Composition based on a silicon sorbent and method of its production

Abstract

The invention relates to chemistry, medicine and pharmacy, namely to an enteral sorbent. A composition based on a silicon sorbent, in which 1 mass fraction of a silicon sorbent in the form of a gel selected from the group of silicon dioxide, polymethylsiloxane polyhydrate, with a particle size of up to 400 µm, comprises from 0.1 to 10 mass fractions of at least one metal compound pre-dissolved in water. A method, in which 1 mass fraction of a silicon sorbent in the form of a gel selected from the group of silicon dioxide, polymethylsiloxane polyhydrate, with a particle size of up to 400 µm, is mixed with 0.1 to 10 mass fractions of at least one metal compound pre-dissolved in water, after which the mixture is subjected to mechanical treatment with a mixer at a frequency from 100 to 3000 rpm or homogenized using a homogenizer at a frequency from 100 to 3000 rpm.

Description

[0001] COMPOSITION AND METHOD OF ITS PRODUCTION

[0002] The invention relates to chemistry, medicine and pharmacy, in particular to the composition of a pharmaceutical composition based on a silicon sorbent and a method of its manufacture, and can be used in various sectors of the national economy, namely, for the purification of wastewater and pharmaceutical preparations for enteral detoxification.

[0003] Traditionally, a class of agents called “sorbents” is used for such purposes.

[0004] There are several types of sorption mechanisms, and accordingly, agents are divided into adsorbents, absorbents and chemosorbents by type of sorption.

[0005] Adsorbents are solid substances that selectively absorb other substances from a gaseous or liquids with their surface layer. Examples are activated carbon, silica gel, aluminum oxide.

[0006] Absorbents are solid or liquid substances that selectively absorb other substances from a gaseous or liquids with their entire volume. A classic example of an absorbent is water, alkali solutions or calcined salt, etc.

[0007] Chemosorbents are substances that absorb other substances from a gaseous or liquid medium with the formation of a chemical compound. An example is low molecular weight polyvinylpyrrolidone or ion exchange resins.

[0008] Interest in the use of sorbents in general in the national economy is associated with the development of mineral extraction and their processing and subsequent purification of ore depending on the raw materials required. Such sorbents began to be used for the purification of gold, platinum, uranium, etc.

[0009] The range of possible applications of sorbents is very wide: purification of groundwater and wastewater, purification of oil, prevention of its spills in water and soil, air purification, ore processing industry, etc.

[0010] Interest in sorbents used for medical purposes has increased sharply since the 80s of the last century. This was preceded by research by Greek scientists who showed that with the help of activated carbon it is possible to effectively remove toxic products that are formed in the body as a result of diseases from the body by purifying the blood.

[0011] Since then, a large number of sorbents have been introduced for medical purposes. Activated carbon is a universal sorbent that is convenient to use, as it is available in the form of tablets, powder and is used in the chemical, food, pharmaceutical industries and medicine. In addition, coal is able to exhibit a detoxification effect in poisoning with mushrooms, plant alkaloids, due to which it is widely used in medical practice (Zozulya I.S., Ivashchenko O.V. Emergency conditions in the most common poisonings. Ukrainian Medical Journal. -N°6(62) XI - XII 2007).

[0012] However, such a sorbent has significant drawbacks:

[0013] Release in the form of tablets is convenient, but it does not allow to obtain the required amount of sorbent in one dose - to achieve a therapeutic effect, it is necessaiy to use doses of 5-15 g, which corresponds to 25-75 tablets and is difficult for the patient.

[0014] Therefore, attempts have been constantly made to improve the organoleptic characteristics of coal and improve compliance for the patient.

[0015] A pharmaceutical composition with activated carbon in the form of granules is known, obtained by sequentially extruding particles of lignocellulose-based activated carbon with an organic binder and subjecting the extruded granules to mechanical treatment before calcination [US5162286 A, IPC: C01B 31 / 12; B01J 20 / 20, publ. 10.11.1992].

[0016] This pharmaceutical composition of granulated charcoal contains an organic binder selected from the group of natural and synthetic fibers and which contains from about 5% to about 30% by weight of the binder material.

