Colloidal sulfur Anti-inflammatory and Anti-bacterial agent, and preparation method therefor and use thereof

Abstract

A colloidal sulfur anti-inflammatory and anti-bacterial agent, and a preparation method therefor and the use thereof. The colloidal sulfur anti-inflammatory and anti-bacterial agent comprises sulfur, xanthan gum, a gum arabic extract, Tamarindus indica seed gum, sclerotium gum and water. The preparation method comprises the following steps: S1. mixing the xanthan gum, gum arabic extract, Tamarindus indica seed gum and sclerotium gum to obtain a wrapping layer; S2. wrapping the sulfur using the wrapping layer to obtain an intermediate product; and S3, blending the intermediate product with water, and performing jet milling mixing to obtain the colloidal sulfur anti-inflammatory and anti-bacterial agent. The present invention can be used in shampoos, shower gels, serums and creams.

Description

A colloidal sulfur anti-inflammatory and antibacterial agent and its preparation method and application Technical Field

[0001] The present invention relates to the field of daily chemical industry, and in particular to a colloidal sulfur anti-inflammatory and antibacterial agent, a preparation method and application thereof. Background Art

[0002] The skin is the largest organ in the human body. Diseases caused by skin damage are numerous and complex. Biological damage, such as parasitic and bacterial infections, is particularly common. Among the many antimicrobial agents, colloidal sulfur exhibits superior performance. Also known as delta-sulfur, colloidal sulfur is a very fine, water-suspended elemental sulfur. Upon contact with skin and tissue secretions, it produces hydrogen sulfide and polythionic acid, which inhibit the growth of parasites and bacteria. It has antibacterial and anti-inflammatory effects on the skin, controls oil and removes acne, and unclogs pores. As a highly effective anti-inflammatory and antimicrobial agent, it is used in cosmetics and pharmaceuticals.

[0003] However, colloidal sulfur is currently used more in pesticides, and its application in cosmetics and pharmaceuticals is limited. This is mainly because: colloidal sulfur is an allotrope of sulfur and generally has a pungent, special sulfur odor, which easily stains clothing and causes discomfort to users; in addition, colloidal sulfur has poor water solubility and the dispersion system is not uniform and stable enough, so large-scale contact with the skin can easily cause allergic reactions.

[0004] Existing technologies, such as CN107536758A, disclose a sulfur-containing essence liquid that uses xanthan gum and a variety of other organic additives to stabilize the suspension. However, due to the excessive use of organic additives, there may be problems such as technical complexity and environmental friendliness.

[0005] In summary, there is an urgent need to develop a method for preparing colloidal sulfur to improve the suspension, stability and sustained-release properties of colloidal sulfur and broaden its application range in the fields of cosmetics, medicine and the like. Summary of the Invention

[0006] The present invention provides a colloidal sulfur anti-inflammatory and antibacterial agent, a preparation method and an application thereof. The present invention enhances the antibacterial and anti-inflammatory effects of colloidal sulfur, while improving the stability, bioaffinity and sustained-release function of the product, thereby overcoming the defects existing in the prior art.

[0007] One object of the present invention is to provide a colloidal sulfur anti-inflammatory and antibacterial agent, wherein the colloidal sulfur anti-inflammatory and antibacterial agent comprises the following components in parts by weight:

[0008] 40-50 parts of sulfur

[0009] 2-5 parts xanthan gum

[0010] 2-5 parts of acacia gum extract

[0011] 2-5 parts sour bean seed gum

[0012] 2-5 parts of Sclerotium gum

[0013] solvent.

[0014] Furthermore, the molecular weight of the gum arabic extract is 5×10 4 ~20×10 4 The content of active ingredients (such as gum, amino acids and proteins) in the gum arabic extract is greater than 99%.

[0015] Furthermore, the molecular weight of the xanthan gum is 2×10 6 ~20×10 6 The content of active ingredients (polysaccharide polymer compounds) in the xanthan gum is greater than 99%.

[0016] Furthermore, the molecular weight of the sour bean seed gum is 7×10 5 ~15×10 6 The content of active ingredient (tamarind seed polysaccharide) in the tamarind seed gum is greater than 99%.

[0017] Furthermore, the molecular weight of the sclerotium gum is 0.8-1.2 kDa, and the content of the active ingredient (scleroglucan) in the sclerotium gum is greater than 99%.

[0018] Furthermore, the viscosity of the colloidal sulfur anti-inflammatory and antibacterial agent is 1500-10000 mPa·s (25° C.).

