Pre-filled nasal spray device having sealing switch

Abstract

A pre-filled nasal spray device (100), comprising a syringe (110), a nasal spray nozzle (120) and a fixing base (130), wherein the fixing base (130) is mounted on the syringe (110), and the nasal spray nozzle (120) is connected to the fixing base (130), a liquid channel which extends from the internal chamber of the syringe (110) to the nasal spray nozzle (120) through the fixing base (130) being formed in the pre-filled nasal spray device (100). A sealing switch is provided in the liquid channel, and can switch between an open state and a closed state; in the open state, the internal chamber of the syringe (110) is in communication with the outside through the liquid channel; in the closed state, the internal chamber of the syringe (110) is sealed and isolated from the outside. In the pre-filled nasal spray device (100), the sealing switch has a simple structure, and can realize reliable sealing of pre-filled liquid medicine in the pre-filled nasal spray device (100).

Description

Pre-filled nasal spray device with sealed switch Technical Field

[0001] The present application relates to medical devices, and in particular to a nasal spray device for applying medicine into internal cavities of the human body, such as the nasal cavity. In particular, the nasal spray device is a pre-filled nasal spray device. Background Art

[0002] There are various types of spray delivery devices on the market, including prefilled nasal sprays. These devices pre-fill the syringe with a pre-filled medication solution. This eliminates the need to draw medication from a vial or other container when administering the medication to the user's nasal cavity; the solution can be sprayed directly from the syringe. Prefilled nasal sprays are convenient to use, leading to their increasing application.

[0003] Since the liquid medicine to be applied to the user is pre-filled in the pre-filled nasal spray device, the sealing requirements for the pre-filled nasal spray device are particularly high to ensure the quality of the liquid medicine contained in the pre-filled nasal spray device.

[0004] In other words, the sealing performance of a prefilled nasal spray device is crucial to the quality of the liquid medicine contained within. Poor sealing can lead to leakage and evaporation of the liquid medicine contained within the device, reducing the amount of medicine available for subsequent administration. Furthermore, the liquid medicine can come into contact with the external environment, leading to contamination, oxidation, and deterioration. This reduced drug volume can affect the efficacy of the drug, while contamination and oxidation not only compromise its efficacy but also pose a safety risk to drug use.

[0005] Therefore, strict control is required during the design and production of prefilled nasal spray devices to ensure that their sealing performance can meet the highest standards.

[0006] The sealing structure of existing pre-filled nasal spray devices usually adopts a protective cap seal, that is, a protective cap is added to the pre-filled nasal spray device to isolate the interior of the pre-filled nasal spray device from the outside world. Common protective caps include bayonet-type protective caps and Luer-type protective caps. The disadvantage of the bayonet-type protective cap is that its seal is unreliable and it is easy to slip off the pre-filled nasal spray device, resulting in seal failure. The installation of the Luer-type protective cap requires relatively high professional skills and requires personnel with rich practical experience. It should neither be tightened too loosely nor too tightly. If it is tightened too loosely, the required seal cannot be achieved, but if it is tightened too tightly, the Luer connection structure between the protective cap and the pre-filled nasal spray device will easily slip off.

[0007] Therefore, there is a need for further improving the structure of the pre-filled nasal spray device, which can achieve reliable sealing on the pre-filled nasal spray device with a simple structure. Summary of the Invention

[0008] The present application is made to solve the problems existing in the prior art mentioned above. The purpose of the present application is to provide a pre-filled nasal spray device with an improved structure, which includes a sealing switch with a simple structure and can achieve reliable sealing of the pre-filled nasal spray device.

[0009] The present application provides a prefilled nasal spray device comprising a syringe, a nasal spray nozzle, and a mounting base, wherein the mounting base is mounted on the syringe and the nasal spray nozzle is connected to the mounting base. A liquid passage is formed in the prefilled nasal spray device, extending from an internal chamber of the syringe through the mounting base to the nasal spray nozzle. A sealing switch is provided in the liquid passage, capable of switching between an open state and a closed state. In the open state, the inner cavity of the syringe communicates with the outside world via the liquid passage, and in the closed state, the inner cavity of the syringe is sealed and isolated from the outside world.

[0010] In the pre-filled nasal spray device, the sealing switch has a simple structure and can achieve reliable sealing of the pre-filled liquid medicine in the pre-filled nasal spray device.

[0011] In a specific structure, the sealing switch includes a sealing plug, and a sealing surface is formed on the front end of the fixing seat or the needle seat of the syringe, and the sealing plug can form a sealing fit with the sealing surface.

[0012] More specifically, the nasal spray head can move between a closed position and an open position relative to the fixing seat along the axial direction of the pre-filled nasal spray device. In the closed position, the nasal spray head presses the sealing plug against the sealing surface. In the open position, the nasal spray head releases the pressure on the sealing plug.

