Cropping systems and field applications of (2,4-dichlorophenoxy) acetic acid analogs

Abstract

This disclosure includes methods for application of pesticidal compounds, compositions, to herbicide tolerant plants in a field environment.

Description

CROPPING SYSTEMS AND FIELD APPLICATIONS OF (2,4-DICHLOROPHENOXY) ACETIC ACID ANALOGSFIELD

[0001] Aspects herein include compositions and agricultural methods for the useful control of unwanted plants (for example weeds). The application of such novel herbicides disclosed herein may be used alone, in various formulations, or together with other agriculturally actives including other herbicides to control weeds in various crops. The control of the weeds in such various crops may include applications of herbicides prior to planting of crops (pre-emergent application) or after the planting of the crop (post-emergent application). In addition, the control may be applicable to crops that are no longer desirable, so that other more desirable crops can be cultivated. This disclosure includes (2,4-Dichlorophenoxy)acetic acid analogs. More specifically, this disclosure relates to (2,4-Dichlorophenoxy)acetic acid analogs, such as esters, amides, aminooxies, linkers, and carbon groups being applied to transgenic crop comprising a 2,4-D resistance gene in a field setting to control weeds in modem cropping systems.CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] The application claims the benefit of U.S. Provisional Application No. 63 / 550,848, filed February 7, 2024, the disclosure of which is hereby incorporated by reference in its entirety herein.REFERENCE TO A SEQUENCE LISTING

[0003] The official copy of the sequence listing is submitted electronically via EFS-Web as an XML formatted sequence listing with a file named “211855-US-PRV-l.xml”, created on January 22, 2025 with a size of 48,341 Bytes, and is filed concurrently with the specification. The sequence listing contained in this XML formatted document is part of the specification and is herein incorporated by reference in its entirety.BACKGROUND

[0004] Protecting crops from undesirable vegetation (for example, weeds) which adversely affect crop growth is a constantly recurring problem in agriculture. To help combat this problem, researchers in the field of synthetic chemistry have produced a variety of chemicals and chemical formulations effective in the control of such unwanted plant growth. Chemicalherbicides of many types have been disclosed in the literature and a large number are in commercial use. However, there remains a need for compositions and methods that are effective in controlling undesirable vegetation, and which demonstrate other physiochemical characteristics that make them easy to formulate and to apply under varying field conditions.

[0005] (2,4-Dichlorophenoxy)acetic acid, also known as 2,4-D, is a known herbicide. Often 2,4-D is used as an herbicide and defoliant. Often 2,4-D is used as a weed killer in cereal crops, pastures, and orchards.

[0006] However, various forms of 2,4-D can often suffer from adverse properties, such as volatility, spray drift, vapor drift, pungent odors, limited stability, limited tank-mixability with other pesticidal actives, and / or limited formulation flexibility.

[0007] Efforts to solve the volatility problem, including preparation of water-soluble salts such as the dimethylamine salt of 2,4-D, have not been totally satisfactory because, upon volatilization of the amine, the herbicide reverts back to its initial acid form, which, in itself under certain unfavorable conditions, has sufficient volatility to cause damage to sensitive crops.

[0008] Conventional 2,4-D ester or 2,4-D dimethylamine formulations applied during the warm summer months can lead to vapor drift from the evaporation of the herbicide from sprayed surfaces and subsequent damage to highly susceptible crops such as tomatoes, cotton, soybeans, sunflowers and grapes. This may occur within hours after the herbicide application.

[0009] Furthermore, conventional 2,4-D ester or conventional 2,4-D dimethylamine formulations can suffer from formulation limitations, such as their ability to be mixed, including tank-mixed, with other actives, such as glyphosate.

[0010] More recently, P.C.T. Patent Application No. PCT / US2023 / 071586, entitled (2,4- DICHLOROPHENOXY) ACETIC ACID ANALOGS, filed on August 3, 2023, which has been incorporated by reference in its entirety, describes novel 2,4-D molecules that can be used as a herbicide.

[0011] A need therefore exists for applying alternate forms of 2,4-D that have reduced volatility, reduced spray drift, reduced volatility drift, reduced odor, improved tank-mixability with other pesticidal actives, or improved formulation flexibility for field applications to crops for use as over the top applications or for cropping systems.SUMMARY

[0012] Disclosed herein are various compounds according to various details or aspects. In an embodiment, the subject disclosure provides for a method for controlling weeds in transgeniccrop plants which contain a 2,4-D resistance gene by treating the broad-leaved weeds, grass weeds and transgenic crop plants with a herbicide composition listed in Table 1 in the form of Compound 1. In some aspects, a second herbicide composition is applied to the transgenic crop plants. Accordingly, the second herbicide composition may be selected from the group of a synthetic auxin type herbicide, an ALS inhibitor herbicide, a triazolopyrimidine sulfonamide herbicide, an imidazolinone herbicide, a pyrimidinyl oxybenzoate herbicide, a sulfonylaminocarbonyl triazolinone herbicide, a sulfonylurea herbicide, a benzoic acid herbicide, an aryl picolinate herbicide, a pyridine carboxylate herbicide, a quinoline carboxylic acid herbicide, an auxin transport inhibitor herbicide, a PPO inhibitor herbicide, a PDS inhibitor herbicide, a glyphosate herbicide, a glufosinate herbicide, a photosystem II herbicide, an HPPD inhibitor herbicide, an ACCase inhibitor herbicide, or any combination thereof. In further aspects, the synthetic auxin type herbicide is selected from the group 2,4-D, 2,4-DB, MCPA, mecoprop, dichlorprop, 2,4, 5-T, triclopyr, chloramben, dicamba, 2,3,6-TBA, tricamba, clopyralid, picloram, quinmerac, quinclorac, benazolin, fenac, IAA, NAA, orthonil and fluroxypyr. In an additional aspect, the second herbicide composition is selected from the group of a synthetic auxin type, acetolactate synthase (ALS) or acetohydroxy acid synthase (AHAS) inhibitors, (e.g., imidazolinones, sulfonylureas, pyrimidinylthiobenzoates, triazolopyrimidines, and sulfonylaminocarbonyltriazolinones), photosystem II inhibitors (e.g., phenylcarbamates, pyridazinones, triazines, triazinones, uracils, amides, ureas, benzothiadiazinones, nitriles, phenylpyridazines), acetyl CoA carboxylase (ACCase) inhibitors, (e.g., aryloxyphenoxypropionates, cyclohexanediones, phenylpyrazolines), synthetic auxins (e.g., benzoic acids, phenoxycarboxylic acids, pyridine carboxylic acids, quinoline carboxylic acids), auxin transport inhibitors (e.g., phthalamates, semicarbazones), photosystem I inhibitors (e.g., bipyridyliums), 5 -enolpyruvylshikimate-3 -phosphate (EPSP) synthase inhibitors (e.g., glyphosate), glutamine synthetase inhibitors (e.g., glufosinate, bialafos), microtubule assembly inhibitors (e.g., benzamides, benzoic acids, dinitroanilines, phosphoramidates, pyridines), mitosis inhibitors (e.g., carbamates), very long chain fatty acid (VLCFA) inhibitors (e.g., acetamides, chloroacetamides, oxyacetamides, tetrazolinones), fatty acid and lipid synthesis inhibitors (e.g., phosphorodithioates, thiocarbamates, benzofuranes, chlorocarbonic acids), protoporphyrinogen oxidase (PPO) inhibitors (e.g., diphenylethers, N-phenylphthalimides, oxadiazoles, oxazolidinediones, phenylpyrazoles, pyrimidindiones, thiadiazoles, triazolinones), carotenoid biosynthesis inhibitors (e.g., clomazone, amitrole, aclonifen), phytoene desaturase (PDS) inhibitors (e.g., amides, anilidex, furanones, phenoxybutan-amides, pyridiazinones,pyridines), 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors (e.g., calli stem ones, isoxazoles, pyrazoles, triketones), cellulose biosynthesis inhibitors (e.g., nitriles, benzamides, quinclorac, triazolocarboxamides), herbicides with multiple modes-of-action such as quinclorac, and unclassified herbicides such as arylaminopropionic acids, difenzoquat, endothall, and organoarsenicals. In another aspect the herbicide composition listed in Table 1 and the second herbicide composition are applied sequentially or concurrently. In a further aspect, the herbicide composition listed in Table 1 and the second herbicide composition are applied at the early postemergence stage, at the late post-emergence stage, at the pre-harvest stage, or at the post-harvest stage. In some aspects, the herbicide composition listed in Table 1 and the second herbicide composition are applied before or after the planting of a seed. In other aspects the seed is planted in the soil within at least 45, 44, 43, 42, 41, 40, 39, 38, 37, 36, 35, 34, 33, 32, 31, 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 days before or after the herbicide is applied. In other aspects, the herbicide composition listed in Table 1 is applied at a time selected from the group consisting of between about the VI to V2 and V3 to V4 stages, before flowering, at flowering, after flowering, and at seed formation. In a further aspect, the transgenic crop plants comprise one of Brassica spp., cotton, soybeans, alfalfa, rice, wheat, and corn. In another aspect, the 2,4-D resistance gene is selected from the group of an aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T or an FT_Tv7 genes or an engineered variant thereof. In a further aspect, the method of controlling weeds in transgenic crop plants, wherein the 2,4-D resistance gene is an aad-12 gene. In an additional aspect, the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from the group consisting of SEQ ID NO: 1 through SEQ ID NO:35 or an engineered variant thereof. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 1. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:2. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:3. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:4. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:5. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:6. In an aspect the2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:7. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:8. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:9. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 10. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 11. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 12. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 13. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 14. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 15. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 16. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 17. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 18. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 19. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:20. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:21. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:22. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:23. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:24. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:25. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ IDNO:26. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:27. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:28. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:29. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:30. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:31. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:32. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:33. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO:34. In an aspect the 2,4-D resistance gene shares at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity to SEQ ID NO: 1. In further aspects, the transgenic crop plants comprise a second herbicide resistance gene. In other aspects, the second herbicide resistance gene is selected from the group consisting of a glyphosate resistance gene, a glufosinate resistance gene, a bromoxynil resistance gene, a ppo resistance gene, an ALS resistance gene, a HPPD resistance gene or any combination thereof. In another aspect the second herbicide resistance gene encodes a polypeptide selected from the group consisting of DGT28, glyphosate resistant 5 -enolpyruvylshikimate-3 -phosphate synthase (EPSPS), glyphosate oxidoreductase (GOX), glyphosate-N-acetyl transferase (GAT) and glyphosate decarboxylase. In some aspects, the weeds are selected from dicot or monocot weeds. As an aspect, the herbicide treatment controls the growth of a herbicide resistant weed selected from the group consisting of: Alopecurus myosuroides, Avena fatua, Avena sterilis, Avena sterilis ludoviciana, Brachiaria plantaginea, Bromus diandrus, Bromus rigidus, Cynosurus echinatus, Digitaria ciliaris, Digitaria ischaemum, Digitaria sanguinalis, Echinochloa colona, Echinochloa crus-galli, Echinochloa oryzicola, Echinochloa phyllopogon, Eleusine indica, Eriochloa punctata, Hordeum glaucum, Hordeum leporinum, Ischaemum rugosum, Leptochloa chinensis, Lolium multiflorum, Lolium perenne, Lolium persicum, Lolium rigidum, Phalaris minor, Phalaris paradoxa, Rottboellia exalta, Setaria faberi, Setaria viridis, Setaria viridis var. robusta-alba schreiber, Setaria viridis var. robusta-purpurea, Snowdenia polystachea, Sorghum halepense, Sorghum Sudanese, Alisma plantago-aquatica, Amaranthus blitoides, Amaranthushybridus, Amaranthus lividus, Amaranthus palmeri, Amaranthus powellii, Amaranthus quitensis, Amaranthus retroflexus, Amaranthus rudis, Amaranthus tuberculatus, Ambrosia artemisiifolia, Ambrosia trifida, Ammania auriculata, Ammania coccinea, Anthemis cotula, Apera spica-venti, Bacopa rotundifolia, Bidens pilosa, Bidens subaltemans, Brassica toumefortii, Bromus tectorum, Camelina microcarpa, Chenopodium album, Chrysanthemum coronarium, Conyza bonariensis, Conyza canadensis, Cuscuta campestris, Cyperus difformis, Damasonium minus, Descurainia sophia, Diplotaxis tenuifolia, Echium plantagineum, Elatine triandra var. pedicellata, Euphorbia heterophylla, Fallopia convolvulus, Fimbristylis miliacea, Galeopsis tetrahit, Galium spurium, Helianthus annuus, Iva xanthifolia, Ixophorus unisetus, Kochia scoparia, Lactuca serriola, Limnocharis flava, Limnophila erecta, Limnophila sessiliflora, Lindemia dubia, Lindemia dubia var. major, Lindemia micrantha, Lindemia procumbens, Mesembryanthemum crystallinum , Monochoria korsakowii, Monochoria vaginalis, Neslia paniculata, Papaver rhoeas, Parthenium hysterophorus, Pentzia suffruticosa, Phalaris minor, Raphanus raphanistrum, Raphanus sativus, Rapistrum rugosum, Rotala indica var. uliginosa, Sagittaria guyanensis, Sagittaria montevidensis, Sagittaria pygmaea, S al sol a ib erica, Scirpus juncoides var. ohwianus, Scirpus mucronatus, Setaria lutescens, Sida spinosa, Sinapis arvensis, Sisymbrium orientale, Sisymbrium thellungii, Solarium ptycanthum, Sonchus asper, Sonchus oleraceus, Sorghum bicolor, Stellaria media, Thlaspi arvense, Xanthium strumarium, Arctotheca calendula, Conyza sumatrensis, Crassocephalum crepidiodes, Cuphea carthagenenis, Epilobium adenocaulon, Erigeron philadelphicus, Landoltia punctata, Lepidium virginicum, Monochoria korsakowii, Poa annua, Solanum americanum, Solanum nigrum, Vulpia bromoides, Youngia japonica, Hydrilla verticillata, Plantago lanceolata, Carduus nutans, Carduus pycnocephalus, Centaurea solstitialis, Cirsium arvense, Commelina diffusa, Convolvulus arvensis, Daucus carota, Digitaria ischaemum, Echinochloa crus-pavonis, Fimbristylis miliacea, Galeopsis tetrahit, Galium spurium, Limnophila erecta, Matricaria perforate, Papaver rhoeas, Ranunculus acris, Soliva sessilis, Sphenoclea zeylanica, Stellaria media, Nassella trichotoma, Stipa neesiana, Agrostis stolonifera, Polygonum aviculare, Alopecurus japonicus, Beckmannia syzigachne, Bromus tectorum, Chloris inflate, Echinochloa erecta, Portulaca oleracea, and Senecio vulgaris. In another aspect the further comprises the additional steps of: a) identifying a herbicide resistant broad-leaved weed or grass weed that is tolerant to at least the second herbicide composition; and b) applying an amount of herbicide composition listed in Table 1 effective to control the herbicide resistant broad-leaved weed or grass weed. In other aspects, at least a second pesticide composition comprising a fungicide, nematicide, bactericide, and / or an insecticide is applied tothe transgenic crop plants. In some aspects, the herbicide composition listed in Table 1 is applied at a rate of between about 200 grams to about 2,000 grams of acid equivalent per hectare (g ae / ha). In further aspects, the herbicide composition listed in Table 1 is applied at a is between about 800 g ae / ha to about 1,200 g ae / ha. In an aspect, the herbicide composition listed in Table 1 is applied to a field of herbicide resistant weeds. In another aspect, the herbicide resistant weeds are tolerant to the herbicides selected from the group of a synthetic auxin type, acetolactate synthase (ALS) or acetohydroxy acid synthase (AHAS) inhibitors, (e.g., imidazolinones, sulfonylureas, pyrimidinylthiobenzoates, triazolopyrimidines, and sulfonylaminocarbonyltriazolinones), photosystem II inhibitors (e.g., phenylcarbamates, pyridazinones, triazines, triazinones, uracils, amides, ureas, benzothiadiazinones, nitriles, phenylpyridazines), acetyl CoA carboxylase (ACCase) inhibitors, (e.g., aryloxyphenoxypropionates, cyclohexanediones, phenylpyrazolines), synthetic auxins (e.g., benzoic acids, phenoxycarboxylic acids, pyridine carboxylic acids, quinoline carboxylic acids), auxin transport inhibitors (e.g., phthalamates, semicarbazones), photosystem I inhibitors (e.g., bipyridyliums), 5 -enolpyruvylshikimate-3 -phosphate (EPSP) synthase inhibitors (e.g., glyphosate), glutamine synthetase inhibitors (e.g., glufosinate, bialafos), microtubule assembly inhibitors (e.g., benzamides, benzoic acids, dinitroanilines, phosphoramidates, pyridines), mitosis inhibitors (e.g., carbamates), very long chain fatty acid (VLCFA) inhibitors (e.g., acetamides, chloroacetamides, oxyacetamides, tetrazolinones), fatty acid and lipid synthesis inhibitors (e.g., phosphorodithioates, thiocarbamates, benzofuranes, chlorocarbonic acids), protoporphyrinogen oxidase (PPO) inhibitors (e.g., diphenylethers, N-phenylphthalimides, oxadiazoles, oxazolidinediones, phenylpyrazoles, pyrimidindiones, thiadiazoles, triazolinones), carotenoid biosynthesis inhibitors (e.g., clomazone, amitrole, aclonifen), phytoene desaturase (PDS) inhibitors (e.g., amides, anilidex, furanones, phenoxybutan-amides, pyridiazinones, pyridines), 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors (e.g., calli stem ones, isoxazoles, pyrazoles, triketones), cellulose biosynthesis inhibitors (e.g., nitriles, benzamides, quinclorac, triazolocarboxamides), herbicides with multiple modes-of-action such as quinclorac, and unclassified herbicides such as arylaminopropionic acids, difenzoquat, endothall, and organoarsenicals.

[0013] In an embodiment, the subject disclosure provides for a cropping system for minimizing the development of a herbicide resistant broad-leaved weed or grass weed in a cropgrowing environment comprising: a) planting in a field a crop plant having tolerance to a first herbicide and a herbicide composition listed in Table 1; b) applying at least a first herbicidetreatment comprising the first herbicide and / or herbicide composition listed in Table 1 to the crop growing environment to control weeds; c) identifying a location in the field infested with weeds resistant to the first herbicide; and d) applying an amount of the herbicide composition listed in Table leffective to control the weeds resistant to the first herbicide. In an embodiment, the subject disclosure provides for a method for minimizing the development of a herbicide resistant weed comprising: rotating a first cropping system in a first growing season with a second cropping system in a subsequent growing season, wherein the first and second cropping systems comprise a cropping system. In an aspect, the crop plant in the first cropping system possesses at least one different herbicide tolerance relative to the crop plant in the second cropping system. In a further aspect, the crop plant in the first cropping system and crop plant in the second cropping system are the same species. In another aspect, the crop plant in the first cropping system and crop plant in the second cropping system are different species.

[0014] In an embodiment, the subject disclosure provides for amethod for controlling a glyphosate tolerant weed in a field comprising: a) planting a transgenic seed in a field comprising a glyphosate tolerant weed or a seed thereof, wherein the seed comprises a transgene conferring glyphosate tolerance and a transgene encoding tolerance to a herbicide composition listed in Table 1; b) growing the seed into a plant; and c) treating the field with an amount of a herbicide composition listed in Table 1 and glyphosate effective to control weed growth of the glyphosate tolerant weed.

[0015] In an embodiment, the subject disclosure provides for a method for controlling weed growth in a field comprising: a) planting a transgenic seed in a field comprising a weed or a seed thereof, wherein the transgenic seed comprises a transgene conferring resistance to a herbicide composition listed in Table 1 and at least a second transgene conferring resistance to a second herbicide compound; b) treating the field with a herbicidally effective amount of herbicide composition listed in Table 1, at least a second herbicide compound, or a mixture thereof; and c) growing the transgenic seed into a plant.

[0016] In an embodiment, the subject disclosure provides for a method of assaying an herbicide tolerance characteristic in a plant comprising (a) treating at least one plant or seed with a herbicidally effective amount of a herbicide composition listed in Table 1; and (b) evaluating one or more properties of the at least one plant treated with the herbicidally effective amount of a herbicide composition listed in Table 1.

[0017] In an embodiment, the subject disclosure provides for a method of controlling undesirable vegetation which comprises contacting the vegetation or the locus thereof with, orapplying to the soil to prevent the emergence of vegetation, a herbicidally effective amount of a herbicide composition listed in Table 1. In an aspect, the compound is applied at a rate of between about 200 grams to about 2,000 grams of acid equivalent per hectare (g ae / ha). In a further aspect, the rate is between about 800 g ae / ha to about 1,200 g ae / ha.

[0018] In an embodiment, the subject disclosure provides for a method of controlling undesirable vegetation in a crop that has been made tolerant or resistant to 2,4- dichlorophenoxyacetic acid, which comprises contacting the vegetation or the locus thereof with a herbicidally effective amount of a compound or applying to the soil to prevent the emergence of vegetation, a herbicidally effective amount of a compound.DETAILED DESCRIPTION

[0019] The aspect disclosed below is not intended to be exhaustive or limit the disclosure to the precise form disclosed in the following detailed description. Rather, the aspects are chosen and described so that others skilled in the art may utilize its teachings.

[0020] While various concepts of the present disclosure are illustrated and described in detail in the figures and the description herein, results in the figures and their description are to be considered as exemplary and not restrictive in character; it being understood that only the illustrative aspects are shown and described and that all changes and modifications that come within the spirit of the disclosure are desired to be protected.DEFINITIONS

[0021] Unless defined otherwise, the scientific and technology nomenclatures have the same meaning as commonly understood by a person of ordinary skill in the art pertaining to this disclosure.

[0022] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “about” refers to a range of values plus or minus 10 percent, e.g., about 1.0 encompasses values from 0.9 to 1.1.

[0023] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “agriculturally active” compound includes any compound that may be of benefit to agriculture, including compounds that either alone or in combination with other compounds inhibit the growth of plants deemed undesirable in a given agricultural setting.

[0024] The examples given in the definitions are generally non-exhaustive and must not be construed as limiting the invention disclosed in this document. It is understood that a substituentshould comply with chemical bonding rules and steric compatibility constraints in relation to the molecule to which it is attached.

[0025] As used herein, the term “alkanes” may be understood to include straight chain, branched, or cyclic, substituted, or unsubstituted hydrocarbons, which comprise one or more carbon-carbon bonds. Elements and groups that can be used to substitute alkanes include, but are not limited to, groups which include oxygen, nitrogen, sulfur, halogen, or metals, the linkage between the hydrocarbon and the substituent may be via a carbon-carbon bond or through an element other than carbon including, but not limited to, oxygen, nitrogen, and sulfur.

