Cover

A tubular knitted fabric cover with water and oil repellent treatment addresses the issues of air permeability and stretchability in skin disease treatments, enhancing drug retention and patient comfort.

WO2025154444A1PCT designated stage expired Publication Date: 2025-07-24GUNZE LTD
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Patent Information

Application Number
PCT/JP2024/044181
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-01-15
Filing Date
2024-12-13
Publication Date
2025-07-24

AI Technical Summary

Technical Problem

Existing treatments for skin diseases, such as wrap films and bandages, lack air permeability and stretchability, leading to excessive sweating, inhibited movement, and drug migration, thereby reducing the effectiveness of topical medications.

Method used

A cover composed of a tubular knitted fabric with water and oil repellent treatment, ensuring air permeability and stretchability while preventing drug migration.

Benefits of technology

The cover maintains skin health by allowing air permeability and stretchability, reducing sweating and itching, and effectively retaining topical drugs on the affected area.

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Abstract

This cover is configured to cover an affected part of a patient having a skin disease. The cover is composed of a cylindrical knitted material. The knitted material is subjected to water- and oil-repellent processing. The cover is configured to cover the affected part to which ointment has been applied.
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Description

cover

[0001] The present invention relates to a cover, and more particularly to a cover configured to cover an affected area of ​​a patient with a skin disease.

[0002] JP 2012-518099 A (Patent Document 1) discloses a textile product for patients with skin diseases. The textile product includes at least one textile layer having polytetrafluoroethylene (PTFE) fibers. In this textile product, the PTFE fibers are present on at least one surface of the textile layer for the purpose of contacting the patient's skin (see Patent Document 1).

[0003] Special Publication No. 2012-518099

[0004] When treating patients with skin diseases, plastic wrap is sometimes wrapped around the affected area to promote transdermal absorption of topical medication. However, because plastic wrap is not breathable, excessive humidity can occur if the wrap is left wrapped around the patient's affected area for a long period of time. Furthermore, because plastic wrap is not stretchable, movement of the area around the wrap may be hindered. On the other hand, bandages are breathable and stretchable, but when a bandage is wrapped around a patient's affected area, much of the topical medication applied to the affected area transfers to the bandage. As a result, the topical medication may not be fully effective. Patent Document 1 does not disclose a solution to these problems.

[0005] The present invention has been made to solve such problems, and its purpose is to provide a cover configured to cover the affected area of ​​a patient with a skin disease, which is breathable and stretchable, and which can prevent topical medication applied to the affected area from migrating from the affected area to the cover.

[0006] The cover according to the present invention is configured to cover the affected area of ​​a patient with a skin disease. This cover is made of a tubular knitted fabric. The knitted fabric is treated with a water- and oil-repellent finish. This cover is configured to cover the affected area after a topical medication has been applied.

[0007] This cover is made of knitted fabric, which ensures breathability and stretchability. In addition, the knitted fabric is treated with a water- and oil-repellent finish, which prevents liniment applied to the affected area from migrating from the affected area to the cover.

[0008] The affected area covered by the cover may be a part of the patient's upper or lower limb.

[0009] The cover may have a width of 4 cm or more and 27 cm or less when laid flat.

[0010] In the cover, the weight of the knitted fabric is 85 g / m 2 Above, 350g / m 2 It may be the following:

[0011] The cover may be seamless.

[0012] Sewn areas can cause itching in patients with skin diseases. This cover is seamless, so there are no sewn areas, which can prevent itching in patients.

[0013] In the cover, the knitted fabric may be made of a heat-fusible elastic yarn and a yarn other than the heat-fusible elastic yarn, and may have a fray-preventing function.

[0014] According to this cover, the knitted fabric has an anti-fraying function, so that when the cover is cut to a desired length in the longitudinal direction, the knitted fabric can be prevented from fraying.

[0015] The air permeability of the cover measured in accordance with JIS L 1096 is 25 cm 3 / cm 2 The elongation rate measured in accordance with JIS L 1096 may be 50% or more.

[0016] This cover has an air permeability of 25 cm as measured in accordance with JIS L 1096. 3 / cm 2Since the elongation rate measured in accordance with JIS L 1096 is 50% or more, sufficient breathability and stretchability can be ensured.

[0017] According to the present invention, it is possible to provide a cover configured to cover the affected area of ​​a patient with a skin disease, which is breathable and stretchable, and which can prevent topical medication applied to the affected area from migrating from the affected area to the cover.