[0013] Preferably, the mounting base includes a guide rail portion, the top surface of which includes a lowered surface and an elevated surface. The outer surface of the nasal nozzle outer sleeve of the nasal nozzle is formed with at least one slider, which rests on the top surface of the guide rail portion. The nasal nozzle is rotatable relative to the mounting base so that the slider contacts the lowered surface and the elevated surface, respectively. When the slider contacts the lowered surface, the nasal nozzle is in a closed position relative to the mounting base, and when the slider contacts the elevated surface, the nasal nozzle is in an open position relative to the mounting base.

[0014] In such a structure, the sealing switch can be easily opened and closed by rotating the nasal spray head relative to the fixing base.

[0015] Alternatively, in another structure, the nasal spray head is configured to be able to move linearly between a closed position and an open position along the axial direction of the pre-filled nasal spray device relative to the fixing seat.

[0016] Preferably, the sealing surface is a tapered inner surface formed at the front end of the fixing seat or in the needle seat of the syringe. The tapered inner surface helps to improve the sealing performance between the sealing plug and the sealing surface.

[0017] In another specific configuration, the sealed switch includes an opening, and the sealed switch is movable between a closed position and an open position, wherein the opening is closed in the closed position and the opening is open in the open position.

[0018] An exemplary embodiment of the opening is at least one side hole formed at the front end of the fixing seat.

[0019] Preferably, the nasal spray nozzle includes an inner sleeve, the inner diameter of which is smaller than the outer diameter of the front end portion of the fixing base where the side holes are formed, so that the front end portion where the side holes are formed has an interference fit with the inner sleeve, and at least one guide groove is formed in the inner sleeve. The nasal spray nozzle is rotatable relative to the fixing base between a closed position and an open position. In the closed position, the side holes are offset from the guide groove, and in the open position, the side holes are aligned with the guide groove.

[0020] In addition, preferably, the nasal spray nozzle includes an inner sleeve of the nasal spray nozzle, wherein a large inner diameter portion and a small inner diameter portion are formed in the inner sleeve of the nasal spray nozzle, wherein the inner diameter of the small inner diameter portion is smaller than the outer diameter of the portion of the front end of the fixing seat where the side hole is formed, so that the portion of the front end of the fixing seat where the side hole is formed forms an interference fit with the small inner diameter portion, while the inner diameter of the large inner diameter portion is larger than the outer diameter of the portion of the front end of the fixing seat where the side hole is formed. The nasal spray nozzle is capable of linearly moving along the axial direction of the pre-filled nasal spray device relative to the fixing seat between a closed position and an open position. In the closed position, the portion of the front end of the fixing seat where the side hole is formed forms an interference fit with the small inner diameter portion, and in the open position, the portion of the front end of the fixing seat where the side hole is formed is within the large inner diameter portion.

[0021] Further preferably, a groove is formed in the nasal spray head and a peripheral flange is formed on the fixing seat. When the nasal spray head is connected to the fixing seat, the peripheral flange fits in the groove, wherein the width of the groove is greater than the width of the peripheral flange, thereby allowing the nasal spray head to move linearly relative to the fixing seat.

[0022] In another specific embodiment, the sealed switch comprises a knob including a stem, and the opening is a through-hole formed in the stem. A transverse hole is formed in the fixing base, extending perpendicularly to the axis of the prefilled nasal spray device, and the stem is inserted into the transverse hole of the fixing base. The knob is rotatable between a closed position and an open position. In the closed position, the through-hole is offset from the longitudinal channel of the fixing base, and in the open position, the through-hole is aligned with the longitudinal channel.

[0023] The sealing switch can be easily opened and closed by rotating the knob.

[0024] Preferably, a finger grip plate is integrally formed on or connected to the nasal spray nozzle or the fixing base.

[0025] Further preferably, a stopper is provided between the finger plate and the flange on the rear end of the syringe, which can prevent the syringe from moving forward relative to the holder or the nasal spray nozzle during storage and transportation.

[0026] Alternatively, at least one frangible member may be provided between the finger plate and the flange on the rear end of the syringe. In use, by pushing the syringe forward, the frangible member may rupture under the thrust, thereby allowing the syringe to move forward. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] The specific embodiments of the present invention can be more clearly understood from the structures shown in the accompanying drawings, wherein:

[0028] FIG1 shows a cross-sectional view of a prefilled nasal spray device according to a first embodiment of the present application, wherein the prefilled nasal spray device is in a closed state.

[0029] FIG2 shows another cross-sectional view of the prefilled nasal spray device of the first embodiment, wherein the prefilled nasal spray device is in an open state.