[0026] As used herein, the term “alkenes” may be understood to refer to straight chain, branched, or cyclic substituted or unsubstituted hydrocarbons, which include at least one carboncarbon double bond. Elements and groups that can be used to substitute alkenes include, but are not limited to, groups which include oxygen, nitrogen, sulfur, halogen, or metals, the linkage between the hydrocarbon and the substituent may be via a carbon-carbon bond or through an element other than carbon including, but not limited to, oxygen, nitrogen, and sulfur.

[0027] As used herein, the term “alkynes” may be understood to include reference to straight chain or branched or cyclic, substituted, or unsubstituted hydrocarbon, which include at least one carbon-carbon triple bond. Elements and groups that can be used to substitute alkynes include, but are not limited to, groups which include oxygen, nitrogen, sulfur, halogen, or metals, the linkage between the hydrocarbon and the substituent may be via a carbon-carbon bond or through an element other than carbon including, but not limited to, oxygen, nitrogen, and sulfur.

[0028] As used herein, the term “halo” may be understood to refer to one or more of the following elements: fluoro, chloro, bromo, and iodo.

[0029] As used herein, the term “aryl” may be understood to refer to any group comprising at least one aromatic ring. The aromatic ring itself may be substituted or unsubstituted.Elements and groups that can be used to substitute aryls include, but are not limited to, groups which include oxygen, nitrogen, sulfur, halogen, or metals, the linkage between the hydrocarbon and the substituent may be via a carbon-carbon bond or through an element other than carbon including, but not limited to, oxygen, nitrogen, and sulfur.

[0030] As used herein, the term “heteroaryl” may be understood to include two aromatic rings which include in the cyclic structure elements other than carbon, such other elements include, but are not limited to, oxygen, nitrogen, sulfur, and the like. Heteroaryl may include more than one ring structure. Heteroaryls may be substituted or unsubstituted, substituents include, but are not limited to, elements and / or groups which include oxygen, nitrogen, sulfur,halogen, or metals, the linkage between the hydrocarbon and the substituent may be via a carbon-carbon bond or through an element other than carbon including, but not limited to, oxygen, nitrogen, and sulfur.

[0031] Exemplary heteroaryls include, but are not limited to, benzofuranyl, benzoisothiazolyl, benzoisoxazolyl, benzoxazolyl, benzothienyl, benzothiazolyl, cinnolinyl, furanyl, imidazolyl, indazolyl, indolyl, isoindolyl, isoquinolinyl, isothiaz olyl, isoxazolyl, oxadiazolyl, oxazolinyl, oxazolyl, phthalazinyl, pyrazinyl, pyrazolinyl, pyrazolylpyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolinyl, quinoxalinyl, tetrazolyl, thiazolinyl, thiazolyl, thienyl, triazinyl, and triazolyl.

[0032] Saturated heterocycles are ring structures which include one or more elements other than carbon, these elements include, but are not limited to, oxygen, nitrogen, sulfur, and the like. Exemplary saturated heterocycles include, but are not limited to, piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, oxetanyl, tetrahydrofuranyl, tetrahydrothienyl and tetrahydropyranyl.

[0033] Examples of partially unsaturated hetero cycles include, but are not limited to,1,2,3,4-tetrahydro quinolinyl, 4.5-dihydro-oxazolyl. 4,5-dihydro-lH-pyrazolyl, 4,5-dihydro- isoxazolyl, and 2,3-dihydro-l,3,4-oxadiazolyl.

[0034] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “alkyl” refers to any of the following: alkanes, alkenes, or alkynes, which are straight chained, branched, or cyclic, substituted, or unsubstituted; substituents may include, but are not limited to, halogens, aminos, iminos, sulfones, sulfoxides, aryls, heteroaryl, esters, ketones, aldehydes, alcohols, acids, and / or esters. Unless explicitly stated otherwise, any compound capable of existing as an isomer, a stereoisomer, or a tautomer may be used in any of its herbicidally active isoforms, configurations, or tautomers.

[0035] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “AMATA” refers to Amaranthus rudis (common waterhemp).

[0036] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “AMBEL” refers to Ambrosia artemisiifolia (common ragweed).

[0037] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “ABUTH” refers to Abutilon theophrasti (velvetleaf).

[0038] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “ERICA” refers to glyphosate resistant Conyza canadensis (L.) (horseweed).

[0039] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “GLXMA” refers to Glycine max (L.) Merr., (soybean).

[0040] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “DCM” refers to dichloromethane.

[0041] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “EtOAC” refers to ethyl acetate.

[0042] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “DMF” refers to dimethyl formamide.

[0043] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “K2CO3” refers to potassium carbonate.

[0044] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “EDC” refers to l-ethyl-3 -(3 -dimethylaminopropyl) carbodiimide.

[0045] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “DMAP” refers to 4-dimethylaminopyridine.

[0046] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “DIPEA” refers to A A-diisopropylethylamine.

[0047] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “EtiN” refers to triethylamine.

[0048] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “HPLC” refers to high-performance liquid chromatography.

[0049] As used herein, unless explicitly stated otherwise or clearly implied otherwise, the term “LC-MS” refers to liquid chromatography coupled with mass spectrometry.

[0050] As used herein, the modifier “about” used in connection with a quantity is inclusive of the stated value and has the meaning dictated by the context (for example, it includes at least the degree of error associated with the measurement of the particular quantity). When used in the context of a range, the modifier “about” should also be considered as disclosing the range defined by the absolute values of the two endpoints. For example, the range “from about 2 to about 4” also discloses the range “from 2 to 4.”

[0051] As previously stated, this disclosure includes (2,4-Dichlorophenoxy)acetic acid analogs. More specifically, this disclosure relates to (2,4-Dichlorophenoxy)acetic acid analogs(“2,4-D analogs”), such as esters, amides, aminooxies, linkers, and carbon groups.

[0052] Exemplary molecules within the aforementioned formulas according to various aspects may include any of the compounds exemplified below in Table 1.Table 1: Pesticidal Compounds

[0053] Without being limited to any theory, it is believed that various 2,4-D analogs can have improved properties prior to or during application. Then, in the soil or in-planta, the 2,4-D analog can be broken into the active form of 2,4-D acid. Thus, various 2,4-D analogs disclosed herein can benefit from the aforementioned improved properties and yet have an acceptable pesticidal profile. The application of such 2,4-D analogs can provide advantages to cropping systems in farming programs. In such instances the 2,4-D analogs can be applied in an over the top spray formulation to transgenic crops comprising 2,4-D resistance genes. The application of the novel 2,4-D analogs function in unexpected and surprising modalities with the 2,4-D resistance genes to provide novel cropping system solutions for producers.

[0054] Disclosed herein are 2,4-D analogs that can be converted into 2,4-D during or after application. For example, disclosed herein are pesticidal compositions of the following Formula (I):Formula (I) where X is any group that can be converted to a carboxylic acid during or after application, such as in the soil or in-planta. For example, some of the aspects, X may be aminooxy, amides, carbon chains, esters, or linker groups.

[0055] As used herein, herbicide means a compound, e.g., an active ingredient, that kills, controls, or otherwise adversely affects the survival, growth and / or reproduction of plants.

[0056] As used herein, a herbicidally effective or vegetation controlling amount is an amount of active ingredient which causes an adversely modifying effect to the vegetation e.g., causing deviations from natural development, killing, effecting regulation, causing desiccation, causing retardation, and the like.

[0057] As used herein, controlling undesirable vegetation means preventing, reducing, killing, or otherwise adversely modifying the development of plants and vegetation. Describedherein are methods of controlling undesirable vegetation through the application of certain herbicide combinations or compositions. Methods of application include, but are not limited to, applications to the vegetation or locus thereof, e.g., application to the area adjacent to the vegetation, as well as preemergence, postemergence, foliar (broadcast, directed, banded, spot, mechanical, over-the-top, or rescue), and in-water applications (emerged and submerged vegetation, broadcast, spot, mechanical, water-injected, granular broadcast, granular spot, shaker bottle, or stream spray) via hand, backpack, machine, tractor, or aerial (airplane and helicopter) application methods.

[0058] As used herein, plants and vegetation include, but are not limited to, germinant seeds, emerging seedlings, plants emerging from vegetative propagules, immature vegetation, and established vegetation.

[0059] As used herein, agriculturally acceptable salts and esters refer to salts and esters that exhibit herbicidal activity, or that are or can be converted in plants, water, or soil to the referenced herbicide. Exemplary agriculturally acceptable esters are those that are or can be hydrolyzed, oxidized, metabolized, or otherwise converted, e.g., in plants, water, or soil, to the corresponding carboxylic acid which, depending on the pH, may be in the dissociated or undissociated form.

[0060] Exemplary salts include those derived from alkali or alkaline earth metals and those derived from ammonia and amines. Exemplary cations include sodium, potassium, magnesium, and ammonium cations of the formula:

[0061] Herbicidal activity is exhibited by the compounds when they are applied directly to the plant or to the locus of the plant at any stage of growth. The effect observed depends upon the plant species to be controlled, the stage of growth of the plant, the application parameters of dilution and spray drop size, the particle size of solid components, the environmental conditions at the time of use, the specific compound employed, the specific adjuvants and carriers employed, the soil type, and the like, as well as the amount of chemical applied. These and other factors can be adjusted to promote nonselective or selective herbicidal action. In some aspects, the compositions described herein are applied as a post-emergence application, pre-emergence application, or in-water application to flooded paddy rice or water bodies (e.g., ponds, lakes, and streams), to relatively immature undesirable vegetation to achieve the maximum control of weeds.

[0062] In some aspects, the compositions and methods provided herein are utilized to control weeds in crops, including but not limited to direct-seeded, water-seeded and transplantedrice, cereals, wheat, barley, oats, rye, sorghum, corn / maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallow-land, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management (IVM) and rights of way (ROW).

[0063] With respect to the methods, in certain aspects, the methods comprise contacting the undesirable vegetation or locus thereof or applying to the soil or water to prevent the emergence or growth of vegetation or a composition described herein. In some aspects, the composition is applied at an application rate sufficient to control, inhibit, or promote the growth of at least one plant. In some aspects the compound is applied, based on the total amount of active ingredients in the composition, in at least one of the following ranges: of from about 200 grams to about 2,000 grams of acid equivalent per hectare (g ae / ha); in some aspects the composition is applied at an application rate of between about 400 grams to about 1,500 grams g ae / ha; in some aspects composition is applied at an application rate of between about 560 grams to about 1,200 grams g ae / ha; composition is applied at an application rate of between about 800 gram to about 1,120 grams g ae / h. In some aspects, the methods comprise contacting the undesirable vegetation or locus thereof or applying to the soil or water to prevent the emergence or growth of vegetation.

[0064] The compositions and methods provided herein are utilized to control undesirable vegetation. Undesirable vegetation includes, but is not limited to, undesirable vegetation that occurs in rice, cereals, wheat, barley, oats, rye, pastures, grasslands, rangelands, fallow-land, row crops (e.g., corn / maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton), turf, trees and vine orchards, plantation crops, vegetables, ornamental species, aquatic or noncrop settings (e.g., rights-of-way, industrial vegetation management).

[0065] In some aspects, the methods provided herein are utilized to control undesirable vegetation in rice. In certain aspects, the undesirable vegetation is Brachiaria platyphylla (Groseb.) Nash or Urochloa platyphylla (Nash) R.D. Webster (broadleaf signalgrass, BRAPP), Digitaria sanguinalis (L.) Scop, (large crabgrass, DIGSA), Echinochloa species (ECHSS), Echinochloa crus-galli (L.) P. Beauv. (barnyardgrass, ECHCG), Echinochloa crus-pavonis (Kunth) Schult, (gulf cockspur, ECHCV), Echinochloa colonum (L.) LINK (junglerice, ECHCO), Echinochloa oryzoides (Ard.) Fritsch (early watergrass, ECHOR), Echinochloa oryzicola (Vasinger) Vasinger (late watergrass, ECHPH), Echinochloa phyllopogon (Stapf) Koso-Pol. (rice bamyardgrass, ECHPH), Echinochloa polystachya (Kunth) Hitchc. (creeping river grass, ECHPO), Ischaemum rugosum Salisb. (saramollagrass, ISCRU), Leptochloa chinensis (L.) Nees (Chinese sprangletop, LEFCH), Leptochloa fascicularis (Lam.) Gray(bearded sprangletop, LEFFA), Leptochloa panicoides (Presl.) Hitchc. (Amazon sprangletop, LEFPA), Oryza species (red and weedy rice, ORYSS), Panicum dichotomiflorum (L.) Michx. (fall panicum, PANDI), Paspalum dilatatum Poir. (dallisgrass, PASDI), Rottboellia cochinchinensis (Lour.) W.D. Clayton (itchgrass, ROOEX), Cyperus species (CYPSS), Cyperus difformis L. (smallflower flatsedge, CYPDI), Cyperus dubius Rottb. (MAPDU), Cyperus esculentus L. (yellow nutsedge, CYPES), Cyperus iria L. (rice flatsedge, CYPIR), Cyperus rotundus L. (purple nutsedge, CYPRO), Cyperus serotinus Rottb. / C.B. Clarke (tidalmarsh flatsedge, CYPSE), Eleocharis species (ELOSS), Fimbristylis miliacea (L.) Vahl (globe fringerush, FIMMI), Schoenoplectus species (SCPSS), Schoenoplectus juncoides Roxb. (Japanese bulrush, SCPJU), Bolboschoenus maritimus (L.) Palla or Schoenoplectus maritimus L. Lye (sea clubrush, SCPMA), Schoenoplectus mucronatus L. (ricefield bulrush, SCPMU), Aeschynomene species, (jointvetch, AESSS), Altemanthera philoxeroides (Mart.) Griseb. (alligatorweed, ALRPH), Alisma plantago-aquatica L. (common waterplantain, ALSPA), Amaranthus species, (pigweeds and amaranths, AMASS), Ammannia coccinea Rottb. (redstem, AMMCO), Commelina benghalensis L. (Benghal dayflower, COMBE), Eclipta alba (L.) Hassk. (American false daisy, ECLAL), Heteranthera limosa (SW.) Willd. / Vahl (ducksalad, HETLI), Heteranthera reniformis R. & P. (roundleaf mudplantain, HETRE), Ipomoea species (morningglories, IPOSS), Ipomoea hederacea (L.) Jacq. (ivy leaf momingglory, IPOHE), Lindernia dubia (L.) Pennell (low false pimpernel, LIDDU), Ludwigia species (LUDSS), Ludwigia linifolia Poir. (southeastern primrose-willow, LUDLI), Ludwigia octovalvis (Jacq.) Raven (longfruited primrose-willow, LUDOC), Monochoria korsakowii Regel & Maack (monochoria, MOOKA), Monochoria vaginalis (Burm. F.) C. Presl ex Kuhth, (monochoria, MOOVA), Murdannia nudiflora (L.) Brenan (doveweed, MUDNU), Polygonum pensylvanicum L., (Pennsylvania smartweed, POLPY), Polygonum persicaria L. (ladysthumb, POLPE), Polygonum hydropiperoides Michx. (POLHP, mild smartweed), Rotala indica (Willd.) Koehne (Indian toothcup, ROTIN), Sagittaria species, (arrowhead, SAGSS), Sesbania exaltata (Raf.) Cory / Ry db. Ex Hill (hemp sesbania, SEBEX), or Sphenoclea zeylanica Gaertn. (gooseweed, SPDZE).

[0066] In some aspects, the methods provided herein are utilized to control undesirable vegetation in cereals. In certain aspects, the undesirable vegetation is Alopecurus myosuroides Huds. (blackgrass, ALOMY), Apera spica-venti (L.) Beauv. (windgrass, APESV), Avena fatua L. (wild oat, AVEFA), Bromus tectorum L. (downy brome, BROTE), Lolium multiflorum Lam. (Italian ryegrass, LOLMU), Phalaris minor Retz. (littleseed canarygrass, PHAMI), Poa annua L.(annual bluegrass, POANN), Setaria pumila (Poir.) Roemer & J. A. Schultes (yellow foxtail, SETLU), Setaria viridis (L.) Beauv. (green foxtail, SETVI), Amaranthus retroflexus L. (redroot pigweed, AMARE), Brassica species (BRSSS), Chenopodium album L. (common lambsquarters, CHEAL), Cirsium arvense (L.) Scop. (Canada thistle, CIRAR), Galium aparine L. (catchweed bedstraw, GALAP), Kochia scoparia (L.) Schrad. (kochia, KCHSC), Lamium purpureum L. (purple deadnettle , LAMPU), Matricaria recutita L. (wild chamomile, MATCH), Matricaria matricarioides (Less.) Porter (pineappleweed, MATMT), Papaver rhoeas L. (common poppy, PAPRH), Polygonum convolvulus L. (wild buckwheat, POLCO), Salsola tragus L. (Russian thistle, SASKR), Sinapis species (SINSS), Sinapis arvensis L. (wild mustard, SINAR), Stellaria media (L.) Vill. (common chickweed, STEME), Veronica persica Poir. (Persian speedwell, VERPE), Viola arvensis Murr. (field violet, VIOAR), or Viola tricolor L. (wild violet, VIOTR).

[0067] In some aspects, the methods provided herein are utilized to control undesirable vegetation in range and pasture, fallow land, IVM, and ROW. In certain aspects, the undesirable vegetation is Ambrosia artemisiifolia L. (common ragweed, AMBEL), Cassia obtusifolia (sickle pod, CASOB), Centaurea maculosa auct. non Lam. (spotted knapweed, CENMA), Cirsium arvense (L.) Scop. (Canada thistle, CIRAR), Convolvulus arvensis L. (field bindweed, CONAR), Daucus carota L. (wild carrot, DAUCA), Euphorbia esula L. (leafy spurge, EPHES), Lactuca serriola L. / Tom. (prickly lettuce, LACSE), Plantago lanceolata L. (buckhorn plantain, PLALA), Rumex obtusifolius L. (broadleaf dock, RUMOB), Sida spinosa L. (prickly sida, SIDSP), Sinapis arvensis L. (wild mustard, SINAR), Sonchus arvensis L. (perennial sowthistle, SONAR), Solidago species (goldenrod, SOOSS), Taraxacum officinale G.H. Weber ex Wiggers (dandelion, TAROF), Trifolium repens L. (white clover, TRFRE), or Urtica dioica L. (common nettle, URTDI).

[0068] In some aspects, the methods provided herein are utilized to control undesirable vegetation found in row crops, tree and vine crops, and perennial crops. In certain aspects, the undesirable vegetation is Alopecurus myosuroides Huds. (blackgrass, ALOMY), Avena fatua L. (wild oat, AVEFA), Brachiaria decumbens Stapf. or Urochloa decumbens (Stapf) R.D. Webster (Surinam grass, BRADC), Brachiaria brizantha (Hochst. ex A. Rich.) Stapf. or Urochloa brizantha (Hochst. ex A. Rich.) R.D. (beard grass, BRABR), Brachiaria platyphylla (Groseb.) Nash or Urochloa platyphylla (Nash) R.D. Webster (broadleaf signalgrass, BRAPP), Brachiaria plantaginea (Link) Hitchc. or Urochloa plantaginea (Link) R.D. Webster (alexandergrass, BRAPL), Cenchrus echinatus L. (southern sandbur, CENEC), Digitaria horizontalis Willd.(Jamaican crabgrass, DIGHO), Digitaria insularis (L.) Mez ex Ekman (sourgrass, TRCIN), Digitaria sanguinalis (L.) Scop, (large crabgrass, DIGSA), Echinochloa crus-galli (L.) P. Beauv. (barnyardgrass, ECHCG), Echinochloa colonum (L.) Link (junglerice, ECHCO), Eleusine indica (L.) Gaertn. (goosegrass, ELEIN), Lolium multiflorum Lam. (Italian ryegrass, LOLMU), Panicum dichotomiflorum Michx. (fall panicum, PANDI), Panicum miliaceum L. (wild-proso millet, PANMI), Setaria faberi Herrm. (giant foxtail, SETFA), Setaria viridis (L.) Beauv. (green foxtail, SETVI), Sorghum halepense (L.) Pers. (Johnsongrass, SORHA), Sorghum bicolor (L.) Moench ssp. Arundinaceum (shattercane, SORVU), Cyperus esculentus L. (yellow nutsedge, CYPES), Cyperus rotundus L. (purple nutsedge, CYPRO), Abutilon theophrasti Medik. (velvetleaf, ABUTH), Amaranthus species (pigweeds and amaranths, AMASS), Ambrosia artemisiifolia L. (common ragweed, AMBEL), Ambrosia psilostachya DC. (western ragweed, AMBPS), Ambrosia trifida L. (giant ragweed, AMBTR), Anoda cristata (L.) Schlecht. (spurred anoda, ANVCR), Asclepias syriaca L. (common milkweed, ASCSY), Bidens pilosa L. (hairy beggarticks, BIDPI), Borreria species (BOISS), Borreria alata (Aubl.) DC. or Spermacoce alata Aubl. (broadleaf buttonweed, BOILF), Spermacose latifolia (broadleaved button weed, BOILF), Chenopodium album L. (common lambsquarters, CHEAL), Cirsium arvense (L.) Scop. (Canada thistle, CIRAR), Commelina benghalensis L. (tropical spiderwort, COMBE), Datura stramonium L. (jimsonweed, DATST), Daucus carota L. (wild carrot, DAUCA), Euphorbia heterophylla L. (wild poinsettia, EPHHL), Euphorbia hirta L. or Chamaesyce hirta (L.) Millsp. (garden spurge, EPHHI), Euphorbia dentata Michx. (toothed spurge, EPHDE), Erigeron bonariensis L. or Conyza bonariensis (L.) Cronq. (hairy fleabane, ERIBO), Erigeron canadensis L. (Canadian fleabane, ERICA), Conyza sumatrensis (Retz.) E. H. Walker (tall fleabane, ERIFL), Helianthus annuus L. (common sunflower, HELAN), Jacquemontia tamnifolia (L.) Griseb. (smallflower morningglory, IAQTA), Ipomoea hederacea (L.) Jacq. (ivyleaf morningglory, IPOHE), Ipomoea lacunosa L. (white morningglory, IPOLA), Lactuca serriola L. / Torn. (prickly lettuce, LACSE), Portulaca oleracea L. (common purslane, POROL), Richardia species (pusley, RCHSS), Sida species (sida, SIDSS), Sida spinosa L. (prickly sida, SIDSP), Sinapis arvensis L. (wild mustard, SINAR), Solanum ptychanthum Dunal (eastern black nightshade, SOLPT), Tridax procumbens L. (coat buttons, TRQPR) or Xanthium strumarium L. (common cocklebur, XANST).