[0018] FIG. 1 is a diagram for explaining the use of the cover. FIG. 2 is a diagram schematically showing the plan and cross section of the cover. FIG. 3 is a diagram schematically showing a processing device that applies water- and oil-repellent processing to a cover before the water- and oil-repellent processing. FIG. 4 is a diagram showing the results of an evaluation of a drug fabric migration rate. FIG. 5 is a diagram showing the results of an evaluation of breathability. FIG. 6 is a diagram showing the results of an evaluation of stretchability. FIG. 7 is a diagram showing the results of an evaluation of changes in drug action.

[0019] An embodiment according to one aspect of the present invention (hereinafter also referred to as "the present embodiment") will be described in detail below with reference to the drawings. Note that identical or corresponding parts in the drawings are designated by the same reference numerals, and their description will not be repeated. Furthermore, for ease of understanding, each drawing is drawn in a schematic manner with objects appropriately omitted or exaggerated.

[0020] [1. Configuration of the Cover] FIG. 1 is a diagram illustrating the use of the cover 10 according to the present embodiment. Referring to FIG. 1, a patient HU1 with a skin disease such as atopic dermatitis often applies a topical medication to each affected area AF1. The cover 10 is used to promote percutaneous absorption of the topical medication. Specifically, the cover 10 is configured to cover each affected area AF1 to which the topical medication has been applied. The cover 10 covers, for example, the affected areas AF1 present in the upper limb AR1 (e.g., the joints of the upper limb AR1) and the lower limb LE1 (e.g., the joints of the lower limb LE1).

[0021] For example, in treating patient HU1, wrapping plastic wrap around each affected area AF1 to which the ointment has been applied can be considered to promote transdermal absorption of the ointment. However, because plastic wrap is not breathable, excessive humidity can occur if the plastic wrap is left wrapped around each affected area AF1 for a long period of time. This can result in skin maceration, eczema, miliaria, and the like. Furthermore, because plastic wrap is not stretchable, the movement of the upper limb AR1 and lower limb LE1 wrapped in plastic wrap can be hindered. On the other hand, bandages are breathable and stretchable, but when bandages are wrapped around each affected area AF1 of patient HU1, much of the ointment applied to each affected area AF1 transfers to the bandage. As a result, the effectiveness of the ointment can be insufficient.

[0022] FIG. 2 is a diagram schematically illustrating a plan view and a cross section of a cover 10 according to the present embodiment. Referring to FIG. 2, the upper view shows a plan view of the cover 10, and the lower view shows a cross section of the cover 10. The cover 10 is formed of a tubular knit fabric with a through hole HO1 formed inside. The through hole HO1 extends in the longitudinal direction of the cover 10. The cover 10 is stored, for example, rolled up in the longitudinal direction. The cover 10 is cut to the required length depending on the area of ​​the affected area AF1 to be covered by the cover 10. For example, the upper limb AR1 or the lower limb LE1 is passed through the through hole HO1, and the cut cover 10 is attached to the upper limb AR1 or the lower limb LE1. As a result, the affected area AF1 of the patient HU1 is covered by the cover 10.

[0023] The knitted fabric constituting the cover 10 has been treated to be water- and oil-repellent. Examples of water- and oil-repellent treatments include fluorine treatment, silicone treatment, and acrylic treatment. Since the cover 10 is made of knitted fabric, breathability and stretchability can be ensured. Furthermore, since the knitted fabric of the cover 10 has been treated to be water- and oil-repellent, migration of ointment applied to each affected area AF1 from each affected area AF1 to the cover 10 can be prevented.

[0024] The knitted fabric constituting the cover 10 is a rib fabric knitted into a thin flat knit fabric using a circular knitting machine. Because it is knitted using a circular knitting machine, the cover 10 is seamless. Generally, sewn areas cause itching for a patient HU1 with a skin disease. The cover 10 has no sewn areas, which helps prevent itching in the patient HU1.

[0025] The knitted fabric constituting the cover 10 also has a fray prevention function. This knitted fabric is knitted, for example, by plating knitting a heat-fusible elastic yarn and a yarn other than the heat-fusible elastic yarn. An example of the heat-fusible elastic yarn is a low-melting point polyurethane elastic yarn. Furthermore, examples of the yarn other than the heat-fusible elastic yarn are cotton and rayon. In the knitted fabric constituting the cover 10, a heat-setting process is performed on the plating knitted fabric, and the heat-fusible elastic yarn is fused to the yarn other than the heat-fusible elastic yarn, thereby realizing the fray prevention function. Since the knitted fabric of the cover 10 has a fray prevention function, fraying of the knitted fabric can be suppressed when the cover 10 is cut to a desired length in the length direction.