[0017] Such a pharmaceutical composition may contain an organic binder selected from the group of natural resins and which consists of wood rosin, rubber rosin and tall oil rosin.

[0018] However, the charcoal in this pharmaceutical composition has a small surface area and is therefore not used internally.

[0019] An enterosorbent consisting of microcrystalline cellulose (MCC) is known from the prior art and is known in Ukraine under the trade name "MCC".

[0020] Its disadvantages are: unpleasant taste, low adsorption activity, insignificant therapeutic effect, discomfort of the gastrointestinal tract (constipation).

[0021] Silicon dioxide powder has certain sorbent properties. There is a drug known that is used under the trade name "Polysorb", which is an inorganic multifunctional enterosorbent based on highly dispersed silicon dioxide. The powder is used to prepare a suspension for oral administration. However, the use of drugs or food additives in powder form is usually associated with greater inconvenience than the use of drugs and food additives in other forms, especially among children, who are most likely to suffer from intoxication syndrome associated with microorganisms.

[0022] A pharmaceutical composition based on silicon dioxide in the form of a composite enterosorbent with hydrolyzed lignin, microcrystalline cellulose and pectin is known, which contains highly dispersed silicon dioxide in the following component ratios, wt.%, in the form of a powder mixture:

[0023] Hydrolyzed lignin 25.0-35.0, Microciystalline cellulose 25.0-35.0, Highly dispersed silicon dioxide 25.0-35.0, Pectin 4.0-6.0

[0024] In addition to silicon dioxide, this enterosorbent contains hydrolyzed lignin and microcrystalline cellulose, which also have adsorption capacity, as well as excipients that serve to obtain a tablet: pectin, starch and calcium or magnesium stearate

[0025] [RU 2234931 C2, MΠEK: A61K 35 / 78; A61K 33 / 00; A61K 47 / 38; A61P 1 / 00, publ. 27.08.2004,

[0026] Bull. No. 24],

[0027] But the use of such a sorbent is ineffective due to the fact that it cannot be used in large quantities for a single therapeutic dose. In addition, such a sorbent cannot be effective in intoxication of non-microorganism origin.

[0028] Also known as an enterosorbent is the product of nonlinear condensation of methylsilicic acid (in the chemical sense - polymethylsiloxane polyhydrate) - the trade name “Enterosgel”, which is produced in the form of a gel [Directory VIDAL. Medicinal products in Russia. - M.: OVPEE - Astra Farm Service, 2000 - S.E-8],

[0029] However, such a product has a number of significant drawbacks, namely: the inability to accurately dose the required therapeutic dose, since it is used in the form of a gel and is dosed with a teaspoon and tablespoon, the inconvenience of storing the package after the first opening, insufficiently good organoleptic properties, which in many patients cause nausea, up to vomiting, which are already symptoms of intoxication.

[0030] In connection with the above, there is a need to obtain new forms of adsorbents based on polymethyl siloxane, which will increase their compliance and improve the convenience of dosing.

[0031] The closest to the claimed invention is a pharmaceutical composition in the form of a / composite enterosorbent based on a silicon (polymethylsiloxane) polymer selected from the group containing methylsilicic acid xerogel or methylsilicic acid hydrogel, which is characterized in that it contains at least one component selected from the group: lactulose, inulin, lignin, fructooligosaccharides, alginic acid in the form of its pharmaceutically acceptable salts, chitosan, pectin, gum, beta-glucan, in an amount of from 0.1 to 10 parts per 1 mass part of methylsilicic acid hydrogel or xerogel [UA 103089 C2, IPC: A61K 31 / 695; A61K 31 / 715; A61K 31 / 7026; A61P 1 / 00; publ.25.05.2012, bulletin No. 10],

[0032] However, such a sorbent, sold under the brand name “Sorbolong” or “LactoBioEnterosgel”, could not fully solve the problem of organoleptic properties and / or increased efficiency during use.