[0019] The xanthan gum, gum arabic extract, tamarind gum, and sclerotium gum used in the present invention serve as coating materials. The coating layer allows the sulfur to exist in a colloidal form in the solvent. Compared to the coating effect of a single substance, the combined coating of these substances can soften the medicinal properties of the sulfur while providing a good sustained-release effect. The resulting product has a lower sensitization rate and better dispersibility and stability, showing broader application prospects in rinse-off and leave-on products.

[0020] Another object of the present invention is to provide a method for preparing the colloidal sulfur anti-inflammatory and antibacterial agent, the method comprising the following steps:

[0021] S1. Mixing xanthan gum, gum arabic extract, tamarind gum, and sclerotium gum to obtain a coating layer;

[0022] S2. wrapping sulfur with the wrapping layer to obtain an intermediate product;

[0023] S3. Blending the intermediate product with water, and performing jet mill mixing to obtain a colloidal sulfur anti-inflammatory and antibacterial agent.

[0024] Furthermore, in step S1, the stirring and mixing is performed at a rotation speed of 300-500 rpm and for a time of 90-120 min.

[0025] Furthermore, in step S2, the coating method is: adding the coating layer and sulfur into a planetary ball mill, using zirconium oxide as the ball milling medium, and obtaining an intermediate product through ball milling.

[0026] Furthermore, in step S2, the coating method is based on a planetary ball mill mixing process, using zirconia ball milling beads (particle size not exceeding 10 mm) as the milling medium. During the ball milling process, the solid material is subjected to a certain intensity of impact due to the mechanochemical shearing action of the milling medium. On the one hand, the particle size of the solid material can be reduced, facilitating mutual mixing; on the other hand, the shear force between the surfaces of the solid materials produces an interface layer, which is necessary for the mutual diffusion and wetting of the solid materials. Compared with conventional stirring and mixing methods, this method produces the interface layer on the surface of the solid material at a much faster rate, resulting in uniform dispersion of the solid materials, thus achieving the purpose of specific coating.

[0027] Furthermore, in step S3, the intermediate product and the solvent are slurried at a solid-liquid ratio of 1-1.5:1, and then added to a high-pressure jet mill for jet mixing. The flow rate of the high-pressure jet mill is 300-400 m / s and the pressure is 80-100 MPa.

[0028] Another object of the present invention is to provide the use of the colloidal sulfur anti-inflammatory and antibacterial agent in shampoo, shower gel, essence, and cream.

[0029] The present invention has the following beneficial effects:

[0030] The present invention provides a colloidal sulfur anti-inflammatory and antibacterial agent. The colloidal sulfur anti-inflammatory and antibacterial agent comprises a coating layer composed of xanthan gum, gum arabic, tamarind gum and sclerotium gum, and a sulfur core is coated with a specific coating technology to obtain particles with a core-shell structure. The particles are mixed with water and subjected to jet milling treatment to obtain the colloidal sulfur anti-inflammatory and antibacterial agent.

[0031] The colloidal sulfur anti-inflammatory and antibacterial agent of the present invention is a yellow viscous liquid with a slight inherent odor. The active ingredients introduced through the colloidal substance work synergistically with sulfur, and have strong bactericidal and anti-inflammatory, oil-control and acne-removing functions. It can inhibit the growth of bacteria on the skin and has a certain alleviating effect on inflammatory skin diseases such as rosacea and seborrheic dermatitis. It also has better biological affinity and less irritation, and can control sebum secretion and unclog skin pores, thereby slowing down the formation of acne, and has a good therapeutic effect on acne, blackheads, acne and various skin problems.

[0032] At the same time, the present invention uses a mixture of multiple colloidal substances as a shell layer to coat sulfur, which not only improves the hydrophilicity of sulfur, but also reduces the volatility of sulfur and reduces odor. Due to the presence of the shell structure, the effective time of the colloidal sulfur is also greatly extended, and it can exert its effect efficiently and lastingly. In addition, the compounding of multiple specific colloidal substances also has good emulsification, thickening and dispersing effects, so that the particles are dispersed in the product for a long time and stably, and are not easy to agglomerate or precipitate under various conditions. Therefore, it has good application prospects in the fields of cleaning and pharmaceutical products. DETAILED DESCRIPTION

[0033] In order to more clearly illustrate the technical solutions of the present invention, the following examples are given. Unless otherwise stated, the raw materials, reactions and post-processing methods mentioned in the examples are common raw materials on the market and technical methods well known to those skilled in the art.