[0030] FIG. 3 a is a partially enlarged view of portion A1 in FIG. 1 .

[0031] FIG3 b is a partial enlarged view of portion B1 in FIG2 .

[0032] FIG. 4 a shows a perspective view of the nasal spray tip of the prefilled nasal spray device of FIG. 1 .

[0033] FIG4 b shows a perspective view of the fixing base of the pre-filled nasal spray device of FIG1 , wherein the fixing base does not have a finger grip plate.

[0034] FIG4c shows a perspective view of the nasal spray head of FIG4a and the fixing base of FIG4b assembled together.

[0035] FIG. 5 shows a cross-sectional view of the sealing plunger in the prefilled nasal spray device of FIG. 1 .

[0036] FIG6 shows a cross-sectional view of another structure of the fixing base, wherein the fixing base is provided with a finger-grip plate.

[0037] FIG7 shows a cross-sectional view of a pre-filled nasal spray device according to a second embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

[0038] FIG8 shows another cross-sectional view of the prefilled nasal spray device according to the second embodiment, wherein the prefilled nasal spray device is in an open state.

[0039] FIG9 a is a partial enlarged view of portion A2 in FIG7 .

[0040] FIG9 b is a partial enlarged view of portion B2 in FIG8 .

[0041] FIG10 shows a cross-sectional view of a pre-filled nasal spray device according to a third embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

[0042] FIG11 shows another cross-sectional view of the prefilled nasal spray device according to the third embodiment, wherein the prefilled nasal spray device is in an open state.

[0043] FIG. 12 a is a partial enlarged view of portion A3 in FIG. 10 .

[0044] FIG12 b is a partial enlarged view of portion B3 in FIG11 .

[0045] FIG13 shows a cross-sectional view of a pre-filled nasal spray device according to a fourth embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

[0046] FIG14 shows another cross-sectional view of the prefilled nasal spray device according to the fourth embodiment, wherein the prefilled nasal spray device is in an open state.

[0047] FIG. 15 a is a partially enlarged view of portion A4 in FIG. 13 .

[0048] FIG15 b is a partial enlarged view of portion B4 in FIG14 .

[0049] FIG16 shows a cross-sectional view of a pre-filled nasal spray device according to a fifth embodiment of the present application, wherein the pre-filled nasal spray device is in a closed state.

[0050] FIG17 shows another cross-sectional view of the prefilled nasal spray device according to the fifth embodiment, wherein the prefilled nasal spray device is in an open state.

[0051] FIG18 a is a partial enlarged view of portion A5 in FIG16 .

[0052] FIG18 b is a partial enlarged view of portion B5 in FIG17 .

[0053] (Explanation of Symbols) 100 Prefilled nasal spray device 110 Syringe 111 Needle holder 120 Nasal spray tip 121 Nasal spray tip outer sleeve 122 Slider 123 Stopper 130 Fixing seat 131 Guide rail 132 Lowered surface 133 Raised surface 134 Conical inner surface 135 Liquid outlet 136 Finger plate 140 Sealing plug 141 Conical outer surface 200 Prefilled nasal spray device 210 Syringe 220 Nasal spray tip 221 Nasal spray tip inner sleeve 222 Guide groove 230 Fixing seat 231 Side hole 300 Prefilled nasal spray device 310 Syringe 320 Nasal spray tip 321 Nasal spray tip inner sleeve 322 Large inner diameter portion 323 Small inner diameter portion 324 Groove 325 Finger plate 330 Fixing seat 331 Side hole 332 Peripheral flange 350, stopper 400, prefilled nasal spray device 410, syringe 420, nasal spray nozzle 421, nasal spray nozzle inner sleeve 422, groove 430, fixing seat 431, raised ring 440, sealing plug 500, prefilled nasal spray device 510, syringe 520, nasal spray nozzle 521, side opening 530, fixing seat 531, transverse hole 532, longitudinal channel 540, knob 541, rod 542, through hole 543, raised ring DETAILED DESCRIPTION

[0054] To facilitate understanding of the present invention, the following detailed description of specific embodiments of the prefilled nasal spray device of the present invention is provided in conjunction with the accompanying drawings. It should be understood that the drawings illustrate only preferred embodiments of the present invention and are not to be construed as limiting the scope of the present invention. Those skilled in the art may make various obvious modifications, variations, and equivalent substitutions to the present invention based on the embodiments shown in the drawings. Furthermore, the technical features of the different embodiments described below may be combined arbitrarily, provided that no inconsistencies exist, and all such combinations fall within the scope of the present invention. In the following description of the prefilled nasal spray device, directional terms such as "front," "rear," "upper," and "lower" are used with reference to the orientation of the prefilled nasal spray device as shown in the drawings. The orientation of the prefilled nasal spray device shown in the drawings refers to the orientation of the prefilled nasal spray device during use. "Front" and "upper" refer to the upper side or end of the prefilled nasal spray device in the drawings, corresponding to the side or end of the prefilled nasal spray device closer to the person to whom the medication is administered during use. "Rear" and "lower" refer to the lower side or end of the prefilled nasal spray device in the drawings, corresponding to the side or end of the prefilled nasal spray device farther from the person to whom the medication is administered during use. <First Embodiment>

[0055] 1 to 6 show the structures of a pre-filled nasal spray device 100 and its components according to the first embodiment of the present application.

