Hemodialysis system

Abstract

A hemodialysis system 100 comprises a hydrogen addition device 1 for adding hydrogen to water; a dialysis-use water generating device 2 for generating dialysis-use water; a dialysate preparation device 3 for mixing a drug with the dialysis-use water to prepare a dialysate; a concentration adjustment device 4 for adjusting the concentration of dissolved hydrogen in the dialysate; and a dialysis device 5 for filtering the blood of a patient using the dialysate.

Description

Hemodialysis System

[0001] The present invention relates to a hemodialysis system.

[0002] In recent years, dialysis treatment using dialysis fluid containing dissolved hydrogen gas has attracted attention. For example, electrolyzed hydrogen water, produced by electrolyzing water, is known to contribute to reducing oxidative stress in patients (see, for example, Patent Document 1 below).

[0003] Japanese Patent Application Laid-Open No. 2015-139475

[0004] In hemodialysis systems, a hydrogen addition device is used to add hydrogen to water to produce a dialysate containing dissolved hydrogen gas. In such systems, it is desirable to operate the dialysate with a desired dissolved hydrogen concentration.

[0005] However, after hydrogen addition, the dissolved hydrogen concentration in the dialysate gradually decreases during the waiting period before treatment begins.The dissolved hydrogen concentration also gradually decreases as the dialysate travels along the path from the hydrogen addition device to the dialysis device.

[0006] Therefore, in dialysis treatment for multiple patients using multiple dialysis machines, the route of supplying the dialysis fluid to each machine is different, which may cause the dissolved hydrogen concentration of the dialysis fluid to vary from machine to machine. If the dissolved hydrogen concentration of the dialysis fluid varies, it becomes difficult to provide treatment tailored to the patient's constitution and symptoms.

[0007] The present invention has been devised in view of the above circumstances, and its main object is to provide a hemodialysis system that can suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid.

[0008] The hemodialysis system of the present invention includes a dialysis water generating device that purifies supplied water to generate dialysis water; a dialysis fluid preparation device that mixes a drug with the dialysis water to prepare dialysis fluid to be used in hemodialysis treatment; a dialysis machine that filters the patient's blood using the dialysis fluid; a hydrogen addition device that adds hydrogen to at least one of the water supplied to the dialysis water generating device, the dialysis water generated by the dialysis water generating device, and the dialysis fluid prepared by the dialysis fluid preparation device; and a concentration adjustment device that adjusts the dissolved hydrogen concentration of the dialysis fluid used by the dialysis machine.

[0009] The hemodialysis system of the present invention has the above-described configuration, and therefore is able to suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid and maintain the dissolved hydrogen concentration at a desired level.

[0010] Fig. 1 is a block diagram showing a schematic configuration of the hemodialysis system of the present invention. Fig. 2 is a diagram showing a detailed configuration of the hydrogen addition apparatus of Fig. 1. Fig. 3 is a block diagram showing a modified example of the hemodialysis system of Fig. 1. Fig. 4 is a block diagram showing another modified example of the hemodialysis system of Fig. 1. Fig. 5 is a block diagram showing a modified example of the hemodialysis system of Fig. 6. Fig. 6 is a block diagram showing a modified example of the hemodialysis system of Fig. 6.

[0011] An embodiment of the present invention will now be described with reference to the drawings. Fig. 1 shows the flow path configuration of a hemodialysis system 100 according to this embodiment. The hemodialysis system 100 of this embodiment includes a hydrogen addition device 1, a dialysis water production device 2, a dialysis solution preparation device 3, a concentration adjustment device 4, and a dialysis device 5.

[0012] The hydrogen addition device 1 adds hydrogen to water supplied to the dialysis water production device 2. The hydrogen addition device 1 of this embodiment is disposed upstream of the dialysis water production device 2. Raw water is supplied to the hydrogen addition device 1.

[0013] Although tap water is generally used as the raw water, other sources such as well water and groundwater can also be used. The raw water is pretreated by softening or other methods before being supplied to the hydrogen addition device 1. The raw water to which hydrogen has been added by the hydrogen addition device 1 is supplied to the dialysis water production device 2 as dissolved hydrogen water.