[0033] The prior art also knows a method of obtaining a pharmaceutical composition in which pre-treated coal is activated with phosphoric acid and granulated, which allows giving an oval shape to the particles due to granulation of crushed olive stones soaked in phosphoric acid and carbonization with subsequent washing and drying. The resulting granules up to 5 mm long allow to eliminate unpleasant sensations and microtraumatization of the mucous membrane [US 5162286 A, MPK: CO IB 31 / 12; B01J 20 / 20, publ.10.11.1992].

[0034] However, the carbon in the resulting pharmaceutical composition has a small surface area, and therefore it is not used internally.

[0035] A method for obtaining a pharmaceutical composition is known, which includes heat treatment of nanodispersed carbon in a hydrocarbon medium and activation with water vapor at temperatures of 700-950°C, pneumohydromechanical processing, drying and impregnation of the sorbent with a solution of the initiator in N-vinylpyrrolidone, and before heat treatment, nanodispersed carbon is mixed with a binder 2-3.0% aqueous solution of polyethylene oxide, at a ratio: nanodispersed carbon / binder - 1.0-1.2, extrusion of the plastic mixture, drying of the extrudate and carbonization of the binder in an inert medium at a temperature of not less than 400°C [R.U 2545743 Cl, MPK: A61K 31 / 79; A61K 33 / 44; A61P 1 / 04; B01J 20 / 32; B01J 20 / 28; B01J 20 / 26;B01J 20 / 20; B82B 3 / 00, publ.10.04.2015, bull.N° 10].

[0036] This method requires appropriate technological equipment, which is quite laborious, but it is especially important that the humidity of the mixture is 5%-9%, which can contribute to the development of microorganisms.

[0037] The closest to the claimed invention is a method of obtaining a pharmaceutical composition in the form of a composite enterosorbent with hydrolyzed lignin, microcrystalline cellulose and pectin, which contains highly dispersed silicon dioxide in the ratio of components, wt.%, in the form of a powder mixture by wet granulation, in which hydrolyzed lignin, additionally moistened to a moisture content of 70%, is mixed sequentially with pectin, microcrystalline cellulose and highly dispersed silicon dioxide, dried to a moisture content of 5-9% and, if necessary, tableting is powdered with a mixture of starch and magnesium or calcium stearate. [RU 2234931 C2, MPK: A61K 35 / 78;A61K 33 / 00;A61K 47 / 38;A61P 1 / 00, publ. 27.08.2004, Bull. No. 24].

[0038] However, this method does not allow to improve the organoleptic characteristics and improve compliance for the patient, in addition, the presence of pectin reduces the activity of lignin.

[0039] The invention is based on the task of creating a composition based on silicon sorbent, which would be convenient for oral administration - would have a large surface area and could be used in large quantities for a single therapeutic dose when applied internally or for external use.

[0040] The second task, set as the basis of the invention, is to create a method for manufacturing a pharmaceutical composition based on silicon sorbent as an enteral sorbent, which would be effective and contribute to improving the organoleptic characteristics.

[0041] The problem is solved in that in the composition based on a silica sorbent gel selected from the group of silicon dioxide, polymethylsiloxane polymer, according to the invention, per 1 mass fraction of silicon dioxide or polymethylsiloxane polymer in the form of a hydrogel with a particle size of not more than 400 microns there are from 0.1 to 10 mass fractions of at least one metal compound, preferably selected from the group: aluminum hydroxide, aluminummagnesium hydroxide, magnesium aluminosilicate, aluminum phosphate, zinc oxide, zinc stearate, zinc podolate, zinc sulfate.

[0042] The mixture of silica gel or polymethylsiloxane polymer with an aqueous solution of aluminum compounds may additionally include liquid maltitol, citric acid, sodium citrate, sorbitol, sodium saccharin, xanthan gum, glycerin and prepared water, with the following ratio of components, %:

[0043] Liquid maltitol 30-60

[0044] Citric acid 10-20

[0045] Sodium citrate 5-10

[0046] Sorbitol 5-10

[0047] Sodium saccharin 1-2

[0048] Xanthan gum 1-2 Glycerin 1-2

[0049] Water made up to 100.