[0069] In some aspects, the methods provided herein are utilized to control undesirable vegetation in turf. In certain aspects, the undesirable vegetation is Bellis perennis L. (English daisy, BELPE), Cyperus esculentus L. (yellow nutsedge, CYPES), Cyperus species (CYPSS), Digitaria sanguinalis (L.) Scop, (large crabgrass, DIGSA), Diodia virginiana L. (Virginiabuttonweed, DIQVI), Euphorbia species (spurge, EPHSS), Glechoma hederacea L. (ground ivy, GLEHE), Hydrocotyle umbellata L. (dollarweed, HYDUM), Kyllinga species (kyllinga, KYLSS), Lamium amplexicaule L. (henbit, LAMAM), Murdannia nudiflora (L.) Brenan (doveweed, MUDNU), Oxalis species (woodsorrel, OXASS), Plantago major L. (broadleaf plantain, PLAMA), Plantago lanceolata L. (buckhom / narrowleaf plantain, PLALA), Phyllanthus urinaria L. (chamberbitter, PYLTE), Rumex obtusifolius L. (broadleaf dock, RUMOB), Stachys floridana Shuttlew. (Florida betony, STAFL), Stellaria media (L.) Vill. (common chickweed, STEME), Taraxacum officinale G.H. Weber ex Wiggers (dandelion, TAROF), Trifolium repens L. (white clover, TRFRE), or Viola species (wild violet, VIOSS).

[0070] In some aspects, the compositions and methods provided herein are utilized to control undesirable vegetation, including grass, broadleaf and sedge weeds. In certain aspects, the compositions and methods provided herein are utilized to control undesirable vegetation including but not limited to Alopecurus, Avena, Centaurea, Cyperus, Digitaria, Echinochloa, Ipomoea, Leptochloa and Sonchus.

[0071] In some aspects, the combination of a compound of Formula (I) or formulation hereof may be used to control Abutilon theophrasti Medik. (velvetleaf, ABUTH), Amaranthus rudis Sauer, (common waterhemp, AMATA), Chenopodium album L. (common lambsquarters, CHEAL), Polygonum convolvulus L. (wild buckwheat, POLCO) and Sinapis arvensis L. (wild mustard, SINAR).

[0072] The compounds of Formula (I) or agriculturally acceptable formulation of the same may be used to control herbicide resistant or tolerant weeds. Exemplary resistant or tolerant weeds include, but are not limited to, biotypes resistant or tolerant to acetolactate synthase (ALS) or acetohydroxy acid synthase (AHAS) inhibitors, (e.g., imidazolinones, sulfonylureas, pyrimidinylthiobenzoates, triazolopyrimidines, and sulfonylaminocarbonyltriazolinones), photosystem II inhibitors (e.g., phenylcarbamates, pyridazinones, triazines, triazinones, uracils, amides, ureas, benzothiadiazinones, nitriles, phenylpyridazines), acetyl CoA carboxylase (ACCase) inhibitors, (e.g., aryloxyphenoxypropionates, cyclohexanediones, phenylpyrazolines), synthetic auxins (e.g., benzoic acids, phenoxycarboxylic acids, pyridine carboxylic acids, quinoline carboxylic acids), auxin transport inhibitors (e.g., phthalamates, semicarbazones), photosystem I inhibitors (e.g., bipyridyliums), 5 -enolpyruvylshikimate-3 -phosphate (EPSP) synthase inhibitors (e.g., glyphosate), glutamine synthetase inhibitors (e.g., glufosinate, bialafos), microtubule assembly inhibitors (e.g., benzamides, benzoic acids, dinitroanilines, phosphoramidates, pyridines),mitosis inhibitors (e.g., carbamates), very long chain fatty acid (VLCFA) inhibitors (e.g., acetamides, chloroacetamides, oxyacetamides, tetrazolinones), fatty acid and lipid synthesis inhibitors (e.g., phosphorodithioates, thiocarbamates, benzofuranes, chlorocarbonic acids), protoporphyrinogen oxidase (PPO) inhibitors (e.g., diphenylethers, N-phenylphthalimides, oxadiazoles, oxazolidinediones, phenylpyrazoles, pyrimidindiones, thiadiazoles, triazolinones), carotenoid biosynthesis inhibitors (e.g., clomazone, amitrole, aclonifen), phytoene desaturase (PDS) inhibitors (e.g., amides, anilidex, furanones, phenoxybutan-amides, pyridiazinones, pyridines), 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors (e.g., calli stem ones, isoxazoles, pyrazoles, triketones), cellulose biosynthesis inhibitors (e.g., nitriles, benzamides, quinclorac, triazolocarboxamides), herbicides with multiple modes-of-action such as quinclorac, and unclassified herbicides such as arylaminopropionic acids, difenzoquat, endothall, and organoarsenicals. Exemplary resistant or tolerant weeds include, but are not limited to, biotypes with resistance or tolerance to multiple herbicides, biotypes with resistance or tolerance to multiple chemical classes, biotypes with resistance or tolerance to multiple herbicide modes-of- action, and biotypes with multiple resistance or tolerance mechanisms (e.g., target site resistance or metabolic resistance).

[0073] In some aspects, the methods and compositions provided herein are utilized as a mixture or co-application in combination with another pesticide. In some aspects, the application of the pesticide does not coincide with the application of the compositions provided herein.

[0074] In a further embodiment, the pesticide belongs to a class of pesticides selected from the group consisting of fungicides, nematicides, bactericides, and insecticides.

[0075] With respect to the methods for treating crop fields to reduce or eliminate the growth of unwanted plants, these methods may comprise contacting the undesirable vegetation or locus thereof or applying to the soil or water to prevent the emergence or growth of vegetation or a composition described herein. In some aspects, the composition is applied at an application rate of from about 1 gram of acid equivalent per hectare (g ae / ha) to about 400 grams active ingredient per hectare (gai / ha) based on the total amount of active ingredients in the composition. In certain aspects, the composition is applied at an application rate of from about 4 grams acid equivalent per hectare (g ae / ha) to about 400 g ae / ha based on the total amount of active ingredients in the composition.

[0076] With respect to the methods, in certain aspects, the methods comprise contacting the undesirable vegetation or locus thereof or applying to the soil or water to prevent theemergence or growth of vegetation or a composition described herein. In some aspects, the composition is applied at an application rate sufficient to control, inhibit, or promote the growth of at least one plant. In some aspects the compound is applied, based on the total amount of active ingredients in the composition, in at least one of the following ranges: of from: about 1 gram to about 1,000 grams of acid equivalent per hectare (g ae / ha); in some aspects the composition is applied at an application rate of between about 1 gram to about 500 grams g ae / ha; in some aspects composition is applied at an application rate of between about 1 gram to about 250 grams g ae / ha; composition is applied at an application rate of between about 1 gram to about 140 grams g ae / h; in some aspects the composition is applied at an application rate of between about 1 gram to about 70 grams g ae / ha. In some aspects, the methods comprise contacting the undesirable vegetation or locus thereof or applying to the soil or water to prevent the emergence or growth of vegetation.

[0077] In some aspects, the concentration of the active ingredients in the compositions described herein is from about 0.0005 to 98 percent by weight. In some aspects, the concentration is from about 0.0006 to 90 percent by weight. In compositions designed to be employed as concentrates, the active ingredients, in certain aspects, are present in a concentration from about 0.1 to 98 weight percent, and in certain aspects about 0.5 to 90 weight percent. Such compositions are, in certain aspects, diluted with an inert carrier, such as water, before application. The diluted compositions usually applied to weeds or the locus of weeds contain, in certain aspects, about 0.0006 to 3.0 weight percent active ingredient and in certain aspects contain about 0.01 to 1.0 weight percent.

[0078] The present compositions can be applied to weeds or their locus by almost any conventional means of application, including but not limited to the use of aerial dusters, sprayers, and granule applicators. Under some circumstances these compounds and formulations thereof may be added to irrigation or paddy water, which is then used to treat plants, soil, and other surfaces.

[0079] In an embodiment the disclosure relates to compositions and method for controlling weeds using a herbicide composition listed in Table 1. In an embodiment the application applies to transgenic crop plants comprising a 2,4-D resistant gene. In certain embodiments the weeds are broad-leaved weeds (dicot weeds). In other embodiments the weeds are grass weeds (monocot weeds). In an embodiment, the herbicide composition listed in Table 1 is applied sequentially with a second herbicide composition.

[0080] In other embodiments, the herbicide composition listed in Table 1 is applied concurrently with a second herbicide composition. In an aspect of the embodiment the herbicide composition listed in Table 1 and the second herbicide composition maybe be applied at early post-emergence stage, wherein the transgenic crop begins to sprout between growth stages VC to V3. In another aspect of the embodiment the herbicide composition listed in Table 1 and the second herbicide composition maybe be applied at late post-emergence stage, wherein the transgenic crop begins to develop between growth stages V4 to R2. In some aspects of the embodiment the herbicide composition listed in Table 1 and the second herbicide composition maybe be applied at pre-harvest stage, wherein the transgenic crop begins to is physiologically mature, but not yet harvested. In further aspects of the embodiment the herbicide composition listed in Table 1 and the second herbicide composition maybe be applied at post-harvest stage, wherein the transgenic crop has been harvested. In an additional aspect of the embodiment the herbicide composition listed in Table 1 and the second herbicide composition maybe be applied as a pre-emergent application, wherein the transgenic crop and weed has not yet emerged either before or after planting. In some embodiments of this aspect the herbicide is not planted in the soil within at least 30, 29, 28, 27, 26, 25, 24, 23, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3, 2, or 1 days before or after the herbicide is applied.

[0081] In further embodiments, the method of controlling weeds in transgenic crop plants results in identifying a herbicide resistant broad-leaved weed or grass weed that is tolerant to at least the second herbicide composition and applying an amount of herbicide composition listed in Table 1 effective to control the herbicide resistant broad-leaved weed or grass weed.

[0082] In other embodiments, the method and compositions of the disclosure relate to a cropping system for minimizing the development of a herbicide resistant broad-leaved weed or grass weed in a crop-growing environment. In an aspect of this embodiment a field is planted to a crop plant having tolerance to a first herbicide and / or a herbicide composition listed in Table 1. In another aspect of this embodiment a first herbicide treatment comprising a first herbicide, and / or herbicide composition listed in Table 1 is applied to the crop growing environment to control weeds. In a further aspect of this embodiment a location in the field that is infested with weeds resistant to a first herbicide is identified. In an additional aspect of this embodiment an amount of the herbicide composition listed in Table leffective to control the weeds resistant to a first herbicide is applied. “Cropping system” refers to an interactive combination of a crop, any herbicide tolerance exhibited by it, and accompanying herbicidal treatment options available at different stages of crop development, yielding a productive crop. In aspects of the embodiment,the first herbicide can include glyphosate, glufosinate, PPO, dicamba, HPPD, ALS type herbicides as examples of non-limiting disclosure.

[0083] In an additional embodiment the subject disclosure provides a method for minimizing the development of a herbicide resistant weed comprising: rotating a first cropping system in a first growing season with a second cropping system in a subsequent growing season, wherein the first and second cropping systems comprise a cropping system utilizing the herbicide composition listed in Table 1 effective to control the weeds resistant to herbicides. In an aspect of this embodiment the crop plant in the first cropping system possesses at least one different herbicide tolerance relative to the crop plant in the second cropping system. In a further aspect of this embodiment the first cropping system and crop plant in the second cropping system are the same species. In an additional aspect of this embodiment the crop plant in the first cropping system and crop plant in the second cropping system are different species.

[0084] In a further embodiment, the subject disclosure provides for a glyphosate tolerant weed in a field where a transgenic seed is planted in the field comprising a glyphosate tolerant weed or a seed thereof. In an aspect of this embodiment the transgenic seed comprises a transgene conferring glyphosate tolerance and a transgene encoding tolerance to a herbicide composition listed in Table 1. In another aspect the seed grows into a plant. In further aspects the field is treated with an amount of a herbicide composition listed in Table 1 and glyphosate effective to control weed growth of the glyphosate tolerant weed.

[0085] In an embodiment, the subject disclosure provides for a method of controlling weed growth in a field by planting a transgenic seed in a field comprising a weed or a seed thereof. In an aspect of this embodiment the transgenic seed comprises a transgene conferring resistance to a herbicide composition listed in Table 1 and at least a second transgene conferring resistance to a second herbicide compound. In another aspect the field is treated with a herbicidally effective amount of herbicide composition listed in Table 1, at least a second herbicide compound, or a mixture thereof resulting in growing a plant from the transgenic seed.

[0086] In an embodiment, the subject disclosure provides for methods of assaying an herbicide tolerance characteristic in a plant by treating at least one plant or seed with a herbicidally effective amount of a herbicide composition listed in Table 1 A crop tolerant to one or more herbicides belonging to different mode of action groups is produced and utilized in a cropping system of the present invention. These herbicides are approved by Weed Science Society of America (WSSA) and non-limiting examples are found in Table 2 (Mallory-Smith and Retzinger Jr, 2003; Herbicide Handbook, 2002; Schmidt, 1997). and evaluating one or moreproperties of the at least one plant treated with the herbicidally effective amount of a herbicide composition listed in Table 1.

[0087] With respect to the methods for treating crop fields to reduce or eliminate the growth of unwanted plants, these methods may comprise contacting a transgenic plant that is resistant to the active ingredients in the compositions described of Table 1, herein. The application of such compositions can control undesirable vegetation or locus thereof or applying to the soil or water to prevent the emergence or growth of undesirable vegetation. In an embodiment, the transgenic plant comprises a 2,4-D resistant gene.

[0088] In further aspects and embodiments, the 2,4-D resistance gene comprises an aad-12 gene. The aad-12 gene provides for resistance to 2,4-D, and also to pyridyloxyacetate herbicides. The aad-12 gene encodes an enzyme that degrades both 2,4-D, and pyridyloxyacetate herbicides as provided in U.S. Patent No. 8,283,522B2, herein incorporated by reference in its entirety. The aad-12 gene and encoded protein is disclosed herein as SEQ ID NO: 1-SEQ ID NON. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0089] In further aspects and embodiments, the 2,4-D resistance gene comprises an aad-1 gene. The aad-1 gene provides for resistance to 2,4-D, and also to aryl oxy phenoxy propionate herbicides. The aad-1 gene encodes an enzyme that degrades both 2,4-D, and aryl oxy phenoxy propionate herbicides as provided in U.S. Patent No. 11,299,745B1, herein incorporated by reference in its entirety. The aad-1 gene and encoded protein is disclosed herein as SEQ ID NO:5-SEQ ID NO:9. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0090] In further aspects and embodiments, the 2,4-D resistance gene comprises an aad-2 gene. The aad-2 gene provides for resistance to 2,4-D, and also to aryl oxy phenoxy propionate herbicides. The aad-2 gene encodes an enzyme that degrades both 2,4-D, and aryl oxy phenoxy propionate herbicides as provided in U.S. Patent No. 11,299,745B1, herein incorporated by reference in its entirety. The aad-2 gene and encoded protein is disclosed herein as SEQ ID NO: 1 and SEQ ID NO: 11. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants canbe treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0091] In further aspects and embodiments, the 2,4-D resistance gene comprises an aad-13 gene. The aad-13 gene provides for resistance to 2,4-D, and also to aryloxyalkanoate herbicides. The aad-13 gene encodes an enzyme that degrades both 2,4-D, and aryloxyalkanoate herbicides as provided in U.S. Patent No. 9,624, 505B2, herein incorporated by reference in its entirety. The aad-13 gene and encoded protein is disclosed herein as SEQ ID NO: 12 and SEQ ID NO: 15.This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0092] In further aspects and embodiments, the 2,4-D resistance gene comprises a tfdA gene. The tfdA gene provides for resistance to 2,4-D. The tfdA gene encodes an enzyme that degrades 2,4-D, herbicides as provided in U.S. Patent No. 6,153,401 A, herein incorporated by reference in its entirety. The tfdA gene and encoded protein is disclosed herein as SEQ ID NO: 16. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0093] In further aspects and embodiments, the 2,4-D resistance gene comprises an 24DT22 gene. The 24DT22 gene provides for resistance to 2,4-D and aryloxyalkanoate di-oxygenase herbicides. The 24DT22 gene encodes an enzyme that degrades 2,4-D and also aryloxyalkanoate di-oxygenase herbicides as provided in U.S. Patent No. 10,655,140, herein incorporated by reference in its entirety. The 24DT22 gene and encoded protein is disclosed herein as SEQ ID NO: 17 and SEQ ID NO: 18. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0094] In further aspects and embodiments, the 2,4-D resistance gene comprises an 24DT21 gene. The 24DT21 gene provides for resistance to 2,4-D and aryloxyalkanoate di-oxygenase herbicides. The 24DT21 gene encodes an enzyme that degrades 2,4-D and also aryloxyalkanoate di-oxygenase herbicides as provided in U.S. Patent No. 10,562,944, herein incorporated by reference in its entirety. The 24DT21 gene and encoded protein is disclosed herein as SEQ IDNO: 19 and SEQ ID NO:20. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0095] In further aspects and embodiments, the 2,4-D resistance gene comprises an 24DT11 gene. The 24DT11 gene provides for resistance to 2,4-D and aryloxyalkanoate di-oxygenase herbicides. The 24DT11 gene encodes an enzyme that degrades 2,4-D and also aryloxyalkanoate di-oxygenase herbicides as provided in U.S. Patent No. 9,462,805, herein incorporated by reference in its entirety. The 24DT11 gene and encoded protein is disclosed herein as SEQ ID NO:21 and SEQ ID NO:22. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0096] In further aspects and embodiments, the 2,4-D resistance gene comprises an IAA2 gene. The IAA2 gene provides for resistance to 2,4-D and synthetic auxin herbicides. The IAA2 gene encodes an enzyme that degrades 2,4-D and also synthetic auxin herbicides as provided in U.S. Patent Publication No. 20220127633, herein incorporated by reference in its entirety. The IAA2 gene and encoded protein is disclosed herein as SEQ ID NO:23 and SEQ ID NO:24. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0097] In further aspects and embodiments, the 2,4-D resistance gene comprises a modified RdpA gene. The modified RdpA gene provides for resistance to 2,4-D and pyridyloxy acid herbicides. The modified RdpA gene encodes an enzyme that degrades 2,4-D and also pyridyloxy acid herbicides as provided in International Patent Publication No.WO2023160362A1, herein incorporated by reference in its entirety. The modified RdpA gene and encoded protein is disclosed herein as SEQ ID NO:25 and SEQ ID NO:33. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0098] In further aspects and embodiments, the 2,4-D resistance gene comprises an FT_T gene and / or an FT_Tv7 gene. The FT_T gene and / or an FT_Tv7 gene provides for resistance to 2,4-D, and also to aryl oxy phenoxy propionate herbicides. The FT_T gene and / or an FT_Tv7 gene encodes an enzyme that degrades both 2,4-D, and aryloxyphenoxypropionate herbicides as provided in Larue, Clayton T., et al. "Development of enzymes for robust aryl oxy phenoxy propionate and synthetic auxin herbicide tolerance traits in maize and soybean crops." Pest management science 75.8 (2019): 2086-2094, herein incorporated by reference in its entirety. The FT_T gene and / or an FT_Tv7 gene and encoded protein is disclosed herein as SEQ ID NO:34 and SEQ ID NO:35. This trait can be incorporated into plants to provide protection to the compositions provided in Table 1, herein. These resulting transgenic plants can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0099] In further aspects and embodiments, the 2,4-D resistance gene comprises any of the following genes: aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11,IAA2, modified RdpA, FT_T or an FT_Tv7 gene. These sequences are disclosed as the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35 (or a polynucleotide encoding the amino acid sequence thereof). Further aspects include variants of the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35 (or a polynucleotide encoding the amino acid sequence thereof). Other aspects include variants of the aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T or an FT_Tv7 genes, as disclosed herein. As used herein, the term "variant(s)" means substantially similar sequences. For nucleotide sequences, naturally occurring variants can be identified with the use of well-known molecular biology techniques, such as, for example, with polymerase chain reaction (PCR) and hybridization techniques as outlined herein. For nucleotide sequences, a variant comprises a deletion and / or addition of one or more nucleotides at one or more internal sites within the native polynucleotide and / or a substitution of one or more nucleotides at one or more sites in the native polynucleotide. As used herein, a "native" nucleotide sequence comprises a naturally occurring nucleotide sequence. For nucleotide sequences, naturally occurring variants can be identified with the use of well-known molecular biology techniques, as, for example, with polymerase chain reaction (PCR) and hybridization techniques as outlined below. Variant nucleotide sequences also include synthetically derived nucleotide sequences, such as those generated, for example, by using site-directed mutagenesis. Generally, variants of a particular nucleotide sequence of the disclosure will have at least about 40%, 45%, 50%, 55%,60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%o, 99% or more sequence identity to that particular nucleotide sequence as determined by sequence alignment programs and parameters described elsewhere herein. A biologically active variant of a nucleotide sequence of the disclosure may differ from that sequence by as few as 1-15 nucleic acid residues, as few as 1-10, such as 6-10, as few as 5, as few as 4, 3, 2, or even 1 nucleic acid residue.

[0100] In further aspects and embodiments, the 2,4-D resistance gene comprises a transgenic event. The MON87429 transgenic event provides for resistance to glyphosate, glufosinate, dicamba, 2,4-D, and aryl oxy phenoxy propionate herbicides. The MON87429 event comprises four genes that encode enzymes which degrades these herbicides as disclosed in U.S. Patent No. 10,920,239, herein incorporated by reference in its entirety. Transgenic plants that comprise the MON87429 event can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0101] In further aspects and embodiments, the 2,4-D resistance gene comprises a transgenic event. The MON94313 (or GM CSM63714) transgenic event provides for resistance to HPPD, glufosinate, 2,4-D, and aryl oxy phenoxy propionate herbicides. The MON94313 (or GM_CSM63714) event comprises four genes that encode enzymes which degrades these herbicides as disclosed in U.S. Patent Publication No. 20230348927, herein incorporated by reference in its entirety. Transgenic plants that comprise the MON94313 (or GM_CSM63714) event can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0102] In further aspects and embodiments, the 2,4-D resistance gene comprises a transgenic event. The MON80616 (or ZM CSM63157) transgenic event provides for resistance to PPO herbicides. The MON80616 (or ZM_CSM63157) event comprises four genes that encode enzymes which degrades these herbicides. Transgenic plants that comprise the MON80616 (or ZM CSM63157) event can be treated sequentially with one, two, or a combination of the compositions provided in Table 1, herein to provide resistance to the herbicidal effects of these compositions.

[0103] Transgenes of interest may be stacked with the 2,4-D resistance gene of the subject disclosure. Exemplary transgenes of interest that are suitable include, but are not limited to, coding sequences that confer (1) resistance to pests or disease, (2) tolerance to herbicides, (3) value added agronomic traits, such as; yield improvement, nitrogen use efficiency, water useefficiency, and nutritional quality, (4) binding of a protein to DNA in a site specific manner, (5) expression of small RNA, and (6) selectable markers. In accordance with one embodiment, the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35 (or a polynucleotide encoding the amino acid sequence thereof) is stacked with a transgene / heterologous coding sequence encoding a selectable marker or a gene product conferring insecticidal resistance, herbicide tolerance, small RNA expression, nitrogen use efficiency, water use efficiency, or nutritional quality.