[0014] 2 shows details of the hydrogenation apparatus 1 of this embodiment. The hydrogenation apparatus 1 includes an electrolytic cell 11 that generates hydrogen gas by electrolyzing supplied raw water, and a control unit 16 that controls the electrolytic cell 11.

[0015] The electrolytic cell 11 has an electrolysis chamber 12 in which electrolysis is carried out, a diaphragm 13 , an anode current collector 14 and a cathode current collector 15 .

[0016] The electrolysis chamber 12 is divided by a diaphragm 13 into an anode chamber 12a on the anode current collector 14 side and a cathode chamber 12b on the cathode current collector 15 side. Raw water is supplied to the anode chamber 12a and the cathode chamber 12b via, for example, a bifurcated flow path (not shown).

[0017] For example, a solid polymer membrane is used as the diaphragm 13. An anode current collector 14 is disposed on one side of the diaphragm 13, and a cathode current collector 15 is disposed on the other side.

[0018] A direct current is supplied to the anode power supply 14 and the cathode power supply 15. The direct current supplied to the anode power supply 14 and the cathode power supply 15 is controlled by a control unit 16.

[0019] The control unit 16 controls each part of the hydrogenation apparatus 1. The control unit 16 has, for example, a CPU (Central Processing Unit) that executes various arithmetic processing, information processing, etc., and a memory that stores programs that control the operation of the CPU and various pieces of information. The various functions of the control unit 16 are realized by the CPU, memory, and programs.

[0020] The control unit 16 feedback-controls the electrolysis voltage applied to the anode power supply 14 and the cathode power supply 15 so that the electrolysis current supplied to the anode power supply 14 and the cathode power supply 15 is a predetermined desired value. For example, if the electrolysis current is excessive, the control unit 16 reduces the voltage, and if the electrolysis current is too small, the control unit 16 increases the voltage. This allows the electrolysis current to be appropriately controlled. The electrolysis current is measured, for example, by a measuring unit provided in a circuit that supplies power to the anode power supply 14 and the cathode power supply 15.

[0021] Of the electrolyzed water electrolyzed in the electrolytic cell 11, the electrolyzed water produced in the cathode chamber 12b is sent as cathode water to the dialysis water production device 2. On the other hand, the electrolyzed water produced in the anode chamber 12a is discharged to the outside of the hydrogen addition device 1 as anode water.

[0022] Water is electrolyzed in the electrolysis chamber 12, whereby oxygen gas is generated in the anode chamber 12a and hydrogen gas is generated in the cathode chamber 12b.

[0023] The oxygen gas generated in the anode chamber 12 a dissolves in the electrolytic water in the anode chamber 12 a , is taken out of the anode chamber 12 a as anode water, and is discharged to the outside of the hydrogen addition apparatus 1 .

[0024] The hydrogen gas generated in the cathode chamber 12b dissolves in the electrolyzed water in the cathode chamber 12b, is extracted from the cathode chamber 12b as cathode water, and is sent to the dialysis water production apparatus 2. That is, the cathode water sent from the cathode chamber 12b to the dialysis water production apparatus 2 is electrolyzed in the cathode chamber 12b and is electrolyzed hydrogen water in which hydrogen gas is dissolved.

[0025] The hydrogenation device 1 may be in a form including the electrolytic cell 11 described above, or may be in a form in which hydrogen gas generated by a chemical reaction between water and magnesium is dissolved in water, or in which pressurized hydrogen gas inside a cylinder or the like is dissolved in water.

[0026] A tank for storing the generated electrolyzed hydrogen water may be provided at or downstream of the hydrogen addition device 1. This configuration makes it possible to supply a large amount of electrolyzed hydrogen water to the dialysis water production device 2 at one time, making it easily suitable for dialysis treatment for a large number of people.

[0027] The dialysis water production device 2 is disposed between the hydrogen addition device 1 and the dialysis solution preparation device 3. The dialysis water production device 2 purifies the water supplied from the hydrogen addition device 1 to produce dialysis water. A reverse osmosis treatment device, for example, can be used to realize such a configuration.