[0026] The width of the cover 10 when laid flat is, for example, 4 cm or more and 27 cm or less, and preferably 5 cm or more and 20 cm or less.

[0027] The weight of the knitted fabric constituting the cover 10 is, for example, 85 g / m 2 Above, 350g / m 2 Preferably, it is 100 g / m or less. 2 Above, 300g / m 2 More preferably, it is 150 g / m or less. 2 Above, 270g / m 2 The following is the result.

[0028] The fineness of the yarns other than the heat-fusible elastic yarn used in the knitted fabric constituting the cover 10 is, for example, 20 to 100 count, preferably 30 to 85 count, and more preferably 38 to 60 count. The fineness of the heat-fusible elastic yarn used in the knitted fabric constituting the cover 10 is, for example, 15 to 160 dtex, preferably 20 to 80 dtex, and more preferably 20 to 40 dtex.

[0029] The density of the knitted fabric constituting the cover 10 is 30 / inch or more and 50 / inch or less, preferably 33 / inch or more and 45 / inch or less, and more preferably 35 / inch or more and 40 / inch or less, in the wales, and 40 / inch or more and 80 / inch or less, preferably 45 / inch or more and 75 / inch or less, and more preferably 45 / inch or more and 70 / inch or less, in the courses.

[0030] The air permeability of the cover 10 is, for example, 25 cm 3 / cm 2 s or more, preferably 35 cm 3 / cm 2 s or more, more preferably 50 cm 3 / cm 2 The breathability of the cover 10 is measured in accordance with JIS L 1096.

[0031] The cover 10 has an elongation percentage of, for example, 50% or more, preferably 70% or more, and more preferably 85% or more. The elongation percentage of the cover 10 is measured in accordance with JIS L 1096.

[0032] [2. Manufacturing Method of Cover] As described above, the knitted fabric constituting the cover 10 is a ribbed fabric knitted into a thin flat knitted fabric by a circular knitting machine. This knitted fabric is knitted, for example, by plating knitting a heat-sealable elastic yarn and a yarn other than the heat-sealable elastic yarn. The knitted plating knitted fabric is then heat-set. This produces the cover 10A before the water / oil repellent treatment.

[0033] FIG. 3 is a schematic diagram showing a processing apparatus 100 that applies a water- and oil-repellent finish to a cover 10A before the water- and oil-repellent finish. Referring to FIG. 3, the processing apparatus 100 applies a water- and oil-repellent finish to the cover 10A before the water- and oil-repellent finish through a padding process, thereby producing a water- and oil-repellent cover 10. The processing apparatus 100 includes a water tank 20, nip rolls 30A and 30B, and a drying device 40. In the processing apparatus 100, the cover 10A is wound up, for example, by a winding roll (not shown). This allows the cover 10A to be transported from an upstream process to a downstream process.

[0034] The water tank 20 is configured to store the machining liquid LI1. The machining liquid LI1 is a solution containing a water- and oil-repellent agent. Examples of the water- and oil-repellent agent include fluorine-based water- and oil-repellent agents, silicone-based water- and oil-repellent agents, and acrylic-based water- and oil-repellent agents. The cover 10A is transported into the machining liquid LI1, thereby immersing the cover 10A in the machining liquid LI1.

[0035] The nip rolls 30A and 30B are disposed opposite each other. The cover 10A is sandwiched between the nip rolls 30A and 30B. The cover 10A is squeezed by being sandwiched between the nip rolls 30A and 30B.

[0036] Drying device 40 includes, for example, a heater and is configured to dry cover 10A. The heating temperature during drying is, for example, 100° C. or higher and 200° C. or lower. By drying cover 10A, cover 10 after the water- and oil-repellent treatment is completed.

[0037] [3. Features] As described above, the cover 10 according to the present embodiment is configured to cover the affected area AF1 of a patient HU1 with a skin disease. The cover 10 is made of a tubular knitted fabric. The knitted fabric is treated with a water- and oil-repellent finish. The cover 10 is configured to cover the affected area AF1 to which a topical medication has been applied. Since the cover 10 is made of a knitted fabric, breathability and stretchability can be ensured. Furthermore, since the cover 10 has a water- and oil-repellent finish, migration of the topical medication applied to the affected area AF1 from the affected area AF1 to the cover 10 can be prevented.

