Device for non-invasively checking a person's blood glucose concentration

Abstract

The invention relates to medicine and technology, and more particularly to non-invasively detecting a change in a person's blood glucose concentration, and can be used in the creation of devices for this purpose, as well as in the creation of socially-oriented systems for the early diagnosis of diabetes and associated diseases, in the form of a pendant. The aim of the invention is to improve the operational efficiency of a device for non-invasively checking a person's blood glucose concentration by reducing the set-up and configuration time required. This aim is achieved in that the claimed device for non-invasively checking a person's blood glucose concentration comprises a housing, a control and display module disposed in the housing, a sensor, a radiation emitter and a receiver for receiving radiation reflected from a person's tissues, the emitter and the receiver being disposed in the sensor and the working surface of the sensor having a rim disposed thereon which surrounds the light receiver and separates it from the light emitter. The technical results of the invention include a simplified design, the possibility of visually checking the correct positioning of the sensor on a pulse point, and the possibility of keeping the device in a working state using one hand while simultaneously operating a touchscreen using a digit of the same hand.

Description

[0001] DEVICE FOR NON-INVASIVE MONITORING OF GLUCOSE CONTENT IN HUMAN BLOOD.

[0002] DESCRIPTION.

[0003] The invention relates to medicine and technology, specifically to the non-invasive determination of changes in glucose levels in human blood, and can find application in the creation of devices for this purpose, as well as in the creation of socially oriented systems for the early diagnosis of diabetes and related diseases in the form of a keychain.

[0004] Prior art.

[0005] For diabetics, constant blood glucose monitoring is vital. New developments based on non-invasive methods that measure health parameters without drawing blood are currently being used for this purpose.

[0006] Many methods and devices have been developed for non-invasive determination of changes in human blood glucose levels. Thus, glucose is monitored through electrical transfer functions (RU Patent 2342071, published 2007), through laser beam irradiation of areas of maximum blood vessel concentration on the mucous membrane (RU Patent 2295915, published 2005), through measuring systolic and diastolic blood pressure sequentially on the left and right hands (RU Patent 2368303, published 2007), and even through a person's voice (RU Patent 2506893, published 02 / 20 / 2014). A good non-invasive glucometer is a device in the form of a wristwatch - a "smart watch" that determines glucose, as well as pulse, pressure and other parameters (see source / 3 / ).

[0007] The best modern non-invasive glucometer is a wristwatch-style device—a "smartwatch"—that measures glucose, heart rate, blood pressure, and other parameters (see source / 1 / ). The device contains a sensor for monitoring the pulse wave signal, determining blood sugar levels, and other blood parameters. It also allows for manual location of the radial artery and targeting of the sensor. Changes in pulse wave parameters are used to determine changes in a person's blood sugar and other parameters.

[0008] Such a device contains a housing, a control and display module located in the housing, a sensor, a radiation emitter and a receiver of radiation reflected from human tissue, located in the sensor.

[0009] The control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, designed with the possibility of inputting and outputting information by touching it with a human finger.

[0010] The case with the control and display module resembles a wristwatch in appearance.

[0011] For simplicity, the control and display module may be referred to as the control module.

[0012] The sensor contains a light emitter and a light receiver and is positioned above the radial artery on a person's arm and is connected to a control and display module via a communication channel.

[0013] For simplicity, a device for non-invasive monitoring of glucose levels in human blood can be simply called a device.

[0014] The sensor in a device for noninvasively monitoring human blood glucose levels may be simply referred to as a sensor. For simplicity, the light emitter may be simply referred to as an emitter. For simplicity, the light receiver may be simply referred to as a receiver.

[0015] An analog of the invention is a wrist-worn device for non-invasive monitoring of human blood glucose levels using infrared light with a teletransmission function for determining blood glucose levels. (CN 110236487 A, published 2019.09.17).

[0016] The publication discloses the design of the device. The sensor included in the device includes an emitter and a receiver for radiation reflected from human tissue. The analog features, which match the features of the invention, include a housing, a control and display module located within the housing, a sensor, a radiation emitter, and a receiver for radiation reflected from human tissue, all located within the sensor.

[0017] The control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, designed with the possibility of inputting and outputting information by touching it with a human finger.

[0018] A disadvantage of the analog is the need to wear the device constantly, which many people find uncomfortable. Furthermore, there's no visual verification of proper placement of the sensor at the pulse measurement site. The sensor is located at the end of one of the strap sections. When placing the sensor at the pulse measurement site, the wearer can't see the sensor or the area on the arm where it needs to be pressed. The watch case and the wearer's arm obscure the sensor, resulting in poor accuracy in applying the sensor to the pulse measurement site.

[0019] The prototype of the invention is a device for non-invasive monitoring of glucose content in human blood, comprising a housing, a control and display module located in the housing, a sensor, a radiation emitter and a receiver of radiation reflected from human tissues, located in the sensor, and light is used as radiation, and on the working surface of the sensor there is a rim surrounding the light receiver and separating it from the light emitter, and the control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, and the touch screen is made with the possibility of inputting and outputting information by touching it with a human finger, wherein the radiation emitter and the receiver of radiation reflected from human tissues are connected to the control and display module located in the housing via a wired communication line.

[0020] These features of the prototype coincide with those of the invention. Furthermore, the prototype's sidewall is rectangular in cross-section.

[0021] The prototype design is described in the article: New Developments in Wrist Devices for Non-Invasive Monitoring of Human Blood Glucose Content, as well as for Monitoring Other Human Health Parameters. Terms and Definitions. Tikhonenko D. O., Tikhonenko O. O., Lobko V. P., published in the collection: Higher School: Scientific Research. Proceedings of the Interuniversity International Congress (Moscow, October 13, 2023). Volume 1. - Moscow: Infinity Publishing House, 2023. - 170 p.

[0022] Also information about the prototype is posted in the source / 3 / .

[0023] The prototype works in conjunction with a smartphone. It connects to the smartphone via WiFi when taking measurements. All data collected during measurements is transmitted to the smartphone.

[0024] A disadvantage of the prototype is the low operational efficiency for non-invasive monitoring of glucose levels in human blood due to the long time required for preparation for operation and setup.

[0025] Another drawback of the prototype is the need to constantly wear the device on the wrist (it is secured with a strap), which many people find uncomfortable. Furthermore, there is no visual verification of the sensor's correct placement at the pulse measurement site. The sensor is located at the end of one of the strap sections on the inner side. When placing the sensor at the pulse measurement site, the user cannot see the sensor or the area on the wrist where it is placed. The sensor is obscured by the device body and the user's arm. This results in low accuracy of sensor placement at the pulse measurement site, as well as high power consumption for noninvasive blood glucose monitoring due to the prototype's long preparation time.

