Insecticidal and acaricidal composition

Abstract

The present invention relates to an insecticidal and acaricidal composition. The composition contains active component A and active component B, wherein the active component A is selected from compound I; the active component B is selected from one or more of bionic juvenile hormones, chitin biosynthesis inhibitors affecting CHS1, type-1 chitin biosynthesis inhibitors, ecdysone receptor agonists, nicotinic acetylcholine receptor competitive modulators, ryanodine receptor modulators, nicotinic acetylcholine receptor allosteric modulators, glutamate-gated chloride channel allosteric modulators, sodium channel modulators, voltage-dependent sodium channel blockers, inhibitors, trifluoroethyl sulfide acaricides, other insecticides and acaricides, etc.; and the active component A has a structure as follows. The composition of the present invention has advantages such as obvious synergistic effects and delayed resistance development, and can be used for controlling a variety of pests.

Description

Insecticide and acaricide composition

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the rights of Chinese patent applications No. 202410386276.1 filed on April 1, 2024, No. 202410385907.8 filed on April 1, 2024, No. 202410386163.1 filed on April 1, 2024, No. 202410385619.2 filed on April 1, 2024, No. 202410385668.6 filed on April 1, 2024, No. 202410385792.2 filed on April 1, 2025, and No. 202410385793.1 filed on April 1, 2025 The present invention relates to Chinese patent application No. 202510386010.1 filed on March 30, 2025, Chinese patent application No. 202510386007.X filed on March 30, 2025, Chinese patent application No. 202510385993.7 filed on March 30, 2025, Chinese patent application No. 202510386005.0 filed on March 30, 2025, Chinese patent application No. 202510385991.8 filed on March 30, 2025, and Chinese patent application No. 202510386000.8 filed on March 30, 2025, the contents of which are incorporated herein by reference. Technical Field

[0003] The invention belongs to the field of insecticides and acaricides, and relates to an insecticide and acaricide composition. Background Art

[0004] In crop production, such as agriculture and horticulture, pests and diseases remain significant. Due to biodiversity and the simultaneous occurrence of multiple pests and diseases, the field of plant protection continues to demand the development of new insecticides and acaricides with improved activity, lower dosages, and improved environmental friendliness. Insecticides and acaricides containing a single active ingredient can easily lead to insecticide resistance if used continuously for pest control. Mixing insecticides and acaricides containing two or more active ingredients into a blend plays an important role in expanding the insecticide spectrum, combating both pests and diseases, controlling vector insects to manage viral diseases, and reducing pesticide application costs for farmers. It can also delay the development of insecticide resistance in pests. Although mixtures can delay resistance, the use of two active ingredients alone is not always predictable. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the present invention aims to provide an insecticide and acaricide composition in order to meet the demand for increasingly improved insecticides and acaricides and continuously updated varieties in the fields of agriculture, forestry and urban sanitation for pest control.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] The invention provides an insecticide and acaricide composition, which contains an active component A and an active component B; wherein the active component B is selected from bionic juvenile hormones, chitin biosynthesis inhibitors affecting CHS1, chitin biosynthesis inhibitor type 1, ecdysone receptor agonists, nicotinic acetylcholine receptor (nAChR) competitive modulators, ryanodine receptor modulators, nicotinic acetylcholine receptor (nAChR) allosteric modulators, glutamate-gated chloride ion channel (GluCl) allosteric modulators, sodium channel modulators, voltage regulators, One or more of: a mitochondrial adenosine triphosphate (ATP) synthase inhibitor, a mitochondrial electron transport complex (III) inhibitor, a mitochondrial electron transport complex (I) inhibitor, an acetyl-CoA carboxylase inhibitor, a mitochondrial electron transport complex (II) inhibitor, a trifluoroethyl sulfide acaricide, and other insecticides and acaricides; the active component A is selected from compound I or its stereoisomers, and the structure of compound I is as follows:

[0008] In some embodiments, the weight ratio between active component A and active component B is 99:1-1:99, for example, 1:99, 1:90, 1:80, 1:70, 1:60, 1:50, 1:40, 1:30, 1:20, 1:10, 1:8, 1:5, 1:4, 1:3, 1:2, 1:1, 99:1, 90:1, 80:1, 70:1, 60:1, 50:1, 40:1, 30:1, 20:1, 10:1, 8:1, 5:1, 4:1, 3:1, 2:1 and any value in a range consisting of any two values.

[0009] In some preferred embodiments, the weight ratio between active component A and active component B is preferably 80:1-1:80.

[0010] In some embodiments, the biomimetic juvenile hormones are selected from one or more of methoprene, methoprene, methoprene, fenoxycarb, and pyriproxyfen.

[0011] In some typical embodiments, the biomimetic juvenile hormone is selected from pyriproxyfen.

