicidal compositions for the control or prevention of fungal attack comprising 10 flumetylsulforim and a phytologically acceptable carrier material, and methods of use thereof.

[0012] Use of flumetylsulforim as seed treatment to prevent or control plant disease was described U.S. Patent Application Publication No. 2018 / 0000082, published on January 4, 2018. 15

[0013] Synergistic mixtures comprising flumetylsulforim and at least one fungicidal sterol biosynthesis inhibitor were described in U.S. Patent No. 9,526,245, issued December 27, 2016 and U.S. Patent No. 10,045,533, issued August 14, 2018.

[0014] Synergistic mixtures comprising flumetylsulforim and at least one succinate dehydrogenase inhibitor were described in U.S. Patent No. 9,532,570, issued January 20 3, 2017 and U.S. Patent No. 10,045,534, issued August 14, 2018.

[0015] Synergistic mixtures comprising flumetylsulforim and at least one multi-site inhibitor or strobilurin fungicide were described in U.S. Patent No. 9,538,753, issued January 10, 2017; U.S. Patent No. 10,051,862, issued August 21, 2018; and U.S. Patent No. 10,426,167, issued October 1, 2019. 25

[0016] Synergistic mixtures comprising flumetylsulforim and an amount of at least one fungicide selected from the group consisting of fluindapyr, pydiflumetofen, mefentrifluconazole, inpyrfluxam, isofetamid and Qi inhibitor were described in PCT International Application Publication No. WO 2021 / 014346 Al, published January 28, 2021. 30 Many fungicides are not useful in all situations and repeated usage of a single fungicide frequently leads to the development of resistance to the related fungicides. Consequently, research is being conducted to produce fungicides and combinations of fungicides that are safer, that have better performance, that are effective over long periods of time, that require lower dosages, that are easier to use, and that cost less. 5

[0017] It is an object of this disclosure to provide synergistic combinations, including mixtures, comprising flumetylsulforim, a DMI fungicide and a protectant fungicide. It is a further object of this disclosure to provide composition and uses of these synergistic combinations, including mixtures.

[0018] SUMMARY OF THE INVENTION

[0019] The present invention provides a fungicidal combination comprising:

[0020] (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide.

[0021] The present invention also provides a mixture comprising the combinations described herein. 5

[0022] The present invention also provides a composition comprising the combinations described herein.

[0023] The present invention also provides a method for treating a plant or locus against fungal infection comprising applying (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide. 10

[0024] The present invention also provides a method for treating a plant or a locus against fungal infection comprising applying an effective amount of any one of the combinations, mixtures, or compositions described herein to the plant or locus so as to thereby treat the plant or locus against fungal infection.

[0025] The present invention also provides a method for controlling a plant disease caused by phytopathologic fungi comprising contacting the plant or a locus of the plant with an effective amount of any one of the combinations, mixtures, or compositions described herein to thereby control the plant disease.

[0026] The present invention also provides a method for controlling fungal attack on a plant, 15 seed or seedling comprising applying any one of the combinations, mixtures, or compositions described herein to the plant, seed, seedling and / or a locus of the plant so as to thereby treat or prevent fungal attack on the plant, seed or seedling.

[0027] The present invention also provides a method for controlling fungal attack on a plant, seed or seedling comprising applying any one of the combinations, mixtures, or 20 compositions described herein to the plant, seed, seedling and / or locus of the plant so as to thereby control fungal attack on the plant, seed or seedling.

[0028] The present invention also provides a method of treating a plant, seed or seedling to produce a plant resistant to fungal attack, the method comprising applying any one of the combinations, mixtures, or compositions described herein to the plant, seed adapted to produce the plant, seeding adapted to produce the plant, or a locus of the plant so as to thereby produce a plant resistant to fungal attack.

[0029] The present invention also provides a method of protecting a plant from fungal attack, the method comprising applying any one of the combinations, mixtures, or 5 compositions described herein to the plant, a locus of the plant, or a seed or seedling adapted to produce the plant so as to thereby protect the plant from fungal attack.

[0030] The present invention also provides a plant resistant to fungal attack, wherein the seed adapted to produce the plant, the seedling adapted to produce the plant, or a locus of plant is treated with any one of the combinations, mixtures, or compositions described 10 herein.

[0031] The present invention also provides a plant seed or seedling adapted to produce a plant resistant to fungal attack, wherein the plant seed or seedling is treated with any one of the combinations, mixtures, or compositions described herein.

[0032] The present invention also provides a method for the controlling fungal attack on a plant 15 comprising applying any one of the combinations, mixtures, or compositions described herein to locus, plant, root, foliage, seed, locus of the fungus, and / or a locus in which the infestation is to be prevented so as to thereby control fungal attack on the plant.

[0033] The present invention also provides a method for the controlling plant and / or soil fungal diseases comprising applying any one of the combinations, mixtures, or compositions 20 described herein to soil, plant, root, foliage, seed, locus of the fungus, and / or a locus in which the infestation is to be prevented so as to thereby control plant and / or soil fungal diseases.

[0034] The present invention also provides a method for controlling plant disease caused by phytopathologic fungi comprising contacting the plant, propagation material of the 25 plant, or a locus of the plant with (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, to the plant or locus, so as to thereby control the plant disease.

[0035] The present invention also provides a method for controlling fungal attack on a plant, seed or seedling comprising applying to the plant, seed, seedling and / or a locus of the plant (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to thereby control fungal attack on the plant, seed or seedling.

[0036] The present invention also provides a method for protecting a plant, seed or seedling from fungal attack comprising applying to the plant, seed, seedling and / or locus of the plant (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to 5 thereby protect the plant, seed or seedling from fungal attack.

[0037] The present invention also provides use of any one of the combinations, mixtures, or compositions described herein for treating a plant or locus against fungal infection.

[0038] The present invention also provides any one of the combinations, mixtures, or compositions described herein for use to treat a plant or locus against fungal infection. 10

[0039] DETAILED DESCRIPTION

[0040] Definitions

[0041] Unless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by persons of ordinary skill in the art to which this subj ect matter belongs . 5

[0042] As used herein, the compound flumetylsulforim includes all solid forms thereof including, but not limited to, amorphous, crystalline, solvate or hydrate. Crystalline forms of flumetylsulforim are disclosed in PCT International Application Publication Nos. WO 2019 / 038583 Al, published February 28, 2019, and WO 2022 / 234487 published November 10, 2022, the entire content of which is hereby incorporated by 10 reference. The term “flumetylsulforim” also includes salts and optical isomers thereof.

[0043] As used herein, the term “combination” means an assemblage of agrochemicals for application either by simultaneous or contemporaneous application.

[0044] As used herein, the term “simultaneous” when used in connection with application of agrochemicals means that the agrochemicals are applied in an admixture, for example, a tank mix. For simultaneous application, the combination may be the admixture or separate containers each containing an agrochemical that are combined prior to application.

[0045] As used herein, the term “contemporaneous” when used in connection with application of agrochemicals means that an individual agrochemical is applied separately from another agrochemical or premixture at the same time or at times sufficiently close together that an activity that is additive or more than additive or synergistic relative to the activity of either agrochemical alone at the same dose is achieved.

[0046] As used herein, the term “mixture” refers to, but is not limited to, a combination in any physical form, e.g., blend, solution, suspension, dispersion, emulsion, alloy, or the like. 15

[0047] As used herein, the term “tank mix” means one or more of the components of the combination, mixture or composition of the present invention are mixed in a spray tank at the time of spray application or prior to spray application. As used herein, the term “composition” includes at least one of the combinations or mixtures of the present invention with agriculturally acceptable carrier.

[0048] As used herein, the term “effective” when used in connection with an amount of the active ingredient, combination, mixture or composition refers to an amount of the active ingredient, combination, mixture or composition that achieve a agriculturally beneficial level of control of the fungus, pathogen, and / or disease when applied to a plant, propagation material of the plant, soil or a locus.

[0049] As used herein, the term “fungicidally effective amount” refers to an amount of the active component that is commercially recommended for use to control fungi. The commercially recommended amount for each active component, often specified as application rates of the commercial formulation, may be found on the label accompanying the commercial formulation. The commercially recommended application rates of the commercial formulation may vary depending on factors such as the plant species and the fungus to be controlled.

[0050] As used herein, the term “effective” when used in connection with a method for treating a plant or locus against fungal infection means that the method provides an agriculturally beneficial level of treatment without significantly interfering with the 5 normal growth and development of the plant.

[0051] As used herein, the term “treating a plant or locus against fungal infection” includes, but is not limited to, protecting the plant or locus against fungal infection and / or controlling fungal infection of the plant or locus.

[0052] As used herein, the term “protecting the plant or locus against fungal infection” includes, but is not limited to, protecting the plant or locus against fungal attack, protecting the plant or locus from fungal disease, and / or preventing fungal infection of the plant or locus.

[0053] As used herein, the term “controlling fungal infection of the plant or locus” includes, but is not limited to, controlling fungal disease infecting the plant or locus, controlling a plant or soil disease caused by phytopathologic fungi, controlling fungal attack on the plant or locus, reducing fungal infection of the plant or locus, and / or curing plant or soil disease caused by phytopathologic fungi. As used herein, the term “more effective for protecting the plant or locus against fungal attack” includes, but is not limited to, prolonging the duration of protection against fungal attack after application and extending the protection period against fungal attack.

[0054] As used herein, the term “more effective for controlling fungal disease” includes, but is not limited to, increasing efficacy of fungal disease control and reducing the amount of time needed to achieve a given level of fungal control.

[0055] As used herein, the term “protectant application” means an application of one or more fungicide for preventing fungal infection of the plant or locus, wherein the fungicidal combination, mixture or composition is applied before infection occurs, before any disease symptoms are shown or when the disease pressure is low. Disease pressure may be assessed based on the conditions associated with disease development such as spore 5 concentration and certain environmental conditions.

[0056] As used herein the term “curative application” means an application of one or more fungicide for controlling fungal infection of the plant or locus, wherein the fungicidal combination, mixture or composition is applied after an infection or after disease symptoms are shown. 10

[0057] As used herein, the term "agriculturally acceptable carrier" means carriers which are known and accepted in the art for the formation of compositions for agricultural or horticultural use.

[0058] As used herein, the term “adjuvant” is broadly defined as any substance that itself is not an active ingredient, but which enhances or is intended to enhance the effectiveness 15 of the fungicide with which it is used. Adjuvants may be understood to include, spreading agents, penetrants, compatibility agents, and drift retardants.

[0059] As used herein, the term "agriculturally acceptable inert additives" is defined as any substance that itself is not an active ingredient but is added to the composition such as sticking agents, surfactants, synergists, buffers, acidifiers, anti-oxidation agent, 20 defoaming agents and thickeners. As used herein, the term "plant" includes reference to the whole plant, plant organ (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, and propagation material of the plant. As used herein the term "plant" includes reference to agricultural crops including field crops (soybean, maize, wheat, rice, etc.), vegetable crops (potatoes, cabbages, etc.) and fruits (peach, etc.).

