Protease variants with improved bleach stability

Abstract

The invention relates to proteases which have proteolytic activity and comprise an amino acid sequence which is at least 70% and increasingly preferably at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5% and 98% identical to the amino acid sequence indicated in SEQ ID NO:1 over its entire length, wherein the protease, with respect to the numbering according to SEQ ID NO: 1, (i) has at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S at at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, and (ii) has at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L and Q256E at at least one of the positions corresponding to positions 29, 58, 89, 117 and 216. The invention also relates to a washing or cleaning agent, in particular bleach-containing washing or cleaning agent, preferably machine dishwashing agent, particularly preferably bleach-containing machine dishwashing agent, comprising a protease according to the invention.

Description

[0001] PROTEASE VARIANTS WITH IMPROVED BLEACH STABILITY

[0002] The invention lies in the field of enzyme technology. The invention relates to proteases whose amino acid sequence has been modified, particularly with regard to use in detergents and cleaning agents, in particular with regard to automatic dishwashing detergents, in order to improve their stability, in particular their stability in the presence of bleach, and to the nucleic acids encoding them and their preparation. The invention further relates to the uses of these proteases and methods in which they are used, as well as to detergents and cleaning agents containing them, in particular detergents and cleaning agents containing bleach, preferably automatic dishwashing detergents, particularly preferably automatic dishwashing detergents containing bleach.

[0003] Proteases are among the most technically important enzymes of all. They are the longest-established enzymes in detergents and cleaning agents and are contained in virtually all modern, high-performance detergents and cleaning agents. They degrade protein-containing soils on the items being cleaned. Among these, proteases of the subtilisin type (subtilases, subtilopeptidases, EC 3.4.21.62) are particularly important. These are serine proteases due to their catalytically active amino acids. They act as nonspecific endopeptidases and hydrolyze any acid amide bonds found within peptides or proteins. Their pH optimum is usually in the significantly alkaline range. An overview of this family is provided, for example, in the article "Subtilases: Subtilisin-like Proteases" by R. Siezen, pages 75-95 in "Subtilisin enzymes", edited by R. Bott and C. Betzel, New York, 1996. Subtilases are naturally produced by microorganisms.Among these, the subtilisins produced and secreted by Bacillus species are particularly worth mentioning as the most important group within the subtilases.

[0004] Examples of the subtilisin-type proteases preferably used in detergents and cleaning agents are the subtilisins BPN' and Carlsberg, the protease PB92, the subtilisins 147 and 309, the alkaline protease from Bacillus lentus, in particular from Bacillus lentus DSM 5483, subtilisin DY and the enzymes thermitase, proteinase K and the proteases TW3 and TW7, which can be classified as subtilases but no longer as subtilisins in the narrower sense, as well as variants of the aforementioned proteases which have an amino acid sequence altered compared to the parent protease. Proteases are modified in a targeted or random manner using methods known from the state of the art and thus optimized, for example, for use in detergents and cleaning agents. These include point, deletion or insertion mutagenesis or fusion with other proteins or protein fragments. For most of the proteases known from the state of the art, optimized variants are known. WO 2017 / 215925, for example, describesa protease from Bacillus gibsonii or variants thereof intended for washing and cleaning agents is disclosed.

[0005] In general, only selected proteases are suitable for use in surfactant- and / or bleach-containing preparations. Many proteases either do not exhibit sufficient catalytic performance in such preparations or are not sufficiently stable. Therefore, high catalytic activity and stability under conditions such as those encountered during a washing or cleaning process are particularly desirable for the use of proteases in detergents and cleaning agents. Consequently, prior art formulations containing proteases, surfactants, and / or bleach have the disadvantage that the proteases they contain do not exhibit satisfactory proteolytic activity and / or are not sufficiently stable under standard washing and / or cleaning conditions, and the formulations therefore do not demonstrate optimal cleaning performance on protease-sensitive soils.Protease-sensitive soils are preferably selected from the group consisting of blood, egg (yolk), milk and other protein-containing soils.

[0006] The most important criterion when cleaning textiles and / or hard surfaces is the cleaning performance on a wide variety of soils. Even though the cleaning performance of the detergents and cleaning agents used today is generally high, the problem arises, also due to the general trend towards the increased use of low-temperature programs, that many of the conventional detergents and cleaning agents have insufficient washing or cleaning performance on stubborn soils. Such inadequate washing or cleaning performance leads to consumer dissatisfaction and leads to such soils being pre-treated by the consumer, which in turn increases water and energy consumption. In addition, stubborn soils are usually addressed in common detergents and cleaning agents using other cleaning-active substances, such as phosphonates and / or phosphates.Due to sustainability efforts and concerns about the environmental impact of phosphates and phosphonates in detergents and cleaning agents, more and more detergents and cleaning agents are being developed that contain little or no phosphate and / or phosphonate-containing compounds.

[0007] Protein-containing soils, especially egg soils, and bleachable soils, especially tea soils, are stubborn stains that are often not satisfactorily removed. Such soils, especially bleachable soils, are typically addressed by adding bleaching agents to detergents and cleaning agents. However, enzymes are unstable in the presence of bleaching and / or oxidizing agents and lose their activity. This is especially true for liquid detergents and cleaning agents. Therefore, the washing and cleaning performance of conventional detergents and cleaning agents that combine enzymes and bleaching agents in one composition is significantly reduced.

[0008] There is therefore a need to improve the washing and cleaning performance of detergents and cleaning agents containing bleach and enzymes, in particular proteases, especially dishwasher detergents, particularly with regard to the cleaning performance on protease-sensitive soils. Particular attention is paid to improving the stability of detergents and cleaning agents containing enzymes and bleach, in particular the stability of enzymes in detergents and cleaning agents containing bleach, preferably the stability of proteases in detergents and cleaning agents containing bleach. The improvement in cleaning performance is preferably achieved in a temperature range from about 20°C to about 75°C, preferably from about 30°C to about 60°C, more preferably from about 40°C to about 55°C.

[0009] Surprisingly, it has now been found that a protease from Bacillus gibsonii or a sufficiently similar protease (based on sequence identity) which, based on the numbering according to SEQ ID NO:1, has (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution, which is selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, is improved in terms of its stability in the presence of bleaching agents, in particular oxidizing agents, compared to a reference protease (protease according to SEQ ID NO:1),and is therefore particularly suitable for use in bleach-containing washing or cleaning agents, in particular dishwasher detergents, preferably bleach-containing dishwasher detergents.

[0010] The invention therefore relates to a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.,

[0011] A preferred subject of the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.,

[0012] A further preferred subject of the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one, preferably two of the positions corresponding to positions 211 and 212, at least one, preferably two amino acid substitution(s) selected from the group consisting of M211 N, M211 L, P212D and P212H, preferably M211 L and / or P212D, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0013] The invention further relates to a process for producing a protease, comprising introducing (i) at least one amino acid substitution at at least one of the positions which, based on the numbering according to SEQ ID NO:1, correspond to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one amino acid substitution at at least one of the positions which, based on the numbering according to SEQ ID NO:1, correspond to positions 29, 58, 89, 117 and 216, selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, into a starting molecule having an amino acid sequence which is at least 70% and increasingly preferably at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%,92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5%, 99%, 99.5% or 100% sequence identity with the amino acid sequence given in SEQ ID NO:1 over its entire length.

[0014] A protease within the meaning of the present patent application therefore encompasses both the protease itself and a protease produced by a process according to the invention. All statements regarding the protease therefore refer both to the protease itself and to the proteases produced by corresponding processes, as well as to the corresponding processes, in particular to the production processes of the protease.

[0015] Further aspects of the invention relate to the nucleic acids encoding these proteases, proteases according to the invention or non-human host cells containing nucleic acids, and washing and cleaning agents comprising proteases according to the invention, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing agents, particularly preferably automatic dishwashing agents containing bleach, washing and cleaning processes, and uses of the proteases according to the invention in washing or cleaning agents, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing agents, particularly preferably automatic dishwashing agents containing bleach, for removing protease-sensitive soils.

[0016] These and other aspects, features, and advantages of the invention will become apparent to those skilled in the art from a study of the following detailed description and claims. Any feature of one aspect of the invention may be employed in any other aspect of the invention. Furthermore, it is to be understood that the examples contained herein are intended to describe and illustrate the invention, but not to limit it, and in particular, the invention is not limited to these examples.

[0017] Unless otherwise stated, all percentages are by weight (wt%).

[0018] Numerical ranges specified in the format "from x to y" include the specified values. If multiple preferred numerical ranges are specified in this format, it goes without saying that all ranges resulting from the combination of the different endpoints will also be included.

[0019] "At least one" as used herein means one or more, i.e. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or more.

[0020] The term "washing and cleaning agent" or "washing or cleaning agent" as used herein is synonymous with the term "agent" or "composition" or "washing and / or cleaning agent composition" and refers to a composition for cleaning textiles and / or hard surfaces, in particular dishes, as explained in the description.

[0021] "Approximately," "approximately," or "approximately," as used herein with reference to a numerical value, refers to the corresponding numerical value ±10%, preferably ±5%.

[0022] "Substantially free from" means that the composition or agent contains less than 2% by weight, preferably less than 1% by weight, more preferably less than 0.5% by weight and most preferably less than 0.1% by weight of the corresponding substance, based on the total weight of the composition / agent.

[0023] "Liquid," as used herein, includes liquids and gels, as well as pasty compositions. It is preferred that the liquid compositions be flowable and pourable at room temperature, but it is also possible that they have a yield point.

[0024] A substance, e.g. a composition or an agent, is solid according to the definition of the invention if it is in the solid state at 25°C and 1,013 mbar.

[0025] A substance, e.g., a composition or agent, is liquid according to the definition of the invention if it is in the liquid state at 25°C and 1,013 mbar. Liquid also includes gel. "Variant," as used herein, refers to natural or artificially produced variations of a native protease that have a modified amino acid sequence compared to the reference form.

[0026] The present invention is based on the surprising discovery of the inventors that amino acid substitutions at the positions described herein result in improved stability of this modified protease in detergents and cleaning agents, in particular bleach-containing detergents and cleaning agents, preferably automatic dishwashing detergents, particularly preferably bleach-containing automatic dishwashing detergents. The present invention is based in particular on the surprising discovery of the inventors that amino acid substitutions at the positions described herein result in improved stability of this modified protease in the presence of bleaching agents, in particular oxidizing agents.

[0027] In preferred embodiments, the changes according to the invention (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, to an improved stability of this modified protease in washing and cleaning agents, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing detergents, particularly preferably automatic dishwashing detergents containing bleach.

[0028] In preferred embodiments, the changes according to the invention (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, leads to improved stability of this modified protease in the presence of bleaching agents, in particular oxidizing agents.

[0029] This is particularly surprising insofar as no protease with such modifications has previously been described for use in detergents or cleaning agents, in particular bleach-containing detergents or cleaning agents, preferably automatic dishwashing detergents, particularly preferably bleach-containing automatic dishwashing detergents. In particular, such proteases modified according to the invention have not been described in connection with improved stability, in particular improved stability in the presence of bleaching agents, especially oxidizing agents.

[0030] In preferred embodiments, the protease according to the invention has (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the combination of the at least one amino acid substitution from group (i) and the at least one amino acid substitution from group (ii) leads to an improved stability of this modified protease in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents,particularly preferably bleach-containing dishwasher detergents.

[0031] In preferred embodiments, the protease according to the invention has (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the combination of the at least one amino acid substitution from group (i) and the at least one amino acid substitution from group (ii) leads to improved stability of this modified protease in the presence of bleaching agents, in particular oxidizing agents.

[0032] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.,

[0033] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least two of the positions corresponding to positions 29, 58, 89, 117 and 216,at least two amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0034] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least three of the positions corresponding to positions 29, 58, 89, 117 and 216,at least three amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0035] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least four of the positions corresponding to positions 29, 58, 89, 117 and 216,at least four amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0036] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at the positions corresponding to positions 29, 58, 89, 117 and 216,five amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0037] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.,

[0038] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least two of the positions corresponding to positions 29, 58, 89, 117 and 216,at least two amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0039] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least three of the positions corresponding to positions 29, 58, 89, 117 and 216,at least three amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0040] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least four of the positions corresponding to positions 29, 58, 89, 117 and 216,at least four amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0041] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at the positions corresponding to positions 29, 58, 89, 117 and 216,five amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0042] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 211 and 212, at least one amino acid substitution selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F,M1171, M117L, M117V, M216A, M216F and M216L.,

[0043] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 211 and 212, at least one amino acid substitution selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least two of the positions corresponding to positions 29, 58, 89, 117 and 216, at least two amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F,M1171, M117L, M117V, M216A, M216F and M216L.

[0044] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 211 and 212, at least one amino acid substitution selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least three of the positions corresponding to positions 29, 58, 89, 117 and 216, at least three amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F,M1171, M117L, M117V, M216A, M216F and M216L.

[0045] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 211 and 212, at least one amino acid substitution selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least four of the positions corresponding to positions 29, 58, 89, 117 and 216, at least four amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F,M1171, M117L, M117V, M216A, M216F and M216L.

[0046] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 211 and 212, at least one amino acid substitution selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at the positions corresponding to positions 29, 89, 117 and 216, five amino acid substitutions selected from the group consisting of A29G, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L existing group selected.,

[0047] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, two amino acid substitutions selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L consisting of a group.,

[0048] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, two amino acid substitutions selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least two of the positions corresponding to positions 29, 58, 89, 117 and 216, at least two amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L existing group selected.,

[0049] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, two amino acid substitutions selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least three of the positions corresponding to positions 29, 58, 89, 117 and 216, at least three amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L existing group selected.,

[0050] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, two amino acid substitutions selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least four of the positions corresponding to positions 29, 58, 89, 117 and 216, at least four amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L existing group selected.,

[0051] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, two amino acid substitutions selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at the positions corresponding to positions 29, 58, 89, 117 and 216, five amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L existing group selected.,

[0052] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, the amino acid substitutions M211L and P212D, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0053] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, the amino acid substitutions M211L and P212D, and (ii) at least two of the positions corresponding to positions 29, 58, 89, 117 and 216, at least two amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0054] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, the amino acid substitutions M211L and P212D, and (ii) at least three of the positions corresponding to positions 29, 58, 89, 117 and 216, at least three amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0055] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, has (i) at the positions corresponding to positions 211 and 212, the amino acid substitutions M211L and P212D, and (ii) at least four of the positions corresponding to positions 29, 58, 89, 117 and 216, at least four amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0056] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease has, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, the amino acid substitutions M211L and P212D, and (ii) at the positions corresponding to positions 29, 58, 89, 117 and 216, five amino acid substitutions selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

[0057] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, (i) an amino acid substitution or amino acid substitution combination selected from the group consisting of I43V, M122L-N154S-T156A, M211 N-P212D, M211 L-P212D, G160S, D127P-M211 L-P212D, P212H and Q12L-M122L-A222S, and (ii) an amino acid substitution or amino acid substitution combination selected from the group consisting of A29G, A29G-D58P, A29G-Y89A, A29G-M117A, A29G-M117F, A29G-M1171, A29G- M117L, A29G-M117V,<h2 style=";text-align:left;direction:ltr">A29G-M216A, A29G-M216F, A29G-M216L, A29G-D58P-Y89A, A29G-D58P- M117A, A29G-D58P-M117F, A29G-D58P-M1171, A29G-D58P-M117L, A29G-D58P-M117V, A29G- D58P-M216A, A29G-D58P-M216F, A29G-D58P-M216L, A29G-Y89A-M117A, A29G-Y89A-M117F, A29G-Y89A-M1171, A29G-Y89A-M117L, A29G-Y89A-M117V, A29G-Y89A-M216A, A29G-Y89A-M216F, A29G-Y89A-M216L, A29G-M117A-M216A, A29G-M117A-M216F, A29G-M117A-M216L, A29G-D58P-Y89A-M117A, A29G-D58P-Y89A-M117F, A29G-D58P-Y89A-M1171, A29G-D58P-Y89A-M117L, A29G-D58P-Y89A-M117V, A29G-D58P-Y89A-M216A, A29G-D58P-Y89A-M216F, A29G- D58P-Y89A-M216L, A29G-Y89A-M117A-M216A, A29G-Y89A-M117A-M216F, A29G-Y89A-M117A-M216L, A29G-Y89A-M117F-M216A, A29G-Y89A-M117F-M216F, A29G-Y89A-M117F-M216L, A29G-Y89A-M117I-M216A, A29G-Y89A-M117I-M216F, A29G-Y89A-M117I-M216L, A29G-Y89A-M117L- M216A, A29G-Y89A-M117L-M216F, A29G-Y89A-M117L-M216L, A29G-Y89A-M117V-M216A, A29G-Y89A-M117V-M216F, A29G-Y89A-M117V-M216L, D58P, D58P-Y89A, D58P-M117A, D58P-M117F, D58P-M1171, D58P-M117L, D58P-M117V, D58P-M216A,D58P-M216F, D58P-M216L, D58P-Y89A- M117A, D58P-Y89A-M117F, D58P-Y89A-M1171, D58P-Y89A-M117L, D58P-Y89A-M117V, D58P- Y89A-M216A, D58P-Y89A-M216F, D58P-Y89A-M216L, D58P-M117A-M216A, D58P-M117A-M216F, D58P-M117A-M216L, D58P-M117F-M216A, D58P-M117F-M216F, D58P-M117F-M216L, D58P- M117I-M216A, D58P-M117I-M216F, D58P-M117I-M216L, D58P-M117L-M216A, D58P-M117L- M216F, D58P-M117L-M216L, D58P-M117V-M216A, D58P-M117V-M216F, D58P-M117V-M216L, Y89A, Y89A-M117A, Y89A-M117F, Y89A-M1171, Y89A-M117L, Y89A-M117V, Y89A-M216A, Y89A- M216F, Y89A-M216L, Y89A-M117A-M216A, Y89A-M117A-M216F, Y89A-M117A-M216L, Y89A- M117F-M216A, Y89A-M117F-M216F, Y89A-M117F-M216L, Y89A-M117I-M216A, Y89A-M117I- M216F, Y89A-M117I-M216L, Y89A-M117L-M216A, Y89A-M117L-M216F, Y89A-M117L-M216L, Y89A-M117V-M216A, Y89A-M117V-M216F, Y89A-M117V-M216L, M117A, M117F, M117I, M117L, M117V, M117A-M216A, M117A-M216F, M117A-M216L, M117F-M216A, M117F-M216F, M117F- M216L, M117I-M216A, M117I-M216F, M117I-M216L, M117L-M216A, M117L-M216F, M117L-M216L,M117V-M216A, M117V-M216F, M117V-M216L, M216A, M216F, M216L existing group.,

[0058] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, (i) an amino acid substitution or amino acid substitution combination selected from the group consisting of I43V, M122L-N154S-T156A, M211 N-P212D, M211 L-P212D, G160S, D127P-M211 L-P212D, P212H and Q12L-M122L-A222S, and (ii) an amino acid substitution orAn amino acid substitution combination selected from the group consisting of M117A, M117A-Y89L, M117V, M117V-A29G, M117F, M117I, M117L, M216F, D58P- M216A, M216L.

[0059] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which is selected from the group consisting of I43V-A29G, I43V-A29G-D58P, I43V-A29G-Y89A, I43V-A29G-M117A, I43V-A29G-M117F, I43V-A29G-M117I, I43V-A29G-M117L, I43V-A29G-M117V, I43V-A29G-M216A, I43V-A29G-M216F, I43V-A29G-M216L, I43V-A29G-D58P-Y89A, I43V-A29G-D58P-M117A, I43V-A29G-D58P-M117F, I43V-A29G-D58P-M117I, I43V-A29G-D58P-M117L, I43V-A29G-D58P-M117V, I43V-A29G-D58P-M216A, I43V-A29G-D58P-M216F,I43V-A29G-D58P-M216L, I43V-A29G-Y89A-M117A, I43V-A29G- Y89A-M117F, I43V-A29G-Y89A-M1171, I43V-A29G-Y89A-M117L, I43V-A29G-Y89A-M117V, I43V- A29G-Y89A-M216A, I43V-A29G-Y89A-M216F, I43V-A29G-Y89A-M216L, I43V-A29G-M117A-M216A, I43V-A29G-M117A-M216F, I43V-A29G-M117A-M216L, I43V-A29G-D58P-Y89A-M117A, I43V-A29G- D58P-Y89A-M117F, I43V-A29G-D58P-Y89A-M1171, I43V-A29G-D58P-Y89A-M117L, I43V-A29G- D58P-Y89A-M117V, I43V-A29G-D58P-Y89A-M216A, I43V-A29G-D58P-Y89A-M216F, I43V-A29G- D58P-Y89A-M216L, I43V-A29G-Y89A-M117A-M216A, I43V-A29G-Y89A-M117A-M216F, I43V-A29G- Y89A-M117A-M216L, I43V-A29G-Y89A-M117F-M216A, I43V-A29G-Y89A-M117F-M216F, I43V- A29G-Y89A-M117F-M216L, I43V-A29G-Y89A-M117I-M216A, I43V-A29G-Y89A-M117I-M216F, I43V- A29G-Y89A-M117I-M216L, I43V-A29G-Y89A-M117L-M216A, I43V-A29G-Y89A-M117L-M216F, I43V- A29G-Y89A-M117L-M216L, I43V-A29G-Y89A-M117V-M216A, I43V-A29G-Y89A-M117V-M216F, I43V-A29G-Y89A-M117V-M216L, I43V-D58P, I43V-D58P-Y89A, I43V-D58P-M117A, I43V-D58P- M117F, I43V-D58P-M1171,I43V-D58P-M117L, I43V-D58P-M117V, I43V-D58P-M216A, I43V-D58P- M216F, I43V-D58P-M216L, I43V-D58P-Y89A-M117A, I43V-D58P-Y89A-M117F, I43V-D58P-Y89A- M117I, I43V-D58P-Y89A-M117L, I43V-D58P-Y89A-M117V, I43V-D58P-Y89A-M216A, I43V-D58P- Y89A-M216F, I43V-D58P-Y89A-M216L, I43V-D58P-M117A-M216A, I43V-D58P-M117A-M216F, I43V- D58P-M117A-M216L, I43V-D58P-M117F-M216A, I43V-D58P-M117F-M216F, I43V-D58P-M117F- M216L, I43V-D58P-M117I-M216A, I43V-D58P-M117I-M216F, I43V-D58P-M117I-M216L, I43V-D58P- M117L-M216A, I43V-D58P-M117L-M216F, I43V-D58P-M117L-M216L, I43V-D58P-M117V-M216A, I43V-D58P-M117V-M216F, I43V-D58P-M117V-M216L, I43V-Y89A, I43V-Y89A-M117A, I43V-Y89A- M117F, I43V-Y89A-M1171, I43V-Y89A-M117L, I43V-Y89A-M117V, I43V-Y89A-M216A, I43V-Y89A- M216F, I43V-Y89A-M216L, I43V-Y89A-M117A-M216A, I43V-Y89A-M117A-M216F, I43V-Y89A- M117A-M216L, I43V-Y89A-M117F-M216A, I43V-Y89A-M117F-M216F, I43V-Y89A-M117F-M216L, I43V-Y89A-M117I-M216A, I43V-Y89A-M117I-M216F, I43V-Y89A-M117I-M216L, I43V-Y89A-M117L- M216A,I43V-Y89A-M117L-M216F, I43V-Y89A-M117L-M216L, I43V-Y89A-M117V-M216A, I43V- Y89A-M117V-M216F, I43V-Y89A-M117V-M216L, I43V-M117A, I43V-M117F, I43V-M1171, I43V- M117L, I43V-M117V, I43V-M117A-M216A, I43V-M117A-M216F, I43V-M117A-M216L, I43V-M117F- M216A, I43V-M117F-M216F, I43V-M117F-M216L, I43V-M117I-M216A, I43V-M117I-M216F, I43V- M117I-M216L, I43V-M117L-M216A, I43V-M117L-M216F, I43V-M117L-M216L, I43V-M117V-M216A, I43V-M117V-M216F, I43V-M117V-M216L, I43V-M216A, I43V-M216F, I43V-M216L, M122L-N154S- T156A-A29G, M122L-N154S-T156A-A29G-D58P, M122L-N154S-T156A-A29G-Y89A, M122L-N154S- T156A-A29G-M117A, M122L-N154S-T156A-A29G-M117F, M122L-N154S-T156A-A29G-M1171, M122L-N154S-T156A-A29G-M117L, M122L-N154S-T156A-A29G-M117V, M122L-N154S-T156A- A29G-M216A, M122L-N154S-T156A-A29G-M216F, M122L-N154S-T156A-A29G-M216L, M122L- N154S-T156A-A29G-D58P-Y89A, M122L-N154S-T156A-A29G-D58P-M117A, M122L-N154S-T156A- A29G-D58P-M117F, M122L-N154S-T156A-A29G-D58P-M117I, M122L-N154S-T156A-A29G-D58P- M117L,M122L-N154S-T156A-A29G-D58P-M117V, M122L-N154S-T156A-A29G-D58P-M216A, M122L-N154S-T156A-A29G-D58P-M216F, M122L-N154S-T156A-A29G-D58P-M216L, M122L- N154S-T156A-A29G-Y89A-M117A, M122L-N154S-T156A-A29G-Y89A-M117F, M122L-N154S- T156A-A29G-Y89A-M117I, M122L-N154S-T156A-A29G-Y89A-M117L, M122L-N154S-T156A-A29G- Y89A-M117V, M122L-N154S-T156A-A29G-Y89A-M216A, M122L-N154S-T156A-A29G-Y89A-M216F, M122L-N154S-T156A-A29G-Y89A-M216L, M122L-N154S-T156A-A29G-M117A-M216A, M122L- N154S-T156A-A29G-M117A-M216F, M122L-N154S-T156A-A29G-M117A-M216L, M122L-N154S- T156A-A29G-D58P-Y89A-M117A, M122L-N154S-T156A-A29G-D58P-Y89A-M117F, M122L-N154S- T156A-A29G-D58P-Y89A-M1171, M122L-N154S-T156A-A29G-D58P-Y89A-M117L, M122L-N154S- T156A-A29G-D58P-Y89A-M117V, M122L-N154S-T156A-A29G-D58P-Y89A-M216A, M122L-N154S- T156A-A29G-D58P-Y89A-M216F, M122L-N154S-T156A-A29G-D58P-Y89A-M216L, M122L-N154S- T156A-A29G-Y89A-M117A-M216A, M122L-N154S-T156A-A29G-Y89A-M117A-M216F, M122L- N154S-T156A-A29G-Y89A-M117A-M216L,M122L-N154S-T156A-A29G-Y89A-M117F-M216A, M122L-N154S-T156A-A29G-Y89A-M117F-M216F, M122L-N154S-T156A-A29G-Y89A-M117F- M216L, M122L-N154S-T156A-A29G-Y89A-M117I-M216A, M122L-N154S-T156A-A29G-Y89A-M117I- M216F, M122L-N154S-T156A-A29G-Y89A-M117I-M216L, M122L-N154S-T156A-A29G-Y89A-M117L- M216A, M122L-N154S-T156A-A29G-Y89A-M117L-M216F, M122L-N154S-T156A-A29G-Y89A- M117L-M216L, M122L-N154S-T156A-A29G-Y89A-M117V-M216A, M122L-N154S-T156A-A29G- Y89A-M117V-M216F, M122L-N154S-T156A-A29G-Y89A-M117V-M216L, M122L-N154S-T156A- D58P, M122L-N154S-T156A-D58P-Y89A, M122L-N154S-T156A-D58P-M117A, M122L-N154S- T156A-D58P-M117F, M122L-N154S-T156A-D58P-M1171, M122L-N154S-T156A-D58P-M117L, M122L-N154S-T156A-D58P-M117V, M122L-N154S-T156A-D58P-M216A, M122L-N154S-T156A- D58P-M216F, M122L-N154S-T156A-D58P-M216L, M122L-N154S-T156A-D58P-Y89A-M117A, M122L-N154S-T156A-D58P-Y89A-M117F, M122L-N154S-T156A-D58P-Y89A-M117I, M122L-N154S- T156A-D58P-Y89A-M117L, M122L-N154S-T156A-D58P-Y89A-M117V,M122L-N154S-T156A-D58P- Y89A-M216A, M122L-N154S-T156A-D58P-Y89A-M216F, M122L-N154S-T156A-D58P-Y89A-M216L, M122L-N154S-T156A-D58P-M117A-M216A, M122L-N154S-T156A-D58P-M117A-M216F, M122L- N154S-T156A-D58P-M117A-M216L, M122L-N154S-T156A-D58P-M117F-M216A, M122L-N154S- T156A-D58P-M117F-M216F, M122L-N154S-T156A-D58P-M117F-M216L, M122L-N154S-T156A- D58P-M117I-M216A, M122L-N154S-T156A-D58P-M117I-M216F, M122L-N154S-T156A-D58P- M117I-M216L, M122L-N154S-T156A-D58P-M117L-M216A, M122L-N154S-T156A-D58P-M117L- M216F, M122L-N154S-T156A-D58P-M117L-M216L, M122L-N154S-T156A-D58P-M117V-M216A, M122L-N154S-T156A-D58P-M117V-M216F, M122L-N154S-T156A-D58P-M117V-M216L, M122L- N154S-T156A-Y89A, M122L-N154S-T156A-Y89A-M117A, M122L-N154S-T156A-Y89A-M117F, M122L-N154S-T156A-Y89A-M117I, M122L-N154S-T156A-Y89A-M117L, M122L-N154S-T156A- Y89A-M117V, M122L-N154S-T156A-Y89A-M216A, M122L-N154S-T156A-Y89A-M216F, M122L- N154S-T156A-Y89A-M216L, M122L-N154S-T156A-Y89A-M117A-M216A, M122L-N154S-T156A- Y89A-M117A-M216F,M122L-N154S-T156A-Y89A-M117A-M216L, M122L-N154S-T156A-Y89A- M117F-M216A, M122L-N154S-T156A-Y89A-M117F-M216F, M122L-N154S-T156A-Y89A-M117F- M216L, M122L-N154S-T156A-Y89A-M117I-M216A, M122L-N154S-T156A-Y89A-M117I-M216F, M122L-N154S-T156A-Y89A-M117I-M216L, M122L-N154S-T156A-Y89A-M117L-M216A, M122L- N154S-T156A-Y89A-M117L-M216F, M122L-N154S-T156A-Y89A-M117L-M216L, M122L-N154S- T156A-Y89A-M117V-M216A, M122L-N154S-T156A-Y89A-M117V-M216F, M122L-N154S-T156A- Y89A-M117V-M216L, M122L-N154S-T156A-M117A, M122L-N154S-T156A-M117F, M122L-N154S- T156A-M117I, M122L-N154S-T156A-M117L, M122L-N154S-T156A-M117V, M122L-N154S-T156A- M117A-M216A, M122L-N154S-T156A-M117A-M216F, M122L-N154S-T156A-M117A-M216L, M122L- N154S-T156A-M117F-M216A, M122L-N154S-T156A-M117F-M216F, M122L-N154S-T156A-M117F- M216L, M122L-N154S-T156A-M117I-M216A, M122L-N154S-T156A-M117I-M216F, M122L-N154S- T156A-M117I-M216L, M122L-N154S-T156A-M117L-M216A, M122L-N154S-T156A-M117L-M216F, M122L-N154S-T156A-M117L-M216L,M122L-N154S-T156A-M117V-M216A, M122L-N154S-T156A- M117V-M216F, M122L-N154S-T156A-M117V-M216L, M122L-N154S-T156A-M216A, M122L-N154S- T156A-M216F, M122L-N154S-T156A-M216L, M211 N-P212D-A29G, M211 N-P212D-A29G-D58P, M211 N-P212D-A29G-Y89A, M211 N-P212D-A29G-M117A, M211 N-P212D-A29G-M117F, M211 N- P212D-A29G-M1171, M211 N-P212D-A29G-M117L, M211 N-P212D-A29G-M117V, M211 N-P212D- A29G-M216A, M211 N-P212D-A29G-M216F, M211 N-P212D-A29G-M216L, M211 N-P212D-A29G- D58P-Y89A, M211 N-P212D-A29G-D58P-M117A, M211 N-P212D-A29G-D58P-M117F, M211 N- P212D-A29G-D58P-M1171, M211 N-P212D-A29G-D58P-M117L, M211 N-P212D-A29G-D58P-M117V, M211 N-P212D-A29G-D58P-M216A, M211 N-P212D-A29G-D58P-M216F, M211 N-P212D-A29G- D58P-M216L, M211 N-P212D-A29G-Y89A-M117A, M211 N-P212D-A29G-Y89A-M117F, M211 N- P212D-A29G-Y89A-M117I, M211 N-P212D-A29G-Y89A-M117L, M211 N-P212D-A29G-Y89A-M117V, M211 N-P212D-A29G-Y89A-M216A, M211 N-P212D-A29G-Y89A-M216F, M211 N-P212D-A29G-Y89A- M216L, M211 N-P212D-A29G-M117A-M216A,M211 N-P212D-A29G-M117A-M216F, M211 N-P212D- A29G-M117A-M216L, M211 N-P212D-A29G-D58P-Y89A-M117A, M211 N-P212D-A29G-D58P-Y89A- M117F, M211 N-P212D-A29G-D58P-Y89A-M117I, M211 N-P212D-A29G-D58P-Y89A-M117L, M211 N- P212D-A29G-D58P-Y89A-M117V, M211 N-P212D-A29G-D58P-Y89A-M216A, M211 N-P212D-A29G- D58P-Y89A-M216F, M211 N-P212D-A29G-D58P-Y89A-M216L, M211 N-P212D-A29G-Y89A-M117A- M216A, M211 N-P212D-A29G-Y89A-M117A-M216F, M211 N-P212D-A29G-Y89A-M117A-M216L, M211 N-P212D-A29G-Y89A-M117F-M216A, M211 N-P212D-A29G-Y89A-M117F-M216F, M211 N- P212D-A29G-Y89A-M117F-M216L, M211 N-P212D-A29G-Y89A-M117I-M216A, M211 N-P212D-A29— Y89A-M117I-M216F, M211 N-P212D-A29G-Y89A-M117I-M216L, M211 N-P212D-A29G-Y89A-M117L- M216A, M211 N-P212D-A29G-Y89A-M117L-M216F, M211 N-P212D-A29G-Y89A-M117L-M216L, M211 N-P212D-A29G-Y89A-M117V-M216A, M211 N-P212D-A29G-Y89A-M117V-M216F, M211 N- P212D-A29— Y89A-M117V-M216L, M211 N-P212D-D58P, M211 N-P212D-D58P-Y89A, M211 N- P212D-D58P-M117A, M211 N-P212D-D58P-M117F,M211 N-P212D-D58P-M117I, M211 N-P212D- D58P-M117L, M211 N-P212D-D58P-M117V, M211 N-P212D-D58P-M216A, M211 N-P212D-D58P- M216F, M211 N-P212D-D58P-M216L, M211N-P212D-D58P-Y89A-M117A, M211 N-P212D-D58P- Y89A-M117F, M211 N-P212D-D58P-Y89A-M117I, M211 N-P212D-D58P-Y89A-M117L, M211 N- P212D-D58P-Y89A-M117V, M211 N-P212D-D58P-Y89A-M216A, M211 N-P212D-D58P-Y89A-M216F, M211 N-P212D-D58P-Y89A-M216L, M211 N-P212D-D58P-M117A-M216A, M211 N-P212D-D58P- M117A-M216F, M211 N-P212D-D58P-M117A-M216L, M211 N-P212D-D58P-M117F-M216A, M211 N- P212D-D58P-M117F-M216F, M211 N-P212D-D58P-M117F-M216L, M211 N-P212D-D58P-M1171- M216A, M211 N-P212D-D58P-M117I-M216F, M211 N-P212D-D58P-M117I-M216L, M211 N-P212D- D58P-M117L-M216A, M211 N-P212D-D58P-M117L-M216F, M211 N-P212D-D58P-M117L-M216L, M211 N-P212D-D58P-M117V-M216A, M211 N-P212D-D58P-M117V-M216F, M211 N-P212D-D58P- M117V-M216L, M211 N-P212D-Y89A, M211 N-P212D-Y89A-M117A, M211 N-P212D-Y89A-M117F, M211 N-P212D-Y89A-M117I, M211 N-P212D-Y89A-M117L,<h2 style=";text-align:left;direction:ltr">M211 N-P212D-Y89A-M117V, M211 N-P212D-Y89A-M216A, M211 N-P212D-Y89A-M216F, M211 N-P212D-Y89A-M216L, M211 N-P212D-Y89A-M117A-M216A, M211 N-P212D-Y89A-M117A-M216F, M211 N-P212D-Y89A-M117A-M216L, M211 N-P212D-Y89A-M117F-M216A, M211 N-P212D-Y89A-M117F-M216F, M211 N-P212D-Y89A-M117F-M216L, M211 N-P212D-Y89A-M117I-M216A, M211 N-P212D-Y89A-M117I-M216F, M211 N-P212D-Y89A-M117I-M216L, M211 N-P212D-Y89A-M117L-M216A, M211 N-P212D-Y89A-M117L-M216F, M211 N-P212D-Y89A-M117L-M216L, M211 N-P212D-Y89A-M117V-M216A, M211 N-P212D- M211 N-P212D-M117I M211 N-P212D- N-P212D-M117L, M211 N-P212D-M117V, M211 N-P212D- M117A-M216A, M211 N-P212D-M117A-M216F, M117F-M216A, M211 N-P212D-M117F-M216F, M211 N-P212D-M117F-M216L, M211 N-P212D-M1171- M216A, M211 N-P212D-M117I-M216F, M211 N-P212D-M117I-M216L, M211 N-P212D-M117L-M216A, M211 N-P212D-M117L-M216F, M211 N-P212D-M117L-M216L,M211 N-P212D-M117V-M216A, M211 N-P212D-M117V-M216F, M211 N-P212D-M117V-M216L, M211 N-P212D-M216A, M211 N- P212D-M216F, M211 N-P212D-M216L, M211 L-P212D-A29G, M211 L-P212D-A29G-D58P, M211 L- P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D- A29G-M117I, M211 L-P212D-A29G-M117L, M211 L-P212D-A29G-M117V, M211 L-P212D-A29G- M216A, M211 L-P212D-A29G-M216F, M211 L-P212D-A29G-M216L, M211 L-P212D-A29G-D58P- Y89A, M211 L-P212D-A29G-D58P-M117A, M211 L-P212D-A29G-D58P-M117F, M211 L-P212D-A29G- D58P-M1171, M21 1 L-P212D-A29G-D58P-M117L, M211 L-P212D-A29G-D58P-M117V, M211 L-P212D- A29G-D58P-M216A, M211 L-P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P-M216L, M211 L- P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D-A29G-Y89A-M1171, M211 L-P212D-A29G-Y89A-M117L, M21 1 L-P212D-A29G-Y89A-M117V, M211 L-P212D-A29G-Y89A- M216A, M211 L-P212D-A29G-Y89A-M216F, M211 L-P212D-A29G-Y89A-M216L, M211 L-P212D- A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F,M211 L-P212D-A29G-M117A-M216L, M21 1 L-P212D-A29G-D58P-Y89A-M117A, M211 L-P212D-A29G-D58P-Y89A-M117F, M211 L-P212D- A29G-D58P-Y89A-M117I , M211 L-P212D-A29G-D58P-Y89A-M117L, M211 L-P212D-A29G-D58P- Y89A-M117V, M211 L-P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P-Y89A-M216F, M211 L-P212D-A29G-D58P-Y89A-M216L, M211 L-P212D-A29G-Y89A-M117A-M216A, M211 L- P212D-A29G-Y89A-M117A-M216F, M211 L-P212D-A29G-Y89A-M117A-M216L, M211 L-P212D- A29G-Y89A-M117F-M216A, M211 L-P212D-A29G-Y89A-M117F-M216F, M211 L-P212D-A29G-Y89A- M1 17F-M216L, M21 1 L-P212D-A29G-Y89A-M117I-M216A, M21 1 L-P212D-A29G-Y89A-M1 17I-M216F, M211 L-P212D-A29G-Y89A-M117I-M216L, M211 L-P212D-A29G-Y89A-M117L-M216A, M211 L- P212D-A29G-Y89A-M117L-M216F, M211 L-P212D-A29G-Y89A-M117L-M216L, M211 L-P212D-A29G- Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V-M216F, M21 1 L-P212D-A29G-Y89A- M117V-M216L, M211 L-P212D-D58P, M211 L-P212D-D58P-Y89A, M211 L-P212D-D58P-M117A, M21 1 L-P212D-D58P-M117F, M211 L-P212D-D58P-M117I,M211 L-P212D-D58P-M1 17L, M211 L- P212D-D58P-M117V, M211 L-P212D-D58P-M216A, M211 L-P212D-D58P-M216F, M211 L-P212D- D58P-M216L, M211 L-P212D-D58P-Y89A-M1 17A, M211 L-P212D-D58P-Y89A-M117F, M211 L- P212D-D58P-Y89A-M1 171, M21 1 L-P212D-D58P-Y89A-M117L, M21 1 L-P212D-D58P-Y89A-M117V, M211 L-P212D-D58P-Y89A-M216A, M211 L-P212D-D58P-Y89A-M216F, M211 L-P212D-D58P-Y89A- M216L, M211 L-P212D-D58P-M117A-M216A, M211 L-P212D-D58P-M1 17A-M216F, M211 L-P212D- D58P-M1 17A-M216L, M211 L-P212D-D58P-M117F-M216A, M21 1 L-P212D-D58P-M1 17F-M216F, M211 L-P212D-D58P-M117F-M216L, M211 L-P212D-D58P-M1 17I-M216A, M211 L-P212D-D58P- M1 17I-M216F, M211 L-P212D-D58P-M1 17I-M216L, M211 L-P212D-D58P-M117L-M216A, M211 L- P212D-D58P-M117L-M216F, M211 L-P212D-D58P-M117L-M216L, M211 L-P212D-D58P-M117V- M216A, M211 L-P212D-D58P-M117V-M216F, M211 L-P212D-D58P-M117V-M216L, M211 L-P212D- Y89A, M211 L-P212D-Y89A-M1 17A, M211 L-P212D-Y89A-M117F, M211 L-P212D-Y89A-M117I, M21 1 L-P212D-Y89A-M117L, M211 L-P212D-Y89A-M117V,M211 L-P212D-Y89A-M216A, M211 L- P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L, M211 L-P212D-Y89A-M117A-M216A, M211 L- P212D-Y89A-M117A-M216F, M21 1 L-P212D-Y89A-M1 17A-M216L, M211 L-P212D-Y89A-M117F- M216A, M211 L-P212D-Y89A-M117F-M216F, M211 L-P212D-Y89A-M117F-M216L, M211 L-P212D- Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A-M117L-M216A, M211 L-P212D-Y89A-M117L-M216F, M211 L-P212D-Y89A- M1 17L-M216L, M211 L-P212D-Y89A-M117V-M216A, M21 1 L-P212D-Y89A-M117V-M216F, M211 L- P212D-Y89A-M117V-M216L, M211 L-P212D-M117A, M211 L-P212D-M117F, M211 L-P212D-M117I, M21 1 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L-P212D-M117A- M216F, M211 L-P212D-M117A-M216L, M211 L-P212D-M117F-M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L- P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L-P212D-M117L-M216F, M211 L-P212D- M117L-M216L, M211 L-P212D-M117V-M216A,M211 L-P212D-M117V-M216F, M211 L-P212D-M117V- M216L, M211 L-P212D-M216A, M211 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L-P212D-A29G-M117A-M216F, D127P-M211 L-P212D- A29G-M117A-M216L, D127P-M211 L-P212D-A29G-D58P-Y89A-M117A, D127P-M211 L-P212D- A29G-D58P-Y89A-M117F, D127P-M211 L-P212D-A29G-D58P-Y89A-M1171, D127P-M211 L-P212D- A29G-D58P-Y89A-M117L, D127P-M211 L-P212D-A29G-D58P-Y89A-M117V, D127P-M211 L-P212D- A29G-D58P-Y89A-M216A, D127P-M211 L-P212D-A29G-D58P-Y89A-M216F, D127P-M211 L-P212D- A29G-D58P-Y89A-M216L, D127P-M211 L-P212D-A29G-Y89A-M117A-M216A, D127P-M211 L- P212D-A29G-Y89A-M117A-M216F, D127P-M211 L-P212D-A29G-Y89A-M117A-M216L, D127P- M211 L-P212D-A29G-Y89A-M117F-M216A, D127P-M211 L-P212D-A29G-Y89A-M117F-M216F, D127P-M211 L-P212D-A29G-Y89A-M117F-M216L, D127P-M211 L-P212D-A29G-Y89A-M117I-M216A, D127P-M211 L-P212D-A29— Y89A-M117I-M216F, D127P-M211 L-P212D-A29G-Y89A-M117I-M216L, D127P-M211 L-P212D-A29G-Y89A-M117L-M216A, D127P-M211 L-P212D-A29G-Y89A-M117L- M216F,D127P-M211 L-P212D-A29G-Y89A-M117L-M216L, D127P-M211 L-P212D-A29G-Y89A- M117V-M216A, D127P-M211 L-P212D-A29G-Y89A-M117V-M216F, D127P-M211 L-P212D-A29G- Y89A-M117V-M216L, D127P-M211 L-P212D-D58P, D127P-M211 L-P212D-D58P-Y89A, D127P- M211 L-P212D-D58P-M117A, D127P-M211 L-P212D-D58P-M117F, D127P-M211 L-P212D-D58P- M117I, D127P-M211 L-P212D-D58P-M117L, D127P-M211 L-P212D-D58P-M117V, D127P-M211 L- P212D-D58P-M216A, D127P-M211 L-P212D-D58P-M216F, D127P-M211 L-P212D-D58P-M216L, D127P-M211 L-P212D-D58P-Y89A-M117A, D127P-M211 L-P212D-D58P-Y89A-M117F, D127P-,