[0056] The prefilled nasal spray device 100 includes a syringe 110, a nasal spray nozzle 120, and a mounting base 130. The nasal spray nozzle 120 is connected to the mounting base 130 for relative movement. The specific connection structure will be described in more detail below. The mounting base 130 is fixed to the needle hub 111 of the prefilled nasal spray device 100 at the front end of the syringe 110 via a structure such as a snap. The syringe 110 can be made of glass or plastic, and both are within the scope of this application.

[0057] As shown in the figure, a fluid channel is formed in the pre-filled nasal spray device 100, extending from the inner cavity of the syringe 110 through the fixing seat 130 to the inner cavity of the nasal spray head 120. The liquid medicine pre-filled in the syringe 110 can flow through the fluid channel to the nozzle of the nasal spray head 120 and be sprayed out.

[0058] Figure 4a shows a schematic perspective view of a nasal spray nozzle 120 of the prefilled nasal spray device 100. The exemplary nasal spray nozzle 120 shown in the figure has a three-way structure, to which two nozzles can be connected. However, those skilled in the art will appreciate that the nasal spray nozzle 120 can also be configured as a single-head structure, including only one nozzle, which is also within the scope of this application.

[0059] The nasal spray nozzle 120 includes an outer sleeve 121, with at least one slider 122 formed on its outer surface. Preferably, two sliders 122 are formed on the outer surface of the outer sleeve 121, spaced 180 degrees apart from each other. The outer sleeve 121 of the nasal spray nozzle 120 also preferably includes at least one stopper 123. This stopper 123 cooperates with a guide rail 131 of a mounting base 130, described below, to achieve a relatively movable connection between the nasal spray nozzle 120 and the mounting base 130.

[0060] 4 b shows a schematic perspective view of the fixing base 130 of the pre-filled nasal spray device 100. The fixing base 130 includes a guide rail portion 131 provided on its outer periphery. The guide rail portion 131 has a guide surface located on its top. The guide surface includes a lowered surface 132 and an elevated surface 133.

[0061] Figure 4c shows a perspective view of the assembled nasal spray nozzle 120 and mounting base 130. When assembled, the slider 122 on the nasal spray nozzle 120 rests on the guide surface of the guide rail 131. A stopper 123 is located below the guide rail 131 and engages with the lower surface of the guide rail 131 to prevent the nasal spray nozzle 120 from being separated upward from the mounting base 130.

[0062] Further referring to FIG. 6 , it can be seen that a tapered inner surface 134 is formed at the front end of the fixing base 130. This tapered inner surface 134 is adjacent to a liquid outlet 135 of the fixing base 130. When installed, the liquid outlet 135 can communicate with the hole in the needle hub 111 of the syringe 110. The lower end of the sealing plug 140 (see FIG. 5 ) can sealably engage with the tapered inner surface 134, thereby blocking the liquid outlet 135 and preventing the liquid pre-filled in the syringe 110 from leaking or coming into contact with the external environment. It can be seen that the sealing plug 140 cooperates with the tapered inner surface 134 of the fixing base 130 to form a sealed switch, which is disposed in the aforementioned fluid passage.

[0063] Preferably, in the structure shown in FIG5 , a tapered outer surface 141 is formed at the lower end of the sealing plug 140. The shape of the tapered outer surface 141 is configured to match the tapered inner surface 134 in the fixing seat 130. In this way, when the sealing plug 140 is sealingly fitted on the tapered inner surface 134, a surface seal is formed between the sealing plug 140 and the fixing seat 130, thereby forming a more reliable seal.

[0064] Furthermore, as shown in FIG6 , preferably, a finger grip plate 136 is further provided on the fixing base 130. The finger grip plate 136 is, for example, integrally formed at the lower end (or rear end) of the fixing base 130. Of course, the finger grip plate 136 may also be formed at other suitable locations on the fixing base 130. Furthermore, the finger grip plate 136 may also be formed separately and then attached to a suitable location on the fixing base 130.

[0065] Returning to Figures 1 and 2, and in conjunction with Figures 3a and 3b, the operating principle of the pre-filled nasal spray device 100 of the first embodiment will be described.