[0034] The terms "preferred," "preferably," "more preferred," and the like, used herein, refer to embodiments of the invention that may provide certain benefits under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

[0035] It should be understood that, except in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about." Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and appended claims are approximations that may vary depending upon the desired properties to be obtained by the present invention.

[0036] The following raw materials are used in the present invention:

[0037] Sulfur was purchased from Zunyi Jinshan Chemical Plant;

[0038] Xanthan gum was purchased from Jining Tangyi Chemical Co., Ltd. with a molecular weight of 2×10 6 ~20×10 6 , the content of polysaccharide high molecular compounds is greater than 99%;

[0039] Gum arabic extract was purchased from Guangzhou Jinbaolai Biotechnology Co., Ltd. with a molecular weight of 5×10 4 ~20×10 4 ;

[0040] Tamarind seed gum was purchased from Shanghai Yuyu New Material Technology Co., Ltd. with a molecular weight of 7×10 5 ~15×10 6 , the polysaccharide content of sour bean seeds is greater than 99%;

[0041] Sclerotinia gum was purchased from Guangzhou Meiyi Biotechnology Co., Ltd. with a molecular weight of 0.8-1.2 kDa and a scleroglucan content greater than 99%. Example

[0042] A colloidal sulfur anti-inflammatory and antibacterial agent, comprising the following components in parts by mass:

[0043] 45 parts of sulfur

[0044] 4 parts xanthan gum

[0045] 4 parts of acacia gum extract

[0046] 4 parts sour bean seed gum

[0047] 4 parts of sclerotium glue

[0048] 50 parts of deionized water;

[0049] The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent comprises the following steps:

[0050] S1. Mix xanthan gum, acacia gum extract, tamarind gum, and sclerotium gum according to the above-mentioned parts by mass at 500 rpm for 90 min to obtain a coating layer;

[0051] S2, adding the coating layer and sulfur into a planetary ball mill, using zirconium oxide ball milling beads with a particle size of ≤10 mm as the ball milling medium, and ball milling for 60 min to obtain an intermediate product;

[0052] S3. Blending the intermediate product with deionized water and beating the mixture, adding the mixture to a high-pressure jet mill for jet mixing, wherein the flow rate of the high-pressure jet mill is 400 m / s and the pressure is 100 MPa, to obtain a colloidal sulfur anti-inflammatory and antibacterial agent. Example

[0053] A colloidal sulfur anti-inflammatory and antibacterial agent, comprising the following components in parts by mass:

[0054] 50 parts of sulfur

[0055] 5 parts xanthan gum

[0056] 5 parts of acacia gum extract

[0057] 5 parts sour bean seed gum

[0058] 5 parts of Sclerotium glue

[0059] 50 parts of deionized water;

[0060] The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent comprises the following steps:

[0061] S1. Mix xanthan gum, acacia gum extract, tamarind gum, and sclerotium gum according to the above-mentioned parts by mass at 500 rpm for 90 min to obtain a coating layer;

[0062] S2, adding the coating layer and sulfur into a planetary ball mill, using zirconium oxide ball milling beads with a particle size of ≤10 mm as the ball milling medium, and ball milling for 60 min to obtain an intermediate product;

[0063] S3. Blending the intermediate product with deionized water and beating the mixture, adding the mixture to a high-pressure jet mill for jet mixing, wherein the flow rate of the high-pressure jet mill is 400 m / s and the pressure is 100 MPa, to obtain a colloidal sulfur anti-inflammatory and antibacterial agent. Example

[0064] A colloidal sulfur anti-inflammatory and antibacterial agent, comprising the following components in parts by mass:

[0065] 40 parts of sulfur

[0066] 2 parts xanthan gum

[0067] 3 parts of acacia gum extract

[0068] 3 parts sour bean seed gum

[0069] 2 parts of Sclerotium glue

[0070] 50 parts of deionized water;

[0071] The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent comprises the following steps:

[0072] S1. Mix xanthan gum, acacia gum extract, tamarind gum, and sclerotium gum according to the above-mentioned parts by mass at 500 rpm for 90 min to obtain a coating layer;

[0073] S2, adding the coating layer and sulfur into a planetary ball mill, using zirconium oxide ball milling beads with a particle size of ≤10 mm as the ball milling medium, and ball milling for 60 min to obtain an intermediate product;

[0074] S3. Blending the intermediate product with deionized water and beating the mixture, adding the mixture to a high-pressure jet mill for jet mixing, wherein the flow rate of the high-pressure jet mill is 400 m / s and the pressure is 100 MPa, to obtain a colloidal sulfur anti-inflammatory and antibacterial agent.