[0012] In some embodiments, the chitin biosynthesis inhibitors affecting CHS1 are selected from one or more of diflubenzuron, fluazifop, lufenuron, fluazifop, and flubendiamide.

[0013] In some typical embodiments, the chitin biosynthesis inhibitors affecting CHS1 are selected from lufenuron.

[0014] In some embodiments, the chitin biosynthesis inhibitor type 1 is selected from buprofezin and / or cyromazine.

[0015] In some exemplary embodiments, the chitin biosynthesis inhibitor type 1 is selected from buprofezins.

[0016] In some embodiments, the ecdysone receptor agonists are selected from one or more of chlorfenapyr, chlorfenapyr, methoxyfenapyr, and tebufenozide.

[0017] In some typical embodiments, the ecdysone receptor agonist is selected from methoxyfenozide.

[0018] In some embodiments, the nicotinic acetylcholine receptor (nAChR) competitive modulator is selected from one or more of pyridapord, thiamethoxam, acetamiprid, dinotefuran, clothianidin, nitenpyram, thiacloprid, chlorothiazolin, flonicamid, benzopyrene, sulfone thiamethoxam, nicotine, sulfoxaflor, flupyradone, trifluanid, dichlorothiazolin and flufenac.

[0019] In some typical embodiments, the nicotinic acetylcholine receptor (nAChR) competitive modulator is selected from one or more of imidacloprid, sulfoxaflor and trifluanid.

[0020] In some embodiments, the ryanodine receptor modulators are selected from at least one of flubendiamide, tetracyclanil, cyclic bromofenapyr, tetracyclanil, chlorantraniliprole, cyantraniliprole and chlorofluanid, that is, the ryanodine receptor modulators can be selected from one or more of flubendiamide, cyclic bromofenapyr, tetracyclanil, chlorantraniliprole, cyantraniliprole and chlorofluanid.

[0021] In some typical embodiments, the ryanodine receptor modulators are selected from chlorantraniliprole and / or cyantraniliprole.

[0022] In some embodiments, the nicotinic acetylcholine receptor (nAChR) allosteric modulators are selected from spinetoram and / or spinosyn.

[0023] In some exemplary embodiments, the nicotinic acetylcholine receptor (nAChR) allosteric modulators are selected from spinetoram.

[0024] In some embodiments, the glutamate-gated chloride channel (GluCl) allosteric modulators are selected from one or more of avermectin, avermectin benzoate, lepidomectin, and mibemectin.

[0025] In some typical embodiments, the glutamate-gated chloride channel (GluCl) allosteric modulators are selected from avermectins.

[0026] In some embodiments, the sodium channel modulator is selected from cypermethrin, lambda-cyhalothrin, fenpropathrin, fenvalerate, flucythrinate, flumethrin, beta-cyfluthrin, cyfluthrin, bifenthrin, deltamethrin, acrinathrin, cis-cypermethrin, alpha-cypermethrin), bifenthrin, cyhalothrin, permethrin, fluvalinate, allethrin, bioallethrin, cycloprothrin, gamma-cyhalothrin, theta-cypermethrin, zeta-cypermethrin, cyphe nothrin), empenthrin, esfenvalerate, imiprothrin, meperfluthrin, metofluthrin, dimefluthrin, prallethrin, phenothrin, resmethrin, bioresmethrin, cismethrin, tefluthrin, tetramethrin amethrin), tetramethylfluthrin, tralomethrin, beta-cypermethrin, ethofenprox, transfluthrin, esdépalléthrine, barthrin, bioethanomethrin, brofenvalerate, brofluthrinate, bromethrin, butethrin,Chlorempenthrin, cyclethrin, cyhalothrin, lambda-cyhalothrin, dimethrin, d-fanshiluquebingjuzhi, fenfluthrin, fenpirithrin, esfenvalerate, furamethrin, imiprothrin, japothrins, kadethrin, methotrexate, pentmethrin, biopermethrin, and fenfluthrin one or more of: proparthrin, resmethrin, terallethrin, tralocythrin, valerate, flufenprox, halfenprox, sulfoxime, thiofluoximate, flumethrin, furethrin, heptafluthrin, momfluorothrin, transpermethrin, profluthrin, pyresmethrin, protrifenbute, silafluofen, DDT, and methoxychlor;

[0027] In some exemplary embodiments, the sodium channel modulators are selected from cypermethrin.

[0028] In some embodiments, the voltage-dependent sodium channel blockers are selected from indoxacarb and / or metaflumizone.

[0029] In some typical embodiments, the voltage-dependent sodium channel blockers are selected from indoxacarb.