[0026] The essence of the invention.

[0027] The purpose of the invention is to improve the operational efficiency of a device for noninvasive blood glucose monitoring by reducing setup and configuration time. Operational efficiency refers to speed of operation and the ability to quickly bring the device into operation, specifically without frequent preliminary setup.

[0028] The objective is achieved in that a device for non-invasive monitoring of glucose levels in human blood comprises a housing, a control and display module located in the housing, a sensor, a radiation emitter and a receiver of radiation reflected from human tissues, located in the sensor, and light is used as radiation, and on the working surface of the sensor there is a rim surrounding the light receiver and separating it from the light emitter, and the control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, and the touch screen is designed with the possibility of inputting and outputting information by touching it with a human finger, wherein the radiation emitter and the receiver of radiation reflected from human tissues are connected to the control and display module located in the housing by means of a wired communication line, and differs from the prototype in that the housing of the device,is made elongated in the longitudinal direction, with a length from 60 mm to 100 mm, a width from 40 mm to 70 mm, a thickness from 10 mm to 20 mm, in addition, the length of the touch screen is from 40 mm to 70 mm, the width of the touch screen is from 40 mm to 70 mm, and the sensor is made with a diameter from 10 mm to 20 mm; and the sensor is located on the rear surface of the device housing at the lower end side of the device housing, wherein the light emitter and the light receiver are located on the working side of the sensor and are directed outward in the direction of an axis perpendicular to the longitudinal axis of the device and perpendicular to the transverse axis of the device; and when preparing for operation and during operation, the device is configured to press the sensor with the emitter and receiver to the place of palpation of the pulse on the radial artery of the arm; and, in addition, the device is configured to visually control the pressing of the sensor with the emitter and receiver to the place of palpation of the pulse on the radial artery of the arm; wherein,The light emitter and the light receiver are designed in such a way that when the sensor is pressed against the hand in the working position, the light emitter is configured to emit light into the hand onto the radial artery, and the light receiver is configured to receive reflected light from the radial artery of the human hand; and, in addition, the device for non-invasive monitoring of glucose content in human blood is configured to be held in the working state by one hand of the person and to be able to input and output information by touching the touch screen with a finger of the same hand.

[0029] In a particular embodiment of the invention, the device can be made in such a way that when the sensor is in the working position, pressed to the hand, the light emitter is configured to emit light into the hand onto the radial artery at the base of the thumb of the human hand, or onto the radial artery of the wrist, or onto the radial artery of the forearm, and the receiver is configured to receive reflected light from the hand, namely, from the radial artery at the base of the thumb of the human hand, or from the radial artery of the wrist, or from the radial artery of the forearm.

[0030] In a particular embodiment of the invention, the device can be designed in such a way that the ridge of the side is made with projections and depressions alternating along its length, or riffles are made on the ridge of the side.

[0031] In a particular embodiment of the invention, the device can be designed in such a way that the ridge of the side is made with projections and depressions alternating along its length and grooves are made on the ridge of the side.

[0032] Furthermore, in a particular embodiment of the invention, the device can be designed so that, when preparing it for use, the pulse palpation site on the radial artery of the hand is moistened with water. This is accomplished by moistening the pulse palpation site on the radial artery of the hand during testing.

[0033] Also, in a specific embodiment of the invention, the device can be designed so that when preparing it for use, the pulse palpation site on the radial artery of the hand is wiped dry. This is done when testing the device, the pulse palpation site on the radial artery of the hand is wiped dry.

[0034] For simplicity of presentation of the material, we will call the device for non-invasive monitoring of glucose levels in human blood the device.

[0035] For simplicity of presentation of the material, we will call the emitter of radiation and the receiver of radiation reflected from human tissue the emitter and receiver.

[0036] The device is designed to manually determine the location of the radial artery based on the pulse palpation site and to direct the emitter and receiver to it.

[0037] Technical results of the invention:

[0038] 1. There's no need to wear a noninvasive blood glucose monitoring device on your arm. For many people, wearing a device on your arm is inconvenient. This drawback is eliminated in the proposed device. The device can be worn, for example, in a pocket or on a necklace.

[0039] 2. Compared to the prototype, the design of the device has been simplified by reducing the weight of the device due to the absence of a strap and making it in the form of a key fob (keychain).

[0040] 3. Visual verification of the correct placement of the noninvasive blood glucose monitoring device sensor at the pulse site is provided. When placing the sensor at the pulse site, the user can see the sensor and the location on the arm where it should be pressed. This improves the accuracy of sensor placement at the pulse site, minimizing the risk of misplacing the sensor.

[0041] 4. It is possible to hold the device for non-invasive monitoring of human blood glucose levels in a working state when preparing it for operation and during operation using one hand and simultaneously operate the touch screen using a finger of the same hand.

[0042] 5. Reduction of energy consumption for non-invasive monitoring of human blood glucose levels due to precise orientation of the emitter and receiver to the artery and reduction of the preparation time of the device for non-invasive monitoring of human blood glucose levels for operation.

[0043] A specific technical result of creating a ridge on the edge with alternating protrusions and depressions or with ribs is an increase in the contact area of ​​the edge surface with the dry or wet hand surface at the sensor location. This increases the device's adhesion to the hand surface and helps maintain the noninvasive blood glucose monitoring device with the sensor at the pulse location.

[0044] Let us explain the achievement of technical results.

[0045] The configuration of the declared device is similar to the configuration of the prototype.

[0046] To perform noninvasive blood glucose monitoring, a person sits still for 3 minutes. The hand is relaxed and placed, for example, on a table in front of the person. The pulse point on the hand should be level with the heart.

[0047] After which, the person determines the place on the arm where the pulse is felt above the radial artery.

[0048] After this, the device is pressed firmly against the pulse site, for example, on the left wrist, using the sensor of the right hand, so that the sensor is aligned with the radial artery at that location. Alternatively, the device can be pressed firmly against the pulse site, such as the right wrist, using the sensor of the left hand, so that the sensor is aligned with the radial artery at that location.

[0049] Next, we will describe the operation of the device when a person holds it with the fingers of the right hand.

[0050] The emitter and receiver of reflected radiation, located in the sensor, are aimed at the radial artery. Accuracy of the sensor's placement on the pulse palpation site is visually verified. Both the sensor and the pulse palpation site can be visually inspected.

[0051] The device's design allows for easy visual observation of the process of applying the sensor to the pulse site. The user can see both the sensor and the pulse site.