[0060] As used herein the term "propagation material" is to be understood to denote all the generative parts of the plant such as seeds and spores, seedlings, and vegetative 5 structures such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons and buds.

[0061] As used herein, the term "locus" includes not only areas where fungal infection may already be shown, but also areas where fungal infection have yet to show, and also to areas under cultivation. Locus includes, but is not limited to, soil and other plant growth 10 medium.

[0062] As used herein the term “ha” refers to hectare.

[0063] As used herein, the term “excipient” refers to any chemical which has no significant pesticidal activity, such as surfactant(s), solvent(s), or adjuvant(s). One or more excipients can be added to any combination, mixture or composition disclosed herein. 15

[0064] As used herein, the term “stabilizing surfactant” is defined as any surfactant that increases the physical and / or chemical stability of the flumetylsulforim when added to a liquid combination, mixture or composition comprising the flumetylsulforim. In some embodiments, the stabilizing surfactant is effective for inhibiting crystal growth.

[0065] The term “a” or “an” as used herein includes the singular and the plural, unless 20 specifically stated otherwise. Therefore, the terms “a,” “an,” or “at least one” can be used interchangeably in this application.

[0066] Throughout the application, descriptions of various embodiments use the term “comprising”; however, it will be understood by one of skill in the art, that in some specific instances, an embodiment can be described using the language “consisting 25 essentially of’ or “consisting of.”

[0067] The term “about” herein specifically includes ±10% from the indicated values in the range. In addition, the endpoints of all ranges directed to the same component or property herein are inclusive of the endpoints, are independently combinable, and include all intermediate points and ranges.

[0068] It is understood that where a parameter range is provided, all integers within that range, and tenths thereof, are also provided by the invention as if the integers and tenths thereof are expressly described herein. For example, “5 g / ha to 120 g / ha” includes 5.0 g / ha, 5.1 5 g / ha, 5.2 g / ha, 5.3 g / ha, 5.4 g / ha, etc. up to 120 g / ha.

[0069] All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. 10

[0070] The following examples illustrate the practice of the present subject matter in some of its embodiments but should not be construed as limiting the scope of the present subject matter. Other embodiments apparent to persons of ordinary skill in the art from consideration of the specification and examples herein that fall within the spirit and scope of the appended claims are part of this invention. The specification, including the 15 examples, is intended to be exemplary only, without limiting the scope and spirit of the invention.

[0071] Aspects and embodiments of the present invention will now be described.

[0072] Fungicidal Combinations, Mixtures and Compositions

[0073] The present invention provides a fungicidal combination, comprising: (i) 20 flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide.

[0074] In some embodiments, the combination is synergistic.

[0075] In some embodiments, the amount of the flumetylsulforim, the DMI fungicide and the protectant fungicide are more effective for treating a plant or locus against fungal infection than when the amount of the flumetylsulforim, the DMI fungicide and the 25 protectant fungicide are applied alone.

[0076] In some embodiments, the amount of flumetylsulforim is more effective for treating a plant or locus against fungal infection when applied in combination with the amount of the DMI fungicide and the protectant fungicide, than when the same amount of the compound of flumetylsulforim is applied not in combination with the same amount of the DMI fungicide and the protectant fungicide.

[0077] In some embodiments, the amount of the DMI fungicide is more effective for treating a plant or locus against fungal infection when applied in combination with the amount 5 of the flumetylsulforim and protectant fungicide than when the same amount of the DMI fungicide is applied not in combination with the same amount of the flumetylsulforim and protectant fungicide.

[0078] In some embodiments, the amount of the flumetylsulforim improves the fungicidal efficacy of the amount of the DMI fungicide and the protectant fungicide compared to 10 when the same amount of DMI fungicide and the protectant fungicide are applied not in combination with the amount of the flumetylsulforim.

[0079] In some embodiments, fungicidal efficacy is increased by at least 10%, 20%, or 30%. In some embodiments, fungicidal efficacy is increased by at least 50%, 100%, 200% or 300%.

[0080] In some embodiments, fungicidal efficacy is measured in a treated area of the plant. In some embodiments, fungicidal efficacy is measured in an untreated area of the plant. In some embodiments, fungicidal efficacy is increased in a treated area of the plant. In some embodiments, fungicidal efficacy is increased in an untreated area of the plant.

[0081] In some embodiments, fungicidal efficacy is measure at least 7 days after treatment. In some embodiments, fungicidal efficacy is measure at least 14 days after treatment. In some embodiments, fungicidal efficacy is measure at least 21 days after treatment. In 15 some embodiments, fungicidal efficacy is measure at least 28 days after treatment.

[0082] In some embodiments, a substantially similar level of fungicidal efficacy is achieved by using a lesser amount of the flumetylsulforim and / or the DMI fungicide and / or the protectant fungicide.

[0083] In some embodiments, the amount of the flumetylsulforim in the combination is less 20 than the fungicidally effective amount of the flumetylsulforim when used alone. In some embodiments, the amount of the flumetylsulforim is less than its fungicidally effective amount. In some embodiments, the amount of the DMI fungicide in the combination is less than the fungicidally effective amount of the DMI fungicide when used alone. In some embodiments, the amount of the DMI is less than its fungicidally effective amount. In some embodiments, the amount of the protectant fungicide in the combination is less than the fungicidally effective amount of the protectant fungicide 5 when used alone. In some embodiments, the amount of the protectant fungicide is less than its fungicidally effective amount.

[0084] In some embodiments, the amount of the DMI fungicide, the amount of the protectant fungicide and the amount of the flumetylsulforim are more effective for treating a plant or locus against fungal infection than when the amount of the flumetylsulforim and the 10 amount of the DMI fungicide and the amount of the protectant fungicide are applied alone.

[0085] In some embodiments, treating a plant or locus against fungal infection comprises combating phytopathogenic diseases on the plant or locus.

[0086] In some embodiments, treating the plant or locus against fungal infection comprises protecting the plant or locus from fungal attack.

[0087] In some embodiments, treating the plant or locus against fungal infection comprises 15 preventing fungal infection of the plant or locus.

[0088] In some embodiments, treating the plant or locus against fungal infection comprises controlling fungal disease affecting the plant or locus.

[0089] In some embodiments, treating the plant or locus against fungal infection comprises controlling a fungal pathogen, a fungal pathogen group or a fungal pathogen class 20 affecting the plant or locus.

[0090] In some embodiments, treating the plant or locus against fungal infection comprises controlling a fungal disease caused by a fungal pathogen, a fungal pathogen group or a fungal pathogen class affecting the plant or locus.

[0091] In some embodiments, treating the plant or locus against fungal infection comprises reducing fungal infection of the plant or locus. In some embodiments, the combination reduces the amount of time needed to achieve a level of fungal control than when the amount of the flumetylsulforim and the amount of the DMI fungicide and the amount of the protectant fungicide are applied alone.

[0092] An example for reduction is, if each fungicide is applied alone achieves 50% control of fungal disease 7 days after application, the mixture or composition disclosed herein achieves 50% control of fungal diseases 2 days after application where each fungicide is applied at the amount.

[0093] In some embodiments, the amount of time needed to achieve a level of fungal control is reduced by at least 1 day, 2 days, 3 days, 4 day, 5 days, 7 days, 10 days, 14 days or 21 days, or 28 days.

[0094] In some embodiments, the combination improves plant development compared to the development of a plant affected by the same type and degree of fungal infection to which the combination is not applied. In some embodiments, the plant is a crop plant. In some embodiments, the DMI fungicide as part of the combination is more effective in improving plant development than when applied at the same amount alone. In some embodiments, the flumetylsulforim as part of the combination is more effective in improving plant development than when applied at the same amount alone. In some embodiments, the protectant fungicide as part of the combination is more effective in improving plant development than when applied at the same amount alone.

[0095] In some embodiments, the plant development is improved by treating the plant against fungal attack.

[0096] In some embodiments, improving plant development comprises enhancing crop plants. In some embodiment, improving plant development comprises improving plant quality.

[0097] Improving plant development includes, but is not limited to, enhancing the root 5 systems, enhancing shoot of the plant, enhancing plant vigor, enhancing greening effect on leaves and / or enhancing plant potential yield.

[0098] In some embodiments, improving plant development comprises enhancing the root system. In some embodiments, enhancement in root system is measured by root weight. In some embodiments, root weight is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.

[0099] In some embodiments, improving plant development comprises enhancing shoot of the plant. In some embodiments, enhancement in shoot is measured by shoot weight. In some embodiments, shoot weight is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 5

[0100] 50%, 60%, 70%, 80%, or 90%.

[0101] In some embodiments, improving plant development comprises enhancing plant vigor.

[0102] In some embodiments, plant vigor is assessed using the relative vigor index. In some embodiments, plant vigor is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%. 10

[0103] In some embodiments, improving plant development comprises enhancing greening effect on leaves. In some embodiments, greening effect on leaves is assessed using the relative vigor index. In some embodiments, greening effect on leaves is increased by at least 1%, 5%, or 10%.

[0104] In some embodiments, improving plant development comprises enhancing plant yield. 15 In some embodiments, plant yield is increased by at least 1%, 5%, 10, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.

[0105] In some embodiments, the amount of the flumetylsulforim in the combination is less than the fungicidally effective amount of the flumetylsulforim when the flumetylsulforim is applied not in combination with the DMI and protectant fungicides. 20

[0106] In some embodiments, the amount of the DMI fungicide in the combination is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is applied not in combination with the flumetylsulforim and protectant fungicide .

[0107] In some embodiments, the amount of the protectant fungicide in the combination is less than the fungicidally effective amount of the protectant fungicide when the protectant 25 fungicide is applied not in combination with the flumetylsulforim and DMI fungicide.

[0108] The present invention provides a synergistic fungicidal combination, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide. The present invention provides a fungicidal combination, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the combination is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone.

[0109] The present invention provides a fungicidal combination, comprising: (i) 5 flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the amount of the compound of flumetylsulforim, the DMI fungicide and the protectant fungicide when applied together is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone.

[0110] The present invention provides a fungicidal combination, comprising: (i) 10 flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the amount of the flumetylsulforim applied is less than the fungicidally effective amount of the flumetylsulforim when the flumetylsulforim is used alone, and / or wherein the amount of the DMI fungicide applied is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is used alone, and / or wherein the amount of the protectant fungicide applied is less than the fungicidally effective amount of the protectant fungicide when the protectant fungicide is used alone.

[0111] In some embodiments, the combination is synergistic.

[0112] In some embodiments, the combination is a mixture . In some embodiments, the mixture 15 is a tank mix.

[0113] In some embodiments, the tank mix is a mixture of (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein each of the (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide is in a different composition.