[0050] The composition the mixture of silicon sorbent or polymethylsiloxane polymer with an aqueous solution of metal compounds may additionally include: sugar syrup in a ratio of 50- 70% sugar to 50-30% water, where 1 mass fraction of silicon sorbent accounts for from 0.5 to 5 mass fractions of syrup and the same amount of prepared water.

[0051] As a sugar syrup, a syrup obtained from sugar from the group: mannose, fucose, trehalose, xylose, arabinose, ribose, erythrose, maltose, lactulose, in a ratio of 50-70% sugar to 50-30% water, where 1 mass fraction of polymethylsiloxane accounts for from 0.5 to 5 mass fractions of syrup and the same amount of prepared water.

[0052] The mixture of a silica gel or polymethylsiloxane polymer in the form of a hydrogel with an aqueous solution of metal compounds may additionally contain prebiotics selected from the group: inulin, lactiol, beta-glucan, fructooligosaccharides, galactooligosaccharides, pectins, but not limited to, contain probiotics: saccharomyces boulardii, but not limited to, preservatives, ethylparaben, methylparaben, domiphen bromide, bezalkonium chloride, but not limited to, emulsifier polysorbate 80, but not limited to, a fragrance and a flavor corrector of your choice.

[0053] The second task is solved by the fact that in the method of manufacturing a composition based on a silica gel or a polymethylsiloxane polymer in the form of a hydrogel according to the invention, 1 part by mass of a silica gel or a polymethylsiloxane polymer with a particle size of up to 400 microns is mixed with 0.1 to 10 parts of an aqueous solution of at least one metal compound, preferably selected from the group: aluminum hydroxide, aluminum magnesium hydroxide, magnesium aluminosilicate, aluminum phosphate zinc oxide, zinc stearate, zinc pidolate, zinc sulfate, after which the mixture is subjected to mechanical treatment with a mixer at a frequency of from 100 to 3000 revolutions per minute (rpm) or homogenized using a homogenizer at a frequency of from 100 to 3000 rpm.

[0054] To obtain a powder (for use in the form of powder, capsules ortablets), the resulting mixture is subjected to heat treatment at a temperature of 45° C to 150° C until a powder with a residual moisture content of not more than 50% is obtained. For encapsulation, a powder with a residual moisture content of not more than 2% is used, for tableting, no more than 5%. Powder with a different moisture content can be used for sachets with subsequent preparation of a suspension when dissolved in water, for external use alone or as part of soft forms (ointments, gels, creams, etc.). To the resulting mixture of silica gel or polymethylsiloxane hydrogel with an aqueous solution of metal compounds, with constant stirring in the range from 50 rpm to 500 rpm, sugar syrup can be added in a ratio of 50-70% sugar to 50-30% water, where 1 mass fraction of polymethyl siloxane accounts for 0.5 to 5 mass parts of syrup and the same amount of prepared water until a thick, homogeneous white mixture is obtained.

[0055] As a sugar syrup, a syrup obtained from sugar from the group: mannose, trehalose, xylose, arabinose, ribose, erythrose, maltose, lactulose, fucose in a ratio of 50-70% sugar to 50-30% water can be chosen, where 1 mass fraction of polymethylsiloxane accounts for from 0.5 to 5 mass parts of syrup and the same amount of prepared water.

[0056] To the mixture of silicon sorbent in the form of hydrogel with an aqueous solution of metal compounds with constant stirring in the range from 50 rpm to 500 rpm, from 30% to 60% liquid maltitol, from 10% to 20% citric acid, from 5% to 10% sodium citrate, from 5% to 10% sorbitol, from 1% to 2% sodium saccharin, from 1% to 2% xanthan gum, from 1% to 2% glycerin and water prepared to 100%.

[0057] This form of pharmaceutical composition based on silicon sorbent, obtained according to the claimed method, provides a sufficient therapeutic effect, which is even better than the therapeutic effect of traditional forms of polymethyl siloxane in the form of a paste or hydrogel or powder xerogel, but has much better organoleptic properties, is easily dosed, can be used by children, is simple to perform and economically justified.