[0052] After this, the person sits still for 3 minutes, pressing the device's sensor against their hand. Then, they turn on the device. To do this, they turn on the power and control and data processing unit by pressing the "On" button on the device's body. (It's convenient if the power button is located on the side of the device.) The screen lights up.

[0053] The control unit checks the sensor's correct position relative to the radial artery (see Fig. 5). The check takes up to 3 minutes. If the sensor is correctly positioned, the user scrolls through the pages using their finger on the screen until they reach the page labeled "Take a measurement." Then, the user presses the "Take a measurement" button. The "Start" button lights up.

[0054] After which, the person presses the “Start” button with his finger.

[0055] The measurement has begun. The total measurement time is from 0.5 to 1.5 minutes.

[0056] The measurement results are then displayed on the screen, including sugar levels and other parameters, such as blood pressure, depending on the device settings.

[0057] If the sensor's placement is incorrect (i.e., its location on the arm does not match the location on the arm during the sensor testing), a message appears on the touchscreen prompting the sensor to be repositioned. The device is turned off.

[0058] After this, the sensor is repositioned over the radial artery (the pulse point). The patient sits still for 3 minutes, then turns on the device. The sensor placement continues until a message appears on the touchscreen indicating the device is ready for use. The ability to scroll through the screen pages becomes available. Testing of the prototype device revealed that initial setup requires at least 3-4 attempts. Each attempt takes 6 minutes. After this, the device is ready to measure blood sugar levels. Therefore, the prototype takes 18 minutes or more to perform the first measurement.

[0059] The prototype's shortcomings stem from the following. During the day, as a person walks and uses their hands, the sensor (also called the mobile unit in the prototype) shifts from its initial position. In this case, to perform a measurement, the mobile unit (the sensor) must be reset to its original position. Typically, a person uses their hands intensively throughout the day, causing the device to shift from its original position. A diabetic must measure their blood sugar levels multiple times a day—up to 10 times or more (and sometimes up to 20 times). This requires resetting the sensor and adjusting the device for operation the same number of times. This requires 3 or more hours of daily measurement time, with 10 measurements taken. This is due to the rotation of the device and strap relative to the arm and radial artery.

[0060] Importantly, using the prototype, a user cannot visually see the sensor or the pulse location. They are hidden from view by a strap.

[0061] The invention eliminates the need to wear the device on the wrist, which many people find inconvenient. Furthermore, statistics show that 3 out of 10 people dislike wearing a watch on their wrist.

[0062] Compared to the prototype, the device has been simplified by reducing weight by eliminating the strap and redesigning it as a keychain. The device can be carried in a pocket, purse, keychain, or on a chain around the neck.

[0063] The device provides visual verification of the correct placement of the sensor at the pulse measurement site during setup and operation. When placing the sensor at the pulse measurement site, the user observes the sensor and the location on the arm where it should be pressed. This improves the accuracy of sensor placement at the pulse measurement site, minimizing the risk of misplacing the sensor.

[0064] Experiments have shown that the claimed inventive solution virtually eliminates the need to reconfigure the device and sensor throughout the day. This reduces the time it takes to set up and implement noninvasive blood glucose monitoring by preventing erroneous readings.

[0065] Experiments demonstrated a 2.4-2.7-fold reduction in blood glucose measurement time (with ten measurements) compared to the prototype. Using a sensor with a rim containing protrusions and grooves or ridges on the ridge, the blood glucose measurement time was reduced by a factor of three (with ten measurements) compared to the prototype.

[0066] The invention allows the device to be held in place during setup and operation using the fingers of one hand, while simultaneously operating the touchscreen using a finger of the same hand. There is no possibility of the sensor and device slipping from the location where the pulse wave data is collected on the wrist artery.

[0067] In addition, a reduction in energy consumption for non-invasive monitoring of human blood glucose levels is ensured by precise orientation of the emitter and receiver to the artery and a reduction in the time it takes to prepare the device for operation.

[0068] The overall dimensions of the device, as stated in the invention, ensure ease of holding and operating it with the fingers of one hand.

[0069] Another important feature is that the wired connection from the sensor to the control and display module is shorter than in the prototype. In the prototype, the connection line runs through the strap and is kinked, reducing its reliability. In the proposed device, the connection line from the sensor to the control and display module runs exclusively within the housing. List of figures.

[0070] Fig. 1 shows a device for non-invasive monitoring of glucose levels in human blood. View from the touch screen side.

[0071] Fig. 2 shows a device for non-invasive monitoring of glucose levels in human blood. View A. The device's sensor contains an emitter and a radiation receiver.

[0072] Fig. 3 shows a device for non-invasive monitoring of human blood glucose levels in the form of a keychain. Experimental sample.

[0073] Fig. 4 shows a schematic cross-section of a human arm with the radial artery indicated, and also shows a device for non-invasive monitoring of glucose levels in human blood and a sensor with emitters and a receiver of radiation reflected from human tissue, located above the radial artery at the site of palpation of the pulse.

[0074] Fig. 5 shows a schematic cross-section of a human arm, indicating the radial artery. It also shows a device for noninvasively monitoring human blood glucose levels and a sensor with emitters and a receiver for reflecting radiation from human tissue, positioned above the radial artery at the site of pulse measurement. The beams emanating from the emitters into the arm, specifically the radial artery, are schematically shown, as are the reflected beams from the arm and the radial artery, directed toward the receiver.

[0075] Fig. 6 shows the dimensions of the device for non-invasive monitoring of human blood glucose levels and its components. The device is viewed from the touchscreen side.

[0076] Fig. 7 shows the dimensions of the device for non-invasive monitoring of human blood glucose levels and its components. The device is viewed from the side.

[0077] Fig. 8 shows the location on the left hand of the place where the pulse is felt using the index finger of the right hand.

[0078] Fig. 9 shows a diagram of how the sensor of the device for noninvasive monitoring of human blood glucose levels is held at the pulse point on the left hand using the fingers of the right hand and how the touchscreen is operated using the finger of the right hand. Fig. 10 shows the edge and part of the sensor with the receiver of the prototype device for noninvasive monitoring of human blood glucose levels.

[0079] Fig. 11 shows the rim and a portion of the sensor with a receiver of a specific embodiment of the claimed device for noninvasively monitoring glucose levels in human blood. The rim's ridge is formed with alternating projections and depressions along its length.

[0080] Fig. 12 shows a development of the ridge of the rim. The rim is made with projections and depressions alternating along its length.

[0081] Fig. 13 shows a development of the ridge of the side. The projection shows the extension element "A". The projection of the ridge is ribbed.

[0082] Fig. 14 shows the extension element “A” from Fig. 13. The projection of the side is ribbed.

[0083] Fig. 15 shows an experimental sample of a device for non-invasive monitoring of glucose levels in human blood.

