Liquid composition for protecting phospholipid membrane

A magnesium-based liquid composition with buffers and additives stabilizes phospholipid membranes against damage, ensuring stability and efficacy in pharmaceutical and therapeutic applications.

WO2025204688A1PCT designated stage Publication Date: 2025-10-02DAICEL CORP
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Patent Information

Application Number
PCT/JP2025/008174
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-03-26
Filing Date
2025-03-06
Publication Date
2025-10-02

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Abstract

The purpose of the present disclosure is to provide a protective agent excellent in a protective effect of a phospholipid membrane. This liquid composition for protecting a phospholipid membrane comprises (A) a magnesium salt, (B) an acetate buffer solution, a citrate buffer solution, a carbonate buffer solution, and / or a succinate buffer solution, and preferably further contains at least any of (C) a polyhydric alcohol, (D) a saccharide and / or a sugar alcohol, (E) polyethylene glycol, and (F) an amino acid. The liquid composition for protecting the phospholipid membrane is excellent in the protective effect of the phospholipid membrane.
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Citation Information

Patent Citations

  • Clinical formulation

    JP2018523682A

  • Pharmaceutical composition in lyophilized form

    JP2021528450A

  • Pharmaceutical formulations of chelating agents as a metal removal treatment system

    US20140271825A1

  • Magnesium-liposome complexes

    US20160220604A1