[0060] M211 L-P212D-D58P-Y89A-M1171, D127P-M211 L-P212D-D58P-Y89A-M117L, D127P-M211 L-P212D- D58P-Y89A-M117V, D127P-M211 L-P212D-D58P-Y89A-M216A, D127P-M211 L-P212D-D58P-Y89A- M216F, D127P-M211 L-P212D-D58P-Y89A-M216L, D127P-M211 L-P212D-D58P-M117A-M216A, D127P-M211 L-P212D-D58P-M117A-M216F, D127P-M211 L-P212D-D58P-M117A-M216L, D127P- M211 L-P212D-D58P-M117F-M216A, D127P-M211 L-P212D-D58P-M117F-M216F, D127P-M211 L- P212D-D58P-M117F-M216L, D127P-M211 L-P212D-D58P-M117I-M216A, D127P-M211 L-P212D- D58P-M117I-M216F, D127P-M211 L-P212D-D58P-M117I-M216L, D127P-M211 L-P212D-D58P- M117L-M216A, D127P-M211 L-P212D-D58P-M117L-M216F, D127P-M211 L-P212D-D58P-M117L- M216L, D127P-M211 L-P212D-D58P-M117V-M216A, D127P-M211 L-P212D-D58P-M117V-M216F, D127P-M211 L-P212D-D58P-M117V-M216L, D127P-M211 L-P212D-Y89A, D127P-M211 L-P212D- Y89A-M117A, D127P-M211 L-P212D-Y89A-M117F, D127P-M211 L-P212D-Y89A-M1171, D127P- M211 L-P212D-Y89A-M117L, D127P-M211 L-P212D-Y89A-M117V, D127P-M211 L-P212D-Y89A- M216A,<h2 style=";text-align:left;direction:ltr">D127P-M211 L-P212D-Y89A-M216F, D127P-M211 L-P212D-Y89A-M216L, D127P-M211 L- P212D-Y89A-M117A-M216A, D127P-M211 L-P212D-Y89A-M117A-M216F, D127P-M211 L-P212D- Y89A-M117A-M216L, D127P-M211 L-P212D-Y89A-M117F-M216A, D127P-M211 L-P212D-Y89A- M117F-M216F, D127P-M211 L-P212D-Y89A-M117F-M216L, D127P-M211 L-P212D-Y89A-M1171- M216A, D127P-M211 L-P212D-Y89A-M117I-M216F, D127P-M211 L-P212D-Y89A-M117I-M216L, D127P-M211 L-P212D-Y89A-M117L-M216A, D127P-M211 L-P212D-Y89A-M117L-M216F, D127P- M211 L-P212D-Y89A-M117L-M216L, D127P-M211 L-P212D-Y89A-M117V-M216A, D127P-M211 L- P212D-Y89A-M117V-M216F, D127P-M211 L-P212D-Y89A-M117V-M216L, L-P212D- D127P-M211 M117A, D127P-M211 L-P212D-M117F, D127P-M211 L-P212D-M1171, D127P-M211 L-P212D-M117L, D127P-M211 L-P212D-M117A-M216A, D127P-M211 L-P212D-M117A- M216F, D127P-M211 L-P212D-M117A-M216L, D127P-M211 L-P212D-M117F-M216A, D127P-M211 L- P212D-M117F-M216F, D127P-M211 L-P212D-M117F-M216L, D127P-M211 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P212H-M117A-M216A,<h2 style=";text-align:left;direction:ltr">P212H-M117A-M216F, P212H-M117A-M216L, P212H-M117F-M216A, P212H-M117F-M216F, P212H-M117F-M216L, P212H-M117I-M216A, P212H-M117I-M216F, P212H- M117I-M216L, P212H-M117L-M216A, P212H-M117L-M216F, P212H-M117L-M216L, P212H-M117V- M216A, P212H-M117V-M216F, P212H-M117V-M216L, P212H-M216A, P212H-M216F, P212H-M216L, Q12L-M122L-A222S-A29G, Q12L-M122L-A222S-A29G-D58P, Q12L-M122L-A222S-A29G-Y89A, Q12L-M122L-A222S-A29G-M117A, Q12L-M122L-A222S-A29G-M117F, Q12L-M122L-A222S-A29G-M117I, Q12L-M122L-A222S-A29G-M117L, Q12L-M122L-A222S-A29G-M117V, Q12L-M122L- A222S-A29G-M216A, Q12L-M122L-A222S-A29G-M216F, Q12L-M122L-A222S-A29G-M216L, Q12L- M122L-A222S-A29G-D58P-Y89A, Q12L-M122L-A222S-A29G-D58P-M117A, Q12L-M122L-A222S- A29G-D58P-M117F, Q12L-M122L-A222S-A29G-D58P-M117I, Q12L-M122L-A222S-A29G-D58P-M117L, Q12L-M122L-A222S-A29G-D58P-M117V, Q12L-M122L-A222S-A29G-D58P-M216A, Q12L- M122L-A222S-A29G-D58P-M216F, Q12L-M122L-A222S-A29G-D58P-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A, Q12L-M122L-A222S-A29G-Y89A-M117F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117I, Q12L-M122L-A222S-A29G-Y89A-M117L, Q12L-M122L-A222S-A29G-Y89A-M117V, Q12L- M122L-A222S-A29G-Y89A-M216A, Q12L-M122L-A222S-A29G-Y89A-M216F, Q12L-M122L-A222S-A29G-Y89A-M216L, Q12L-M122L-A222S-A29G-M117A-M216A, Q12L-M122L-A222S-A29G-M117A-M216F, Q12L-M122L-A222S-A29G-M117A-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117A, Q12L-M122L-A222S-A29G-D58P-Y89A-M117F, Q12L-M122L-A222S-A29G-D58P-Y89A-M1171, Q12L-M122L-A222S-A29G-D58P-Y89A-M117L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117V, Q12L-M122L-A222S-A29G-D58P-Y89A-M216A, Q12L-M122L-A222S-A29G-D58P-Y89A-M216F, Q12L-M122L-A222S-A29G-D58P-Y89A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A-M216A, Q12L-M122L-A222S-A29G-Y89A-M117A-M216F, Q12L-M122L-A222S-A29G-Y89A-M117A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117F-M216A, Q12L-M122L-A222S-A29G-Y89A-M117F-M216F, Q12L-M122L-A222S-A29G-Y89A-M117F-M216L, Q12L-M122L-A222S-A29G-Y89A-M117I-M216A, Q12L-M122L-A222S-A29G-Y89A-M117I-M216F, Q12L-M122L-A222S-A29G-Y89A-M117I-M216L,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117L-M216A, Q12L-M122L-A222S-A29G-Y89A-M117L-M216F, Q12L-M122L-A222S-A29G-Y89A-M117L-M216L, Q12L-M122L-A222S-A29G-Y89A-M117V-M216A, Q12L-M122L-A222S-A29G-Y89A-M117V-M216F, Q12L-M122L-A222S-A29G-Y89A-M117V-M216L, Q12L-M122L-A222S-D58P, Q12L-M122L-A222S-D58P-Y89A, Q12L-M122L-A222S-D58P-M117A, Q12L-M122L-A222S-D58P-M117F, Q12L-M122L-A222S-D58P-M1171, Q12L-M122L-A222S-D58P- M117L, Q12L-M122L-A222S-D58P-M117V, Q12L-M122L-A222S-D58P-M216A, Q12L-M122L-A222S- D58P-M216F, Q12L-M122L-A222S-D58P-M216L, Q12L-M122L-A222S-D58P-Y89A-M117A, Q12L- M122L-A222S-D58P-Y89A-M117F, Q12L-M122L-A222S-D58P-Y89A-M1171, Q12L-M122L-A222S- D58P-Y89A-M117L, Q12L-M122L-A222S-D58P-Y89A-M117V, Q12L-M122L-A222S-D58P-Y89A-M216A, Q12L-M122L-A222S-D58P-Y89A-M216F, Q12L-M122L-A222S-D58P-Y89A-M216L, Q12L- M122L-A222S-D58P-M117A-M216A, Q12L-M122L-A222S-D58P-M117A-M216F, Q12L-M122L- A222S-D58P-M117A-M216L, Q12L-M122L-A222S-D58P-M117F-M216A, Q12L-M122L-A222S-D58P- M117F-M216F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-D58P-M117F-M216L, Q12L-M122L-A222S-D58P-M1171- M216A, Q12L-M122L-A222S-D58P-M117I-M216F, Q12L-M122L-A222S-D58P-M117I-M216L, Q12L- M122L-A222S-D58P-M117L-M216A, Q12L-M122L-A222S-D58P-M117L-M216F, Q12L-M122L- A222S-D58P-M117L-M216L, Q12L-M122L-A222S-D58P-M117V-M216A, Q12L-M122L-A222S-D58P-M117V-M216F, Q12L-M122L-A222S-D58P-M117V-M216L, Q12L-M122L-A222S-Y89A, Q12L-M122L-A222S-Y89A-M117A, Q12L-M122L-A222S-Y89A-M117F, Q12L-M122L-A222S-Y89A-M1171, Q12L-M122L-A222S-Y89A-M117L, Q12L-M122L-A222S-Y89A-M117V, Q12L-M122L-A222S-Y89A-M216A, Q12L-M122L-A222S-Y89A-M216F, Q12L-M122L-A222S-Y89A-M216L, Q12L-M122L-A222S-Y89A-M117A-M216A, Q12L-M122L-A222S-Y89A-M117A-M216F, Q12L-M122L-A222S-Y89A-M117A-M216L, Q12L-M122L-A222S-Y89A-M117F-M216A, Q12L-M122L-A222S-Y89A-M117F-M216F, Q12L- M122L-A222S-Y89A-M117F-M216L, Q12L-M122L-A222S-Y89A-M117I-M216A, Q12L-M122L-A222S-Y89A-M117I-M216F, Q12L-M122L-A222S-Y89A-M117I-M216L, Q12L-M122L-A222S-Y89A-M117L-M216A, Q12L-M122L-A222S-Y89A-M117L-M216F,Q12L-M122L-A222S-Y89A-M117L-M216L, Q12L- M122L-A222S-Y89A-M117V-M216A, Q12L-M122L-A222S-Y89A-M117V-M216F, Q12L-M122L- A222S-Y89A-M117V-M216L, Q12L-M122L-A222S-M117A, Q12L-M122L-A222S-M117F, Q12L-M122L-A222S-M1171, Q12L-M122L-A222S-M117L, Q12L-M122L-A222S-M117V, Q12L-M122L-A222S-M117A-M216A, Q12L-M122L-A222S-M117A-M216F, Q12L-M122L-A222S-M117A-M216L, Q12L-M122L-A222S-M117F-M216A, Q12L-M122L-A222S-M117F-M216F, Q12L-M122L-A222S-M117F-M216L, Q12L-M122L-A222S-M117I-M216A, Q12L-M122L-A222S-M117I-M216F, Q12L-M122L-A222S-M117I-M216L, Q12L-M122L-A222S-M117L-M216A, Q12L-M122L-A222S-M117L-M216F, Q12L-M122L-A222S-M117L-M216L, Q12L-M122L-A222S-M117V-M216A, Q12L-M122L-A222S-M117V-M216F, Q12L-M122L-A222S-M117V-M216L, Q12L-M122L-A222S-M216A, Q12L- M122L-A222S-M216F, Q12L-M122L-A222S-M216L existing group is selected.,

[0061] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which consists of the one selected from M211 L-P212D-A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L-P212D-A29G-M117V, M211 L-P212D-A29G-M216A, M211 L-P212D-A29G- M216F, M211 L-P212D-A29G-M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P- M117A,M211 L-P212D-A29G-D58P-M117F, M211 L-P212D-A29G-D58P-M117I, M211 L-P212D- A29G-D58P-M117L, M211 L-P212D-A29G-D58P-M117V, M211 L-P212D-A29G-D58P-M216A, M211 L- P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P-M216L, M211 L-P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D-A29G-Y89A-M117I, M211 L-P212D-A29G-Y89A- M117L, M211 L-P212D-A29G-Y89A-M117V, M211 L-P212D-A29G-Y89A-M216A, M211 L-P212D- A29G-Y89A-M216F, M211 L-P212D-A29G-Y89A-M216L, M211 L-P212D-A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F, M211 L-P212D-A29G-M117A-M216L, M211 L-P212D-A29G- D58P-Y89A-M117A, M211 L-P212D-A29G-D58P-Y89A-M117F, M211 L-P212D-A29G-D58P-Y89A- M117I, M211 L-P212D-A29G-D58P-Y89A-M117L, M211 L-P212D-A29G-D58P-Y89A-M117V, M211 L- P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P-Y89A-M216F, M211 L-P212D-A29G- D58P-Y89A-M216L, M211 L-P212D-A29G-Y89A-M117A-M216A, M211 L-P212D-A29G-Y89A-M117A- M216F, M211 L-P212D-A29G-Y89A-M117A-M216L, M211 L-P212D-A29G-Y89A-M117F-M216A,M211 L-P212D-A29G-Y89A-M117F-M216F, M211 L-P212D-A29G-Y89A-M117F-M216L, M211 L- P212D-A29G-Y89A-M117I-M216A, M211 L-P212D-A29G-Y89A-M117I-M216F, M211 L-P212D-A29G- Y89A-M117I-M216L, M211 L-P212D-A29G-Y89A-M117L-M216A, M211 L-P212D-A29G-Y89A-M117L- M216F, M211 L-P212D-A29G-Y89A-M117L-M216L, M211 L-P212D-A29G-Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V-M216F, M211 L-P212D-A29G-Y89A-M117V-M216L, M211 L- P212D-D58P, M211 L-P212D-D58P-Y89A, M211 L-P212D-D58P-M117A, M211 L-P212D-D58P- M117F, M211 L-P212D-D58P-M117I, M211 L-P212D-D58P-M117L, M211 L-P212D-D58P-M117V, M211 L-P212D-D58P-M216A, M211 L-P212D-D58P-M216F, M211 L-P212D-D58P-M216L, M211 L- P212D-D58P-Y89A-M117A, M211 L-P212D-D58P-Y89A-M117F, M211 L-P212D-D58P-Y89A-M1171, M211 L-P212D-D58P-Y89A-M117L, M211 L-P212D-D58P-Y89A-M117V, M211 L-P212D-D58P-Y89A- M216A, M211 L-P212D-D58P-Y89A-M216F, M211 L-P212D-D58P-Y89A-M216L, M211 L-P212D- D58P-M117A-M216A, M211 L-P212D-D58P-M117A-M216F, M211 L-P212D-D58P-M117A-M216L,M211 L-P212D-D58P-M117F-M216A, M211 L-P212D-D58P-M117F-M216F, M211 L-P212D-D58P- M117F-M216L, M211 L-P212D-D58P-M117I-M216A, M211 L-P212D-D58P-M117I-M216F, M211 L- P212D-D58P-M117I-M216L, M211 L-P212D-D58P-M117L-M216A, M211 L-P212D-D58P-M117L- M216F, M211 L-P212D-D58P-M117L-M216L, M211 L-P212D-D58P-M117V-M216A, M211 L-P212D- D58P-M117V-M216F, M211 L-P212D-D58P-M117V-M216L, M211 L-P212D-Y89A, M211 L-P212D- Y89A-M117A, M211 L-P212D-Y89A-M117F, M211 L-P212D-Y89A-M1171, M211 L-P212D-Y89A- M117L, M211 L-P212D-Y89A-M117V, M211 L-P212D-Y89A-M216A, M211 L-P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L, M211 L-P212D-Y89A-M117A-M216A, M211 L-P212D-Y89A-M117A- M216F, M211 L-P212D-Y89A-M117A-M216L, M211 L-P212D-Y89A-M117F-M216A, M211 L-P212D- Y89A-M117F-M216F, M211 L-P212D-Y89A-M117F-M216L, M211 L-P212D-Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A- M117L-M216A, M211 L-P212D-Y89A-M117L-M216F, M211 L-P212D-Y89A-M117L-M216L,M211 L-P212D-Y89A-M117V-M216A, M211 L-P212D-Y89A-M117V-M216F, M211 L-P212D-Y89A-M117V- M216L, M211 L-P212D-M117A, M211 L-P212D-M117F, M211 L-P212D-M117I, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L-P212D-M117A-M216F, M211 L-P212D- M117A-M216L, M211 L-P212D-M117F-M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L-P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L-P212D-M117L-M216F, M211 L-P212D-M117L-M216L, M211 L P212D-M117V-M216A, M211 L-P212D-M117V-M216F, M211 L-P212D-M117V-M216L, M211 L-P212D- M216A, M211 L-P212D-M216F, M211 L-P212D-M216L existing group is selected.,

[0062] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which is selected from the group consisting of M117A-M211 L-P212D, Y89A-M117A-M211 L-P212D, M117V-M211 L-P212D, A29G-M117V- M211 L-P212D, M117F-M211 L-P212D, M117I-M211 L-P212D, M117L-M211 L-P212D, M211 L-P212D- M216F, D58P-M211 L-P212D-M216A and M211 L-P212D-M216L existing group is selected.