[0084] Fig. 16 shows the determination of the location for palpating the pulse on the left hand.

[0085] Fig. 17 shows the measurement of glucose content using an experimental sample of a device for non-invasive monitoring of glucose content in human blood.

[0086] Fig. 18 shows an experimental sample of a device for non-invasive monitoring of glucose levels in human blood with grooves on its side surface.

[0087] Fig. 19 shows a scan of the sensor flange with the geometric dimensions of the protrusions and recesses on the ridge (on the edge) of the flange.

[0088] Fig. 20 shows a schematic representation of the sensor with dimensions.

[0089] Disclosure of invention.

[0090] The definition of terms is given in article / 2 / .

[0091] In terms of the sensor and its characteristics, the terms are given in article / 1 / .

[0092] The length of a noninvasive blood glucose monitoring device is the linear dimension of the housing in the longitudinal direction—along the longitudinal axis. In this particular case, it is the distance between its two outermost points.

[0093] To measure the length of a noninvasive blood glucose monitoring device, place it on a horizontal surface, such as a table. Then, measure the distance between the two outermost points of the device along its longitudinal axis.

[0094] The longitudinal axis of the device for non-invasive monitoring of glucose levels in human blood passes as shown in Fig. 6 (position 68). In a particular case, the longitudinal axis may pass through the center of mass of the device 69 (see Fig. 6), through the sensor, parallel to the plane of the touch screen.

[0095] The transverse axis of the device for noninvasively monitoring human blood glucose levels is shown in Fig. 6 (position 70). The transverse axis is perpendicular to the longitudinal axis and parallel to the surface of the touchscreen (or parallel to the tangent plane to the surface of the touchscreen). In a particular case, the transverse axis may pass through the center of mass of the device, perpendicular to the longitudinal axis, and parallel to the surface of the touchscreen. The longitudinal direction of the device as a whole and the housing in particular is the direction along the longitudinal axis of the device.

[0096] The transverse direction of the device as a whole and the body in particular is the direction along the transverse axis of the device.

[0097] The body width of a device for non-invasive monitoring of human blood glucose levels is the maximum dimension (i.e. the distance between the two most distant points) measured across the body (at a right angle to the longitudinal axis).

[0098] To measure the width of a noninvasive blood glucose monitoring device, place it on a horizontal surface, such as a table. Then, measure the maximum transverse dimension between the two outermost points of the device, along the device's transverse axis.

[0099] The thickness of the housing of a device for non-invasive monitoring of glucose levels in human blood is the distance between the upper and lower horizontal tangent planes to the device, measured when the device is placed on a horizontal surface, such as a table.

[0100] The touchscreen length is the linear dimension of the screen along the longitudinal axis of the device, that is, the distance between its two farthest points along the longitudinal axis of the device. Typically, the longitudinal axis of the screen coincides with the longitudinal axis of the device. In particular cases, it is the direction of the largest screen dimension along the longitudinal axis of the device.

[0101] The width of a touchscreen is the linear dimension of the screen in the direction perpendicular to the longitudinal axis of the device, that is, the distance between its two most distant points on the transverse axis of the device.

[0102] The sensor diameter is the maximum distance between two points from a set of points on the outer boundary of the sensor cross-section.

[0103] The sensor's working surface is the surface of the sensor where the emitter and receiver are located, as well as the flange separating the emitter from the receiver. The working surface is also known as the inner surface of the sensor. The inner surface of the sensor, or the inner surface of the sensor housing, is the surface that faces the user's hand during noninvasive blood glucose monitoring.

[0104] The light emitter and the light receiver are located on the working surface of the sensor and are directed outward in the direction of the axis of the device (see position 85, Fig. 7), perpendicular to the longitudinal axis 68 of the device and perpendicular to the transverse axis 70 of the device.

[0105] The lower end face 86 of the device housing for noninvasive blood glucose monitoring is the side that is located at the bottom when the longitudinal axis of the device and monitor is vertical. Sensor 26 is located at the lower end face of the housing on the rear face 84 of the device housing.

[0106] The upper end face of the device housing for noninvasive blood glucose monitoring is the side opposite the lower end face of the device housing. A rim is a boundary, specifically the boundary of the surface of the sensor housing containing the light receiver. In other words, it is the boundary of the light receiver on the sensor's working surface.

[0107] The ridge of the edge is the upper part of the edge, when the sensor is oriented in such a way that its emitter or emitters are directed away from the center of the earth - upwards (see article / 1 / ).

[0108] The front surface 83 of the noninvasive blood glucose monitoring device housing is the surface of the housing on which the touchscreen is located. The front surface may be referred to as the face, front side, or front surface.

[0109] The rear surface 84 of the housing of the device for non-invasive monitoring of glucose content in human blood is the surface opposite to the front surface.

[0110] On the rear surface 84 of the housing, at the lower end side 86 of the device housing, a sensor 26 is located. Moreover, it is preferable that the distance from the sensor to the lower end side is from 0.01 mm to 10 mm.

[0111] The term "at the bottom end of the device housing" means that the sensor is located close to the bottom end of the device or is positioned such that the distance from the sensor to the bottom end is between 0.001 mm and 20 mm. As noted above, the preferred distance is between 0.01 mm and 10 mm.

[0112] The side surface of the housing of the device for non-invasive monitoring of glucose content in human blood is the surface located between the front and back surfaces.

[0113] A device for non-invasive monitoring of glucose levels in human blood comprises a housing 1 (see Fig. 1), a control and display module located in the housing 1, a sensor 3 (see Fig. 2), a radiation emitter 4 and a receiver 5 of radiation reflected from human tissues, located in the sensor 3, and on the working surface 6 of the sensor 3 there is a rim 7 surrounding the light receiver 5 and separating it from the light emitter 4, and the control and display module comprises a power source 8, a control and data processing unit 2, a data display panel 9 made in the form of a touch screen made with the possibility of inputting and outputting information by touching it with a human finger, wherein the radiation emitter and the receiver of radiation reflected from human tissues are connected to the control and display module located in the housing via a wired communication line 10.

[0114] The control and data processing unit may be called the control unit.

[0115] Sensor 3 contains a housing 11. When storing the device, the sensor is covered with a cover 12.

[0116] The sensor can contain two emitters, three emitters, four emitters or more.

[0117] Fig. 2 shows a sensor with one emitter 4 and one receiver 5.

[0118] Fig. 3 shows a keychain-style device for noninvasively monitoring human blood glucose levels. This is an experimental prototype. The device comprises a housing 17, a touchscreen (not visible in the photograph), a connector 16, and a sensor 18.