[0114] In some embodiments, the tank mix is a mixture of (i) flumetylsulforim, (ii) a DMI 20 fungicide and (iii) a protectant fungicide, wherein two of the (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide are formulated in a single composition that is tank mixed with the third component of the mixture. In some embodiments, the tank mix is a mixture of (i) a composition comprising flumetylsulforim and the DMI fungicide, and (ii) the protectant fungicide.

[0115] In some embodiments, a composition comprising (i) flumetylsulforim and (ii) a DMI fungicide is tank mixed with (iii) a protectant fungicide.

[0116] In some embodiments, a composition comprising (i) flumetylsulforim and (iii) a 5 protectant fungicide is tank mixed with (ii) a DMI fungicide.

[0117] In some embodiments, a composition comprising (ii) a DMI fungicide and (iii) a protectant fungicide is tank mixed with (i) flumetylsulforim.

[0118] In some embodiments, the tank mix comprises a mixture of (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, in a single composition. 10

[0119] In some embodiments, the mixture is synergistic.

[0120] The present invention provides a fungicidal mixture, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide.

[0121] The present invention provides a synergistic fungicidal mixture, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide. 15

[0122] The present invention provides a fungicidal mixture, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the mixture is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone.

[0123] The present invention provides a fungicidal mixture, comprising: (i) flumetylsulforim, 20 (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the amount of the flumetylsulforim, the DMI fungicide and the protectant fungicide when applied together is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone.

[0124] The present invention provides a fungicidal mixture, comprising: (i) flumetylsulforim, 25 (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the amount of the flumetylsulforim applied is less than the fungicidally effective amount of the flumetylsulforim when the flumetylsulforim is used alone, and / or wherein the amount of the DMI fungicide applied is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is used alone, and / or wherein the amount of the protectant fungicide applied is less than the fungicidally effective amount of the protectant fungicide when the protectant fungicide is used alone.

[0125] The present invention also provides a fungicidal composition comprising any one of the combinations or mixtures disclosed herein.

[0126] The present invention provides a fungicidal composition, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide.

[0127] The present invention provides a fungicidal composition, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the composition is more effective in treating a plant or locus against fungal infection than 5 when each fungicide at the same amount is applied alone.

[0128] The present invention provides a fungicidal composition, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the amount of the flumetylsulforim and the amount of the DMI fungicide and the amount of the protectant fungicide when applied together are more effective in treating a plant 10 or locus against fungal infection than when each fungicide at the same amount is applied alone.

[0129] The present invention provides a fungicidal composition, comprising: (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the amount of the flumetylsulforim applied is less than the fungicidally effective amount 15 of the flumetylsulforim when the flumetylsulforim is used alone, and / or wherein the amount of the DMI fungicide applied is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is used alone, and / or wherein the amount of the protectant fungicide applied is less than the fungicidally effective amount of the protectant fungicide when the protectant fungicide is used alone. In some embodiments, the composition comprises the flumetyl sulforim in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition, preferably from about 0. 1% to 20% by weight based on the total weight of the composition.

[0130] In some embodiments, the composition comprises DMI fungicide in an amount ranging 5 from about 0.1% to 90% by weight based on the total weight of the composition, preferably from about 0.1% to 20% by weight based on the total weight of the composition.

[0131] In some embodiments, the composition comprises protectant fungicide in an amount ranging from about 0.1% to 90% by weight based on the total weight of the 10 composition, preferably from about 0. 1% to 20% by weight based on the total weight of the composition.

[0132] In some embodiments, the amount of the flumetylsulforim in the composition is from about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5% to about 90%.

[0133] 93%, 95%, 98%, or 99% by weight based on the total weight of the composition. 15

[0134] In some embodiments, the amount of the DMI fungicide in the composition is from about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5% to about 90%.

[0135] 93%, 95%, 98%, or 99% by weight based on the total weight of the composition.

[0136] In some embodiments, the amount of the protectant fungicide in the composition is from about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5% to about 20

[0137] 90%, 93%, 95%, 98%, or 99% by weight based on the total weight of the composition.

[0138] In some embodiments, the amount of the flumetylsulforim in the composition is about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 10%, 15%, 20%, 25%,

[0139] 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95% by weight based on the total weight of the composition. 25

[0140] In some embodiments, the amount of the DMI fungicide in the composition is about

[0141] 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 10%, 15%, 20%, 25%.

[0142] 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95% by weight based on the total weight of the composition. In some embodiments, the amount of the protectant fungicide in the composition is about 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95% by weight based on the total weight of the composition.

[0143] In some embodiments, the composition further comprises a phytologically acceptable 5 carrier.

[0144] In some embodiments, the composition further comprises a stabilizing surfactant.

[0145] In some embodiments, the composition further comprises a phytologically acceptable adjuvant.

[0146] In some embodiments, the composition further comprising at least one pesticide. 10

[0147] In some embodiments, the composition is formulated for dilution in water before application.

[0148] In some embodiments, the composition is a concentrated formulation which can be dispersed in water, or another liquid, for application. In some embodiments, the composition is dust-like or granular, which can then be applied without further 15 treatment. The compositions disclosed herein can be prepared according to procedures which are conventional in the agricultural chemical art, but which are novel and important because of the synergistic effect they have.

[0149] The compositions that are applied most often are aqueous suspensions or emulsions.

[0150] Either such water-soluble, water-suspendable, or emulsifiable formulations are solids, 20 usually known as wettable powders, or liquids, usually known as emulsifiable concentrates, aqueous suspensions, or suspension concentrates. The present disclosure contemplates all vehicles by which the synergistic compositions can be formulated for delivery and used as fungicide.

[0151] Wettable powders, which may be compacted to form water-dispersible granules, 25 comprise an intimate mixture of the synergistic composition, a carrier and agriculturally acceptable surfactants. The concentration of the disclosed composition in the wettable powder is usually from about 10% to about 90% by weight, more preferably about 25% to about 75% by weight, based on the total weight of the formulation. The composition can be formulated, for example, as described in WO 2020 / 095181, the content of which is incorporated herein by reference in its entirety.

[0152] As used herein, flumetylsulforim is 5-fhioro-4-imino-3-methyl-l-tosyl-3,4- dihydropyri idin-2( l / / )-onc and possesses the structure:

[0153] Formula I

[0154] In some embodiments, the flumetylsulforim in the mixture, combination or composition described herein refers to any solid form including but not limited to amorphous, 5 crystalline, solvate or hydrate. Crystalline forms of the flumetylsulforim are described in PCT International Application Publication No. WO 2019 / 038583, published February 28, 2019, and WO 2022 / 234487, published November 10, 2022, the entire content of which is hereby incorporated by reference.

[0155] In some embodiments, the DMI fungicide in the mixture, combination or composition 10 described herein is selected from a group consisting of triazoles, triazolinthiones, imidazoles, pyrimidines, pyridines, and piperazines.

[0156] In some embodiments, the DMI is a triazole.

[0157] In some embodiments, the triazole is selected from a group consisting of cyproconazole, difenoconazole, epoxiconazole, hexaconazole, mefentrifluconazole, 15 metconazole, simeconazole, diniconazole, fenbuconazole, flusilazole, flutriafol, imibenconazole, myclobutanil, propiconazole, tebuconazole, tetraconazole, triadimefon, bitertanol, bromuconazole, fluquinconazole, ipconazole, penconazole, triadimenol, and triticonazole.

[0158] In some embodiments, the triazole is selected from a group consisting of 20 cyproconazole, difenoconazole, epoxiconazole, hexaconazole, mefentrifluconazole, metconazole, simeconazole, diniconazole, fenbuconazole, flusilazole, flutriafol, imibenconazole, myclobutanil, propiconazole, tebuconazole, tetraconazole, and triadimefon.

[0159] In some embodiments, the triazole is selected from a group consisting of cyproconazole, difenoconazole, epoxiconazole, hexaconazole, mefentrifluconazole, metconazole, simeconazole and tebuconazole. 5

[0160] In some embodiments, the triazole is tebuconazole.

[0161] In some embodiments, the DMI is a triazolinthione.

[0162] In some embodiments, the triazolinthione is prothioconazole.

[0163] In some embodiments, the DMI is an imidazole.

[0164] In some embodiments, the imidazole is selected from a group consisting of prochloraz, 10 imazalil, oxpoconazole, pefurazoate and triflumizole.

[0165] In some embodiments, the DMI is a pyrimidine.

[0166] In some embodiments, the pyrimidine is selected from a group consisting of fenarimol and nuarimol.

[0167] In some embodiments, the DMI is a pyridine. 15

[0168] In some embodiments, the pyridine is selected from a group consisting of pyrifenox and pyrisoxazole.

[0169] In some embodiments, the DMI is a piperazine.

[0170] In some embodiments, the piperazine is triforine.

[0171] In some embodiments, the protectant fungicide in the mixture, combination or 20 composition described herein is selected from a group consisting of mancozeb, chlorothalonil, copper hydroxide, copper oxichloride, copper penthaidrate, copper tribasic, fluazinam, sulphur, captan and folpet.

[0172] In some embodiments, the protectant fungicide is mancozeb.

[0173] In some embodiments, the protectant fungicide is chlorothalonil. 25 In some embodiments, the protectant fungicide is copper hydroxide.

[0174] In some embodiments, the protectant fungicide is copper oxychloride.

[0175] In some embodiments, the protectant fungicide is copper penthaidrate.

[0176] In some embodiments, the protectant fungicide is copper tribasic.

[0177] In some embodiments, the protectant fungicide is fluazinam. 5

[0178] In some embodiments, the protectant fungicide is sulphur.

[0179] In some embodiments, the protectant fungicide is captan.

[0180] In some embodiments, the protectant fungicide is folpet.

[0181] In some embodiments, the flumetylsulforim, the DMI fungicide and protectant fungicide in the combination, mixture or composition described herein are selected 10 from the list in Table 1 :

[0182] Table 1

[0183]

[0184] Each combination described in Table 1 represents a separate embodiment.

[0185] In some embodiments, the combination, mixture or composition described herein comprise the compounds flumetylsulforim, tebuconazole and mancozeb.

[0186] In some embodiments, the combination, mixture or composition described herein comprise the compounds flumetylsulforim, tebuconazole and chlorothalonil. 5 In some embodiments, the combination, mixture or composition described herein comprise the compounds flumetylsulforim, tebuconazole and fluazinam.

[0187] In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 5: 1 to 1:5. In some embodiments, the weight ratio of the flumetylsulforim to the DMI 5 fungicide of table 1, in the combination, mixture or composition lies within the range of about 4: 1 to 1:4. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 2: 1 to 1:5. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or 10 composition lies within the range of about 5: 1 to 1:3. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 2: 1 to 1 :2. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1.5: 1 to 1: 1.5. In 15 some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1.6:1 to 1: 1.6. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 2: 1 to 1 : 1. In some embodiments, the weight ratio of the flumetylsulforim to 20 the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:2. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1.25: 1 to 1:1. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1 , in the combination, 25 mixture or composition lies within the range of about 1.5: 1 to 1: 1. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1.7: 1 to 1:1.