[0066] The prefilled nasal spray device 100 shown in FIG1 is in a closed state, in which it can be stored, transported, or otherwise handled. At this point, the slider 122 of the nasal spray tip 120 engages with the lowered surface 132 of the guide rail portion 131 of the mounting base 130. The sealing plug 140 is compressed into the space between the inner sleeve 124 of the nasal spray tip 120 and the upper end of the mounting base 130, with the lower end of the sealing plug 140, such as its tapered outer surface 141, pressing against the tapered inner surface 134. This forms a seal, isolating the prefilled liquid in the syringe 110 from the external environment (see FIG3a).

[0067] When it is necessary to administer liquid medicine to a user, an operator (e.g., a medical practitioner) rotates the nasal spray tip 120 relative to the mounting base 130, causing the slider 122 of the nasal spray tip 120 to slide from the lowered surface 132 to the raised surface 133 on the guide rail 131 of the mounting base 130, thereby causing the nasal spray tip 120 to move axially away from the syringe 110. This releases the axial compressive force applied to the sealing plug 140, thereby achieving the open state shown in FIG2 . At this point, the operator pushes the plunger 112 of the syringe 110. Under the pressure of the liquid medicine, the sealing plug 140 is pushed away from the tapered inner surface 134, thereby opening the sealing switch (see FIG3 b ). The liquid medicine in the syringe 110 can enter the nasal spray tip 120, be ejected through the nozzle of the nasal spray tip 120, and be administered to the user, for example, into their nasal cavity.

[0068] <Second embodiment>

[0069] Figures 7 to 9b illustrate a prefilled nasal spray device 200 according to a second embodiment of the present application. Unless otherwise specified or in conflict, the specific structures described above for the first embodiment also apply to the second embodiment. In the following description, identical structures will not be described in detail, and the structures that differ from the first embodiment will be specifically described.

[0070] Similar to the first embodiment, the prefilled nasal spray device 200 includes a syringe 210, a nasal spray nozzle 220, and a mounting base 230. The mounting base 230 is connected to the needle hub of the syringe 210 via a structure such as a buckle. The nasal spray nozzle 220 and the mounting base 230 are also connected together via a structure such as a buckle, and the nasal spray nozzle 220 can rotate relative to the mounting base 230.

[0071] Figure 7 shows the prefilled nasal spray device 200 in a closed state. Referring to Figure 9a, the front end of the fixing base 230 is formed with at least one side hole 231. In the exemplary structure shown in the figure, two side holes 231 are included, spaced 180 degrees apart from each other. The front end of the fixing base 230 is interference-fitted within the nasal spray nozzle inner sleeve 221 of the nasal spray nozzle 220. Thus, the inner surface of the nasal spray nozzle inner sleeve 221 is in sealing contact with the outer surface of the front end of the fixing base 230, particularly the portion thereof containing the side holes 231, thereby closing the side holes 231.

[0072] Figure 8 shows the prefilled nasal spray device 200 in an open state. Compared to the closed state shown in Figure 7, the nasal spray tip 220 has been rotated relative to the mounting base 230 by a predetermined angle, for example, 180°. Referring to Figure 9b, at least one guide groove 222 is provided on the inner surface of the nasal spray tip inner sleeve 221. For example, in the illustrated structure, the guide groove 222 is spaced 180° apart from each other. At this point, after rotating through the predetermined angle, the guide groove 222 in the nasal spray tip 220 aligns with the side hole 231 in the mounting base 230, thereby opening the side hole 231 and releasing the seal of the prefilled nasal spray device 200.

[0073] It can be seen that in the second embodiment, the inner surface of the inner sleeve 221 of the nasal spray head cooperates with the side hole 231 of the fixing seat 230 to form a sealed switch of the pre-filled nasal spray device 200.

[0074] <Third embodiment>

[0075] Figures 10-12b illustrate a prefilled nasal spray device 300 according to a third embodiment of the present application. Unless otherwise specified or in conflict, the specific structures described above for the first and second embodiments also apply to the third embodiment. In the following description, identical structures will not be described in detail, and the structures that differ from the first and second embodiments will be specifically described.

[0076] Similar to the previous embodiment, the prefilled nasal spray device 300 includes a syringe 310, a nasal spray nozzle 320, and a mounting base 330. The mounting base 330 is connected to the needle hub of the syringe 310 via a snap-fit ​​mechanism. The nasal spray nozzle 320 is connected to the mounting base 330 and is capable of linear motion relative to the mounting base 330 along the axial direction of the prefilled nasal spray device 300.