[0058] As the experiments show, the result according to the invention provides a more pronounced therapeutic effect.

[0059] Composition Examples

[0060] Example 1. The composition in the preferred embodiment contains per 100 ml:

[0061] Polymethylsiloxane polyhydrate in the form of a hydrogel - 33.3 g

[0062] Aqueous solution (gel) of Aluminum hydroxide - 33.3 g

[0063] Sugar syrup - 50 ml

[0064] Methylparaben - 1.5 mg

[0065] Natamycin - 1.5 mg

[0066] Purified prepared water - up to 100 ml

[0067] Example 2. Silicon dioxide gel - 33.3 g

[0068] Aqueous solution (gel) of Aluminum hydroxide - 33.3 g

[0069] Sugar syrup - 50 ml

[0070] Methylparaben - 1.5 mg

[0071] Natamycin - 1.5 mg

[0072] Purified prepared water - up to 100 ml

[0073] Example of the method of preparation.

[0074] The method of obtaining the composition in the preferred embodiment includes the following steps:

[0075] Dissolving 333 g of aluminum hydroxide in 5000 ml of water preheated to a temperature of 50°-90°C with constant stirring until a gelatinous gel is obtained.

[0076] Adding 333 g of polymethylsiloxane polyhydrate in the form of a hydrogel with a particle size of up to 400 μm to 5000 ml of the hydroxide gel solution while stirring in a mixer with paddle stirrers, starting from a mode of 100 rpm, gradually increasing the mixing speed to 1000 rpm until a homogeneous white mass is obtained.

[0077] Dissolve 15 mg of methylparaben and 15 mg of natamycin in 500 ml of prepared water.

[0078] The solution of paraben and natamycin is added to the sugar syrup and mixed with the previously obtained mass of polymethylsiloxane and aluminum compounds with constant stirring at 100 rpm for at least 10 minutes.

[0079] The resulting white homogeneous syrup mass is poured into consumer packaging

[0080] Method for obtaining powder (xerogel) of polymethylsiloxane with aluminum compounds.

[0081] Dissolving 333 g of aluminum hydroxide (or other aluminum compound) in 5000 ml of water, preheated to a temperature of 50° -90° C, with constant stirring until a gelatinous gel is obtained

[0082] Adding to 5000 ml of aluminum hydroxide gel 333 g of polymethylsiloxane polyhydrate in the form of a hydrogel with a particle size of up to 400 microns while stirring in a mixer with paddle stirrers, starting from a mode of 100 revolutions per minute (rpm), gradually increasing the mixing speed to 1000 rpm until a homogeneous white mass is obtained. The resulting mass is spread on a steel baking sheet and dried at a temperature of 120°C in a dry heat oven with moisture removal. A white amorphous powder is obtained, which can turn into a gel when water is added.

[0083] The powder is either sacheted, encapsulated, or tableted, or used externally on its own (powder or powder), or as part of soft forms (gels, creams, ointments).

[0084] Examples of sorbent effectiveness

[0085] Rotenone intoxication model.

[0086] Rotenone is a complex isoflavonoid without color and odor, which is used as an insecticide, fish poison and broad-spectrum pesticide. In experimental medicine, it is used as a blocker of tissue respiration. It occurs naturally in the seeds and stems of some plants, for example, in Pachyrhizus erosus and in the roots of several members of the legume family. When ingested in a toxic dose in laboratory animals, it can cause blockage of mitochondrial respiration, which causes tissue hypoxia and is manifested by weakness, diarrhea, lateral position of experimental animals, tremors, sometimes convulsions and death. LD50, oral for rats 60 mg / kg - 100 mg / kg is about LD100.

[0087] Rotenone is not dangerous for humans.

[0088] The experiments were performed on outbred male rats weighing 200-240 g. The animals were divided into 8 groups: rotenone, polymethyl siloxane, silicon dioxide, aluminum hydroxide, polymethyl siloxane- Al, polymethyl siloxane-Zn and silicon dioxide-Al or Zn.