[0038] [4. Other Embodiments] The concept of the above embodiment is not limited to the embodiment described above. Below, examples of other embodiments to which the concept of the above embodiment can be applied will be described.

[0039] <4-1> In the above embodiment, the knitted fabric constituting the cover 10 does not necessarily have to be a ribbed fabric. The knitted fabric constituting the cover 10 may be made of, for example, a knitted fabric.

[0040] <4-2> In the above embodiment, the knitted fabric constituting the cover 10 does not necessarily have to have a fray-preventing function. That is, the knitted fabric constituting the cover 10 may be knitted only with yarns other than the heat-fusible elastic yarns, for example.

[0041] <4-3> In the above embodiment, the knitted fabric constituting the cover 10 does not necessarily have to be knitted on a circular knitting machine. That is, the cover 10 does not necessarily have to be seamless.

[0042] <4-4> In the above embodiment, the parts to which the cover 10 is attached are not limited to the upper limbs AR1 and the lower limbs LE1. For example, the cover 10 may be attached to the abdomen of the patient HU1.

[0043] The above describes exemplary embodiments of the present invention. That is, the detailed description and the accompanying drawings are disclosed for the purpose of illustrative explanation. Therefore, some of the components described in the detailed description and the accompanying drawings may be non-essential components for solving the problems. Therefore, just because these non-essential components are described in the detailed description and the accompanying drawings, it should not be immediately recognized that these non-essential components are essential.

[0044] Furthermore, the above-described embodiments are merely illustrative of the present invention in all respects. Various improvements and modifications to the above-described embodiments are possible within the scope of the present invention. For example, at least a portion of the configuration of any of the embodiments may be combined with at least a portion of the configuration of any of the other embodiments. In other words, when implementing the present invention, specific configurations can be appropriately adopted depending on the embodiment.

[0045] Examples of the present invention will be described below, but the present invention is not limited to the following examples.

[0046] [1. Examples and Comparative Examples] Fabrics for Examples 1 and 2 and Comparative Examples 2 and 3, as well as a wrap film for Comparative Example 1, were prepared. The physical properties of the fabric for Example 1 were as follows. The composition was 100% cotton. The cotton fineness was 40 count. The count was 36.3 / inch in wale and 47.7 / inch in course. The basis weight was 185.9 g / m 2 The fabric of Example 1 was subjected to a water- and oil-repellent treatment. The conditions for the water- and oil-repellent treatment were as follows: NK Guard S-05 (a fluorine-based water- and oil-repellent agent) manufactured by Nicca Chemical Co., Ltd. was used as the chemical. The non-volatile content was approximately 30%. For the water- and oil-repellent treatment, a fluorine compound treatment solution with a chemical concentration of 10% owf, prepared by adding distilled water to NK Guard S-05, was used. The fabric was immersed in the fluorine compound treatment solution, and the fabric that was pulled out was squeezed with a padder. Thereafter, a tenter treatment was carried out in a 120°C environment for 3 minutes to produce a water- and oil-repellent treated fabric.

[0047] The physical properties of the fabric of Example 2 were as follows. The composition was 49.8% rayon, 40.8% cotton, and 9.4% polyurethane. The fineness of the cotton / rayon blended yarn was 55 count. The fineness of the polyurethane was 22 dtex. The count was 39.0 / inch in wale and 67.3 / inch in course. The basis weight was 244.6 g / m 2 The fabric of Example 2 was subjected to a water- and oil-repellent treatment. The conditions for the water- and oil-repellent treatment were the same as those in Example 1.

[0048] The physical properties of the fabric of Comparative Example 2 were similar to those of Example 1. The fabric of Comparative Example 2 was not subjected to a water- and oil-repellent treatment. The physical properties of the fabric of Comparative Example 3 were similar to those of Example 2. The fabric of Comparative Example 2 was not subjected to a water- and oil-repellent treatment.