[0104] 1. Insect Resistance

[0105] Various insect resistance genes can be stacked with the 2,4-D resistance gene comprising SEQ ID NO: 1 to SEQ ID NO:35. The stacked linked sequences can then be incorporated into a chosen vector to allow for identification and selection of transformed plants (“transformants”). Exemplary insect resistance coding sequences are known in the art. As embodiments of insect resistance coding sequences that can be operably linked to the compositions of the subject disclosure, the following traits are provided. Coding sequences that provide exemplary Lepidopteran insect resistance include: crylA; cry 1 A.105; cry 1 Ab; cry 1 Ab (truncated); cryl Ab-Ac (fusion protein); cryl Ac (marketed in cotton with crylF as Widestrike®); crylC; crylF (marketed in cotton with crylAc as Widestrike®); crylFa2; cry2Ab2; cry2Ae; cry9C; mocrylF; pinll (protease inhibitor protein); vip3A(a); and vip3Aa20. Coding sequences that provide exemplary Coleopteran insect resistance include: cry34Abl (marketed as Herculex®); cry35Abl (marketed as Herculex®); cry3A; cry3Bbl; dvsnf7; and mcry3 A. Coding sequences that provide exemplary multi-insect resistance include ecry31.Ab. The above list of insect resistance genes is not meant to be limiting. Any insect resistance genes are encompassed by the present disclosure.

[0106] 2. Herbicide Tolerance

[0107] Various herbicide tolerance genes can be stacked with the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35 (or a polynucleotide encoding the amino acid sequence thereof). The stacked linked sequences can then be incorporated into a chosen vector to allow for identification and selection of transformed plants (“transformants”). Exemplary herbicide tolerance coding sequences are known in the art. As embodiments of herbicide tolerance coding sequences that can be operably linked to the compositions of the subject disclosure, the following traits are provided. The glyphosate herbicide contains a mode of action by inhibiting the EPSPS enzyme (5 -enolpyruvylshikimate-3 -phosphate synthase). This enzyme is involved in the biosynthesis of aromatic amino acids that are essential for growth anddevelopment of plants. Various enzymatic mechanisms are known in the art that can be utilized to inhibit this enzyme. The genes that encode such enzymes can be operably linked to the compositions of the subject disclosure. In an embodiment, selectable marker genes include, but are not limited to genes encoding glyphosate resistance genes include, but are not limited to: glyphosate-insensitive EPSPS genes such as 2mEPSPS, cp4 EPSPS, mEPSPS, dgt-28; epsps grg23ace5; and aroA genes; and as well as glyphosate-degradation genes such as glyphosate acetyl transferase genes (gat) and glyphosate oxidase genes (gox). These traits may be found in products currently marketed as EnlistE3®, GT27, Gly-TolTM, Optimum® GAT®, Genuity Roundup Ready2 Yield®, and Roundup Ready®. Resistance genes for glufosinate and / or bialaphos compounds include dsm-2, mat, hpat, bar and pat genes. The pat gene is in the trait currently marketed as LibertyLink®, LlibertyLink GT27, EnlistE3®, ConkestaE3®, and Genuity Roundup Ready2 XtendFlex Soybean. Also included are tolerance genes that provide resistance to 2,4-D (and other phen oxy auxin herbicides) such as aad-1, rdpA, and ft-t genes (it should be noted that these genes have further activity on aryl oxy phenoxy propionate (aka ‘fop’) herbicides) and aad-12, spdA, and tfdA genes (it should be noted that aad-12 genes have further activity on pyridyloxyacetate synthetic auxins like fluroxypyr and triclopyr). AAD-12 traits are marketed as Enlist® crop protection technology. Note Resistance genes for ALS inhibitors (sulfonylureas, imidazolinones, triazolopyrimidines, pyrimidinylthiobenzoates, and sulfonylamino-carbonyl- triazolinones) are known in the art. These resistance genes most commonly result from point mutations to the ALS encoding gene sequence. Other ALS inhibitor resistance genes include hra genes, the csrl-2 genes, Sr-HrA genes, and surB genes. Some of the traits are marketed under the tradename Cultivance, STS, Bolt, or Optimum GAT Clearfield®. Herbicides that inhibit HPPD include the pyrazolones such as pyrazoxyfen, benzofenap, and topramezone; triketones such as mesotrione, sulcotrione, tembotrione, benzobicyclon; and diketonitriles such as isoxaflutole. These exemplary HPPD herbicides can be tolerated by known traits. Examples of HPPD inhibitors include hppdPF_W336 , hppdPf-4Pa , tdo / hisl / hsl 1 , avhppd-03 genes (for resistance to isoxaflutole, meostrione, or other HPPD-inhibitor herbicides). An example of oxynil herbicide tolerant traits include the bxn gene, which has been showed to impart resistance to the herbicide / antibiotic bromoxynil. Resistance genes for dicamba include the dicamba monooxygenase gene (dmo) as disclosed in International PCT Publication No.WO 2008 / 105890. Resistance genes for PPO or PROTOX inhibitor type herbicides (e.g., acifluorfen, butafenacil, flupropazil, pentoxazone, carfentrazone, fluazolate, pyraflufen, aclonifen, azafenidin, flumioxazin, flumiclorac, bifenox, oxyfluorfen, lactofen, fomesafen,fluoroglycofen, epyrfenacil, saflufenacil, trifludimoxazin, tiafenacil, and sulfentrazone) are known in the art. Exemplary genes conferring resistance to PPO include herbicide insensitive forms of the PPO target enzyme from plants (US10100329, US10041087, US7671254, US6288306). Bacteria (hemY, hemG, H_N90), or other species over expression of a wild-type Arabidopsis thaliana PPO enzyme (Lermontova I and Grimm B, (2000) Overexpression of plastidic protoporphyrinogen IX oxidase leads to resistance to the diphenyl-ether herbicide acifluorfen. Plant Physiol 122:75-83.), the B. subtilis PPO gene (Li, X. and Nicholl D. 2005. Development of PPO inhibitor-resistant cultures and crops. Pest Manag. Sci. 61 :277-285 and Choi KW, Han O, Lee HJ, Yun YC, Moon YH, Kim MK, Kuk YI, Han SU and Guh JO, (1998) Generation of resistance to the diphenyl ether herbicide, oxyfluorfen, via expression of the Bacillus subtilis protoporphyrinogen oxidase gene in transgenic tobacco plants. Biosci Biotechnol Biochem 62:558-560.) Resistance genes for ay rl oxy phenoxy propionate(AOPP) and cyclohexone (DIM) include the herbicide insensitive forms of ACCase (AcetylCoA Carboxylase) genes (e.g., Accl-Sl, Accl-S2 and Accl-S3). Exemplary genes conferring resistance to cyclohexanediones and / or aryloxyphenoxypropanoic acid include sethoxydim, clethodim, cycloxydim, haloxyfop, diclofop, fenoxyprop, fluazifop, and quizalofop, among others. AOPP herbicide tolerance is also a second herbicide class enabled by genes such as aad- 1, rdpA, and ft_t. Finally, herbicides can inhibit photosynthesis, including triazine or benzonitrile are provided tolerance by psbA genes (tolerance to triazine), ls+ genes (tolerance to triazine), and nitrilase genes (tolerance to benzonitrile). The above list of herbicide tolerance genes is not meant to be limiting. Any herbicide tolerance genes are encompassed by the present disclosure.

[0108] 3. Agronomic Traits

[0109] Various agronomic trait genes can be stacked with the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35(or a polynucleotide encoding the amino acid sequence thereof). The stacked linked sequences can then be incorporated into a chosen vector to allow for identification and selection of transformed plants (“transformants”). Exemplary agronomic trait coding sequences are known in the art. As embodiments of agronomic trait coding sequences that can be operably linked to the compositions of the subject disclosure, the following traits are provided. Delayed fruit softening as provided by the pg genes inhibit the production of polygalacturonase enzyme responsible for the breakdown of pectin molecules in the cell wall, and thus causes delayed softening of the fruit. Further, delayed fruit ripening / senescence of acc genes act to suppress the normal expression of the native accsynthase gene, resulting in reduced ethylene production and delayed fruit ripening. Whereas, the accd genes metabolize the precursor of the fruit ripening hormone ethylene, resulting in delayed fruit ripening. Alternatively, the sam-k genes cause delayed ripening by reducing S- adenosylmethionine (SAM), a substrate for ethylene production. Drought stress tolerance phenotypes as provided by cspB genes maintain normal cellular functions under water stress conditions by preserving RNA stability and translation. Another example includes the EcBetA genes that catalyze the production of the osmoprotectant compound glycine betaine conferring tolerance to water stress. In addition, the RmBetA genes catalyze the production of the osmoprotectant compound glycine betaine conferring tolerance to water stress. Photosynthesis and yield enhancement is provided with the bbx32 gene that expresses a protein that interacts with one or more endogenous transcription factors to regulate the plant’s day / night physiological processes. Ethanol production can be increase by expression of the amy797E genes that encode a thermostable alpha-amylase enzyme that enhances bioethanol production by increasing the thermostability of amylase used in degrading starch. Finally, modified amino acid compositions can result by the expression of the cordapA genes that encode a dihydrodipicolinate synthase enzyme that increases the production of amino acid lysine. The above list of agronomic trait coding sequences is not meant to be limiting. Any agronomic trait coding sequence is encompassed by the present disclosure.

[0110] 4. DNA Binding Proteins

[0111] Various DNA binding transgene / heterologous coding sequences can be stacked with the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35. The stacked linked sequences can then be incorporated into a chosen vector to allow for identification and selectable of transformed plants (“transformants”). Exemplary DNA binding protein coding sequences are known in the art. As embodiments of DNA binding protein coding sequences that can be operably linked to the compositions of the subject disclosure, the following types of DNA binding proteins can include; Zinc Fingers, TALENS, CRISPRS, and meganucleases. The above list of DNA binding protein coding sequences is not meant to be limiting. Any DNA binding protein coding sequences is encompassed by the present disclosure.

[0112] 5. Small RNA

[0113] Various small RNA sequences can be stacked with the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35(or a polynucleotide encoding the amino acid sequence thereof). The stacked linked sequences can then be incorporated into a chosen vector to allow for identification and selection of transformed plants (“transformants”). Exemplarysmall RNA traits are known in the art. As embodiments of small RNA coding sequences that can be operably linked to the compositions of the subject disclosure, the following traits are provided. For example, delayed fruit ripening / senescence of the anti-efe small RNA delays ripening by suppressing the production of ethylene via silencing of the ACO gene that encodes an ethylene-forming enzyme. The altered lignin production of ccomt small RNA reduces content of guanacyl (G) lignin by inhibition of the endogenous S-adenosyl-L-m ethionine: trans-caffeoyl CoA 3-O-methyltransferase (CCOMT gene). Further, the Black Spot Bruise Tolerance in Solanum verrucosum can be reduced by the Ppo5 small RNA which triggers the degradation of Ppo5 transcripts to block black spot bruise development. Also included is the dvsnf7 small RNA that inhibits Western Com Rootworm with dsRNA containing a 240 bp fragment of the Western Com Rootworm Snf7 gene. Modified starch / carbohydrates can result from small RNA such as the pPhL small RNA (degrades PhL transcripts to limit the formation of reducing sugars through starch degradation) and pRl small RNA (degrades R1 transcripts to limit the formation of reducing sugars through starch degradation). Additional, benefits such as reduced acrylamide resulting from the asnl small RNA that triggers degradation of Asnl to impair asparagine formation and reduce polyacrylamide. Finally, the non-browning phenotype of pgas ppo suppression small RNA results in suppressing PPO to produce apples with a non-browning phenotype. The above list of small RNAs is not meant to be limiting. Any small RNA encoding sequences are encompassed by the present disclosure.

[0114] 6. Selectable Markers

[0115] Various selectable markers also described as reporter genes can be stacked with the 2,4-D resistance gene comprising any of SEQ ID NO: 1 to SEQ ID NO:35 (or a polynucleotide encoding the amino acid sequence thereof). The stacked linked sequences can then be incorporated into a chosen vector to allow for identification and selectable of transformed plants (“transformants”). Many methods are available to confirm expression of selectable markers in transformed plants, including for example DNA sequencing and PCR (polymerase chain reaction), Southern blotting, RNA blotting, immunological methods for detection of a protein expressed from the vector. But, usually the reporter genes are observed through visual observation of proteins that when expressed produce a colored product. Exemplary reporter genes are known in the art and encode P-glucuronidase (GUS), luciferase, green fluorescent protein (GFP), yellow fluorescent protein (YFP, Phi-YFP), red fluorescent protein (DsRFP, RFP, etc), P-galactosidase, and the like (See Sambrook, et al., Molecular Cloning: A LaboratoryManual, Third Edition, Cold Spring Harbor Press, N.Y., 2001, the content of which is incorporated herein by reference in its entirety).

[0116] Selectable marker genes are utilized for selection of transformed cells or tissues. Selectable marker genes include genes encoding antibiotic resistance, such as those encoding neomycin phosphotransferase II (NEO), spectinomycin / streptinomycin resistance (AAD), and hygromycin phosphotransferase (HPT or HGR) as well as genes conferring resistance to herbicidal compounds. Herbicide resistance genes generally code for a modified target protein insensitive to the herbicide or for an enzyme that degrades or detoxifies the herbicide in the plant before it can act. For example, resistance to glyphosate has been obtained by using genes coding for mutant target enzymes, 5 -enolpyruvylshikimate-3 -phosphate synthase (EPSPS). Genes and mutants for EPSPS are well known, and further described below. Resistance to glufosinate ammonium, bromoxynil, and 2,4-dichlorophenoxyacetate (2,4-D) have been obtained by using bacterial genes encoding PAT or DSM-2, a nitrilase, an AAD-1, or an AAD-12, each of which are examples of proteins that detoxify their respective herbicides.

[0117] In an embodiment, herbicides can inhibit the growing point or meristem, including imidazolinone or sulfonylurea, and genes for resistance / tolerance of acetohydroxyacid synthase (AHAS) and acetolactate synthase (ALS) for these herbicides are well known. Glyphosate resistance genes include mutant 5 -enolpyruvylshikimate-3 -phosphate synthase (EPSPs) and dgt- 28 genes (via the introduction of recombinant nucleic acids and / or various forms of in vivo mutagenesis of native EPSPs genes), aroA genes and glyphosate acetyl transferase (GAT) genes, respectively). Resistance genes for other phosphono compounds include bar and pat genes from Streptomyces species, including Streptomyces hygroscopicus and Streptomyces viridichromogenes, and pyridinoxy or phenoxy proprionic acids and cyclohexones (ACCase inhibitor-encoding genes). Exemplary genes conferring resistance to cyclohexanediones and / or aryloxyphenoxypropanoic acid (including haloxyfop, diclofop, fenoxyprop, fluazifop, quizalofop) include genes of acetyl coenzyme A carboxylase (ACCase); Accl-Sl, Accl-S2 and Accl-S3. In an embodiment, herbicides can inhibit photosynthesis, including triazine (psbA and ls+ genes) or benzonitrile (nitrilase gene). Futhermore, such selectable markers can include positive selection markers such as phosphomannose isomerase (PMI) enzyme.

[0118] In an embodiment, selectable marker genes include, but are not limited to genes encoding: 2,4-D; neomycin phosphotransferase II; cyanamide hydratase; aspartate kinase; dihydrodipicolinate synthase; tryptophan decarboxylase; dihydrodipicolinate synthase and desensitized aspartate kinase; bar gene; tryptophan decarboxylase; neomycin phosphotransferase(NEO); hygromycin phosphotransferase (HPT or HYG); dihydrofolate reductase (DHFR); phosphinothricin acetyltransferase; 2,2-dichloropropionic acid dehalogenase; acetohydroxyacid synthase; 5-enolpyruvyl-shikimate-phosphate synthase (aroA); haloarylnitrilase; acetylcoenzyme A carboxylase; dihydropteroate synthase (sul I); and 32 kD photosystem II polypeptide (psbA). An embodiment also includes selectable marker genes encoding resistance to: chloramphenicol; methotrexate; hygromycin; spectinomycin; bromoxynil; glyphosate; and phosphinothricin. The above list of selectable marker genes is not meant to be limiting. Any reporter or selectable marker gene are encompassed by the present disclosure.

[0119] In some embodiments the coding sequences are synthesized for optimal expression in a plant. For example, in an embodiment, a coding sequence of a gene has been modified by codon optimization to enhance expression in plants. An insecticidal resistance transgene, an herbicide tolerance transgene, a nitrogen use efficiency transgene, a water use efficiency transgene, a nutritional quality transgene, a DNA binding transgene, or a selectable marker transgene / heterologous coding sequence can be optimized for expression in a particular plant species or alternatively can be modified for optimal expression in dicotyledonous or monocotyledonous plants. Plant preferred codons may be determined from the codons of highest frequency in the proteins expressed in the largest amount in the particular plant species of interest. In an embodiment, a coding sequence, gene, heterologous coding sequence or transgene / heterologous coding sequence is designed to be expressed in plants at a higher level resulting in higher transformation efficiency. Methods for plant optimization of genes are well known. Guidance regarding the optimization and production of synthetic DNA sequences can be found in, for example, WO2013016546, WO2011146524, WO1997013402, US Patent No. 6166302, and US Patent No. 5380831, herein incorporated by reference.