[0188] In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1 , in the combination, mixture or composition lies within the range of about 1: 1 30 to 1: 1.3. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 1.4. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1: 1.5. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1: 1.6. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1 , in the combination, 5 mixture or composition lies within the range of about 1.7: 1 to 1: 1.6. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1. 7 : 1. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1.25: 1. In some embodiments, the weight ratio of the 10 flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1.04: 1. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1: 1. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1: 1.07. In some embodiments, 15 the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1: 1.2. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1: 1.33. In some embodiments, the weight ratio of the flumetylsulforim to the DMI fungicide of table 1, in the combination, mixture or composition is 1: 1.6. 20

[0189] The weight ratio may be any intermediate ratio or range selected from any of the above indicated ratios.

[0190] In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 5: 1 to 1:5. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in 25 the combination, mixture or composition lies within the range of about 4: 1 to 1:4. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 2: 1 to 1:5. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 5: 1 to 1:3. In 30 some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 2: 1 to 1:2. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1.5: 1 to 1: 1.5. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1.6: 1 to 1: 1.6. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 2: 1 to 1: 1. In 5 some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1: 1 to 1:2. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1.25 : 1 to 1 : 1. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in 10 the combination, mixture or composition lies within the range of about 1.5 : 1 to 1 : 1. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1.7: 1 to 1 : 1. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1: 1 to 1: 1.3. In 15 some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1: 1 to 1: 1.4. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1: 1 to 1: 1.5. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in 20 the combination, mixture or composition lies within the range of about 1: 1 to 1: 1.6. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition lies within the range of about 1.7: 1 to 1: 1.6. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1. 7 : 1. In some embodiments, the weight 25 ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1.25: 1. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1.04: 1. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1: 1. In some embodiments, the weight ratio of 30 the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1: 1.07. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1: 1.2. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1: 1.33. In some embodiments, the weight ratio of the flumetylsulforim to the Tebuconazole, in the combination, mixture or composition is 1: 1.6. The weight ratio may be any intermediate ratio or range selected from any of the above indicated ratios. 5

[0191] In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:30. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:27. In some embodiments, the weight ratio of the 10 flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:25. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :24. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of 15 table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1 : 22. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:20. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies 20 within the range of about 1: 1 to 1: 17. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1: 15. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 12. In some 25 embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1 : 10. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:9. In some embodiments, the weight ratio of the flumetylsulforim to 30 the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:8. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 7. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 5. In some embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition lies within the range of about 1: 1 to 1:2. In some 5 embodiments, the weight ratio of the flumetylsulforim to the protectant fungicide of table 1, in the combination, mixture or composition is 1 : 1. The weight ratio may be any intermediate ratio or range selected from any of the above indicated ratios.

[0192] In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1: 1 to 1:30. In some 10 embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1 :2 to 1:30. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :27. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the 15 combination, mixture or composition lies within the range of about 1 : 1 to 1 : 25. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :24. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :22. In some 20 embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :20. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 17. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the 25 combination, mixture or composition lies within the range of about 1 : 1 to 1 : 15. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 12. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1: 1 to 1: 10. In some 30 embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1: 1 to 1:9. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1: 1 to 1:8. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1: 1 to 1:7. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1: 1 to 1:5. In some 5 embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition lies within the range of about 1: 1 to 1:2. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1 : 1. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1:5. 10

[0193] In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1:7. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1:8. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1:9. In some embodiments, the weight ratio of 15 the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1: 10. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1 : 11. In some embodiments, the weight ratio of the flumetylsulforim to mancozeb, in the combination, mixture or composition is 1:12. The weight ratio may be any intermediate ratio or range selected from any of the 20 above indicated values.

[0194] In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1: 1 to 1:30. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 :2 to 1:30. In some 25 embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :27. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 25. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the 30 combination, mixture or composition lies within the range of about 1 : 1 to 1 :24. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :22. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :20. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 17. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the 5 combination, mixture or composition lies within the range of about 1 : 1 to 1 : 15. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 12. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 : 10. In some 10 embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1: 1 to 1:9. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1: 1 to 1:8. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the 15 combination, mixture or composition lies within the range of about 1: 1 to 1:7. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1: 1 to 1:5. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition lies within the range of about 1: 1 to 1:2. In some 20 embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1 : 1. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1:5. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1:7. In some embodiments, the weight 25 ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1:8. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1:9. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1: 10. In some embodiments, the weight ratio 30 of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1: 11. In some embodiments, the weight ratio of the flumetylsulforim to chlorothalonil, in the combination, mixture or composition is 1: 12. The weight ratio may be any intermediate ratio or range selected from any of the above indicated values. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1: 1 to 1:30. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:2 to 1:30. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, 5 mixture or composition lies within the range of about 1:1 to 1:27. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:1 to 1:25. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:1 to 1:24. In some 10 embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:1 to 1:22. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:1 to 1:20. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, 15 mixture or composition lies within the range of about 1:1 to 1: 17. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:1 to 1: 15. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:1 to 1: 12. In some 20 embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1:1 to 1: 10. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1 : 1 to 1 :9. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or 25 composition lies within the range of about 1 : 1 to 1 : 8. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1: 1 to 1:7. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1: 1 to 1:5. In some embodiments, the weight ratio of the 30 flumetylsulforim to fluazinam, in the combination, mixture or composition lies within the range of about 1: 1 to 1:2. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1:1. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1:5. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1:7. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1:8. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1:9. 5

[0195] In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1: 10. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1:11. In some embodiments, the weight ratio of the flumetylsulforim to fluazinam, in the combination, mixture or composition is 1:12. The weight ratio may be any 10 intermediate ratio or range selected from any of the above indicated values.

[0196] In some embodiments, the combination, mixture or composition is synergistic. In some embodiments, the combination, mixture or composition has synergistic effect in treating a plant or locus against fungal infection. In some embodiments, the combination, mixture or composition has synergistic curative effect. In some 15 embodiments, the combination, mixture or composition has synergistic protectant effect.

[0197] As will be readily appreciated, any material to which the disclosed compositions can be added may be used, provided they yield the desired utility without significant interference with the activity of these synergistic mixtures or compositions as 20 antifungal agents.

[0198] Methods of Use

[0199] The present invention provides a method for treating a plant or locus against fungal infection comprising applying (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide. 25

[0200] The present invention provides a method for treating a plant or locus against fungal infection comprising applying (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide to the plant or locus, so as to thereby treat the plant or locus against fungal infection, wherein the method is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone. 30 The present invention provides a method for treating a plant or locus against fungal infection comprising applying (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide to the plant or locus, so as to thereby treat the plant or locus against fungal infection, wherein the amount of the flumetylsulforim, the DMI fungicide and the protectant fungicide when applied together is more effective in treating a plant or 5 locus against fungal infection than when each fungicide at the same amount is applied alone.

[0201] The present invention provides a method for treating a plant or locus against fungal infection comprising applying (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, wherein the amount of the flumetylsulforim applied is less than 10 the fungicidally effective amount of the flumetylsulforim when the flumetylsulforim is used alone, and / or wherein the amount of the DMI fungicide applied is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is used alone, and / or wherein the amount of the protectant fungicide applied is less than the fungicidally effective amount of the protectant fungicide when the protectant fungicide is used alone.

[0202] The present invention also provides a method of treating a plant or locus against fungal infection comprising applying an effective amount of any one of the combinations, mixtures, or compositions disclosed herein to the plant or locus so as to thereby treat the plant or locus against fungal infection.

[0203] In some embodiments, the method is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone.

[0204] In some embodiments, the amount of the flumetylsulforim and the amount of the DMI fungicide and the amount of the protectant fungicide when applied together is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone.

[0205] In some embodiments, the amount of the flumetylsulforim applied is less than the fungicidally effective amount of the flumetylsulforim when the flumetylsulforim is used alone. In some embodiments, the amount of the DMI fungicide applied is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is used alone. In some embodiments, the amount of the protectant fungicide applied is less than the fungicidally effective amount of the protectant fungicide when the protectant fungicide is used alone.

[0206] In some embodiments, the method is effective for controlling fungal infection of the plant or locus.

[0207] In some embodiments, controlling fungal infection comprises controlling fungal disease infecting the plant or locus. In some embodiments, controlling fungal infection comprises controlling a plant or soil disease caused by phytopathologic fungi. In some embodiments, controlling fungal infection comprises controlling fungal attack on the plant or locus. In some embodiments, controlling fungal infection comprises reducing fungal infection of the plant or locus. In some embodiments, controlling fungal infection comprises curing a plant or soil disease caused by phytopathologic fungi.

[0208] In some embodiments, the method is effective for protecting the plant or locus against fungal infection.

[0209] In some embodiments, protecting the plant or locus against fungal infection comprises 5 protecting the plant or locus against fungal attack. In some embodiments, protecting the plant or locus against fungal infection comprises protecting the plant or locus from fungal disease. In some embodiments, protecting the plant or locus against fungal infection comprises preventing fungal infection of the plant or locus.

[0210] In some embodiments, the method comprises applying an effective amount of any one 10 of the combinations, mixtures, or compositions disclosed herein to propagation material of the plant. In some embodiment, the method comprises applying an effective amount of any one of the combinations, mixtures, or compositions disclosed herein to seed and / or seedling of the plant.

[0211] In some embodiments, the method comprises a protectant application of any one of the 15 combinations, mixtures or compositions disclosed herein. In some embodiments, the method comprises a curative application of any one of the combinations, mixtures or compositions disclosed herein. In some embodiments, the method comprises a protectant application of the flumetylsulforim and DMI fungicide and the protectant fungicide. In some embodiments, the method comprises a curative application of the flumetylsulforim and DMI fungicide and the protectant fungicide.

[0212] In some embodiments, the fungal attack is controlled by preventing fungal attack on 5 the plant, seed or seedling. In some embodiments, the fungal attack is controlled by treating the fungal attack on the plant, seed or seedling.

[0213] The present invention also provides a method for controlling a plant disease caused by phytopathologic fungi comprising contacting a plant, propagation material of the plant, or a locus of the plant with an effective amount of any one of the combinations disclosed 10 herein so as to thereby control the plant disease.

[0214] The present invention also provides a method for controlling fungal attack on a plant, seed or seedling comprising applying any one of the combinations disclosed herein to the plant, seed, seedling and / or a locus of the plant so as to thereby treat or prevent fungal attack on the plant, seed or seedling. 15

[0215] The present invention also provides a method for controlling fungal attack on a plant, seed or seedling comprising applying any one of the compositions or mixtures disclosed herein to the plant, seed, seedling and / or locus of the plant so as to thereby control fungal attack on the plant, seed or seedling.