[0119] The sensor 18 is located on the rear surface of the device body at the lower end side of the device body, wherein the light emitter and the light receiver are located on the working side of the sensor and are directed outward in the direction of the axis perpendicular to the longitudinal axis of the device and perpendicular to the transverse axis of the device;

[0120] The device body can be made elongated in the longitudinal direction, with a length from 60 mm to 100 mm, a width from 40 mm to 70 mm, a thickness from 10 mm to 20 mm, in addition, the length of the touch screen is from 40 mm to 70 mm, the width of the touch screen is from 40 mm to 70 mm, and the sensor is made with a diameter from 10 mm to 20 mm.

[0121] In Fig. 6 and 7 the following are indicated:

[0122] 19 – length of the device for non-invasive monitoring of glucose levels in human blood;

[0123] 20 - device width;

[0124] 21 - thickness of the device;

[0125] 22 - length of touch screen 24;

[0126] 23 - touch screen width 24; 24 - touch screen;

[0127] 25 - sensor diameter 26;

[0128] 27 - body;

[0129] 68 - longitudinal axis of the device for non-invasive monitoring of glucose content in human blood;

[0130] 69 - center of mass of the device for non-invasive monitoring of glucose content in human blood;

[0131] 70 - transverse axis of the device for non-invasive monitoring of glucose content in human blood;

[0132] 83 - the front side of the housing of the device for non-invasive monitoring of human blood glucose levels, the side on which the touch screen is located. The front side of the housing is the front side of the device for non-invasive monitoring of human blood glucose levels. The front side may be referred to as the front surface;

[0133] 84 - the back surface of the housing of the device for non-invasive monitoring of glucose levels in human blood, - the opposite side of the front surface or front side. The back surface of the housing is the back side of the device for non-invasive monitoring of glucose levels in human blood. The back surface may be called the back side of the housing of the device, the back side, or the back surface of the device);

[0134] 85 - an axis perpendicular to the longitudinal axis of the device for noninvasive monitoring of glucose levels in human blood and to the transverse axis of the device for noninvasive monitoring of glucose levels in human blood. This axis is simply called: the axis perpendicular to the longitudinal and transverse axes of the device. Or the axis perpendicular to the longitudinal and transverse axes of the device for noninvasive monitoring of glucose levels in human blood. Or the axis perpendicular to the longitudinal axis of the device and perpendicular to the transverse axis of the device;

[0135] 86 - the lower end side of the housing of the device for non-invasive monitoring of glucose levels in human blood;

[0136] 87 - the upper end face of the housing of the device for non-invasive monitoring of glucose levels in human blood; Fig. 4 shows a schematic cross-section of a human arm with the radial artery indicated, and also shows a device for non-invasive monitoring of glucose levels in human blood and a sensor with emitters and a receiver.

[0137] Sensor 28 is located on the lower end of the housing and contains emitters 32 and 33, as well as a radiation receiver 34.

[0138] The lower end side of the housing is the side that, in the working position, is directed towards the human hand 29. The sensor is placed on the surface of the hand 30 above the artery 31.

[0139] In this case, the light emitter 32 and the light emitter 33, as well as the light receiver 34 are located on the working side of the sensor 35 and are directed outward perpendicular to the longitudinal axis 36 of the device.

[0140] The light emitter 32, as well as 33 and the light receiver 34 are designed in such a way that when the sensor 28 is pressed against the hand 29 in the working position, the light emitter is designed with the ability to emit light into the hand 29 onto the radial artery 31, and the light receiver is designed with the ability to receive reflected light from the radial artery 31 of the human hand.

[0141] Fig. 5 schematically shows rays 37, 38 emanating from emitters 32 and 33 into the hand of a person 29, in particular, onto the radial artery 31, and shows reflected rays 39 from the hand of a person 29 and from the radial artery 31 towards the radiation receiver 34.

[0142] The device for non-invasive monitoring of glucose content in human blood 40 (see Fig. 8) is designed to be held in working condition by one hand of a person, in particular by the hand of an adult, and to be able to input and output information by touching the touch screen with a finger or fingers of the same hand (see Figs. 8 and 9).

[0143] The person uses the index finger 44 of the right hand to locate the pulse palpation site 42 on the left hand 43. The person holds the device 40 with the left hand. See Fig. 8. The device screen is shown at 45 in the figure.

[0144] In Fig. 9, a person presses the device 40 with the sensor 41 to the pulse palpation site 42 of the left hand 43. The sensor is held with the right hand. The user presses the buttons 46 of the touch screen 45 with the thumb 44 of the right hand. During preparation for operation and during operation, the device is configured to press the sensor 41 with the emitter and receiver to the pulse palpation site 42 on the radial artery of the hand.

[0145] In a particular embodiment of the invention, the device can be designed in such a way that while the sensor is in the working state on the hand, the light emitter is configured to emit light into the hand onto the radial artery at the base of the thumb of the human hand, or onto the radial artery of the wrist, or onto the radial artery of the forearm, and the receiver is configured to receive reflected light from the hand, namely, from the radial artery at the base of the thumb of the human hand, or from the radial artery of the wrist, or from the radial artery of the forearm.

[0146] In a particular embodiment of the invention, the device can be designed in such a way that when preparing it for operation, the place where the pulse is felt on the radial artery of the hand is moistened with water, or when preparing it for operation, the place where the pulse is felt on the radial artery of the hand is wiped dry.

[0147] Fig. 10 shows a portion of the sensor 47 of the prototype device. The radiation receiver 49 surrounds the edge 48. The emitter is not shown in the figure.

[0148] In a particular embodiment of the claimed invention, a device for non-invasive monitoring of glucose levels in human blood can be made in such a way that the ridge of the edge 51 (see Fig. 11) is made with projections 53, 54 and recesses 55, 56 alternating along its length.

[0149] In Fig. 11 the following are indicated:

[0150] 50 - sensor;

[0151] 51 - side;

[0152] 52 - radiation receiver.

[0153] In addition, grooves 67 can be made on the ridge of the side (see Fig. 12). Fig. 12 shows a development 66 of the side, side view.

[0154] In a particular embodiment of the invention, a device for non-invasively monitoring glucose levels in human blood may be designed such that the ridge of the edge 57 (see Fig. 13) is formed with projections 58, 59, 60 and recesses 61, 62 alternating along its length. The surfaces of the projections and recesses are ribbed. In Fig. 13, the extension element "A" is designated.

[0155] Fig. 14 shows the extension element "A". It is shown that grooves 63, 64, 65 are made on the surface of the projection 59.

[0156] Fig. 15 shows an experimental device for noninvasively monitoring human blood glucose levels. A student ruler lies on the table next to the device. The division value is 1 mm. The numbers on the ruler indicate centimeters: 1, 2, 3, etc.