[0120] Transgenic events may be stacked with the 2,4-D resistance gene of the subject disclosure. Particularly useful transgenic events in transgenic plants or plant cultivars which can be utilized in the subject disclosure include Event 531 / PV-GHBK04 (cotton, insect control, described in W02002 / 040677), Event 1143-14A (cotton, insect control, not deposited, described in WO2006 / 128569); Event 1143-5 IB (cotton, insect control, not deposited, described in W02006 / 128570); Event 1445 (cotton, herbicide tolerance, not deposited, described in US-A 2002-120964 or W02002 / 034946); Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, described in WO2010 / 117737); Event 17314 (rice, herbicide tolerance, deposited as PTA-9844, described in WO2010 / 117735); Event 281-24-236 (cotton, insect control — herbicide tolerance, deposited as PTA-6233, described in W02005 / 103266 or US-A 2005-216969); Event3006-210-23 (cotton, insect control — herbicide tolerance, deposited as PTA-6233, described in US-A 2007-143876 orW02005 / 103266); Event 3272 (com, quality trait, deposited as PTA- 9972, described in W02006 / 098952 or US-A 2006-230473); Event 33391 (wheat, herbicide tolerance, deposited as PTA-2347, described in W02002 / 027004), Event 40416 (corn, insect control — herbicide tolerance, deposited as ATCC PTA-11508, described in WO 11 / 075593); Event 43A47 (corn, insect control — herbicide tolerance, deposited as ATCC PTA-11509, described in WO2011 / 075595); Event 5307 (corn, insect control, deposited as ATCC PTA-9561, described in W02010 / 077816); Event ASR-368 (bent grass, herbicide tolerance, deposited as ATCC PTA-4816, described in US-A 2006-162007 or W02004 / 053062); Event B16 (com, herbicide tolerance, not deposited, described in US-A 2003-126634); Event BPS-CV127 — 9 (soybean, herbicide tolerance, deposited as NCIMB No. 41603, described in W02010 / 080829); Event BLR1 (oilseed rape, restoration of male sterility, deposited as NCIMB 41193, described in W02005 / 074671), Event CE43-67B (cotton, insect control, deposited as DSM ACC2724, described in US-A 2009-217423 or WO2006 / 128573); Event CE44-69D (cotton, insect control, not deposited, described in US-A 2010-0024077); Event CE44-69D (cotton, insect control, not deposited, described in WO2006 / 128571); Event CE46-02A (cotton, insect control, not deposited, described in WO2006 / 128572); Event COT102 (cotton, insect control, not deposited, described in US-A 2006-130175 or W02004 / 039986); Event COT202 (cotton, insect control, not deposited, described in US-A 2007-067868 or W02005 / 054479); Event COT203 (cotton, insect control, not deposited, described in W02005 / 054480);); Event DAS21606-3 / 1606 (soybean, herbicide tolerance, deposited as PTA-11028, described in WO2012 / 033794), Event DAS40278 (corn, herbicide tolerance, deposited as ATCC PTA-10244, described in WO201 1 / 022469); Event DAS-44406-6 / pDAB8264.44.06.1 (soybean, herbicide tolerance, deposited as PTA-11336, described in WO2012 / 075426), Event DAS-14536- 7 / pDAB8291.45.36.2 (soybean, herbicide tolerance, deposited as PTA-11335, described in WO2012 / 075429), Event DAS-59122-7 (corn, insect control — herbicide tolerance, deposited as ATCC PTA 11384, described in US-A 2006-070139); Event DAS-59132 (corn, insect control — herbicide tolerance, not deposited, described in W02009 / 100188); Event DAS68416 (soybean, herbicide tolerance, deposited as ATCC PTA-10442, described in WO2011 / 066384 or WO201 1 / 066360); Event DP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA- 8296, described in US-A 2009-137395 or WO 08 / 112019); Event DP-305423-1 (soybean, quality trait, not deposited, described in US-A 2008-312082 or W02008 / 054747); Event DP- 32138-1 (com, hybridization system, deposited as ATCC PTA-9158, described in US-A 2009-0210970 or W02009 / 103049); Event DP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287, described in US-A 2010-0184079 or W02008 / 002872); Event EE-I (brinjal, insect control, not deposited, described in WO 07 / 091277); Event Fil 17 (corn, herbicide tolerance, deposited as ATCC 209031, described in US-A 2006-059581 or WO 98 / 044140); Event FG72 (soybean, herbicide tolerance, deposited as PTA-11041, described in WO201 1 / 063413), Event GA21 (corn, herbicide tolerance, deposited as ATCC 209033, described in US-A 2005-086719 or WO 98 / 044140); Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032, described in US-A 2005-188434 or W098 / 044140); Event GHB119 (cotton, insect control — herbicide tolerance, deposited as ATCC PTA-8398, described in W02008 / 151780); Event GHB614 (cotton, herbicide tolerance, deposited as ATCC PTA-6878, described in US-A 2010-050282 or W02007 / 017186); Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030, described in US-A 2005-188434 or W098 / 044140); Event GM RZ13 (sugar beet, virus resistance, deposited as NCIMB-41601, described in W02010 / 076212); Event H7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 or NCIMB 41159, described in US-A 2004-172669 or WO 2004 / 074492); Event JOPLIN1 (wheat, disease tolerance, not deposited, described in US-A 2008-064032); Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658, described in W02006 / 108674 or US-A 2008-320616); Event LL55 (soybean, herbicide tolerance, deposited as NCIMB 41660, described in WO 2006 / 108675 or US-A 2008-196127); Event LLcotton25 (cotton, herbicide tolerance, deposited as ATCC PTA-3343, described in W02003 / 013224 or US-A 2003-097687); Event LLRICE06 (rice, herbicide tolerance, deposited as ATCC 203353, described in U.S. Pat. No. 6,468,747 or W02000 / 026345); Event LLRice62 (rice, herbicide tolerance, deposited as ATCC 203352, described in W02000 / 026345), Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600, described in US-A 2008-2289060 or W02000 / 026356); Event LY038 (corn, quality trait, deposited as ATCC PTA-5623, described in US-A 2007-028322 or W02005 / 061720); Event MIR162 (corn, insect control, deposited as PTA-8166, described in US-A 2009-300784 or W02007 / 142840); Event MIR604 (com, insect control, not deposited, described in US-A 2008-167456 or W02005 / 103301); Event MON15985 (cotton, insect control, deposited as ATCC PTA-2516, described in US-A 2004-250317 or W02002 / 100163); Event MON810 (com, insect control, not deposited, described in US-A 2002-102582); Event MON863 (corn, insect control, deposited as ATCC PTA-2605, described in W02004 / 011601 or US-A 2006-095986); Event MON87427 (com, pollination control, deposited as ATCC PTA-7899, described in WO2011 / 062904); Event MON87460 (corn, stress tolerance, deposited as ATCCPTA-8910, described in W02009 / 111263 or US-A 2011-0138504); Event MON87701 (soybean, insect control, deposited as ATCC PTA-8194, described in US-A 2009-130071 or W02009 / 064652); Event MON87705 (soybean, quality trait — herbicide tolerance, deposited as ATCC PTA-9241, described in US-A 2010-0080887 or W02010 / 037016); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC PTA-9670, described in WO2011 / 034704); Event MON87712 (soybean, yield, deposited as PTA-10296, described in W02012 / 051199), Event MON87754 (soybean, quality trait, deposited as ATCC PTA-9385, described in W02010 / 024976); Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911, described in US-A 2011-0067141 or W02009 / 102873); Event MON88017 (corn, insect control — herbicide tolerance, deposited as ATCC PTA-5582, described in US-A 2008-028482 or W02005 / 059103); Event MON88913 (cotton, herbicide tolerance, deposited as ATCC PTA- 4854, described in W02004 / 072235 or US-A 2006-059590); Event MON88302 (oilseed rape, herbicide tolerance, deposited as PTA-10955, described in WO2011 / 153186), Event MON88701 (cotton, herbicide tolerance, deposited as PTA-11754, described in WO2012 / 134808), EventMon89034 (corn, insect control, deposited as ATCC PTA-7455, described in WO 07 / 140256 or US-A 2008-260932); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC PTA-6708, described in US-A 2006-282915 or W02006 / 130436); Event MSI 1 (oilseed rape, pollination control — herbicide tolerance, deposited as ATCC PTA-850 or PTA- 2485, described in W02001 / 031042); Event MS8 (oilseed rape, pollination control — herbicide tolerance, deposited as ATCC PTA-730, described in W02001 / 041558 or US-A 2003-188347); Event NK603 (corn, herbicide tolerance, deposited as ATCC PTA-2478, described in US-A 2007-292854); Event PE-7 (rice, insect control, not deposited, described in W02008 / 114282); Event RF3 (oilseed rape, pollination control — herbicide tolerance, deposited as ATCC PTA-730, described in W02001 / 041558 or US-A 2003-188347); Event RT73 (oilseed rape, herbicide tolerance, not deposited, described in W02002 / 036831 or US-A 2008-070260); Event SYHTOH2 / SYN-OOOH2-5 (soybean, herbicide tolerance, deposited as PTA-11226, described in WO2012 / 082548), Event T227-1 (sugar beet, herbicide tolerance, not deposited, described in W02002 / 44407 or US-A 2009-265817); Event T25 (com, herbicide tolerance, not deposited, described in US-A 2001-029014 or W02001 / 051654); Event T304-40 (cotton, insect control — herbicide tolerance, deposited as ATCC PTA-8171, described in US-A 2010-077501 or W02008 / 122406); Event T342-142 (cotton, insect control, not deposited, described in WO2006 / 128568); Event TC1507 (corn, insect control — herbicide tolerance, not deposited, described in US-A 2005-039226 or W02004 / 099447); Event VIP1034 (corn, insect control —herbicide tolerance, deposited as ATCC PTA-3925, described in W02003 / 052073), Event 32316 (corn, insect control-herbicide tolerance, deposited as PTA-11507, described inWO201 1 / 084632), Event 4114 (corn, insect control-herbicide tolerance, deposited as PTA- 11506, described in WO2011 / 084621), event EE-GM3 / FG72 (soybean, herbicide tolerance, ATCC Accession N° PTA-11041) optionally stacked with event EE-GM1 / LL27 or event EE- GM2 / LL55 (WO2011 / 063413A2), event DAS-68416-4 (soybean, herbicide tolerance, ATCC Accession N° PTA-10442, WO2011 / 066360A1), event DAS-68416-4 (soybean, herbicide tolerance, ATCC Accession N° PTA-10442, WO2011 / 066384A1), event DP-040416-8 (com, insect control, ATCC Accession N° PTA-11508, WO2011 / 075593A1), event DP-043 A47-3 (corn, insect control, ATCC Accession N° PTA-11509, WO2011 / 075595A1), event DP-004114- 3 (com, insect control, ATCC Accession N° PTA-11506, WO2011 / 084621 Al), event DP- 032316-8 (corn, insect control, ATCC Accession N° PTA-11507, WO2011 / 084632A1), event MON-88302-9 (oilseed rape, herbicide tolerance, ATCC Accession N° PTA-10955, WO201 1 / 153186A1), event DAS-21606-3 (soybean, herbicide tolerance, ATCC Accession No. PTA-11028, WO2012 / 033794A2), event MON-87712-4 (soybean, quality trait, ATCC Accession N°. PTA-10296, W02012 / 051199A2), event DAS-44406-6 (soybean, stacked herbicide tolerance, ATCC Accession N°. PTA-11336, WO2012 / 075426A1), event DAS-14536- 7 (soybean, stacked herbicide tolerance, ATCC Accession N°. PTA-11335, WO2012 / 075429A1), event SYN-000H2-5 (soybean, herbicide tolerance, ATCC Accession N°. PTA-11226, WO2012 / 082548A2), event DP-061061-7 (oilseed rape, herbicide tolerance, no deposit N° available, W02012071039A1), event DP-073496-4 (oilseed rape, herbicide tolerance, no deposit N° available, US2012131692), event 8264.44.06.1 (soybean, stacked herbicide tolerance, Accession N° PTA-11336, WO2012075426A2), event 8291.45.36.2 (soybean, stacked herbicide tolerance, Accession N°. PTA-11335, WO2012075429A2), event SYHTOH2 (soybean, ATCC Accession N°. PTA-11226, WO2012 / 082548A2), event MON88701 (cotton, ATCC Accession N° PTA-11754, WO2012 / 134808A1), event KK179-2 (alfalfa, ATCC Accession N° PTA-11833, W02013 / 003558A1), event pD AB 8264.42.32.1 (soybean, stacked herbicide tolerance, ATCC Accession N° PTA-11993, W02013 / 010094A1), event MZDT09Y (corn, ATCC Accession N° PTA-13025, WO2013 / 012775A1).

[0121] Transgenic events may be stacked with the 2,4-D resistance gene of the subject disclosure. Particularly useful transgenic events in transgenic plants or plant cultivars which can be utilized in the subject disclosure include transgenic events marketed as commercial products within the United States and listed in the following Table 2:Table 2: List of Transgenic Events

[0122] The described aspects and following examples are for illustrative purposes and are not intended to limit the scope of the claims. Other modifications, uses, or combinations with respect to the compositions described herein will be apparent to a person of ordinary skill in the art without departing from the spirit and scope of the claimed subject matter.EXAMPLESEVALUATION OF PESTICIDAL ACTIVITY

[0123] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Exemplified below in Table 3 is select herbicidal activity for some compounds on various weeds and crops.

[0124] The following Table 3 lists the growth stages of the plants at the time of application for the results exemplified in Table 4:Table 3: Plant Growth Stages at Time of Application

[0125] The following examples applied were technical grades, including control 2,4-D Isooctyl ester (CAS 25168-26-7), except for the 2,4-D choline, which was applied as the commercially available 2,4-D choline from Corteva Agriscience LLC under the tradename ENLIST ONE®. The technical grade materials were dissolved first in a 3 ml solvent mixture of 97.3% acetone: dimethyl sulfoxide (DMSO) and then diluted with a 17 ml solvent mixture of acetone, water, isopropyl alcohol, DMSO, Agri-Dex® crop oil concentrate (a heavy range,paraffin-based petroleum oil and nonionic emulsifiers commercially available from Rosecare) and nonionic Tergitol 1557 in a 40.3:45.3: 11.9: 1.3: 1.0:0.2 v / v ratio. All mix sizes were 20 ml.POSTEMERGENCE APPLICATION METHODS FOR HERBICIDE EVALUATIONS

[0126] Plants were grown in a soil media composed of 90% by volume Promix BX (Premier Tech Horticulture, Quakertown, PA) and 10% Profile Greens Grade (Profile Products LLC, Buffalo Grove, IL). Promix BX contains approximately 83% Sphagnum Peat Moss, 13% Perlite, 5% vermiculite, and proprietary amounts of limestone, starter fertilizer, and wetting agent. Profile Greens Grade is a sand-sized granule formed from calcining illite and montmorillonite clay. Several seeds of each species were planted in 10 cm square pots and top watered twice daily. Plant material was propagated in a warm greenhouse with temperature ranging from 25 to 28° C and 50 to 60% relative humidity at the Corteva Global Headquarters (Indianapolis, Indiana, USA). Natural light was supplemented with 1000-watt metal halide overhead lamps with an average illumination of 500 pE nr2s'1photosynthetic active radiation for 16 consecutive hours each day. Plants were top-watered prior to herbicide application and sub-watered after herbicide application.

[0127] Appropriate amounts of test materials were weighed out into glass vials in their technical form to deliver either 280 or 560 g acid equivalent (ae) / ha. The samples were dissolved in 3 ml of Solvent 1. Solvent 1 is 97% acetone and 3% dimethyl sulfoxide and serves as a general-purpose solvent (GPS) for dissolving technical materials. If samples did not readily dissolve, the sample bottles were placed in hot water and sonicated for 20 minutes. This typically resulted in the test material being thoroughly dissolved. The samples were then diluted to their final concentration using 17 ml of solvent 2 for a total of 20 ml of spray solution. Solvent 2 contains acetone, water, isopropyl alcohol, DMSO, Agri-Dex® crop oil concentrate (a heavy range, paraffin-based petroleum oil and nonionic emulsifiers commercially available from Rosecare) and nonionic Tergitol 1557 in a 40.3:45.3: 11.9: 1.3: 1.0:0.2 v / v ratio. All percentages are listed on a volume basis. 2,4-D choline as applied from the commercially available 2,4-D choline from Corteva Agriscience LLC under the tradename ENLIST ONE® and diluted with solvent 2 to compare all materials in the same spray solution.

[0128] Herbicide applications were made to 2 replicates of each plant species at the 4 to 8 leaf stage, depending on the species. Treatments were applied with a research track-sprayer (Generation III Research Sprayer manufactured by DeVries Manufacturing in Hollandale, MN, USA) calibrated to deliver a spray volume of 187 L / ha. The track-sprayer was fitted with an 8003E nozzle from Spray Systems Company (North Avenue and Schmale Road, P.O. Box 7900,Wheaton, IL 60187), and used a spray pressure of 276 kPa pressure and a speed of 3.1 km / h. The nozzle height was 46 cm above the plant canopy. The experimental design used for the trials was a randomized complete block with 2 replications per treatment. After application, plants were placed on carts according to the randomization and returned to the greenhouse. Plants were sub-watered after treatment with Indianapolis city water or fertilized three times a week with a commercial fertilizer solution (Jack’s Professional 15-5-15 4 Ca 2Mg fertilizer (manufactured by JR PETERS INC., 6656 Grant Way, Allentown, PA 18106; www.jrpeters.com). Percent visual control assessments were made on a scale of 0 to 100% (where 0 was no control and 100 was complete plant death) at 7, 14, and 21 days after treatment.Measuring the effect of representative experimental compounds on the growth of Amaranthus rudis.

[0129] In conformity with the methods outlined above in Postemergence Application Methods for Herbicide Evaluations, the effect of representative experimental compounds on the growth of Amaranthus rudis (AMATA), common name tall water hemp, was determined at 2 different levels (respectively, 280 and 560 g acid equivalent (ae) / ha) of the experimental actives tested. Plants were treated with one of the compounds, a control plant was not treated. Twenty- one days after treatment, the plants were measured. The data is present as a percent reduction in plant size relative to the untreated control. Referring now to Table 4, some of the compounds tested demonstrated a significant effect on the growth of this common species of weed.Measuring the effect of representative experimental compounds on the growth of Ambrosia artemisiifolia

[0130] In conformity with the methods outlined above in Postemergence Application Methods for Herbicide Evaluations, the effect of representative experimental compounds on the growth of Ambrosia artemisiifolia (AMBEL), (common ragweed), was determined at 2 different levels (respectively, 280 and 560 g acid equivalent (ae) / ha) of the experimental actives tested. Plants were treated with one of the compounds, a control plant was not treated. Twenty-one days after treatment, the plants were measured. The data is present as a percent reduction in plant size relative to the untreated control. Referring now to Table 5, some of the compounds tested demonstrated a significant effect on the growth of this common species of weed.Measuring the effect of representative experimental compounds on the growth of Abutilon theophrasti

[0131] In conformity with the methods outlined above in Postemergence Application Methods for Herbicide Evaluations, the effect of representative experimental compounds on thegrowth of Abutilon theophrasti (ABUTH), common name velvetleaf, was determined at 2 different levels (respectively, 280 and 560 g acid equivalent (ae) / ha) of the experimental actives tested. Plants were treated with one of the compounds, a control plant was not treated. Twenty- one days after treatment, the plants were measured. The data is present as a percent reduction in plant size relative to the untreated control. Referring now to Table 4, some of the compounds tested demonstrated a significant effect on the growth of this common species of weed.Measuring the effect of representative experimental compounds on the growth of Chenopodium album

[0132] In conformity with the methods outlined above in Postemergence Application Methods for Herbicide Evaluations, the effect of representative experimental compounds on the growth of Chenopodium album (CHEAL), common name, common lambsquarters, was determined at two different levels (respectively, 280 and 560 g acid equivalent (ae) / ha) of the experimental actives tested. Plants were treated with one of the compounds, a control plant was not treated. Twenty-one days after treatment, the plants were measured. The data is present as a percent reduction in plant size relative to the untreated control. Referring now to Table 4, some of the compounds tested demonstrated a significant effect on the growth of this common species of weed.Measuring the effect of representative experimental compounds on the growth of Conyza canadensis (L.)

[0133] In conformity with the methods outlined above in Postemergence Application Methods for Herbicide Evaluations, the effect of representative experimental compounds on the growth of Conyza canadensis (L.), (ERICA), common name, Horseweed, was determined at 2 different levels (respectively, 280 and 560 g acid equivalent (ae) / ha) of the experimental actives tested. Plants were treated with one of the compounds, a control plant was not treated. Twenty- one days after treatment, the plants were measured. The data is present as a percent reduction in plant size relative to the untreated control. Referring now to Table 4, some of the compounds tested demonstrated a significant effect on the growth of this common species of weed.Measuring the effect of representative experimental compounds on the growth of Glycine max

[0134] In conformity with the methods outlined above in Postemergence Application Methods for Herbicide Evaluations, the effect of representative experimental compounds on the growth of 2,4-D resistant Glycine max was determined at 2 different levels (respectively, 280 and 560 g acid equivalent (ae) / ha) of the experimental actives tested. Plants were treated withone of the compounds, a control plant was not treated. Twenty-one days after treatment, the plants were measured. The data is present as a percent reduction in plant size relative to the untreated control.Table 4: Average Effect of Representative Compounds on the Growth of Exemplary PlantsOTHER PESTICIDES

[0135] Some aspects of the disclosed safened compositions disclosed include adding one or more additional pesticide active ingredients to the safened compositions. These pesticide active ingredients may include one or more of an herbicide, an insecticide, a fungicide, a nematocide, a miticide, a arthropodicide, a bactericide, a plant growth regulator, or combinations thereof that are compatible with the compositions of the present disclosure.

[0136] In some aspects, the additive is an additional herbicide. For example, the compositions described herein can be applied in conjunction with one or more additional herbicides to control undesirable vegetation. The composition can be formulated with the one or more additional herbicides, tank mixed with the one or more additional herbicides, or applied sequentially with the one or more additional herbicides, such as the exemplary herbicides described below.

[0137] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an acetolactate synthase (ALS) inhibitor at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. Examples of ALS inhibitors include sulfonylureas, imidazolinones, triazolopyrimidine sulfonamides, pyrimidinyl oxybenzoates and sulfonylaminocarbonyl triazolinones. In some aspects, the ALS inhibitor can contain a triazolopyrimidine sulfonamide herbicide. In some aspects, the ALS inhibitor can contain an imidazolinone herbicide. In some aspects, the ALS inhibitor can contain a pyrimidinyl oxybenzoate herbicide. In some aspects, the ALS inhibitor can contain a sulfonylaminocarbonyl triazolinone herbicide. In some aspects, the ALS inhibitor can contain a sulfonylurea herbicide.

[0138] In some aspects, the composition can include an ALS inhibitor selected from the group of imidazolinones, triazolopyrimidine sulfonamides, pyrimidinyl oxybenzoates, sulfonylaminocarbonyl triazolinones, sulfonylureas, and combinations thereof. In some cases, the composition can include amidosulfuron, azimsulfuron, bispyribac, bensulfuron, chlorimuron, chlorsulfuron, cinosulfuron, cloransulam, cyclosulfamuron, diclosulam, ethametsulfuron, ethoxysulfuron, flazasulfuron, florasulam, flucarbazone, flucetosulfuron, flumetsulam, flupyrsulfuron, foramsulfuron, halosulfuron, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, iodosulfuron, iofensulfuron, mesosulfuron, metazosulfuron, metosulam, metsulfuron, nicosulfuron, orthosulfamuron, oxasulfuron, penoxsulam, primisulfuron, propoxycarbazone, propyrisulfuron, prosulfuron, pyrazosulfuron, pyribenzoxim, pyriftalid, pyriminobac, pyrimisulfan, pyrithiobac, pyroxsulam, rimsulfuron,sulfometuron, sulfosulfuron, thiencarb azone, thifensulfuron, triasulfuron, tribenuron, trifloxysulfuron, triflusulfuron, tritosulfuron, agriculturally acceptable salts and esters thereof, and combinations thereof.

[0139] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Triazolopyrimidine Sulfonamide Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I , and (b) florasulam, cloransulam, diclosulam, flumetsulam, metosulam, penoxsulam, or pyroxsulam, or agriculturally acceptable salts or esters thereof.

[0140] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Imidazolinone Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I , and (b) imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, or agriculturally acceptable salts or esters thereof, or combinations thereof.

[0141] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Pyrimidinyl Oxybenzoate Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I , and (b) bispyribac, pyribenzoxim, pyriftalid, pyriminobac, pyrimisulfan, pyrithiobac, or agriculturally acceptable salts or esters thereof, or combinations thereof.

[0142] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Sulfonylaminocarbonyl Triazolinone Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I , and (b) flucarbazone, propoxycarbazone, thiencarb azone, or agriculturally acceptable salts or esters thereof, or combinations thereof.

[0143] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Sulfonylurea Herbicide atappropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains a herbicidally effective amount of compounds according to Formula I , and (b) amidosulfuron, azimsulfuron, bensulfuron, chlorimuron, chlorsulfuron, cinosulfuron, cyclosulfamuron, ethametsulfuron, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, foramsulfuron, halosulfuron, imazosulfuron, iodosulfuron, iofensulfuron, mesosulfuron, metazosulfuron, metsulfuron, nicosulfuron, orthosulfamuron, oxasulfuron, primisulfuron, propyrisulfuron, prosulfuron, pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, triasulfuron, tribenuron, thifensulfuron, trifloxysulfuron, triflusulfuron, tritosulfuron, or agriculturally acceptable salts or esters thereof, or combinations thereof.

[0144] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Synthetic Auxin Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. Synthetic auxin herbicides mimic natural plant hormones and can inhibit cell division and growth. Synthetic auxin herbicides include phenoxy herbicides, benzoic acid herbicides, aryl picolinate herbicides, compounds according to Formula Is, quinoline carboxylic acid herbicides, pyrimidine carboxylic acid herbicides, and benzothiazole herbicides, as well as agriculturally acceptable salts and esters thereof. In some aspects, the composition can include a synthetic auxin herbicide selected from the group consisting of 2,4-D; 2,4-DB; 2,3,6-TBA, aminocyclopyrachlor, aminopyralid, benazolin-ethyl, chloramben, clomeprop, clopyralid, dichlorprop, dichlorprop-P, dicamba, florpyrauxifen (such as florpyrauxifen-benzyl), fluchloraminopyr (e.g., fluchloraminopyr- tefuryl), fluroxypyr, fluroxypyr-MHE, halauxifen (such as halauxifen-methyl), indolauxipyr (such as indolauxipyr-cyanomethyl), mecoprop, mecoprop-P, MCPA, MCPA-thioethyl, MCPB, picloram, quinclorac, quinmerac, triclopyr, agriculturally acceptable salts and esters thereof, and combinations thereof. In some aspects, the synthetic auxin herbicide can comprise 2,4-D, MCPA, aminopyralid, clopyralid, dicamba, florpyrauxifen, fluroxypyr, halauxifen, quinclorac, agriculturally acceptable salts and esters thereof, and combinations thereof.

[0145] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Phenoxy carboxylic Acid Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, thecomposition contains compounds according to Formula I , and (b) 2,4-D, 2,4-DB2, clomeprop, dichlorprop, mecoprop, MCPA, MCPB, or agriculturally acceptable salts or esters thereof.

[0146] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Benzoic Acid Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains compounds according to Formula I , and (b) chloramben, dicamba, TBA, or agriculturally acceptable salts or esters thereof.

[0147] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Aryl Picolinate Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains compounds according to Formula I , and (b) florpyrauxifen, halauxifen, or agriculturally acceptable salts or esters thereof.

[0148] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Quinoline Carboxylic Acids Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains compounds according to Formula I , and (b) quinclorac, quinmerac, or agriculturally acceptable salts or esters thereof.

[0149] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Synthetic Auxin Herbicides at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In some aspects, the composition contains compounds according to Formula I , and (b) aminocyclopyrachlor, benazolin, or agriculturally acceptable salts or esters thereof.