[0028] The reverse osmosis treatment device uses a reverse osmosis membrane to filter the water supplied from the hydrogen addition device 1. The reverse osmosis treatment device includes a reverse osmosis membrane module having a reverse osmosis membrane, and a pump for pressure-feeding the water supplied from the hydrogen addition device 1 to the reverse osmosis membrane module.

[0029] In the hemodialysis system 100, the dialysis water producing device 2 may be a filtration method other than reverse osmosis that satisfies the standards for dialysis water, such as an ion exchange (EDI: Electrodeionization) module.

[0030] Because hydrogen is dissolved in the water supplied from the hydrogen addition device 1, hydrogen is also dissolved in the dialysis water produced by the dialysis water production device 2. In other words, hydrogen water for dialysis is produced by the dialysis water production device 2. The hydrogen water for dialysis produced by the dialysis water production device 2 is supplied to the dialysis solution preparation device 3.

[0031] A tank for storing the generated hydrogen water for dialysis may be provided at or downstream of the dialysis water generator 2. This configuration allows a large amount of hydrogen water for dialysis to be supplied to the dialysis solution preparation device 3 at one time, making it easily suitable for dialysis treatment for a large number of people. The dialysis water generator 2 may also be provided with a pressure reducing valve for degassing the hydrogen gas contained in the dialysis water.

[0032] The dialysis fluid preparation device 3 is disposed between the dialysis water production device 2 and the concentration adjustment device 4. The dialysis fluid preparation device 3 mixes a drug with the hydrogen water for dialysis produced by the dialysis water production device 2 to prepare the dialysis fluid to be used in hemodialysis treatment. The drug to be mixed with the hydrogen water for dialysis may be a liquid or powdered dialysis base agent.

[0033] Since hydrogen is dissolved in the hydrogen water for dialysis supplied from the dialysis water generating device 2, hydrogen is also dissolved in the dialysis fluid prepared by the dialysis fluid preparing device 3.

[0034] A tank for storing the produced dialysis fluid may be provided in the dialysis fluid preparation device 3 or downstream thereof. This configuration makes it possible to supply a large amount of hydrogen water for dialysis to the dialysis device 5 at one time, making it easily suitable for dialysis treatment for a large number of people. The dialysis fluid preparation device 3 may also be provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis fluid.

[0035] The concentration adjusting device 4 is disposed between the dialysis fluid preparation device 3 and the dialysis device 5. The concentration adjusting device 4 may be disposed in the dialysis fluid preparation device 3 or in a tank disposed downstream thereof. Alternatively, the concentration adjusting device 4 may be disposed within the dialysis device 5. The concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis fluid prepared by the dialysis fluid preparation device 3.

[0036] The concentration adjusting device 4 may be disposed between the dialysis water generating device 2 and the dialysis fluid preparation device 3. In this case, the concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis water supplied to the dialysis fluid preparation device 3, thereby adjusting the dissolved hydrogen concentration of the dialysis fluid.

[0037] The concentration adjusting device 4 may be a device for increasing the dissolved hydrogen concentration of the dialysis fluid or a device for decreasing the dissolved hydrogen concentration of the dialysis fluid.

[0038] Examples of devices for increasing the dissolved hydrogen concentration in the dialysis fluid include those having the same configuration as the hydrogen addition device 1. That is, in addition to a configuration including the electrolytic cell 11 shown in Fig. 2 , the concentration adjustment device 4 may be, for example, a device in which hydrogen gas generated by, for example, a chemical reaction between water and magnesium is dissolved in the dialysis fluid, or a device in which hydrogen gas pressurized inside a cylinder or the like is dissolved in the dialysis fluid. In this case, the electrolytic cell 11 or the like constituting the hydrogen addition device 1 may be configured to also serve as at least a part of the concentration adjustment device 4.