[0030] In some embodiments, the inhibitors affecting the growth of chitin synthase 1 (CHS1) mites are selected from one or more of clofentezine, fluazifop, hexythiazox, and etoxazole.

[0031] In some typical embodiments, the inhibitors affecting the growth of chitin synthase 1 (CHS1) mites are selected from etoxazole.

[0032] In some embodiments, the mitochondrial adenosine triphosphate (ATP) synthase inhibitors are selected from one or more of diafenthiuron, azoxatin, cyhexatin, fenbutatin, propargite, and fenfosfoline.

[0033] In some typical embodiments, the mitochondrial adenosine triphosphate (ATP) synthase inhibitors are selected from diafenthiuron and / or propargite.

[0034] In some embodiments, the mitochondrial electron transport complex (III) inhibitors are selected from one or more of hydrazone, acequinoxaline, pyrimidifen, and bifenazate.

[0035] In some typical embodiments, the mitochondrial electron transport complex (III) inhibitors are selected from bifenazate.

[0036] In some embodiments, the mitochondrial electron transport complex (I) inhibitors are selected from one or more of fenazaquin, fenpyrad, pyridaben, pyrimidifen, tebufenpyrad, tolfenpyrad and rotenone.

[0037] In some typical embodiments, the mitochondrial electron transport complex (I) inhibitors are selected from pyridaben.

[0038] In some embodiments, the acetyl-CoA carboxylase inhibitors are selected from one or more of spirodiclofen, spiromesifen, methylphenidate, and spirotetramat.

[0039] In some typical embodiments, the acetyl-CoA carboxylase inhibitors are selected from spirodiclofen and / or spiromesiclofen.

[0040] In some embodiments, the mitochondrial electron transport complex (II) inhibitors are selected from one or more of cypermethrin, ethoxyfen, cyflumetofen and pyrazoanilide;

[0041] In some typical embodiments, the mitochondrial electron transport complex (II) inhibitors are selected from ethidiumbide.

[0042] In some embodiments, the trifluoroethyl sulfide acaricide is selected from one or more of bentioflumin, bisulflufen, sulfiflumin, and flupentiofenox.

[0043] In some typical embodiments, the trifluoroethyl sulfide acaricide is selected from bentioflumin.

[0044] In some embodiments, the other insecticides are selected from one or more of azadirachtin, cryolite, boric acid, sulfuryl fluoride, sulfanilamide, sulfamethoxam, sulfamethoxam sodium, amitraz, and veratridine.

[0045] In some typical embodiments, the other class of insecticides and acaricides is selected from the group consisting of veratridines.

[0046] In some embodiments, the active component B is selected from one or more of pyriproxyfen, lufenuron, buprofezin, and methoxyfenozide.

[0047] In some embodiments, the weight ratio between active component A and active component B is 30:1-1:60.

[0048] In some embodiments, the active component A is compound I, and the active component B is selected from pyriproxyfen; the weight ratio of the two active components is 20:1-1:50.

[0049] In some embodiments, the active component A is compound I, and the active component B is selected from lufenuron; the weight ratio of the two active components is 20:1-1:50.

[0050] In some embodiments, the active component A is compound I, and the active component B is selected from buprofezin; the weight ratio of the two active components is 20:1-1:50.

[0051] In some embodiments, the active component A is compound I, and the active component B is selected from methoxyfenozide; the weight ratio of the two active components is 20:1-1:50.

[0052] In some embodiments, the active component B is selected from one or more of imidacloprid, sulfoxaflor and trifluanid.

[0053] In some embodiments, the weight ratio between active component A and active component B is 30:1-1:60.

[0054] In some embodiments, the active component A is compound I, and the active component B is selected from imidacloprid; the weight ratio of the two active components is 30:1-1:30.

[0055] In some embodiments, the active component A is selected from Compound I or its stereoisomers, and the active component B is selected from sulfoxaflor; the weight ratio of the two active components is 5:1-1:40.

[0056] In some embodiments, the active component A is selected from Compound I or its stereoisomers, and the active component B is selected from trifluridine; the weight ratio of the two active components is 20:1-1:50.

[0057] In some embodiments, the active component B is selected from chlorantraniliprole and / or cyantraniliprole.

[0058] In some embodiments, the weight ratio between active component A and active component B is 80:1-1:80.

[0059] In some embodiments, the active component A is compound I, and the active component B is selected from chlorantraniliprole; the weight ratio of the two active components is 10:1-1:80.

[0060] In some embodiments, the active component A is compound I, and the active component B is selected from cyantraniliprole; the weight ratio of the two active components is 10:1-1:10.

[0061] In some embodiments, the active component B is selected from spinetoram and / or avermectin.

[0062] In some embodiments, the weight ratio between active component A and active component B is 80:1-1:30.