[0157] Fig. 19 shows a scan of the sensor flange with the geometric dimensions of the protrusions and recesses on the flange edge.

[0158] In Fig. 19 the following are indicated:

[0159] 71 - width of the projection;

[0160] 72 - recess width;

[0161] 73 - height of the projection;

[0162] 74 - the length of the edge development;

[0163] 75 - side height.

[0164] Fig. 20 shows a diagram of the sensor with dimensions.

[0165] In Fig. 20 the following are indicated:

[0166] 76 - sensor housing;

[0167] 77 - side;

[0168] 78 - sensor diameter;

[0169] 79 - outer diameter of the rim;

[0170] 80 - inner diameter of the rim;

[0171] 81 - side height;

[0172] 82 – thickness of the sensor body.

[0173] In a specific embodiment of the invention, the device can be designed so that, during setup and operation, the device is configured to visually monitor the application of the sensor (including the process of applying the sensor) with the transmitter and receiver to the pulse location on the radial artery of the hand at the base of the thumb, or on the radial artery of the wrist, or on the radial artery of the forearm. For simplicity of presentation, we will refer to the device for non-invasive monitoring of human blood glucose levels as "the device."

[0174] For simplicity of presentation of the material, we will call the emitter of radiation and the receiver of radiation reflected from human tissue the emitter and receiver.

[0175] The device is designed to manually determine the location of the radial artery based on the pulse palpation site and to direct the emitter and receiver to it.

[0176] Light, a radiation visible to the human eye, is used as radiation. In addition, radiation invisible to the human eye can also be used.

[0177] The device operates as follows. A prototype of the device is shown in action.

[0178] First, the device is configured. The configuration of the proposed device is similar to that of the prototype. A user performs a series of invasive blood sugar measurements and simultaneously a series of non-invasive measurements using the device. Afterwards, the control and data processing unit processes the received data and configures the device for a specific user.

[0179] The device is then ready to perform non-invasive blood glucose monitoring.

[0180] To perform noninvasive blood glucose monitoring, a person sits still for 3 minutes. The arm is relaxed and placed, for example, on a table in front of the person. The pulse is felt at heart level.

[0181] After this, the person determines the place on the arm where the pulse is felt above the radial artery (see Fig. 16).

[0182] After this, the device is pressed firmly against the place where the pulse is being felt, for example, on the wrist of the left hand, using, for example, the sensor of the right hand, so that the sensor is opposite the radial artery in this place of the hand (see Fig. 17).

[0183] The emitter and receiver of reflected radiation, located in the sensor, are directed toward the radial artery (see Fig. 4). Accuracy of sensor placement on the pulse palpation site is visually verified. Both the sensor and the pulse palpation site can be visually inspected during the process of applying the sensor.

[0184] The device's design allows for easy visual observation of the process of applying the sensor to the pulse site. The user can see both the sensor and the pulse site.

[0185] After this, the person sits still for 3 minutes, holding the device's sensor against their hand. Then, they turn on the device. To do this, they turn on the power and control and data processing unit by pressing the "On" button on the device's body (the button is conveniently located on the side of the device). The screen lights up.

[0186] The control unit checks the correct position of the sensor relative to the radial artery (see Fig. 5). The check takes up to 3 minutes.

[0187] When the sensor is correctly located, the person scrolls through the “pages” on the screen with their finger until they reach the page that says: “Take a measurement.”

[0188] After which, the person presses the “Take measurement” button with his finger.

[0189] The "Start" button lights up.

[0190] After which, the person presses the “Start” button with his finger.

[0191] The measurement has begun. The measurement lasts from 0.5 to 1.5 minutes.

[0192] The screen then displays the measurement results: sugar level and other parameters, such as blood pressure. Depending on the device settings, the screen may display: sugar level, blood pressure, pulse, temperature, hemoglobin, cholesterol, uric acid, heart / lung / liver / brain function, etc.

[0193] If the sensor's placement is incorrect (i.e., its location on the arm does not match the location on the arm during the sensor testing), a message appears on the touchscreen prompting the sensor to be repositioned. The device is turned off.

[0194] After this, the sensor is repositioned over the radial artery (the site where the pulse is felt). The patient sits still for 3 minutes, then turns on the device. The sensor placement continues until a message appears on the touchscreen indicating the device is ready for use. The user can now scroll through the pages on the screen.

[0195] Testing of the prototype device revealed that initial setup requires at least three attempts. Each attempt takes up to 6 minutes. Afterward, the device is positioned on the user's hand, ready to measure blood sugar levels. Therefore, the prototype takes 18 minutes to perform the first measurement. The prototype's shortcomings include the following: During the day, while the user walks and uses their hands, the sensor moves from its initial position. In this case, to perform a measurement, the mobile sensor unit must be reset to its original position. The prototype lacks the ability to visually observe the sensor's positioning accuracy at the pulse measurement site. Both the sensor and the pulse measurement site are hidden from view by the strap and the device housing.

[0196] Typically, people work intensively with their hands throughout the day. This causes the device to shift from its original position. A diabetic patient must measure their blood sugar levels multiple times a day—up to 10 or more (and sometimes up to 20 times). This requires resetting the sensor and adjusting the device for operation the same number of times. This can take up to three hours of measurement time per day, with 10 measurements. This is due to the rotation of the device and strap relative to the arm and radial artery.

[0197] The invention eliminates the need to wear the device on the wrist, which many people find inconvenient. Compared to the prototype, the device has been simplified by reducing weight by eliminating the strap and making it a keychain. The device can be worn in a pocket or on a necklace.

[0198] The device provides visual verification of the sensor's placement at the pulse measurement site during setup and operation. When placing the sensor at the pulse measurement site, the user can see the sensor and the area on the arm where it should be pressed. This improves the accuracy of sensor placement. Errors in placing the sensor incorrectly are minimized and virtually eliminated.

[0199] Experiments have shown that this inventive solution virtually eliminates the need to reconfigure the device and sensor throughout the day. This reduces the time it takes to set up and implement noninvasive blood glucose monitoring by preventing erroneous readings.

[0200] Experiments demonstrated a 2.4-2.7-fold reduction in blood glucose measurement time (with ten measurements) compared to the prototype. Using a sensor with a rim containing protrusions and grooves or ridges on the ridge, the blood glucose measurement time was reduced by a factor of three (with ten measurements) compared to the prototype.

[0201] According to the invention, and this has been confirmed experimentally, it is possible to keep the device in working condition when preparing it for work and during work using one hand and simultaneously work with the touch screen using a finger of the same hand.