[0049] [2. Various Evaluations] <2-1. Evaluation of Drug Fabric Transfer Rate> The drug transfer rate to the fabric was evaluated using the following procedure. The liniment used was Hillmild, and the active ingredient was a heparinoid. (1) 0.02 g of the liniment was weighed out while spreading it on a PE (polyethylene) sheet with a 2 cm square application area. (2) A 3 cm square piece of fabric or plastic wrap was attached to the applied area, and a weight was placed on top to tightly attach the fabric or plastic wrap to the liniment. (3) In this state, the sample was placed in the environment inside the garment (32°C x 50% RH) and left to stand for 2 hours. (4) After 2 hours, the fabric and PE sheet were each placed in separate screw tubes, 30 ml of hexane was added, and ultrasonic extraction was performed for 2 hours. (5) The liquid after ultrasonic extraction was analyzed by gas chromatography to quantify the drug components in the liniment. (6) The ratio of the amount of liniment detected from the fabric or plastic wrap to the amount of liniment loaded was used as the drug fabric transfer rate.

[0050] <2-2. Evaluation of breathability and elongation rate> The breathability and elongation rate of each fabric and wrap film were measured in accordance with JIS L 1096.

[0051] 2-3. Evaluation of Changes in Drug Action The following procedure was used to evaluate changes in drug action associated with drug transfer to the fabric. The ointment used was Hillmild, whose active ingredient was a heparinoid. (1) A 2 cm square ointment application area was prepared on the forearm, and 3 cm square test fabrics were prepared. (2) Between bathing and bedtime, the ointment was applied to the application area, and the test fabric was attached over it and secured with surgical tape. (3) The subject went to sleep in this state, and the fabric was removed upon awakening the next day (8-hour application). This was continued for one week. (4) On the third and seventh days, the stratum corneum moisture content of each test site was measured using a stratum corneum moisture meter, and the increase in stratum corneum moisture content from pre-test was evaluated.

[0052] [3. Evaluation Results] Figure 4 shows the results of the drug material migration rate evaluation. As shown in Figure 4, the drug material migration rates of the fabrics of Examples 1 and 2 were equivalent to that of the wrap film (Comparative Example 1), and were far lower than the drug material migration rates of the fabrics of Comparative Examples 2 and 3.

[0053] 5 shows the results of the breathability evaluation. Referring to FIG. 5, the wrap film (Comparative Example 1) had no breathability at all, so the breathability could not be measured. The breathability of each fabric of Examples 1 and 2 was much higher than that of the wrap film (Comparative Example 1).

[0054] Fig. 6 is a diagram showing the results of the stretchability evaluation. As shown in Fig. 6, the stretchability of each of the fabrics of Examples 1 and 2 was much higher than that of the wrap film (Comparative Example 1).

[0055] Figure 7 shows the results of the evaluation of changes in drug action. Referring to Figure 7, the horizontal axis represents the number of days elapsed since the start of the evaluation, and the vertical axis represents the rate of change in stratum corneum moisture content. Transition L1 represents the rate of change in stratum corneum moisture content for Example 1, and transition L2 represents the rate of change in stratum corneum moisture content for Comparative Example 2. Transition L3 represents the rate of change in stratum corneum moisture content in a region where no liniment was applied. As shown in Figure 7, it was confirmed that the effect of the liniment was more sufficient when the fabric of Example 1 was used than when the fabric of Comparative Example 2 was used.

[0056] 10 cover, 20 water tank, 30 nip roll, 40 drying device, 100 processing device, AF1 affected area, AR1 upper limb, HO1 through hole, HU1 patient, L1, L2, L3 transition, LE1 lower limb, LI1 processing fluid.

Claims

1. A cover configured to cover an affected area of a patient having a skin disease, the cover being composed of a tubular knitted fabric, the knitted fabric being subjected to water and oil repellent treatment, and the cover being configured to cover the affected area with an applied medicament.

2. The cover according to claim 1, wherein the affected area is a part of the upper or lower limb of the patient.

3. The cover according to claim 2, having a width of 4 cm or more and 27 cm or less when laid flat.

4. The basis weight of the woven fabric is 85 g / m 2 or more and 350 g / m 2 or less. The cover according to claim 3.

5. The cover according to claim 4, being seamless.

6. The cover according to claim 5, wherein the knitted fabric is composed of a heat-sealing elastic yarn and a yarn other than the heat-sealing elastic yarn and has a fraying prevention function.

7. The air permeability measured in accordance with JIS L 1096 is 25 cm 3 / cm 2 ·s or more, and the elongation rate measured in accordance with JIS L 1096 is 50% or more. The cover according to any one of claims 1 to 6.

Citation Information

Patent Citations

  • Cylindrical body made from knitted fabric, cylindrical body-connected matter, and method for producing them

    JP2011195991A

  • clothing

    WO2016006541A1