[0063] In preferred embodiments, the protease according to the invention comprises an amino acid substitution combination selected from the group consisting of I43V-A29G, I43V-A29G-D58P, I43V-A29G-Y89A, I43V-A29G-M117A, I43V-A29G-M117F, I43V-A29G-M117I, I43V-A29G-M117L, I43V-A29G-M117V, I43V-A29G-M216A, I43V-A29G-M216F, I43V-A29G-M216L, I43V-A29G-D58P-Y89A, I43V-A29G-D58P-M117A, I43V-A29G-D58P-M117F, I43V-A29G-D58P-M1171, I43V-A29G-D58P-M117L, I43V-A29G-D58P-M117V, I43V-A29G-D58P-M216A, I43V-A29G-D58P-M216F, I43V-A29G-D58P- M216L, I43V-A29G-Y89A-M117A, I43V-A29G-Y89A-M117F, I43V-A29G-Y89A-M1171, I43V-A29G- Y89A-M117L, I43V-A29G-Y89A-M117V, I43V-A29G-Y89A-M216A, I43V-A29G-Y89A-M216F, I43V-A29G-Y89A-M216L, I43V-A29G-M117A-M216A, I43V-A29G-M117A-M216F, I43V-A29G-M117A- M216L, I43V-A29G-D58P-Y89A-M117A, I43V-A29G-D58P-Y89A-M117F, I43V-A29G-D58P-Y89A- M117I, I43V-A29G-D58P-Y89A-M117L, I43V-A29G-D58P-Y89A-M117V, I43V-A29G-D58P-Y89A-M216A, I43V-A29G-D58P-Y89A-M216F, I43V-A29G-D58P-Y89A-M216L,I43V-A29G-Y89A-M117A- M216A, I43V-A29G-Y89A-M117A-M216F, I43V-A29G-Y89A-M117A-M216L, I43V-A29G-Y89A- M117F-M216A, I43V-A29G-Y89A-M117F-M216F, I43V-A29G-Y89A-M117F-M216L, I43V-A29G- Y89A-M117I-M216A, I43V-A29G-Y89A-M117I-M216F, I43V-A29G-Y89A-M117I-M216L, I43V-A29G- Y89A-M117L-M216A, I43V-A29G-Y89A-M117L-M216F, I43V-A29G-Y89A-M117L-M216L, I43V- A29G-Y89A-M117V-M216A, I43V-A29G-Y89A-M117V-M216F, I43V-A29G-Y89A-M117V-M216L, I43V-D58P, I43V-D58P-Y89A, I43V-D58P-M117A, I43V-D58P-M117F, I43V-D58P-M1171, I43V-D58P- M117L, I43V-D58P-M117V, I43V-D58P-M216A, I43V-D58P-M216F, I43V-D58P-M216L, I43V-D58P- Y89A-M117A, I43V-D58P-Y89A-M117F, I43V-D58P-Y89A-M1171, I43V-D58P-Y89A-M117L, I43V- D58P-Y89A-M117V, I43V-D58P-Y89A-M216A, I43V-D58P-Y89A-M216F, I43V-D58P-Y89A-M216L, I43V-D58P-M117A-M216A, I43V-D58P-M117A-M216F, I43V-D58P-M117A-M216L, I43V-D58P- M117F-M216A, I43V-D58P-M117F-M216F, I43V-D58P-M117F-M216L, I43V-D58P-M117I-M216A, I43V-D58P-M117I-M216F, I43V-D58P-M117I-M216L, I43V-D58P-M117L-M216A,I43V-D58P-M117L- M216F, I43V-D58P-M117L-M216L, I43V-D58P-M117V-M216A, I43V-D58P-M117V-M216F, I43V- D58P-M117V-M216L, I43V-Y89A, I43V-Y89A-M117A, I43V-Y89A-M117F, I43V-Y89A-M1171, I43V- Y89A-M117L, I43V-Y89A-M117V, I43V-Y89A-M216A, I43V-Y89A-M216F, I43V-Y89A-M216L, I43V- Y89A-M117A-M216A, I43V-Y89A-M117A-M216F, I43V-Y89A-M117A-M216L, I43V-Y89A-M117F- M216A, I43V-Y89A-M117F-M216F, I43V-Y89A-M117F-M216L, I43V-Y89A-M117I-M216A, I43V- Y89A-M117I-M216F, I43V-Y89A-M117I-M216L, I43V-Y89A-M117L-M216A, I43V-Y89A-M117L- M216F, I43V-Y89A-M117L-M216L, I43V-Y89A-M117V-M216A, I43V-Y89A-M117V-M216F, I43V- Y89A-M117V-M216L, I43V-M117A, I43V-M117F, I43V-M1171, I43V-M117L, I43V-M117V, I43V- M117A-M216A, I43V-M117A-M216F, I43V-M117A-M216L, I43V-M117F-M216A, I43V-M117F-M216F, I43V-M117F-M216L, I43V-M117I-M216A, I43V-M117I-M216F, I43V-M117I-M216L, I43V-M117L- M216A, I43V-M117L-M216F, I43V-M117L-M216L, I43V-M117V-M216A, I43V-M117V-M216F, I43V- M117V-M216L, I43V-M216A, I43V-M216F, 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M122L-N154S-T156A- M117A,M122L-N154S-T156A-M117F, M122L-N154S-T156A-M1171, M122L-N154S-T156A-M117L, M122L-N154S-T156A-M117V, M122L-N154S-T156A-M117A-M216A, M122L-N154S-T156A-M117A- M216F, M122L-N154S-T156A-M117A-M216L, M122L-N154S-T156A-M117F-M216A, M122L-N154S- T156A-M117F-M216F, M122L-N154S-T156A-M117F-M216L, M122L-N154S-T156A-M117I-M216A, M122L-N154S-T156A-M117I-M216F, M122L-N154S-T156A-M117I-M216L, M122L-N154S-T156A- M117L-M216A, M122L-N154S-T156A-M117L-M216F, M122L-N154S-T156A-M117L-M216L, M122L- N154S-T156A-M117V-M216A, M122L-N154S-T156A-M117V-M216F, M122L-N154S-T156A-M117V- M216L, M122L-N154S-T156A-M216A, M122L-N154S-T156A-M216F, M122L-N154S-T156A-M216L, M211 N-P212D-A29G, M211 N-P212D-A29G-D58P, M211 N-P212D-A29G-Y89A, M211 N-P212D- A29G-M117A, M211 N-P212D-A29G-M117F, M211 N-P212D-A29G-M117I, M211 N-P212D-A29G- M117L, M211 N-P212D-A29G-M117V, M211 N-P212D-A29G-M216A, M211 N-P212D-A29G-M216F, M211 N-P212D-A29G-M216L, M211 N-P212D-A29G-D58P-Y89A, M211 N-P212D-A29G-D58P-M117A,M211 N-P212D-A29G-D58P-M117F, M211 N-P212D-A29G-D58P-M117I, M211 N-P212D-A29G-D58P- M117L, M211 N-P212D-A29G-D58P-M117V, M211 N-P212D-A29G-D58P-M216A, M211 N-P212D- A29G-D58P-M216F, M211 N-P212D-A29G-D58P-M216L, M211 N-P212D-A29G-Y89A-M117A, M211 N-P212D-A29G-Y89A-M117F, M211 N-P212D-A29G-Y89A-M1171, M211 N-P212D-A29G-Y89A- M117L, M211 N-P212D-A29G-Y89A-M117V, M211 N-P212D-A29G-Y89A-M216A, M211 N-P212D- A29G-Y89A-M216F, M211 N-P212D-A29G-Y89A-M216L, M211 N-P212D-A29G-M117A-M216A, M211 N-P212D-A29G-M117A-M216F, M211 N-P212D-A29G-M117A-M216L, M211 N-P212D-A29G- D58P-Y89A-M117A, M211 N-P212D-A29G-D58P-Y89A-M117F, M211 N-P212D-A29G-D58P-Y89A- M117I, M211 N-P212D-A29G-D58P-Y89A-M117L, M211 N-P212D-A29G-D58P-Y89A-M117V, M211 N- P212D-A29G-D58P-Y89A-M216A, M211 N-P212D-A29G-D58P-Y89A-M216F, M211 N-P212D-A29G- D58P-Y89A-M216L, M211 N-P212D-A29G-Y89A-M117A-M216A, M211 N-P212D-A29G-Y89A-M117A- M216F, M211 N-P212D-A29G-Y89A-M117A-M216L, M211 N-P212D-A29G-Y89A-M117F-M216A,M211 N-P212D-A29G-Y89A-M117F-M216F, M211 N-P212D-A29G-Y89A-M117F-M216L, M211 N- P212D-A29G-Y89A-M117I-M216A, M211 N-P212D-A29— Y89A-M117I-M216F, M211 N-P212D-A29G- Y89A-M117I-M216L, M211 N-P212D-A29G-Y89A-M117L-M216A, M211 N-P212D-A29G-Y89A-M117L- M216F, M211 N-P212D-A29G-Y89A-M117L-M216L, M211 N-P212D-A29G-Y89A-M117V-M216A, M211 N-P212D-A29G-Y89A-M117V-M216F, M211 N-P212D-A29— Y89A-M117V-M216L, M211 N- P212D-D58P, M211 N-P212D-D58P-Y89A, M211 N-P212D-D58P-M117A, M211 N-P212D-D58P- M117F, M211 N-P212D-D58P-M117I, M211 N-P212D-D58P-M117L, M211 N-P212D-D58P-M117V, M211 N-P212D-D58P-M216A, M211 N-P212D-D58P-M216F, M211 N-P212D-D58P-M216L, M211 N- P212D-D58P-Y89A-M117A, M211 N-P212D-D58P-Y89A-M117F, M211 N-P212D-D58P-Y89A-M117I, M211 N-P212D-D58P-Y89A-M117L, M211 N-P212D-D58P-Y89A-M117V, M211 N-P212D-D58P-Y89A- M216A, M211 N-P212D-D58P-Y89A-M216F, M211 N-P212D-D58P-Y89A-M216L, M211 N-P212D- D58P-M117A-M216A, M211 N-P212D-D58P-M117A-M216F, M211 N-P212D-D58P-M117A-M216L,M211 N-P212D-D58P-M117F-M216A, M211 N-P212D-D58P-M117F-M216F, M211 N-P212D-D58P- M117F-M216L, M211 N-P212D-D58P-M117I-M216A, M211 N-P212D-D58P-M117I-M216F, M211 N- P212D-D58P-M117I-M216L, M211 N-P212D-D58P-M117L-M216A, M211 N-P212D-D58P-M117L- M216F, M211 N-P212D-D58P-M117L-M216L, M211 N-P212D-D58P-M117V-M216A, M211 N-P212D- D58P-M117V-M216F, M211 N-P212D-D58P-M117V-M216L, M211 N-P212D-Y89A, M211 N-P212D- Y89A-M117A, M211 N-P212D-Y89A-M117F, M211 N-P212D-Y89A-M1171, M211 N-P212D-Y89A- M117L, M211 N-P212D-Y89A-M117V, M211 N-P212D-Y89A-M216A, M211 N-P212D-Y89A-M216F, M211 N-P212D-Y89A-M216L, M211 N-P212D-Y89A-M117A-M216A, M211 N-P212D-Y89A-M117A- M216F, M211 N-P212D-Y89A-M117A-M216L, M211 N-P212D-Y89A-M117F-M216A, M211 N-P212D- Y89A-M117F-M216F, M211 N-P212D-Y89A-M117F-M216L, M211 N-P212D-Y89A-M117I-M216A, M211 N-P212D-Y89A-M117I-M216F, M211 N-P212D-Y89A-M117I-M216L, M211 N-P212D-Y89A- M117L-M216A, M211 N-P212D-Y89A-M117L-M216F, M211 N-P212D-Y89A-M117L-M216L,M211 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L-P212D-D58P-Y89A-M117A, D127P- M211 L-P212D-D58P-Y89A-M117F, D127P-M211 L-P212D-D58P-Y89A-M117I, D127P-M211 L- P212D-D58P-Y89A-M117L, D127P-M211 L-P212D-D58P-Y89A-M117V, D127P-M211 L-P212D-D58P- Y89A-M216A, D127P-M211 L-P212D-D58P-Y89A-M216F, D127P-M211 L-P212D-D58P-Y89A-M216L, D127P-M211 L-P212D-D58P-M117A-M216A, D127P-M211 L-P212D-D58P-M117A-M216F, D127P- M211 L-P212D-D58P-M117A-M216L, D127P-M211 L-P212D-D58P-M117F-M216A, D127P-M211 L- P212D-D58P-M117F-M216F, D127P-M211 L-P212D-D58P-M117F-M216L, D127P-M211 L-P212D- D58P-M117I-M216A, D127P-M211 L-P212D-D58P-M117I-M216F, D127P-M211 L-P212D-D58P- M117I-M216L, D127P-M211 L-P212D-D58P-M117L-M216A, D127P-M211 L-P212D-D58P-M117L- M216F, D127P-M211 L-P212D-D58P-M117L-M216L, D127P-M211 L-P212D-D58P-M117V-M216A, D127P-M211 L-P212D-D58P-M117V-M216F, D127P-M211 L-P212D-D58P-M117V-M216L, D127P- M211 L-P212D-Y89A, D127P-M211 L-P212D-Y89A-M117A, D127P-M211 L-P212D-Y89A-M117F, D127P-M211 L-P212D-Y89A-M1171,D127P-M211 L-P212D-Y89A-M117L, D127P-M211 L-P212D- Y89A-M117V, D127P-M211 L-P212D-Y89A-M216A, D127P-M211 L-P212D-Y89A-M216F, D127P- M211 L-P212D-Y89A-M216L, D127P-M211 L-P212D-Y89A-M117A-M216A, D127P-M211 L-P212D- Y89A-M117A-M216F, D127P-M211 L-P212D-Y89A-M117A-M216L, D127P-M211 L-P212D-Y89A- M117F-M216A, D127P-M211 L-P212D-Y89A-M117F-M216F, D127P-M211 L-P212D-Y89A-M117F- M216L, D127P-M211 L-P212D-Y89A-M117I-M216A, D127P-M211 L-P212D-Y89A-M117I-M216F, D127P-M211 L-P212D-Y89A-M117I-M216L, D127P-M211 L-P212D-Y89A-M117L-M216A, D127P- M211 L-P212D-Y89A-M117L-M216F, D127P-M211 L-P212D-Y89A-M117L-M216L, D127P-M211 L- P212D-Y89A-M117V-M216A, D127P-M211 L-P212D-Y89A-M117V-M216F, D127P-M211 L-P212D- Y89A-M117V-M216L, D127P-M211 L-P212D-M117A, D127P-M211 L-P212D-M117F, D127P-M211 L- P212D-M117I, D127P-M211 L-P212D-M117L, D127P-M211 L-P212D-M117V, D127P-M211L-P212D- M117A-M216A, D127P-M211 L-P212D-M117A-M216F, D127P-M211 L-P212D-M117A-M216L, D127P- M211 L-P212D-M117F-M216A,D127P-M211 L-P212D-M117F-M216F, D127P-M211 L-P212D-M117F- M216L, D127P-M211 L-P212D-M117I-M216A, D127P-M211 L-P212D-M117I-M216F, D127P-M211 L- P212D-M117I-M216L, D127P-M211 L-P212D-M117L-M216A, D127P-M211 L-P212D-M117L-M216F, D127P-M211 L-P212D-M117L-M216L, D127P-M211 L-P212D-M117V-M216A, D127P-M211 L-P212D- M117V-M216F, D127P-M211 L-P212D-M117V-M216L, D127P-M211 L-P212D-M216A, D127P-M211 L- P212D-M216F, D127P-M211 L-P212D-M216L, P212H-A29G, P212H-A29G-D58P, P212H-A29G- Y89A, P212H-A29G-M117A, P212H-A29G-M117F, P212H-A29G-M1171, P212H-A29G-M117L, P212H-A29G-M117V, P212H-A29G-M216A, P212H-A29G-M216F, P212H-A29G-M216L, P212H- A29G-D58P-Y89A, P212H-A29G-D58P-M117A, P212H-A29G-D58P-M117F, P212H-A29G-D58P- M117I, P212H-A29G-D58P-M117L, P212H-A29G-D58P-M117V, P212H-A29G-D58P-M216A, P212H- A29G-D58P-M216F, P212H-A29G-D58P-M216L, P212H-A29G-Y89A-M117A, P212H-A29G-Y89A- M117F, P212H-A29G-Y89A-M1171, P212H-A29G-Y89A-M117L, P212H-A29G-Y89A-M117V, P212H- A29G-Y89A-M216A, P212H-A29G-Y89A-M216F,P212H-A29G-Y89A-M216L, P212H-A29G-M117A- M216A, P212H-A29G-M117A-M216F, P212H-A29G-M117A-M216L, P212H-A29G-D58P-Y89A- M117A, P212H-A29G-D58P-Y89A-M117F, P212H-A29G-D58P-Y89A-M117I, P212H-A29G-D58P- Y89A-M117L, P212H-A29G-D58P-Y89A-M117V, P212H-A29G-D58P-Y89A-M216A, P212H-A29G- D58P-Y89A-M216F, P212H-A29G-D58P-Y89A-M216L, P212H-A29G-Y89A-M117A-M216A, P212H- A29G-Y89A-M117A-M216F, P212H-A29G-Y89A-M117A-M216L, P212H-A29G-Y89A-M117F-M216A, P212H-A29G-Y89A-M117F-M216F, P212H-A29G-Y89A-M117F-M216L, P212H-A29G-Y89A-M1171- M216A, P212H-A29G-Y89A-M117I-M216F, P212H-A29G-Y89A-M117I-M216L, P212H-A29G-Y89A- M117L-M216A, P212H-A29G-Y89A-M117L-M216F, P212H-A29G-Y89A-M117L-M216L, P212H- A29G-Y89A-M117V-M216A, P212H-A29G-Y89A-M117V-M216F, P212H-A29G-Y89A-M117V-M216L, P212H-D58P, P212H-D58P-Y89A, P212H-D58P-M117A, P212H-D58P-M117F, P212H-D58P-M1171, P212H-D58P-M117L, P212H-D58P-M117V, P212H-D58P-M216A, P212H-D58P-M216F, P212H- D58P-M216L, P212H-D58P-Y89A-M117A, P212H-D58P-Y89A-M117F,P212H-D58P-Y89A-M117I, P212H-D58P-Y89A-M117L, P212H-D58P-Y89A-M117V, P212H-D58P-Y89A-M216A, P212H-D58P- Y89A-M216F, P212H-D58P-Y89A-M216L, P212H-D58P-M117A-M216A, P212H-D58P-M117A- M216F, P212H-D58P-M117A-M216L, P212H-D58P-M117F-M216A, P212H-D58P-M117F-M216F, P212H-D58P-M117F-M216L, P212H-D58P-M117I-M216A, P212H-D58P-M117I-M216F, P212H- D58P-M117I-M216L, P212H-D58P-M117L-M216A, P212H-D58P-M117L-M216F, P212H-D58P- M117L-M216L, P212H-D58P-M117V-M216A, P212H-D58P-M117V-M216F, P212H-D58P-M117V- M216L, P212H-Y89A, P212H-Y89A-M117A, P212H-Y89A-M117F, P212H-Y89A-M1171, P212H- Y89A-M117L, P212H-Y89A-M117V, P212H-Y89A-M216A, P212H-Y89A-M216F, P212H-Y89A- M216L, P212H-Y89A-M117A-M216A, P212H-Y89A-M117A-M216F, P212H-Y89A-M117A-M216L, P212H-Y89A-M117F-M216A, P212H-Y89A-M117F-M216F, P212H-Y89A-M117F-M216L, P212H- Y89A-M117I-M216A, P212H-Y89A-M117I-M216F, P212H-Y89A-M117I-M216L, P212H-Y89A-M117L- M216A, P212H-Y89A-M117L-M216F, P212H-Y89A-M117L-M216L, P212H-Y89A-M117V-M216A, P212H-Y89A-M117V-M216F,P212H-Y89A-M117V-M216L, P212H-M117A, P212H-M117F, P212H- M117I, P212H-M117L, P212H-M117V, P212H-M117A-M216A, P212H-M117A-M216F, P212H- M117A-M216L, P212H-M117F-M216A, P212H-M117F-M216F, P212H-M117F-M216L, P212H-M117I- M216A, P212H-M117I-M216F, P212H-M117I-M216L, P212H-M117L-M216A, P212H-M117L-M216F, P212H-M117L-M216L, P212H-M117V-M216A, P212H-M117V-M216F, P212H-M117V-M216L, P212H-M216A, P212H-M216F, P212H-M216L, Q12L-M122L-A222S-A29G, Q12L-M122L-A222S- A29G-D58P, Q12L-M122L-A222S-A29G-Y89A, Q12L-M122L-A222S-A29G-M117A, Q12L-M122L- A222S-A29G-M117F, Q12L-M122L-A222S-A29G-M1171, Q12L-M122L-A222S-A29G-M117L, Q12L- M122L-A222S-A29G-M117V, Q12L-M122L-A222S-A29G-M216A, Q12L-M122L-A222S-A29G-M216F, Q12L-M122L-A222S-A29G-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A, Q12L-M122L-A222S- A29G-D58P-M117A, Q12L-M122L-A222S-A29G-D58P-M117F, Q12L-M122L-A222S-A29G-D58P- M117I, Q12L-M122L-A222S-A29G-D58P-M117L, Q12L-M122L-A222S-A29G-D58P-M117V, Q12L- M122L-A222S-A29G-D58P-M216A,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-D58P-M216F, Q12L-M122L-A222S-A29G-D58P-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A, Q12L-M122L-A222S-A29G-Y89A-M117F, Q12L-M122L-A222S-A29G-Y89A-M117I, Q12L-M122L-A222S-A29G-Y89A-M117L, Q12L-M122L-A222S-A29G-Y89A-M117V, Q12L-M122L-A222S-A29G-Y89A-M216A, Q12L-M122L-A222S-A29G-Y89A-M216F, Q12L-M122L-A222S-A29G-Y89A-M216L, Q12L-M122L-A222S-A29G-M117A-M216A, Q12L-M122L-A222S-A29G-M117A-M216F, Q12L-M122L-A222S-A29G-M117A-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117A, Q12L-M122L-A222S-A29G-D58P-Y89A-M117F, Q12L-M122L-A222S-A29G-D58P-Y89A-M117I, Q12L-M122L-A222S-A29G-D58P-Y89A-M117L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117V, Q12L-M122L-A222S-A29G-D58P-Y89A-M216A, Q12L-M122L-A222S-A29G-D58P-Y89A-M216F, Q12L-M122L-A222S-A29G-D58P-Y89A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A-M216A, Q12L-M122L-A222S-A29G-Y89A-M117A-M216F, Q12L-M122L-A222S-A29G-Y89A-M117A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117F-M216A, Q12L-M122L-A222S-A29G-Y89A-M117F-M216F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117F-M216L, Q12L-M122L-A222S-A29G-Y89A-M117I-M216A, Q12L-M122L-A222S-A29G-Y89A-M117I-M216F, Q12L-M122L-A222S-A29G-Y89A-M117I-M216L, Q12L-M122L-A222S-A29G-Y89A-M117L-M216A, Q12L-M122L-A222S-A29G-Y89A-M117L-M216F, Q12L-M122L-A222S-A29G-Y89A-M117L-M216L, Q12L-M122L-A222S-A29G-Y89A-M117V-M216A, Q12L-M122L-A222S-A29G-Y89A-M117V-M216F, Q12L-M122L-A222S-A29G-Y89A-M117V-M216L, Q12L-M122L-A222S-D58P, Q12L-M122L-A222S-D58P-Y89A, Q12L-M122L-A222S-D58P-M117A, Q12L-M122L-A222S-D58P-M117F, Q12L-M122L- A222S-D58P-M1171, Q12L-M122L-A222S-D58P-M117L, Q12L-M122L-A222S-D58P-M117V, Q12L- M122L-A222S-D58P-M216A, Q12L-M122L-A222S-D58P-M216F, Q12L-M122L-A222S-D58P-M216L, Q12L-M122L-A222S-D58P-Y89A-M117A, Q12L-M122L-A222S-D58P-Y89A-M117F, Q12L-M122L-A222S-D58P-Y89A-M1171, Q12L-M122L-A222S-D58P-Y89A-M117L, Q12L-M122L-A222S-D58P-Y89A-M117V, Q12L-M122L-A222S-D58P-Y89A-M216A, Q12L-M122L-A222S-D58P-Y89A-M216F, Q12L-M122L-A222S-D58P-Y89A-M216L, Q12L-M122L-A222S-D58P-M117A-M216A,<h2 style=";text-align:left;direction:ltr">Q12L-M122L- A222S-D58P-M117A-M216F, Q12L-M122L-A222S-D58P-M117A-M216L, Q12L-M122L-A222S-D58P- M117F-M216A, Q12L-M122L-A222S-D58P-M117F-M216F, Q12L-M122L-A222S-D58P-M117F- M216L, Q12L-M122L-A222S-D58P-M117I-M216A, Q12L-M122L-A222S-D58P-M117I-M216F, Q12L- M122L-A222S-D58P-M117I-M216L, Q12L-M122L-A222S-D58P-M117L-M216A, Q12L-M122L-A222S- D58P-M117L-M216F, Q12L-M122L-A222S-D58P-M117L-M216L, Q12L-M122L-A222S-D58P-M117V- M216A, Q12L-M122L-A222S-D58P-M117V-M216F, Q12L-M122L-A222S-D58P-M117V-M216L, Q12L-M122L-A222S-Y89A, Q12L-M122L-A222S-Y89A-M117A, Q12L-M122L-A222S-Y89A-M117F, Q12L-M122L-A222S-Y89A-M1171, Q12L-M122L-A222S-Y89A-M117L, Q12L-M122L-A222S-Y89A-M117V, Q12L-M122L-A222S-Y89A-M216A, Q12L-M122L-A222S-Y89A-M216F, Q12L-M122L-A222S-Y89A-M216L, Q12L-M122L-A222S-Y89A-M117A-M216A, Q12L-M122L-A222S-Y89A-M117A-M216F, Q12L-M122L-A222S-Y89A-M117A-M216L, Q12L-M122L-A222S-Y89A-M117F-M216A, Q12L-M122L-A222S-Y89A-M117F-M216F, Q12L-M122L-A222S-Y89A-M117F-M216L, Q12L-M122L-A222S-Y89A-M117I-M216A,Q12L-M122L-A222S-Y89A-M117I-M216F, Q12L-M122L-A222S-Y89A-M117I-M216L, Q12L-M122L-A222S-Y89A-M117L-M216A, Q12L-M122L-A222S-Y89A-M117L-M216F, Q12L-M122L- A222S-Y89A-M117L-M216L, Q12L-M122L-A222S-Y89A-M117V-M216A, Q12L-M122L-A222S-Y89A-M117V-M216F, Q12L-M122L-A222S-Y89A-M117V-M216L, Q12L-M122L-A222S-M117A, Q12L-M122L-A222S-M117F, Q12L-M122L-A222S-M1171, Q12L-M122L-A222S-M117L, Q12L-M122L- A222S-M117V, Q12L-M122L-A222S-M117A-M216A, Q12L-M122L-A222S-M117A-M216F, Q12L- M122L-A222S-M117A-M216L, Q12L-M122L-A222S-M117F-M216A, Q12L-M122L-A222S-M117F-M216F, Q12L-M122L-A222S-M117F-M216L, Q12L-M122L-A222S-M117I-M216A, Q12L-M122L-A222S-M117I-M216F, Q12L-M122L-A222S-M117I-M216L, Q12L-M122L-A222S-M117L-M216A, Q12L-M122L-A222S-M117L-M216F, Q12L-M122L-A222S-M117L-M216L, Q12L-M122L-A222S- M117V-M216A, Q12L-M122L-A222S-M117V-M216F, Q12L-M122L-A222S-M117V-M216L, Q12L- M122L-A222S-M216A, Q12L-M122L-A222S-M216F, Q12L-M122L-A222S-M216L existing group is selected,wherein the numbering is based on the numbering according to SEQ ID NO:1 and wherein the protease does not comprise any further changes besides the amino acid substitutions mentioned.

[0064] In preferred embodiments, the protease according to the invention comprises an amino acid substitution combination selected from the group consisting of M211 L-P212D-A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L-P212D-A29G-M117V, M211 L- P212D-A29G-M216A, M211 L-P212D-A29G-M216F, M211 L-P212D-A29G-M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P-M117A, M211 L-P212D-A29G-D58P-M117F, M211 L-P212D-A29G-D58P-M1171, M211 L-P212D-A29G-D58P-M117L, M211 L-P212D-A29G-D58P-M117V, M211 L-P212D-A29G-D58P-M216A, M211 L-P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P- M216L, M211 L-P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D- A29G-Y89A-M1171, M211 L-P212D-A29G-Y89A-M117L, M211 L-P212D-A29G-Y89A-M117V, M211 L- P212D-A29G-Y89A-M216A, M211 L-P212D-A29G-Y89A-M216F, M211 L-P212D-A29G-Y89A-M216L, M211 L-P212D-A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F,M211 L-P212D-A29G- M117A-M216L, M211 L-P212D-A29G-D58P-Y89A-M117A, M211 L-P212D-A29G-D58P-Y89A-M117F, M211 L-P212D-A29G-D58P-Y89A-M117I , M211 L-P212D-A29G-D58P-Y89A-M117L, M211 L-P212D- A29G-D58P-Y89A-M117V, M211 L-P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P- Y89A-M216F, M211 L-P212D-A29G-D58P-Y89A-M216L, M211 L-P212D-A29G-Y89A-M117A-M216A, M211 L-P212D-A29G-Y89A-M117A-M216F, M211 L-P212D-A29G-Y89A-M117A-M216L, M211 L- P212D-A29G-Y89A-M117F-M216A, M211 L-P212D-A29G-Y89A-M117F-M216F, M211 L-P212D- A29G-Y89A-M117F-M216L, M211 L-P212D-A29G-Y89A-M117I-M216A, M211 L-P212D-A29G-Y89A- M117I-M216F, M211 L-P212D-A29G-Y89A-M117I-M216L, M211 L-P212D-A29G-Y89A-M117L-M216A, M211 L-P212D-A29G-Y89A-M117L-M216F, M211 L-P212D-A29G-Y89A-M117L-M216L, M211 L- P212D-A29G-Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V-M216F, M211 L-P212D- A29G-Y89A-M117V-M216L, M211 L-P212D-D58P, M211 L-P212D-D58P-Y89A, M211 L-P212D-D58P- M117A, M211 L-P212D-D58P-M117F, M211 L-P212D-D58P-M117I,M211 L-P212D-D58P-M117L, M211 L-P212D-D58P-M117V, M211 L-P212D-D58P-M216A, M211 L-P212D-D58P-M216F, M211 L- P212D-D58P-M216L, M211 L-P212D-D58P-Y89A-M117A, M211 L-P212D-D58P-Y89A-M117F, M211 L-P212D-D58P-Y89A-M117I, M211 L-P212D-D58P-Y89A-M117L, M211 L-P212D-D58P-Y89A- M117V, M211 L-P212D-D58P-Y89A-M216A, M211 L-P212D-D58P-Y89A-M216F, M211 L-P212D- D58P-Y89A-M216L, M211 L-P212D-D58P-M117A-M216A, M211 L-P212D-D58P-M117A-M216F, M211 L-P212D-D58P-M117A-M216L, M211 L-P212D-D58P-M117F-M216A, M211 L-P212D-D58P- M117F-M216F, M211 L-P212D-D58P-M117F-M216L, M211 L-P212D-D58P-M117I-M216A, M211 L- P212D-D58P-M117I-M216F, M211 L-P212D-D58P-M117I-M216L, M211 L-P212D-D58P-M117L- M216A, M211 L-P212D-D58P-M117L-M216F, M211 L-P212D-D58P-M117L-M216L, M211 L-P212D- D58P-M117V-M216A, M211 L-P212D-D58P-M117V-M216F, M211 L-P212D-D58P-M117V-M216L, M211 L-P212D-Y89A, M211 L-P212D-Y89A-M117A, M211 L-P212D-Y89A-M117F, M211 L-P212D- Y89A-M117I, M211 L-P212D-Y89A-M117L, M211 L-P212D-Y89A-M117V,M211 L-P212D-Y89A- M216A, M211 L-P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L, M211 L-P212D-Y89A-M117A- M216A, M211 L-P212D-Y89A-M117A-M216F, M211 L-P212D-Y89A-M117A-M216L, M211L-P212D- Y89A-M117F-M216A, M211 L-P212D-Y89A-M117F-M216F, M211 L-P212D-Y89A-M117F-M216L, M211 L-P212D-Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A- M117I-M216L, M211 L-P212D-Y89A-M117L-M216A, M211 L-P212D-Y89A-M117L-M216F, M211 L- P212D-Y89A-M117L-M216L, M211 L-P212D-Y89A-M117V-M216A, M211 L-P212D-Y89A-M117V- M216F, M211 L-P212D-Y89A-M117V-M216L, M211 L-P212D-M117A, M211 L-P212D-M117F, M211 L- P212D-M117I, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L- P212D-M117A-M216F, M211 L-P212D-M117A-M216L, M211 L-P212D-M117F-M216A, M211 L-P212D- M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211L-P212D-M1171- M216F, M211 L-P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L-P212D-M117L-M216F, M211 L-P212D-M117L-M216L, M211 L-P212D-M117V-M216A,M211 L-P212D-M117V-M216F, M211 L-P212D-M117V-M216L, M211 L-P212D-M216A, M211 L-P212D-M216F, M211 L-P212D-M216L, wherein the numbering is based in each case on the numbering according to SEQ ID NO:1 and wherein the protease comprises no further changes besides the amino acid substitutions mentioned.

[0065] In preferred embodiments, the protease according to the invention comprises an amino acid substitution combination selected from the group consisting of M117A-M211 L-P212D, Y89A-M117A-M211 L-P212D, M117V-M211 L-P212D, A29G-M117V-M211 L-P212D, M117F-M211 L-P212D, M117I-M211 L-P212D, M117L-M211 L-P212D, M211 L-P212D-M216F, D58P-M211 L-P212D-M216A and M211 L-P212D-M216L, wherein the numbering is in each case based on the numbering according to SEQ ID NO:1 and wherein the Protease does not contain any further changes besides the amino acid substitutions mentioned.In preferred embodiments, the combinations of the amino acid substitutions according to the invention from groups (i) and (ii) described herein lead to improved cleaning performance of this modified protease in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing detergents, particularly preferably bleach-containing automatic dishwashing detergents, on at least one protease-sensitive soil. Proteases according to the invention therefore enable improved removal of at least one, preferably several, protease-sensitive soils on textiles and / or hard surfaces, in particular tableware. Typical protease-sensitive soils include, for example, egg (yolk), blood, milk, and other protein-containing soils.An improvement in cleaning performance according to the invention, in particular in proteolytic cleaning performance, is present when the protease shows improved cleaning performance compared to a reference protease on at least one protease-sensitive soil, which is preferably selected from the group consisting of blood, egg (yolk), milk and other protein-containing soils.

[0066] In preferred embodiments, the combinations of the amino acid substitutions from groups (i) and (ii) described herein lead to improved stability of this modified protease in detergents or cleaning agents, in particular bleach-containing detergents and cleaning agents, preferably automatic dishwashing detergents, particularly preferably bleach-containing automatic dishwashing detergents. In preferred embodiments, the combinations of the amino acid substitutions from groups (i) and (ii) described herein lead to improved stability of this modified protease in the presence of bleaching agents, in particular oxidizing agents.

[0067] Proteases according to the invention can therefore be used in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents, particularly preferably bleach-containing automatic dishwashing agents. Proteases according to the invention can therefore be used in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents, particularly preferably bleach-containing automatic dishwashing agents, and exhibit a cleaning performance in such agents. In particular, proteases according to the invention can improve the cleaning performance of bleach- and enzyme-containing, in particular protease-containing, washing and cleaning agents, in particular automatic dishwashing agents, particularly with regard to protease-sensitive soils.

[0068] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents, particularly preferably bleach-containing automatic dishwashing agents, wherein the stability is determined as described in Example 3.

[0069] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents, particularly preferably bleach-containing automatic dishwashing agents, wherein the stability is determined as described in Example 3.

[0070] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 211 and 212, at least one amino acid substitution selected from the group consisting of M211 N, M211 L, P212D and P212H, preferably M211 L and / or P212D, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution,which is selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents, particularly preferably bleach-containing automatic dishwashing agents, wherein the stability is determined as described in Example 3.

[0071] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, two amino acid substitutions selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L, wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents, particularly preferably bleach-containing automatic dishwashing agents, the stability being determined as described in Example 3.

[0072] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, the amino acid substitutions M211L and P212D, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L,wherein the protease has improved stability in washing or cleaning agents, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing agents, particularly preferably automatic dishwashing agents containing bleach, the stability being determined as described in Example 3.

[0073] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, (i) an amino acid substitution or amino acid substitution combination selected from the group consisting of 143V, M122L-N154S-T156A, M211 N-P212D, M211 L-P212D, G160S, D127P-M211 L-P212D, P212H and Q12L-M122L-A222S, and (ii) an amino acid substitution or amino acid substitution combination selected from the group consisting of A29G, A29G-D58P, A29G-Y89A, A29G-M117A, A29G-M117F, A29G-M1171, A29G-M117L, A29G-M117V,<h2 style=";text-align:left;direction:ltr">A29G-M216A, A29G-M216F, A29G-M216L, A29G-D58P-Y89A, A29G-D58P- M117A, A29G-D58P-M117F, A29G-D58P-M1171, A29G-D58P-M117L, A29G-D58P-M117V, A29G- D58P-M216A, A29G-D58P-M216F, A29G-D58P-M216L, A29G-Y89A-M117A, A29G-Y89A-M117F, A29G-Y89A-M1171, A29G-Y89A-M117L, A29G-Y89A-M117V, A29G-Y89A-M216A, A29G-Y89A-M216F, A29G-Y89A-M216L, A29G-M117A-M216A, A29G-M117A-M216F, A29G-M117A-M216L, A29G-D58P-Y89A-M117A, A29G-D58P-Y89A-M117F, A29G-D58P-Y89A-M1171, A29G-D58P-Y89A-M117L, A29G-D58P-Y89A-M117V, A29G-D58P-Y89A-M216A, A29G-D58P-Y89A-M216F, A29G- D58P-Y89A-M216L, A29G-Y89A-M117A-M216A, A29G-Y89A-M117A-M216F, A29G-Y89A-M117A-M216L, A29G-Y89A-M117F-M216A, A29G-Y89A-M117F-M216F, A29G-Y89A-M117F-M216L, A29G-Y89A-M117I-M216A, A29G-Y89A-M117I-M216F, A29G-Y89A-M117I-M216L, A29G-Y89A-M117L- M216A, A29G-Y89A-M117L-M216F, A29G-Y89A-M117L-M216L, A29G-Y89A-M117V-M216A, A29G-Y89A-M117V-M216F, A29G-Y89A-M117V-M216L, D58P, D58P-Y89A, D58P-M117A, D58P-M117F, D58P-M117I, D58P-M117L, D58P-M117V, D58P-M216A,D58P-M216F, D58P-M216L, D58P-Y89A- M117A, D58P-Y89A-M117F, D58P-Y89A-M1171, D58P-Y89A-M117L, D58P-Y89A-M117V, D58P- Y89A-M216A, D58P-Y89A-M216F, D58P-Y89A-M216L, D58P-M117A-M216A, D58P-M117A-M216F, D58P-M117A-M216L, D58P-M117F-M216A, D58P-M117F-M216F, D58P-M117F-M216L, D58P- M117I-M216A, D58P-M117I-M216F, D58P-M117I-M216L, D58P-M117L-M216A, D58P-M117L- M216F, D58P-M117L-M216L, D58P-M117V-M216A, D58P-M117V-M216F, D58P-M117V-M216L, Y89A, Y89A-M117A, Y89A-M117F, Y89A-M1171, Y89A-M117L, Y89A-M117V, Y89A-M216A, Y89A- M216F, Y89A-M216L, Y89A-M117A-M216A, Y89A-M117A-M216F, Y89A-M117A-M216L, Y89A- M117F-M216A, Y89A-M117F-M216F, Y89A-M117F-M216L, Y89A-M117I-M216A, Y89A-M117I- M216F, Y89A-M117I-M216L, Y89A-M117L-M216A, Y89A-M117L-M216F, Y89A-M117L-M216L, Y89A-M117V-M216A, Y89A-M117V-M216F, Y89A-M117V-M216L, M117A, M117F, M117I, M117L, M117V, M117A-M216A, M117A-M216F, M117A-M216L, M117F-M216A, M117F-M216F, M117F- M216L, M117I-M216A, M117I-M216F, M117I-M216L, M117L-M216A, M117L-M216F, M117L-M216L,M117V-M216A, M117V-M216F, M117V-M216L, M216A, M216F, M216L, wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing detergents, particularly preferably bleach-containing automatic dishwashing detergents, wherein the stability is determined as described in Example 3.

[0074] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, (i) an amino acid substitution or

[0075] Amino acid substitution combination selected from the group consisting of I43V, M122L-N154S-T156A, M211 N-P212D, M211 L-P212D, G160S, D127P-M211 L-P212D, P212H and Q12L-M122L-A222S, and (ii) an amino acid substitution or amino acid substitution combination selected from the group consisting of M117A, M117A-Y89L, M117V, M117V-A29G, M117F, M117I, M117L, M216F, D58P-M216A, M216L, wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably Dishwashing detergents, particularly preferably dishwashing detergents containing bleach, the stability being determined as described in Example 3.