[0150] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Auxin Transport Inhibitor Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition, the pyridine carboxylic acid herbicide or agriculturally acceptable N-oxide, salt or ester thereof, the compositions can include an auxin transport inhibitor. Auxin transport inhibitors inhibit polar transport of naturally occurring auxin, indole acetic acid (IAA), and synthetic auxin-mimickingherbicides in sensitive plants. Examples of auxin transport inhibitors include phthalamate herbicides, semicarbazone herbicides and others. In some aspects, the composition can include an auxin transport inhibitor selected from the group consisting of: chlorflurenol; diflufenzopyr; naptalam; 2,3,5-triiodobenzoic acid (2,3,5-TIBA); agriculturally acceptable salts and esters thereof; and combinations thereof.

[0151] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an PPO Inhibitor Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I of Formula (I), or agriculturally acceptable N-oxide, salt, or ester thereof, the compositions can include an inhibitor of a protoporphyrinogen oxidase (PPO), which is an enzyme involved in the biosynthesis of both heme and chlorophyll. It is believed that PPO inhibitors generate large amounts of singlet oxygen, which leads to the peroxidation of the lipids in cell membranes. Examples of PPO inhibitors include acifluorfen, azafenidin, benzfendizone, bifenox, butafenacil, carfentrazone, chlomethoxyfen, cinidon, fluazolate, flufenpyr, flumiclorac, flumioxazin, fluoroglycofen, fluthiacet, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazon, oxyfluorfen, pentoxazone, profluazol, pyraclonil, pyraflufen, saflufenacil, sulfentrazone, thidiazimin, tiafenacil, trifludimoxazin, ethyl [3-[2-chloro-4-fluoro-5-(l-methyl-6- trifluoromethyl-2,4-dioxo-l,2,3,4-tetrahydropyrimidin-3-yl)phenoxy]-2-pyridyloxy]acetate (CAS 353292-31-6; S-3100), N-ethyl-3-(2,6-dichloro-4-trifluoromethylphenoxy)-5-methyl-lH- pyrazole-1- carboxamide (CAS 452098-92-9), N-tetrahydrofurfuryl-3-(2,6-dichloro-4- trifluoromethylphenoxy)-5-methyl- l -H-pyrazole- l -carboxamide (CAS 915396-43-9), N-ethyl-3- (2-chloro-6-fluoro-4-trifluoromethylphenoxy)-5-methyl-lH-pyrazo-le-l -carboxamide (CAS 452099-05-7), N-tetrahydrofurfuryl-3-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)-5-methyl- IH-pyrazole-l -carboxamide (CAS 45100-03-7), 3-[7-fhroro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro- 2H-benzo[l, 4]oxazin-6-yl]-l,5-dimethyl-6-thioxo[l, 3, 5]triazinan-2, 4-dione, agriculturally acceptable esters thereof, or combinations thereof.

[0152] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an PDS Inhibitor Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I, the compositions can include a phytoene desaturase (PDS) inhibitor herbicide or agriculturally acceptable salt or ester thereof. PDS inhibitors blockcarotenoid biosynthesis by inhibition of phytoene desaturase, a key enzyme in the carotenoid biosynthesis pathway. An absence of carotenoids leads to destruction of membrane fatty acid and chlorophyll by excessive energy. Examples of PDS inhibitors include, but are not limited to, beflubutamid, diflufenican, fluridone, flurochloridone, flurtamone, norflurazon, and picolinafen.

[0153] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Glyphosate or Glufosinate Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I, the compositions can include glyphosate, glufosinate, an agriculturally acceptable salt thereof, or mixtures thereof. In some aspects, compositions and methods of the present disclosure can include glyphosate or an agriculturally acceptable salt thereof. Glyphosate, as well as methods of preparing glyphosate, are known in the art.

[0154] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Photosystem II Inhibitor Herbicides at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I, the compositions can include a photosystem II (PS II) inhibitor herbicide or agriculturally acceptable salt or ester thereof. Photosystem II inhibitors inhibit photosynthesis by binding to the photosystem II complex in the chloroplast. Examples of photosystem II inhibitors include phenylcarbamate herbicides, pyridazinone herbicides, triazolinone herbicides, triazine herbicides, urea herbicides, uracil herbicides, amide herbicides, nitrile herbicides, and phenylpyridazine herbicides.

[0155] In some aspects, the composition can include a PS II inhibitor herbicide selected from the group consisting of ametryne, amicarbazone, atrazine, bentazone, bromacil, bromofenoxim, bromoxynil, chlorbromuron, chloridazon, chlorotoluron, chloroxuron, cyanazine, desmedipham, desmetryn, dimefuron, dimethametryn, diuron, ethidimuron, ethiozin, fenuron, fluometuron, hexazinone, iodobonil, ioxynil, isocil, isomethiozin, isoproturon, isouron, karbutilate, lenacil, linuron, metamitron, methabenzthiazuron, metobromuron, metoxuron, metribuzin, monolinuron, neburon, pentanochlor, phenmedipham, prometon, prometryn, propanil, propazine, pyridafol, pyridate, siduron, simazine, simetryne, tebuthiuron, terbacil, terbumeton, terbuthylazine, terbutryn, trietazine, and combinations thereof.

[0156] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an 4-hydroxyphenyl-pyruvatedioxygenase (HPPD) inhibitor herbicide. at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. Examples of HPPD inhibitors include benzobicyclon, benzofenap, bicyclopyrone, fenquinotrione, isoxachlortole, isoxaflutole, lancotrione, mesotrione, pyraquinate, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, tolpyralate, topramezone, or an agriculturally acceptable salt or ester thereof, and combinations thereof.

[0157] In some aspects, the composition can include a HPPD inhibitor herbicide selected from the group consisting of benzobicyclon, benzofenap, bicyclopyrone, fenquinotrione, isoxachlortole, isoxaflutole, lancotrione, mesotrione, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, tolpyralate, topramezone, an agriculturally acceptable salt or ester thereof, and combinations thereof.

[0158] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an ACCase Inhibitor Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I or agriculturally acceptable N-oxide, salt or ester thereof, the compositions include an acetyl CoA carboxylase (ACCase) inhibitor herbicide or an agriculturally acceptable salt or ester thereof. ACCase inhibitor herbicides inhibit lipid biosynthesis in the plant. Examples of ACCase inhibitor herbicides include aryloxyphenoxypropionates, cyclohexanediones, and phenylpyrazolines. In some aspects, the ACCase inhibitor herbicide can include an aryloxyphenoxypropionate herbicide. In some aspects, the ACCase inhibitor herbicide can include a cyclohexanedione herbicide. In some aspects, the ACCase inhibitor herbicide can include a phenylpyrazoline herbicide.

[0159] In some aspects, the composition can include an ACCase inhibitor selected from the group of cyclohexanediones, aryloxyphenoxypropionates, phenylpyrazolines, or combinations thereof. In some cases, the composition can include clodinafop, cyhalofop, diclofop, fenoxaprop, fenthiaprop, fluazifop, haloxyfop, metamifop, propaquizafop, quizalofop, agriculturally acceptable salts or esters thereof, or combinations thereof. In some cases, the composition can include, alloxydim, butroxydim, clethodim, cloproxydim, cycloxydim, profoxydim, pyriflubenzoxim, sethoxydim, tepraloxydim, tralkoxydim, agriculturally acceptable salts or esters thereof, or combinations thereof. In some cases, the composition can include pinoxaden

[0160] In some aspects, the composition can include an ACCase inhibitor herbicide selected from the group consisting of alloxydim, butroxydim, clethodim, clodinafop, cloproxydim, cycloxydim, cyhalofop, diclofop, fenoxaprop, fenthiaprop, fluazifop, haloxyfop, metamifop, pinoxaden, profoxydim, propaquizafop, quizalofop, sethoxydim, tepraloxydim, alkoxide, agriculturally acceptable salts and esters thereof, and combinations thereof.

[0161] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include a Plant Growth Regulator Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I or agriculturally acceptable N-oxide, salt or ester thereof, the compositions can include a plant growth regulator (PGR), an agriculturally acceptable salt or ester thereof, or mixtures thereof. PGRs, also called plant hormones, act as chemical messengers for intercellular communication. PGRs can be classified into a number of modes of action that may influence, for example, the growth, division, elongation, or differentiation of plant cells. Examples of PGRs include 1,4-dimethylnapththalene, 1 -methylcyclopropene, 1-napthylacetic acid, 2,6-diisopropylnaphthalene, 2-naphthyloxyacetic acid, 4-chlorophenoxyacetic acid (4- CPA), 6-benzylaminopurine, abscisic acid, amidochlor, ancymidol, aviglycine, butralin, carbaryl, chlorflurenol, chlormequat, chlorphonium chloride, chlorpropham, clofencet, cloprop, cloxyfonac, cuprous chloride, cyanamide, cyclanilide, cycloheximide, cytokinins, daminozide, decan- l-ol, dikegulac, dimethipin, dimexano, endothal, etacelasil, ethephon, ethychlozate, fenoprop, fenridazon, flumetralin, flurenol, flurprimidol, forchlorfenuron, gibberellins, glyphosine, heptamaloxyloglucan, heptopargil, hexafluoroacetone trihydrate, inabenfide, indol- 3 -butyric acid (IB A), indol-3-ylacetic acid (IAA), isoprothiolane, maleic hydrazide, mefluidide, mepiquat, N-acetylthiazolidine-4-carboxylic acid, naphthaleneacetamide, N-m-tolylphthalamic acid, N-phenylphthalamic acid, nitrophenolates, paclobutrazol, pelargonic acid, piproctanyl bromide, prohexadione, prohydrojasmon, propham, propyl-3-tert-butylphenoxyacetate, sintofen, tetcyclacis, thidiazuron, triacontanol, triapenthenol, trinexapac, and uniconazole.

[0162] In some aspects, the composition can include a PGR selected from the group consisting of 1,4-dimethylnapththalene, 1 -methylcyclopropene, 1-napthylacetic acid, 2,6- diisopropylnaphthalene, 2-naphthyloxyacetic acid, 4-chlorophenoxyacetic acid (4-CPA), 6- benzylaminopurine, abscisic acid, amidochlor, ancymidol, aviglycine, butralin, carbaryl, chlorflurenol, chlormequat, chlorphonium chloride, chlorpropham, clofencet, cloprop, cloxyfonac, cuprous chloride, cyanamide, cyclanilide, cycloheximide, cytokinins, daminozide,decan- l-ol, dikegulac, dimethipin, dimexano, endothal, etacelasil, ethephon, ethychlozate, fenoprop, fenridazon, flumetralin, flurenol, flurprimidol, forchlorfenuron, gibberellins, glyphosine, heptamaloxyloglucan, heptopargil, hexafluoroacetone trihydrate, inabenfide, indol- 3 -butyric acid (IB A), indol-3-ylacetic acid (IAA), isoprothiolane, maleic hydrazide, mefluidide, mepiquat, N-acetylthiazolidine-4-carboxylic acid, naphthaleneacetamide, N-m-tolylphthalamic acid, N-phenylphthalamic acid, nitrophenolates, paclobutrazol, pelargonic acid, piproctanyl bromide, prohexadione, prohydrojasmon, propham, propyl-3-tert-butylphenoxyacetate, sintofen, tetcyclacis, thidiazuron, triacontanol, triapenthenol, trinexapac, uniconazole, agriculturally acceptable salts or esters thereof, and mixtures thereof.

[0163] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an ACCase Inhibitor Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I or agriculturally acceptable N-oxide, salt or ester thereof, the compositions include an acetyl CoA carboxylase (ACCase) inhibitor herbicide or an agriculturally acceptable salt or ester thereof. ACCase inhibitor herbicides inhibit lipid biosynthesis in the plant. Examples of ACCase inhibitor herbicides include aryloxyphenoxypropionates, cyclohexanediones, and phenylpyrazolines. In some aspects, the ACCase inhibitor herbicide can include an aryloxyphenoxypropionate herbicide. In some aspects, the ACCase inhibitor herbicide can include a cyclohexanedione herbicide. In some aspects, the ACCase inhibitor herbicide can include a phenylpyrazoline herbicide.

[0164] In some aspects, the composition can include an ACCase inhibitor selected from the group of cyclohexanediones, aryloxyphenoxypropionates, phenylpyrazolines, or combinations thereof. In some cases, the composition can include clodinafop, cyhalofop, diclofop, fenoxaprop, fenthiaprop, fluazifop, haloxyfop, metamifop, propaquizafop, quizalofop, agriculturally acceptable salts or esters thereof, or combinations thereof. In some cases, the composition can include, alloxydim, butroxydim, clethodim, cloproxydim, cycloxydim, profoxydim, sethoxydim, tepraloxydim, tralkoxydim, agriculturally acceptable salts or esters thereof, or combinations thereof. In some cases, the composition can include pinoxaden

[0165] In some aspects, the composition can include an ACCase inhibitor herbicide selected from the group consisting of alloxydim, butroxydim, clethodim, clodinafop, cloproxydim, cycloxydim, cyhalofop, diclofop, fenoxaprop, fenthiaprop, fluazifop, haloxyfop, metamifop,pinoxaden, profoxydim, propaquizafop, quizalofop, sethoxydim, tepraloxydim, tralkoxydim, agriculturally acceptable salts and esters thereof, and combinations thereof.

[0166] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an VLCFA Synthesis Inhibitor Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I or agriculturally acceptable N-oxide, salt or ester thereof, the compositions include a very long chain fatty acid (VLCFA) synthesis inhibitor herbicide. Very long chain fatty acids have multiple functions in the plant, primarily serving as precursors of cuticle wax biosynthesis, and as components of storage lipids, sphingolipids and phospholipids. Examples of VLCFA synthesis inhibitors include, but are not limited to, acetochlor, alachlor, anilofos, butachlor, cafenstrole, dimethachlor, dimethenamid, diphenamid, fentrazamide, flufenacet, ipfencarbazone, mefenacet, metazachlor, metolachlor, naproanilide, napropamide, pethoxamid, piperophos, pretilachlor, propachlor, propisochlor, pyroxasulfone, and thenylchlor.

[0167] In some aspects, the composition can include a VLCFA synthesis inhibitor herbicide selected from the group consisting of acetochlor, alachlor, anilofos, butachlor, cafenstrole, dimethachlor, dimethenamid, diphenamid, fentrazamide, flufenacet, ipfencarbazone, mefenacet, metazachlor, metolachlor, naproanilide, napropamide, pethoxamid, piperophos, pretilachlor, propachlor, propisochlor, pyroxasulfone, thenylchlor, agriculturally acceptable salts and esters thereof, and combinations thereof.

[0168] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Microtubule Assembly Inhibitor (MAI) Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety.

[0169] In addition to the compounds according to Formula I or agriculturally acceptable N- oxide, salt or ester thereof, the compositions can include a microtubule assembly inhibitor (MAI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. MAI herbicides may inhibit plant cell division by binding to tubulin, the major protein needed to form the microtubules required in cell division.

[0170] Examples of MAI herbicides include benfluralin, butamifos, butralin, carbetamide, chlorpropham, chlorthal, dithiopyr, ethalfluralin, oryzalin, pendimethalin, prodiamine, propham, propyzamide, thiazopyr, trifluralin, and agriculturally acceptable salts or esters thereof.

[0171] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Fatty Acid and Lipid Synthesis Inhibitor (FA / LSI) Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety. In addition to the compounds according to Formula I or agriculturally acceptable N- oxide, salt or ester thereof, the compositions can include a fatty acid and lipid synthesis inhibitor (FA / LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. FA / LSI herbicides appear to interfere with the biosynthesis of fatty acids and lipids, thereby reducing the deposition of cuticle wax, and to cause abnormal cell development or to inhibit cell division in germinating seedlings. Examples of FA / LSI herbicides include benfuresate, bensulide, butylate, cycloate, dalapon, EPTC, esprocarb, ethofumesate, flupropanate, molinate, orbencarb, prosulfocarb, thiobencarb, tiocarbazil, tri-allate, vernolate.

[0172] In some aspects, the composition can include a FA / LSI herbicide selected from the group consisting of benfuresate, bensulide, butylate, cycloate, dalapon, EPTC, esprocarb, ethofumesate, flupropanate, molinate, orbencarb, prosulfocarb, thiobencarb, tiocarbazil, tri- allate, vernolate, agriculturally acceptable salts or esters thereof, and mixtures thereof.

[0173] Those with skill in the art would appreciate that in addition to the compounds according to Formula I of Table 1, the compositions can include an Broclozone, Flusulfmam, Icafolin, Iptriazopyrid or a Metproxybicyclone Herbicide at appropriate working concentrations as described in International Patent Publication No. PCT / US2023 / 071586, herein incorporated by reference in its entirety.Exemplification of Mixture Herbicidal Activity

[0174] The following Table lists the growth stages of the plants at the time of application for the results exemplified in this application:Table 2: Growth Stages of Plants For Results Exemplified

[0175] All 2,4-D pro herbicide analogs and trifludimaxazin were applied in their technical form. Appropriate amounts of the technical grade materials were dissolved first in solvent 1, a mixture of 97.3% acetone: dimethyl sulfoxide (DMSO). The appropriate amount of 2,4-D proherbicide required to spray all treatments in each trial was weighed out and dissolved in solvent 1 to create a stock solution. If samples did not readily dissolve, the sample bottles were placed in hot water and sonicated for 20 minutes. Additionally, the samples were kept in hot water until sprayed. This resulted in the test material being thoroughly dissolved. Aliquots of the stock solution were measured out to provide the quantity needed for each treatment on an acid equivalent basis for all 2,4-D pro-herbicide concepts and glyphosate. The volume of stock solution and amount of any mixing partner was calculated and subtracted from 30. This difference was added to the spray bottle with solvent mixture 2, a mix of acetone, water, isopropyl alcohol, DMSO, Agri-Dex® crop oil concentrate (a heavy range, paraffin-based petroleum oil and nonionic emulsifiers commercially available from Rosecare) and nonionic Tergitol 1557 in a 40.3:45.3: 11.9: 1.3: 1.0:0.2 % v / v ratio. All percentages are listed on a volume basis. Lastly the required amount of mixing partner was added to the spray bottle. Collectively these additions resulted in a mix size of 30 ml.

[0176] The following mixing partners used in these trials were applied in their formulated form: saflufenacil under the tradename SHARPEN®, 341.5 g ai / L suspension concentrate (SC), sulfentrazone under the tradename SPRATAN® 4F, 480 g ai / L suspension concentrate (SC), glyphoste-K salt under the tradename ROUNDUP POWERMAX® 3, 575 g ae / L soluble liquid (SL), glufosinate under the tradename LIBERTY® 280 SL, 280 g ai / L soluble liquid (SL), diclosulam under the tradename STRONGARM®, 840 g ai / KG water dispersible granule (WDG), Arylex under the tradename ELEVORE®, 68.5 g ai / L soluble liquid (SL), mesotrione under the tradename CALLISTO®, 420 g ai / L suspension concentrate (SC).

[0177] Appropriate amounts of all liquid formulated herbicides were measured out and added directly to the spray bottle. Diclosulam was formulated as a WDG, and the amount required for all treatments in a trial was measured out and dissolved in water to create a stock solution. Aliquots of the stock solution were measured out to provide the quantity needed for each treatment.

[0178] Plants were grown in a soil media composed of 90% by volume Promix BX (Premier Tech Horticulture, Quakertown, PA) and 10% Profile Greens Grade (Profile Products LLC, Buffalo Grove, IL). Promix BX contains approximately 83% Sphagnum Peat Moss, 13% Perlite, 5% vermiculite, and proprietary amounts of limestone, starter fertilizer, and wettingagent. Profile Greens Grade is a sand-sized granule formed from calcining illite and montmorillonite clay. Several seeds of each species were planted in 10 cm square pots and top watered twice daily. Plant material was propagated in a warm greenhouse with temperature ranging from 25 to 28° C and 50 to 60% relative humidity at the Corteva Global Headquarters (Indianapolis, Indiana, USA). Natural light was supplemented with 1000-watt metal halide overhead lamps with an average illumination of 500 pE nr2s'1photosynthetic active radiation for 16 consecutive hours each day. Plants were top-watered prior to herbicide application and sub-watered after herbicide application.

[0179] Herbicide applications were made to 3 replicates of each plant species at the 3 to 8 leaf stage, depending on the species. Treatments were applied with a research track-sprayer (Generation III Research Sprayer manufactured by DeVries Manufacturing in Hollandale, MN, USA) calibrated to deliver a spray volume of 200 L / ha. The track-sprayer was fitted with an 8003E nozzle from Spray Systems Company (North Avenue and Schmale Road, P.O. Box 7900, Wheaton, IL 60187), and used a spray pressure of 276 kPa pressure and a speed of 3.1 km / h. The nozzle height was 46 cm above the plant canopy. The experimental design used for the trials was a randomized complete block with 3 replications per treatment. After application, plants were placed on carts according to the randomization and returned to the greenhouse. Plants were sub-watered after treatment with Indianapolis city water or fertilized three times a week with a commercial fertilizer solution (Jack’s Professional 15-5-15 4 Ca 2Mg fertilizer (manufactured by JR PETERS INC., 6656 Grant Way, Allentown, PA 18106; www.jrpeters.com). Percent visual control assessments were made on a scale of 0 to 100% (where 0 was no control and 100 was complete plant death) at 14 and 21 days after application.

[0180] Table 3: Treatments Applied in Trial 1

[0181] Table 4: Treatments Applied in Trial 2

[0182] Table 5: Treatments Applied in Bridging Trial 1

[0183] Table 6: Treatments Applied in Bridging Trial 2

[0184] Table 7: Treatments Applied in Bridging Trial 3

[0185] Table 11: Mixture Trials ResultsEVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE TO THE COMPOSITIONS PROVIDED INTABLE 1

[0186] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0187] Herbicide resistance tests of the compositions provided in Table 1 are completed in com plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type corn plants. Corn plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21,24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) are produced using art known plant transformation methods and confirmed via molecular introgression studies. Next, com plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), control nucleotide sequences and wild type corn plants are grown up and spayed with the herbicide compositions provided in Table 1 at varying concentrations. The corn plants are visually assessed once per week for three weeks after herbicide application for the percentage of corn plants killed or showing severe herbicide-related injury (where 0% represents no activity and 100% represents death of all target com plants). The results indicate that the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), confer resistance against herbicide compositions provided in Table 1. Comparatively, none of the wild type corn plants or com plants with control sequences show high levels of resistance against the herbicide compositions provided in Table 1.

[0188] Herbicide resistance tests of the compositions provided in Table 1 are completed in soybean plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type soybean plants. Soybean plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) are produced using art known plant transformation methods and confirmed via molecular introgression studies. Next, soybean plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), control nucleotide sequences and wild type soybean plants are grown up and spayed with the herbicide compositions provided in Table 1 at varying concentrations. The soybean plants are visually assessed once per week for three weeks after herbicide application for the percentage of soybean plants killed or showing severe herbicide-related injury (where 0% represents no activity and 100% represents death of all target soybean plants). The results indicate that the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), confer resistance against herbicide compositions provided in Table 1. Comparatively, none of the wild type soybean plants or soybean plants with control sequences show high levels of resistance against the herbicide compositions provided in Table 1.