[0039] Devices for lowering the dissolved hydrogen concentration of dialysis fluid include those that degas hydrogen gas contained in the dialysis fluid by opening and closing a pressure reducing valve, and those that mix and dilute dialysis fluid containing dissolved hydrogen with dialysis fluid not containing dissolved hydrogen. In the former case, a pressure reducing valve provided in at least one of the dialysis fluid preparation device 3 or the dialysis device 5 may be configured to also function as at least a part of the concentration adjusting device 4. Furthermore, in a case where a pressure reducing valve for degassing hydrogen gas contained in dialysis water is provided in at least one of the dialysis water production device 2 or the dialysis fluid preparation device 3, the pressure reducing valve may also function as at least a part of the concentration adjusting device 4.

[0040] The dialysis fluid whose dissolved hydrogen concentration has been adjusted by the concentration adjusting device 4 is supplied to the dialysis device 5. That is, the concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device 5. This stabilizes the dissolved hydrogen concentration of the dialysis fluid, and dialysis fluid with the desired dissolved hydrogen concentration is supplied to the dialysis device 5.

[0041] The dialysis device 5 filters the patient's blood using the dialysis fluid supplied from the concentration adjusting device 4. This enables dialysis treatment using dialysis fluid containing dissolved hydrogen. The dialysis device 5 includes, for example, a dialyzer (artificial kidney).

[0042] Blood collected from the patient's body is sent to a dialyzer. The dialyzer has a hollow fiber membrane that separates the blood from the dialysate. The hollow fiber membrane purifies the blood by transferring waste products contained in the blood to the dialysate. The blood purified by the dialyzer is returned to the patient's body. In other words, the dialysis machine 5 purifies the blood while circulating it between the patient's body and the dialyzer. The dialysis machine 5 may also be equipped with a pressure reducing valve for degassing hydrogen gas contained in the dialysis fluid.

[0043] In the hemodialysis system 100, the concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysate, thereby suppressing fluctuations in the dissolved hydrogen concentration of the dialysate and making it possible to maintain a desired dissolved hydrogen concentration. This makes it possible to perform dialysis treatment using dialysate with a dissolved hydrogen concentration that suits the patient's constitution and symptoms.

[0044] In the hemodialysis system of the present invention, the hydrogen addition device 1 may be configured to add hydrogen to at least one of the water supplied to the dialysis water production device 2, the dialysis water produced by the dialysis water production device 2, and the dialysis fluid prepared by the dialysis fluid preparation device 3. That is, the hemodialysis system 100 may be modified, for example, as shown below.

[0045] Figure 3 is a block diagram of a hemodialysis system 100A, which is a modification of the hemodialysis system 100 in Figure 1. The configuration of the hemodialysis system 100 described above can be adopted for parts of the hemodialysis system 100A that are not described below.

[0046] In the hemodialysis system 100A, a hydrogen addition device 1 is disposed between a dialysis water production device 2 and a dialysis fluid preparation device 3.

[0047] The dialysis water production device 2 purifies the supplied raw water to produce dialysis water. The dialysis water produced by the dialysis water production device 2 is supplied to the hydrogen addition device 1, where hydrogen is added. This produces hydrogen water for dialysis, which is dialysis water with hydrogen dissolved in it.

[0048] As in the hemodialysis system 100, the dialysate preparation device 3 prepares a dialysate containing dissolved hydrogen, and the concentration adjusting device 4 adjusts the dissolved hydrogen concentration before supplying the dialysate to the dialysis device 5. This makes it possible to suppress fluctuations in the dissolved hydrogen concentration of the dialysate. This makes it possible to perform dialysis treatment using a dialysate with a dissolved hydrogen concentration appropriate for the patient's constitution and symptoms.

[0049] Figure 4 is a block diagram of a hemodialysis system 100B, which is another variation of the hemodialysis system 100 in Figure 1. The configurations of the above-described hemodialysis systems 100 and 100A can be adopted for parts of the hemodialysis system 100B that are not described below.

[0050] In the hemodialysis system 100B, a hydrogen addition device 1 is disposed between the dialysate preparation device 3 and the concentration adjustment device 4.