[0216] The present invention also provides a method of treating a plant, seed or seedling to 20 produce a plant resistant to fungal attack, the method comprising applying any one of the compositions or mixtures disclosed herein to the plant, seed adapted to produce the plant, seeding adapted to produce the plant, or a locus of the plant so as to thereby produce a plant resistant to fungal attack.

[0217] The present invention also provides a method of protecting a plant from fungal attack, 25 the method comprising applying any one of the compositions or mixtures disclosed herein to the to the plant, a locus of the plant, or a seed or seedling adapted to produce the plant so as to thereby protect the plant from fungal attack.

[0218] The present invention also provides a plant resistant to fungal attack, wherein the seed adapted to produce the plant, the seedling adapted to produce the plant, or a locus of plant is treated with any one of the compositions or mixtures disclosed herein.

[0219] The present invention also provides a plant seed or seedling adapted to produce a plant resistant to fungal attack, wherein the plant seed or seedling is treated with any one of the compositions or mixtures disclosed herein. 5

[0220] The present invention also provides a method for the controlling fungal attack on a plant comprising applying any one of the compositions or mixtures described herein to soil, plant, root, foliage, seed, locus of the fungus, and / or a locus in which the infestation is to be prevented so as to thereby control fungal attack on the plant.

[0221] The present invention also provides a method for the controlling plant and / or soil fungal 10 diseases comprising applying any one of the compositions or mixtures described herein to soil, plant, root, foliage, seed, locus of the fungus, and / or a locus in which the infestation is to be prevented so as to thereby control plant and / or soil fungal diseases.

[0222] The present invention also provides a method for controlling plant disease caused by phytopathologic fungi comprising contacting the plant, propagation material of the 15 plant, or a locus of the plant with (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to thereby control the plant disease.

[0223] In some embodiments, the plant disease is controlled by protecting the plant from the plant disease. In some embodiments, the plant disease is controlled by curing the plant disease. 20

[0224] The present invention also provides a method for controlling fungal attack on a plant, seed or seedling comprising applying to the plant, seed, seedling and / or a locus of the plant (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to thereby control fungal attack on the plant, seed or seedling.

[0225] In some embodiments, the fungal attack is controlled by preventing fungal attack on 25 the plant, seed or seedling. In some embodiments, the fungal attack is controlled by treating the fungal attack on the plant, seed or seedling.

[0226] The present invention also provides a method for protecting a plant, seed or seedling from fungal attack comprising applying to the plant, seed, seedling and / or locus of the plant (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to thereby protect the plant, seed or seedling from fungal attack.

[0227] In some embodiments, the method comprises a protectant application of the flumetylsulforim and DMI fungicide and the protectant fungicide. In some embodiments, the method comprises a curative application of the flumetylsulforim and 5

[0228] DMI fungicide and the protectant fungicide.

[0229] In some embodiments, the method comprises applying the flumetylsulforim, DMI fungicide and the protectant fungicide before existence of a fungal pathogen infection. In some embodiments, the method comprises applying the flumetylsulforim, DMI fungicide and the protectant fungicide before fungal disease symptoms are shown. In 10 some embodiments, the method comprises applying the flumetylsulforim, DMI fungicide and the protectant fungicide when disease pressure is low.

[0230] In some embodiments, the method comprises applying the flumetylsulforim, DMI fungicide and the protectant fungicide after existence of a fungal pathogen infection. In some embodiments, the method comprises applying the flumetylsulforim, DMI 15 fungicide and the protectant fungicide after fungal disease symptoms are shown.

[0231] In some embodiments, the method is effective for reducing leaf necrosis. In some embodiments, leaf necrosis is reduced by at least 10%. In some embodiments, leaf necrosis is reduced by at least 25%. In some embodiments, leaf necrosis is reduced by at least 50%. In some embodiments, leaf necrosis is reduced by at least 75%. 20

[0232] In some embodiments, effectiveness of the method is evaluated at least one week after application of the flumetylsulforim and the DMI fungicide and the protectant fungicide. In some embodiments, effectiveness of the method is evaluated at least two weeks after application of the flumetylsulforim and the DMI fungicide and the protectant fungicide.

[0233] In some embodiments, effectiveness of the method is evaluated at least three weeks 25 after application of the flumetylsulforim and the DMI fungicide and the protectant fungicide. In some embodiments, effectiveness of the method is evaluated at least four weeks after application of the flumetylsulforim and the DMI fungicide and the protectant fungicide.

[0234] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant 30 fungicide are applied simultaneously.

[0235] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied contemporaneously.

[0236] In some embodiments, the flumetylsulforim and DMI fungicide and the protectant fungicide are applied sequentially. 5

[0237] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied separately.

[0238] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied together.

[0239] In some embodiments, the flumetylsulforim is applied separately from the DMI 10 fungicide and the protectant fungicide that are applied together.

[0240] In some embodiments, DMI fungicide is applied separately from the flumetylsulforim and protectant fungicide that are applied together.

[0241] In some embodiments, protectant fungicide is applied separately from the flumetylsulforim and DMI fungicide that are applied together. 15

[0242] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied together as a tank mix. In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are formulated as a single composition. In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are formulated as two separated compositions. 20 In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are formulated as three separated compositions.

[0243] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied in the form of any one of the combinations, mixtures or compositions disclosed herein. 25

[0244] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied to a portion of a plant, an area adjacent to a plant, soil in contact with a plant, soil adjacent to a plant, any surface adjacent to a plant, any surface in contact with a plant, a seed, and / or equipment used in agriculture. In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied to a locus of the plant, a locus in proximity to the plant, a locus of the fungi, or a locus in proximity to the fungi. In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied to soil in which the plant is 5 grown. In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied to soil in which the plant is to be grown.

[0245] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied at the time of planting.

[0246] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant 10 fungicide are applied 1 to 60 day(s) after planting.

[0247] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied 1 to 9 month(s) after planting.

[0248] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicides are applied once during a growth season. 15

[0249] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied at least one time during a growth season.

[0250] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied two or more times during a growth season.

[0251] In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant 20 fungicide are applied as a soil application. In some embodiments, the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied as a foliar application.

[0252] In some embodiments, the flumetylsulforim is applied at an amount from 25 g / ha to 150 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 60 g / ha to 150 g / ha. In some embodiments, the flumetylsulforim is applied at an amount 25 from 60 g / ha to 140 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 50 g / ha to 150 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 50 g / ha to 200 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 50 g / ha to 125 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 75 g / ha to 125 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 75 g / ha to 120 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 70 g / ha to 80 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 95 g / ha to 105 g / ha. In some embodiments, the flumetylsulforim is applied at an amount from 5 120 g / ha to 130 g / ha. In some embodiments, the flumetylsulforim is applied at an amount of 50 g / ha. In some embodiments, the flumetylsulforim is applied at an amount of 75 g / ha. In some embodiments, the flumetylsulforim is applied at an amount of 80 g / ha. In some embodiments, the flumetylsulforim is applied at an amount of 100 g / ha.

[0253] In some embodiments, the flumetylsulforim is applied at an amount of 120 g / ha. In 10 some embodiments, the flumetylsulforim is applied at an amount of 125 g / ha. In some embodiments, the flumetylsulforim is applied at an amount of 150 g / ha. In some embodiments, the flumetylsulforim is applied at an amount of 200 g / ha. All the possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed. 15

[0254] In some embodiments, the DMI is applied at an amount from 25 g / ha to 160 g / ha. In some embodiments, the DMI is applied at an amount from 25 g / ha to 150 g / ha. In some embodiments, the DMI is applied at an amount from 50 g / ha to 150 g / ha. In some embodiments, the DMI is applied at an amount from 50 g / ha to 200 g / ha. In some embodiments, the DMI is applied at an amount from 40 g / ha to 160 g / ha. In some 20 embodiments, the DMI is applied at an amount from 50 g / ha to 125 g / ha. In some embodiments, the DMI is applied at an amount from 60 g / ha to 125 g / ha. In some embodiments, the DMI is applied at an amount from 75 g / ha to 125 g / ha. In some embodiments, the DMI is applied at an amount from 80 g / ha to 120 g / ha. In some embodiments, the DMI is applied at an amount from 75 g / ha to 100 g / ha. In some 25 embodiments, the DMI is applied at an amount from 75 g / ha to 120 g / ha. In some embodiments, the DMI is applied at an amount from 70 g / ha to 80 g / ha. In some embodiments, the DMI is applied at an amount from 75 g / ha to 85 g / ha. In some embodiments, the DMI is applied at an amount from 95 g / ha to 105 g / ha. In some embodiments, the DMI is applied at an amount from 115 g / ha to 125 g / ha. In some 30 embodiments, the DMI is applied at an amount of 40 g / ha. In some embodiments, the DMI is applied at an amount of 50 g / ha. In some embodiments, the DMI is applied at an amount of 75 g / ha. In some embodiments, the DMI is applied at an amount of 80 g / ha. In some embodiments, the DMI is applied at an amount of 100 g / ha. In some embodiments, the DMI is applied at an amount of 120 g / ha. In some embodiments, the DMI is applied at an amount of 125 g / ha. In some embodiments, the DMI is applied at an amount of 150 g / ha. In some embodiments, the DMI is applied at an amount of 160 g / ha. In some embodiments, the DMI is applied at an amount of 200 g / ha. All the 5 possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed.

[0255] In some embodiments, the tebuconazole is applied at an amount from 25 g / ha to 160 g / ha. In some embodiments, the tebuconazole is applied at an amount from 25 g / ha to 150 g / ha. In some embodiments, the tebuconazole is applied at an amount from 50 g / ha 10 to 150 g / ha. In some embodiments, the tebuconazole is applied at an amount from 50 g / ha to 200 g / ha. In some embodiments, the tebuconazole is applied at an amount from 40 g / ha to 160 g / ha. In some embodiments, the tebuconazole is applied at an amount from 50 g / ha to 125 g / ha. In some embodiments, the tebuconazole is applied at an amount from 75 g / ha to 125 g / ha. In some embodiments, the tebuconazole is applied at 15 an amount from 80 g / ha to 120 g / ha. In some embodiments, the tebuconazole is applied at an amount from 75 g / ha to 100 g / ha. In some embodiments, the tebuconazole is applied at an amount from 75 g / ha to 120 g / ha. In some embodiments, the tebuconazole is applied at an amount from 60 g / ha to 125 g / ha. In some embodiments, the tebuconazole is applied at an amount from 70 g / ha to 80 g / ha. In some embodiments, 20 the tebuconazole is applied at an amount from 75 g / ha to 85 g / ha. In some embodiments, the tebuconazole is applied at an amount from 95 g / ha to 105 g / ha. In some embodiments, the tebuconazole is applied at an amount from 115 g / ha to 125 g / ha. In some embodiments, the tebuconazole is applied at an amount of 50 g / ha. In some embodiments, the tebuconazole is applied at an amount of 75 g / ha. In some 25 embodiments, the tebuconazole is applied at an amount of 80 g / ha. In some embodiments, the tebuconazole is applied at an amount of 100 g / ha. In some embodiments, the tebuconazole is applied at an amount of 120 g / ha. In some embodiments, the tebuconazole is applied at an amount of 125 g / ha. In some embodiments, the tebuconazole is applied at an amount of 150 g / ha. In some 30 embodiments, the tebuconazole is applied at an amount of 200 g / ha. All the possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed. In some embodiments, the protectant fungicide is applied at an amount from 200 g / ha to 1500 g / ha. In some embodiments, the protectant fungicide is applied at an amount from 400 g / ha to 1500 g / ha. In some embodiments, the protectant fungicide is applied at an amount from 500 g / ha to 1500 g / ha. In some embodiments, the protectant fungicide is applied at an amount from 400 g / ha to 1200 g / ha. In some embodiments, 5 the protectant fungicide is applied at an amount from 750 g / ha to 1500 g / ha. In some embodiments, the protectant fungicide is applied at an amount from 750 g / ha to 1000 g / ha. In some embodiments, the protectant fungicide is applied at an amount from 200 g / ha to 500 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 200 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 10 300 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 400 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 500 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 600 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 700 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 800 15 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 900 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 1000 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 1100 g / ha. In some embodiments, the protectant fungicide is applied at an amount of 1200 g / ha. All the possible sub-ranges as well as individual numerical values within that 20 range should be considered to have been specifically disclosed.