[0077] Figure 10 shows the pre-filled nasal spray device 300 in a closed state. Further referring to Figure 12a , it can be seen that the front end of the fixing base 330 is formed with at least one side hole 331. The inner surface of the nasal spray nozzle inner sleeve 321 of the nasal spray nozzle 320 is formed in a stepped shape, thereby forming a large inner diameter portion 322 with a larger inner diameter and a small inner diameter portion 323 with a smaller inner diameter within the nasal spray nozzle inner sleeve 321. The large inner diameter portion 322 is located in front of the small inner diameter portion 323.

[0078] The inner diameter of the small inner diameter portion 323 is set to be slightly smaller than the outer diameter of the front end of the fixing seat 330, so that the front end of the fixing seat 330 can be interference fit with the small inner diameter portion 323. In this way, when the front end of the fixing seat 330 is fitted into the small inner diameter portion 323, the side hole 331 can be sealed and closed (Figure 12a).

[0079] The inner diameter of the large inner diameter portion 322 is larger than the outer diameter of the front end of the fixing base 330. Thus, when the front end of the fixing base 330 fits within the large inner diameter portion 322, a gap is created between the front end of the fixing base 330 and the large inner diameter portion 322, thereby opening the side hole 331 ( FIG. 12 b ). Consequently, the liquid medicine prefilled in the syringe 310 can enter the nozzle through the side hole 331 and be ejected.

[0080] Preferably, a groove 324 is formed in the inner sleeve 321 of the nasal spray nozzle, and a peripheral flange 332 is formed on the fixing base 330. When the nasal spray nozzle 320 and the fixing base 330 are assembled together, the peripheral flange 332 can fit into the groove 324. In addition, the width of the peripheral flange 332 is smaller than the width of the groove 324, thereby allowing the nasal spray nozzle 320 to reciprocate axially relative to the fixing base 330.

[0081] Preferably, a finger grip plate 325 is further formed on the nasal nozzle 320 . The finger grip plate 325 may be integrally formed on the nasal nozzle 320 , or may be formed separately and connected to the nasal nozzle 320 .

[0082] Further preferably, the prefilled nasal spray device 300 further includes a stopper clip 350. In the closed state of the prefilled nasal spray device 300 shown in FIG10 , the stopper clip 350 is engaged between the finger grip plate 325 of the nasal spray tip 320 and the flange on the rear end of the syringe 310 to prevent the syringe 310 from moving toward the front end relative to the nasal spray tip 320.

[0083] When the operator administers liquid medicine to the user, the operator removes the stopper 350. The operator then pushes the plunger of the syringe 310 toward the front end. Under the pressure of the liquid medicine in the syringe 310, the syringe 310 and the fixing base 330 connected to the needle seat are pushed forward, causing the front end portion of the fixing base 330 including the syringe 310 to move into the large inner diameter portion 322 of the syringe 310, thereby opening the side hole 331.

[0084] In addition to the retaining clip 350, other structures may be provided to prevent relative forward movement of the syringe 310 during storage and transportation. One possible alternative structure is to provide a breakable member between the finger plate 325 and the rear flange of the syringe 310, such as a spacer ring with a weakened portion connected between the finger plate 325 and the rear flange of the syringe 310. During use, the operator pushes the plunger of the syringe 310 toward the front, thereby pushing the syringe 310 forward. This thrust causes the spacer ring to break or shatter along the weakened portion, thereby allowing the syringe 310 to move forward.

[0085] Furthermore, the easily breakable member may also be a plurality of easily breakable struts arranged along the circumferential direction, and these easily breakable struts are connected between the finger grip plate 325 and the rear end flange of the syringe 310 .

[0086] The easily breakable member may be integrally formed on one of the finger grip plate 325 and the rear end flange of the syringe 310. Alternatively, the easily breakable member may be formed separately and connected between the finger grip plate 325 and the rear end flange of the syringe 310.

[0087] It can be seen that the side hole 331 on the fixing seat 330 cooperates with the large inner diameter portion 322 and the small inner diameter portion 323 on the inner surface of the nasal nozzle inner sleeve 321 of the nasal nozzle 320 to form a sealed switch.

[0088] <Fourth embodiment>

[0089] Figures 13-15b illustrate a prefilled nasal spray device 400 according to a fourth embodiment of the present application. Unless otherwise specified or conflicting, the specific structures described above for the first through third embodiments also apply to the fourth embodiment. In the following description, identical structures will not be described in detail, and the structures that differ from the first through third embodiments will be specifically described.

[0090] In the fourth embodiment, a prefilled nasal spray device 400 includes a syringe 410, a nasal spray nozzle 420, and a mounting base 430. The mounting base 430 is connected to the needle hub of the syringe 410 via a structure such as a snap. The nasal spray nozzle 420 is connected to the mounting base 430 and is capable of moving relative to the mounting base 430 along the axial direction of the prefilled nasal spray device 400. Specifically, as shown in FIG13 , a protruding ring 431 is formed on the outer surface of the mounting base 430, and a groove 422 is formed on the inner surface of the outer sleeve of the nasal spray nozzle 420. The protruding ring 431 fits into the groove 422, and the engagement between the protruding ring 431 and the groove 422 allows relative movement between the nasal spray nozzle 420 and the mounting base 430 along the axial direction of the prefilled nasal spray device 400.