[0063] In some embodiments, the active component A is compound I, and the active component B is selected from spinetoram; the weight ratio of the two active components is 2:1-1:10.

[0064] In some embodiments, the active component A is compound I, and the active component B is selected from avermectin; the weight ratio of the two active components is 80:1-1:11.

[0065] In some embodiments, the active component B is selected from cypermethrin and / or indoxacarb.

[0066] In some embodiments, the weight ratio between active component A and active component B is 20:1-1:80.

[0067] In some embodiments, the active component A is compound I, and the active component B is selected from cypermethrin; the weight ratio of the two active components is 5:1-1:80.

[0068] In some embodiments, the active component A is compound I, and the active component B is selected from indoxacarb; the weight ratio of the two active components is 10:1-1:40.

[0069] In some embodiments, the active component B is selected from one or more of etoxazole, veratridine, pyridaben, propargyl, bifenazate, spirocyclopentyl, ethoxaclonil and benzylfenac.

[0070] In some embodiments, the weight ratio between active component A and active component B is 30:1-1:80.

[0071] In some embodiments, the active component A is compound I, and the active component B is selected from etoxazole; the weight ratio of the two active components is 30:1-1:30.

[0072] In some embodiments, the active component A is compound I, and the active component B is selected from veratridine; the weight ratio of the two active components is 30:1-1:30.

[0073] In some embodiments, the active component A is compound I, and the active component B is selected from pyridabenz; the weight ratio of the two active components is 30:1-1:30.

[0074] In some embodiments, the active component A is compound I, and the active component B is selected from diafenthiuron or propargite; the weight ratio of the two active components is 30:1-1:80.

[0075] In some embodiments, the active component A is compound I, and the active component B is selected from bifenazate; the weight ratio of the two active components is 30:1-1:80.

[0076] In some embodiments, the active component A is compound I, and the active component B is selected from spirodiclofen or spiromesiclofen; the weight ratio of the two active components is 4:1-1:25.

[0077] In some embodiments, the active component A is compound I, and the active component B is selected from ethidium bromide; the weight ratio of the two active components is 20:1-1:20.

[0078] In some embodiments, the active component A is selected from Compound I or its stereoisomers, and the active component B is selected from benzyltetramine; the weight ratio of the two active components is 20:1-1:40.

[0079] Furthermore, the composition is mixed with a carrier and any auxiliary agent to prepare a preparation containing the composition. The cumulative content of the active ingredient of the composition in the preparation is between 0.5wt% and 95wt%. Preferably, the cumulative content of the active ingredient in the preparation is between 1% and 85%.

[0080] The carrier of the present invention may be solid or liquid, and any carrier commonly used in formulating pesticide compositions can be used.

[0081] In the present invention, suitable solid carriers include: minerals, plants, synthetic fillers and inorganic salts. Minerals include silicates, carbonates, sulfates and oxides. Silicates include kaolin, sepiolite, pearl clay, montmorillonite, mica, vermiculite, pyrophyllite and talc. Carbonates include calcium carbonate and dolomite. Sulfates include ammonium sulfate, sodium sulfate and calcium sulfate. Oxides include quicklime, magnesium lime and diatomaceous earth. Plants include citrus residue, corn cob cobs, husk powder, rice husk, soybean straw powder, tobacco powder, walnut shells and sawdust. Synthetic fillers include precipitated calcium carbonate hydrate, precipitated calcium carbonate and white carbon black. Inorganic salts include potassium chloride and sodium chloride.

[0082] In the present invention, the liquid carrier includes water and an organic solvent. When the active ingredient is a suspensoid, the organic solvent plays a solubilizing and antifreezing role. Suitable organic solvents include aromatic hydrocarbons such as benzene, xylene, toluene, alkylbenzenes, alkylnaphthalenes, and chlorinated aromatic hydrocarbons; chlorinated aliphatic hydrocarbons such as vinyl chloride, chloroform, dichloromethane, chloroform, carbon tetrachloride, and polychlorinated ethanes; aliphatic hydrocarbons such as petroleum fractions, cyclohexane, light mineral oil, and paraffin. Alcohols such as methanol, ethanol, isopropanol, butanol, isobutanol, ethylene glycol, propylene glycol, glycerol, fatty alcohols, etc.; ethers such as methyl glycol ether, ethyl glycol ether, and petroleum ether. Ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, isophorone, and N-methyl-pyrrolidone; special solvents such as dimethylformamide, dimethyl sulfoxide, polyethylene glycol, and capronitrile; vegetable oils and methylated vegetable oils. The above organic solvents may be used alone or in combination, or may be mixed with water.

[0083] In the present invention, the auxiliary agent may include one or more of a surfactant, a defoaming agent, a thickener, a suspending agent and an antifreeze agent as needed, and may also include other auxiliary agents commonly used in the industry as needed.