[0256] In some embodiments, the mancozeb is applied at an amount from 200 g / ha to 1500 g / ha. In some embodiments, the mancozeb is applied at an amount from 400 g / ha to 1500 g / ha. In some embodiments, the mancozeb is applied at an amount from 500 g / ha to 1500 g / ha. In some embodiments, the mancozeb is applied at an amount from 400 25 g / ha to 1200 g / ha. In some embodiments, the mancozeb is applied at an amount from 750 g / ha to 1500 g / ha. In some embodiments, the mancozeb is applied at an amount from 750 g / ha to 1000 g / ha. In some embodiments, the mancozeb is applied at an amount from 200 g / ha to 500 g / ha. In some embodiments, the mancozeb is applied at an amount of 200 g / ha. In some embodiments, the mancozeb is applied at an amount of 30 300 g / ha. In some embodiments, the mancozeb is applied at an amount of 400 g / ha. In some embodiments, the mancozeb is applied at an amount of 500 g / ha. In some embodiments, the mancozeb is applied at an amount of 600 g / ha. In some embodiments, the mancozeb is applied at an amount of 700 g / ha. In some embodiments, the mancozeb is applied at an amount of 800 g / ha. In some embodiments, the mancozeb is applied at an amount of 900 g / ha. In some embodiments, the mancozeb is applied at an amount of 1000 g / ha. In some embodiments, the mancozeb is applied at an amount of 1100 g / ha.

[0257] In some embodiments, the mancozeb is applied at an amount of 1200 g / ha. All the 5 possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed.

[0258] In some embodiments, the chlorothalonil is applied at an amount from 200 g / ha to 1500 g / ha. In some embodiments, the chlorothalonil is applied at an amount from 400 g / ha to 1500 g / ha. In some embodiments, the chlorothalonil is applied at an amount from 10

[0259] 500 g / ha to 1500 g / ha. In some embodiments, the chlorothalonil is applied at an amount from 400 g / ha to 1200 g / ha. In some embodiments, the chlorothalonil is applied at an amount from 750 g / ha to 1500 g / ha. In some embodiments, the chlorothalonil is applied at an amount from 750 g / ha to 1000 g / ha. In some embodiments, the chlorothalonil is applied at an amount from 200 g / ha to 500 g / ha. In some embodiments, the 15 chlorothalonil is applied at an amount of 200 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 300 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 400 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 500 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 600 g / ha. In some embodiments, the 20 chlorothalonil is applied at an amount of 700 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 800 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 900 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 1000 g / ha. In some embodiments, the chlorothalonil is applied at an amount of 1100 g / ha. In some embodiments, the 25 chlorothalonil is applied at an amount of 1200 g / ha. All the possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed.

[0260] In some embodiments, the fluazinam is applied at an amount from 200 g / ha to 1500 g / ha. In some embodiments, the fluazinam is applied at an amount from 400 g / ha to 30 1500 g / ha. In some embodiments, the fluazinam is applied at an amount from 500 g / ha to 1500 g / ha. In some embodiments, the fluazinam is applied at an amount from 400 g / ha to 1200 g / ha. In some embodiments, the fluazinam is applied at an amount from 750 g / ha to 1500 g / ha. In some embodiments, the fluazinam is applied at an amount from 750 g / ha to 1000 g / ha. In some embodiments, the fluazinam is applied at an amount from 200 g / ha to 500 g / ha. In some embodiments, the fluazinam is applied at an amount of 200 g / ha. In some embodiments, the fluazinam is applied at an amount of 5 300 g / ha. In some embodiments, the fluazinam is applied at an amount of 400 g / ha. In some embodiments, the fluazinam is applied at an amount of 500 g / ha. In some embodiments, the fluazinam is applied at an amount of 600 g / ha. In some embodiments, the fluazinam is applied at an amount of 700 g / ha. In some embodiments, the fluazinam is applied at an amount of 800 g / ha. In some embodiments, the fluazinam is applied at 10 an amount of 900 g / ha. In some embodiments, the fluazinam is applied at an amount of 1000 g / ha. In some embodiments, the fluazinam is applied at an amount of 1100 g / ha. In some embodiments, the fluazinam is applied at an amount of 1200 g / ha. All the possible sub-ranges as well as individual numerical values within that range should be considered to have been specifically disclosed. 15

[0261] When the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied in the form of the combinations, mixtures or compositions disclosed herein, the rate at which the combinations, mixture and / or composition is applied will depend upon the particular type of fungus to be controlled, the degree of control required and the timing and method of application. In general, the combinations, mixtures or 20 compositions described herein can be applied at an application rate of between about 250 gram per hectare (g / ha) and about 1900 g / ha.

[0262] The combinations, mixtures or compositions disclosed herein can be applied at an application rate of between about 250 g / ha and about 1900 g / ha based on the total amount of active ingredients. 25

[0263] The combinations, mixtures and compositions disclosed herein may be applied to control and / or prevent a variety of fungal pathogen and diseases associated therewith.

[0264] In some embodiments, the disease is but not limited to cercospora leaf spot (Cercospora beticola), leaf blight (Thanatephorus cucumeris), root rot (Thanatephorus cucumeris), and aphanomyces root rot (Aphanomyces cochlioides); powdery mildew (Erysiphe 30 graminis), fusarium Head blight (Fusarium graminearum, F. avenaceum, culmorum, Microdochium nivale), rust (for example, yellow rust (Puccinia striiformis), black rust (P. graminis), Brown rust (P. recondita), snow mold (Micrdochium nivale), typhula snow blight (Typhula sp.), loose smut (Ustilago tritici), stinking smut (Tilletia caries), eyespot (Pseudocercosporella herpotrichoides), Septoria leaf blotch (Mycosphaerella graminicola), glume blotch (Stagonospora nodorum), and tan spot (Pyrenophora tritici- 5 repentis); powdery mildew (Erysiphe graminis), loose smut (Fusarium graminearum, F. avenaceum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. hordei), loose smut (Ustilago nuda), scald (Rhynchosporium secalis), net blotch (Pyrenophora teres), spot blotch (Cochliobolus sativus), leaf stripe (Pyrenophora graminea), and damping-off caused by rhizoctonia fungus (Rhizoctonia solani); smut 10 (Ustilago maydis), southern leaf blight (Cochliobolus heterostrophus), zonate leaf spot (Gloeocercospora sorghi), southern rust (Puccinia polysora), gray leaf spot (Cercospora zeae-maydis), and damping-off caused by rhizoctonia fungus (Rhizoctonia solani); cotton damping-off caused by Rhizoctonia solani (Rhizoctonia solani); dollar spot (Sclerotinia homeocarpa), brown patch, and large patch (Rhizoctonia solani); melanose 15 (Diaporthe citri), scab (Elsinoe fawcetti), fruit rot (Penicillium digitatum, P. italicum), and Phytophthora disease (Phytophthora parasitica, Phytophthora citrophthora); blossom blight (Monilinia mali), canker (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), Altemaria leaf spot (Altemaria altemata apple pathotype), scab (Venturia inaequalis), bitter rot (Colletotrichum acutatum), and crown rot 20 (Phytophthora cactorum); scab (Venturia nashicola, V. pirina), black spot (Altemaria altemata Japanese pear pathotype), mst (Gymnosporangium haraeanum), phytophthora fmit rot, phytophthora crown and root rot (Phytophthora cactorum) and brown spot (Stemphilium Vesicarium); brown rot (Monilinia fmcticola), scab (Cladosporium carpophilum), and Phomopsis rot (Phomopsis sp.); anthracnose (Gloeosporium kaki), 25 and leaf spot (Cercospora kaki, Mycosphaerella nawae); powdery mildew (Sphaerotheca humuli), and anthracnose (Glomerella cingulata); Sigatoka disease (Mycosphaerella fijiensis, Mycosphaerella musicola); anthracnose (Elsinoe ampelina), ripe rot (Glomerella cingulata), powdery mildew (Uncinula necator), mst (Phakopsora ampelopsidis), black rot (Guignardia bidwellii), and downy mildew (Plasmopara 30 viticola); sclerotinia rot (Sclerotinia sclerotiomm), and rape seed damping-off caused by Rhizoctonia solani (Rhizoctonia solani); leaf spot (Cercospora personata), brown leaf spot (Cercospora arachidicola), and southern blight (Sclerotium rolfsii); caused by bacteria of Aspergillus spp., Penicillium spp., Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp., Rhizoctonia spp., Diplodia spp.; and Viral diseases of various plants mediated by Polymixa spp. or Olpidium spp; net blister blight (Exobasidium reticulatum), white scab (Elsinoe leucospila), gray blight (Pestalotiopsis sp.), and anthracnose (Colletotrichum theae-sinensis); brown spot (Altemaria longipes), 5 powdery mildew (Erysiphe cichoracearum), anthracnose (Colletotrichum tabacum), downy mildew (Peronospora tabacina), and black shank (Phytophthora nicotianae); early blight (Altemaria solani), late blight (Phytophthora infestans), pink rot (Phytophthora erythroseptica), and powdery scab (Spongospora subterranean f. sp. subterranea); blast (Magnaporthe grisea), brown spot (Cochliobolus miyabeanus), 10 sheath blight (Rhizoctonia solani), and bakanae disease (Gibberella fujikuroi); purple stain (Cercospora kikuchii), Sphaceloma scad (Elsinoe glycines), pod and stem blight (Diaporthe phaseolorum var. sojae), septoria brown spot (Septoria glycines), Cercospora leaf spot (Cercospora sojina), rust (Phakopsora pachyrhizi), phytophthora root and stem rot (Phytophthora sojae), damping-off caused by rhizoctonia fungus 15 (Rhizoctonia solani), target spot (Corynespora casiicola), and sclerotinia rot (Sclerotinia sclerotiorum); downy mildew (Plasmopara halstedii); anthracnose (Colletotrichum lagenarium), powdery mildew (Sphaerotheca fuliginea), gummy stem blight (Mycosphaerellamelonis), Fusarium wilt (Fusarium oxysporum), downy mildew (Pseudoperonospora cubensis), Phytophthora rot (Phytophthora sp.), and damping-off 20 (Pythium sp.); early blight (Altemaria solani), leaf mold (Cladosporium fulvum), and late blight (Phytophthora infestans); brown spot (Phomopsis vexans), and powdery mildew (Erysiphe cichoracearum); Altemaria leaf spot (Altemaria japonica), white spot (Cercosporella brassicae), clubroot (Plasmodiophora brassicae), and downy mildew (Peronospora parasitica); rust (Puccinia allii), and downy mildew (Peronospora 25 destmctor); anthracnose (Colletotrichum lindemthianum); powdery mildew (Erysiphe pisi); blackspot (Diplocarpon rosae), powdery mildew (Sphaerotheca pannosa), and downy mildew (Peronospora sparsa); downy mildew (Bremia lactucae), leaf blight (Septoria chrysanthemi-indici), and white mst (Puccinia horiana);