[0051] The dialysis water generator 2 purifies the supplied raw water to produce dialysis water. The dialysis water produced by the dialysis water generator 2 is supplied to the dialysis solution preparation device 3, which prepares the dialysis solution. The dialysis solution prepared by the dialysis solution preparation device 3 is supplied to the hydrogen addition device 1, where hydrogen is added, thereby producing dialysis solution with dissolved hydrogen.

[0052] As in the hemodialysis system 100, the concentration of dissolved hydrogen is adjusted by the concentration adjusting device 4 and supplied to the dialysis device 5. This makes it possible to suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid, thereby enabling dialysis treatment using dialysis fluid with a dissolved hydrogen concentration appropriate for the patient's constitution and symptoms.

[0053] Figure 5 is a block diagram of a hemodialysis system 100C, which is yet another variation of the hemodialysis system 100 of Figure 1. The configurations of the above-described hemodialysis systems 100, 100A, and 100B can be adopted for parts of the hemodialysis system 100C that are not described below.

[0054] The hemodialysis system 100C differs from the hemodialysis system 100 etc. in that it includes a sensor 6 that measures the dissolved hydrogen concentration of the dialysis fluid used by the dialysis device 5 and a control device 7 that controls the concentration adjustment device 4.

[0055] The sensor 6 is disposed between the concentration adjusting device 4 and the dialysis device 5. The sensor 6 may be disposed inside the concentration adjusting device 4 or inside the dialysis device 5. The sensor 6 measures the dissolved hydrogen concentration of the dialysis fluid supplied to the dialysis device 5 and outputs an electrical signal corresponding to the measured dissolved hydrogen concentration to the control device 7.

[0056] The control device 7 has, for example, a CPU (Central Processing Unit) that executes various types of arithmetic processing, information processing, etc., and a memory that stores programs that control the operation of the CPU and various types of information. The various functions of the control device 7 are realized by the CPU, memory, and programs. The control device 7 and the control unit 16 may be implemented by a CPU or the like that integrates the functions of both the control device 7 and the control unit 16.

[0057] The control device 7 controls the concentration adjusting device 4 based on the electrical signal output from the sensor 6. When the dissolved hydrogen concentration of the dialysis fluid is lower than the target value, the control device 7 controls the concentration adjusting device 4 to increase the dissolved hydrogen concentration. When the dissolved hydrogen concentration of the dialysis fluid is higher than the target value, the control device 7 controls the concentration adjusting device 4 to decrease the dissolved hydrogen concentration. This makes it possible to easily suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid. This also makes it possible to easily perform dialysis treatment using dialysis fluid with a dissolved hydrogen concentration that suits the patient's constitution and symptoms.

[0058] Fig. 6 is a block diagram of a hemodialysis system 100D, which is a modification of the hemodialysis system 100C in Fig. 5. The configuration of the hemodialysis system 100C described above can be adopted for parts of the hemodialysis system 100D that are not described below.

[0059] The hemodialysis system 100D differs from the hemodialysis system 100C in that it includes multiple dialysis machines 5. The hemodialysis system 100D can simultaneously perform dialysis treatment on multiple patients using multiple dialysis machines 5.

[0060] In the hemodialysis system 100D, in order to be able to supply dialysis fluid to a plurality of dialysis machines 5, it is desirable to provide a tank for storing dialysis water between the dialysis water generator 2 and the dialysis fluid preparation machine 3. The tank may be provided between the hydrogen addition machine 1 and the dialysis water generator 2 or between the dialysis fluid preparation machine 3 and the concentration adjustment machine 4.

[0061] Figure 7 is a block diagram of a hemodialysis system 100E, which is a modification of the hemodialysis system 100D in Figure 6. The configuration of the hemodialysis system 100E described above can be adopted for parts of the hemodialysis system 100E that are not described below.

[0062] The hemodialysis system 100E differs from the hemodialysis system 100D in that it includes a concentration adjusting device 4 and a sensor 6 corresponding to each dialysis machine 5. That is, the hemodialysis system 100E includes multiple dialysis machines 5, multiple concentration adjusting devices 4, and multiple sensors 6.