[0084] In the present invention, the surfactant can be an emulsifier, dispersant, stabilizer or wetting agent; it can be ionic or nonionic. Suitable surfactants include: sodium salts and calcium salts of polyacrylic acid and lignin sulfonic acid; condensation products of fatty acids or fatty amines containing at least 12 carbon atoms in the molecule with ethylene oxide and / or propylene oxide; fatty acid esters of glycerol, dodecanol-1, tetradecanol-1, sorbitol, sucrose or pentaerythritol; and condensation products thereof with ethylene oxide and / or propylene oxide; sulfates or sulfonates of their condensation products; alkali metal or alkaline earth metal salts of sulfuric acid or sulfonic acid containing at least 10 carbon atoms in the molecule, preferably sodium salts, such as sodium lauryl sulfate, sodium secondary alkyl sulfate, sodium salt of sulfonated castor oil, sodium alkyl sulfonate and sodium dodecylbenzene sulfonate; polymers of ethylene oxide, and copolymers of ethylene oxide and propylene oxide.

[0085] In the present invention, the emulsifier includes nonionic emulsifiers and anionic emulsifiers. Nonionic emulsifiers are preferably nonylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, styrylphenyl polyoxyethylene ether, alkylphenol formaldehyde resin polyoxyethylene ether, terminal hydroxy polyoxyethylene polyoxypropylene ether, styrylphenol formaldehyde resin polyoxyethylene polyoxypropylene ether, and castor oil polyoxyethylene ether. Anionic emulsifiers mainly include calcium dodecylbenzene sulfonate, triphenyl ethyl phenol polyoxyethylene ether phosphate amine salt, nonylphenol polyoxyethylene ether phosphate amine salt, and castor oil polyoxyethylene ether phosphate amine salt.

[0086] In the present invention, the dispersant includes: one or more of: sodium salt of acrylic acid homopolymer, disodium salt of maleic acid, sodium salt of naphthalenesulfonic acid formaldehyde condensate, rosin block polyoxyethylene ether polyoxypropylene ether sulfonate, terminal hydroxyl polyoxyethylene polyoxypropylene ether block copolymer, triphenyl phenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, and sodium salt of p-hydroxyphenyl lignin sulfonate.

[0087] The wetting agent of the present invention comprises one or a combination of two or more of fatty alcohol polyoxyethylene ether, naphthalene sulfonate, sodium lauryl sulfate and alkylphenol resin polyoxyethylene ether sulfate.

[0088] The thickener of the present invention comprises one or more of xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethyl cellulose, gum arabic, gelatin and polyvinyl alcohol.

[0089] The defoaming agent of the present invention includes foaming agents, silicones, C8-10 fatty alcohols, C10-20 saturated fatty acids and amides.

[0090] The fungicide and insecticide of the present invention can be formulated into any dosage form permitted in agriculture as needed, such as powdery preparations, granular preparations, dispersible powdery preparations, dispersible granular preparations, dispersible sheet preparations, soluble solid preparations, soluble liquid preparations, oil preparations, ultra-low volume preparations, dispersible liquid preparations, emulsion preparations, suspension preparations, suspoemulsions or seed coating preparations.

[0091] The present invention also provides an application of the insecticide and acaricide composition, and the application of the insecticide and acaricide composition in the preparation of an insecticide and acaricide for controlling agricultural pests or urban pests.

[0092] In the present invention, the agricultural pests include armyworms, beet armyworms, cotton bollworms, cutworms, cabbage armyworms, apple leaf rollers, rice leaf rollers, corn borers, striped stem borers, diamondback moths, cabbage worms, gypsy moths, East Asian migratory locusts, underground pests, leaf miners, leafminers, aphids, leafhoppers, flower scale insects, potato beetles, flea beetles, thrips, blind bugs, cinnabar spider mites, hawthorn spider mites, citrus rust mites, apple spider mites, two-spotted spider mites, gall mites, flour mites, etc., and urban pests include termites, cockroaches, ants, flies, mosquitoes, etc. When used to control agricultural pests, it can be applied to fruit trees, cereals, beans, vegetables, and flowers. It can be used on fruit trees such as apples, pears, citrus, and lychees; cereals such as wheat and rice; beans such as soybeans and kidney beans; cotton; and vegetables such as cabbage, cauliflower, Chinese cabbage, rapeseed, tomatoes, and peppers. When used to control urban pests, it can be used in homes, public places, offices, and on trees and dams infested with termites.

[0093] The present invention further provides a method for using the insecticide and acaricide composition, comprising applying an effective dose of the prepared insecticide and acaricide to the pests to be controlled or to the medium in which they grow. A generally suitable effective dose is 10 to 500 grams per hectare, with a preferred effective dose being 15 to 100 grams per hectare.