[0076] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which is selected from the group consisting of I43V-A29G, I43V-A29G-D58P, I43V-A29G-Y89A, I43V-A29G-M117A, I43V-A29G-M117F, I43V-A29G-M117I, I43V-A29G-M117L, I43V-A29G-M117V, I43V-A29G-M216A, I43V-A29G-M216F, I43V-A29G-M216L, I43V-A29G-D58P-Y89A, I43V-A29G-D58P-M117A, I43V-A29G-D58P-M117F, I43V-A29G-D58P-M117I, I43V-A29G-D58P-M117L, I43V-A29G-D58P-M117V, I43V-A29G-D58P-M216A, I43V-A29G-D58P-M216F,I43V-A29G-D58P-M216L, I43V-A29G-Y89A-M117A, I43V-A29G- Y89A-M117F, I43V-A29G-Y89A-M1171, I43V-A29G-Y89A-M117L, I43V-A29G-Y89A-M117V, I43V- A29G-Y89A-M216A, I43V-A29G-Y89A-M216F, I43V-A29G-Y89A-M216L, I43V-A29G-M117A-M216A, I43V-A29G-M117A-M216F, I43V-A29G-M117A-M216L, I43V-A29G-D58P-Y89A-M117A, I43V-A29G- D58P-Y89A-M117F, I43V-A29G-D58P-Y89A-M1171, I43V-A29G-D58P-Y89A-M117L, I43V-A29G- D58P-Y89A-M117V, I43V-A29G-D58P-Y89A-M216A, I43V-A29G-D58P-Y89A-M216F, I43V-A29G- D58P-Y89A-M216L, I43V-A29G-Y89A-M117A-M216A, I43V-A29G-Y89A-M117A-M216F, I43V-A29G- Y89A-M117A-M216L, I43V-A29G-Y89A-M117F-M216A, I43V-A29G-Y89A-M117F-M216F, I43V- A29G-Y89A-M117F-M216L, I43V-A29G-Y89A-M117I-M216A, I43V-A29G-Y89A-M117I-M216F, I43V- A29G-Y89A-M117I-M216L, I43V-A29G-Y89A-M117L-M216A, I43V-A29G-Y89A-M117L-M216F, I43V- A29G-Y89A-M117L-M216L, I43V-A29G-Y89A-M117V-M216A, I43V-A29G-Y89A-M117V-M216F, I43V-A29G-Y89A-M117V-M216L, I43V-D58P, I43V-D58P-Y89A, I43V-D58P-M117A, I43V-D58P- M117F, I43V-D58P-M1171,I43V-D58P-M117L, I43V-D58P-M117V, I43V-D58P-M216A, I43V-D58P- M216F, I43V-D58P-M216L, I43V-D58P-Y89A-M117A, I43V-D58P-Y89A-M117F, I43V-D58P-Y89A- M117I, I43V-D58P-Y89A-M117L, I43V-D58P-Y89A-M117V, I43V-D58P-Y89A-M216A, I43V-D58P- Y89A-M216F, I43V-D58P-Y89A-M216L, I43V-D58P-M117A-M216A, I43V-D58P-M117A-M216F, I43V- D58P-M117A-M216L, I43V-D58P-M117F-M216A, I43V-D58P-M117F-M216F, I43V-D58P-M117F- M216L, I43V-D58P-M117I-M216A, I43V-D58P-M117I-M216F, I43V-D58P-M117I-M216L, I43V-D58P- M117L-M216A, I43V-D58P-M117L-M216F, I43V-D58P-M117L-M216L, I43V-D58P-M117V-M216A, I43V-D58P-M117V-M216F, I43V-D58P-M117V-M216L, I43V-Y89A, I43V-Y89A-M117A, I43V-Y89A- M117F, I43V-Y89A-M117I, I43V-Y89A-M117L, I43V-Y89A-M117V, I43V-Y89A-M216A, I43V-Y89A- M216F, I43V-Y89A-M216L, I43V-Y89A-M117A-M216A, I43V-Y89A-M117A-M216F, I43V-Y89A- M117A-M216L, I43V-Y89A-M117F-M216A, I43V-Y89A-M117F-M216F, I43V-Y89A-M117F-M216L, I43V-Y89A-M117I-M216A, I43V-Y89A-M117I-M216F, I43V-Y89A-M117I-M216L, I43V-Y89A-M117L- M216A,I43V-Y89A-M117L-M216F, I43V-Y89A-M117L-M216L, I43V-Y89A-M117V-M216A, I43V- Y89A-M117V-M216F, I43V-Y89A-M117V-M216L, I43V-M117A, I43V-M117F, I43V-M1171, I43V- M117L, I43V-M117V, I43V-M117A-M216A, I43V-M117A-M216F, I43V-M117A-M216L, I43V-M117F- M216A, I43V-M117F-M216F, I43V-M117F-M216L, I43V-M117I-M216A, I43V-M117I-M216F, I43V- M117I-M216L, I43V-M117L-M216A, I43V-M117L-M216F, I43V-M117L-M216L, I43V-M117V-M216A, I43V-M117V-M216F, I43V-M117V-M216L, I43V-M216A, I43V-M216F, I43V-M216L, M122L-N154S- T156A-A29G, M122L-N154S-T156A-A29G-D58P, M122L-N154S-T156A-A29G-Y89A, M122L-N154S- T156A-A29G-M117A, M122L-N154S-T156A-A29G-M117F, M122L-N154S-T156A-A29G-M1171, M122L-N154S-T156A-A29G-M117L, M122L-N154S-T156A-A29G-M117V, M122L-N154S-T156A- A29G-M216A, M122L-N154S-T156A-A29G-M216F, M122L-N154S-T156A-A29G-M216L, M122L- N154S-T156A-A29G-D58P-Y89A, M122L-N154S-T156A-A29G-D58P-M117A, M122L-N154S-T156A- A29G-D58P-M117F, M122L-N154S-T156A-A29G-D58P-M117I, M122L-N154S-T156A-A29G-D58P- M117L,M122L-N154S-T156A-A29G-D58P-M117V, M122L-N154S-T156A-A29G-D58P-M216A, M122L-N154S-T156A-A29G-D58P-M216F, M122L-N154S-T156A-A29G-D58P-M216L, M122L- N154S-T156A-A29G-Y89A-M117A, M122L-N154S-T156A-A29G-Y89A-M117F, M122L-N154S- T156A-A29G-Y89A-M117I, M122L-N154S-T156A-A29G-Y89A-M117L, M122L-N154S-T156A-A29G- Y89A-M117V, M122L-N154S-T156A-A29G-Y89A-M216A, M122L-N154S-T156A-A29G-Y89A-M216F, M122L-N154S-T156A-A29G-Y89A-M216L, M122L-N154S-T156A-A29G-M117A-M216A, M122L- N154S-T156A-A29G-M117A-M216F, M122L-N154S-T156A-A29G-M117A-M216L, M122L-N154S- T156A-A29G-D58P-Y89A-M117A, M122L-N154S-T156A-A29G-D58P-Y89A-M117F, M122L-N154S- T156A-A29G-D58P-Y89A-M1171, M122L-N154S-T156A-A29G-D58P-Y89A-M117L, M122L-N154S- T156A-A29G-D58P-Y89A-M117V, M122L-N154S-T156A-A29G-D58P-Y89A-M216A, M122L-N154S- T156A-A29G-D58P-Y89A-M216F, M122L-N154S-T156A-A29G-D58P-Y89A-M216L, M122L-N154S- T156A-A29G-Y89A-M117A-M216A, M122L-N154S-T156A-A29G-Y89A-M117A-M216F, M122L- N154S-T156A-A29G-Y89A-M117A-M216L,M122L-N154S-T156A-A29G-Y89A-M117F-M216A, M122L-N154S-T156A-A29G-Y89A-M117F-M216F, M122L-N154S-T156A-A29G-Y89A-M117F- M216L, M122L-N154S-T156A-A29G-Y89A-M117I-M216A, M122L-N154S-T156A-A29G-Y89A-M1171- M216F, M122L-N154S-T156A-A29G-Y89A-M117I-M216L, M122L-N154S-T156A-A29G-Y89A-M117L- M216A, M122L-N154S-T156A-A29G-Y89A-M117L-M216F, M122L-N154S-T156A-A29G-Y89A- M117L-M216L, M122L-N154S-T156A-A29G-Y89A-M117V-M216A, M122L-N154S-T156A-A29G- Y89A-M117V-M216F, M122L-N154S-T156A-A29G-Y89A-M117V-M216L, M122L-N154S-T156A- D58P, M122L-N154S-T156A-D58P-Y89A, M122L-N154S-T156A-D58P-M117A, M122L-N154S- T156A-D58P-M117F, M122L-N154S-T156A-D58P-M1171, M122L-N154S-T156A-D58P-M117L, M122L-N154S-T156A-D58P-M117V, M122L-N154S-T156A-D58P-M216A, M122L-N154S-T156A- D58P-M216F, M122L-N154S-T156A-D58P-M216L, M122L-N154S-T156A-D58P-Y89A-M117A, M122L-N154S-T156A-D58P-Y89A-M117F, M122L-N154S-T156A-D58P-Y89A-M117I, M122L-N154S- T156A-D58P-Y89A-M117L, M122L-N154S-T156A-D58P-Y89A-M117V,M122L-N154S-T156A-D58P- Y89A-M216A, M122L-N154S-T156A-D58P-Y89A-M216F, M122L-N154S-T156A-D58P-Y89A-M216L, M122L-N154S-T156A-D58P-M117A-M216A, M122L-N154S-T156A-D58P-M117A-M216F, M122L- N154S-T156A-D58P-M117A-M216L, M122L-N154S-T156A-D58P-M117F-M216A, M122L-N154S- T156A-D58P-M117F-M216F, M122L-N154S-T156A-D58P-M117F-M216L, M122L-N154S-T156A- D58P-M117I-M216A, M122L-N154S-T156A-D58P-M117I-M216F, M122L-N154S-T156A-D58P- M117I-M216L, M122L-N154S-T156A-D58P-M117L-M216A, M122L-N154S-T156A-D58P-M117L- M216F, M122L-N154S-T156A-D58P-M117L-M216L, M122L-N154S-T156A-D58P-M117V-M216A, M122L-N154S-T156A-D58P-M117V-M216F, M122L-N154S-T156A-D58P-M117V-M216L, M122L- N154S-T156A-Y89A, M122L-N154S-T156A-Y89A-M117A, M122L-N154S-T156A-Y89A-M117F, M122L-N154S-T156A-Y89A-M117I, M122L-N154S-T156A-Y89A-M117L, M122L-N154S-T156A- Y89A-M117V, M122L-N154S-T156A-Y89A-M216A, M122L-N154S-T156A-Y89A-M216F, M122L- N154S-T156A-Y89A-M216L, M122L-N154S-T156A-Y89A-M117A-M216A, M122L-N154S-T156A- Y89A-M117A-M216F,M122L-N154S-T156A-Y89A-M117A-M216L, M122L-N154S-T156A-Y89A- M117F-M216A, M122L-N154S-T156A-Y89A-M117F-M216F, M122L-N154S-T156A-Y89A-M117F- M216L, M122L-N154S-T156A-Y89A-M117I-M216A, M122L-N154S-T156A-Y89A-M117I-M216F, M122L-N154S-T156A-Y89A-M117I-M216L, M122L-N154S-T156A-Y89A-M117L-M216A, M122L- N154S-T156A-Y89A-M117L-M216F, M122L-N154S-T156A-Y89A-M117L-M216L, M122L-N154S- T156A-Y89A-M117V-M216A, M122L-N154S-T156A-Y89A-M117V-M216F, M122L-N154S-T156A- Y89A-M117V-M216L, M122L-N154S-T156A-M117A, M122L-N154S-T156A-M117F, M122L-N154S- T156A-M117I, M122L-N154S-T156A-M117L, M122L-N154S-T156A-M117V, M122L-N154S-T156A- M117A-M216A, M122L-N154S-T156A-M117A-M216F, M122L-N154S-T156A-M117A-M216L, M122L- N154S-T156A-M117F-M216A, M122L-N154S-T156A-M117F-M216F, M122L-N154S-T156A-M117F- M216L, M122L-N154S-T156A-M117I-M216A, M122L-N154S-T156A-M117I-M216F, M122L-N154S- T156A-M117I-M216L, M122L-N154S-T156A-M117L-M216A, M122L-N154S-T156A-M117L-M216F, M122L-N154S-T156A-M117L-M216L,M122L-N154S-T156A-M117V-M216A, M122L-N154S-T156A- M117V-M216F, M122L-N154S-T156A-M117V-M216L, M122L-N154S-T156A-M216A, M122L-N154S- T156A-M216F, M122L-N154S-T156A-M216L, M211 N-P212D-A29G, M211 N-P212D-A29G-D58P, M211 N-P212D-A29G-Y89A, M211 N-P212D-A29G-M117A, M211 N-P212D-A29G-M117F, M211 N- P212D-A29G-M1171, M211 N-P212D-A29G-M117L, M211 N-P212D-A29G-M117V, M211 N-P212D- A29G-M216A, M211 N-P212D-A29G-M216F, M211 N-P212D-A29G-M216L, M211 N-P212D-A29G- D58P-Y89A, M211 N-P212D-A29G-D58P-M117A, M211 N-P212D-A29G-D58P-M117F, M211 N- P212D-A29G-D58P-M1171, M211 N-P212D-A29G-D58P-M117L, M211 N-P212D-A29G-D58P-M117V, M211 N-P212D-A29G-D58P-M216A, M211 N-P212D-A29G-D58P-M216F, M211 N-P212D-A29G- D58P-M216L, M211 N-P212D-A29G-Y89A-M117A, M211 N-P212D-A29G-Y89A-M117F, M211 N- P212D-A29G-Y89A-M117I, M211 N-P212D-A29G-Y89A-M117L, M211 N-P212D-A29G-Y89A-M117V, M211 N-P212D-A29G-Y89A-M216A, M211 N-P212D-A29G-Y89A-M216F, M211 N-P212D-A29G-Y89A- M216L, M211 N-P212D-A29G-M117A-M216A,M211 N-P212D-A29G-M117A-M216F, M211 N-P212D- A29G-M117A-M216L, M211 N-P212D-A29G-D58P-Y89A-M117A, M211 N-P212D-A29G-D58P-Y89A- M117F, M211 N-P212D-A29G-D58P-Y89A-M117I, M211 N-P212D-A29G-D58P-Y89A-M117L, M211 N- P212D-A29G-D58P-Y89A-M117V, M211 N-P212D-A29G-D58P-Y89A-M216A, M211 N-P212D-A29G- D58P-Y89A-M216F, M211 N-P212D-A29G-D58P-Y89A-M216L, M211 N-P212D-A29G-Y89A-M117A- M216A, M211 N-P212D-A29G-Y89A-M117A-M216F, M211 N-P212D-A29G-Y89A-M117A-M216L, M211 N-P212D-A29G-Y89A-M117F-M216A, M211 N-P212D-A29G-Y89A-M117F-M216F, M211 N- P212D-A29G-Y89A-M117F-M216L, M211 N-P212D-A29G-Y89A-M117I-M216A, M211 N-P212D-A29— Y89A-M117I-M216F, M211 N-P212D-A29G-Y89A-M117I-M216L, M211 N-P212D-A29G-Y89A-M117L- M216A, M211 N-P212D-A29G-Y89A-M117L-M216F, M211 N-P212D-A29G-Y89A-M117L-M216L, M211 N-P212D-A29G-Y89A-M117V-M216A, M211 N-P212D-A29G-Y89A-M117V-M216F, M211 N- P212D-A29— Y89A-M117V-M216L, M211 N-P212D-D58P, M211 N-P212D-D58P-Y89A, M211 N- P212D-D58P-M117A, M211 N-P212D-D58P-M117F,M211 N-P212D-D58P-M117I, M211 N-P212D- D58P-M117L, M211 N-P212D-D58P-M117V, M211 N-P212D-D58P-M216A, M211 N-P212D-D58P- M216F, M211 N-P212D-D58P-M216L, M211N-P212D-D58P-Y89A-M117A, M211 N-P212D-D58P- Y89A-M117F, M211 N-P212D-D58P-Y89A-M117I, M211 N-P212D-D58P-Y89A-M117L, M211 N- P212D-D58P-Y89A-M117V, M211 N-P212D-D58P-Y89A-M216A, M211 N-P212D-D58P-Y89A-M216F, M211 N-P212D-D58P-Y89A-M216L, M211 N-P212D-D58P-M117A-M216A, M211 N-P212D-D58P- M117A-M216F, M211 N-P212D-D58P-M117A-M216L, M211 N-P212D-D58P-M117F-M216A, M211 N- P212D-D58P-M117F-M216F, M211 N-P212D-D58P-M117F-M216L, M211 N-P212D-D58P-M1171- M216A, M211 N-P212D-D58P-M117I-M216F, M211 N-P212D-D58P-M117I-M216L, M211 N-P212D- D58P-M117L-M216A, M211 N-P212D-D58P-M117L-M216F, M211 N-P212D-D58P-M117L-M216L, M211 N-P212D-D58P-M117V-M216A, M211 N-P212D-D58P-M117V-M216F, M211 N-P212D-D58P- M117V-M216L, M211 N-P212D-Y89A, M211 N-P212D-Y89A-M117A, M211 N-P212D-Y89A-M117F, M211 N-P212D-Y89A-M117I, M211 N-P212D-Y89A-M117L,<h2 style=";text-align:left;direction:ltr">M211 N-P212D-Y89A-M117V, M211 N-P212D-Y89A-M216A, M211 N-P212D-Y89A-M216F, M211 N-P212D-Y89A-M216L, M211 N-P212D-Y89A-M117A-M216A, M211 N-P212D-Y89A-M117A-M216F, M211 N-P212D-Y89A-M117A-M216L, M211 N-P212D-Y89A-M117F-M216A, M211 N-P212D-Y89A-M117F-M216F, M211 N-P212D-Y89A-M117F-M216L, M211 N-P212D-Y89A-M117I-M216A, M211 N-P212D-Y89A-M117I-M216F, M211 N-P212D-Y89A-M117I-M216L, M211 N-P212D-Y89A-M117L-M216A, M211 N-P212D-Y89A-M117L-M216F, M211 N-P212D-Y89A-M117L-M216L, M211 N-P212D-Y89A-M117V-M216A, M211 N-P212D- M211 N-P212D-M117I M211 N-P212D- N-P212D-M117L, M211 N-P212D-M117V, M211 N-P212D- M117A-M216A, M211 N-P212D-M117A-M216F, M117F-M216A, M211 N-P212D-M117F-M216F, M211 N-P212D-M117F-M216L, M211 N-P212D-M1171- M216A, M211 N-P212D-M117I-M216F, M211 N-P212D-M117I-M216L, M211 N-P212D-M117L-M216A, M211 N-P212D-M117L-M216F, M211 N-P212D-M117L-M216L,M211 N-P212D-M117V-M216A, M211 N-P212D-M117V-M216F, M211 N-P212D-M117V-M216L, M211 N-P212D-M216A, M211 N- P212D-M216F, M211 N-P212D-M216L, M211 L-P212D-A29G, M211 L-P212D-A29G-D58P, M211 L- P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D- A29G-M117I, M211 L-P212D-A29G-M117L, M211 L-P212D-A29G-M117V, M211 L-P212D-A29G- M216A, M211 L-P212D-A29G-M216F, M211 L-P212D-A29G-M216L, M211 L-P212D-A29G-D58P- Y89A, M211 L-P212D-A29G-D58P-M117A, M211 L-P212D-A29G-D58P-M117F, M211 L-P212D-A29G- D58P-M117I, M211 L-P212D-A29G-D58P-M117L, M211 L-P212D-A29G-D58P-M117V, M211 L-P212D- A29G-D58P-M216A, M211 L-P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P-M216L, M211 L- P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D-A29G-Y89A-M1171, M211 L-P212D-A29G-Y89A-M117L, M211 L-P212D-A29G-Y89A-M117V, M211 L-P212D-A29G-Y89A- M216A, M211 L-P212D-A29G-Y89A-M216F, M211 L-P212D-A29G-Y89A-M216L, M211 L-P212D- A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F,M211 L-P212D-A29G-M117A-M216L, M211 L-P212D-A29G-D58P-Y89A-M117A, M211 L-P212D-A29G-D58P-Y89A-M117F, M211 L-P212D- A29G-D58P-Y89A-M117I , M211 L-P212D-A29G-D58P-Y89A-M117L, M211 L-P212D-A29G-D58P- Y89A-M117V, M211 L-P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P-Y89A-M216F, M211 L-P212D-A29G-D58P-Y89A-M216L, M211 L-P212D-A29G-Y89A-M117A-M216A, M211 L- P212D-A29G-Y89A-M117A-M216F, M211 L-P212D-A29G-Y89A-M117A-M216L, M211 L-P212D- A29G-Y89A-M117F-M216A, M211 L-P212D-A29G-Y89A-M117F-M216F, M211 L-P212D-A29G-Y89A- M117F-M216L, M211 L-P212D-A29G-Y89A-M117I-M216A, M211 L-P212D-A29G-Y89A-M117I-M216F, M211 L-P212D-A29G-Y89A-M117I-M216L, M211 L-P212D-A29G-Y89A-M117L-M216A, M211 L- P212D-A29G-Y89A-M117L-M216F, M211 L-P212D-A29G-Y89A-M117L-M216L, M211 L-P212D-A29G- Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V-M216F, M211 L-P212D-A29G-Y89A- M117V-M216L, M211 L-P212D-D58P, M211 L-P212D-D58P-Y89A, M211 L-P212D-D58P-M117A, M211 L-P212D-D58P-M117F, M211 L-P212D-D58P-M117I,M211 L-P212D-D58P-M117L, M211 L- P212D-D58P-M117V, M211 L-P212D-D58P-M216A, M211 L-P212D-D58P-M216F, M211 L-P212D- D58P-M216L, M211 L-P212D-D58P-Y89A-M117A, M211 L-P212D-D58P-Y89A-M117F, M211 L- P212D-D58P-Y89A-M1171, M211 L-P212D-D58P-Y89A-M117L, M211 L-P212D-D58P-Y89A-M117V, M211 L-P212D-D58P-Y89A-M216A, M211 L-P212D-D58P-Y89A-M216F, M211 L-P212D-D58P-Y89A- M216L, M211 L-P212D-D58P-M117A-M216A, M211 L-P212D-D58P-M117A-M216F, M211 L-P212D- D58P-M117A-M216L, M211 L-P212D-D58P-M117F-M216A, M211 L-P212D-D58P-M117F-M216F, M211 L-P212D-D58P-M117F-M216L, M211 L-P212D-D58P-M117I-M216A, M211 L-P212D-D58P- M117I-M216F, M211 L-P212D-D58P-M117I-M216L, M211 L-P212D-D58P-M117L-M216A, M211 L- P212D-D58P-M117L-M216F, M211 L-P212D-D58P-M117L-M216L, M211 L-P212D-D58P-M117V- M216A, M211 L-P212D-D58P-M117V-M216F, M211 L-P212D-D58P-M117V-M216L, M211 L-P212D- Y89A, M211 L-P212D-Y89A-M117A, M211 L-P212D-Y89A-M117F, M211 L-P212D-Y89A-M117I, M211 L-P212D-Y89A-M117L, M211 L-P212D-Y89A-M117V,M211 L-P212D-Y89A-M216A, M211 L- P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L, M211 L-P212D-Y89A-M117A-M216A, M211 L- P212D-Y89A-M117A-M216F, M211 L-P212D-Y89A-M117A-M216L, M211 L-P212D-Y89A-M117F- M216A, M211 L-P212D-Y89A-M117F-M216F, M211 L-P212D-Y89A-M117F-M216L, M211 L-P212D- Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A-M117L-M216A, M211 L-P212D-Y89A-M117L-M216F, M211 L-P212D-Y89A- M117L-M216L, M211 L-P212D-Y89A-M117V-M216A, M211 L-P212D-Y89A-M117V-M216F, M211 L- P212D-Y89A-M117V-M216L, M211 L-P212D-M117A, M211 L-P212D-M117F, M211 L-P212D-M117I, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L-P212D-M117A- M216F, M211 L-P212D-M117A-M216L, M211 L-P212D-M117F-M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L- P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L-P212D-M117L-M216F, M211 L-P212D- M117L-M216L, M211 L-P212D-M117V-M216A,M211 L-P212D-M117V-M216F, M211 L-P212D-M117V- M216L, M211 L-P212D-M216A, M211 L-P212D-M216F, M211 L-P212D-M216L, G160S-A29G, G160S- A29G-D58P, G160S-A29G-Y89A, G160S-A29G-M117A, G160S-A29G-M117F, G160S-A29G-M1171, G160S-A29G-M117L, G160S-A29G-M117V, G160S-A29G-M216A, G160S-A29G-M216F, G160S-A29G-M216L, G160S-A29G-D58P-Y89A, G160S-A29G-D58P-M117A, G160S-A29G-D58P-M117F, G160S-A29G-D58P-M1171, G160S-A29G-D58P-M117L, G160S-A29G-D58P-M117V, G160S-A29G-D58P-M216A, G160S-A29G-D58P-M216F, G160S-A29G-D58P-M216L, G160S-A29G-Y89A-M117A, G160S-A29G-Y89A-M117F, G160S-A29G-Y89A-M1171, G160S-A29G-Y89A-M117L, G160S-A29G-Y89A-M117V, G160S-A29G-Y89A-M216A, G160S-A29G-Y89A-M216F, G160S-A29G-Y89A-M216L, G160S-A29G-M117A-M216A, G160S-A29G-M117A-M216F, G160S-A29G-M117A-M216L, G160S-A29G-D58P-Y89A-M117A, G160S-A29G-D58P-Y89A-M117F, G160S-A29G-D58P-Y89A-M117I, G160S-A29G-D58P-Y89A-M117L, G160S-A29G-D58P-Y89A-M117V, G160S-A29G-D58P-Y89A-M216A, G160S-A29G-D58P-Y89A-M216F, G160S-A29G-D58P-Y89A-M216L,G160S-A29G-Y89A- M117A-M216A, G160S-A29G-Y89A-M117A-M216F, G160S-A29G-Y89A-M117A-M216L, G160S- A29G-Y89A-M117F-M216A, G160S-A29G-Y89A-M117F-M216F, G160S-A29G-Y89A-M117F-M216L, G160S-A29G-Y89A-M117I-M216A, G160S-A29G-Y89A-M117I-M216F, G160S-A29G-Y89A-M1171- M216L, G160S-A29G-Y89A-M117L-M216A, G160S-A29G-Y89A-M117L-M216F, G160S-A29G-Y89A- M117L-M216L, G160S-A29G-Y89A-M117V-M216A, G160S-A29G-Y89A-M117V-M216F, G160S- A29G-Y89A-M117V-M216L, G160S-D58P, G160S-D58P-Y89A, G160S-D58P-M117A, G160S-D58P- M117F, G160S-D58P-M1171, G160S-D58P-M117L, G160S-D58P-M117V, G160S-D58P-M216A, G160S-D58P-M216F, G160S-D58P-M216L, G160S-D58P-Y89A-M117A, G160S-D58P-Y89A-M117F, G160S-D58P-Y89A-M1171, G160S-D58P-Y89A-M117L, G160S-D58P-Y89A-M117V, G160S-D58P- Y89A-M216A, G160S-D58P-Y89A-M216F, G160S-D58P-Y89A-M216L, G160S-D58P-M117A-M216A, G160S-D58P-M117A-M216F, G160S-D58P-M117A-M216L, G160S-D58P-M117F-M216A, G160S- D58P-M117F-M216F, G160S-D58P-M117F-M216L, G160S-D58P-M117I-M216A, G160S-D58P- M117I-M216F,G160S-D58P-M117I-M216L, G160S-D58P-M117L-M216A, G160S-D58P-M117L- M216F, G160S-D58P-M117L-M216L, G160S-D58P-M117V-M216A, G160S-D58P-M117V-M216F, G160S-D58P-M117V-M216L, G160S-Y89A, G160S-Y89A-M117A, G160S-Y89A-M117F, G160S- Y89A-M117I, G160S-Y89A-M117L, G160S-Y89A-M117V, G160S-Y89A-M216A, G160S-Y89A- M216F, G160S-Y89A-M216L, G160S-Y89A-M117A-M216A, G160S-Y89A-M117A-M216F, G160S- Y89A-M117A-M216L, G160S-Y89A-M117F-M216A, G160S-Y89A-M117F-M216F, G160S-Y89A- M117F-M216L, G160S-Y89A-M117I-M216A, G160S-Y89A-M117I-M216F, G160S-Y89A-M1171- M216L, G160S-Y89A-M117L-M216A, G160S-Y89A-M117L-M216F, G160S-Y89A-M117L-M216L, G160S-Y89A-M117V-M216A, G160S-Y89A-M117V-M216F, G160S-Y89A-M117V-M216L, G160S- M117A, G160S-M117F, G160S-M117I, G160S-M117L, G160S-M117V, G160S-M117A-M216A, G160S-M117A-M216F, G160S-M117A-M216L, G160S-M117F-M216A, G160S-M117F-M216F, G160S-M117F-M216L, G160S-M117I-M216A, G160S-M117I-M216F, G160S-M117I-M216L, G160S- M117L-M216A, G160S-M117L-M216F, G160S-M117L-M216L,G160S-M117V-M216A, G160S- M117V-M216F, G160S-M117V-M216L, G160S-M216A, G160S-M216F, G160S-M216L, D127P- M211 L-P212D-A29G, D127P-M211 L-P212D-A29G-D58P, D127P-M211 L-P212D-A29G-Y89A, D127P-M211 L-P212D-A29G-M117A, D127P-M211 L-P212D-A29G-M117F, D127P-M211 L-P212D- A29G-M117I, D127P-M211 L-P212D-A29G-M117L, D127P-M211 L-P212D-A29G-M117V, D127P- M211 L-P212D-A29G-M216A, D127P-M211 L-P212D-A29G-M216F, D127P-M211 L-P212D-A29G- M216L, D127P-M211 L-P212D-A29G-D58P-Y89A, D127P-M211 L-P212D-A29G-D58P-M117A, D127P-M211 L-P212D-A29G-D58P-M117F, D127P-M211 L-P212D-A29G-D58P-M1171, D127P- M211 L-P212D-A29G-D58P-M117L, D127P-M211 L-P212D-A29G-D58P-M117V, D127P-M211 L- P212D-A29G-D58P-M216A, D127P-M211 L-P212D-A29G-D58P-M216F, D127P-M211 L-P212D- A29G-D58P-M216L, D127P-M211 L-P212D-A29G-Y89A-M117A, D127P-M211 L-P212D-A29G-Y89A- M117F, D127P-M211 L-P212D-A29G-Y89A-M1171, D127P-M211 L-P212D-A29G-Y89A-M117L, D127P-M211 L-P212D-A29G-Y89A-M117V, D127P-M211 L-P212D-A29G-Y89A-M216A,D127P- M211 L-P212D-A29G-Y89A-M216F, D127P-M211 L-P212D-A29G-Y89A-M216L, D127P-M211 L- P212D-A29G-M117A-M216A, D127P-M211 L-P212D-A29G-M117A-M216F, D127P-M211 L-P212D- A29G-M117A-M216L, D127P-M211 L-P212D-A29G-D58P-Y89A-M117A, D127P-M211 L-P212D- A29G-D58P-Y89A-M117F, D127P-M211 L-P212D-A29G-D58P-Y89A-M1171, D127P-M211 L-P212D- A29G-D58P-Y89A-M117L, D127P-M211 L-P212D-A29G-D58P-Y89A-M117V, D127P-M211 L-P212D- A29G-D58P-Y89A-M216A, D127P-M211 L-P212D-A29G-D58P-Y89A-M216F, D127P-M211 L-P212D- A29G-D58P-Y89A-M216L, D127P-M211 L-P212D-A29G-Y89A-M117A-M216A, D127P-M211 L- P212D-A29G-Y89A-M117A-M216F, D127P-M211 L-P212D-A29G-Y89A-M117A-M216L, D127P- M211 L-P212D-A29G-Y89A-M117F-M216A, D127P-M211 L-P212D-A29G-Y89A-M117F-M216F, D127P-M211 L-P212D-A29G-Y89A-M117F-M216L, D127P-M211 L-P212D-A29G-Y89A-M117I-M216A, D127P-M211 L-P212D-A29— Y89A-M117I-M216F, D127P-M211 L-P212D-A29G-Y89A-M117I-M216L, D127P-M211 L-P212D-A29G-Y89A-M117L-M216A, D127P-M211 L-P212D-A29G-Y89A-M117L- M216F,D127P-M211 L-P212D-A29G-Y89A-M117L-M216L, D127P-M211 L-P212D-A29G-Y89A- M117V-M216A, D127P-M211 L-P212D-A29G-Y89A-M117V-M216F, D127P-M211 L-P212D-A29G- Y89A-M117V-M216L, D127P-M211 L-P212D-D58P, D127P-M211 L-P212D-D58P-Y89A, D127P- M211 L-P212D-D58P-M117A, D127P-M211 L-P212D-D58P-M117F, D127P-M211 L-P212D-D58P- M117I, D127P-M211 L-P212D-D58P-M117L, D127P-M211 L-P212D-D58P-M117V, D127P-M211 L- P212D-D58P-M216A, D127P-M211 L-P212D-D58P-M216F, D127P-M211 L-P212D-D58P-M216L, D127P-M211 L-P212D-D58P-Y89A-M117A, D127P-M211 L-P212D-D58P-Y89A-M117F, D127P-,

[0077] M211 L-P212D-D58P-Y89A-M1171, D127P-M211 L-P212D-D58P-Y89A-M117L, D127P-M211 L-P212D- D58P-Y89A-M117V, D127P-M211 L-P212D-D58P-Y89A-M216A, D127P-M211 L-P212D-D58P-Y89A- M216F, D127P-M211 L-P212D-D58P-Y89A-M216L, D127P-M211 L-P212D-D58P-M117A-M216A, D127P-M211 L-P212D-D58P-M117A-M216F, D127P-M211 L-P212D-D58P-M117A-M216L, D127P- M211 L-P212D-D58P-M117F-M216A, D127P-M211 L-P212D-D58P-M117F-M216F, D127P-M211 L- P212D-D58P-M117F-M216L, D127P-M211 L-P212D-D58P-M117I-M216A, D127P-M211 L-P212D- D58P-M117I-M216F, D127P-M211 L-P212D-D58P-M117I-M216L, D127P-M211 L-P212D-D58P- M117L-M216A, D127P-M211 L-P212D-D58P-M117L-M216F, D127P-M211 L-P212D-D58P-M117L- M216L, D127P-M211 L-P212D-D58P-M117V-M216A, D127P-M211 L-P212D-D58P-M117V-M216F, D127P-M211 L-P212D-D58P-M117V-M216L, D127P-M211 L-P212D-Y89A, D127P-M211 L-P212D- Y89A-M117A, D127P-M211 L-P212D-Y89A-M117F, D127P-M211 L-P212D-Y89A-M1171, D127P- M211 L-P212D-Y89A-M117L, D127P-M211 L-P212D-Y89A-M117V, D127P-M211 L-P212D-Y89A- M216A,<h2 style=";text-align:left;direction:ltr">D127P-M211 L-P212D-Y89A-M216F, D127P-M211 L-P212D-Y89A-M216L, D127P-M211 L- P212D-Y89A-M117A-M216A, D127P-M211 L-P212D-Y89A-M117A-M216F, D127P-M211 L-P212D- Y89A-M117A-M216L, D127P-M211 L-P212D-Y89A-M117F-M216A, D127P-M211 L-P212D-Y89A- M117F-M216F, D127P-M211 L-P212D-Y89A-M117F-M216L, D127P-M211 L-P212D-Y89A-M1171- M216A, D127P-M211 L-P212D-Y89A-M117I-M216F, D127P-M211 L-P212D-Y89A-M117I-M216L, D127P-M211 L-P212D-Y89A-M117L-M216A, D127P-M211 L-P212D-Y89A-M117L-M216F, D127P- M211 L-P212D-Y89A-M117L-M216L, D127P-M211 L-P212D-Y89A-M117V-M216A, D127P-M211 L- P212D-Y89A-M117V-M216F, D127P-M211 L-P212D-Y89A-M117V-M216L, L-P212D- D127P-M211 M117A, D127P-M211 L-P212D-M117F, D127P-M211 L-P212D-M1171, D127P-M211 L-P212D-M117L, D127P-M211 L-P212D-M117A-M216A, D127P-M211 L-P212D-M117A- M216F, D127P-M211 L-P212D-M117A-M216L, D127P-M211 L-P212D-M117F-M216A, D127P-M211 L- P212D-M117F-M216F, D127P-M211 L-P212D-M117F-M216L, D127P-M211 L-P212D-M117I-M216A,D127P-M211 L-P212D-M117I-M216F, D127P-M211 L-P212D-M117I-M216L, D127P-M211 L-P212D- M117L-M216A, D127P-M211 L-P212D-M117L-M216F, D127P-M211 L-P212D-M117L-M216L, D127P- M211 L-P212D-M117V-M216A, D127P-M211 L-P212D-M117V-M216F, D127P-M211 L-P212D-M117V- M216L, D127P-M211 L-P212D-M216A, D127P-M211 L-P212D-M216F, D127P-M211 L-P212D-M216L, P212H-A29G, P212H-A29G-D58P, P212H-A29G-Y89A, P212H-A29G-M117A, P212H-A29G-M117F, P212H-A29G-M1171, P212H-A29G-M117L, P212H-A29G-M117V, P212H-A29G-M216A, P212H- A29G-M216F, P212H-A29G-M216L, P212H-A29G-D58P-Y89A, P212H-A29G-D58P-M117A, P212H- A29G-D58P-M117F, P212H-A29G-D58P-M1171, P212H-A29G-D58P-M117L, P212H-A29G-D58P- M117V, P212H-A29G-D58P-M216A, P212H-A29G-D58P-M216F, P212H-A29G-D58P-M216L, P212H-A29G-Y89A-M117A, P212H-A29G-Y89A-M117F, P212H-A29G-Y89A-M1171, P212H-A29G- Y89A-M117L, P212H-A29G-Y89A-M117V, P212H-A29G-Y89A-M216A, P212H-A29G-Y89A-M216F, P212H-A29G-Y89A-M216L, P212H-A29G-M117A-M216A, P212H-A29G-M117A-M216F, P212H- A29G-M117A-M216L,P212H-A29G-D58P-Y89A-M117A, P212H-A29G-D58P-Y89A-M117F, P212H- A29G-D58P-Y89A-M1171, P212H-A29G-D58P-Y89A-M117L, P212H-A29G-D58P-Y89A-M117V, P212H-A29G-D58P-Y89A-M216A, P212H-A29G-D58P-Y89A-M216F, P212H-A29G-D58P-Y89A- M216L, P212H-A29G-Y89A-M117A-M216A, P212H-A29G-Y89A-M117A-M216F, P212H-A29G-Y89A- M117A-M216L, P212H-A29G-Y89A-M117F-M216A, P212H-A29G-Y89A-M117F-M216F, P212H- A29G-Y89A-M117F-M216L, P212H-A29G-Y89A-M117I-M216A, P212H-A29G-Y89A-M117I-M216F, P212H-A29G-Y89A-M117I-M216L, P212H-A29G-Y89A-M117L-M216A, P212H-A29G-Y89A-M117L- M216F, P212H-A29G-Y89A-M117L-M216L, P212H-A29G-Y89A-M117V-M216A, P212H-A29G-Y89A- M117V-M216F, P212H-A29G-Y89A-M117V-M216L, P212H-D58P, P212H-D58P-Y89A, P212H-D58P- M117A, P212H-D58P-M117F, P212H-D58P-M1171, P212H-D58P-M117L, P212H-D58P-M117V, P212H-D58P-M216A, P212H-D58P-M216F, P212H-D58P-M216L, P212H-D58P-Y89A-M117A, P212H-D58P-Y89A-M117F, P212H-D58P-Y89A-M1171, P212H-D58P-Y89A-M117L, P212H-D58P- Y89A-M117V, P212H-D58P-Y89A-M216A, P212H-D58P-Y89A-M216F,P212H-D58P-Y89A-M216L, P212H-D58P-M117A-M216A, P212H-D58P-M117A-M216F, P212H-D58P-M117A-M216L, P212H- D58P-M117F-M216A, P212H-D58P-M117F-M216F, P212H-D58P-M117F-M216L, P212H-D58P- M117I-M216A, P212H-D58P-M117I-M216F, P212H-D58P-M117I-M216L, P212H-D58P-M117L- M216A, P212H-D58P-M117L-M216F, P212H-D58P-M117L-M216L, P212H-D58P-M117V-M216A, P212H-D58P-M117V-M216F, P212H-D58P-M117V-M216L, P212H-Y89A, P212H-Y89A-M117A, P212H-Y89A-M117F, P212H-Y89A-M1171, P212H-Y89A-M117L, P212H-Y89A-M117V, P212H-Y89A- M216A, P212H-Y89A-M216F, P212H-Y89A-M216L, P212H-Y89A-M117A-M216A, P212H-Y89A- M117A-M216F, P212H-Y89A-M117A-M216L, P212H-Y89A-M117F-M216A, P212H-Y89A-M117F- M216F, P212H-Y89A-M117F-M216L, P212H-Y89A-M117I-M216A, P212H-Y89A-M117I-M216F, P212H-Y89A-M117I-M216L, P212H-Y89A-M117L-M216A, P212H-Y89A-M117L-M216F, P212H- Y89A-M117L-M216L, P212H-Y89A-M117V-M216A, P212H-Y89A-M117V-M216F, P212H-Y89A- M117V-M216L, P212H-M117A, P212H-M117F, P212H-M1171, P212H-M117L, P212H-M117V, P212H-M117A-M216A,<h2 style=";text-align:left;direction:ltr">P212H-M117A-M216F, P212H-M117A-M216L, P212H-M117F-M216A, P212H-M117F-M216F, P212H-M117F-M216L, P212H-M117I-M216A, P212H-M117I-M216F, P212H- M117I-M216L, P212H-M117L-M216A, P212H-M117L-M216F, P212H-M117L-M216L, P212H-M117V- M216A, P212H-M117V-M216F, P212H-M117V-M216L, P212H-M216A, P212H-M216F, P212H-M216L, Q12L-M122L-A222S-A29G, Q12L-M122L-A222S-A29G-D58P, Q12L-M122L-A222S-A29G-Y89A, Q12L-M122L-A222S-A29G-M117A, Q12L-M122L-A222S-A29G-M117F, Q12L-M122L-A222S-A29G-M117I, Q12L-M122L-A222S-A29G-M117L, Q12L-M122L-A222S-A29G-M117V, Q12L-M122L- A222S-A29G-M216A, Q12L-M122L-A222S-A29G-M216F, Q12L-M122L-A222S-A29G-M216L, Q12L- M122L-A222S-A29G-D58P-Y89A, Q12L-M122L-A222S-A29G-D58P-M117A, Q12L-M122L-A222S- A29G-D58P-M117F, Q12L-M122L-A222S-A29G-D58P-M117I, Q12L-M122L-A222S-A29G-D58P-M117L, Q12L-M122L-A222S-A29G-D58P-M117V, Q12L-M122L-A222S-A29G-D58P-M216A, Q12L- M122L-A222S-A29G-D58P-M216F, Q12L-M122L-A222S-A29G-D58P-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A, Q12L-M122L-A222S-A29G-Y89A-M117F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117I, Q12L-M122L-A222S-A29G-Y89A-M117L, Q12L-M122L-A222S-A29G-Y89A-M117V, Q12L- M122L-A222S-A29G-Y89A-M216A, Q12L-M122L-A222S-A29G-Y89A-M216F, Q12L-M122L-A222S-A29G-Y89A-M216L, Q12L-M122L-A222S-A29G-M117A-M216A, Q12L-M122L-A222S-A29G-M117A-M216F, Q12L-M122L-A222S-A29G-M117A-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117A, Q12L-M122L-A222S-A29G-D58P-Y89A-M117F, Q12L-M122L-A222S-A29G-D58P-Y89A-M1171, Q12L-M122L-A222S-A29G-D58P-Y89A-M117L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117V, Q12L-M122L-A222S-A29G-D58P-Y89A-M216A, Q12L-M122L-A222S-A29G-D58P-Y89A-M216F, Q12L-M122L-A222S-A29G-D58P-Y89A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A-M216A, Q12L-M122L-A222S-A29G-Y89A-M117A-M216F, Q12L-M122L-A222S-A29G-Y89A-M117A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117F-M216A, Q12L-M122L-A222S-A29G-Y89A-M117F-M216F, Q12L-M122L-A222S-A29G-Y89A-M117F-M216L, Q12L-M122L-A222S-A29G-Y89A-M117I-M216A, Q12L-M122L-A222S-A29G-Y89A-M117I-M216F, Q12L-M122L-A222S-A29G-Y89A-M117I-M216L,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117L-M216A, Q12L-M122L-A222S-A29G-Y89A-M117L-M216F, Q12L-M122L-A222S-A29G-Y89A-M117L-M216L, Q12L-M122L-A222S-A29G-Y89A-M117V-M216A, Q12L-M122L-A222S-A29G-Y89A-M117V-M216F, Q12L-M122L-A222S-A29G-Y89A-M117V-M216L, Q12L-M122L-A222S-D58P, Q12L-M122L-A222S-D58P-Y89A, Q12L-M122L-A222S-D58P-M117A, Q12L-M122L-A222S-D58P-M117F, Q12L-M122L-A222S-D58P-M1171, Q12L-M122L-A222S-D58P- M117L, Q12L-M122L-A222S-D58P-M117V, Q12L-M122L-A222S-D58P-M216A, Q12L-M122L-A222S- D58P-M216F, Q12L-M122L-A222S-D58P-M216L, Q12L-M122L-A222S-D58P-Y89A-M117A, Q12L- M122L-A222S-D58P-Y89A-M117F, Q12L-M122L-A222S-D58P-Y89A-M1171, Q12L-M122L-A222S- D58P-Y89A-M117L, Q12L-M122L-A222S-D58P-Y89A-M117V, Q12L-M122L-A222S-D58P-Y89A-M216A, Q12L-M122L-A222S-D58P-Y89A-M216F, Q12L-M122L-A222S-D58P-Y89A-M216L, Q12L- M122L-A222S-D58P-M117A-M216A, Q12L-M122L-A222S-D58P-M117A-M216F, Q12L-M122L- A222S-D58P-M117A-M216L, Q12L-M122L-A222S-D58P-M117F-M216A, Q12L-M122L-A222S-D58P- M117F-M216F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-D58P-M117F-M216L, Q12L-M122L-A222S-D58P-M1171- M216A, Q12L-M122L-A222S-D58P-M117I-M216F, Q12L-M122L-A222S-D58P-M117I-M216L, Q12L- M122L-A222S-D58P-M117L-M216A, Q12L-M122L-A222S-D58P-M117L-M216F, Q12L-M122L- A222S-D58P-M117L-M216L, Q12L-M122L-A222S-D58P-M117V-M216A, Q12L-M122L-A222S-D58P-M117V-M216F, Q12L-M122L-A222S-D58P-M117V-M216L, Q12L-M122L-A222S-Y89A, Q12L-M122L-A222S-Y89A-M117A, Q12L-M122L-A222S-Y89A-M117F, Q12L-M122L-A222S-Y89A-M1171, Q12L-M122L-A222S-Y89A-M117L, Q12L-M122L-A222S-Y89A-M117V, Q12L-M122L-A222S-Y89A-M216A, Q12L-M122L-A222S-Y89A-M216F, Q12L-M122L-A222S-Y89A-M216L, Q12L-M122L-A222S-Y89A-M117A-M216A, Q12L-M122L-A222S-Y89A-M117A-M216F, Q12L-M122L-A222S-Y89A-M117A-M216L, Q12L-M122L-A222S-Y89A-M117F-M216A, Q12L-M122L-A222S-Y89A-M117F-M216F, Q12L- M122L-A222S-Y89A-M117F-M216L, Q12L-M122L-A222S-Y89A-M117I-M216A, Q12L-M122L-A222S-Y89A-M117I-M216F, Q12L-M122L-A222S-Y89A-M117I-M216L, Q12L-M122L-A222S-Y89A-M117L-M216A, Q12L-M122L-A222S-Y89A-M117L-M216F,Q12L-M122L-A222S-Y89A-M117L-M216L, Q12L- M122L-A222S-Y89A-M117V-M216A, Q12L-M122L-A222S-Y89A-M117V-M216F, Q12L-M122L- A222S-Y89A-M117V-M216L, Q12L-M122L-A222S-M117A, Q12L-M122L-A222S-M117F, Q12L-M122L-A222S-M1171, Q12L-M122L-A222S-M117L, Q12L-M122L-A222S-M117V, Q12L-M122L-A222S-M117A-M216A, Q12L-M122L-A222S-M117A-M216F, Q12L-M122L-A222S-M117A-M216L, Q12L-M122L-A222S-M117F-M216A, Q12L-M122L-A222S-M117F-M216F, Q12L-M122L-A222S-M117F-M216L, Q12L-M122L-A222S-M117I-M216A, Q12L-M122L-A222S-M117I-M216F, Q12L-M122L-A222S-M117I-M216L, Q12L-M122L-A222S-M117L-M216A, Q12L-M122L-A222S-M117L-M216F, Q12L-M122L-A222S-M117L-M216L, Q12L-M122L-A222S-M117V-M216A, Q12L-M122L-A222S-M117V-M216F, Q12L-M122L-A222S-M117V-M216L, Q12L-M122L-A222S-M216A, Q12L-M122L-A222S-M216F, Q12L-M122L-A222S-M216L, wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents,preferably machine dishwashing detergents, particularly preferably machine dishwashing detergents containing bleach, the stability being determined as described in Example 3.