[0063] Each concentration adjusting device 4 adjusts the dissolved hydrogen concentration of the dialysis fluid supplied to the associated dialysis machine 5. Each sensor 6 measures the dissolved hydrogen concentration of the dialysis fluid supplied to the associated dialysis machine 5. The measurement result of each sensor 6 is output to the control device 7 as an electrical signal.

[0064] The control device 7 individually controls the corresponding concentration adjusting device 4 based on the electrical signal output from each sensor 6. That is, the control device 7 controls the corresponding concentration adjusting device 4 so as to achieve a dissolved hydrogen concentration preset for each dialysis device 5. Note that a control device 7 may be provided for each sensor 6.

[0065] In the hemodialysis system 100E, the dissolved hydrogen concentration of the dialysis fluid supplied to each dialysis machine 5 may be the same or may be different for each dialysis machine 5.

[0066] By controlling the dissolved hydrogen concentration of the dialysis fluid supplied to each dialysis device 5 to be the same, the dissolved hydrogen concentration of all dialysis fluid supplied simultaneously to multiple dialysis devices 5 is made uniform, making it possible to easily suppress fluctuations in the dissolved hydrogen concentration of the dialysis fluid for each dialysis device 5.

[0067] By controlling the dissolved hydrogen concentration of the dialysis fluid supplied to each dialysis device 5 to be different for each dialysis device 5, it is possible to easily perform dialysis treatment using dialysis fluid with an individual dissolved hydrogen concentration according to the constitution and symptoms of each patient, even when dialysis treatment is performed on multiple patients at the same time.

[0068] Figure 8 is a block diagram of a hemodialysis system 100F, which is another modification of the hemodialysis system 100D of Figure 6. The configuration of the hemodialysis system 100F described above, such as the hemodialysis system 100D, can be adopted for parts of the hemodialysis system 100F that are not described below.

[0069] The hemodialysis system 100F differs from the hemodialysis system 100D in that it includes multiple different types of concentration adjusters 4A to 4D. The types of the multiple concentration adjusters 4A to 4D used in the hemodialysis system 100F include the above-mentioned device for increasing the dissolved hydrogen concentration of the dialysate and the device for decreasing the dissolved hydrogen concentration of the dialysate. The type of the concentration adjusters 4A to 4D is not particularly limited, but it is preferable that they include one of the above-mentioned devices for increasing the dissolved hydrogen concentration of the dialysate and one of the devices for decreasing the dissolved hydrogen concentration of the dialysate.

[0070] In the hemodialysis system 100F, the control device 7 selects and controls a concentration adjusting device to be operated from among the plurality of concentration adjusting devices 4A to 4D based on the electrical signal output from the sensor 6.

[0071] For example, when it is desired to rapidly increase the dissolved hydrogen concentration of the dialysis fluid, the control device 7 fully operates the concentration adjustment devices 4A and 4B, which include an electrolytic cell 11 and a device that pressurizes hydrogen gas inside a cylinder, etc. On the other hand, when it is desired to rapidly decrease the dissolved hydrogen concentration of the dialysis fluid, the control device 7 fully operates the concentration adjustment devices 4C and 4D, which degas the hydrogen gas and a device that dilutes the dialysis fluid with dissolved hydrogen, etc.

[0072] The different types of concentration adjusters 4A to 4D do not necessarily need to be centrally arranged as shown in Figure 8, but may be individually and dispersedly installed, for example, between the hydrogen addition apparatus 1 and the dialysis water production apparatus 2, or between the dialysis water production apparatus 2 and the dialysis solution preparation apparatus 3. Furthermore, in the configurations of the hemodialysis systems 100A to 100E, each concentration adjuster 4 may be replaced with a different type of concentration adjuster 4A to 4D. Here, each concentration adjuster 4A to 4D may be installed between the hydrogen addition apparatus 1 and the sensor 6. Furthermore, the hydrogen addition apparatus 1 may be configured to serve as part of the concentration adjusters 4A to 4D, or a pressure reducing valve provided in at least one of the dialysis apparatus 5, the dialysis solution preparation apparatus 3, and the dialysis water production apparatus 2 may be configured to serve as part of the concentration adjusters 4A to 4D.