[0094] The beneficial effects of the present invention are as follows:

[0095] 1. The present invention adopts compounds with different mechanisms of action in insecticide and acaricide to be mixed in a specific proportion, which work in coordination with each other to control pests, delay the occurrence of pest resistance, and improve the control effect on resistant populations. It shows obvious synergistic effect in insecticide and acaricide, and improves the control effect of single active ingredient compounds in the composition on pests. At the same time, the synergistic effect of the combination of the present invention is not linearly related to that of a single agent.

[0096] 2. The dosage of the composition of the present invention in killing insects and acarids is significantly lower than the dosage of a single compound in the composition, thereby reducing the cost of use and reducing environmental pollution. DETAILED DESCRIPTION

[0097] The following examples may enable those skilled in the art to more fully understand the present invention, but the present invention is not limited to the scope of the examples.

[0098] Indoor biological activity assay

[0099] Example 1 Determination of the synergistic effect of a composition containing Compound I on second-instar larvae of Plutella xylostella

[0100] Test subjects: Second-instar larvae of the diamondback moth, a sensitive strain reared indoors.

[0101] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0102] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0103] Experimental method: Select fresh cabbage leaves grown in the greenhouse, use a hole punch to cut the cabbage leaves into round leaflets with a diameter of 3 cm, put them into the prepared solution and immerse them for 10 seconds. After natural drying in the shade, place them in a culture dish with a diameter of 9 cm with filter paper, and inoculate neatly with healthy test insects. Each treatment has 20-25 heads, and each treatment is repeated 4 times. A blank control is also set up.

[0104] Based on the concept of toxicity combination proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated by the following formula: P = P m +P n (1-P m )

[0105] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0106] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0107] The results are shown in Table 1.

[0108] Table 1 Synergistic effect of compound I mixed with pyriproxyfen and other four pesticides on diamondback moth larvae

[0109] Example 2 Determination of the synergistic effect of the composition containing Compound I on western flower thrips larvae

[0110] Test subjects: Western flower thrips larvae, sensitive strain reared indoors.

[0111] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0112] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0113] Test Method: Add 0.5 mL of the prepared acetone solution to a glass tube (1 cm inner diameter, 10 cm length). Roll the tube repeatedly on a flat surface until the acetone solution evaporates completely. Immerse cabbage leaves in the corresponding concentration of solution for 15 seconds, let dry, and then place them in the glass tube. Catch 20-30 western flower thrips larvae in the tube. Each treatment is replicated four times. After treatment, observe in a constant temperature observation room. After 72 hours, count the number of live insects and calculate mortality.

[0114] The results are shown in Table 2.

[0115] Table 2 Synergistic effect of compound I mixed with sulfoxaflor and trifluanid against western flower thrips larvae

[0116] Example 3 Determination of the synergistic effect of the composition containing compound I on Tetranychus cinnabarinus

[0117] Test subjects: Tetranychus cinnabarinus, adult mites, sensitive strain reared indoors.

[0118] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0119] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0120] Test Method: Activity against adult Tetranychus cinnabarinus mites was determined using a potted seedling spray method. First, 40-60 uniformly sized adult Tetranychus cinnabarinus mites were placed on bean seedlings at the stage of first pair of true leaves (leaving one true leaf intact). After the adult mites stabilized, the population was counted. The test materials were then treated with the solution using the airbrush method, applying 1.5 mL per plant. A blank control was established.

[0121] After natural drying, the treated specimens are placed in an observation room where the temperature, humidity, and light levels can be adjusted as needed. After 72 hours, the number of live mites is counted and the mortality rate is calculated. The Bliss method is used for evaluation, which is one of the classic methods for evaluating the effects of mixed agents. Based on the concept of toxicity and combined effects proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated using the following formula: P = P m +Pn (1-P m )

[0122] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0123] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0124] The results are shown in Table 3.

[0125] Table 3 Synergistic effect of compound I and imidacloprid on adult Tetranychus cinnabarinus

[0126] Example 4 Determination of the synergistic effect of the composition containing compound I on Tetranychus cinnabarinus

[0127] Test subjects: Tetranychus cinnabarinus, adult mites, sensitive strain reared indoors.

[0128] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0129] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0130] Test Method: Activity against adult Tetranychus cinnabarinus mites was determined using a potted seedling spray method. First, 40-60 uniformly sized adult Tetranychus cinnabarinus mites were placed on bean seedlings at the stage of first pair of true leaves (leaving one true leaf intact). After the adult mites stabilized, the population was counted. The test materials were then treated with the solution using the airbrush method, applying 1.5 mL per plant. A blank control was established.