[0078] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which consists of the one selected from M211 L-P212D-A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L-P212D-A29G-M117V, M211 L-P212D-A29G-M216A, M211 L-P212D-A29G- M216F, M211 L-P212D-A29G-M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P- M117A,M211 L-P212D-A29G-D58P-M117F, M211 L-P212D-A29G-D58P-M117I, M211 L-P212D- A29G-D58P-M117L, M211 L-P212D-A29G-D58P-M117V, M211 L-P212D-A29G-D58P-M216A, M211 L- P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P-M216L, M211 L-P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211L-P212D-A29G-Y89A-M117I, M211 L-P212D-A29G-Y89A- M117L, M211 L-P212D-A29G-Y89A-M117V, M211 L-P212D-A29G-Y89A-M216A, M211 L-P212D- A29G-Y89A-M216F, M211 L-P212D-A29G-Y89A-M216L, M211 L-P212D-A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F, M211 L-P212D-A29G-M117A-M216L, M211 L-P212D-A29G- D58P-Y89A-M117A, M211 L-P212D-A29G-D58P-Y89A-M117F, M211 L-P212D-A29G-D58P-Y89A- M117I, M211 L-P212D-A29G-D58P-Y89A-M117L, M211 L-P212D-A29G-D58P-Y89A-M117V, M211 L- P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P-Y89A-M216F, M211 L-P212D-A29G- D58P-Y89A-M216L, M211 L-P212D-A29G-Y89A-M117A-M216A, M211 L-P212D-A29G-Y89A-M117A- M216F, M211 L-P212D-A29G-Y89A-M117A-M216L, M211 L-P212D-A29G-Y89A-M117F-M216A,M211 L-P212D-A29G-Y89A-M117F-M216F, M211 L-P212D-A29G-Y89A-M117F-M216L, M211 L- P212D-A29G-Y89A-M117I-M216A, M211 L-P212D-A29G-Y89A-M117I-M216F, M211 L-P212D-A29G- Y89A-M117I-M216L, M211 L-P212D-A29G-Y89A-M117L-M216A, M211 L-P212D-A29G-Y89A-M117L- M216F, M211 L-P212D-A29G-Y89A-M117L-M216L, M211 L-P212D-A29G-Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V-M216F, M211 L-P212D-A29G-Y89A-M117V-M216L, M211 L- P212D-D58P, M211 L-P212D-D58P-Y89A, M211 L-P212D-D58P-M117A, M211 L-P212D-D58P- M117F, M211 L-P212D-D58P-M117I, M211 L-P212D-D58P-M117L, M211 L-P212D-D58P-M117V, M211 L-P212D-D58P-M216A, M211 L-P212D-D58P-M216F, M211 L-P212D-D58P-M216L, M211 L- P212D-D58P-Y89A-M117A, M211 L-P212D-D58P-Y89A-M117F, M211 L-P212D-D58P-Y89A-M1171, M211 L-P212D-D58P-Y89A-M117L, M211 L-P212D-D58P-Y89A-M117V, M211 L-P212D-D58P-Y89A- M216A, M211 L-P212D-D58P-Y89A-M216F, M211 L-P212D-D58P-Y89A-M216L, M211 L-P212D- D58P-M117A-M216A, M211 L-P212D-D58P-M117A-M216F, M211 L-P212D-D58P-M117A-M216L,M211 L-P212D-D58P-M117F-M216A, M211 L-P212D-D58P-M117F-M216F, M211 L-P212D-D58P- M117F-M216L, M211 L-P212D-D58P-M117I-M216A, M211 L-P212D-D58P-M117I-M216F, M211 L- P212D-D58P-M117I-M216L, M211 L-P212D-D58P-M117L-M216A, M211 L-P212D-D58P-M117L- M216F, M211 L-P212D-D58P-M117L-M216L, M211 L-P212D-D58P-M117V-M216A, M211 L-P212D- D58P-M117V-M216F, M211 L-P212D-D58P-M117V-M216L, M211 L-P212D-Y89A, M211 L-P212D- Y89A-M117A, M211 L-P212D-Y89A-M117F, M211 L-P212D-Y89A-M1171, M211 L-P212D-Y89A- M117L, M211 L-P212D-Y89A-M117V, M211 L-P212D-Y89A-M216A, M211 L-P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L, M211 L-P212D-Y89A-M117A-M216A, M211 L-P212D-Y89A-M117A- M216F, M211 L-P212D-Y89A-M117A-M216L, M211 L-P212D-Y89A-M117F-M216A, M211 L-P212D- Y89A-M117F-M216F, M211 L-P212D-Y89A-M117F-M216L, M211 L-P212D-Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A- M117L-M216A, M211 L-P212D-Y89A-M117L-M216F, M211 L-P212D-Y89A-M117L-M216L,M211 L-P212D-Y89A-M117V-M216A, M211 L-P212D-Y89A-M117V-M216F, M211 L-P212D-Y89A-M117V- M216L, M211 L-P212D-M117A, M211 L-P212D-M117F, M211 L-P212D-M117I, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L-P212D-M117A-M216F, M211 L-P212D- M117A-M216L, M211 L-P212D-M117F-M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L-P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L-P212D-M117L-M216F, M211 L-P212D-M117L-M216L, M211 L P212D-M117V-M216A, M211 L-P212D-M117V-M216F, M211 L-P212D-M117V-M216L, M211 L-P212D-M216A, M211 L-P212D-M216F, M211 L-P212D-M216L, wherein the protease has improved stability in washing or cleaning agents, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing detergents, particularly preferably automatic dishwashing detergents containing bleach,the stability being determined as described in Example 3.,

[0079] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which is selected from the group consisting of M117A-M211 L-P212D, Y89A-M117A-M211 L-P212D, M117V-M211 L-P212D, A29G-M117V- M211 L-P212D, M117F-M211 L-P212D, M117I-M211 L-P212D, M117L-M211 L-P212D, M211 L-P212D- M216F, D58P-M211 L-P212D-M216A and M211 L-P212D-M216L, wherein the protease has improved stability in washing or cleaning agents,in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing detergents, particularly preferably bleach-containing automatic dishwashing detergents, the stability being determined as described in Example 3.

[0080] In particularly preferred embodiments, the protease according to the invention comprises an amino acid substitution combination selected from the group consisting of I43V-A29G, I43V-A29G-D58P, I43V-A29G-Y89A, I43V-A29G-M117A, I43V-A29G-M117F, I43V-A29G-M117I, I43V-A29G-M117L, I43V-A29G-M117V, I43V-A29G-M216A, I43V-A29G-M216F, I43V-A29G-M216L, I43V-A29G-D58P-Y89A, I43V-A29G-D58P-M117A, I43V-A29G-D58P-M117F, I43V-A29G-D58P-M1171, I43V-A29G-D58P-M117L, I43V-A29G-D58P-M117V, I43V-A29G-D58P-M216A, I43V-A29G-D58P-M216F, I43V-A29G-D58P- M216L, I43V-A29G-Y89A-M117A, I43V-A29G-Y89A-M117F, I43V-A29G-Y89A-M1171, I43V-A29G- Y89A-M117L, I43V-A29G-Y89A-M117V, I43V-A29G-Y89A-M216A, I43V-A29G-Y89A-M216F, I43V-A29G-Y89A-M216L, I43V-A29G-M117A-M216A, I43V-A29G-M117A-M216F, I43V-A29G-M117A- M216L, I43V-A29G-D58P-Y89A-M117A, I43V-A29G-D58P-Y89A-M117F, I43V-A29G-D58P-Y89A- M117I, I43V-A29G-D58P-Y89A-M117L, I43V-A29G-D58P-Y89A-M117V, I43V-A29G-D58P-Y89A-M216A, I43V-A29G-D58P-Y89A-M216F, I43V-A29G-D58P-Y89A-M216L,I43V-A29G-Y89A-M117A- M216A, I43V-A29G-Y89A-M117A-M216F, I43V-A29G-Y89A-M117A-M216L, I43V-A29G-Y89A- M117F-M216A, I43V-A29G-Y89A-M117F-M216F, I43V-A29G-Y89A-M117F-M216L, I43V-A29G- Y89A-M117I-M216A, I43V-A29G-Y89A-M117I-M216F, I43V-A29G-Y89A-M117I-M216L, I43V-A29G- Y89A-M117L-M216A, I43V-A29G-Y89A-M117L-M216F, I43V-A29G-Y89A-M117L-M216L, I43V- A29G-Y89A-M117V-M216A, I43V-A29G-Y89A-M117V-M216F, I43V-A29G-Y89A-M117V-M216L, I43V-D58P, I43V-D58P-Y89A, I43V-D58P-M117A, I43V-D58P-M117F, I43V-D58P-M1171, I43V-D58P- M117L, I43V-D58P-M117V, I43V-D58P-M216A, I43V-D58P-M216F, I43V-D58P-M216L, I43V-D58P- Y89A-M117A, I43V-D58P-Y89A-M117F, I43V-D58P-Y89A-M1171, I43V-D58P-Y89A-M117L, I43V- D58P-Y89A-M117V, I43V-D58P-Y89A-M216A, I43V-D58P-Y89A-M216F, I43V-D58P-Y89A-M216L, I43V-D58P-M117A-M216A, I43V-D58P-M117A-M216F, I43V-D58P-M117A-M216L, I43V-D58P- M117F-M216A, I43V-D58P-M117F-M216F, I43V-D58P-M117F-M216L, I43V-D58P-M117I-M216A, I43V-D58P-M117I-M216F, I43V-D58P-M117I-M216L, I43V-D58P-M117L-M216A,I43V-D58P-M117L- M216F, I43V-D58P-M117L-M216L, I43V-D58P-M117V-M216A, I43V-D58P-M117V-M216F, I43V- D58P-M117V-M216L, I43V-Y89A, I43V-Y89A-M117A, I43V-Y89A-M117F, I43V-Y89A-M1171, I43V- Y89A-M117L, I43V-Y89A-M117V, I43V-Y89A-M216A, I43V-Y89A-M216F, I43V-Y89A-M216L, I43V- Y89A-M117A-M216A, I43V-Y89A-M117A-M216F, I43V-Y89A-M117A-M216L, I43V-Y89A-M117F- M216A, I43V-Y89A-M117F-M216F, I43V-Y89A-M117F-M216L, I43V-Y89A-M117I-M216A, I43V- Y89A-M117I-M216F, I43V-Y89A-M117I-M216L, I43V-Y89A-M117L-M216A, I43V-Y89A-M117L- M216F, I43V-Y89A-M117L-M216L, I43V-Y89A-M117V-M216A, I43V-Y89A-M117V-M216F, I43V- Y89A-M117V-M216L, I43V-M117A, I43V-M117F, I43V-M1171, I43V-M117L, I43V-M117V, I43V- M117A-M216A, I43V-M117A-M216F, I43V-M117A-M216L, I43V-M117F-M216A, I43V-M117F-M216F, I43V-M117F-M216L, I43V-M117I-M216A, I43V-M117I-M216F, I43V-M117I-M216L, I43V-M117L- M216A, I43V-M117L-M216F, I43V-M117L-M216L, I43V-M117V-M216A, I43V-M117V-M216F, I43V- M117V-M216L, I43V-M216A, I43V-M216F, I43V-M216L,M122L-N154S-T156A-A29G, M122L-N154S- T156A-A29G-D58P, M122L-N154S-T156A-A29G-Y89A, M122L-N154S-T156A-A29G-M117A, M122L- N154S-T156A-A29G-M117F, M122L-N154S-T156A-A29G-M117I, M122L-N154S-T156A-A29G- M117L, M122L-N154S-T156A-A29G-M117V, M122L-N154S-T156A-A29G-M216A, M122L-N154S- T156A-A29G-M216F, M122L-N154S-T156A-A29G-M216L, M122L-N154S-T156A-A29G-D58P-Y89A, M122L-N154S-T156A-A29G-D58P-M117A, M122L-N154S-T156A-A29G-D58P-M117F, M122L- N154S-T156A-A29G-D58P-M117I, M122L-N154S-T156A-A29G-D58P-M117L, M122L-N154S-T156A- A29G-D58P-M117V, M122L-N154S-T156A-A29G-D58P-M216A, M122L-N154S-T156A-A29G-D58P- M216F, M122L-N154S-T156A-A29G-D58P-M216L, M122L-N154S-T156A-A29G-Y89A-M117A, M122L-N154S-T156A-A29G-Y89A-M117F, M122L-N154S-T156A-A29G-Y89A-M117I, M122L-N154S- T156A-A29G-Y89A-M117L, M122L-N154S-T156A-A29G-Y89A-M117V, M122L-N154S-T156A-A29G- Y89A-M216A, M122L-N154S-T156A-A29G-Y89A-M216F, M122L-N154S-T156A-A29G-Y89A-M216L, M122L-N154S-T156A-A29G-M117A-M216A, M122L-N154S-T156A-A29G-M117A-M216F,M122L- N154S-T156A-A29G-M117A-M216L, M122L-N154S-T156A-A29G-D58P-Y89A-M117A, M122L- N154S-T156A-A29G-D58P-Y89A-M117F, M122L-N154S-T156A-A29G-D58P-Y89A-M117I, M122L- N154S-T156A-A29G-D58P-Y89A-M117L, M122L-N154S-T156A-A29G-D58P-Y89A-M117V, M122L- N154S-T156A-A29G-D58P-Y89A-M216A, M122L-N154S-T156A-A29G-D58P-Y89A-M216F, M122L- N154S-T156A-A29G-D58P-Y89A-M216L, M122L-N154S-T156A-A29G-Y89A-M117A-M216A, M122L- N154S-T156A-A29G-Y89A-M117A-M216F, M122L-N154S-T156A-A29G-Y89A-M117A-M216L, M122L-N154S-T156A-A29G-Y89A-M117F-M216A, M122L-N154S-T156A-A29G-Y89A-M117F- M216F, M122L-N154S-T156A-A29G-Y89A-M117F-M216L, M122L-N154S-T156A-A29G-Y89A-M117I- M216A, M122L-N154S-T156A-A29G-Y89A-M117I-M216F, M122L-N154S-T156A-A29G-Y89A-M117I- M216L, M122L-N154S-T156A-A29G-Y89A-M117L-M216A, M122L-N154S-T156A-A29G-Y89A- M117L-M216F, M122L-N154S-T156A-A29G-Y89A-M117L-M216L, M122L-N154S-T156A-A29G- Y89A-M117V-M216A, M122L-N154S-T156A-A29G-Y89A-M117V-M216F, M122L-N154S-T156A- A29G-Y89A-M117V-M216L,M122L-N154S-T156A-D58P, M122L-N154S-T156A-D58P-Y89A, M122L- N154S-T156A-D58P-M117A, M122L-N154S-T156A-D58P-M117F, M122L-N154S-T156A-D58P- M117I, M122L-N154S-T156A-D58P-M117L, M122L-N154S-T156A-D58P-M117V, M122L-N154S- T156A-D58P-M216A, M122L-N154S-T156A-D58P-M216F, M122L-N154S-T156A-D58P-M216L, M122L-N154S-T156A-D58P-Y89A-M117A, M122L-N154S-T156A-D58P-Y89A-M117F, M122L-,

[0081] N154S-T156A-D58P-Y89A-M117I, M122L-N154S-T156A-D58P-Y89A-M117L, M122L-N154S-T156A- D58P-Y89A-M117V, M122L-N154S-T156A-D58P-Y89A-M216A, M122L-N154S-T156A-D58P-Y89A- M216F, M122L-N154S-T156A-D58P-Y89A-M216L, M122L-N154S-T156A-D58P-M117A-M216A, M122L-N154S-T156A-D58P-M117A-M216F, M122L-N154S-T156A-D58P-M117A-M216L, M122L- N154S-T156A-D58P-M117F-M216A, M122L-N154S-T156A-D58P-M117F-M216F, M122L-N154S- T156A-D58P-M117F-M216L, M122L-N154S-T156A-D58P-M117I-M216A, M122L-N154S-T156A- D58P-M117I-M216F, M122L-N154S-T156A-D58P-M117I-M216L, M122L-N154S-T156A-D58P- M117L-M216A, M122L-N154S-T156A-D58P-M117L-M216F, M122L-N154S-T156A-D58P-M117L- M216L, M122L-N154S-T156A-D58P-M117V-M216A, M122L-N154S-T156A-D58P-M117V-M216F, M122L-N154S-T156A-D58P-M117V-M216L, M122L-N154S-T156A-Y89A, M122L-N154S-T156A- Y89A-M117A, M122L-N154S-T156A-Y89A-M117F, M122L-N154S-T156A-Y89A-M1171, M122L- N154S-T156A-Y89A-M117L, M122L-N154S-T156A-Y89A-M117V, M122L-N154S-T156A-Y89A- M216A, M122L-N154S-T156A-Y89A-M216F,M122L-N154S-T156A-Y89A-M216L, M122L-N154S- T156A-Y89A-M117A-M216A, M122L-N154S-T156A-Y89A-M117A-M216F, M122L-N154S-T156A- Y89A-M117A-M216L, M122L-N154S-T156A-Y89A-M117F-M216A, M122L-N 154S-T156A-Y89A- M117F-M216F, M122L-N154S-T156A-Y89A-M117F-M216L, M122L-N154S-T156A-Y89A-M117I- M216A, M122L-N154S-T156A-Y89A-M117I-M216F, M122L-N154S-T156A-Y89A-M117I-M216L, M122L-N154S-T156A-Y89A-M117L-M216A, M122L-N154S-T156A-Y89A-M117L-M216F, M122L- N 154S-T156A-Y89A-M 117L-M216L, M 122L-N 154S-T156A-Y89A-M 117V-M216A, M 122L-N 154S- T156A-Y89A-M117V-M216F, M122L-N154S-T156A-Y89A-M117V-M216L, M122L-N154S-T156A- M117A, M122L-N154S-T156A-M117F, M122L-N154S-T156A-M1171, M122L-N154S-T156A-M117L, M122L-N154S-T156A-M117V, M122L-N154S-T156A-M117A-M216A, M122L-N154S-T156A-M117A- M216F, M122L-N154S-T156A-M117A-M216L, M122L-N154S-T156A-M117F-M216A, M122L-N154S- T156A-M117F-M216F, M122L-N154S-T156A-M117F-M216L, M122L-N154S-T156A-M117I-M216A, M122L-N154S-T156A-M117I-M216F, M122L-N154S-T156A-M117I-M216L,M122L-N154S-T156A- M117L-M216A, M122L-N154S-T156A-M117L-M216F, M122L-N154S-T156A-M117L-M216L, M122L- N154S-T156A-M117V-M216A, M122L-N154S-T156A-M117V-M216F, M122L-N154S-T156A-M117V- M216L, M122L-N154S-T156A-M216A, M122L-N154S-T156A-M216F, M122L-N154S-T156A-M216L, M211 N-P212D-A29G, M211 N-P212D-A29G-D58P, M211 N-P212D-A29G-Y89A, M211 N-P212D- A29G-M117A, M211 N-P212D-A29G-M117F, M211 N-P212D-A29G-M117I, M211 N-P212D-A29G- M117L, M211 N-P212D-A29G-M117V, M211 N-P212D-A29G-M216A, M211 N-P212D-A29G-M216F, M211 N-P212D-A29G-M216L, M211 N-P212D-A29G-D58P-Y89A, M211 N-P212D-A29G-D58P-M117A, M211 N-P212D-A29G-D58P-M117F, M211 N-P212D-A29G-D58P-M117I, M211 N-P212D-A29G-D58P- M117L, M211 N-P212D-A29G-D58P-M117V, M211 N-P212D-A29G-D58P-M216A, M211 N-P212D- A29G-D58P-M216F, M211 N-P212D-A29G-D58P-M216L, M211 N-P212D-A29G-Y89A-M117A, M211 N-P212D-A29G-Y89A-M117F, M211 N-P212D-A29G-Y89A-M1171, M211 N-P212D-A29G-Y89A- M117L, M211 N-P212D-A29G-Y89A-M117V, M211 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N-P212D-Y89A,<h2 style=";text-align:left;direction:ltr">M211 N-P212D-Y89A-M117A, M211 N-P212D-Y89A-M117F, M211 N-P212D-Y89A-M1171, M211 N-P212D-Y89A-M117L, M211 N-P212D-Y89A-M117V, M211 N-P212D-Y89A-M216A, M211 N-P212D-Y89A-M216F, M211 N-P212D-Y89A-M216L, M211 N-P212D-Y89A-M117A-M216A, M211 N-P212D-Y89A-M117A-M216F, M211 N-P212D-Y89A-M117A-M216L, M211 N-P212D-Y89A-M117F-M216A, M211 N-P212D-Y89A-M117F-M216F, M211 N-P212D-Y89A-M117I-M216A, M211 N-P212D-Y89A-M117I-M216F, M211 N-P212D-Y89A-M117I-M216L, M211 N-P212D-Y89A-M117I-M216L, M211 N-P212D-Y89A-M117I-M216A, M211 N-P212D-Y89A-M117L-M216F, M211 N-P212D-Y89A-M117L-M216L, M211 N- P212D-Y89A-M117V-M216A, M211 N-P212D-Y89A-M117V- M216L, M211 N-P212D-M117A, M211 N-P212D-M117F, M211 N-P212D-M117I, M211 N-P212D- M117L, M211 N-P212D-M117V, M211 N-P212D-M117A-M216A, M211 N-P212D-M117A-M216F, M211 N-P212D-M117A-M216L, M211 N-P212D-M117F-M216A, M211 N-P212D-M117F-M216F, M211 N-P212D-M117F-M216L, M211 N-P212D-M117I-M216A, M211 N-P212D-M117I-M216F,M211 N- P212D-M117I-M216L, M211 N-P212D-M117L-M216A, M211 N-P212D-M117L-M216F, M211 N-P212D- M117L-M216L, M211 N-P212D-M117V-M216A, M211 N-P212D-M117V-M216F, M211 N-P212D- M117V-M216L, M211 N-P212D-M216A, M211 N-P212D-M216F, M211 N-P212D-M216L, M211 L- P212D-A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L- P212D-A29G-M117V, M211 L-P212D-A29G-M216A, M211 L-P212D-A29G-M216F, M211 L-P212D- A29G-M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P-M117A, M211 L-P212D- A29G-D58P-M117F, M211 L-P212D-A29G-D58P-M117I, M211 L-P212D-A29G-D58P-M117L, M211 L- P212D-A29G-D58P-M117V, M211 L-P212D-A29G-D58P-M216A, M211 L-P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P-M216L, M211 L-P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A- M117F, M211 L-P212D-A29G-Y89A-M117I, M211 L-P212D-A29G-Y89A-M117L, M211 L-P212D-A29G- Y89A-M117V, M211 L-P212D-A29G-Y89A-M216A, M211 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P212H-D58P-M117V-M216A,P212H-D58P-M117V-M216F, P212H-D58P-M117V- M216L, P212H-Y89A, P212H-Y89A-M117A, P212H-Y89A-M117F, P212H-Y89A-M1171, P212H- Y89A-M117L, P212H-Y89A-M117V, P212H-Y89A-M216A, P212H-Y89A-M216F, P212H-Y89A- M216L, P212H-Y89A-M117A-M216A, P212H-Y89A-M117A-M216F, P212H-Y89A-M117A-M216L, P212H-Y89A-M117F-M216A, P212H-Y89A-M117F-M216F, P212H-Y89A-M117F-M216L, P212H- Y89A-M117I-M216A, P212H-Y89A-M117I-M216F, P212H-Y89A-M117I-M216L, P212H-Y89A-M117L- M216A, P212H-Y89A-M117L-M216F, P212H-Y89A-M117L-M216L, P212H-Y89A-M117V-M216A, P212H-Y89A-M117V-M216F, P212H-Y89A-M117V-M216L, P212H-M117A, P212H-M117F, P212H- M117I, P212H-M117L, P212H-M117V, P212H-M117A-M216A, P212H-M117A-M216F, P212H- M117A-M216L, P212H-M117F-M216A, P212H-M117F-M216F, P212H-M117F-M216L, P212H-M117I- M216A, P212H-M117I-M216F, P212H-M117I-M216L, P212H-M117L-M216A, P212H-M117L-M216F, P212H-M117L-M216L, P212H-M117V-M216A, P212H-M117V-M216F, P212H-M117V-M216L, P212H-M216A, P212H-M216F, P212H-M216L, Q12L-M122L-A222S-A29G,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-D58P, Q12L-M122L-A222S-A29G-Y89A, Q12L-M122L-A222S-A29G-M117A, Q12L-M122L- A222S-A29G-M117F, Q12L-M122L-A222S-A29G-M1171, Q12L-M122L-A222S-A29G-M117L, Q12L-M122L-A222S-A29G-M117V, Q12L-M122L-A222S-A29G-M216A, Q12L-M122L-A222S-A29G-M216F, Q12L-M122L-A222S-A29G-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A, Q12L-M122L-A222S-A29G-D58P-M117A, Q12L-M122L-A222S-A29G-D58P-M117F, Q12L-M122L-A222S-A29G-D58P-M117I, Q12L-M122L-A222S-A29G-D58P-M117L, Q12L-M122L-A222S-A29G-D58P-M117V, Q12L- M122L-A222S-A29G-D58P-M216A, Q12L-M122L-A222S-A29G-D58P-M216F, Q12L-M122L-A222S- A29G-D58P-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A, Q12L-M122L-A222S-A29G-Y89A-M117F, Q12L-M122L-A222S-A29G-Y89A-M117I, Q12L-M122L-A222S-A29G-Y89A-M117L, Q12L- M122L-A222S-A29G-Y89A-M117V, Q12L-M122L-A222S-A29G-Y89A-M216A, Q12L-M122L-A222S-A29G-Y89A-M216F, Q12L-M122L-A222S-A29G-Y89A-M216L, Q12L-M122L-A222S-A29G-M117A-M216A, Q12L-M122L-A222S-A29G-M117A-M216F, Q12L-M122L-A222S-A29G-M117A-M216L,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-D58P-Y89A-M117A, Q12L-M122L-A222S-A29G-D58P-Y89A-M117F, Q12L-M122L-A222S-A29G-D58P-Y89A-M117I, Q12L-M122L-A222S-A29G-D58P-Y89A-M117L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117V, Q12L-M122L-A222S-A29G-D58P-Y89A-M216A, Q12L-M122L-A222S-A29G-D58P-Y89A-M216F, Q12L-M122L-A222S-A29G-D58P-Y89A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A-M216A, Q12L-M122L-A222S-A29G-Y89A-M117A-M216F, Q12L-M122L-A222S-A29G-Y89A-M117A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A-M216A, Q12L-M122L-A222S-A29G-Y89A-M117F-M216F, Q12L-M122L-A222S-A29G-Y89A-M117F-M216L, Q12L-M122L-A222S-A29G-Y89A-M117I-M216A, Q12L-M122L-A222S-A29G-Y89A-M117I-M216F, Q12L-M122L-A222S-A29G-Y89A-M117I-M216L, Q12L-M122L-A222S-A29G-Y89A-M117L-M216A, Q12L-M122L-A222S-A29G-Y89A-M117L-M216F, Q12L-M122L-A222S-A29G-Y89A-M117L-M216L, Q12L-M122L-A222S-A29G-Y89A-M117V-M216A, Q12L-M122L-A222S-A29G-Y89A-M117V-M216F, Q12L-M122L-A222S-A29G-Y89A-M117V-M216L, Q12L-M122L-A222S-D58P, Q12L-M122L-A222S-D58P-Y89A, Q12L-M122L-A222S-D58P-M117A,Q12L-M122L-A222S-D58P-M117F, Q12L-M122L- A222S-D58P-M1171, Q12L-M122L-A222S-D58P-M117L, Q12L-M122L-A222S-D58P-M117V, Q12L- M122L-A222S-D58P-M216A, Q12L-M122L-A222S-D58P-M216F, Q12L-M122L-A222S-D58P-M216L, Q12L-M122L-A222S-D58P-Y89A-M117A, Q12L-M122L-A222S-D58P-Y89A-M117F, Q12L-M122L- A222S-D58P-Y89A-M1171, Q12L-M122L-A222S-D58P-Y89A-M117L, Q12L-M122L-A222S-D58P- Y89A-M117V, Q12L-M122L-A222S-D58P-Y89A-M216A, Q12L-M122L-A222S-D58P-Y89A-M216F, Q12L-M122L-A222S-D58P-Y89A-M216L, Q12L-M122L-A222S-D58P-M117A-M216A, Q12L-M122L- A222S-D58P-M117A-M216F, Q12L-M122L-A222S-D58P-M117A-M216L, Q12L-M122L-A222S-D58P- M117F-M216A, Q12L-M122L-A222S-D58P-M117F-M216F, Q12L-M122L-A222S-D58P-M117F- M216L, Q12L-M122L-A222S-D58P-M117I-M216A, Q12L-M122L-A222S-D58P-M117I-M216F, Q12L- M122L-A222S-D58P-M117I-M216L, Q12L-M122L-A222S-D58P-M117L-M216A, Q12L-M122L-A222S- D58P-M117L-M216F, Q12L-M122L-A222S-D58P-M117L-M216L, Q12L-M122L-A222S-D58P-M117V- M216A, Q12L-M122L-A222S-D58P-M117V-M216F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-D58P-M117V-M216L, Q12L-M122L-A222S-Y89A, Q12L-M122L-A222S-Y89A-M117A, Q12L-M122L-A222S-Y89A-M117F, Q12L-M122L-A222S-Y89A-M1171, Q12L-M122L-A222S-Y89A-M117L, Q12L-M122L-A222S-Y89A-M117V, Q12L-M122L-A222S-Y89A-M216A, Q12L-M122L-A222S-Y89A-M216F, Q12L-M122L-A222S-Y89A-M216L, Q12L-M122L-A222S-Y89A-M117A-M216A, Q12L-M122L-A222S-Y89A-M117A-M216F, Q12L-M122L-A222S-Y89A-M117A-M216L, Q12L-M122L-A222S-Y89A-M117F-M216A, Q12L-M122L-A222S-Y89A-M117F-M216F, Q12L-M122L-A222S-Y89A-M117F-M216L, Q12L-M122L-A222S-Y89A-M117I-M216A, Q12L-M122L-A222S-Y89A-M117I-M216F, Q12L-M122L-A222S-Y89A-M117I-M216L, Q12L-M122L-A222S-Y89A-M117L-M216A, Q12L-M122L-A222S-Y89A-M117L-M216F, Q12L-M122L-A222S-Y89A-M117L-M216L, Q12L-M122L-A222S-Y89A-M117V-M216A, Q12L-M122L-A222S-Y89A-M117V-M216F, Q12L-M122L-A222S-Y89A-M117V-M216L, Q12L-M122L-A222S-M117A, Q12L- M122L-A222S-M117F, Q12L-M122L-A222S-M1171, Q12L-M122L-A222S-M117L, Q12L-M122L-A222S-M117V, Q12L-M122L-A222S-M117A-M216A,Q12L-M122L-A222S-M117A-M216F, Q12L-M122L-A222S-M117A-M216L, Q12L-M122L-A222S-M117F-M216A, Q12L-M122L-A222S-M117F-M216F, Q12L-M122L-A222S-M117F-M216L, Q12L-M122L-A222S-M117I-M216A, Q12L-M122L-A222S-M117I-M216F, Q12L-M122L-A222S-M117I-M216L, Q12L-M122L-A222S-M117L-M216A, Q12L-M122L-A222S-M117L-M216F, Q12L-M122L-A222S-M117L-M216L, Q12L-M122L-A222S- M117V-M216A, Q12L-M122L-A222S-M117V-M216F, Q12L-M122L-A222S-M117V-M216L, Q12L- M122L-A222S-M216A, Q12L-M122L-A222S-M216F, Q12L-M122L-A222S-M216L existing group selected wherein the numbering is based in each case on the numbering according to SEQ ID NO:1, wherein the protease comprises no further changes besides the amino acid substitutions mentioned, and wherein the protease has improved stability in washing or cleaning agents, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing agents, particularly preferably automatic dishwashing agents containing bleach,the stability being determined as described in Example 3.,

[0082] In preferred embodiments, the protease of the invention comprises an M211 L-P212D- A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211A L-P212D-A29G-M117A, M211 L- P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L-P212D-M-M117G-M1172 L-P212D-A29G-M216A, M211 L-P212D-A29G-M216F, M211 L-P212D-A29G- M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P-M117A, M211 L-P212D-A29G- D58P-M117F, M211 L-P212D-A29G-D58P-M117I, M211 L-P212D-A29G-D-M117L, M217L L-P212D- A29G-D58P-M117V, M211 L-P212D-A29G-D58P-M216A, M211 L-P212D-A29G-D58P-M216F, M211 L- P212D-A29G-M-D216L, M216L L-P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D-A29G-Y89A-M117I, M211 L-P212D-A29G-M-Y117L, M217L L-P212D-A29G-Y89A- M117V, M211 L-P212D-A29G-Y89A-M216A, M211 L-P212D-A29G-Y89A-M216F, M211 L-P212D- A29G-M-Y216L, M216L L-P212D-A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F, M211 L-P212D-A29G-M117A-M216L, M211 L-P212D-A29A-M217A-YM211 L-P212D- A29G-D58P-Y89A-M117F, M211 L-P212D-A29G-D58P-Y89A-M117I, M211 L-P212D-A29G-D58P- Y89A-M117L, M211 L-P212D-A29G-D58P-Y89A-M117V, M211 L-P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P-Y89A-M216F, M211 L-P212D-A29G-D58P-Y89A-M216L, M211 L-P212D- A29G-Y89A-M117A-M216A, M211 L-P212D-A29G-Y89A-M117A-M216F, M211 L-P212D-A29G-Y89A- M117A-M216L, M211 L-P212D-A29G-Y89A-M117F-M216A, M211 L-P212D-A29G-Y89A-M117F- M216F, M211 L-P212D-A29G-Y89A-M117F-M216L, M211 L-P212D-A29G-Y89A-M117I-M216A, M211 L-P212D-A29G-Y89A-M117I-M216F, M211 L-P212D-A29G-Y89A-M117I-M216L, M211 L-P212D- A29G-Y89A-M117L-M216A, M211 L-P212D-A29G-Y89A-M117L-M216F, M211 L-P212D-A29G-Y89A- M117L-M216L, M211 L-P212D-A29G-Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V- M216F, M211 L-P212D-A29G-Y89A-M117V-M216L, M211 L-P212D-D58P, M211 L-P212D-D58P- Y89A, M211 L-P212D-D58P-M117A, M211 L-P212D-D58P-M117F, M211 L-P212D-D58P-M117I, M211 L-P212D-D58P-M117L, M211 L-P212D-D58P-M117V, M211 L-P212D-D58P-M216A,M211 L- P212D-D58P-M216F, M211 L-P212D-D58P-M216L, M211 L-P212D-D58P-Y89A-M117A, M211 L- P212D-D58P-Y89A-M117F, M211 L-P212D-D58P-Y89A-M117I, M211 L-P212D-D58P-Y89A-M117L, M211 L-P212D-D58P-Y89A-M117V, M211 L-P212D-D58P-Y89A-M216A, M211 L-P212D-D58P-Y89A- M216F, M211 L-P212D-D58P-Y89A-M216L, M211 L-P212D-D58P-M117A-M216A, M211 L-P212D- D58P-M117A-M216F, M211 L-P212D-D58P-M117A-M216L, M211 L-P212D-D58P-M117F-M216A, M211 L-P212D-D58P-M117F-M216F, M211 L-P212D-D58P-M117F-M216L, M211 L-P212D-D58P- M117I-M216A, M211 L-P212D-D58P-M117I-M216F, M211 L-P212D-D58P-M117I-M216L, M211 L- P212D-D58P-M117L-M216A, M211 L-P212D-D58P-M117L-M216F, M211 L-P212D-D58P-M117L- M216L, M211 L-P212D-D58P-M117V-M216A, M211 L-P212D-D58P-M117V-M216F, M211 L-P212D- D58P-M117V-M216L, M211 L-P212D-Y89A, M211 L-P212D-Y89A-M117A, M211 L-P212D-Y89A- M117F, M211 L-P212D-Y89A-M1171, M211 L-P212D-Y89A-M117L, M211 L-P212D-Y89A-M117V, M211 L-P212D-Y89A-M216A, M211 L-P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L,M211 L- P212D-Y89A-M117A-M216A, M211 L-P212D-Y89A-M117A-M216F, M211 L-P212D-Y89A-M117A- M216L, M211 L-P212D-Y89A-M117F-M216A, M211 L-P212D-Y89A-M117F-M216F, M211 L-P212D- Y89A-M117F-M216L, M211 L-P212D-Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A-M117L-M216A, M211 L-P212D-Y89A- M117L-M216F, M211 L-P212D-Y89A-M117L-M216L, M211 L-P212D-Y89A-M117V-M216A, M211 L- P212D-Y89A-M117V-M216F, M211 L-P212D-Y89A-M117V-M216L, M211 L-P212D-M117A, M211 L- P212D-M117F, M211 L-P212D-M1171, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D- M117A-M216A, M211 L-P212D-M117A-M216F, M211 L-P212D-M117A-M216L, M211 L-P212D-M117F- M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L-P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L- P212D-M117L-M216F, M211 L-P212D-M117L-M216L, M211 L-P212D-M117V-M216A, M211 L-P212D- M117V-M216F, M211 L-P212D-M117V-M216L, M211 L-P212D-M216A,M211 L-P212D-M216F, M211 L-P212D-M216L, wherein the numbering is based in each case on the numbering according to SEQ ID NO:1, wherein the protease comprises no further changes besides the amino acid substitutions mentioned, and wherein the protease has improved stability in washing or cleaning agents, in particular bleach-containing washing and cleaning agents, preferably automatic dishwashing agents, particularly preferably bleach-containing automatic dishwashing agents, wherein the stability is determined as described in Example 3.