[0073] Furthermore, when it is desired to control the dissolved hydrogen concentration of the dialysis fluid with high precision, the control device 7 operates the concentration adjustment device 4A, which includes an electrolytic cell 11 that can control the amount of hydrogen gas generated by an electrolytic current. Furthermore, when it is desired to finely adjust the dissolved hydrogen concentration of the dialysis fluid, the control device 7 operates the concentration adjustment devices 4A, 4D, which include an electrolytic cell 11 and which dilute the dialysis fluid with dissolved hydrogen.

[0074] In the hemodialysis system 100F, the control device 7 may be configured to determine the priority of the operation of each concentration adjustment device 4A to 4D based on the output from the sensor 6, and to control each concentration adjustment device 4A to 4D based on the priority.

[0075] The priority of the operation of each of the concentration adjusting devices 4A to 4D is determined using a learning model generated in advance by deep learning using artificial intelligence (AI). The learning model is defined by an intermediate layer generated by machine learning, with the output from the sensor 6, i.e., the dissolved hydrogen concentration of the dialysis fluid, as an input layer and the priority of the operation of each of the concentration adjusting devices 4 as an output layer.

[0076] Although the hemodialysis system 100 and the like of the present invention have been described in detail above, the present invention is not limited to the specific embodiments described above and can be modified and implemented in various forms.

[0077] For example, the hemodialysis systems 100 to 100F are preferably provided with an operating device (not shown) for optionally operating the control device 7 or the concentration adjusting device 4. The operating device may be provided in at least one of the dialysis water generating device 2, the dialysis solution preparing device 3, and the dialysis device 5 so that a doctor, nurse, or the like can remotely or closely operate the control device 7 or the concentration adjusting device 4 from near the patient, etc. The operating device is composed of, for example, various buttons, a touch panel, or the like for the doctor, nurse, or the like to input operations.

[0078] [Additional Notes] The present invention includes the following aspects.

[0079] [Aspect 1] A hemodialysis system comprising: a dialysis water generating device that purifies supplied water to generate dialysis water; a dialysis solution preparation device that mixes a drug with the dialysis water to prepare dialysis solution for use in hemodialysis treatment; a dialysis machine that filters a patient's blood using the dialysis solution; a hydrogen addition device that adds hydrogen to at least one of the water supplied to the dialysis water generating device, the dialysis water generated by the dialysis water generating device, and the dialysis solution prepared by the dialysis solution preparation device; and a concentration adjustment device that adjusts the dissolved hydrogen concentration of the dialysis solution used by the dialysis machine. [Aspect 2] The hemodialysis system according to Aspect 1, comprising: a sensor that measures the dissolved hydrogen concentration of the dialysis solution used by the dialysis machine; and a control device that controls the concentration adjustment device based on an output from the sensor. [Aspect 3] The hemodialysis system according to Aspect 2, comprising a plurality of the dialysis machines. [Aspect 4] The hemodialysis system according to Aspect 3, comprising the concentration adjustment device and the sensor corresponding to each dialysis machine. [Invention 5] The hemodialysis system according to Invention 4, wherein the control device controls the concentration adjuster so as to equalize the dissolved hydrogen concentrations of all the dialysates simultaneously supplied to the plurality of dialysis machines. [Invention 6] The hemodialysis system according to Invention 4, wherein the control device controls the concentration adjuster so that the dialysates supplied to each dialysis machine have different dissolved hydrogen concentrations. [Invention 7] The hemodialysis system according to any one of Inventions 1 to 6, wherein the concentration adjuster includes a plurality of concentration adjusters. [Invention 8] The hemodialysis system according to Invention 7, wherein the concentration adjuster includes a sensor that measures the dissolved hydrogen concentration of the dialysate used by the dialysis machine, and a control device that determines a priority order for the operation of each concentration adjuster based on the output from the sensor and controls each concentration adjuster based on the priority order. [Invention 9] The hemodialysis system according to any one of Inventions 1 to 8, wherein the hydrogen addition device includes an electrolytic cell that generates hydrogen gas by electrolyzing supplied water. [Invention 10] The hemodialysis system according to Invention 9, wherein the electrolytic cell can also be used as the concentration adjuster.[Invention 11] The hemodialysis system according to any one of Inventions 1 to 10, wherein at least one of the dialysis water generating apparatus, the dialysis fluid preparation apparatus, and the dialysis device is provided with a pressure reducing valve for degassing hydrogen gas contained in the dialysis water or the dialysis fluid, and the pressure reducing valve is also applicable as the concentration adjusting device. [Invention 12] The hemodialysis system according to any one of Inventions 1 to 11, wherein at least one of the dialysis water generating apparatus, the dialysis fluid preparation apparatus, and the dialysis device is provided with an operating device for optionally operating the control device or the concentration adjusting device.