[0202] In addition, a reduction in energy consumption for non-invasive monitoring of human blood glucose levels is ensured by precise orientation of the emitter and receiver to the artery and a reduction in the time it takes to prepare the device for operation.

[0203] The overall dimensions of the device, as stated in the invention, ensure that it is easy to hold and operate with the fingers of one hand, both for an adult and for a child capable of operating the device.

[0204] Another important feature is that the wired connection from the sensor to the control and display module is shorter than in the prototype. In the prototype, the connection line runs through the strap and is kinked, reducing its reliability. In the proposed device, the connection line from the sensor to the control and display module runs exclusively within the housing.

[0205] Description of experiments with a device for non-invasive monitoring of glucose levels in human blood.

[0206] Ten volunteer test subjects, aged 16 to 65, participated in the experiments. Before each test, each subject tested the sensor and the device as a whole, and configured it for use on their hand.

[0207] After testing the device, the tester measured his blood sugar levels 10 times a day for one month.

[0208] The experiments tested whether the noninvasive blood glucose monitoring device could be held in place with one hand during setup and operation, while simultaneously operating the touchscreen with a finger of the same hand. The tests found that holding the device and operating the touchscreen with the fingers of one hand was possible.

[0209] It was found that the average time for ten measurements over a single day was 65-75 minutes, which is 2.4-2.7 times faster than the prototype. When using a sensor with a rim containing protrusions and indentations (or grooves) on the ridge, the average time for ten measurements over a single day was 60 minutes. This reduced the time required to measure blood glucose levels by a factor of three compared to the prototype.

[0210] The reduction in measurement time, compared to the prototype, results in reduced energy consumption for noninvasive blood glucose monitoring. This reduction is achieved through precise orientation of the emitter and receiver to the artery and reduced setup time for the noninvasive blood glucose monitoring device.

[0211] In the experiments, we additionally tested the knurling of the side surface of the device body to improve the grip of the device on human fingers (see Fig. 18).

[0212] Testers noted that the presence of ridges makes it more convenient to hold the device with the fingers of one hand.

[0213] In a formalized form, the presence of grooves on the device's body can be described as follows: alternating protrusions and depressions or grooves (specifically, transverse grooves) are provided on the side surfaces of the body and / or its back surface. This enhances the grip of the body on the hand and helps prevent the device's sensor from moving along the hand relative to the radial artery. This technical solution can be further used to enhance the technical result. Furthermore, this solution simultaneously promotes heat exchange between the body and the hand.

[0214] The experimental sample of the device has a body made elongated in the longitudinal direction, 80 mm long, 43 mm wide, 12 mm thick, the length of the touch screen is 50 mm, the width of the touch screen is 43 mm, the sensor is made with a diameter of 15 mm.

[0215] Fig. 15 shows an experimental device for noninvasively monitoring human blood glucose levels. A ruler is located nearby for determining the device's dimensions. The ruler has one division—1 mm—and is numbered in centimeters.

[0216] Fig. 16 shows the moment of time of determining the location of the pulse palpation on the left hand.

[0217] Fig. 17 shows a glucose measurement using an experimental device for noninvasive blood glucose monitoring. The person performing the measurement can visually observe the process of pressing the sensor to the pulse location (previously determined) on the arm.

[0218] The experimental device was designed with interchangeable sensors. The interchangeable sensors had different side designs.

[0219] The ridges of the replaceable sensors were made with projections and depressions alternating along their length, and grooves were also made on the ridges of the sides (see Figs. 11 - 14).

[0220] Table 2 presents the geometric characteristics of the sensors and flanges on the tested sensor housings. The sensor housing and flange material are plastic.

[0221] Table 3 presents the characteristics of the protrusions and recesses on the side of the experimental sensor variants.

[0222] Mock-ups were also constructed (see Table 1) to test their hand-holding comfort. The device housings are longitudinally elongated, with lengths ranging from 60 mm to 100 mm, widths ranging from 40 mm to 70 mm, and thicknesses ranging from 10 mm to 20 mm. Additionally, the touchscreens are 40 mm to 70 mm long and 40 mm to 70 mm wide. The sensor diameter ranges from 10 mm to 20 mm.

[0223] When testing the layouts, it was found that the above-mentioned range of sizes of the device and its elements are the most convenient for use by both adults and children.

[0224] In the invention, the sensor has a rim on its inner housing that surrounds the light receiver and separates it from the light emitter. In a particular embodiment, the rim's ridge is formed with alternating projections and depressions along its length, or the rim's ridge is ribbed.

[0225] In other words, the curb is designed with a variable height along its length. Moreover, as it extends, the curb's height increases and decreases.

[0226] In other words, along the length of the side, sections with a greater height alternate with sections with a lower side height.

[0227] This increases the adhesion force of the side to the person's hand and, thus, prevents the sensor from shifting from its original installation location.

[0228] When constructing a flange with a constant height along the flange length, as in the prototype, the term "flange height" is defined as follows. Flange height is the distance between the inner surface of the sensor and a plane constructed tangent to the flange edge / 1 / .

[0229] The height of the side may be variable along the length of the side, as in the claimed invention.

[0230] If the sidewall is made with a variable height along the entire length of the sidewall, then the term “average sidewall height” or the term “sidewall height in the longitudinal section of the sidewall” or “sidewall height in the i-th longitudinal section of the sidewall” can be used.

[0231] The term "maximum curb height" can also be used. The maximum curb height is the largest of the set of curb heights obtained by constructing multiple longitudinal curb sections.

[0232] The minimum height of the side is the minimum of the set of side heights obtained by constructing a set of longitudinal sections of the side.

[0233] The geometric characteristics of protrusions and recesses can be characterized by the empirical (obtained on the basis of experiments) coefficient “K”.

[0234] K = H / h, where H is the maximum height of the side; h is the minimum height of the side.

[0235] Conducted studies have shown that the coefficient K can take values ​​from 0.0001 to 0.5.

[0236] In a particular embodiment, the coefficient K can take values ​​from 0.0001 to 0.01, or in another particular embodiment, the coefficient K can take values ​​from 0.01 to 0.1, or in another particular embodiment, the coefficient K can take values ​​from 0.1 to 0.2, or in another particular embodiment, the coefficient K can take values ​​from 0.2 to 0.3, or in another particular embodiment, the coefficient K can take values ​​from 0.3 to 0.4, or in another particular embodiment, the coefficient K can take values ​​from 0.4 to 0.5.

[0237] The average height of the side is the arithmetic mean between the smallest and largest heights in the longitudinal sections of the side along its length.

[0238] In addition, when preparing it for operation and when the sensor is operating, the emitter and receiver are pressed to the place where the pulse is felt on the radial artery of the wrist.