[0265] In some embodiments, the disease is selected from Phakopsora pachyrhizi, (Asian 30 Soybean Rust), Cercospora kikuchii (Cercospora leaf blight), Corynespora cassiicola (Soybean target spot). In some embodiments, the disease is Phakopsora pachyrhizi, (Asian Soybean Rust). In some embodiments, the disease is Cercospora kikuchii (Cercospora leaf blight). In some embodiments, the disease is Corynespora cassiicola (Soybean target spot).

[0266] In some embodiments, the plant is a crop plant. The methods of the present invention may be used on any crop plants, including but not limited to beet, cereals, com, cotton, environmental crops, fruits & nuts, grapes / vines, oilseed-rape / canola, plantation, 5 potatoes, rice, soybeans, vegetables & flowers and other crops. In some embodiment the crop is soybeans.

[0267] In some embodiments the methods of the present invention may be used on any crop plants, including but not limited to monocotyledons such as sugar cane, cereals, rice, maize (com), and / or; or dicotyledon crop such as beets (such as sugar beet or fodder 10 beet); fruits (such as pomes, stone fmits, or soft fruits, for example apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, or blackberries); leguminous plants (such as beans, lentils, peas, or soybeans); oil plants (such as rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, or groundnuts); cucumber plants (such as marrows, cucumbers or melons); fiber plants (such as cotton, 15 flax, hemp, or jute); citrus fmits (such as oranges, lemons, grapefruit, or mandarins); vegetables (such as spinach, lettuce, cabbages, carrots, tomatoes, potatoes, cucurbits, or paprika); lauraceae (such as avocados, cinnamon, or camphor); tobacco; nuts; coffee; tea; vines; hops; durian; bananas; natural mbber plants; and ornamentals (such as flowers, shmbs, broad-leaved trees, or evergreens, for example conifers). 20

[0268] In some embodiments, the plants are monocotyledonous plants, more preferably, cereals. In a specific embodiment, the cereal crop is wheat. In another specific embodiment, the cereal crop is triticale. In another specific embodiment, the cereal crop is rye. In another specific embodiment, the cereal crop is oat. In a further embodiment, the cereal crop is barley. In another embodiment, the crop plants are rice plants. In still 25 another embodiment, the crop plants are sugar cane plants. In yet another embodiment, the crop plants are com plants. In yet another embodiment, the crop plants are com soybeans.

[0269] In another embodiment, the crop plants are dicotyledonous plants.

[0270] The combination, mixture or composition disclosed herein may also be used as seed 30 treatment to prevent or control phytopathogenic fungi as described in U.S. Patent Application Publication No. 2018-0000082 (published January 4, 2018), the entire content of which is hereby incorporated by reference into this application.

[0271] In some embodiments, the combination, mixture or composition of the present invention further comprises at least one additional pesticide. In some embodiments, the pesticide is a fungicide, herbicide, insecticide, acaricides, or nematicide. 5

[0272] In some embodiments, the combination, mixture or composition further comprises a pesticide.

[0273] The present combination, mixture or composition can be applied to fungi or their locus. Application may be made by the use of conventional ground sprayers, granule applicators, and by other conventional means known to those skilled in the art. 10

[0274] Each embodiment disclosed herein is contemplated as being applicable to each of the other disclosed embodiments. Thus, all combinations of the various elements described herein are within the scope of the invention. In addition, the elements recited in the combination embodiments can be used in the mixture, composition, method and use embodiments described herein and vice versa.

[0275] While the present subject matter has been shown and described with reference to preferred embodiments thereof, it will be understood by those skilled in the art that many alternatives, modifications and variations may be made thereto without departing from the spirit and scope thereof. Accordingly, it is intended to embrace all such alternatives, modifications, and variations that fall within the spirit and broad scope of 15 the appended claims.

[0276] All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. 20

[0277] EXPERIMENTAL SECTION

[0278] Materials and Methods Flumetylsulforim can be prepared as described in international application publications W02015 / 103144, WO2015 / 103142, WO 2021 / 059160 and WO2021 / 181274.

[0279] Example

[0280] A series of experiments are conducted to evaluate the fungicidal control of Phakopsora pachyrhizi (Asian Soybean Rust), Cercospora kikuchii (Cercospora leaf blight), 5 Corynespora cassiicolci (Soybean target spot) in Soybean with flumetylsulforim, tebuconazole and a protectant fungicide. The experiment is conducted by applying flumetylsulforim and tebuconazole and a protectant fungicide selected from Chlorothalonil, Mancozeb and Fluazinam, alone or together. The compositions are diluted in water. 10

[0281] Treatment list

[0282] The Soybean plants are sprayed with each of the above treatments to test for fungicidal control of Phakopsorci pachyrhizi (Asian Soybean Rust), Cercospora kikuchii (Cercospora leaf blight), Corynespora cassiicola (Soybean target spot) in Soybean. Each of the above treatments is applied from 1 to 10 times according to the disease 5 development, applications occurring 7-14 days after the previous one. The treatments are composed of 4 replicates.

[0283] Evaluations are performed for the whole duration of the experiment.

[0284] Results show that the combination of flumetylsulforim, tebuconazole and chlorothalonil is more effective for treating soybean against Phakopsorci pachyrhizi 10 (Asian Soybean Rust) than each of flumetylsulforim, tebuconazole and chlorothalonil when applied alone at the same amount. Results show that the combination of flumetylsulforim, tebuconazole and chlorothalonil is more effective for treating soybean against Cercospora kikuchii (Cercospora leaf blight) than each of flumetylsulforim, tebuconazole and chlorothalonil when applied alone at the same 15 amount. Results show that the combination of flumetylsulforim, tebuconazole and chlorothalonil is more effective for treating soybean against Corynespora cassiicola (Soybean target spot) than each of flumetylsulforim, tebuconazole and chlorothalonil when applied alone at the same amount.

[0285] Results show that a lower application rate of flumetylsulforim, tebuconazole and / or 20 chlorothalonil is needed to achieve a similar level of control of Phakopsora pachyrhizi (Asian Soybean Rust) when flumetylsulforim, tebuconazole and chlorothalonil are applied in a combination. Results show that a lower application rate of flumetylsulforim, tebuconazole and / or chlorothalonil is needed to achieve a similar level of control of Cercospora kikuchii (Cercospora leaf blight) when flumetylsulforim, 25 tebuconazole and chlorothalonil are applied in a combination. Results show that a lower application rate of flumetylsulforim, tebuconazole and / or chlorothalonil is needed to achieve a similar level of control of Corynespora cassiicola (Soybean target spot) when flumetylsulforim, tebuconazole and chlorothalonil are applied in a combination.

[0286] Results show that the combination of flumetylsulforim, tebuconazole and mancozeb is more effective for treating soybean against Phakopsorci pachyrhizi (Asian Soybean Rust) than each of flumetylsulforim, tebuconazole and mancozeb when applied alone 5 at the same amount. Results show that the combination of flumetylsulforim, tebuconazole and mancozeb is more effective for treating soybean against Cercospora kikuchii (Cercospora leaf blight) than each of flumetylsulforim, tebuconazole and mancozeb when applied alone at the same amount. Results show that the combination of flumetylsulforim, tebuconazole and mancozeb is more effective for treating soybean 10 against Corynespora cassiicolci (Soybean target spot) than each of flumetylsulforim, tebuconazole and mancozeb when applied alone at the same amount.

[0287] Results show that a lower application rate of flumetylsulforim, tebuconazole and / or mancozeb is needed to achieve a similar level of control of Phakopsorci pachyrhizi (Asian Soybean Rust) when flumetylsulforim, tebuconazole and mancozeb are applied 15 in a combination. Results show that a lower application rate of flumetylsulforim, tebuconazole and / or mancozeb is needed to achieve a similar level of control of Cercospora kikuchii (Cercospora leaf blight) when flumetylsulforim, tebuconazole and mancozeb are applied in a combination. Results show that a lower application rate of flumetylsulforim, tebuconazole and / or mancozeb is needed to achieve a similar level of 20 control of Corynespora cassiicola (Soybean target spot) when flumetylsulforim, tebuconazole and mancozeb are applied in a combination.

[0288] Results show that the combination of flumetylsulforim, tebuconazole and fluazinam is more effective for treating soybean against Phakopsora pachyrhizi (Asian Soybean Rust) than each of flumetylsulforim, tebuconazole and fluazinam when applied alone 25 at the same amount. Results show that the combination of flumetylsulforim, tebuconazole and fluazinam is more effective for treating soybean against Cercospora kikuchii (Cercospora leaf blight) than each of flumetylsulforim, tebuconazole and fluazinam when applied alone at the same amount. Results show that the combination of flumetylsulforim, tebuconazole and fluazinam is more effective for treating soybean 30 against Corynespora cassiicola (Soybean target spot) than each of flumetylsulforim, tebuconazole and fluazinam when applied alone at the same amount. Results show that a lower application rate of flumetylsulforim, tebuconazole and / or fluazinam is needed to achieve a similar level of control of Phakopsorci pachyrhizi (Asian Soybean Rust) when flumetylsulforim, tebuconazole and fluazinam are applied in a combination. Results show that a lower application rate of flumetylsulforim, tebuconazole and / or fluazinam is needed to achieve a similar level of control of 5 Cercospora kikuchii (Cercospora leaf blight) when flumetylsulforim, tebuconazole and fluazinam are applied in a combination. Results show that a lower application rate of flumetylsulforim, tebuconazole and / or fluazinam is needed to achieve a similar level of control of Corynespora cassiicolci (Soybean target spot) when flumetylsulforim, tebuconazole and fluazinam are applied in a combination. 10

Claims

WHAT IS CLAIMED:

1. A fungicidal combination comprising:(i) flumetylsulforim, (ii) a DMI fungicide, and (iii) a protectant fungicide, wherein the ratio between the flumetylsulforim and the DMI fungicide is 4: 1 to 1:4.