[0091] The prefilled nasal spray device 400 also includes a sealing plug 440, which is located in the space at the front end of the mounting base 430 and can be inserted into the liquid outlet on the needle holder of the syringe 410. As shown in FIG15a, when the prefilled nasal spray device 400 is in the closed state shown in FIG13, the nasal spray tip 420 is positioned rearward relative to the mounting base 430, with the nasal spray tip inner sleeve 421 of the nasal spray tip 420 pressing against the sealing plug 440, thereby maintaining the sealing plug 440 inserted into the liquid outlet of the needle holder of the syringe 410.

[0092] During use, the operator pulls the nasal spray tip 420 forward relative to the mounting base 430 (as indicated by the arrow in FIG14 ), thereby releasing the pressure of the nasal spray tip inner sleeve 421 against the sealing plug 440 (see FIG15 b ). The operator then pushes the plunger of the syringe 410, and the pressure of the liquid medicine in the syringe 410 pushes the sealing plug 440 open, allowing the medicine to be dispensed.

[0093] It can be seen that in the fourth embodiment, the sealing plug 440 cooperates with the nasal nozzle inner sleeve 421 of the nasal nozzle 420 to play the role of a sealing switch.

[0094] <Fifth embodiment>

[0095] Figures 16-18b illustrate a prefilled nasal spray device 500 according to a fifth embodiment of the present application. Unless otherwise specified or in conflict, the specific structures described above for the first through fourth embodiments also apply to the fifth embodiment. In the following description, identical structures will not be described in detail, and the structures that differ from the first through fourth embodiments will be specifically described.

[0096] In the fifth embodiment, a prefilled nasal spray device 500 includes a syringe 510, a nasal spray nozzle 520, and a mounting base 530. The mounting base 530 is connected to the needle hub of the syringe 510, and the nasal spray nozzle 520 is connected to the mounting base 530. The connection between these components can be achieved, for example, using a snap ring and groove structure.

[0097] The prefilled nasal spray device 500 also includes a knob 540, and the fixing base 530 is disposed in the front end of the fixing base 530. Specifically referring to Figures 18a and 18b, the knob 540 includes a stem 541. A transverse hole 531 is formed at the front end of the fixing base 530. The transverse hole 531 extends in a direction substantially perpendicular to the axial direction of the prefilled nasal spray device 500, and the stem 541 is inserted into the transverse hole 531. Furthermore, a side opening 521 is formed in the side of the nasal spray nozzle 520. The stem 541 of the knob 540 can be inserted into the side opening 521 and then into the transverse hole 531 of the fixing base 530.

[0098] 18b, a through hole 542 is formed in the stem 541 of the knob 540. The knob 540 can rotate relative to the fixing base 530 to switch between positions where the through hole 542 is aligned with and offset from the longitudinal channel 532 in the fixing base 530.

[0099] Preferably, as shown in FIG. 18 a and FIG. 18 b , a protruding ring 543 is further formed on the rod portion 541 , which helps to keep the knob 540 inserted into the transverse hole 531 of the fixing seat 530 to prevent it from falling out.

[0100] In the closed state shown in Figures 16 and 18a, the through-hole 542 of the knob 540 is offset from the longitudinal channel 532 in the front end of the fixing base 530, thereby isolating the liquid medicine in the syringe 510 from the external environment. During use, the operator rotates the knob 540 to align the through-hole 542 in the knob 540 with the longitudinal channel 532 in the fixing base 530, as shown in Figure 18b, thereby connecting the interior of the syringe 510 to the external environment, thereby allowing the liquid medicine to be ejected.

[0101] It can be seen that in the fifth embodiment, the knob 540 acts as a sealed switch.

Claims

1. A prefilled nasal spray device comprising a syringe, a nasal spray head, and a fixing base, wherein the fixing base is mounted on the syringe, and the nasal spray head is connected to the fixing base, wherein: The prefilled nasal spray device is formed with a liquid passage from the inner chamber of the syringe through the fixing seat to the nasal spray head, characterized in that: A sealing switch is provided in the liquid channel, and the sealing switch can be switched between an open state and a closed state. In the open state, the inner cavity of the syringe is connected to the outside world via the liquid channel, and in the closed state, the inner cavity of the syringe is sealed and isolated from the outside world.