[0239] This ensures increased operational efficiency of the device's sensor.

[0240] When testing several sensor variants with different rim designs, it was shown that making the rim ridge with alternating projections and depressions along its length or making the rim ridge with ribs allows for a reduction in the time it takes to measure blood glucose levels, compared to the prototype.

[0241] The main reason for the low efficiency of the prototype is the rotation of the sensor with the strap relative to the wrist and artery.

[0242] It would seem that the problem could be solved by tightening the strap more tightly. But this causes extreme discomfort.

[0243] Another option is to use adhesive—sticking the sensor and strap daily, for example, to your wrist. However, this solution causes discomfort throughout the day and is harmful to your skin.

[0244] From the above, it follows that the invention achieves its objective. It improves the operational efficiency of the device for noninvasive blood glucose monitoring by reducing setup and configuration time.

[0245] The technical results of the invention are also achieved.

[0246] There is no need to wear a device for non-invasive monitoring of blood glucose levels on a person’s arm.

[0247] Compared to the prototype, the device has been simplified by reducing its weight due to the absence of a strap and making it in the form of a keychain.

[0248] Visual verification of the correct placement of the noninvasive blood glucose monitoring device's sensor at the pulse site is provided. When placing the sensor at the pulse site, the user can see the sensor and the location on the arm where it should be pressed. This improves the accuracy of sensor placement at the pulse site, minimizing the risk of misplacing the sensor.

[0249] It is possible to hold the device for non-invasive monitoring of human blood glucose levels in a working state when preparing it for operation and during operation using one hand and simultaneously operate the touch screen using a finger of the same hand.

[0250] A reduction in energy consumption for non-invasive monitoring of human blood glucose levels is achieved by precisely orienting the emitter and receiver to the artery and reducing the time it takes to prepare the device for non-invasive monitoring of human blood glucose levels for operation.

[0251] A specific technical result of creating a ridge on the edge with alternating protrusions and depressions or with ribs is an increase in the contact area of ​​the edge surface with the dry or wet hand surface at the sensor location. This helps maintain the noninvasive blood glucose monitoring device with the sensor at the pulse location.

[0252] Table 1

[0253] Dimensions of the device layout for non-invasive monitoring of glucose levels in human blood and its components Table 2

[0254] Geometric characteristics of sensors and flanges on the sensor body submitted for testing.

[0255] The sensor body and rim are made of plastic.

[0256] Table 3

[0257] Characteristics of the protrusions and recesses on the side of the experimental sensor variants Literature.

[0258] 1. Tikhonenko D.O., Tikhonenko O.O., Lobko V.P. NEW DEVELOPMENTS IN THE FIELD OF WRIST DEVICES FOR NON-INVASIVE MONITORING OF GLUCOSE CONTENT IN HUMAN BLOOD, AS WELL AS FOR MONITORING OTHER HUMAN HEALTH PARAMETERS. TERMS AND DEFINITIONS. Higher school: scientific research. Proceedings of the Interuniversity International Congress (Moscow, October 13, 2023). Volume 1. - Moscow: Infinity Publishing House, 2023, 61-98 pp., BBK 65, ISBN 978-5-905695-53-

[0259] 7, DOI 10.34660 / INF.2023.68.11.381 https: / / studylib.net / doc / 27163933 / kongress- 13-oktvabrya-2023-tom- 1

[0260] 2. Tikhonenko D.O., Tikhonenko O.O., Lobko V.P. New developments in the field of non-invasive monitoring of glucose content in human blood, as well as monitoring of other parameters of human health. Control devices in the form of a key fob. Terms and definitions. Higher school: scientific research. Proceedings of the Interuniversity International Congress (Moscow, March 21, 2024). - Moscow: Infinity Publishing House, 2024, 77-126 pp., BBK 65, B42, ISBN 978-5-905695-53-

[0261] 7, DOI 10.34660 / INF.2024.46.11.006 https: / / studylib.net d / JW3R2

[0262] 3. Accofrisk Smartwatch. https: / / accofrisk.com / ru / non-invasive-smartwatch

Claims

Invention formula 1. A device for non-invasively monitoring the glucose content in human blood, comprising a housing, a control and display module located in the housing, a sensor, a radiation emitter and a receiver of radiation reflected from human tissue, located in the sensor, and light is used as radiation, and on the working surface of the sensor there is a rim surrounding the light receiver and separating it from the light emitter, and the control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, and the touch screen is designed with the possibility of inputting and outputting information by touching it with a human finger, wherein the radiation emitter and the receiver of radiation reflected from human tissue are connected to the control and display module located in the housing by means of a wired communication line, characterized in that the housing of the device is made elongated in the longitudinal direction, with a length of 60 mm to 100 mm,a width of 40 mm to 70 mm, a thickness of 10 mm to 20 mm, in addition, the length of the touch screen is from 40 mm to 70 mm, the width of the touch screen is from 40 mm to 70 mm, and the sensor is made with a diameter of 10 mm to 20 mm; and the sensor is located on the rear surface of the device housing at the lower end side of the device housing, wherein the light emitter and the light receiver are located on the working side of the sensor and are directed outward in the direction of an axis perpendicular to the longitudinal axis of the device and perpendicular to the transverse axis of the device; and when preparing for operation and during operation, the device is configured to press the sensor with the emitter and receiver to the site of palpation of the pulse on the radial artery of the arm; and, in addition, the device is configured to visually control the pressing of the sensor with the emitter and receiver to the site of palpation of the pulse on the radial artery of the arm; wherein the light emitter and the light receiver are made in such a way that, When the sensor is pressed against the hand in the working position, the light emitter is configured to emit light into the hand onto the radial artery, and the light receiver is configured to receive reflected light from the radial artery of the human hand; and, in addition, the device for non-invasive monitoring of glucose content in human blood is configured to be held in the working position by one hand of the person and to be able to input and output information by touching the touch screen with a finger of the same hand.

2. The device according to claim 1, characterized in that while the sensor is in the working position, pressed to the hand, the light emitter is configured to emit light into the hand onto the radial artery at the base of the thumb of the human hand, or onto the radial artery of the wrist, or onto the radial artery of the forearm, and the receiver is configured to receive reflected light from the hand, namely, from the radial artery at the base of the thumb of the human hand, or from the radial artery of the wrist, or from the radial artery of the forearm.

3. The device according to paragraph 1, characterized in that the ridge of the side is made with projections and depressions alternating along its length, or ribbing is made on the ridge of the side.

4. The device according to paragraph 1, characterized in that the ridge of the side is made with projections and depressions alternating along its length and that grooves are made on the ridge of the side.

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