2. The combination of claim 1, wherein: a) the combination is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone, b) the amount of the flumetylsulforim, the amount of DMI fungicide and the amount of the protectant fungicide when applied together is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone, and / or c) the amount of the flumetylsulforim applied is less than the fungicidally effective amount of the flumetylsulforim when the flumetylsulforim is used alone, and / or wherein the amount of the DMI fungicide applied is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is used alone, and / or wherein the amount of the protectant fungicide applied is less than the fungicidally effective amount of the protectant fungicide when the protectant fungicide is used alone.

3. The combination of claim 1 or 2, wherein the DMI fungicide is selected from a group consisting of triazoles, triazolinthiones, imidazoles, pyrimidines, pyridines, and piperazines.

4. The combination of claim 3, wherein the DMI fungicide is a triazole.

5. The combination of claim 4, wherein the triazole is selected from a group consisting of cyproconazole, difenoconazole, epoxiconazole, hexaconazole, mefentrifluconazole, metconazole, simeconazole, diniconazole, fenbuconazole, flusilazole, flutriafol, imibenconazole, myclobutanil, propiconazole,tebuconazole, tetraconazole, triadimefon, bitertanol, bromuconazole, fluquinconazole, ipconazole, penconazole, triadimenol, and triticonazole.

6. The combination of claim 3, wherein the DMI fungicide is a triazolinthione.

7. The combination of claim 6, wherein the triazolinthione is prothioconazole .

8. The combination of claim 3, wherein the DMI fungicide is an imidazole.

9. The combination of claim 8, wherein the imidazole is selected from a group consisting of prochloraz, imazalil, oxpoconazole, pefurazoate and triflumizole.

10. The combination of claim 3, wherein the DMI fungicide is a pyrimidine.

11. The combination of claim 10, wherein the pyrimidine is selected from a group consisting of fenarimol and nuarimol.

12. The combination of claim 3, wherein the DMI fungicide is a pyridine.

13. The combination of claim 12, wherein the pyridine is selected from a group consisting of pyrifenox and pyrisoxazole.

14. The combination of claim 3, wherein the DMI fungicide is a piperazine.

15. The combination of claim 14, wherein the piperazine is triforine.

16. The combination of claim 1 or 2, wherein the protectant fungicide is selected from a group consisting of mancozeb, chlorothalonil, copper hydroxide, copper oxichloride, copper penthaidrate, copper tribasic, fluazinam, sulphur, captan and folpet.

17. The combination of claim 1 or 2, wherein the DMI fungicide is tebuconazole and the protectant fungicide is mancozeb.

18. The combination of claim 1 or 2, wherein the DMI fungicide is tebuconazole and the protectant fungicide is chlorothalonil.

19. The combination of claim 1 or 2, wherein the DMI fungicide is tebuconazole and the protectant fungicide is fluazinam.

20. The combination of any one of claims 1-19, wherein weight ratio of the flumetylsulforim to the DMI fungicide is from about 2: 1 to 1:2.

21. The combination of any one of claims 1-20, wherein weight ratio of the flumetylsulforim to the protectant fungicide is from about 5: 1 to 1:5.

22. The combination of any one of claims 1-21, wherein the combination has synergistic effect in treating a plant or locus against fungal infection.

23. The combination of any one of claims 1-22 further comprising at least one stabilizing surfactant, and / or at least one phytologically acceptable adjuvant.

24. A mixture comprising the combination of any one of claims 1-23.

25. The mixture of claim 24, wherein the mixture is a tank mix.

26. A composition comprising the combination of any one of claims 1-23.

27. The composition of claim 26, wherein: a) the composition comprises the flumetylsulforim in an amount ranging from about 0. 1% to 90% by weight based on the total weight of the composition, and / or b) the composition comprises DMI fungicide in an amount ranging from about 0. 1 % to 90% by weight based on the total weight of the composition, and / or c) the composition comprises A protectant fungicide in an amount ranging from about 0.1% to 90% by weight based on the total weight of the composition.

28. The composition of claim 26 or 27, wherein the composition further comprises a phytologically acceptable carrier.

29. A method for treating a plant or locus against fungal infection comprising applying (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, to the plant or locus, so as to thereby treat the plant or locus against fungal infection,wherein: a) the flumetylsulforim is applied at an amount from 60 g / ha to 150 g / ha, and / or b) the DMI fungicide is applied at an amount from 60 g / ha to 125 g / ha.

30. A method for treating a plant or locus against fungal infection comprising applying an effective amount of the combination, mixture, or composition of any one of claims 1-28 to the plant or locus so as to thereby treat the plant or locus against fungal infection.

31. The method of claim 29 or 30, wherein: a) the method is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone, b) the amount of the flumetylsulforim and the amount of the DMI fungicide and the amount of the protectant fungicide when applied together is more effective in treating a plant or locus against fungal infection than when each fungicide at the same amount is applied alone, c) the amount of the flumetylsulforim applied is less than the fungicidally effective amount of the flumetylsulforim when the flumetylsulforim is used alone and / or the amount of the DMI fungicide applied is less than the fungicidally effective amount of the DMI fungicide when the DMI fungicide is used alone, and / or the amount of the protectant fungicide applied is less than the fungicidally effective amount of the protectant fungicide when the protectant fungicide is used alone, d) the method is effective for controlling fungal infection of the plant or locus, and / or e) the method is effective for protecting the plant or locus against fungal infection.

32. The method of claim 31, wherein:a) controlling fungal infection comprises controlling fungal disease infecting the plant or locus, controlling a plant or soil disease caused by phytopathologic fungi, controlling fungal attack on the plant or locus, reducing fungal infection of the plant or locus, and / or curing a plant or soil disease caused by phytopathologic fungi, and / or b) protecting the plant or locus against fungal infection comprises protecting the plant or locus against fungal attack, protecting the plant or locus from fungal disease, and / or preventing fungal infection of the plant or locus.

33. The method of any one of claims 29-32, wherein: a) the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied to propagation material of the plant, b) the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied to seed and / or seedling of the plant, c) the method comprises a protectant application of the flumetylsulforim and the DMI fungicide and the protectant fungicide, d) the method comprises a curative application of the flumetylsulforim and the DMI fungicide and the protectant fungicide, e) the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied simultaneously or contemporaneously, f) the flumetylsulforim and the DMI fungicide and the protectant fungicide are applied separately or together, and / or g) the method is effective for reducing leaf necrosis.

34. The method of any one of claims 29-33, wherein the protectant fungicide is applied at an amount from 200 g / ha to 1500 g / ha.

35. The method of any one of claims 29-34, wherein the fungal pathogen is Phakopsorci pachyrhizi (Asian Soybean Rust), Cercospora kikuchii (Cercospora leaf blight), or Corynespora cassiicola (Soybean target spot).

36. The method of any one of claims 29-35, wherein the fungal pathogen is Phakopsorci pachyrhizi (Asian Soybean Rust).

37. A method for controlling a plant disease caused by phytopathologic fungi comprising contacting the plant or a locus of the plant with an effective amount the combination, mixture or composition of any one of claims 1-28 so as to thereby control the plant disease.

38. A method for controlling fungal attack on a plant, seed or seedling comprising applying the combination, mixture or composition of any one of claims 1-28 to the plant, seed, seedling and / or a locus of the plant so as to thereby control fungal attack on the plant, seed or seedling.

39. A method for controlling fungal attack on a plant, seed or seedling comprising applying the combination, mixture or composition of any one of claims 1-28 to the plant, seed, seedling and / or locus of the plant so as to thereby control fungal attack on the plant, seed or seedling.

40. A method of treating a plant, seed or seedling to produce a plant resistant to fungal attack, the method comprising applying the combination, mixture or composition of any one of claims 1-28 to the plant, seed adapted to produce the plant, seeding adapted to produce the plant, or a locus of the plant so as to thereby produce a plant resistant to fungal attack.

41. A method of protecting a plant from fungal attack, the method comprising applying the combination, mixture or composition of any one of claims 1-28 to the to the plant, a locus of the plant, or a seed or seedling adapted to produce the plant so as to thereby protect the plant from fungal attack.

42. A plant resistant to fungal attack, wherein the seed adapted to produce the plant, the seedling adapted to produce the plant, or a locus of plant is treated with the combination, mixture or composition of any one of claims 1-28.

43. A plant seed or seedling adapted to produce a plant resistant to fungal attack, wherein the plant seed or seedling is treated with the combination, mixture orcomposition of any one of claims 1-28.

44. A method for the controlling fungal attack on a plant comprising applying the combination, mixture or composition of any one of claims 1-28 to soil, plant, root, foliage, seed, locus of the fungus, and / or a locus in which the infestation is to be prevented so as to thereby control fungal attack on the plant.

45. A method for the controlling plant and / or soil fungal diseases comprising applying the combination, mixture or composition of any one of claims 1-28 to soil, plant, root, foliage, seed, locus of the fungus, and / or a locus in which the infestation is to be prevented so as to thereby control plant and / or soil fungal diseases.

46. A method for controlling plant disease caused by phytopathologic fungi comprising contacting the plant, propagation material of the plant, or a locus of the plant with (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to thereby control the plant disease, wherein: a) the flumetylsulforim is applied at an amount from 60 g / ha to 150 g / ha, and / or b) the DMI fungicide is applied at an amount from 60 g / ha to 125 g / ha.

47. A method for controlling fungal attack on a plant, seed or seedling comprising applying to the plant, seed, seedling and / or a locus of the plant (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to thereby control fungal attack on the plant, seed or seedling, wherein: a) the flumetylsulforim is applied at an amount from 60 g / ha to 150 g / ha, and / or b) the DMI fungicide is applied at an amount from 60 g / ha to 125 g / ha.

48. A method for protecting a plant, seed or seedling from fungal attack comprising applying to the plant, seed, seedling and / or locus of the plant (i) flumetylsulforim, (ii) a DMI fungicide and (iii) a protectant fungicide, so as to thereby protect the plant, seed or seedling from fungal attack, wherein: a) the flumetylsulforim is applied at an amount from 60 g / ha to 150 g / ha, and / or b) the DMI fungicide is applied at an amount from 60 g / ha to 125 g / ha.

49. Use of the combination, mixture or composition of any one of claims 1-28 for treating a plant or locus against fungal infection.

50. The combination, mixture or composition of any one of claims 1-28 for use to treat a plant or locus against fungal infection.

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