[0080] 1: Hydrogen addition device 2: Dialysis water production device 3: Dialysis fluid preparation device 4: Concentration adjustment device 5: Dialysis device 6: Sensor 7: Control device 11: Electrolyzer 100: Hemodialysis system 100A: Hemodialysis system 100B: Hemodialysis system 100C: Hemodialysis system 100D: Hemodialysis system 100E: Hemodialysis system 100F: Hemodialysis system

Claims

1. A hemodialysis system, comprising: a dialysis water generation device that purifies supplied water to generate dialysis water; a dialysis solution preparation device that mixes a drug into the dialysis water to prepare a dialysis solution used for hemodialysis treatment; a dialysis device that filters a patient's blood using the dialysis solution; a hydrogen addition device that adds hydrogen to at least any one of the water supplied to the dialysis water generation device, the dialysis water generated by the dialysis water generation device, and the dialysis solution prepared by the dialysis solution preparation device; and a concentration adjustment device for adjusting the dissolved hydrogen concentration of the dialysis solution used by the dialysis device.

2. The hemodialysis system according to claim 1, further comprising: a sensor that measures the dissolved hydrogen concentration of the dialysis solution used by the dialysis device; and a control device that controls the concentration adjustment device based on an output from the sensor.

3. The hemodialysis system according to claim 2, comprising a plurality of the dialysis devices.

4. The hemodialysis system according to claim 3, comprising the concentration adjustment device and the sensor corresponding to each dialysis device.

5. The hemodialysis system according to claim 4, wherein the control device controls the concentration adjustment device so as to equalize the dissolved hydrogen concentration of all the dialysis solutions simultaneously supplied to the plurality of dialysis devices.

6. The hemodialysis system according to claim 4, wherein the control device controls the concentration adjustment device so that the dialysis solutions supplied to each dialysis device have different dissolved hydrogen concentrations.

7. The hemodialysis system according to claim 1, wherein the concentration adjustment device includes a plurality of concentration adjustment devices.

8. The hemodialysis system according to claim 7, further comprising: a sensor that measures the dissolved hydrogen concentration of the dialysis solution used by the dialysis device; and a control device that determines a priority order of operations of each concentration adjustment device based on an output from the sensor and controls each concentration adjustment device based on the priority order.

9. The hemodialysis system according to claim 1, wherein the hydrogen addition device includes an electrolytic cell that generates hydrogen gas by electrolyzing supplied water.

10. The hemodialysis system according to claim 9, wherein the electrolytic cell is also applicable as the concentration adjustment device.

11. In at least any one of the dialysis water production device, the dialysate preparation device, and the dialysis device, a pressure reducing valve for degassing hydrogen gas contained in the dialysis water or the dialysate is provided, and the pressure reducing valve can also be applied as the concentration adjustment device. The hemodialysis system according to claim 1.

12. In at least any one of the dialysis water production device, the dialysate preparation device, and the dialysis device, an operating device for arbitrarily operating the control device or the concentration adjustment device is provided. The hemodialysis system according to any one of claims 2 to 6 or 8.

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