[0131] After natural drying, the treated specimens are placed in an observation room where the temperature, humidity, and light levels can be adjusted as needed. After 72 hours, the number of live mites is counted and the mortality rate is calculated. The Bliss method is used for evaluation, which is one of the classic methods for evaluating the effects of mixed agents. Based on the concept of toxicity and combined effects proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated using the following formula: P = P m +P n (1-P m )

[0132] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0133] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0134] The results are shown in Table 4.

[0135] Table 4 Synergistic effect of compound I and chlorantraniliprole on adult Tetranychus cinnabarinus

[0136] Example 5 Determination of the synergistic effect of the composition containing Compound I on the second-instar larvae of the diamondback moth

[0137] Test subjects: Second-instar larvae of the diamondback moth, a sensitive strain reared indoors.

[0138] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0139] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0140] Experimental method: Select fresh cabbage leaves grown in the greenhouse, use a hole punch to cut the cabbage leaves into round leaflets with a diameter of 3 cm, put them into the prepared solution and immerse them for 10 seconds. After natural drying in the shade, place them in a culture dish with a diameter of 9 cm with filter paper, and inoculate neatly with healthy test insects. Each treatment has 20-25 heads, and each treatment is repeated 4 times. A blank control is also set up.

[0141] Based on the concept of toxicity combination proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated by the following formula: P = P m +P n (1-P m )

[0142] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0143] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0144] The results are shown in Table 5.

[0145] Table 5 Synergistic effect of compound I mixed with chlorantraniliprole and others on Plutella xylostella larvae

[0146] Example 6 Determination of the synergistic effect of the composition containing Compound I on the second-instar larvae of the diamondback moth

[0147] Test subjects: Second-instar larvae of the diamondback moth, a sensitive strain reared indoors.

[0148] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0149] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0150] Experimental method: Select fresh cabbage leaves grown in the greenhouse, use a hole punch to cut the cabbage leaves into round leaflets with a diameter of 3 cm, put them into the prepared solution and immerse them for 10 seconds. After natural drying in the shade, place them in a culture dish with a diameter of 9 cm with filter paper, and inoculate neatly with healthy test insects. Each treatment has 20-25 heads, and each treatment is repeated 4 times. A blank control is also set up.

[0151] Based on the concept of toxicity combination proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated by the following formula: P = P m +P n (1-P m )

[0152] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0153] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0154] The results are shown in Table 6.

[0155] Table 6 Determination of the synergistic effect of compound I and avermectin on diamondback moth larvae

[0156] Example 7 Determination of the synergistic effect of the composition containing compound I on Tetranychus cinnabarinus

[0157] Test subjects: Tetranychus cinnabarinus, adult mites, sensitive strain reared indoors.

[0158] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0159] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0160] Test Method: Activity against adult Tetranychus cinnabarinus mites was determined using a potted seedling spray method. First, 40-60 uniformly sized adult Tetranychus cinnabarinus mites were placed on bean seedlings at the stage of first pair of true leaves (leaving one true leaf intact). After the adult mites stabilized, the population was counted. The test materials were then treated with the solution using the airbrush method, applying 1.5 mL per plant. A blank control was established.

[0161] After natural drying, the treated specimens are placed in an observation room where the temperature, humidity, and light levels can be adjusted as needed. After 72 hours, the number of live mites is counted and the mortality rate is calculated. The Bliss method is used for evaluation, which is one of the classic methods for evaluating the effects of mixed agents. Based on the concept of toxicity and combined effects proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated using the following formula: P = P m +P n (1-P m )

[0162] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0163] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0164] The results are shown in Table 7.

[0165] Table 7 Determination of the synergistic effect of compound I and avermectin on adult Tetranychus cinnabarinus

[0166] Example 8 Determination of the synergistic effect of the composition containing Compound I on western flower thrips larvae

[0167] Test subjects: Western flower thrips larvae, sensitive strain reared indoors.

[0168] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0169] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0170] Test Method: Add 0.5 mL of the prepared acetone solution to a glass tube (1 cm inner diameter, 10 cm length). Roll the tube repeatedly on a flat surface until the acetone solution evaporates completely. Immerse cabbage leaves in the corresponding concentration of solution for 15 seconds, let dry, and then place them in the glass tube. Catch 20-30 western flower thrips larvae in the tube. Each treatment is replicated four times. After treatment, observe in a constant temperature observation room. After 72 hours, count the number of live insects and calculate mortality.

[0171] The results are shown in Table 8.

[0172] Table 8 Synergistic effect of compound I and spinetoram mixed against western flower thrips larvae

[0173] Example 9 Determination of the synergistic effect of the composition containing Compound I on the second-instar larvae of Plutella xylostella

[0174] Test subjects: Second-instar larvae of the diamondback moth, a sensitive strain reared indoors.