[0083] In preferred embodiments, the protease according to the invention comprises an amino acid substitution combination selected from the group consisting of M117A-M211 L-P212D, Y89A-M117A-M211 L-P212D, M117V-M211 L-P212D, A29G-M117V-M211 L-P212D, M117F-M211 L-P212D, M117I-M211 L-P212D, M117L-M211 L-P212D, M211 L-P212D-M216F, D58P-M211 L-P212D-M216A and M211 L-P212D-M216L, wherein the numbering is in each case based on the numbering according to SEQ ID NO:1, wherein the Protease comprises no further changes besides the amino acid substitutions mentioned, and wherein the protease has improved stability in washing or cleaning agents, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing agents, particularly preferably automatic dishwashing agents containing bleach, wherein the stability is determined as described in Example 3.

[0084] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, wherein the stability is determined as described in Example 3.

[0085] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216,at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, wherein the stability is determined as described in Example 3.

[0086] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 211 and 212, at least one amino acid substitution selected from the group consisting of M211 N, M211 L, P212D and P212H, preferably M211 L and / or P212D, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution,which is selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, the stability being determined as described in Example 3.

[0087] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, two amino acid substitutions selected from the group consisting of M211N, M211L, P212D and P212H, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, the stability being determined as described in Example 3.

[0088] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at the positions corresponding to positions 211 and 212, the amino acid substitutions M211L and P212D, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L,wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, the stability being determined as described in Example 3.,

[0089] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, (i) an amino acid substitution or amino acid substitution combination selected from the group consisting of I43V, M122L-N154S-T156A, M211 N-P212D, M211 L-P212D, G160S, D127P-M211 L-P212D, P212H and Q12L-M122L-A222S, and (ii) an amino acid substitution or amino acid substitution combination selected from the group consisting of A29G, A29G-D58P, A29G-Y89A, A29G-M117A, A29G-M117F, A29G-M1171, A29G- M117L, A29G-M117V,<h2 style=";text-align:left;direction:ltr">A29G-M216A, A29G-M216F, A29G-M216L, A29G-D58P-Y89A, A29G-D58P- M117A, A29G-D58P-M117F, A29G-D58P-M1171, A29G-D58P-M117L, A29G-D58P-M117V, A29G- D58P-M216A, A29G-D58P-M216F, A29G-D58P-M216L, A29G-Y89A-M117A, A29G-Y89A-M117F, A29G-Y89A-M1171, A29G-Y89A-M117L, A29G-Y89A-M117V, A29G-Y89A-M216A, A29G-Y89A-M216F, A29G-Y89A-M216L, A29G-M117A-M216A, A29G-M117A-M216F, A29G-M117A-M216L, A29G-D58P-Y89A-M117A, A29G-D58P-Y89A-M117F, A29G-D58P-Y89A-M1171, A29G-D58P-Y89A-M117L, A29G-D58P-Y89A-M117V, A29G-D58P-Y89A-M216A, A29G-D58P-Y89A-M216F, A29G- D58P-Y89A-M216L, A29G-Y89A-M117A-M216A, A29G-Y89A-M117A-M216F, A29G-Y89A-M117A-M216L, A29G-Y89A-M117F-M216A, A29G-Y89A-M117F-M216F, A29G-Y89A-M117F-M216L, A29G-Y89A-M117I-M216A, A29G-Y89A-M117I-M216F, A29G-Y89A-M117I-M216L, A29G-Y89A-M117L- M216A, A29G-Y89A-M117L-M216F, A29G-Y89A-M117L-M216L, A29G-Y89A-M117V-M216A, A29G-Y89A-M117V-M216F, A29G-Y89A-M117V-M216L, D58P, D58P-Y89A, D58P-M117A, D58P-M117F, D58P-M1171, D58P-M117L, D58P-M117V, D58P-M216A,D58P-M216F, D58P-M216L, D58P-Y89A- M117A, D58P-Y89A-M117F, D58P-Y89A-M1171, D58P-Y89A-M117L, D58P-Y89A-M117V, D58P- Y89A-M216A, D58P-Y89A-M216F, D58P-Y89A-M216L, D58P-M117A-M216A, D58P-M117A-M216F, D58P-M117A-M216L, D58P-M117F-M216A, D58P-M117F-M216F, D58P-M117F-M216L, D58P- M117I-M216A, D58P-M117I-M216F, D58P-M117I-M216L, D58P-M117L-M216A, D58P-M117L- M216F, D58P-M117L-M216L, D58P-M117V-M216A, D58P-M117V-M216F, D58P-M117V-M216L, Y89A, Y89A-M117A, Y89A-M117F, Y89A-M1171, Y89A-M117L, Y89A-M117V, Y89A-M216A, Y89A- M216F, Y89A-M216L, Y89A-M117A-M216A, Y89A-M117A-M216F, Y89A-M117A-M216L, Y89A- M117F-M216A, Y89A-M117F-M216F, Y89A-M117F-M216L, Y89A-M117I-M216A, Y89A-M117I- M216F, Y89A-M117I-M216L, Y89A-M117L-M216A, Y89A-M117L-M216F, Y89A-M117L-M216L, Y89A-M117V-M216A, Y89A-M117V-M216F, Y89A-M117V-M216L, M117A, M117F, M117I, M117L, M117V, M117A-M216A, M117A-M216F, M117A-M216L, M117F-M216A, M117F-M216F, M117F- M216L, M117I-M216A, M117I-M216F, M117I-M216L, M117L-M216A, M117L-M216F, M117L-M216L,M117V-M216A, M117V-M216F, M117V-M216L, M216A, M216F, M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, the stability being determined as described in Example 3.

[0090] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, (i) an amino acid substitution or amino acid substitution combination selected from the group consisting of I43V, M122L-N154S-T156A, M211 N-P212D, M211 L-P212D, G160S, D127P-M211 L-P212D, P212H and Q12L-M122L-A222S, and (ii) an amino acid substitution orAn amino acid substitution combination selected from the group consisting of M117A, M117A-Y89L, M117V, M117V-A29G, M117F, M117I, M117L, M216F, D58P-M216A, M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, wherein the stability is determined as described in Example 3.

[0091] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which is selected from the group consisting of I43V-A29G, I43V-A29G-D58P, I43V-A29G-Y89A, I43V-A29G-M117A, I43V-A29G-M117F, I43V-A29G-M117I, I43V-A29G-M117L, I43V-A29G-M117V, I43V-A29G-M216A, I43V-A29G-M216F, I43V-A29G-M216L, I43V-A29G-D58P-Y89A, I43V-A29G-D58P-M117A, I43V-A29G-D58P-M117F, I43V-A29G-D58P-M117I, I43V-A29G-D58P-M117L, I43V-A29G-D58P-M117V, I43V-A29G-D58P-M216A, I43V-A29G-D58P-M216F,I43V-A29G-D58P-M216L, I43V-A29G-Y89A-M117A, I43V-A29G- Y89A-M117F, I43V-A29G-Y89A-M1171, I43V-A29G-Y89A-M117L, I43V-A29G-Y89A-M117V, I43V- A29G-Y89A-M216A, I43V-A29G-Y89A-M216F, I43V-A29G-Y89A-M216L, I43V-A29G-M117A-M216A, I43V-A29G-M117A-M216F, I43V-A29G-M117A-M216L, I43V-A29G-D58P-Y89A-M117A, I43V-A29G- D58P-Y89A-M117F, I43V-A29G-D58P-Y89A-M1171, I43V-A29G-D58P-Y89A-M117L, I43V-A29G- D58P-Y89A-M117V, I43V-A29G-D58P-Y89A-M216A, I43V-A29G-D58P-Y89A-M216F, I43V-A29G- D58P-Y89A-M216L, I43V-A29G-Y89A-M117A-M216A, I43V-A29G-Y89A-M117A-M216F, I43V-A29G- Y89A-M117A-M216L, I43V-A29G-Y89A-M117F-M216A, I43V-A29G-Y89A-M117F-M216F, I43V- A29G-Y89A-M117F-M216L, I43V-A29G-Y89A-M117I-M216A, I43V-A29G-Y89A-M117I-M216F, I43V- A29G-Y89A-M117I-M216L, I43V-A29G-Y89A-M117L-M216A, I43V-A29G-Y89A-M117L-M216F, I43V- A29G-Y89A-M117L-M216L, I43V-A29G-Y89A-M117V-M216A, I43V-A29G-Y89A-M117V-M216F, I43V-A29G-Y89A-M117V-M216L, I43V-D58P, I43V-D58P-Y89A, I43V-D58P-M117A, I43V-D58P- M117F, I43V-D58P-M1171,I43V-D58P-M117L, I43V-D58P-M117V, I43V-D58P-M216A, I43V-D58P- M216F, I43V-D58P-M216L, I43V-D58P-Y89A-M117A, I43V-D58P-Y89A-M117F, I43V-D58P-Y89A- M117I, I43V-D58P-Y89A-M117L, I43V-D58P-Y89A-M117V, I43V-D58P-Y89A-M216A, I43V-D58P- Y89A-M216F, I43V-D58P-Y89A-M216L, I43V-D58P-M117A-M216A, I43V-D58P-M117A-M216F, I43V- D58P-M117A-M216L, I43V-D58P-M117F-M216A, I43V-D58P-M117F-M216F, I43V-D58P-M117F- M216L, I43V-D58P-M117I-M216A, I43V-D58P-M117I-M216F, I43V-D58P-M117I-M216L, I43V-D58P- M117L-M216A, I43V-D58P-M117L-M216F, I43V-D58P-M117L-M216L, I43V-D58P-M117V-M216A, I43V-D58P-M117V-M216F, I43V-D58P-M117V-M216L, I43V-Y89A, I43V-Y89A-M117A, I43V-Y89A- M117F, I43V-Y89A-M1171, I43V-Y89A-M117L, I43V-Y89A-M117V, I43V-Y89A-M216A, I43V-Y89A- M216F, I43V-Y89A-M216L, I43V-Y89A-M117A-M216A, I43V-Y89A-M117A-M216F, I43V-Y89A- M117A-M216L, I43V-Y89A-M117F-M216A, I43V-Y89A-M117F-M216F, I43V-Y89A-M117F-M216L, I43V-Y89A-M117I-M216A, I43V-Y89A-M117I-M216F, I43V-Y89A-M117I-M216L, I43V-Y89A-M117L- M216A,I43V-Y89A-M117L-M216F, I43V-Y89A-M117L-M216L, I43V-Y89A-M117V-M216A, I43V- Y89A-M117V-M216F, I43V-Y89A-M117V-M216L, I43V-M117A, I43V-M117F, I43V-M1171, I43V- M117L, I43V-M117V, I43V-M117A-M216A, I43V-M117A-M216F, I43V-M117A-M216L, I43V-M117F- M216A, I43V-M117F-M216F, I43V-M117F-M216L, I43V-M117I-M216A, I43V-M117I-M216F, I43V- M117I-M216L, I43V-M117L-M216A, I43V-M117L-M216F, I43V-M117L-M216L, I43V-M117V-M216A, I43V-M117V-M216F, I43V-M117V-M216L, I43V-M216A, I43V-M216F, I43V-M216L, M122L-N154S- T156A-A29G, M122L-N154S-T156A-A29G-D58P, M122L-N154S-T156A-A29G-Y89A, M122L-N154S- T156A-A29G-M117A, M122L-N154S-T156A-A29G-M117F, M122L-N154S-T156A-A29G-M1171, M122L-N154S-T156A-A29G-M117L, M122L-N154S-T156A-A29G-M117V, M122L-N154S-T156A- A29G-M216A, M122L-N154S-T156A-A29G-M216F, M122L-N154S-T156A-A29G-M216L, M122L- N154S-T156A-A29G-D58P-Y89A, M122L-N154S-T156A-A29G-D58P-M117A, M122L-N154S-T156A- A29G-D58P-M117F, M122L-N154S-T156A-A29G-D58P-M117I, M122L-N154S-T156A-A29G-D58P- M117L,M122L-N154S-T156A-A29G-D58P-M117V, M122L-N154S-T156A-A29G-D58P-M216A, M122L-N154S-T156A-A29G-D58P-M216F, M122L-N154S-T156A-A29G-D58P-M216L, M122L- N154S-T156A-A29G-Y89A-M117A, M122L-N154S-T156A-A29G-Y89A-M117F, M122L-N154S- T156A-A29G-Y89A-M117I, M122L-N154S-T156A-A29G-Y89A-M117L, M122L-N154S-T156A-A29G- Y89A-M117V, M122L-N154S-T156A-A29G-Y89A-M216A, M122L-N154S-T156A-A29G-Y89A-M216F, M122L-N154S-T156A-A29G-Y89A-M216L, M122L-N154S-T156A-A29G-M117A-M216A, M122L- N154S-T156A-A29G-M117A-M216F, M122L-N154S-T156A-A29G-M117A-M216L, M122L-N154S- T156A-A29G-D58P-Y89A-M117A, M122L-N154S-T156A-A29G-D58P-Y89A-M117F, M122L-N154S- T156A-A29G-D58P-Y89A-M1171, M122L-N154S-T156A-A29G-D58P-Y89A-M117L, M122L-N154S- T156A-A29G-D58P-Y89A-M117V, M122L-N154S-T156A-A29G-D58P-Y89A-M216A, M122L-N154S- T156A-A29G-D58P-Y89A-M216F, M122L-N154S-T156A-A29G-D58P-Y89A-M216L, M122L-N154S- T156A-A29G-Y89A-M117A-M216A, M122L-N154S-T156A-A29G-Y89A-M117A-M216F, M122L- N154S-T156A-A29G-Y89A-M117A-M216L,M122L-N154S-T156A-A29G-Y89A-M117F-M216A, M122L-N154S-T156A-A29G-Y89A-M117F-M216F, M122L-N154S-T156A-A29G-Y89A-M117F- M216L, M122L-N154S-T156A-A29G-Y89A-M117I-M216A, M122L-N154S-T156A-A29G-Y89A-M1171- M216F, M122L-N154S-T156A-A29G-Y89A-M117I-M216L, M122L-N154S-T156A-A29G-Y89A-M117L- M216A, M122L-N154S-T156A-A29G-Y89A-M117L-M216F, M122L-N154S-T156A-A29G-Y89A- M117L-M216L, M122L-N154S-T156A-A29G-Y89A-M117V-M216A, M122L-N154S-T156A-A29G- Y89A-M117V-M216F, M122L-N154S-T156A-A29G-Y89A-M117V-M216L, M122L-N154S-T156A- D58P, M122L-N154S-T156A-D58P-Y89A, M122L-N154S-T156A-D58P-M117A, M122L-N154S- T156A-D58P-M117F, M122L-N154S-T156A-D58P-M1171, M122L-N154S-T156A-D58P-M117L, M122L-N154S-T156A-D58P-M117V, M122L-N154S-T156A-D58P-M216A, M122L-N154S-T156A- D58P-M216F, M122L-N154S-T156A-D58P-M216L, M122L-N154S-T156A-D58P-Y89A-M117A, M122L-N154S-T156A-D58P-Y89A-M117F, M122L-N154S-T156A-D58P-Y89A-M117I, M122L-N154S- T156A-D58P-Y89A-M117L, M122L-N154S-T156A-D58P-Y89A-M117V,M122L-N154S-T156A-D58P- Y89A-M216A, M122L-N154S-T156A-D58P-Y89A-M216F, M122L-N154S-T156A-D58P-Y89A-M216L, M122L-N154S-T156A-D58P-M117A-M216A, M122L-N154S-T156A-D58P-M117A-M216F, M122L- N154S-T156A-D58P-M117A-M216L, M122L-N154S-T156A-D58P-M117F-M216A, M122L-N154S- T156A-D58P-M117F-M216F, M122L-N154S-T156A-D58P-M117F-M216L, M122L-N154S-T156A- D58P-M117I-M216A, M122L-N154S-T156A-D58P-M117I-M216F, M122L-N154S-T156A-D58P- M117I-M216L, M122L-N154S-T156A-D58P-M117L-M216A, M122L-N154S-T156A-D58P-M117L- M216F, M122L-N154S-T156A-D58P-M117L-M216L, M122L-N154S-T156A-D58P-M117V-M216A, M122L-N154S-T156A-D58P-M117V-M216F, M122L-N154S-T156A-D58P-M117V-M216L, M122L- N154S-T156A-Y89A, M122L-N154S-T156A-Y89A-M117A, M122L-N154S-T156A-Y89A-M117F, M122L-N154S-T156A-Y89A-M117I, M122L-N154S-T156A-Y89A-M117L, M122L-N154S-T156A- Y89A-M117V, M122L-N154S-T156A-Y89A-M216A, M122L-N154S-T156A-Y89A-M216F, M122L- N154S-T156A-Y89A-M216L, M122L-N154S-T156A-Y89A-M117A-M216A, 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N-P212D-A29G-M117A-M216A,M211 N-P212D-A29G-M117A-M216F, M211 N-P212D- A29G-M117A-M216L, M211 N-P212D-A29G-D58P-Y89A-M117A, M211 N-P212D-A29G-D58P-Y89A- M117F, M211 N-P212D-A29G-D58P-Y89A-M117I, M211 N-P212D-A29G-D58P-Y89A-M117L, M211 N- P212D-A29G-D58P-Y89A-M117V, M211 N-P212D-A29G-D58P-Y89A-M216A, M211 N-P212D-A29G- D58P-Y89A-M216F, M211 N-P212D-A29G-D58P-Y89A-M216L, M211 N-P212D-A29G-Y89A-M117A- M216A, M211 N-P212D-A29G-Y89A-M117A-M216F, M211 N-P212D-A29G-Y89A-M117A-M216L, M211 N-P212D-A29G-Y89A-M117F-M216A, M211 N-P212D-A29G-Y89A-M117F-M216F, M211 N- P212D-A29G-Y89A-M117F-M216L, M211 N-P212D-A29G-Y89A-M117I-M216A, M211 N-P212D-A29— Y89A-M117I-M216F, M211 N-P212D-A29G-Y89A-M117I-M216L, M211 N-P212D-A29G-Y89A-M117L- M216A, M211 N-P212D-A29G-Y89A-M117L-M216F, M211 N-P212D-A29G-Y89A-M117L-M216L, M211 N-P212D-A29G-Y89A-M117V-M216A, M211 N-P212D-A29G-Y89A-M117V-M216F, M211 N- P212D-A29— Y89A-M117V-M216L, M211 N-P212D-D58P, M211 N-P212D-D58P-Y89A, M211 N- P212D-D58P-M117A, M211 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N-P212D-Y89A-M117L,<h2 style=";text-align:left;direction:ltr">M211 N-P212D-Y89A-M117V, M211 N-P212D-Y89A-M216A, M211 N-P212D-Y89A-M216F, M211 N-P212D-Y89A-M216L, M211 N-P212D-Y89A-M117A-M216A, M211 N-P212D-Y89A-M117A-M216F, M211 N-P212D-Y89A-M117A-M216L, M211 N-P212D-Y89A-M117F-M216A, M211 N-P212D-Y89A-M117F-M216F, M211 N-P212D-Y89A-M117F-M216L, M211 N-P212D-Y89A-M117I-M216A, M211 N-P212D-Y89A-M117I-M216F, M211 N-P212D-Y89A-M117I-M216L, M211 N-P212D-Y89A-M117L-M216A, M211 N-P212D-Y89A-M117L-M216F, M211 N-P212D-Y89A-M117L-M216L, M211 N-P212D-Y89A-M117V-M216A, M211 N-P212D- M211 N-P212D-M117I M211 N-P212D- N-P212D-M117L, M211 N-P212D-M117V, M211 N-P212D- M117A-M216A, M211 N-P212D-M117A-M216F, M117F-M216A, M211 N-P212D-M117F-M216F, M211 N-P212D-M117F-M216L, M211 N-P212D-M1171- M216A, M211 N-P212D-M117I-M216F, M21 1 N-P212D-M117I-M216L, M211 N-P212D-M117L-M216A, M211 N-P212D-M1 17L-M216F, M211 N-P212D-M117L-M216L,M211 N-P212D-M117V-M216A, M211 N-P212D-M1 17V-M216F, M21 1 N-P212D-M117V-M216L, M21 1 N-P212D-M216A, M211 N- P212D-M216F, M21 1 N-P212D-M216L, M21 1 L-P212D-A29G, M211 L-P212D-A29G-D58P, M211 L- P212D-A29G-Y89A, M21 1 L-P212D-A29G-M117A, M211 L-P212D-A29G-M1 17F, M211 L-P212D- A29G-M117I, M211 L-P212D-A29G-M117L, M21 1 L-P212D-A29G-M117V, M211 L-P212D-A29G- M216A, M211 L-P212D-A29G-M216F, M211 L-P212D-A29G-M216L, M211 L-P212D-A29G-D58P- Y89A, M211 L-P212D-A29G-D58P-M117A, M211 L-P212D-A29G-D58P-M117F, M211 L-P212D-A29G- D58P-M1171, M21 1 L-P212D-A29G-D58P-M117L, M211 L-P212D-A29G-D58P-M117V, M211 L-P212D- A29G-D58P-M216A, M211 L-P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P-M216L, M211 L- P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D-A29G-Y89A-M1171, M211 L-P212D-A29G-Y89A-M117L, M21 1 L-P212D-A29G-Y89A-M117V, M211 L-P212D-A29G-Y89A- M216A, M211 L-P212D-A29G-Y89A-M216F, M211 L-P212D-A29G-Y89A-M216L, M211 L-P212D- A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F,M211 L-P212D-A29G-M117A-M216L, M21 1 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L-P212D-Y89A-M216L, M211 L-P212D-Y89A-M117A-M216A, M211 L- P212D-Y89A-M117A-M216F, M21 1 L-P212D-Y89A-M1 17A-M216L, M211 L-P212D-Y89A-M117F- M216A, M211 L-P212D-Y89A-M117F-M216F, M211 L-P212D-Y89A-M117F-M216L, M211 L-P212D- Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A-M117L-M216A, M211 L-P212D-Y89A-M117L-M216F, M211 L-P212D-Y89A- M117L-M216L, M211 L-P212D-Y89A-M117V-M216A, M211 L-P212D-Y89A-M117V-M216F, M211 L- P212D-Y89A-M117V-M216L, M211 L-P212D-M117A, M211 L-P212D-M117F, M211 L-P212D-M117I, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L-P212D-M117A- M216F, M211 L-P212D-M117A-M216L, M211 L-P212D-M117F-M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L- P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L-P212D-M117L-M216F, M211 L-P212D- M117L-M216L, M211 L-P212D-M117V-M216A,M211 L-P212D-M117V-M216F, M211 L-P212D-M117V- M216L, M211 L-P212D-M216A, M211 L-P212D-M216F, M211 L-P212D-M216L, G160S-A29G, G160S- A29G-D58P, G160S-A29G-Y89A, G160S-A29G-M117A, G160S-A29G-M117F, G160S-A29G-M1171, G160S-A29G-M117L, G160S-A29G-M117V, G160S-A29G-M216A, G160S-A29G-M216F, G160S-A29G-M216L, G160S-A29G-D58P-Y89A, G160S-A29G-D58P-M117A, G160S-A29G-D58P-M117F, G160S-A29G-D58P-M1171, G160S-A29G-D58P-M117L, G160S-A29G-D58P-M117V, G160S-A29G-D58P-M216A, G160S-A29G-D58P-M216F, G160S-A29G-D58P-M216L, G160S-A29G-Y89A-M117A, G160S-A29G-Y89A-M117F, G160S-A29G-Y89A-M1171, G160S-A29G-Y89A-M117L, G160S-A29G-Y89A-M117V, G160S-A29G-Y89A-M216A, G160S-A29G-Y89A-M216F, G160S-A29G-Y89A-M216L, G160S-A29G-M117A-M216A, G160S-A29G-M117A-M216F, G160S-A29G-M117A-M216L, G160S-A29G-D58P-Y89A-M117A, G160S-A29G-D58P-Y89A-M117F, G160S-A29G-D58P-Y89A-M117I, G160S-A29G-D58P-Y89A-M117L, G160S-A29G-D58P-Y89A-M117V, G160S-A29G-D58P-Y89A-M216A, G160S-A29G-D58P-Y89A-M216F, G160S-A29G-D58P-Y89A-M216L,G160S-A29G-Y89A- M117A-M216A, G160S-A29G-Y89A-M117A-M216F, G160S-A29G-Y89A-M117A-M216L, G160S- A29G-Y89A-M117F-M216A, G160S-A29G-Y89A-M117F-M216F, G160S-A29G-Y89A-M117F-M216L, G160S-A29G-Y89A-M117I-M216A, G160S-A29G-Y89A-M117I-M216F, G160S-A29G-Y89A-M1171- M216L, G160S-A29G-Y89A-M117L-M216A, G160S-A29G-Y89A-M117L-M216F, G160S-A29G-Y89A- M117L-M216L, G160S-A29G-Y89A-M117V-M216A, G160S-A29G-Y89A-M117V-M216F, G160S- A29G-Y89A-M117V-M216L, G160S-D58P, G160S-D58P-Y89A, G160S-D58P-M117A, G160S-D58P- M117F, G160S-D58P-M1171, G160S-D58P-M117L, G160S-D58P-M117V, G160S-D58P-M216A, G160S-D58P-M216F, G160S-D58P-M216L, G160S-D58P-Y89A-M117A, G160S-D58P-Y89A-M117F, G160S-D58P-Y89A-M1171, G160S-D58P-Y89A-M117L, G160S-D58P-Y89A-M117V, G160S-D58P- Y89A-M216A, G160S-D58P-Y89A-M216F, G160S-D58P-Y89A-M216L, G160S-D58P-M117A-M216A, G160S-D58P-M117A-M216F, G160S-D58P-M117A-M216L, G160S-D58P-M117F-M216A, G160S- D58P-M117F-M216F, G160S-D58P-M117F-M216L, G160S-D58P-M117I-M216A, G160S-D58P- M117I-M216F,G160S-D58P-M117I-M216L, G160S-D58P-M117L-M216A, G160S-D58P-M117L- M216F, G160S-D58P-M117L-M216L, G160S-D58P-M117V-M216A, G160S-D58P-M117V-M216F, G160S-D58P-M117V-M216L, G160S-Y89A, G160S-Y89A-M117A, G160S-Y89A-M117F, G160S- Y89A-M117I, G160S-Y89A-M117L, G160S-Y89A-M117V, G160S-Y89A-M216A, G160S-Y89A- M216F, G160S-Y89A-M216L, G160S-Y89A-M117A-M216A, G160S-Y89A-M117A-M216F, G160S- Y89A-M117A-M216L, G160S-Y89A-M117F-M216A, G160S-Y89A-M117F-M216F, G160S-Y89A- M117F-M216L, G160S-Y89A-M117I-M216A, G160S-Y89A-M117I-M216F, G160S-Y89A-M1171- M216L, G160S-Y89A-M117L-M216A, G160S-Y89A-M117L-M216F, G160S-Y89A-M117L-M216L, G160S-Y89A-M117V-M216A, G160S-Y89A-M117V-M216F, G160S-Y89A-M117V-M216L, G160S- M117A, G160S-M117F, G160S-M1171, G160S-M117L, G160S-M117V, G160S-M117A-M216A, G160S-M117A-M216F, G160S-M117A-M216L, G160S-M117F-M216A, G160S-M117F-M216F, G160S-M117F-M216L, G160S-M117I-M216A, G160S-M117I-M216F, G160S-M117I-M216L, G160S- M117L-M216A, G160S-M117L-M216F, G160S-M117L-M216L,G160S-M117V-M216A, G160S- M117V-M216F, G160S-M117V-M216L, G160S-M216A, G160S-M216F, G160S-M216L, D127P- M211 L-P212D-A29G, D127P-M211 L-P212D-A29G-D58P, D127P-M211 L-P212D-A29G-Y89A, D127P-M211 L-P212D-A29G-M117A, D127P-M211 L-P212D-A29G-M117F, D127P-M211 L-P212D- A29G-M117I, D127P-M211 L-P212D-A29G-M117L, D127P-M211 L-P212D-A29G-M117V, D127P- M211 L-P212D-A29G-M216A, D127P-M211 L-P212D-A29G-M216F, D127P-M211 L-P212D-A29G- M216L, D127P-M211 L-P212D-A29G-D58P-Y89A, D127P-M211 L-P212D-A29G-D58P-M117A, D127P-M211 L-P212D-A29G-D58P-M117F, D127P-M211 L-P212D-A29G-D58P-M1171, D127P- M211 L-P212D-A29G-D58P-M117L, D127P-M211 L-P212D-A29G-D58P-M117V, D127P-M211 L- P212D-A29G-D58P-M216A, D127P-M211 L-P212D-A29G-D58P-M216F, D127P-M211 L-P212D- A29G-D58P-M216L, D127P-M211 L-P212D-A29G-Y89A-M117A, D127P-M211 L-P212D-A29G-Y89A- M117F, D127P-M211 L-P212D-A29G-Y89A-M1171, D127P-M211 L-P212D-A29G-Y89A-M117L, D127P-M211 L-P212D-A29G-Y89A-M117V, D127P-M211 L-P212D-A29G-Y89A-M216A,D127P- M211 L-P212D-A29G-Y89A-M216F, D127P-M211 L-P212D-A29G-Y89A-M216L, D127P-M211 L- P212D-A29G-M117A-M216A, D127P-M211 L-P212D-A29G-M117A-M216F, D127P-M211 L-P212D- A29G-M117A-M216L, D127P-M211 L-P212D-A29G-D58P-Y89A-M117A, D127P-M211 L-P212D- A29G-D58P-Y89A-M117F, D127P-M211 L-P212D-A29G-D58P-Y89A-M1171, D127P-M211 L-P212D- A29G-D58P-Y89A-M117L, D127P-M211 L-P212D-A29G-D58P-Y89A-M117V, D127P-M211 L-P212D- A29G-D58P-Y89A-M216A, D127P-M211 L-P212D-A29G-D58P-Y89A-M216F, D127P-M211 L-P212D- A29G-D58P-Y89A-M216L, D127P-M211 L-P212D-A29G-Y89A-M117A-M216A, D127P-M211 L- P212D-A29G-Y89A-M117A-M216F, D127P-M211 L-P212D-A29G-Y89A-M117A-M216L, D127P- M211 L-P212D-A29G-Y89A-M117F-M216A, D127P-M211 L-P212D-A29G-Y89A-M117F-M216F, D127P-M211 L-P212D-A29G-Y89A-M117F-M216L, D127P-M211 L-P212D-A29G-Y89A-M117I-M216A, D127P-M211 L-P212D-A29— Y89A-M117I-M216F, D127P-M211 L-P212D-A29G-Y89A-M117I-M216L, D127P-M211 L-P212D-A29G-Y89A-M117L-M216A, D127P-M211 L-P212D-A29G-Y89A-M117L- M216F,D127P-M211 L-P212D-A29G-Y89A-M117L-M216L, D127P-M211 L-P212D-A29G-Y89A- M117V-M216A, D127P-M211 L-P212D-A29G-Y89A-M117V-M216F, D127P-M211 L-P212D-A29G- Y89A-M117V-M216L, D127P-M211 L-P212D-D58P, D127P-M211 L-P212D-D58P-Y89A, D127P- M211 L-P212D-D58P-M117A, D127P-M211 L-P212D-D58P-M117F, D127P-M211 L-P212D-D58P- M117I, D127P-M211 L-P212D-D58P-M117L, D127P-M211 L-P212D-D58P-M117V, D127P-M211 L- P212D-D58P-M216A, D127P-M211 L-P212D-D58P-M216F, D127P-M211 L-P212D-D58P-M216L, D127P-M211 L-P212D-D58P-Y89A-M117A, D127P-M211 L-P212D-D58P-Y89A-M117F, D127P-,