[0189] Herbicide resistance tests of the compositions provided in Table 1 are completed in cotton plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type cotton plants. Cotton plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) are produced using art known plant transformation methods and confirmed via molecular introgression studies. Next, cotton plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), control nucleotide sequences and wild type cotton plants are grown up and spayed with the herbicide compositions provided in Table 1 at varying concentrations. The cotton plants are visually assessed once per week for three weeks after herbicide application for the percentage of cotton plants killed or showing severe herbicide-related injury (where 0% represents no activity and 100% represents death of all target cotton plants). The results indicate that the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), confer resistance against herbicide compositions provided in Table 1. Comparatively, none of the wild type cotton plants or cotton plants with control sequences show high levels of resistance against the herbicide compositions provided in Table 1.

[0190] Herbicide resistance tests of the compositions provided in Table 1 are completed in Brassica spp. plants (for example; canola and Arabidopsis} plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type Brassica spp. plants. Brassica spp. plants (for example; canola and Arabidopsis} plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) are produced using art known plant transformation methods and confirmed via molecular introgression studies. Next, Brassica spp. plants (for example; canola and Arabidopsis) plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), control nucleotide sequences and wild type Brassica spp. plants (for example; canola and Arabidopsis} plants are grown up and spayed with the herbicide compositions provided in Table 1 at varying concentrations. The Brassica spp. plants (for example; canola and Arabidopsis} plants are visually assessed once per week for three weeks after herbicide application for the percentage of Brassica spp. plants (forexample; canola and Arabidopsis) plants killed or showing severe herbicide-related injury (where 0% represents no activity and 100% represents death of all target Brassica spp. plants (for example; canola and Arabidopsis) plants). The results indicate that the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), confer resistance against herbicide compositions provided in Table 1. Comparatively, none of the wild type Brassica spp. plants or Brassica spp. plants with control sequences show high levels of resistance against the herbicide compositions provided in Table 1.

[0191] As observed in this example, com, soybean, cotton and Brassica spp. plants are transformed with polynucleotides encoding the 2,4-D resistance genes (for example, aad-12, aad- 1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) and these transgenic plants exhibit herbicide resistance to the compositions provided in Table 1.EVALUATION OF CONTROLLING UNDESIRABLE VEGETATION IN A FIELD OF HERBICIDE TOLERANT CROPS

[0192] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein. In certain applications the transgenes comprising 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) can be stacked with transgenes comprising glyphosate resistance genes.

[0193] The herbicide compositions provided in Table 1 provide weed control in soybean transformed with 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes). An experiment to compare the efficacy of herbicide compositions provided in Table 1 and / or glyphosate for control of weeds in fields of soybean plants transformed with the stacked glyphosate resistant gene and a 2,4-D resistant gene (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) is conducted at a number of field sites in different geological locations. The experimental design provides multiple replications per site with treatment plots in randomized complete blocks. Each plot has soybeanand weed plants that are grown according to art appreciated methods. The soybean and weed plants are targeted at differing growth development phases for an application of the different herbicides (glyphosate alone, herbicide compositions provided in Table 1 alone or glyphosate in combination with herbicide compositions provided in Table 1). The different herbicides are applied at varying concentrations. Weed species are visually assessed once per week for three weeks after herbicide application for the percentage plants killed or showing severe herbicide- related injury (where 0% represents no activity and 100% represents death of all target plants).

[0194] For nearly all targeted species and for each week of measurement, equal or greater levels of control are obtained with the higher application rate of the herbicide(s). Therefore, based on efficacy, the higher application rate of herbicides control >95% of weed plants kill or seriously injure after application; with two exceptions. For the plants of Amaranthus that are resistant to glyphosate (AMAPA gly-res), control is observed with the herbicide compositions provided in Table 1 alone or the combination of glyphosate with herbicide compositions provided in Table 1. There is no control of this weed species for the application of the glyphosate herbicide alone. Likewise, for the plant species of Sida spinosa and Sida alba that are resistant to glyphosate, control is observed with the herbicide compositions provided in Table 1 alone or the combination of glyphosate with herbicide compositions provided in Table 1. There is no control of this weed species for the application of the glyphosate herbicide alone. Results of these studies indicate that the herbicide compositions provided in Table lean be used to provide control of glyphosate resistant weed species in a field of soybean.

[0195] The herbicide compositions provided in Table 1 provide weed control in cotton transformed with 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes). An experiment to compare the efficacy of herbicide compositions provided in Table 1 and / or glyphosate for control of weeds in fields of cotton plants transformed with the stacked glyphosate resistant gene and a 2,4-D resistant gene (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes) is conducted at a number of field sites in different geological locations. The experimental design provides multiple replications per site with treatment plots in randomized complete blocks. Each plot has cotton and weed plants that are grown according to art appreciated methods. The cotton and weed plants are targeted at differing growth development phases for an application of the different herbicides (glyphosate alone, herbicide compositions provided in Table 1 alone or glyphosate in combination with herbicide compositions provided in Table 1). The different herbicides are applied at varyingconcentrations. Weed species are visually assessed once per week for three weeks after herbicide application for the percentage plants killed or showing severe herbicide-related injury (where 0% represents no activity and 100% represents death of all target plants).

[0196] For nearly all targeted species and for each week of measurement, equal or greater levels of control are obtained with the higher application rate of the herbicide(s). Therefore, based on efficacy, the higher application rate of herbicides control >95% of weed plants kill or seriously injure after application; with two exceptions. For the plants of Amaranthus that are resistant to glyphosate (AMAPA gly-res), control is observed with the herbicide compositions provided in Table 1 alone or the combination of glyphosate with herbicide compositions provided in Table 1. There is no control of this weed species for the application of the glyphosate herbicide alone. Likewise, for the plant species of Sida spinosa and Sida alba that are resistant to glyphosate, control is observed with the herbicide compositions provided in Table 1 alone or the combination of glyphosate with herbicide compositions provided in Table 1. There is no control of this weed species for the application of the glyphosate herbicide alone. Results of these studies indicate that the herbicide compositions provided in Table lean be used to provide control of glyphosate resistant weed species in a field of cotton.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN TOBACCO PLANTS TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0197] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0198] Herbicide resistance tests of the compound B8 as provided in Table 1 and 2,4-D at different application rates were sprayed on tobacco plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type tobacco plants. These experiments were completed to determine whether the compound B8 provided in Table 1 provides equivalent weed control to 2,4-D (formulated as either choline, ester or amine), and to determine whether compound B8 provided in Table 1 confers a greater selectivity margin between transgenic tobacco plants containing the 2,4-D resistance genes.

[0199] Transgenic tobacco seed were used in an initial experiment. The tobacco seed include wildtype tobacco of variety Kyi 60; AAD-1 expressing transgenic tobacco of variety Kyi 60 (containing construct pDAB721 as previously described in International Patent Publication No. W02005107437A2, herein incorporated by reference in its entirety); AAD- lxAAD-12 expressing transgenic tobacco of variety Kyl60 (AAD-1 containing construct pDAB721 as previously described in International Patent Publication No. W02005107437A2, herein incorporated by reference in its entirety and AAD-12 containing construct pDAB3278 or pDAS1580 as previously described in International Patent Publication No. W02007053482A2, herein incorporated by reference in its entirety); and the AAD-13 expressing transgenic tobacco of variety Kyi 60 (containing construct pDAB4114 as previously described in International Patent Publication No. W02008141154A2, herein incorporated by reference in its entirety).

[0200] The tobacco seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2 -leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designed included the following controls; an untreated control, adjuvant check control (at 1% COC). After application of the varying herbicide treatments the plants were monitored and observed for visual injury at 5, 11 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0201] The results as provided in Table 12 (Overall Injury (%) 5 DAA of herbicide treatment) and Table 13 (Overall Injury (%) 11 DAA of herbicide treatment) indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 5 DAA or 11 DAA. As shown in both tables, the wild type tobacco plants were injured by the treatments of differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 11 DAA as compared to 5 DAA.Table 12: Overall injury (%) observed 5 DAA of herbicide treatment for tobacco plantsMean Standard DeviationNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates.The offspring of the AADlxAAD12 cross were segregating. Two plants were identified as null and were omitted from analysis.Table 13: Overall injury (%) observed 11 DAA of herbicide treatment for tobacco plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standarddeviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”. The offspring of the AADlxAAD12 cross were segregating. Two plants were identified as null and were omitted from analysis.

[0202] As observed in this example, tobacco plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13, B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E10, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genes and these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN SOYBEAN PLANTS TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0203] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0204] Herbicide resistance tests of the composition compound B8 as provided in Table 1 and 2,4-D at different application rates were sprayed on soybean plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type soybean plants. These experiments were completed to determine whether the compound B8 as provided in Table 1 provides equivalent weed control to 2,4-D (formulated aseither choline, ester or amine), and to determine whether compound B8 as provided in Table 1 confers a greater selectivity margin between transgenic soybean plants containing the 2,4-D resistance genes.

[0205] Transgenic soybean seed were used in an initial experiment. The soybean seed include wildtype soybean of variety Maverick; AAD-12 expressing transgenic soybean of variety Maverick (containing construct pDAB8264 in soybean event pDAB8264.44.06.1 as previously described in International Patent Publication No. WO2012075426A1 herein incorporated by reference in its entirety); and the AAD-13 expressing transgenic soybean of variety Maverick (containing construct pDABl 15779 which contains the following gene elements; Arabidopsis Ubiquitin3 promoter: :AAD- 13 (vl):: Agrobacterium tumefaciens ORF23 3’UTR::Cassava Vein Mosaic Virus promoter: TAT: : Agrobacterium tumefaciens ORF1 3 ’UTR wherein versions of these genetic elements are as previously described in International Patent Publication No. W02008141154A2, WO2011049627A1, and WO2019211296 Aq, each of which are herein incorporated by reference in their entirety).

[0206] The soybean seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2 -leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designed included the following controls; an untreated control, adjuvant check control (at 1% COC). After application of the varying herbicide treatments the plants were monitored and observed for visual injury at 4, 10 and 12 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0207] The results as provided in Table 14 (Overall injury (%) 4 DAA of herbicide treatment), Table 15 (Overall injury (%) 10 DAA of herbicide treatment) and Table 16 (Overall injury (%) 12 DAA of herbicide treatment) indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 4 DAA, 10 DAA or 12 DAA.Moreover, the 2,4-D resistance genes, confer better resistance against the higher rates (2128 g ae / ha and 4256 g ae / ha) of compound B8 as provided in Table 1 as compared to the application of 2,4-D at similar rates. As shown in both tables, the wild type soybean plants were injured by the treatments of differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 12 DAA as compared to 4 DAA.Table 14: Overall injury (%) observed 4 DAA of herbicide treatment for soybean plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”. The offspring of the AAD13 seed lot were segregating. Eight plants were identified as null and were omitted from analysis.Table 15: Overall injury (%) observed 10 DAA of herbicide treatment for soybean plantsMean Standard DeviationNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”. The offspring of the AADlxAAD12 cross were segregating. Two plants were identified as null and were omitted from analysis.Table 16: Overall injury (%) observed 12 DAA of herbicide treatment for soybean plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”. The offspring of the AAD13 seed lot were segregating. Eight plants were identified as null and were omitted from analysis.

[0208] As observed in this example, soybean plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13, B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E10, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genes and these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN RICE PLANTS TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0209] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can betransformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0210] Herbicide resistance tests of the compound B8 provided in Table 1 and 2,4-D at different application rates were sprayed on rice plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type rice plants. These experiments were completed to determine whether the compound B8 as provided in Table 1 provides equivalent weed control to 2,4-D (formulated as either choline, ester or amine), and to determine whether compound B8 as provided in Table 1 confers a greater selectivity margin between transgenic rice plants containing the 2,4-D resistance genes.

[0211] Transgenic rice seed were used in an initial experiment. The rice seed include wildtype rice of variety Taipei 309; AAD-1 expressing transgenic rice of variety Taipei 309 (containing construct pDAB3403 as previously described in International Patent Publication No. W02005107437A2, herein incorporated by reference in its entirety).

[0212] The rice seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2 -leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designed included the following controls; an untreated control, adjuvant check control (at 1% COC).After application of the varying herbicide treatments the plants were monitored and observed for visual injury at 4 and 13 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0213] The results as provided in Table 17 (Overall injury (%) 4 DAA of herbicide treatment), Table 18 (Overall injury (%) 13 DAA of herbicide treatment) indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 4 DAA or 13 DAA. Moreover, the 2,4-D resistance genes, confer better resistance against the higher rates(2128 g ae / ha and 4256 g ae / ha) of compound B8 as provided in Table 1 as compared to the application of 2,4-D at similar rates. As shown in both tables, the wild type rice plants were injured by the treatments of differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 13 DAA as compared to 4 DAA.Table 17: Overall injury (%) observed 4 DAA of herbicide treatment for rice plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.* Seeds of the WT genotype selected for the trial germinated poorly; thus, a substitute WT population (WT alt) was included in the trial.Table 18: Overall injury (%) observed 13 DAA of herbicide treatment for rice plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.* Seeds of the WT genotype selected for the trial germinated poorly; thus, a substitute WT population (WT alt) was included in the trial.

[0214] As observed in this example, rice plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13, B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E10, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genesand these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN COTTON PLANTS TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0215] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0216] Herbicide resistance tests of the compound B8 as provided in Table 1 and 2,4-D at different application rates were sprayed on cotton plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type cotton plants. These experiments were completed to determine whether the compound B8 as provided in Table 1 provides equivalent weed control to 2,4-D (formulated as either choline, ester or amine), and to determine whether compound B8 as provided in Table 1 confers a greater selectivity margin between transgenic cotton plants containing the 2,4-D resistance genes.

[0217] Transgenic cotton seed were used in an initial experiment. The cotton seed include wildtype cotton of variety Coker 310; AAD-12 expressing transgenic cotton of variety Coker 310 (containing construct pDAB4468-Event 1910 as previously described in International Patent Publication No. WO2013112559A1, herein incorporated by reference in its entirety); and the AAD-12 expressing transgenic cotton of variety Coker 310 (containing construct pDAB4468- Event 1807 as previously described in International Patent Publication No. WO2013112525A2, herein incorporated by reference in its entirety).

[0218] The cotton seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2 -leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designedincluded the following controls; an untreated control, adjuvant check control (at 1% COC). After application of the varying herbicide treatments the plants were monitored and observed for visual injury at 5, 9 and 12 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0219] The results as provided in Table 19 (Overall injury (%) 5 DAA of herbicide treatment), Table 20 (Overall injury (%) 9 DAA of herbicide treatment) and Table 21 (Overall injury (%) 12 DAA of herbicide treatment) indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 5 DAA, 9 DAA or 12 DAA. Moreover, the 2,4-D resistance genes, confer better resistance against the higher rates (2128 g ae / ha and 4256 g ae / ha) of compound B8 as provided in Table 1 as compared to the application of 2,4-D at similar rates. As shown in both tables, the wild type cotton plants were injured by the treatments of differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 12 DAA as compared to 5 DAA.Table 19: Overall injury (%) observed 5 DAA of herbicide treatment for cotton plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 20: Overall injury (%) observed 9 DAA of herbicide treatment for cotton plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 21: Overall injury (%) observed 12 DAA of herbicide treatment for cotton plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.

[0220] As observed in this example, cotton plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13, B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E10, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genes and these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN CORN PLANTS TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0221] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0222] Herbicide resistance tests of the compound B8 as provided in Table 1 and 2,4-D at different application rates were sprayed on com plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type corn plants. These experiments were completed to determine whether the compound B8 as provided in Table 1 provides equivalent weed control to 2,4-D (formulated as either choline, ester or amine), and to determine whether compound B8 as provided in Table 1 confers a greater selectivity margin between transgenic corn plants containing the 2,4-D resistance genes.

[0223] Transgenic com seed were used in an initial experiment. The com seed include wildtype corn of variety Bl 04; AAD-1 expressing transgenic com of variety Bl 04 (containing construct pDAS1740 as previously described in International Patent Publication No.WO201 1022469A2, herein incorporated by reference in its entirety); and the AAD-12 expressing transgenic com of variety Bl 04 (containing construct pDAB4101 as previously described in International Patent Publication No. W02007053482A2, herein incorporated by reference in its entirety).

[0224] The corn seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2 -leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designed included the following controls; an untreated control, adjuvant check control (at 1% COC). After application of the varying herbicide treatments the plants were monitored andobserved for visual injury at 1, 4, 7, and 15 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0225] The results as provided in Table 22 (Overall injury (%) 1 DAA of herbicide treatment), Table 23 (Overall injury (%) 4 DAA of herbicide treatment), Table 24 (Overall injury (%) 7 DAA of herbicide treatment) and Table 25 (Overall injury (%) 15 DAA of herbicide treatment)indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 1 DAA, 4 DAA, 7 DAA or 15 DAA. Moreover, the 2,4-D resistance genes, confer better resistance against the higher rate (4256 g ae / ha) of compound B8 as provided in Table 1 as compared to the application of 2,4-D at similar rates. As shown in both tables, the wild type com plants were injured by the treatments of differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 15 DAA as compared to 1 DAA.Table 22: Overall injury (%) observed 1 DAA of herbicide treatment for corn plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 23: Overall injury (%) observed 4 DAA of herbicide treatment for corn plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 24: Overall injury (%) observed 7 DAA of herbicide treatment for corn plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 25: Overall injury (%) observed 15 DAA of herbicide treatment for corn plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.

[0226] As observed in this example, corn plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13, B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E10, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genes and these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN CANOLA PLANTS TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0227] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0228] Herbicide resistance tests of the compound B8 as provided in Table 1 and 2,4-D at different application rates were sprayed on canola plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type canola plants. These experiments were completed to determine whether the compound B8 asprovided in Table 1 provides equivalent weed control to 2,4-D (formulated as either choline, ester or amine), and to determine whether compound B8 as provided in Table 1 confers a greater selectivity margin between transgenic canola plants containing the 2,4-D resistance genes.

[0229] Transgenic canola seed were used in an initial experiment. The canola seed include wildtype canola of variety DH12075; AAD-1 expressing transgenic canola of variety DH12075 (containing construct pDAB721 as previously described in International Patent Publication No. W02007053482A2, herein incorporated by reference in its entirety); and the AAD-12 expressing transgenic canola of variety DH12075 (containing construct pDAB3759 as previously described in International Patent Publication No. W02007053482A2, herein incorporated by reference in its entirety).

[0230] The canola seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2 -leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designed included the following controls; an untreated control, adjuvant check control (at 1% COC).After application of the varying herbicide treatments the plants were monitored and observed for visual injury at 4, 8, and 14 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0231] The results as provided in Table 26 (Overall injury (%) 4 DAA of herbicide treatment), Table 27 (Overall injury (%) 8 DAA of herbicide treatment), and Table 28 (Overall injury (%) 14 DAA of herbicide treatment)indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 4 DAA, 8 DAA, or 14 DAA. Moreover, the 2,4-D resistance genes, confer better resistance against the higher rates (2128 or 4256 g ae / ha) of compound B8 as provided in Table 1 as compared to the application of 2,4-D at similar rates. As shown in both tables, the wild type Canola plants were injured by the treatments ofdiffering rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 14 DAA as compared to 4 DAA.Table 26: Overall injury (%) observed 4 DAA of herbicide treatment for canola plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 27: Overall injury (%) observed 8 DAA of herbicide treatment for canola plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 28: Overall injury (%) observed 14 DAA of herbicide treatment for canola plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standarddeviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.

[0232] As observed in this example, canola plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13, B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E10, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genes and these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN ARABIDOPSIS PLANTS TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0233] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0234] Herbicide resistance tests of the compound B8 as provided in Table 1 and 2,4-D at different application rates were sprayed on Arabidopsis plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type Arabidopsis plants. These experiments were completed to determine whether the compound B8 as provided in Table 1 provides equivalent weed control to 2,4-D (formulated as either choline, ester or amine), and to determine whether compound B8 as provided in Table 1 confers a greater selectivity margin between transgenic Arabidopsis plants containing the 2,4-D resistance genes.

[0235] Transgenic Arabidopsis seed were used in an initial experiment. The Arabidopsis seed include wildtype Arabidopsis of variety Columbia and the AAD-12 expressing transgenic Arabidopsis of variety Columbia (containing construct pDAB724 as previously described in International Patent Publication No. W02007053482A2, herein incorporated by reference in its entirety).

[0236] The Arabidopsis seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2-leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designed included the following controls; an untreated control, adjuvant check control (at 1% COC). After application of the varying herbicide treatments the plants were monitored and observed for visual injury at 1, 4, 7, and 14 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0237] The results as provided in Table 29 (Overall injury (%) 1 DAA of herbicide treatment), Table 30 (Overall injury (%) 4 DAA of herbicide treatment), Table 31 (Overall injury (%) 7 DAA of herbicide treatment), and Table 32 (Overall injury (%) 14 DAA of herbicide treatment)indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 1 DAA, 4 DAA, 7 DAA, or 14 DAA. Moreover, the 2,4-D resistance genes, confer better resistance against the higher rates (2128 or 4256 g ae / ha) of compound B8 as provided in Table 1 as compared to the application of 2,4-D at similar rates. As shown in both tables, the wild type Arabidopsis plants were injured by the treatments of differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 14 DAA as compared to 1 DAA.Table 29: Overall injury (%) observed 1 DAA of herbicide treatment for Arabidopsis plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 30: Overall injury (%) observed 4 DAA of herbicide treatment for Arabidopsis plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 31: Overall injury (%) observed 7 DAA of herbicide treatment for Arabidopsis plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, ateach assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 32: Overall injury (%) observed 14 DAA of herbicide treatment for Arabidopsis plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.

[0238] As observed in this example, Arabidopsis plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13,B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D3O, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E1O, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genes and these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.EVALUATION OF 2,4-D RESISTANCE GENE TOLERANCE IN TOBACCO PLANTS (SECOND EXPERIMENTS) TO THE COMPOSITIONS PROVIDED IN TABLE 1 AND 2,4-D

[0239] As previously discussed, the compounds disclosed herein exhibit varying pesticidal activity. For example, the pesticidal activity may include herbicidal activity. Transgenes that provide resistance to this herbicide activity are disclosed herein. Such transgenes can be transformed into crop plants to produce transgenic plants that are herbicide resistant to the compounds disclosed in Table 1, herein.

[0240] Herbicide resistance tests of the compound B8 as provided in Table 1 and 2,4-D at different application rates were sprayed on tobacco plants containing the 2,4-D resistance genes (for example, aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T and FT_Tv7 genes), and compared to control nucleotide sequence and wild type tobacco plants. These experiments were completed to determine whether the compound B8 provided in Table 1 provides equivalent weed control to 2,4-D (formulated as either choline, ester or amine), and to determine whether compound B8 provided in Table 1 confers a greater selectivity margin between transgenic tobacco plants containing the 2,4-D resistance genes.