[0075] Comparative Example 1

[0076] An anti-inflammatory and antibacterial agent. The difference between this comparative example and Example 1 is that the mass of sour bean seed gum is replaced by xanthan gum, and the other ingredients and preparation method are the same as those in Example 1.

[0077] Comparative Example 2

[0078] An anti-inflammatory and antibacterial agent. The difference between this comparative example and Example 1 is that the mass of sclerotium gum is replaced by xanthan gum, and the other ingredients and preparation method are the same as those in Example 1.

[0079] Comparative Example 3

[0080] An anti-inflammatory and antibacterial agent is prepared by physically blending sulfur, xanthan gum, gum arabic extract, tamarind gum, sclerotium gum and deionized water (the mass fractions of each component are the same as those in Example 1), and stirring uniformly to obtain the anti-inflammatory and antibacterial agent.

[0081] Test Case

[0082] The performance tests were performed on the anti-inflammatory and antibacterial agents prepared in the examples and comparative examples.

[0083] Test method:

[0084] Antibacterial performance test: According to the "Technical Specifications for Safety of Cosmetics (2015 Edition)", the total number of colonies in the sample was determined.

[0085] Anti-inflammatory performance test: According to QB / T 2738-2012 "Evaluation method for antibacterial and antifungal effects of daily chemical products", the antibacterial effect of the sample on Malayan bacteria was measured.

[0086] Stability test: Place the sample at different constant temperatures (5°C, 25°C, 48°C) for 3 months, then take it out and observe the changes in the appearance, color and viscosity of the sample.

[0087] Table 1 Performance test results

[0088]

[0089] According to Table 1, it can be concluded that the colloidal sulfur anti-inflammatory and antibacterial agents prepared in Examples 1-3 of the present invention have strong antibacterial and anti-inflammatory abilities and good stability. However, in Comparative Examples 1-2, the components in the wrapping layer are replaced, resulting in reduced performance in various aspects of the product. Comparative Example 3 is obtained by directly blending the components, which is difficult to produce an ideal synergistic effect, and various performances are significantly reduced.

[0090] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations that come within the meaning and range of equivalents of the claims be embraced therein.

[0091] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A colloidal sulfur anti-inflammatory and antibacterial agent, characterized in that, The colloidal sulfur anti-inflammatory and antibacterial agent comprises the following components in parts by mass: Sulfur 40 - 50 parts Xanthan gum 2 - 5 parts Gum arabic extract 2 - 5 parts Tamarind seed gum 2 - 5 parts Scleroglucan 2 - 5 parts Solvent 2. The colloidal sulfur anti-inflammatory and antibacterial agent according to claim 1, wherein The molecular weight of the gum arabic extract is 5×10 4 ~20×10 4 .

3. The colloidal sulfur anti-inflammatory and antibacterial agent according to claim 1, characterized in that, The molecular weight of the xanthan gum is 2×10 6 ~20×10 6 .

4. The colloidal sulfur anti-inflammatory and antibacterial agent according to claim 1, characterized in that, The molecular weight of the tamarind seed gum is 7×10 5 ~15×10 6 .

5. The colloidal sulfur anti-inflammatory and antibacterial agent according to claim 1, wherein, The molecular weight of the scleroglucan is 0.8 - 1.2 kDa.

6. The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent according to any one of claims 1-5, characterized in that, The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent comprises the following steps: S1. Mix xanthan gum, gum arabic extract, tamarind seed gum, and scleroglucan by stirring to obtain a coating layer; S2. Coat sulfur with the coating layer to obtain an intermediate product; S3. Blend the intermediate product and the solvent, and perform jet mill mixing to obtain the colloidal sulfur anti-inflammatory and antibacterial agent.

7. The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent according to claim 6, characterized in that, In step S1, the stirring speed is 300 - 500 rpm, and the time is 90 - 120 min.

8. The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent according to claim 6, characterized in that, In step S2, the coating method is: add the coating layer and sulfur into a planetary ball mill, use zirconia as the ball milling medium, and obtain the intermediate product through ball milling.

9. The preparation method of the colloidal sulfur anti-inflammatory and antibacterial agent according to claim 6, characterized in that, In step S3, slurry the intermediate product and the solvent at a solid-liquid ratio of 1 - 1.5:1, and then add them into a high-pressure jet mill for jet mixing. The flow rate of the high-pressure jet mill is 300 - 400 m / s, and the pressure is 80 - 100 MPa.

10. Application of the colloidal sulfur anti-inflammatory and antibacterial agent according to any one of claims 1 - 5 in shampoo, shower gel, essence, and cream.

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