[0089] Animals of the 1stexperimental group were orally administered rotenone at a dose of 100 mg / kg via gavage,

[0090] Animals of the 2ndexperimental group were previously orally administered 500 mg / kg of polymethyl siloxane hydrogel (humidity 90%) via gavage 30 min before administration of rotenone at a dose of 100 mg / kg.

[0091] Animals of the 3rdexperimental group, 30 min before the administration of rotenone at a dose of 100 mg / kg, were previously orally administered via a gavage with 500 mg / kg of silicon dioxide gel (humidity 90%).

[0092] Animals of the 4th group, 30 min before the administration of rotenone at a dose of 100 mg / kg, were previously orally administered via a gavage with 500 mg / kg of aluminum hydroxide gel. Animals of the 5thgroup, 30 min before the administration of rotenone at a dose of 100 mg / kg, were previously administered via a gavage with the preparation according to the invention at a dose of 1000 mg / kg, which corresponded to a dose of 500 mg / kg of polymethylsiloxane hydrogel (90% humidity) and 500 mg / kg of aluminum hydroxide.

[0093] Animals of group 6, 30 min before administration of rotenone at a dose of 100 mg / kg, were previously administered via gavage the preparation according to the invention at a dose of 1000 mg / kg, which corresponded to a dose of 500 mg / kg of polymethylsiloxane hydrogel (90% humidity) and 500 mg / kg of zinc stearate.

[0094] Animals of group 7, 30 min before administration of rotenone at a dose of 100 mg / kg, were previously orally administered via gavage the preparation according to the invention at a dose of 1000 mg / kg, which corresponded to a dose of 500 mg / kg of silica gel (90% humidity) and 500 mg / kg of aluminum hydroxide.

[0095] Animals of group 8 were previously orally administered a preparation according to the invention at a dose of 1000 mg / kg 30 min before administration of rotenone at a dose of 100 mg / kg via gavage, which corresponded to a dose of 500 mg / kg of silica gel (90% humidity) and 500 mg / kg of zinc stearate.

[0096] The time to the onset of symptoms and the number of dead animals were assessed.

[0097] In animals of group 1, symptoms of poisoning in the form of motor agitation appeared at 24+Z-2 min, and after 2 hours all animals died.

[0098] In animals of group 2, symptoms of poisoning appeared at 35+ / -3 min, after 2 hours 3 out of 6 animals died, after 2 days 2 animals remained alive.

[0099] In animals of group 3, symptoms of poisoning appeared after 30+ / -5 min, after 2 hours 3 animals out of 6 died, after a day 2 animals also remained alive.

[0100] In animals of group 4, symptoms of poisoning appeared after 30+ / -12 min, after 2 hours 1 animal out of 6 died, after a day 2 animals remained alive.

[0101] In animals of groups 5-8, symptoms of poisoning appeared only after 90+ / -12 min, after 2 hours 1 animal out of 6 died, after a day 5 animals remained alive.

[0102] Thus, it is possible to conclude about the pronounced protective effect of the drug according to the invention, which surpasses the effectiveness of each of the sorbents separately, and the effect of the composition is synergistic. In vitro experiments were also conducted.

[0103] Fig. 1 and Fig. 2 show the activity of the sorbent according to the invention in comparison with silica gel on a model system using Congo red dye (Note: EA is the code of the sorbent obtained according to the invention).

[0104] The graphs clearly show the isotherms of dye sorption by sorbents, which are dosedependent. It is noteworthy that the sorbent according to the Invention at a dose of 500 mg completely decolorized the dye solution by sorbing it, while the reference sorbent silica gel, even at a dose of 1000 mg, was unable to completely decolorize the solution.

[0105] Industrial acceptability

[0106] All substances are available on the market, and it will not be difficult for a specialist pharmacist to perform the appropriate calculations of the doses of components and perform the stages of preparation according to the invention.

[0107] Such a pharmaceutical composition expands the list of sorbents that can be used in medical practice and the national economy.