2. The prefilled nasal spray device according to claim 1, wherein: The sealing switch includes a sealing plug. A sealing surface is formed on the front end of the fixing seat or the needle seat of the syringe. The sealing plug can form a sealing fit with the sealing surface.

3. The prefilled nasal spray device according to claim 2, wherein: The nasal spray nozzle is capable of moving relative to the fixing seat along the axial direction of the pre-filled nasal spray device between a closed position and an open position. In the closed position, the nasal spray nozzle presses the sealing plug against the sealing surface. In the open position, the nasal spray nozzle releases the pressure on the sealing plug.

4. The prefilled nasal spray device according to claim 3, wherein: The fixing seat includes a guide rail portion, and the top surface of the guide rail portion includes a lowered surface and an elevated surface; At least one slider is formed on the outer surface of the outer sleeve of the nasal nozzle, and the slider is placed on the top surface of the guide rail portion; The nasal spray head is capable of rotating relative to the fixing seat so that the slider contacts the lowered surface and the raised surface respectively; when the slider contacts the lowered surface, the nasal spray head is in the closed position relative to the fixing seat; and when the slider contacts the raised surface, the nasal spray head is in the open position relative to the fixing seat.

5. The prefilled nasal spray device according to claim 3, wherein: The nasal spray head is configured to be able to linearly move relative to a fixing seat along the axial direction of the pre-filled nasal spray device between the closed position and the open position.

6. The prefilled nasal spray device according to claim 2, wherein: The sealing surface is a tapered inner surface formed at the front end of the fixing seat or in the needle seat of the syringe.

7. The prefilled nasal spray device according to claim 1, wherein: The sealed switch includes an opening, and the sealed switch is movable between a closed position and an open position, wherein the opening is closed in the closed position and the opening is open in the open position.

8. The prefilled nasal spray device according to claim 7, wherein: The opening is at least one side hole formed at the front end of the fixing seat.

9. The prefilled nasal spray device according to claim 8, wherein: The nasal spray nozzle includes a nasal spray nozzle inner sleeve, the inner diameter of the nasal spray nozzle inner sleeve is set to be smaller than the outer diameter of the portion of the front end of the fixing seat where the side hole is formed, so that the portion of the front end where the side hole is formed has an interference fit with the nasal spray nozzle inner sleeve, and at least one guide groove is formed in the nasal spray nozzle inner sleeve; The nasal spray nozzle is rotatable relative to the fixing seat between the closed position and the open position, wherein in the closed position, the side hole is staggered with the guide groove, and in the open position, the side hole is aligned with the guide groove.

10. The prefilled nasal spray device according to claim 8, wherein: The nasal spray nozzle includes a nasal spray nozzle inner sleeve, wherein a large inner diameter portion and a small inner diameter portion are formed in the nasal spray nozzle inner sleeve, wherein the inner diameter of the small inner diameter portion is smaller than the outer diameter of the portion of the front end of the fixing seat where the side hole is formed, so that the portion of the front end of the fixing seat where the side hole is formed forms an interference fit with the small inner diameter portion, and the inner diameter of the large inner diameter portion is larger than the outer diameter of the portion of the front end of the fixing seat where the side hole is formed; The nasal spray head can move linearly along the axial direction of the prefilled nasal spray device between the closed position and the open position relative to the fixing seat. In the closed position, the portion of the front end of the fixing seat where the side hole is formed is interference fit with the small inner diameter portion. In the open position, the portion of the front end of the fixing seat where the side hole is formed is in the large inner diameter portion.

11. The prefilled nasal spray device according to claim 10, wherein: A groove is formed in the nasal spray head, and a peripheral flange is formed on the fixing seat. When the nasal spray head is connected to the fixing seat, the peripheral flange fits into the groove, wherein the width of the groove is greater than the width of the peripheral flange, thereby allowing the nasal spray head to move linearly relative to the fixing seat.

12. The prefilled nasal spray device according to claim 7, wherein: The sealed switch includes a knob, the knob includes a rod, and the opening is a through hole formed on the rod; A transverse hole is formed in the fixing seat, the transverse hole extending in a direction perpendicular to the axial direction of the prefilled nasal spray device, and the rod is inserted into the transverse hole of the fixing seat; The knob is rotatable between a closed position and an open position. In the closed position, the through hole is staggered with the longitudinal channel of the fixing seat. In the open position, the through hole is aligned with the longitudinal channel.

13. The prefilled nasal spray device according to claim 1, wherein: A finger plate is integrally formed on or connected to the nasal spray nozzle or the fixing seat.

14. The prefilled nasal spray device according to claim 13, wherein: A retaining clip is provided between the finger grip plate and a flange on the rear end of the syringe.

15. The prefilled nasal spray device according to claim 13, wherein: At least one frangible member is disposed between the finger grip plate and a flange on the rear end of the syringe.

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