[0092] M211 L-P212D-D58P-Y89A-M1171, D127P-M211 L-P212D-D58P-Y89A-M117L, D127P-M211 L-P212D- D58P-Y89A-M117V, D127P-M211 L-P212D-D58P-Y89A-M216A, D127P-M211 L-P212D-D58P-Y89A- M216F, D127P-M211 L-P212D-D58P-Y89A-M216L, D127P-M211 L-P212D-D58P-M117A-M216A, D127P-M211 L-P212D-D58P-M117A-M216F, D127P-M211 L-P212D-D58P-M117A-M216L, D127P- M211 L-P212D-D58P-M117F-M216A, D127P-M211 L-P212D-D58P-M117F-M216F, D127P-M211 L- P212D-D58P-M117F-M216L, D127P-M211 L-P212D-D58P-M117I-M216A, D127P-M211 L-P212D- D58P-M117I-M216F, D127P-M211 L-P212D-D58P-M117I-M216L, D127P-M211 L-P212D-D58P- M117L-M216A, D127P-M211 L-P212D-D58P-M117L-M216F, D127P-M211 L-P212D-D58P-M117L- M216L, D127P-M211 L-P212D-D58P-M117V-M216A, D127P-M211 L-P212D-D58P-M117V-M216F, D127P-M211 L-P212D-D58P-M117V-M216L, D127P-M211 L-P212D-Y89A, D127P-M211 L-P212D- Y89A-M117A, D127P-M211 L-P212D-Y89A-M117F, D127P-M211 L-P212D-Y89A-M1171, D127P- M211 L-P212D-Y89A-M117L, D127P-M211 L-P212D-Y89A-M117V, D127P-M211 L-P212D-Y89A- M216A,D127P-M211 L-P212D-Y89A-M216F, D127P-M211 L-P212D-Y89A-M216L, D127P-M211 L- P212D-Y89A-M117A-M216A, D127P-M211 L-P212D-Y89A-M117A-M216F, D127P-M211 L-P212D- Y89A-M117A-M216L, D127P-M211 L-P212D-Y89A-M117F-M216A, D127P-M211 L-P212D-Y89A- M117F-M216F, D127P-M211 L-P212D-Y89A-M117F-M216L, D127P-M211 L-P212D-Y89A-M1171- M216A, D127P-M211 L-P212D-Y89A-M117I-M216F, D127P-M211 L-P212D-Y89A-M117I-M216L, D127P-M211 L-P212D-Y89A-M117L-M216A, D127P-M211 L-P212D-Y89A-M117L-M216F, D127P- M211 L-P212D-Y89A-M117L-M216L, D127P-M211 L-P212D-Y89A-M117V-M216A, D127P-M211 L- P212D-Y89A-M117V-M216F, D127P-M211 L-P212D-Y89A-M117V-M216L, D127P-M211 L-P212D- M117A, D127P-M211 L-P212D-M117F, D127P-M211 L-P212D-M1171, D127P-M211 L-P212D-M117L, D127P-M211 L-P212D-M117V, D127P-M211 L-P212D-M117A-M216A, D127P-M211 L-P212D-M117A- M216F, D127P-M211 L-P212D-M117A-M216L, D127P-M211 L-P212D-M117F-M216A, D127P-M211 L- P212D-M117F-M216F, D127P-M211 L-P212D-M117F-M216L, D127P-M211 L-P212D-M117I-M216A,D127P-M211 L-P212D-M117I-M216F, D127P-M211 L-P212D-M117I-M216L, D127P-M211 L-P212D- M117L-M216A, D127P-M211 L-P212D-M117L-M216F, D127P-M211 L-P212D-M117L-M216L, D127P- M211 L-P212D-M117V-M216A, D127P-M211 L-P212D-M117V-M216F, D127P-M211 L-P212D-M117V- M216L, D127P-M211 L-P212D-M216A, D127P-M211 L-P212D-M216F, D127P-M211 L-P212D-M216L, P212H-A29G, P212H-A29G-D58P, P212H-A29G-Y89A, P212H-A29G-M117A, P212H-A29G-M117F, P212H-A29G-M1171, P212H-A29G-M117L, P212H-A29G-M117V, P212H-A29G-M216A, P212H- A29G-M216F, P212H-A29G-M216L, P212H-A29G-D58P-Y89A, P212H-A29G-D58P-M117A, P212H- A29G-D58P-M117F, P212H-A29G-D58P-M1171, P212H-A29G-D58P-M117L, P212H-A29G-D58P- M117V, P212H-A29G-D58P-M216A, P212H-A29G-D58P-M216F, P212H-A29G-D58P-M216L, P212H-A29G-Y89A-M117A, P212H-A29G-Y89A-M117F, P212H-A29G-Y89A-M1171, P212H-A29G- Y89A-M117L, P212H-A29G-Y89A-M117V, P212H-A29G-Y89A-M216A, P212H-A29G-Y89A-M216F, P212H-A29G-Y89A-M216L, P212H-A29G-M117A-M216A, P212H-A29G-M117A-M216F, P212H- A29G-M117A-M216L,P212H-A29G-D58P-Y89A-M117A, P212H-A29G-D58P-Y89A-M117F, P212H- A29G-D58P-Y89A-M1171, P212H-A29G-D58P-Y89A-M117L, P212H-A29G-D58P-Y89A-M117V, P212H-A29G-D58P-Y89A-M216A, P212H-A29G-D58P-Y89A-M216F, P212H-A29G-D58P-Y89A- M216L, P212H-A29G-Y89A-M117A-M216A, P212H-A29G-Y89A-M117A-M216F, P212H-A29G-Y89A- M117A-M216L, P212H-A29G-Y89A-M117F-M216A, P212H-A29G-Y89A-M117F-M216F, P212H- A29G-Y89A-M117F-M216L, P212H-A29G-Y89A-M117I-M216A, P212H-A29G-Y89A-M117I-M216F, P212H-A29G-Y89A-M117I-M216L, P212H-A29G-Y89A-M117L-M216A, P212H-A29G-Y89A-M117L- M216F, P212H-A29G-Y89A-M117L-M216L, P212H-A29G-Y89A-M117V-M216A, P212H-A29G-Y89A- M117V-M216F, P212H-A29G-Y89A-M117V-M216L, P212H-D58P, P212H-D58P-Y89A, P212H-D58P- M117A, P212H-D58P-M117F, P212H-D58P-M1171, P212H-D58P-M117L, P212H-D58P-M117V, P212H-D58P-M216A, P212H-D58P-M216F, P212H-D58P-M216L, P212H-D58P-Y89A-M117A, P212H-D58P-Y89A-M117F, P212H-D58P-Y89A-M1171, P212H-D58P-Y89A-M117L, P212H-D58P- Y89A-M117V, P212H-D58P-Y89A-M216A, P212H-D58P-Y89A-M216F,P212H-D58P-Y89A-M216L, P212H-D58P-M117A-M216A, P212H-D58P-M117A-M216F, P212H-D58P-M117A-M216L, P212H- D58P-M117F-M216A, P212H-D58P-M117F-M216F, P212H-D58P-M117F-M216L, P212H-D58P- M117I-M216A, P212H-D58P-M117I-M216F, P212H-D58P-M117I-M216L, P212H-D58P-M117L- M216A, P212H-D58P-M117L-M216F, P212H-D58P-M117L-M216L, P212H-D58P-M117V-M216A, P212H-D58P-M117V-M216F, P212H-D58P-M117V-M216L, P212H-Y89A, P212H-Y89A-M117A, P212H-Y89A-M117F, P212H-Y89A-M1171, P212H-Y89A-M117L, P212H-Y89A-M117V, P212H-Y89A- M216A, P212H-Y89A-M216F, P212H-Y89A-M216L, P212H-Y89A-M117A-M216A, P212H-Y89A- M117A-M216F, P212H-Y89A-M117A-M216L, P212H-Y89A-M117F-M216A, P212H-Y89A-M117F- M216F, P212H-Y89A-M117F-M216L, P212H-Y89A-M117I-M216A, P212H-Y89A-M117I-M216F, P212H-Y89A-M117I-M216L, P212H-Y89A-M117L-M216A, P212H-Y89A-M117L-M216F, P212H- Y89A-M117L-M216L, P212H-Y89A-M117V-M216A, P212H-Y89A-M117V-M216F, P212H-Y89A- M117V-M216L, P212H-M117A, P212H-M117F, P212H-M117I, P212H-M117L, P212H-M117V, P212H-M117A-M216A,<h2 style=";text-align:left;direction:ltr">P212H-M117A-M216F, P212H-M117A-M216L, P212H-M117F-M216A, P212H-M117F-M216F, P212H-M117F-M216L, P212H-M117I-M216A, P212H-M117I-M216F, P212H- M117I-M216L, P212H-M117L-M216A, P212H-M117L-M216F, P212H-M117L-M216L, P212H-M117V- M216A, P212H-M117V-M216F, P212H-M117V-M216L, P212H-M216A, P212H-M216F, P212H-M216L, Q12L-M122L-A222S-A29G, Q12L-M122L-A222S-A29G-D58P, Q12L-M122L-A222S-A29G-Y89A, Q12L-M122L-A222S-A29G-M117A, Q12L-M122L-A222S-A29G-M117F, Q12L-M122L-A222S-A29G-M117I, Q12L-M122L-A222S-A29G-M117L, Q12L-M122L-A222S-A29G-M117V, Q12L-M122L- A222S-A29G-M216A, Q12L-M122L-A222S-A29G-M216F, Q12L-M122L-A222S-A29G-M216L, Q12L- M122L-A222S-A29G-D58P-Y89A, Q12L-M122L-A222S-A29G-D58P-M117A, Q12L-M122L-A222S- A29G-D58P-M117F, Q12L-M122L-A222S-A29G-D58P-M117I, Q12L-M122L-A222S-A29G-D58P-M117L, Q12L-M122L-A222S-A29G-D58P-M117V, Q12L-M122L-A222S-A29G-D58P-M216A, Q12L- M122L-A222S-A29G-D58P-M216F, Q12L-M122L-A222S-A29G-D58P-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A, Q12L-M122L-A222S-A29G-Y89A-M117F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117I, Q12L-M122L-A222S-A29G-Y89A-M117L, Q12L-M122L-A222S-A29G-Y89A-M117V, Q12L- M122L-A222S-A29G-Y89A-M216A, Q12L-M122L-A222S-A29G-Y89A-M216F, Q12L-M122L-A222S-A29G-Y89A-M216L, Q12L-M122L-A222S-A29G-M117A-M216A, Q12L-M122L-A222S-A29G-M117A-M216F, Q12L-M122L-A222S-A29G-M117A-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117A, Q12L-M122L-A222S-A29G-D58P-Y89A-M117F, Q12L-M122L-A222S-A29G-D58P-Y89A-M1171, Q12L-M122L-A222S-A29G-D58P-Y89A-M117L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117V, Q12L-M122L-A222S-A29G-D58P-Y89A-M216A, Q12L-M122L-A222S-A29G-D58P-Y89A-M216F, Q12L-M122L-A222S-A29G-D58P-Y89A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A-M216A, Q12L-M122L-A222S-A29G-Y89A-M117A-M216F, Q12L-M122L-A222S-A29G-Y89A-M117A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117F-M216A, Q12L-M122L-A222S-A29G-Y89A-M117F-M216F, Q12L-M122L-A222S-A29G-Y89A-M117F-M216L, Q12L-M122L-A222S-A29G-Y89A-M117I-M216A, Q12L-M122L-A222S-A29G-Y89A-M117I-M216F, Q12L-M122L-A222S-A29G-Y89A-M117I-M216L,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117L-M216A, Q12L-M122L-A222S-A29G-Y89A-M117L-M216F, Q12L-M122L-A222S-A29G-Y89A-M117L-M216L, Q12L-M122L-A222S-A29G-Y89A-M117V-M216A, Q12L-M122L-A222S-A29G-Y89A-M117V-M216F, Q12L-M122L-A222S-A29G-Y89A-M117V-M216L, Q12L-M122L-A222S-D58P, Q12L-M122L-A222S-D58P-Y89A, Q12L-M122L-A222S-D58P-M117A, Q12L-M122L-A222S-D58P-M117F, Q12L-M122L-A222S-D58P-M1171, Q12L-M122L-A222S-D58P- M117L, Q12L-M122L-A222S-D58P-M117V, Q12L-M122L-A222S-D58P-M216A, Q12L-M122L-A222S- D58P-M216F, Q12L-M122L-A222S-D58P-M216L, Q12L-M122L-A222S-D58P-Y89A-M117A, Q12L- M122L-A222S-D58P-Y89A-M117F, Q12L-M122L-A222S-D58P-Y89A-M1171, Q12L-M122L-A222S- D58P-Y89A-M117L, Q12L-M122L-A222S-D58P-Y89A-M117V, Q12L-M122L-A222S-D58P-Y89A-M216A, Q12L-M122L-A222S-D58P-Y89A-M216F, Q12L-M122L-A222S-D58P-Y89A-M216L, Q12L- M122L-A222S-D58P-M117A-M216A, Q12L-M122L-A222S-D58P-M117A-M216F, Q12L-M122L- A222S-D58P-M117A-M216L, Q12L-M122L-A222S-D58P-M117F-M216A, Q12L-M122L-A222S-D58P- M117F-M216F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-D58P-M117F-M216L, Q12L-M122L-A222S-D58P-M1171- M216A, Q12L-M122L-A222S-D58P-M117I-M216F, Q12L-M122L-A222S-D58P-M117I-M216L, Q12L- M122L-A222S-D58P-M117L-M216A, Q12L-M122L-A222S-D58P-M117L-M216F, Q12L-M122L- A222S-D58P-M117L-M216L, Q12L-M122L-A222S-D58P-M117V-M216A, Q12L-M122L-A222S-D58P-M117V-M216F, Q12L-M122L-A222S-D58P-M117V-M216L, Q12L-M122L-A222S-Y89A, Q12L-M122L-A222S-Y89A-M117A, Q12L-M122L-A222S-Y89A-M117F, Q12L-M122L-A222S-Y89A-M1171, Q12L-M122L-A222S-Y89A-M117L, Q12L-M122L-A222S-Y89A-M117V, Q12L-M122L-A222S-Y89A-M216A, Q12L-M122L-A222S-Y89A-M216F, Q12L-M122L-A222S-Y89A-M216L, Q12L-M122L-A222S-Y89A-M117A-M216A, Q12L-M122L-A222S-Y89A-M117A-M216F, Q12L-M122L-A222S-Y89A-M117A-M216L, Q12L-M122L-A222S-Y89A-M117F-M216A, Q12L-M122L-A222S-Y89A-M117F-M216F, Q12L- M122L-A222S-Y89A-M117F-M216L, Q12L-M122L-A222S-Y89A-M117I-M216A, Q12L-M122L-A222S-Y89A-M117I-M216F, Q12L-M122L-A222S-Y89A-M117I-M216L, Q12L-M122L-A222S-Y89A-M117L-M216A, Q12L-M122L-A222S-Y89A-M117L-M216F,Q12L-M122L-A222S-Y89A-M117L-M216L, Q12L- M122L-A222S-Y89A-M117V-M216A, Q12L-M122L-A222S-Y89A-M117V-M216F, Q12L-M122L- A222S-Y89A-M117V-M216L, Q12L-M122L-A222S-M117A, Q12L-M122L-A222S-M117F, Q12L-M122L-A222S-M1171, Q12L-M122L-A222S-M117L, Q12L-M122L-A222S-M117V, Q12L-M122L-A222S-M117A-M216A, Q12L-M122L-A222S-M117A-M216F, Q12L-M122L-A222S-M117A-M216L, Q12L-M122L-A222S-M117F-M216A, Q12L-M122L-A222S-M117F-M216F, Q12L-M122L-A222S-M117F-M216L, Q12L-M122L-A222S-M117I-M216A, Q12L-M122L-A222S-M117I-M216F, Q12L-M122L-A222S-M117I-M216L, Q12L-M122L-A222S-M117L-M216A, Q12L-M122L-A222S-M117L-M216F, Q12L-M122L-A222S-M117L-M216L, Q12L-M122L-A222S-M117V-M216A, Q12L-M122L-A222S-M117V-M216F, Q12L-M122L-A222S-M117V-M216L, Q12L-M122L-A222S-M216A, Q12L-M122L-A222S-M216F, Q12L-M122L-A222S-M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents,the stability being determined as described in Example 3.,

[0093] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which consists of the one selected from M211 L-P212D-A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L-P212D-A29G-M117V, M211 L-P212D-A29G-M216A, M211 L-P212D-A29G- M216F, M211 L-P212D-A29G-M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P- M117A,M211 L-P212D-A29G-D58P-M117F, M211 L-P212D-A29G-D58P-M117I, M211 L-P212D- A29G-D58P-M117L, M211 L-P212D-A29G-D58P-M117V, M211 L-P212D-A29G-D58P-M216A, M211 L- P212D-A29G-D58P-M216F, M211 L-P212D-A29G-D58P-M216L, M211 L-P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D-A29G-Y89A-M117I, M211 L-P212D-A29G-Y89A- M117L, M211 L-P212D-A29G-Y89A-M117V, M211 L-P212D-A29G-Y89A-M216A, M211 L-P212D- A29G-Y89A-M216F, M211 L-P212D-A29G-Y89A-M216L, M211 L-P212D-A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F, M211 L-P212D-A29G-M117A-M216L, M211 L-P212D-A29G- D58P-Y89A-M117A, M211 L-P212D-A29G-D58P-Y89A-M117F, M211 L-P212D-A29G-D58P-Y89A- M117I, M211 L-P212D-A29G-D58P-Y89A-M117L, M211 L-P212D-A29G-D58P-Y89A-M117V, M211 L- P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P-Y89A-M216F, M211 L-P212D-A29G- D58P-Y89A-M216L, M211 L-P212D-A29G-Y89A-M117A-M216A, M211 L-P212D-A29G-Y89A-M117A- M216F, M211 L-P212D-A29G-Y89A-M117A-M216L, M211 L-P212D-A29G-Y89A-M117F-M216A,M211 L-P212D-A29G-Y89A-M117F-M216F, M211 L-P212D-A29G-Y89A-M117F-M216L, M211 L- P212D-A29G-Y89A-M117I-M216A, M211 L-P212D-A29G-Y89A-M117I-M216F, M211 L-P212D-A29G- Y89A-M117I-M216L, M211 L-P212D-A29G-Y89A-M117L-M216A, M211 L-P212D-A29G-Y89A-M117L- M216F, M211 L-P212D-A29G-Y89A-M117L-M216L, M211 L-P212D-A29G-Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V-M216F, M211 L-P212D-A29G-Y89A-M117V-M216L, M211 L- P212D-D58P, M211 L-P212D-D58P-Y89A, M211 L-P212D-D58P-M117A, M211 L-P212D-D58P- M117F, M211 L-P212D-D58P-M117I, M211 L-P212D-D58P-M117L, M211 L-P212D-D58P-M117V, M211 L-P212D-D58P-M216A, M211 L-P212D-D58P-M216F, M211 L-P212D-D58P-M216L, M211 L- P212D-D58P-Y89A-M117A, M211 L-P212D-D58P-Y89A-M117F, M211 L-P212D-D58P-Y89A-M1171, M211 L-P212D-D58P-Y89A-M117L, M211 L-P212D-D58P-Y89A-M117V, M211 L-P212D-D58P-Y89A- M216A, M211 L-P212D-D58P-Y89A-M216F, M211 L-P212D-D58P-Y89A-M216L, M211 L-P212D- D58P-M117A-M216A, M211 L-P212D-D58P-M117A-M216F, M211 L-P212D-D58P-M117A-M216L,M211 L-P212D-D58P-M117F-M216A, M211 L-P212D-D58P-M117F-M216F, M211 L-P212D-D58P- M117F-M216L, M211 L-P212D-D58P-M117I-M216A, M211 L-P212D-D58P-M117I-M216F, M211 L- P212D-D58P-M117I-M216L, M211 L-P212D-D58P-M117L-M216A, M211 L-P212D-D58P-M117L- M216F, M211 L-P212D-D58P-M117L-M216L, M211 L-P212D-D58P-M117V-M216A, M211 L-P212D- D58P-M117V-M216F, M211 L-P212D-D58P-M117V-M216L, M211 L-P212D-Y89A, M211 L-P212D- Y89A-M117A, M211 L-P212D-Y89A-M117F, M211 L-P212D-Y89A-M1171, M211 L-P212D-Y89A- M117L, M211 L-P212D-Y89A-M117V, M211 L-P212D-Y89A-M216A, M211 L-P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L, M211 L-P212D-Y89A-M117A-M216A, M211 L-P212D-Y89A-M117A- M216F, M211 L-P212D-Y89A-M117A-M216L, M211 L-P212D-Y89A-M117F-M216A, M211 L-P212D- Y89A-M117F-M216F, M211 L-P212D-Y89A-M117F-M216L, M211 L-P212D-Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A- M117L-M216A, M211 L-P212D-Y89A-M117L-M216F, M211 L-P212D-Y89A-M117L-M216L,M211 L-P212D-Y89A-M117V-M216A, M211 L-P212D-Y89A-M117V-M216F, M211 L-P212D-Y89A-M117V- M216L, M211 L-P212D-M117A, M211 L-P212D-M117F, M211 L-P212D-M117I, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L-P212D-M117A-M216F, M211 L-P212D- M117A-M216L, M211 L-P212D-M117F-M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L-P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L-P212D-M117L-M216F, M211 L-P212D-M117L-M216L, M211 L P212D-M117V-M216A, M211L-P212D-M117V-M216F, M211L-P212D-M117V-M216L, M211L-P212D-M216A, M211L-P212D-M216F, M211L-P212D-M216L, wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, the stability being determined as described in Example 3.

[0094] In preferred embodiments, the protease according to the invention is a protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length by at least 70% and increasingly preferably by at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, and in each case based on the numbering according to SEQ ID NO:1, has an amino acid substitution combination which is selected from the group consisting of M117A-M211 L-P212D, Y89A-M117A-M211 L-P212D, M117V-M211 L-P212D, A29G-M117V- M211 L-P212D, M117F-M211 L-P212D, M117I-M211 L-P212D, M117L-M211 L-P212D, M211 L-P212D- M216F, D58P-M211 L-P212D-M216A and M211 L-P212D-M216L, wherein the protease has improved stability in the presence of bleaching agents,in particular oxidizing agents, the stability being determined as described in Example 3.

[0095] In particularly preferred embodiments, the protease according to the invention comprises an amino acid substitution combination selected from the group consisting of I43V-A29G, I43V-A29G-D58P, I43V-A29G-Y89A, I43V-A29G-M117A, I43V-A29G-M117F, I43V-A29G-M117I, I43V-A29G-M117L, I43V-A29G-M117V, I43V-A29G-M216A, I43V-A29G-M216F, I43V-A29G-M216L, I43V-A29G-D58P-Y89A, I43V-A29G-D58P-M117A, I43V-A29G-D58P-M117F, I43V-A29G-D58P-M1171, I43V-A29G-D58P-M117L, I43V-A29G-D58P-M117V, I43V-A29G-D58P-M216A, I43V-A29G-D58P-M216F, I43V-A29G-D58P- M216L, I43V-A29G-Y89A-M117A, I43V-A29G-Y89A-M117F, I43V-A29G-Y89A-M1171, I43V-A29G- Y89A-M117L, I43V-A29G-Y89A-M117V, I43V-A29G-Y89A-M216A, I43V-A29G-Y89A-M216F, I43V-A29G-Y89A-M216L, I43V-A29G-M117A-M216A, I43V-A29G-M117A-M216F, I43V-A29G-M117A- M216L, I43V-A29G-D58P-Y89A-M117A, I43V-A29G-D58P-Y89A-M117F, I43V-A29G-D58P-Y89A- M117I, I43V-A29G-D58P-Y89A-M117L, I43V-A29G-D58P-Y89A-M117V, I43V-A29G-D58P-Y89A-M216A, I43V-A29G-D58P-Y89A-M216F, I43V-A29G-D58P-Y89A-M216L,I43V-A29G-Y89A-M117A- M216A, I43V-A29G-Y89A-M117A-M216F, I43V-A29G-Y89A-M117A-M216L, I43V-A29G-Y89A- M117F-M216A, I43V-A29G-Y89A-M117F-M216F, I43V-A29G-Y89A-M117F-M216L, I43V-A29G- Y89A-M117I-M216A, I43V-A29G-Y89A-M117I-M216F, I43V-A29G-Y89A-M117I-M216L, I43V-A29G- Y89A-M117L-M216A, I43V-A29G-Y89A-M117L-M216F, I43V-A29G-Y89A-M117L-M216L, I43V- A29G-Y89A-M117V-M216A, I43V-A29G-Y89A-M117V-M216F, I43V-A29G-Y89A-M117V-M216L, I43V-D58P, I43V-D58P-Y89A, I43V-D58P-M117A, I43V-D58P-M117F, I43V-D58P-M1171, I43V-D58P- M117L, I43V-D58P-M117V, I43V-D58P-M216A, I43V-D58P-M216F, I43V-D58P-M216L, I43V-D58P- Y89A-M117A, I43V-D58P-Y89A-M117F, I43V-D58P-Y89A-M1171, I43V-D58P-Y89A-M117L, I43V- D58P-Y89A-M117V, I43V-D58P-Y89A-M216A, I43V-D58P-Y89A-M216F, I43V-D58P-Y89A-M216L, I43V-D58P-M117A-M216A, I43V-D58P-M117A-M216F, I43V-D58P-M117A-M216L, I43V-D58P- M117F-M216A, I43V-D58P-M117F-M216F, I43V-D58P-M117F-M216L, I43V-D58P-M117I-M216A, I43V-D58P-M117I-M216F, I43V-D58P-M117I-M216L, I43V-D58P-M117L-M216A,I43V-D58P-M117L- M216F, I43V-D58P-M117L-M216L, I43V-D58P-M117V-M216A, I43V-D58P-M117V-M216F, I43V- D58P-M117V-M216L, I43V-Y89A, I43V-Y89A-M117A, I43V-Y89A-M117F, I43V-Y89A-M1171, I43V- Y89A-M117L, I43V-Y89A-M117V, I43V-Y89A-M216A, I43V-Y89A-M216F, I43V-Y89A-M216L, I43V- Y89A-M117A-M216A, I43V-Y89A-M117A-M216F, I43V-Y89A-M117A-M216L, I43V-Y89A-M117F- M216A, I43V-Y89A-M117F-M216F, I43V-Y89A-M117F-M216L, I43V-Y89A-M117I-M216A, I43V- Y89A-M117I-M216F, I43V-Y89A-M117I-M216L, I43V-Y89A-M117L-M216A, I43V-Y89A-M117L- M216F, I43V-Y89A-M117L-M216L, I43V-Y89A-M117V-M216A, I43V-Y89A-M117V-M216F, I43V- Y89A-M117V-M216L, I43V-M117A, I43V-M117F, I43V-M1171, I43V-M117L, I43V-M117V, I43V- M117A-M216A, I43V-M117A-M216F, I43V-M117A-M216L, I43V-M117F-M216A, I43V-M117F-M216F, I43V-M117F-M216L, I43V-M117I-M216A, I43V-M117I-M216F, I43V-M117I-M216L, I43V-M117L- M216A, I43V-M117L-M216F, I43V-M117L-M216L, I43V-M117V-M216A, I43V-M117V-M216F, I43V- M117V-M216L, I43V-M216A, I43V-M216F, I43V-M216L,M122L-N154S-T156A-A29G, M122L-N154S- T156A-A29G-D58P, M122L-N154S-T156A-A29G-Y89A, M122L-N154S-T156A-A29G-M117A, M122L- N154S-T156A-A29G-M117F, M122L-N154S-T156A-A29G-M117I, M122L-N154S-T156A-A29G- M117L, M122L-N154S-T156A-A29G-M117V, M122L-N154S-T156A-A29G-M216A, M122L-N154S- T156A-A29G-M216F, M122L-N154S-T156A-A29G-M216L, M122L-N154S-T156A-A29G-D58P-Y89A, M122L-N154S-T156A-A29G-D58P-M117A, M122L-N154S-T156A-A29G-D58P-M117F, M122L- N154S-T156A-A29G-D58P-M117I, M122L-N154S-T156A-A29G-D58P-M117L, M122L-N154S-T156A- A29G-D58P-M117V, M122L-N154S-T156A-A29G-D58P-M216A, M122L-N154S-T156A-A29G-D58P- M216F, M122L-N154S-T156A-A29G-D58P-M216L, M122L-N154S-T156A-A29G-Y89A-M117A, M122L-N154S-T156A-A29G-Y89A-M117F, M122L-N154S-T156A-A29G-Y89A-M117I, M122L-N154S- T156A-A29G-Y89A-M117L, M122L-N154S-T156A-A29G-Y89A-M117V, M122L-N154S-T156A-A29G- Y89A-M216A, M122L-N154S-T156A-A29G-Y89A-M216F, M122L-N154S-T156A-A29G-Y89A-M216L, M122L-N154S-T156A-A29G-M117A-M216A, M122L-N154S-T156A-A29G-M117A-M216F,M122L- N154S-T156A-A29G-M117A-M216L, M122L-N154S-T156A-A29G-D58P-Y89A-M117A, M122L- N154S-T156A-A29G-D58P-Y89A-M117F, M122L-N154S-T156A-A29G-D58P-Y89A-M117I, M122L- N154S-T156A-A29G-D58P-Y89A-M117L, M122L-N154S-T156A-A29G-D58P-Y89A-M117V, M122L- N154S-T156A-A29G-D58P-Y89A-M216A, M122L-N154S-T156A-A29G-D58P-Y89A-M216F, M122L- N154S-T156A-A29G-D58P-Y89A-M216L, M122L-N154S-T156A-A29G-Y89A-M117A-M216A, M122L- N154S-T156A-A29G-Y89A-M117A-M216F, M122L-N154S-T156A-A29G-Y89A-M117A-M216L, M122L-N154S-T156A-A29G-Y89A-M117F-M216A, M122L-N154S-T156A-A29G-Y89A-M117F- M216F, M122L-N154S-T156A-A29G-Y89A-M117F-M216L, M122L-N154S-T156A-A29G-Y89A-M117I- M216A, M122L-N154S-T156A-A29G-Y89A-M117I-M216F, M122L-N154S-T156A-A29G-Y89A-M117I- M216L, M122L-N154S-T156A-A29G-Y89A-M117L-M216A, M122L-N154S-T156A-A29G-Y89A- M117L-M216F, M122L-N154S-T156A-A29G-Y89A-M117L-M216L, M122L-N154S-T156A-A29G- Y89A-M117V-M216A, M122L-N154S-T156A-A29G-Y89A-M117V-M216F, M122L-N154S-T156A- A29G-Y89A-M117V-M216L,M122L-N154S-T156A-D58P, M122L-N154S-T156A-D58P-Y89A, M122L- N154S-T156A-D58P-M117A, M122L-N154S-T156A-D58P-M117F, M122L-N154S-T156A-D58P- M117I, M122L-N154S-T156A-D58P-M117L, M122L-N154S-T156A-D58P-M117V, M122L-N154S- T156A-D58P-M216A, M122L-N154S-T156A-D58P-M216F, M122L-N154S-T156A-D58P-M216L, M122L-N154S-T156A-D58P-Y89A-M117A, M122L-N154S-T156A-D58P-Y89A-M117F, M122L- N154S-T156A-D58P-Y89A-M117I, M122L-N154S-T156A-D58P-Y89A-M117L, M122L-N154S-T156A- D58P-Y89A-M117V, M122L-N154S-T156A-D58P-Y89A-M216A, M122L-N154S-T156A-D58P-Y89A- M216F, M122L-N154S-T156A-D58P-Y89A-M216L, M122L-N154S-T156A-D58P-M117A-M216A, M122L-N154S-T156A-D58P-M117A-M216F, M122L-N154S-T156A-D58P-M117A-M216L, M122L- N154S-T156A-D58P-M117F-M216A, M122L-N154S-T156A-D58P-M117F-M216F, M122L-N154S- T156A-D58P-M117F-M216L, M122L-N154S-T156A-D58P-M117I-M216A, M122L-N154S-T156A- D58P-M117I-M216F, M122L-N154S-T156A-D58P-M117I-M216L, M122L-N154S-T156A-D58P- M117L-M216A, M122L-N154S-T156A-D58P-M117L-M216F,M122L-N154S-T156A-D58P-M117L- M216L, M122L-N154S-T156A-D58P-M117V-M216A, M122L-N154S-T156A-D58P-M117V-M216F, M122L-N154S-T156A-D58P-M117V-M216L, M122L-N154S-T156A-Y89A, M122L-N154S-T156A- Y89A-M117A, M122L-N154S-T156A-Y89A-M117F, M122L-N154S-T156A-Y89A-M1171, M122L- N154S-T156A-Y89A-M117L, M122L-N154S-T156A-Y89A-M117V, M122L-N154S-T156A-Y89A- M216A, M122L-N154S-T156A-Y89A-M216F, M122L-N154S-T156A-Y89A-M216L, M122L-N154S- T156A-Y89A-M117A-M216A, M122L-N154S-T156A-Y89A-M117A-M216F, M122L-N154S-T156A- Y89A-M117A-M216L, M122L-N154S-T156A-Y89A-M117F-M216A, M122L-N 154S-T156A-Y89A- M117F-M216F, M122L-N154S-T156A-Y89A-M117F-M216L, M122L-N154S-T156A-Y89A-M117I- M216A, M122L-N154S-T156A-Y89A-M117I-M216F, M122L-N154S-T156A-Y89A-M117I-M216L, M122L-N154S-T156A-Y89A-M117L-M216A, M122L-N154S-T156A-Y89A-M117L-M216F, M122L- N 154S-T156A-Y89A-M 117L-M216L, M 122L-N 154S-T156A-Y89A-M 117V-M216A, M 122L-N 154S- T156A-Y89A-M117V-M216F, M122L-N154S-T156A-Y89A-M117V-M216L, M122L-N154S-T156A- M117A,M122L-N154S-T156A-M117F, M122L-N154S-T156A-M1171, M122L-N154S-T156A-M117L, M122L-N154S-T156A-M117V, M122L-N154S-T156A-M117A-M216A, M122L-N154S-T156A-M117A- M216F, M122L-N154S-T156A-M117A-M216L, M122L-N154S-T156A-M117F-M216A, M122L-N154S- T156A-M117F-M216F, M122L-N154S-T156A-M117F-M216L, M122L-N154S-T156A-M117I-M216A, M122L-N154S-T156A-M117I-M216F, M122L-N154S-T156A-M117I-M216L, M122L-N154S-T156A- M117L-M216A, M122L-N154S-T156A-M117L-M216F, M122L-N154S-T156A-M117L-M216L, M122L- N154S-T156A-M117V-M216A, M122L-N154S-T156A-M117V-M216F, M122L-N154S-T156A-M117V- M216L, M122L-N154S-T156A-M216A, M122L-N154S-T156A-M216F, M122L-N154S-T156A-M216L, M211 N-P212D-A29G, M211 N-P212D-A29G-D58P, M211 N-P212D-A29G-Y89A, M211 N-P212D- A29G-M117A, M211 N-P212D-A29G-M117F, M211 N-P212D-A29G-M117I, M211 N-P212D-A29G- M117L, M211 N-P212D-A29G-M117V, M211 N-P212D-A29G-M216A, M211 N-P212D-A29G-M216F, M211 N-P212D-A29G-M216L, M211 N-P212D-A29G-D58P-Y89A, M211 N-P212D-A29G-D58P-M117A,M211 N-P212D-A29G-D58P-M117F, M211 N-P212D-A29G-D58P-M117I, M211 N-P212D-A29G-D58P- M117L, M211 N-P212D-A29G-D58P-M117V, M211 N-P212D-A29G-D58P-M216A, M211 N-P212D- A29G-D58P-M216F, M211 N-P212D-A29G-D58P-M216L, M211 N-P212D-A29G-Y89A-M117A, M211 N-P212D-A29G-Y89A-M117F, M211 N-P212D-A29G-Y89A-M1171, M211 N-P212D-A29G-Y89A- M117L, M211 N-P212D-A29G-Y89A-M117V, M211 N-P212D-A29G-Y89A-M216A, M211 N-P212D- A29G-Y89A-M216F, M211 N-P212D-A29G-Y89A-M216L, M211 N-P212D-A29G-M117A-M216A, M211 N-P212D-A29G-M117A-M216F, M211 N-P212D-A29G-M117A-M216L, M211 N-P212D-A29G- D58P-Y89A-M117A, M211 N-P212D-A29G-D58P-Y89A-M117F, M211 N-P212D-A29G-D58P-Y89A- M117I, M211 N-P212D-A29G-D58P-Y89A-M117L, M211 N-P212D-A29G-D58P-Y89A-M117V, M211 N- P212D-A29G-D58P-Y89A-M216A, M211 N-P212D-A29G-D58P-Y89A-M216F, M211 N-P212D-A29G- D58P-Y89A-M216L, M211 N-P212D-A29G-Y89A-M117A-M216A, M211 N-P212D-A29G-Y89A-M117A- M216F, M211 N-P212D-A29G-Y89A-M117A-M216L, M211 N-P212D-A29G-Y89A-M117F-M216A,M211 N-P212D-A29G-Y89A-M117F-M216F, M211 N-P212D-A29G-Y89A-M117F-M216L, M211 N- P212D-A29G-Y89A-M117I-M216A, M211 N-P212D-A29— Y89A-M117I-M216F, M211 N-P212D-A29G- Y89A-M117I-M216L, M211 N-P212D-A29G-Y89A-M117L-M216A, M211 N-P212D-A29G-Y89A-M117L- M216F, M211 N-P212D-A29G-Y89A-M117L-M216L, M211 N-P212D-A29G-Y89A-M117V-M216A, M211 N-P212D-A29G-Y89A-M117V-M216F, M211 N-P212D-A29— Y89A-M117V-M216L, M211 N- P212D-D58P, M211 N-P212D-D58P-Y89A, M211 N-P212D-D58P-M117A, M211 N-P212D-D58P- M117F, M211 N-P212D-D58P-M117I, M211 N-P212D-D58P-M117L, M211 N-P212D-D58P-M117V, M211 N-P212D-D58P-M216A, M211 N-P212D-D58P-M216F, M211 N-P212D-D58P-M216L, M211 N- P212D-D58P-Y89A-M117A, M211 N-P212D-D58P-Y89A-M117F, M211 N-P212D-D58P-Y89A-M117I, M211 N-P212D-D58P-Y89A-M117L, M211 N-P212D-D58P-Y89A-M117V, M211 N-P212D-D58P-Y89A- M216A, M211 N-P212D-D58P-Y89A-M216F, M211 N-P212D-D58P-Y89A-M216L, M211 N-P212D- D58P-M117A-M216A, M211 N-P212D-D58P-M117A-M216F, M211 N-P212D-D58P-M117A-M216L,M211 N-P212D-D58P-M117F-M216A, M211 N-P212D-D58P-M117F-M216F, M211 N-P212D-D58P- M117F-M216L, M211 N-P212D-D58P-M117I-M216A, M211 N-P212D-D58P-M117I-M216F, M211 N- P212D-D58P-M117I-M216L, M211 N-P212D-D58P-M117L-M216A, M211 N-P212D-D58P-M117L- M216F, M211 N-P212D-D58P-M117L-M216L, M211 N-P212D-D58P-M117V-M216A, M211 N-P212D- D58P-M117V-M216F, M211 N-P212D-D58P-M117V-M216L, M211 N-P212D-Y89A, M211 N-P212D- Y89A-M117A, M211 N-P212D-Y89A-M117F, M211 N-P212D-Y89A-M1171, M211 N-P212D-Y89A- M117L, M211 N-P212D-Y89A-M117V, M211 N-P212D-Y89A-M216A, M211 N-P212D-Y89A-M216F, M211 N-P212D-Y89A-M216L, M211 N-P212D-Y89A-M117A-M216A, M211 N-P212D-Y89A-M117A- M216F, M211 N-P212D-Y89A-M117A-M216L, M211 N-P212D-Y89A-M117F-M216A, M211 N-P212D- Y89A-M117F-M216F, M211 N-P212D-Y89A-M117F-M216L, M211 N-P212D-Y89A-M117I-M216A, M211 N-P212D-Y89A-M117I-M216F, M211 N-P212D-Y89A-M117I-M216L, M211 N-P212D-Y89A- M117L-M216A, M211 N-P212D-Y89A-M117L-M216F, M211 N-P212D-Y89A-M117L-M216L,M211 N- P212D-Y89A-M117V-M216A, M211 N-P212D-Y89A-M117V-M216F, M211 N-P212D-Y89A-M117V- M216L, M211 N-P212D-M117A, M211 N-P212D-M117F, M211 N-P212D-M117I, M211N-P212D- M117L, M211 N-P212D-M117V, M211 N-P212D-M117A-M216A, M211 N-P212D-M117A-M216F, M211 N-P212D-M117A-M216L, M211 N-P212D-M117F-M216A, M211 N-P212D-M117F-M216F, M211 N-P212D-M117F-M216L, M211 N-P212D-M117I-M216A, M211 N-P212D-M117I-M216F, M211 N- P212D-M117I-M216L, M211 N-P212D-M117L-M216A, M211 N-P212D-M117L-M216F, M211 N-P212D- M117L-M216L, M211 N-P212D-M117V-M216A, M211 N-P212D-M117V-M216F, M211 N-P212D- M117V-M216L, M211 N-P212D-M216A, M211 N-P212D-M216F, M211 N-P212D-M216L, M211 L- P212D-A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211 L-P212D-A29G-M117A, M211 L-P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L- P212D-A29G-M117V, M211 L-P212D-A29G-M216A, M211 L-P212D-A29G-M216F, M211 L-P212D- A29G-M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P-M117A,M211 L-P212D- 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L-P212D-A29G-D58P-Y89A-M216L, D127P-M211 L-P212D- A29G-Y89A-M117A-M216A, D127P-M211 L-P212D-A29G-Y89A-M117A-M216F, D127P-M211 L- P212D-A29G-Y89A-M117A-M216L, D127P-M211 L-P212D-A29G-Y89A-M117F-M216A, D127P- M211 L-P212D-A29G-Y89A-M117F-M216F, D127P-M211 L-P212D-A29G-Y89A-M117F-M216L, D127P-M211 L-P212D-A29G-Y89A-M117I-M216A, D127P-M211 L-P212D-A29— Y89A-M117I-M216F, D127P-M211 L-P212D-A29G-Y89A-M117I-M216L, D127P-M211 L-P212D-A29G-Y89A-M117L-M216A, D127P-M211 L-P212D-A29G-Y89A-M117L-M216F, D127P-M211 L-P212D-A29G-Y89A-M117L- M216L, D127P-M211 L-P212D-A29G-Y89A-M117V-M216A, D127P-M211 L-P212D-A29G-Y89A- M117V-M216F, D127P-M211 L-P212D-A29G-Y89A-M117V-M216L, D127P-M211 L-P212D-D58P, D127P-M211 L-P212D-D58P-Y89A, D127P-M211 L-P212D-D58P-M117A, D127P-M211 L-P212D- D58P-M117F, D127P-M211 L-P212D-D58P-M117I, D127P-M211 L-P212D-D58P-M117L, D127P- M211 L-P212D-D58P-M117V, D127P-M211 L-P212D-D58P-M216A, D127P-M211 L-P212D-D58P- M216F,D127P-M211 L-P212D-D58P-M216L, D127P-M211 L-P212D-D58P-Y89A-M117A, D127P- M211 L-P212D-D58P-Y89A-M117F, D127P-M211 L-P212D-D58P-Y89A-M117I, D127P-M211 L- P212D-D58P-Y89A-M117L, D127P-M211 L-P212D-D58P-Y89A-M117V, D127P-M211 L-P212D-D58P- Y89A-M216A, D127P-M211 L-P212D-D58P-Y89A-M216F, D127P-M211 L-P212D-D58P-Y89A-M216L, D127P-M211 L-P212D-D58P-M117A-M216A, D127P-M211 L-P212D-D58P-M117A-M216F, D127P- M211 L-P212D-D58P-M117A-M216L, D127P-M211 L-P212D-D58P-M117F-M216A, D127P-M211 L- P212D-D58P-M117F-M216F, D127P-M211 L-P212D-D58P-M117F-M216L, D127P-M211 L-P212D- D58P-M117I-M216A, D127P-M211 L-P212D-D58P-M117I-M216F, D127P-M211 L-P212D-D58P- M117I-M216L, D127P-M211 L-P212D-D58P-M117L-M216A, D127P-M211 L-P212D-D58P-M117L- M216F, D127P-M211 L-P212D-D58P-M117L-M216L, D127P-M211 L-P212D-D58P-M117V-M216A, D127P-M211 L-P212D-D58P-M117V-M216F, D127P-M211 L-P212D-D58P-M117V-M216L, D127P- M211 L-P212D-Y89A, D127P-M211 L-P212D-Y89A-M117A, D127P-M211 L-P212D-Y89A-M117F, D127P-M211 L-P212D-Y89A-M1171,D127P-M211 L-P212D-Y89A-M117L, D127P-M211 L-P212D- Y89A-M117V, D127P-M211 L-P212D-Y89A-M216A, D127P-M211 L-P212D-Y89A-M216F, D127P- M211 L-P212D-Y89A-M216L, D127P-M211 L-P212D-Y89A-M117A-M216A, D127P-M211 L-P212D- Y89A-M117A-M216F, D127P-M211 L-P212D-Y89A-M117A-M216L, D127P-M211 L-P212D-Y89A- M117F-M216A, D127P-M211 L-P212D-Y89A-M117F-M216F, D127P-M211 L-P212D-Y89A-M117F- M216L, D127P-M211 L-P212D-Y89A-M117I-M216A, D127P-M211 L-P212D-Y89A-M117I-M216F, D127P-M211 L-P212D-Y89A-M117I-M216L, D127P-M211 L-P212D-Y89A-M117L-M216A, D127P- M211 L-P212D-Y89A-M117L-M216F, D127P-M211 L-P212D-Y89A-M117L-M216L, D127P-M211 L- P212D-Y89A-M117V-M216A, D127P-M211 L-P212D-Y89A-M117V-M216F, D127P-M211 L-P212D- Y89A-M117V-M216L, D127P-M211 L-P212D-M117A, D127P-M211 L-P212D-M117F, D127P-M211 L- P212D-M117I, D127P-M211 L-P212D-M117L, D127P-M211 L-P212D-M117V, D127P-M211L-P212D- M117A-M216A, D127P-M211 L-P212D-M117A-M216F, D127P-M211 L-P212D-M117A-M216L, D127P- M211 L-P212D-M117F-M216A,D127P-M211 L-P212D-M117F-M216F, D127P-M211 L-P212D-M117F- M216L, D127P-M211 L-P212D-M117I-M216A, D127P-M211 L-P212D-M117I-M216F, D127P-M211 L- P212D-M117I-M216L, D127P-M211 L-P212D-M117L-M216A, D127P-M211 L-P212D-M117L-M216F, D127P-M211 L-P212D-M117L-M216L, D127P-M211 L-P212D-M117V-M216A, D127P-M211 L-P212D- M117V-M216F, D127P-M211 L-P212D-M117V-M216L, D127P-M211 L-P212D-M216A, D127P-M211 L- P212D-M216F, D127P-M211 L-P212D-M216L, P212H-A29G, P212H-A29G-D58P, P212H-A29G- Y89A, P212H-A29G-M117A, P212H-A29G-M117F, P212H-A29G-M1171, P212H-A29G-M117L, P212H-A29G-M117V, P212H-A29G-M216A, P212H-A29G-M216F, P212H-A29G-M216L, P212H- A29G-D58P-Y89A, P212H-A29G-D58P-M117A, P212H-A29G-D58P-M117F, P212H-A29G-D58P- M117I, P212H-A29G-D58P-M117L, P212H-A29G-D58P-M117V, P212H-A29G-D58P-M216A, P212H- A29G-D58P-M216F, P212H-A29G-D58P-M216L, P212H-A29G-Y89A-M117A, P212H-A29G-Y89A- M117F, P212H-A29G-Y89A-M1171, P212H-A29G-Y89A-M117L, P212H-A29G-Y89A-M117V, P212H- A29G-Y89A-M216A, P212H-A29G-Y89A-M216F,P212H-A29G-Y89A-M216L, P212H-A29G-M117A- M216A, P212H-A29G-M117A-M216F, P212H-A29G-M117A-M216L, P212H-A29G-D58P-Y89A- M117A, P212H-A29G-D58P-Y89A-M117F, P212H-A29G-D58P-Y89A-M117I, P212H-A29G-D58P- Y89A-M117L, P212H-A29G-D58P-Y89A-M117V, P212H-A29G-D58P-Y89A-M216A, P212H-A29G- D58P-Y89A-M216F, P212H-A29G-D58P-Y89A-M216L, P212H-A29G-Y89A-M117A-M216A, P212H- A29G-Y89A-M117A-M216F, P212H-A29G-Y89A-M117A-M216L, P212H-A29G-Y89A-M117F-M216A, P212H-A29G-Y89A-M117F-M216F, P212H-A29G-Y89A-M117F-M216L, P212H-A29G-Y89A-M1171- M216A, P212H-A29G-Y89A-M117I-M216F, P212H-A29G-Y89A-M117I-M216L, P212H-A29G-Y89A- M117L-M216A, P212H-A29G-Y89A-M117L-M216F, P212H-A29G-Y89A-M117L-M216L, P212H- A29G-Y89A-M117V-M216A, P212H-A29G-Y89A-M117V-M216F, P212H-A29G-Y89A-M117V-M216L, P212H-D58P, P212H-D58P-Y89A, P212H-D58P-M117A, P212H-D58P-M117F, P212H-D58P-M1171, P212H-D58P-M117L, P212H-D58P-M117V, P212H-D58P-M216A, P212H-D58P-M216F, P212H- D58P-M216L, P212H-D58P-Y89A-M117A, P212H-D58P-Y89A-M117F,P212H-D58P-Y89A-M117I, P212H-D58P-Y89A-M117L, P212H-D58P-Y89A-M117V, P212H-D58P-Y89A-M216A, P212H-D58P- Y89A-M216F, P212H-D58P-Y89A-M216L, P212H-D58P-M117A-M216A, P212H-D58P-M117A- M216F, P212H-D58P-M117A-M216L, P212H-D58P-M117F-M216A, P212H-D58P-M117F-M216F, P212H-D58P-M117F-M216L, P212H-D58P-M117I-M216A, P212H-D58P-M117I-M216F, P212H- D58P-M117I-M216L, P212H-D58P-M117L-M216A, P212H-D58P-M117L-M216F, P212H-D58P- M117L-M216L, P212H-D58P-M117V-M216A, P212H-D58P-M117V-M216F, P212H-D58P-M117V- M216L, P212H-Y89A, P212H-Y89A-M117A, P212H-Y89A-M117F, P212H-Y89A-M1171, P212H- Y89A-M117L, P212H-Y89A-M117V, P212H-Y89A-M216A, P212H-Y89A-M216F, P212H-Y89A- M216L, P212H-Y89A-M117A-M216A, P212H-Y89A-M117A-M216F, P212H-Y89A-M117A-M216L, P212H-Y89A-M117F-M216A, P212H-Y89A-M117F-M216F, P212H-Y89A-M117F-M216L, P212H- Y89A-M117I-M216A, P212H-Y89A-M117I-M216F, P212H-Y89A-M117I-M216L, P212H-Y89A-M117L- M216A, P212H-Y89A-M117L-M216F, P212H-Y89A-M117L-M216L, P212H-Y89A-M117V-M216A, P212H-Y89A-M117V-M216F,P212H-Y89A-M117V-M216L, P212H-M117A, P212H-M117F, P212H- M117I, P212H-M117L, P212H-M117V, P212H-M117A-M216A, P212H-M117A-M216F, P212H- M117A-M216L, P212H-M117F-M216A, P212H-M117F-M216F, P212H-M117F-M216L, P212H-M117I- M216A, P212H-M117I-M216F, P212H-M117I-M216L, P212H-M117L-M216A, P212H-M117L-M216F, P212H-M117L-M216L, P212H-M117V-M216A, P212H-M117V-M216F, P212H-M117V-M216L, P212H-M216A, P212H-M216F, P212H-M216L, Q12L-M122L-A222S-A29G, Q12L-M122L-A222S- A29G-D58P, Q12L-M122L-A222S-A29G-Y89A, Q12L-M122L-A222S-A29G-M117A, Q12L-M122L- A222S-A29G-M117F, Q12L-M122L-A222S-A29G-M1171, Q12L-M122L-A222S-A29G-M117L, Q12L- M122L-A222S-A29G-M117V, Q12L-M122L-A222S-A29G-M216A, Q12L-M122L-A222S-A29G-M216F, Q12L-M122L-A222S-A29G-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A, Q12L-M122L-A222S- A29G-D58P-M117A, Q12L-M122L-A222S-A29G-D58P-M117F, Q12L-M122L-A222S-A29G-D58P- M117I, Q12L-M122L-A222S-A29G-D58P-M117L, Q12L-M122L-A222S-A29G-D58P-M117V, Q12L- M122L-A222S-A29G-D58P-M216A,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-D58P-M216F, Q12L-M122L-A222S-A29G-D58P-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A, Q12L-M122L-A222S-A29G-Y89A-M117F, Q12L-M122L-A222S-A29G-Y89A-M117I, Q12L-M122L-A222S-A29G-Y89A-M117L, Q12L-M122L-A222S-A29G-Y89A-M117V, Q12L-M122L-A222S-A29G-Y89A-M216A, Q12L-M122L-A222S-A29G-Y89A-M216F, Q12L-M122L-A222S-A29G-Y89A-M216L, Q12L-M122L-A222S-A29G-M117A-M216A, Q12L-M122L-A222S-A29G-M117A-M216F, Q12L-M122L-A222S-A29G-M117A-M216L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117A, Q12L-M122L-A222S-A29G-D58P-Y89A-M117F, Q12L-M122L-A222S-A29G-D58P-Y89A-M117I, Q12L-M122L-A222S-A29G-D58P-Y89A-M117L, Q12L-M122L-A222S-A29G-D58P-Y89A-M117V, Q12L-M122L-A222S-A29G-D58P-Y89A-M216A, Q12L-M122L-A222S-A29G-D58P-Y89A-M216F, Q12L-M122L-A222S-A29G-D58P-Y89A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117A-M216A, Q12L-M122L-A222S-A29G-Y89A-M117A-M216F, Q12L-M122L-A222S-A29G-Y89A-M117A-M216L, Q12L-M122L-A222S-A29G-Y89A-M117F-M216A, Q12L-M122L-A222S-A29G-Y89A-M117F-M216F,<h2 style=";text-align:left;direction:ltr">Q12L-M122L-A222S-A29G-Y89A-M117F-M216L, Q12L-M122L-A222S-A29G-Y89A-M117I-M216A, Q12L-M122L-A222S-A29G-Y89A-M117I-M216F, Q12L-M122L-A222S-A29G-Y89A-M117I-M216L, Q12L-M122L-A222S-A29G-Y89A-M117L-M216A, Q12L-M122L-A222S-A29G-Y89A-M117L-M216F, Q12L-M122L-A222S-A29G-Y89A-M117L-M216L, Q12L-M122L-A222S-A29G-Y89A-M117V-M216A, Q12L-M122L-A222S-A29G-Y89A-M117V-M216F, Q12L-M122L-A222S-A29G-Y89A-M117V-M216L, Q12L-M122L-A222S-D58P, Q12L-M122L-A222S-D58P-Y89A, Q12L-M122L-A222S-D58P-M117A, Q12L-M122L-A222S-D58P-M117F, Q12L-M122L- A222S-D58P-M1171, Q12L-M122L-A222S-D58P-M117L, Q12L-M122L-A222S-D58P-M117V, Q12L- M122L-A222S-D58P-M216A, Q12L-M122L-A222S-D58P-M216F, Q12L-M122L-A222S-D58P-M216L, Q12L-M122L-A222S-D58P-Y89A-M117A, Q12L-M122L-A222S-D58P-Y89A-M117F, Q12L-M122L-A222S-D58P-Y89A-M1171, Q12L-M122L-A222S-D58P-Y89A-M117L, Q12L-M122L-A222S-D58P-Y89A-M117V, Q12L-M122L-A222S-D58P-Y89A-M216A, Q12L-M122L-A222S-D58P-Y89A-M216F, Q12L-M122L-A222S-D58P-Y89A-M216L, Q12L-M122L-A222S-D58P-M117A-M216A,<h2 style=";text-align:left;direction:ltr">Q12L-M122L- A222S-D58P-M117A-M216F, Q12L-M122L-A222S-D58P-M117A-M216L, Q12L-M122L-A222S-D58P- M117F-M216A, Q12L-M122L-A222S-D58P-M117F-M216F, Q12L-M122L-A222S-D58P-M117F- M216L, Q12L-M122L-A222S-D58P-M117I-M216A, Q12L-M122L-A222S-D58P-M117I-M216F, Q12L- M122L-A222S-D58P-M117I-M216L, Q12L-M122L-A222S-D58P-M117L-M216A, Q12L-M122L-A222S- D58P-M117L-M216F, Q12L-M122L-A222S-D58P-M117L-M216L, Q12L-M122L-A222S-D58P-M117V- M216A, Q12L-M122L-A222S-D58P-M117V-M216F, Q12L-M122L-A222S-D58P-M117V-M216L, Q12L-M122L-A222S-Y89A, Q12L-M122L-A222S-Y89A-M117A, Q12L-M122L-A222S-Y89A-M117F, Q12L-M122L-A222S-Y89A-M1171, Q12L-M122L-A222S-Y89A-M117L, Q12L-M122L-A222S-Y89A-M117V, Q12L-M122L-A222S-Y89A-M216A, Q12L-M122L-A222S-Y89A-M216F, Q12L-M122L-A222S-Y89A-M216L, Q12L-M122L-A222S-Y89A-M117A-M216A, Q12L-M122L-A222S-Y89A-M117A-M216F, Q12L-M122L-A222S-Y89A-M117A-M216L, Q12L-M122L-A222S-Y89A-M117F-M216A, Q12L-M122L-A222S-Y89A-M117F-M216F, Q12L-M122L-A222S-Y89A-M117F-M216L, Q12L-M122L-A222S-Y89A-M117I-M216A,Q12L-M122L-A222S-Y89A-M117I-M216F, Q12L-M122L-A222S-Y89A-M117I-M216L, Q12L-M122L-A222S-Y89A-M117L-M216A, Q12L-M122L-A222S-Y89A-M117L-M216F, Q12L-M122L- A222S-Y89A-M117L-M216L, Q12L-M122L-A222S-Y89A-M117V-M216A, Q12L-M122L-A222S-Y89A-M117V-M216F, Q12L-M122L-A222S-Y89A-M117V-M216L, Q12L-M122L-A222S-M117A, Q12L-M122L-A222S-M117F, Q12L-M122L-A222S-M1171, Q12L-M122L-A222S-M117L, Q12L-M122L- A222S-M117V, Q12L-M122L-A222S-M117A-M216A, Q12L-M122L-A222S-M117A-M216F, Q12L- M122L-A222S-M117A-M216L, Q12L-M122L-A222S-M117F-M216A, Q12L-M122L-A222S-M117F-M216F, Q12L-M122L-A222S-M117F-M216L, Q12L-M122L-A222S-M117I-M216A, Q12L-M122L-A222S-M117I-M216F, Q12L-M122L-A222S-M117I-M216L, Q12L-M122L-A222S-M117L-M216A, Q12L-M122L-A222S-M117L-M216F, Q12L-M122L-A222S-M117L-M216L, Q12L-M122L-A222S- M117V-M216A, Q12L-M122L-A222S-M117V-M216F, Q12L-M122L-A222S-M117V-M216L, Q12L- M122L-A222S-M216A, Q12L-M122L-A222S-M216F, Q12L-M122L-A222S-M216L existing group is selected,wherein the numbering is based in each case on the numbering according to SEQ ID NO:1, wherein the protease comprises no further changes besides the amino acid substitutions mentioned, and wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, wherein the stability is determined as described in Example 3.,