Claims

FORMULA OF THE INVENTION1. A composition based on a silicon sorbent selected from the group of silicon dioxide, polymethyl siloxane polymer, characterized in that 1 mass fraction of a silicon sorbent in the form of a gel selected from the group of: silicon dioxide, polymethylsiloxane polyhydrate, with a particle size of up to 400 microns contains from 0.1 to 10 mass fractions of at least one metal compound, preferably selected from the group of aluminum hydroxide, aluminummagnesium hydroxide, magnesium aluminosilicate, aluminum phosphate, zinc oxide, zinc stearate, zinc podolate, zinc sulfate pre-dissolved in water.

2. The composition according to claim 1, characterized in that the mixture of silica gel or polymethyl siloxane polymer with an aqueous solution of aluminum compounds includes liquid maltite, citric acid, sodium citrate, sorbitol, sodium saccharin, xanthan gum, glycerin and prepared water, with the following ratio of components, %:Liquid maltitol 30-60Citric acid 10-20Sodium citrate 5-10Sorbitol 5-10Sodium saccharin 1-2Xanthan gum 1-2Glycerin 1-2Water made up to 100.

3. The composition according to claim 1 , characterized in that the mixture of silicon sorbent or polymethyl siloxane polymer with an aqueous solution of metal compounds includes sugar syrup in a ratio of 50-70% sugar to 50-30% water, where 1 mass fraction of silicon sorbent accounts for from 0.5 to 5 mass fractions of syrup and the same amount of prepared water.

4. The composition according to claim 3, characterized in that the sugar syrup is selected as a syrup obtained from sugar from the group: mannose, fucose, trehalose, xylose, arabinose, ribose, erythrose, maltose, lactulose, in a ratio of 50-70% sugar to 50-30% water, where 1 mass fraction of coal accounts for from 0.5 to 5 mass fractions of syrup and the same amount of prepared water.

5. The composition according to any of claims 1-4, characterized in that the mixture of metal with an aqueous solution of a silicon sorbent or polymethylsiloxane polymer additionally contains prebiotics selected from the group: inulin, lactiol, beta-glucan, fructooligosaccharides, galactooligosaccharides, pectins, but not exhaustively, contains probiotics: saccharomyces boulardii, but not exhaustively, preservatives, ethylparaben, methylparaben, domiphen bromide, bezalkonium chloride, but not exhaustively, emulsifier polysorbate 80, but not exhaustively, a fragrance and a flavor corrector of any choice.

6. A method for producing a composition based on a silicon sorbent selected from the group of silicon dioxide, polymethylsiloxane polymer, characterized in that 1 mass fraction of a silicon dioxide gel or a polymethylsiloxane polymer in the form of a hydrogel, with a particle size of up to 400 microns, is mixed with 0.1 to 10 particles of at least one metal compound, preferably selected from the group: aluminum hydroxide, aluminummagnesium hydroxide, magnesium aluminosilicate, aluminum phosphate, zinc oxide, zinc stearate, zinc podolate, zinc sulfate, predissolved in water, after which the mixture is subjected to mechanical treatment with a mixer at a frequency of 100 to 3000 rpm or homogenized using a homogenizer at a frequency of 100 to 3000 rpm.

7. The method according to claim 6, characterized in that sugar syrup is added to the mixture of silicon sorbent with an aqueous solution of metal compounds with constant stirring in the range from 50 rpm to 500 rpm in the ratio of 50-70% sugar to 50-30% water, where 1 mass fraction of silicon sorbent is from 0.5 to 5 mass fractions of syrup and the same amount of prepared water to obtain a thick homogeneous white mixture.

8. The method according to claim 7, characterized in that the sugar syrup selected is a syrup obtained from sugar from the group: mannose, trehalose, xylose, arabinose, ribose, erythrose, maltose, lactulose, fucose in a ratio of 50-70% sugar to 50-30% water, where 1 mass fraction of coal accounts for from 0.5 to 5 mass fractions of syrup and the same amount of prepared water.

9. The method according to claim 6, characterized in that the resulting mixture is subjected to heat treatment at a temperature of from 45°C to 150°C to obtain an amorphous powder with a residual humidity of not more than 50%.