[0241] Transgenic tobacco seed were used in a second experiment. The tobacco seed include wildtype tobacco of variety Kyi 60; AAD-1 expressing transgenic tobacco of variety Kyi 60 (containing construct pDAB721 as previously described in International Patent Publication No. W02005107437A2, herein incorporated by reference in its entirety); AAD- lxAAD-12 expressing transgenic tobacco of variety Kyl60 (AAD-1 containing construct pDAB721 as previously described in International Patent Publication No. W02005107437A2, herein incorporated by reference in its entirety and AAD-12 containing construct pDAB3278 or pDAS1580 as previously described in International Patent Publication No. W02007053482A2, herein incorporated by reference in its entirety); and the AAD-13 expressing transgenic tobacco of variety Kyi 60 (containing construct pDAB4114 as previously described in International Patent Publication No. W02008141154A2, herein incorporated by reference in its entirety).

[0242] The tobacco seed were sowed into either 9x14 or 12x14 plots and germinated. At the appropriate growth stage (2 -leaf or rosette) the herbicide treatment was applied at 14 treatments, consisting of 3 reps / treatment to result in testing 42 plants. Herbicide treatments can be applied to the plants at varying applications such as; 2,4-D choline (ENLIST ONE™) applied at 1064, 2128, and 4256 g ae / ha with 1% Crop Oil Concentrate (COC); 2,4-D EthylHexyl Ester (EHE) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; 2,4-D DMA salt (WEED AR™) applied at 1064, 2128, and 4256 g ae / ha with 1% COC; and compound B8 as provided in Table 1 applied at 1064, 2128, and 4256 g ae / ha with 1% COC. The types of herbicides actually used at specific rates for this experiment are described in the table below. In addition, the experimental designed included the following controls; an untreated control, adjuvant check control (at 1% COC). After application of the varying herbicide treatments the plants were monitored and observed for visual injury at 1, 5 and 8 days after application (DAA). The scale for visible injury was scored as 0 for no visible injury to 100 for plant death.

[0243] The results as provided in Table 33 (Overall Injury (%) 1 DAA of herbicide treatment) Table 34 (Overall Injury (%) 5 DAA of herbicide treatment) and Table 35 (Overall Injury (%) 8 DAA of herbicide treatment) indicate that the 2,4-D resistance genes, confer resistance against differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D comparatively. The data indicated that each of the 2,4-D resistance genes provided protection as no injury was observed for treated plants at 5 DAA or 11 DAA. As shown in both tables, the wild type tobacco plants were injured by the treatments of differing rates of compound B8 as provided in Table 1 and to differing rates of 2,4-D, and the reported injury for these wild type plants was greater at 8 DAA as compared to 1 DAA.Table 33: Overall injury (%) observed 1 DAA of herbicide treatment for tobacco plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates.Table 34: Overall injury (%) observed 5 DAA of herbicide treatment for tobacco plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standarddeviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.Table 35: Overall injury (%) observed 8 DAA of herbicide treatment for tobacco plantsNotes: Visual assessments of crop injury (% overall injury) were taken at multiple time points [days after application (DAA)] after herbicide application. Treatment means and the standard deviations of those means are shown for each genotype, including wild type (WT) controls, at each assessment timepoint. All treatments were applied post-emergently with 1% crop oil concentrate (COC). Most treatments contained 3 replicates. The term “NT” means “no test”.

[0244] As observed in this example, tobacco plants are transformed with polynucleotides encoding the 2,4-D resistance genes and these transgenic plants exhibit herbicide resistance to over-the-top applications of compound B8 as provided in Table 1 applied at differing rates. Those with skill in the art would appreciate that any other compound as listed in Table 1 (Al, A2, A3, A4, A5, A6, A7, A8, A9, A10, Al l, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37,A38, A39, A40, A41, Bl, B2, B3, B4, B5, B6, B7, B9, BIO, Bl l, B12, B13, B14, B15, B16, B17, B18, B19, Cl, DI, D2, D3, D4, D5, D6, D7, D8, D9, DIO, Dl l, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D3O, D31, D32, D33, D34, El, E2, E3, E4, E5, E6, E7, E8, E9, E1O, El l, E12, E13, E14, E15, E16, E17, E18, or E19) could be applied over plants that express polynucleotides encoding the 2,4-D resistance genes and these transgenic plants would exhibit herbicide resistance to over-the-top applications of the herbicide in similar assays.

[0245] While this disclosure has been described using exemplary details, the present disclosure may be further modified within the spirit and scope of this disclosure. This application is therefore intended to cover any variations, uses, or adaptations of the disclosure using its general principles. Further, this application is intended to cover such departures from the present disclosure as come within known or customary practice in the art to which this disclosure pertains.

[0246] The benefits, advantages, solutions to problems, and any elements that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as critical, required, or essential features or elements. The scope is accordingly to be limited by nothing other than the appended claims, in which reference to an element in the singular is not intended to mean “one and only one” unless explicitly so stated, but rather “one or more.”

[0247] In the detailed description herein, references to “one aspect,” “an aspect,” “an example aspect,” “detail” etc., indicate that the aspect described may include a particular feature, structure, or characteristic, but every aspect may not necessarily include the particular feature, structure, or characteristic. Moreover, such phrases are not necessarily referring to the same aspect. Further, when a particular feature, structure, or characteristic is described in connection with an aspect, it is submitted that it is within the knowledge of one skilled in the art with the benefit of the present disclosure to affect such feature, structure, or characteristic in connection with other aspects whether or not explicitly described. After reading the description, it will be apparent to one skilled in the relevant art(s) how to implement the disclosure in alternative aspects.

[0248] Furthermore, no element, component, or method step in the present disclosure is intended to be dedicated to the public regardless of whether the element, component, or method step is explicitly recited in the claims.

Claims

CLAIMS1. A method for controlling weeds in transgenic crop plants which contain a 2,4-D resistance gene by treating the broad-leaved weeds, grass weeds and transgenic crop plants with a herbicide composition listed in Table 1.

2. The method of controlling weeds in transgenic crop plants according to claim 1, wherein at least a second herbicide composition is applied to the transgenic crop plants.

3. The method of controlling weeds in transgenic crop plants according to claim 2, wherein the second herbicide composition is selected from the group of a synthetic auxin type herbicide, an ALS inhibitor herbicide, a triazolopyrimidine sulfonamide herbicide, an imidazolinone herbicide, a pyrimidinyl oxybenzoate herbicide, a sulfonylaminocarbonyl triazolinone herbicide, a sulfonylurea herbicide, a benzoic acid herbicide, an aryl picolinate herbicide, a pyridine carboxylate herbicide, a quinoline carboxylic acid herbicide, an auxin transport inhibitor herbicide, a PPO inhibitor herbicide, a PDS inhibitor herbicide, a glyphosate herbicide, a glufosinate herbicide, a photosystem II herbicide, an HPPD inhibitor herbicide, an ACCase inhibitor herbicide, or any combination thereof.

4. The method of controlling weeds in transgenic crop plants according to claim 3, wherein the synthetic auxin type herbicide is selected from the group 2,4-D, 2,4-DB, MCPA, mecoprop, dichlorprop, 2,4, 5-T, triclopyr, chloramben, dicamba, 2,3,6-TBA, tricamba, clopyralid, picloram, quinmerac, quinclorac, benazolin, fenac, IAA, NAA, orthonil and fluroxypyr.

5. The method of controlling weeds in transgenic crop plants according to claim 2, wherein the second herbicide composition is selected from the group of a synthetic auxin type, acetolactate synthase (ALS) or acetohydroxy acid synthase (AHAS) inhibitors, (e.g., imidazolinones, sulfonylureas, pyrimidinylthiobenzoates, triazolopyrimidines, and sulfonylaminocarbonyltriazolinones), photosystem II inhibitors (e.g., phenylcarbamates, pyridazinones, triazines, triazinones, uracils, amides, ureas, benzothiadiazinones, nitriles, phenylpyridazines), acetyl CoA carboxylase (ACCase) inhibitors, (e.g., aryloxyphenoxypropionates, cyclohexanediones, phenylpyrazolines), synthetic auxins (e.g., benzoic acids, phenoxycarboxylic acids, pyridine carboxylic acids, quinoline carboxylic acids), auxin transport inhibitors (e.g., phthalamates, semicarbazones), photosystem I inhibitors (e.g., bipyridyliums), 5 -enolpyruvylshikimate-3 -phosphate (EPSP) synthase inhibitors (e.g.,glyphosate), glutamine synthetase inhibitors (e.g., glufosinate, bialafos), microtubule assembly inhibitors (e.g., benzamides, benzoic acids, dinitroanilines, phosphoramidates, pyridines), mitosis inhibitors (e.g., carbamates), very long chain fatty acid (VLCFA) inhibitors (e.g., acetamides, chloroacetamides, oxyacetamides, tetrazolinones), fatty acid and lipid synthesis inhibitors (e.g., phosphorodithioates, thiocarbamates, benzofuranes, chlorocarbonic acids), protoporphyrinogen oxidase (PPO) inhibitors (e.g., diphenylethers, N-phenylphthalimides, oxadiazoles, oxazolidinediones, phenylpyrazoles, pyrimidindiones, thiadiazoles, triazolinones), carotenoid biosynthesis inhibitors (e.g., clomazone, amitrole, aclonifen), phytoene desaturase (PDS) inhibitors (e.g., amides, anilidex, furanones, phenoxybutan-amides, pyridiazinones, pyridines), 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors (e.g., calli stem ones, isoxazoles, pyrazoles, triketones), cellulose biosynthesis inhibitors (e.g., nitriles, benzamides, quinclorac, triazolocarboxamides), herbicides with multiple modes-of-action such as quinclorac, and unclassified herbicides such as arylaminopropionic acids, difenzoquat, endothall, and organoarsenicals.

6. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the herbicide composition listed in Table 1 and the second herbicide composition are applied sequentially or concurrently.

7. The method of controlling weeds in transgenic crop plants according to claim 6, wherein the herbicide composition listed in Table 1 and the second herbicide composition are applied at the early post-emergence stage, at the late post-emergence stage, at the pre-harvest stage, or at the post-harvest stage.

8. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the herbicide composition listed in Table 1 and the second herbicide composition are applied before or after the planting of a seed.

9. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the seed is planted in the soil within at least 21 days before or after the herbicide is applied.

10. The method of claim 1, wherein the herbicide composition listed in Table 1 is applied at a time selected from the group consisting of between about the VI to V2 and V3 to V4 stages, before flowering, at flowering, after flowering, and at seed formation.

11. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the transgenic crop plants comprise one of Brassica spp., cotton, soybeans, alfalfa, rice, wheat, and corn.

12. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the 2,4-D resistance gene is selected from the group of an aad-12, aad-1, aad-2, aad-13, tfdA, 24DT22, 24DT21, 24DT11, IAA2, modified RdpA, FT_T or an FT_Tv7 genes or an engineered variant thereof.

13. The method of controlling weeds in transgenic crop plants according to claim 11, wherein the 2,4-D resistance gene is an aad-12 gene.

14. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the 2,4-D resistance gene shares at least 90% sequence identity to a sequence selected from the group consisting of SEQ ID NO: 1 through SEQ ID NO:35 or an engineered variant thereof.

15. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the 2,4-D resistance gene shares at least 90% sequence identity to SEQ ID NO: 1.

16. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the transgenic crop plants comprise a second herbicide resistance gene.

17. The method of controlling weeds in transgenic crop plants according to claim 16, wherein the second herbicide resistance gene is selected from the group consisting of a glyphosate resistance gene, a glufosinate resistance gene, a bromoxynil resistance gene, a ppo resistance gene, an ALS resistance gene, a HPPD resistance gene or any combination thereof.

18. The method of controlling weeds in transgenic crop plants according to claim 16, wherein the second herbicide resistance gene encodes a polypeptide selected from the group consisting of DGT28, glyphosate resistant 5 -enolpyruvylshikimate-3 -phosphate synthase (EPSPS), glyphosate oxidoreductase (GOX), glyphosate-N-acetyl transferase (GAT) and glyphosate decarboxylase.

19. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the weeds are selected from dicot or monocot weeds.

20. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the herbicide treatment controls the growth of a herbicide resistant weed selected from the group consisting of: Alopecurus myosuroides, Avena fatua, Avena sterilis, Avena sterilis ludoviciana, Brachiaria plantaginea, Bromus diandrus, Bromus rigidus, Cynosurus echinatus, Digitaria ciliaris, Digitaria ischaemum, Digitaria sanguinalis, Echinochloa colona, Echinochloa crus-galli, Echinochloa oryzicola, Echinochloa phyllopogon, Eleusine indica, Eriochloa punctata, Hordeum glaucum, Hordeum leporinum, Ischaemum rugosum, Leptochloa chinensis, Lolium multiflorum, Lolium perenne, Lolium persicum, Lolium rigidum, Phalaris minor, Phalaris paradoxa, Rottboellia exalta, Setaria faberi, Setaria viridis, Setaria viridis var. robusta-alba schreiber, Setaria viridis var. robusta-purpurea, Snowdenia polystachea, Sorghum halepense, Sorghum Sudanese, Alisma plantago-aquatica, Amaranthus blitoides, Amaranthus hybridus, Amaranthus lividus, Amaranthus palmeri, Amaranthus powellii, Amaranthus quitensis, Amaranthus retroflexus, Amaranthus rudis, Amaranthus tuberculatus, Ambrosia artemisiifolia, Ambrosia trifida, Ammania auriculata, Ammania coccinea, Anthemis cotula, Apera spica-venti, Bacopa rotundifolia, Bidens pilosa, Bidens subaltemans, Brassica toumefortii, Bromus tectorum, Camelina microcarpa, Chenopodium album, Chrysanthemum coronarium, Conyza bonariensis, Conyza canadensis, Cuscuta campestris, Cyperus difformis, Damasonium minus, Descurainia sophia, Diplotaxis tenuifolia, Echium plantagineum, Elatine triandra var. pedicellata, Euphorbia heterophylla, Fallopia convolvulus, Fimbristylis miliacea, Galeopsis tetrahit, Galium spurium, Helianthus annuus, Iva xanthifolia, Ixophorus unisetus, Kochia scoparia, Lactuca serriola, Limnocharis flava, Limnophila erecta, Limnophila sessiliflora, Lindemia dubia, Lindemia dubia var. major, Lindemia micrantha, Lindemia procumbens, Mesembryanthemum crystallinum , Monochoria korsakowii, Monochoria vaginalis, Neslia paniculata, Papaver rhoeas, Parthenium hysterophorus, Pentzia suffruticosa, Phalaris minor, Raphanus raphanistrum, Raphanus sativus, Rapistrum rugosum, Rotala indica var. uliginosa, Sagittaria guyanensis, Sagittaria montevidensis, Sagittaria pygmaea, S al sol a ib erica, Scirpus juncoides var. ohwianus, Scirpus mucronatus, Setaria lutescens, Sida spinosa, Sinapis arvensis, Sisymbrium orientale, Sisymbrium thellungii, Solarium ptycanthum, Sonchus asper, Sonchus oleraceus, Sorghum bicolor, Stellaria media, Thlaspi arvense, Xanthium strumarium, Arctotheca calendula, Conyza sumatrensis, Crassocephalum crepidiodes, Cuphea carthagenenis, Epilobium adenocaulon, Erigeron philadelphicus, Landoltia punctata, Lepidium virginicum, Monochoria korsakowii, Poa annua, Solanum americanum, Solanum nigrum, Vulpia bromoides, Youngia japonica, Hydrilla verticillata, Plantago lanceolata, Carduus nutans, Carduus pycnocephalus, Centaurea solstitialis,Cirsium arvense, Commelina diffusa, Convolvulus arvensis, Daucus carota, Digitaria ischaemum, Echinochloa crus-pavonis, Fimbristylis miliacea, Galeopsis tetrahit, Galium spurium, Limnophila erecta, Matricaria perforate, Papaver rhoeas, Ranunculus acris, Soliva sessilis, Sphenoclea zeylanica, Stellaria media, Nassella trichotoma, Stipa neesiana, Agrostis stolonifera, Polygonum aviculare, Alopecurus japonicus, Beckmannia syzigachne, Bromus tectorum, Chloris inflate, Echinochloa erecta, Portulaca oleracea, and Senecio vulgaris.

21. The method of controlling weeds in transgenic crop plants according to claim 3, further comprising: a) identifying a herbicide resistant broad-leaved weed or grass weed that is tolerant to at least the second herbicide composition; and b) applying an amount of herbicide composition listed in Table 1 effective to control the herbicide resistant broad-leaved weed or grass weed.

22. The method of controlling weeds in transgenic crop plants according to claim 1, wherein at least a second pesticide composition comprising a fungicide, nematicide, bactericide, and / or an insecticide is applied to the transgenic crop plants.

23. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the herbicide composition listed in Table 1 is applied at a rate of between about 200 grams to about 2,000 grams of acid equivalent per hectare (g ae / ha).

24. The method of controlling weeds in transgenic crop plants according to claim 1, wherein the herbicide composition listed in Table 1 is applied at a is between about 800 g ae / ha to about 1,200 g ae / ha.

25. The method of controlling weeds in transgenic crop plants according to claim 23, wherein the herbicide composition listed in Table 1 is applied to a field of herbicide resistant weeds.

26. The method of controlling weeds in transgenic crop plants according to claim 25, wherein the herbicide resistant weeds are toleratn to the herbicides selected from the group of a synthetic auxin type, acetolactate synthase (ALS) or acetohydroxy acid synthase (AHAS) inhibitors, (e.g., imidazolinones, sulfonylureas, pyrimidinylthiobenzoates, triazolopyrimidines, and sulfonylaminocarbonyltriazolinones), photosystem II inhibitors (e.g., phenylcarbamates,pyridazinones, triazines, triazinones, uracils, amides, ureas, benzothiadiazinones, nitriles, phenylpyridazines), acetyl CoA carboxylase (ACCase) inhibitors, (e.g., aryloxyphenoxypropionates, cyclohexanediones, phenylpyrazolines), synthetic auxins (e.g., benzoic acids, phenoxycarboxylic acids, pyridine carboxylic acids, quinoline carboxylic acids), auxin transport inhibitors (e.g., phthalamates, semicarbazones), photosystem I inhibitors (e.g., bipyridyliums), 5 -enolpyruvylshikimate-3 -phosphate (EPSP) synthase inhibitors (e.g., glyphosate), glutamine synthetase inhibitors (e.g., glufosinate, bialafos), microtubule assembly inhibitors (e.g., benzamides, benzoic acids, dinitroanilines, phosphoramidates, pyridines), mitosis inhibitors (e.g., carbamates), very long chain fatty acid (VLCFA) inhibitors (e.g., acetamides, chloroacetamides, oxyacetamides, tetrazolinones), fatty acid and lipid synthesis inhibitors (e.g., phosphorodithioates, thiocarbamates, benzofuranes, chlorocarbonic acids), protoporphyrinogen oxidase (PPO) inhibitors (e.g., diphenylethers, N-phenylphthalimides, oxadiazoles, oxazolidinediones, phenylpyrazoles, pyrimidindiones, thiadiazoles, triazolinones), carotenoid biosynthesis inhibitors (e.g., clomazone, amitrole, aclonifen), phytoene desaturase (PDS) inhibitors (e.g., amides, anilidex, furanones, phenoxybutan-amides, pyridiazinones, pyridines), 4-hydroxyphenyl-pyruvate-dioxygenase (HPPD) inhibitors (e.g., calli stem ones, isoxazoles, pyrazoles, triketones), cellulose biosynthesis inhibitors (e.g., nitriles, benzamides, quinclorac, triazolocarboxamides), herbicides with multiple modes-of-action such as quinclorac, and unclassified herbicides such as arylaminopropionic acids, difenzoquat, endothall, and organoarsenicals.

27. A cropping system for minimizing the development of a herbicide resistant broad-leaved weed or grass weed in a crop-growing environment comprising: a) planting in a field a crop plant having tolerance to a first herbicide and a herbicide composition listed in Table 1; b) applying at least a first herbicide treatment comprising the first herbicide and / or herbicide composition listed in Table 1 to the crop growing environment to control weeds; c) identifying a location in the field infested with weeds resistant to the first herbicide; and d) applying an amount of the herbicide composition listed in Table leffective to control the weeds resistant to the first herbicide.

28. A method for minimizing the development of a herbicide resistant weed comprising: rotating a first cropping system in a first growing season with a second cropping system in asubsequent growing season, wherein the first and second cropping systems comprise a cropping system according to claim 27.

29. The method of claim 28, wherein the crop plant in the first cropping system possesses at least one different herbicide tolerance relative to the crop plant in the second cropping system.

30. The method of claim 29, wherein the crop plant in the first cropping system and crop plant in the second cropping system are the same species.

31. The method of claim 28, wherein the crop plant in the first cropping system and crop plant in the second cropping system are different species.

32. A method for controlling a glyphosate tolerant weed in a field comprising: a) planting a transgenic seed in a field comprising a glyphosate tolerant weed or a seed thereof, wherein the seed comprises a transgene conferring glyphosate tolerance and a transgene encoding tolerance to a herbicide composition listed in Table 1; b) growing the seed into a plant; and c) treating the field with an amount of a herbicide composition listed in Table 1 and glyphosate effective to control weed growth of the glyphosate tolerant weed.

33. A method for controlling weed growth in a field comprising: a) planting a transgenic seed in a field comprising a weed or a seed thereof, wherein the transgenic seed comprises a transgene conferring resistance to a herbicide composition listed in Table 1 and at least a second transgene conferring resistance to a second herbicide compound; b) treating the field with a herbicidally effective amount of herbicide composition listed in Table 1, at least a second herbicide compound, or a mixture thereof; and c) growing the transgenic seed into a plant.

34. A method of assaying an herbicide tolerance characteristic in a plant comprising (a) treating at least one plant or seed with a herbicidally effective amount of a herbicide composition listed in Table 1; and (b) evaluating one or more properties of the at least one plant treated with the herbicidally effective amount of a herbicide composition listed in Table 1.

35. A method of controlling undesirable vegetation which comprises contacting the vegetation or the locus thereof with, or applying to the soil to prevent the emergence of vegetation, a herbicidally effective amount of a herbicide composition listed in Table 1.

36. The method of controlling undesirable vegetation according to claim 35, wherein the compound is applied at a rate of between about 200 grams to about 2,000 grams of acid equivalent per hectare (g ae / ha).

37. The method of controlling undesirable vegetation according to claim 36, wherein the rate is between about 800 g ae / ha to about 1,200 g ae / ha.

38. A method of controlling undesirable vegetation in a crop that has been made tolerant or resistant to 2,4-dichlorophenoxyacetic acid, which comprises contacting the vegetation or the locus thereof with a herbicidally effective amount of a compound or applying to the soil to prevent the emergence of vegetation, a herbicidally effective amount of a compound.

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