[0096] In preferred embodiments, the protease of the invention comprises an M211 L-P212D- A29G, M211 L-P212D-A29G-D58P, M211 L-P212D-A29G-Y89A, M211A L-P212D-A29G-M117A, M211 L- P212D-A29G-M117F, M211 L-P212D-A29G-M1171, M211 L-P212D-A29G-M117L, M211 L-P212D-M-M117G-M1172 L-P212D-A29G-M216A, M211 L-P212D-A29G-M216F, M211 L-P212D-A29G- M216L, M211 L-P212D-A29G-D58P-Y89A, M211 L-P212D-A29G-D58P-M117A, M211 L-P212D-A29G- D58P-M117F, M211 L-P212D-A29G-D58P-M117I, M211 L-P212D-A29G-D-M117L, M217L L-P212D- A29G-D58P-M117V, M211 L-P212D-A29G-D58P-M216A, M211 L-P212D-A29G-D58P-M216F, M211 L- P212D-A29G-M-D216L, M216L L-P212D-A29G-Y89A-M117A, M211 L-P212D-A29G-Y89A-M117F, M211 L-P212D-A29G-Y89A-M117I, M211 L-P212D-A29G-M-Y117L, M217L L-P212D-A29G-Y89A- M117V, M211 L-P212D-A29G-Y89A-M216A, M211 L-P212D-A29G-Y89A-M216F, M211 L-P212D- A29G-M-Y216L, M216L L-P212D-A29G-M117A-M216A, M211 L-P212D-A29G-M117A-M216F, M211 L-P212D-A29G-M117A-M216L, M211 L-P212D-A29A-M217A-YM211 L-P212D- A29G-D58P-Y89A-M117F, M211 L-P212D-A29G-D58P-Y89A-M117I, M211 L-P212D-A29G-D58P- Y89A-M117L, M211 L-P212D-A29G-D58P-Y89A-M117V, M211 L-P212D-A29G-D58P-Y89A-M216A, M211 L-P212D-A29G-D58P-Y89A-M216F, M211 L-P212D-A29G-D58P-Y89A-M216L, M211 L-P212D- A29G-Y89A-M117A-M216A, M211 L-P212D-A29G-Y89A-M117A-M216F, M211 L-P212D-A29G-Y89A- M117A-M216L, M211 L-P212D-A29G-Y89A-M117F-M216A, M211 L-P212D-A29G-Y89A-M117F- M216F, M211 L-P212D-A29G-Y89A-M117F-M216L, M211 L-P212D-A29G-Y89A-M117I-M216A,

[0097] M211 L-P212D-A29G-Y89A-M117I-M216F, M211 L-P212D-A29G-Y89A-M117I-M216L, M211 L-P212D- A29G-Y89A-M117L-M216A, M211 L-P212D-A29G-Y89A-M117L-M216F, M211 L-P212D-A29G-Y89A- M117L-M216L, M211 L-P212D-A29G-Y89A-M117V-M216A, M211 L-P212D-A29G-Y89A-M117V- M216F, M211 L-P212D-A29G-Y89A-M117V-M216L, M211 L-P212D-D58P, M211 L-P212D-D58P- Y89A, M211 L-P212D-D58P-M117A, M211 L-P212D-D58P-M117F, M211 L-P212D-D58P-M117I, M211 L-P212D-D58P-M117L, M211 L-P212D-D58P-M117V, M211 L-P212D-D58P-M216A, M211 L- P212D-D58P-M216F, M211 L-P212D-D58P-M216L, M211 L-P212D-D58P-Y89A-M117A, M211 L- P212D-D58P-Y89A-M117F, M211 L-P212D-D58P-Y89A-M117I, M211 L-P212D-D58P-Y89A-M117L, M211 L-P212D-D58P-Y89A-M117V, M211 L-P212D-D58P-Y89A-M216A, M211 L-P212D-D58P-Y89A- M216F, M211 L-P212D-D58P-Y89A-M216L, M211 L-P212D-D58P-M117A-M216A, M211 L-P212D- D58P-M117A-M216F, M211 L-P212D-D58P-M117A-M216L, M211 L-P212D-D58P-M117F-M216A, M211 L-P212D-D58P-M117F-M216F, M211 L-P212D-D58P-M117F-M216L, M211 L-P212D-D58P- M117I-M216A,M211 L-P212D-D58P-M117I-M216F, M211 L-P212D-D58P-M117I-M216L, M211 L- P212D-D58P-M117L-M216A, M211 L-P212D-D58P-M117L-M216F, M211 L-P212D-D58P-M117L- M216L, M211 L-P212D-D58P-M117V-M216A, M211 L-P212D-D58P-M117V-M216F, M211 L-P212D- D58P-M117V-M216L, M211 L-P212D-Y89A, M211 L-P212D-Y89A-M117A, M211 L-P212D-Y89A- M117F, M211 L-P212D-Y89A-M1171, M211 L-P212D-Y89A-M117L, M211 L-P212D-Y89A-M117V, M211 L-P212D-Y89A-M216A, M211 L-P212D-Y89A-M216F, M211 L-P212D-Y89A-M216L, M211 L- P212D-Y89A-M117A-M216A, M211 L-P212D-Y89A-M117A-M216F, M211 L-P212D-Y89A-M117A- M216L, M211 L-P212D-Y89A-M117F-M216A, M211 L-P212D-Y89A-M117F-M216F, M211 L-P212D- Y89A-M117F-M216L, M211 L-P212D-Y89A-M117I-M216A, M211 L-P212D-Y89A-M117I-M216F, M211 L-P212D-Y89A-M117I-M216L, M211 L-P212D-Y89A-M117L-M216A, M211 L-P212D-Y89A- M117L-M216F, M211 L-P212D-Y89A-M117L-M216L, M211 L-P212D-Y89A-M117V-M216A, M211 L- P212D-Y89A-M117V-M216F, M211 L-P212D-Y89A-M117V-M216L, M211 L-P212D-M117A, M211 L- P212D-M117F,M211 L-P212D-M1171, M211 L-P212D-M117L, M211 L-P212D-M117V, M211 L-P212D-M117A-M216A, M211 L-P212D-M117A-M216F, M211 L-P212D-M117A-M216L, M211 L-P212D-M117F- M216A, M211 L-P212D-M117F-M216F, M211 L-P212D-M117F-M216L, M211 L-P212D-M117I-M216A, M211 L-P212D-M117I-M216F, M211 L-P212D-M117I-M216L, M211 L-P212D-M117L-M216A, M211 L- P212D-M117L-M216F, M211 L-P212D-M117L-M216L, M211 L-P212D-M117V-M216A, M211 L-P212D-M117V-M216F, M211 L-P212D-M117V-M216L, M211 L-P212D-M216A, M211 L-P212D-M216F, M211 L-P212D-M216L existing group is selected, wherein the numbering is based in each case on the numbering according to SEQ ID NO:1, wherein the protease comprises no further changes besides the amino acid substitutions mentioned, and wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, wherein the stability is determined as described in Example 3.,

[0098] In preferred embodiments, the protease according to the invention comprises an amino acid substitution combination selected from the group consisting of M117A-M211 L-P212D, Y89A-M117A-M211 L-P212D, M117V-M211 L-P212D, A29G-M117V-M211 L-P212D, M117F-M211 L-P212D, M117I-M211 L-P212D, M117L-M211 L-P212D, M211 L-P212D-M216F, D58P-M211 L-P212D-M216A and M211 L-P212D-M216L, wherein the numbering is in each case based on the numbering according to SEQ ID NO:1, wherein the Protease comprises no further changes besides the amino acid substitutions mentioned, and wherein the protease has improved stability in the presence of bleaching agents, in particular oxidizing agents, the stability being determined as described in Example 3.

[0099] Proteases according to the invention have increased catalytic activity in washing and cleaning agents, in particular washing and cleaning agents containing bleach, preferably automatic dishwashing agents, particularly preferably automatic dishwashing agents containing bleach. In various embodiments, the proteases according to the invention can have a proteolytic activity of at least 101%, 102%, 103%, 104%, 105%, 106%, 107%, 108%, 109%, 110%, 111%, 112%, 113%, 114%, 115%, 116%, 117%, 118%, 119%, 120%, 121%, 122%, 123%, 124%, 125%, 126%, 127%, 128%, 129%, 130%, or more, based on the wild type (SEQ ID NO:1). Such performance-enhanced proteases enable improved cleaning results on protease-sensitive soils. Such improved cleaning results on protease-sensitive soils can be achieved in different temperature ranges, e.g.in a range of about 0°C to about 100°C, preferably about 20°C to about 75°C, more preferably about 30°C to about 60°C, most preferably about 40°C to about 55°C.

[0100] The proteases according to the invention have high stability in detergents and cleaning agents, in particular detergents and cleaning agents containing bleach, preferably automatic dishwashing detergents, particularly preferably automatic dishwashing detergents containing bleach. In preferred embodiments, proteases according to the invention also have high stability, e.g., towards surfactants and / or chelators, and / or towards temperature influences, in particular towards high temperatures, e.g., between about 50°C and about 65°C, in particular about 60°C, and / or towards acidic or alkaline conditions and / or towards pH changes and / or towards denaturing or oxidizing agents and / or towards (auto)proteolytic degradation and / or towards a change in redox conditions.

[0101] The proteases according to the invention exhibit enzymatic activity, i.e., they are capable of hydrolyzing peptides and proteins, particularly in detergents and cleaning agents. A protease according to the invention is therefore an enzyme that catalyzes the hydrolysis of amide / peptide bonds in protein / peptide substrates and is thus capable of cleaving proteins or peptides.

[0102] Furthermore, a protease according to the invention is preferably a mature protease, i.e., the catalytically active molecule without signal and / or propeptide(s). Unless otherwise stated, the sequences indicated also refer to mature (processed) enzymes.

[0103] In various embodiments of the invention, the protease is a free enzyme. This means that the protease can interact directly with all components of a composition and, if the composition is a liquid composition, that the protease is in direct contact with the composition's solvent (e.g., water). In other embodiments, a composition may contain proteases that form an interaction complex with other molecules or that contain a "coat." In this case, a single or multiple protease molecules may be separated from the other components of the composition by a surrounding structure. Such a separating structure may be formed by, but is not limited to, vesicles, such as a micelle or a liposome. The surrounding structure may also be a virus particle, a bacterial cell, or a eukaryotic cell. In various embodiments, a composition may contain cells of, for example,Bacillus pumilus or Bacillus subtilis or other expression strains expressing the proteases according to the invention, or cell culture supernatants of such cells.

[0104] The identity of nucleic acid or amino acid sequences is determined by sequence comparison. This sequence comparison is based on the BLAST algorithm, which is established and commonly used in the state of the art (see, for example, Altschul et al., Basic local alignment search tool, J. Mol. Biol., 1990, 215:403-410, and Altschul et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Res., 1997, 25:3389-3402) and is essentially achieved by matching similar sequences of nucleotides or amino acids in the nucleic acid or amino acid sequences to one another. A tabular assignment of the relevant positions is referred to as an alignment. Another algorithm available in the state of the art is the FASTA algorithm. Sequence comparisons (alignments), especially multiple sequence comparisons, are created using computer programs. Frequently used are, for example, the Clustal series (see e.g. Chenna et al., Multiple sequence alignment with the Clustal series of programs, Nucleic Acid Res., 2003, 31:3497-3500), T-Coffee (cf. e.g. Notredame et al., T-Coffee: A novel method for multiple sequence alignments, J. Mol. Biol., 2000, 302:205-217) or programs based on these programs or algorithms. Furthermore, sequence comparisons (alignments) are possible using the computer program Vector NTI® Suite 10.3 (Invitrogen Corporation, 1600 Faraday Avenue, Carlsba...

Claims

PATENT CLAIMS 1. A protease which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1 , (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

2. Protease according to claim 1, which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1 , (i) at least two of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least two amino acid substitutions selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

3. Protease according to claim 1 or 2, which has proteolytic activity and comprises an amino acid sequence which corresponds to the amino acid sequence given in SEQ ID NO:1 over its entire length to at least 70% and increasingly preferably to at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5% or 99% identical, wherein the protease, in each case based on the numbering according to SEQ ID NO:1 , (i) at least one, preferably two, of the positions corresponding to positions 211 and 212, at least one, preferably two amino acid substitution(s) selected from the group consisting of M211 N, M211 L, P212D and P212H, preferably M211 L and / or P212D, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L.

4. Protease according to one of claims 1 to 3, wherein the amino acid substitution or amino acid substitution combination from group (i) is selected from the group consisting of I43V, M122L-N154S-T156A, M211 N-P212D, M211 L-P212D, G160S, D127P-M211 L-P212D, P212H and Q12L-M122L-A222S and the amino acid substitution or amino acid substitution combination from group (ii) is selected from the group consisting of A29G, A29G-D58P, A29G-Y89A, A29G-M117A, A29G-M117F, A29G-M1171, A29G-M117L, A29G-M117V, A29G-M216A, A29G-M216F, A29G-M216L, A29G-D58P-Y89A, A29G-D58P-M117A, A29G-D58P-M117F, A29G-D58P-M1171, A29G-D58P-M117L, A29G-D58P-M117V, A29G-D58P-M216A, A29G-D58P-M216F, A29G-D58P-M216L, A29G-Y89A-M117A, A29G-Y89A-M117F, A29G-Y89A-M117I, A29G-Y89A-M117L, A29G-Y89A-M117V, A29G-Y89A-M216A, A29G-Y89A-M216F, A29G-Y89A-M216L, A29G-M117A-M216A, A29G-M117A-M216F, A29G-M117A-M216L, A29G-D58P-Y89A-M117A, A29G-D58P-Y89A-M117F, A29G-D58P-Y89A-M1171, A29G-D58P-Y89A-M117L, A29G-D58P-Y89A-M117V, A29G-D58P-Y89A-M216A,A29G-D58P-Y89A-M216F, A29G-D58P-Y89A- M216L, A29G-Y89A-M117A-M216A, A29G-Y89A-M117A-M216F, A29G-Y89A-M117A-M216L, A29G- Y89A-M117F-M216A, A29G-Y89A-M117F-M216F, A29G-Y89A-M117F-M216L, A29G-Y89A-M1171- M216A, A29G-Y89A-M117I-M216F, A29G-Y89A-M117I-M216L, A29G-Y89A-M117L-M216A, A29G- Y89A-M117L-M216F, A29G-Y89A-M117L-M216L, A29G-Y89A-M117V-M216A, A29G-Y89A-M117V- M216F, A29G-Y89A-M117V-M216L, D58P, D58P-Y89A, D58P-M117A, D58P-M117F, D58P-M1171, D58P-M117L, D58P-M117V, D58P-M216A, D58P-M216F, D58P-M216L, D58P-Y89A-M117A, D58P- Y89A-M117F, D58P-Y89A-M1171, D58P-Y89A-M117L, D58P-Y89A-M117V, D58P-Y89A-M216A, D58P-Y89A-M216F, D58P-Y89A-M216L, D58P-M117A-M216A, D58P-M117A-M216F, D58P-M117A- M216L, D58P-M117F-M216A, D58P-M117F-M216F, D58P-M117F-M216L, D58P-M117I-M216A, D58P-M117I-M216F, D58P-M117I-M216L, D58P-M117L-M216A, D58P-M117L-M216F, D58P-M117L- M216L, D58P-M117V-M216A, D58P-M117V-M216F, D58P-M117V-M216L, Y89A, Y89A-M117A, Y89A-M117F, Y89A-M1171, Y89A-M117L, Y89A-M117V, Y89A-M216A,Y89A-M216F, Y89A-M216L, Y89A-M117A-M216A, Y89A-M117A-M216F, Y89A-M117A-M216L, Y89A-M117F-M216A, Y89A-M117F-M216F, Y89A-M117F-M216L, Y89A-M117I-M216A, Y89A-M117I-M216F, Y89A-M1171-M216L, Y89A-M117L-M216A, Y89A-M117L-M216F, Y89A-M117L-M216L, Y89A-M117V-M216A, Y89A-M117V-M216F, Y89A-M117V-M216L, M117A, M117F, M117I, M117L, M117V, M117A-M216A, M117A-M216F, M117A-M216L, M117F-M216A, M117F-M216F, M117F-M216L, M117I-M216A, M117I-M216F, M117I-M216L, M117L-M216A, M117L-M216F, M117L-M216L, M117V-M216A, M117V-M216F, M117V-M216L, M216A, M216F, M216L, preferably M117A, M117A-Y89L, M117V, M117V-A29G, M117F, M117I, M117L, M216F, D58P-M216A, M216L, each with reference to the numbering according to SEQ ID NO:

1.

5. Protease, characterized in that (a) it is obtainable from a protease according to any one of claims 1 to 4 as starting molecule by single or multiple conservative amino acid substitution, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L; (b) it is obtainable from a protease according to any one of claims 1 to 4 as starting molecule by fragmentation, deletion, insertion or substitution mutagenesis and comprises an amino acid sequence which corresponds to the starting molecule over a length of at least 190, 200, 210, 220, 230, 240, 250, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268 or 269 contiguous amino acids, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I,M117L, M117V, M216A, M216F and M216L., 6. A process for producing a protease, comprising introducing (i) at least one amino acid substitution at at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, based on the numbering according to SEQ ID NO:1, selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one amino acid substitution at at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, based on the numbering according to SEQ ID NO:1, selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A, M216F and M216L, in a starting molecule having an amino acid sequence which is at least 70% and increasingly preferably at least 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 90.5%, 91%, 91.5%, 92%, 92.5%, 93%, 93.5%, 94%, 94.5%, 95%, 95.5%, 96%, 96.5%, 97%, 97.5%, 98%, 98.5%, 99%, 99.5% or 100% has sequence identity with the amino acid sequence given in SEQ ID NO:1 over its entire length.

7. The method according to claim 6, further comprising one or more of the following method steps: (a) introducing a single or multiple conservative amino acid substitution, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M1171, M117L, M117V, M216A, M216F and M216L; (b) altering the amino acid sequence by fragmentation, deletion, insertion or substitution mutagenesis such that the protease comprises an amino acid sequence which corresponds to the starting molecule over a length of at least 190, 200, 210, 220, 230, 240, 250, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268 or 269 contiguous amino acids, wherein the protease, in each case based on the numbering according to SEQ ID NO:1, (i) at least one of the positions corresponding to positions 12, 43, 122, 127, 154, 156, 160, 211, 212 and 222, at least one amino acid substitution selected from the group consisting of Q12L, I43V, M122L, D127P, N154S, T156A, G160S, M211N, M211L, P212D, P212H and A222S, and (ii) at least one of the positions corresponding to positions 29, 58, 89, 117 and 216, at least one amino acid substitution selected from the group consisting of A29G, D58P, Y89A, M117A, M117F, M117I, M117L, M117V, M216A,M216F and M216L consisting of a group selected., 8. Nucleic acid encoding a protease according to any one of claims 1 to 5 or encoding a protease obtained by a process of claims 6 to 7.

9. Vector containing a nucleic acid according to claim 8, in particular a cloning vector or an expression vector.

10. A non-human host cell comprising a nucleic acid according to claim 8 or a vector according to claim 9, or comprising a protease according to any one of claims 1 to 5, or comprising a protease obtained by a process of claims 6 to 7, in particular one which secretes the protease into the medium surrounding the host cell.

11. A process for producing a protease comprising a) culturing a host cell according to claim 10 and b) isolating the protease from the culture medium or from the host cell.

12. Washing or cleaning agent, in particular washing or cleaning agent containing bleach, preferably automatic dishwashing agent, particularly preferably automatic dishwashing agent containing bleach, characterized in that it contains at least one protease according to one of claims 1 to 5 or a protease obtained by a process according to claims 6 to 7.

13. A method for cleaning textiles and / or hard surfaces, in particular dishes, characterized in that a washing or cleaning agent according to claim 12 is used in at least one method step.

14. Use of a protease according to any one of claims 1 to 5 or a protease obtained by a process of claims 6 to 7 in a washing or cleaning agent, in particular a washing or cleaning agent containing bleach, preferably a dishwasher detergent, particularly preferably a dishwasher detergent containing bleach, for cleaning textiles and / or hard surfaces, in particular dishes.

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