[0175] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0176] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0177] Experimental method: Select fresh cabbage leaves grown in the greenhouse, use a hole punch to cut the cabbage leaves into round leaflets with a diameter of 3 cm, put them into the prepared solution and immerse them for 10 seconds. After natural drying in the shade, place them in a culture dish with a diameter of 9 cm with filter paper, and inoculate neatly with healthy test insects. Each treatment has 20-25 heads, and each treatment is repeated 4 times. A blank control is also set up.

[0178] Based on the concept of toxicity combination proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated by the following formula: P = P m +P n (1-P m )

[0179] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0180] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0181] The results are shown in Table 9.

[0182] Table 9 Synergistic effect of compound I mixed with cypermethrin and other two pesticides on diamondback moth larvae

[0183] Example 10 Determination of the synergistic effect of the composition containing Compound I on Tetranychus cinnabarinus

[0184] Test subjects: Tetranychus cinnabarinus, adult mites, sensitive strain reared indoors.

[0185] Test conditions: temperature: 24-26°C, relative humidity: 60%, light intensity: L:D = 14:10.

[0186] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance. The original drug was dissolved in acetone and then diluted with 0.1% Tween 80 water to a drug solution of a certain concentration according to the experimental design dosage.

[0187] Test Method: Activity against adult Tetranychus cinnabarinus mites was determined using a potted seedling spray method. First, 40-60 uniformly sized adult Tetranychus cinnabarinus mites were placed on bean seedlings at the stage of first pair of true leaves (leaving one true leaf intact). After the adult mites stabilized, the population was counted. The test materials were then treated with the solution using the airbrush method, applying 1.5 mL per plant. A blank control was established.

[0188] After natural drying, the treated specimens are placed in an observation room where the temperature, humidity, and light levels can be adjusted as needed. After 72 hours, the number of live mites is counted and the mortality rate is calculated. The Bliss method is used for evaluation, which is one of the classic methods for evaluating the effects of mixed agents. Based on the concept of toxicity and combined effects proposed by Bliss, the theoretical mortality rate P when insecticides and acaricides are mixed can be calculated using the following formula: P = P m +P n (1-P m )

[0189] P m is the target mortality rate (%) when the concentration of the first active component is m; P n The target mortality rate (%) when the second active ingredient is used at a concentration of n.

[0190] If the actual mortality rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical mortality rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0191] The results are shown in Table 10.

[0192] Table 10 Synergistic effect of compound I mixed with cypermethrin and other two agents on adult Tetranychus cinnabarinus

[0193] Example 11 Determination of the synergistic effect of a composition containing Compound I on Tetranychus cinnabarinus

[0194] Test subjects: Tetranychus cinnabarinus Boisduval, mite eggs, sensitive strain raised indoors, 1 day post-laying eggs.

[0195] Test conditions: Temperature: 24-28°C, relative humidity: 30-60%, light intensity: L:D = 12:12

[0196] Preparation of drug solution: According to different experimental requirements, the test samples (compositions of different ratios of the present invention and the original drug) were accurately weighed using an electronic analytical balance, and the samples were dissolved in acetone to prepare a mother solution, which was then diluted with 0.1% Tween-80 to a drug solution of a certain concentration according to the experimental design dosage.

[0197] Experimental Method: Kidney bean seedlings were taken during the first pair of true leaves, leaving one true leaf untouched. Ten adult female Tetranychus cinnabarinus mites of uniform development were placed on the leaves. After 24 hours, the female mites were removed and the leaves were sprayed using a spray device. A blank control was treated first, and the above procedure was repeated in ascending order of concentration, with three replicates per treatment. After treatment, all mite eggs were transferred to an observation room. After 7 days, all eggs in the blank control were allowed to hatch. The number of hatched eggs was counted and the hatching inhibition rate was calculated.

[0198] The evaluation adopts the Bliss method, which is one of the classic methods for evaluating the effects of mixtures. Based on the concept of independent combined effects proposed by Bliss, he believed that the theoretical inhibition rate P of mixed insecticides and acaricides can be calculated using the following formula: P = Pm + Pn (1-Pm)

[0199] Pm is the inhibition rate (%) of the target when the concentration of the first active component is m; Pn is the inhibition rate (%) of the target when the concentration of the second active component is n.

[0200] If the actual inhibition rate of the target after the two active components are mixed at a certain concentration is greater than the theoretical inhibition rate P, then it is determined that the two active components have a synergistic effect when mixed at the set concentration, otherwise it is an antagonistic effect.

[0201] The results are shown in Table 11.

[0202] Table 11 Synergistic effect of compound I mixed with 5 other agents including ethidium bromide on Tetranychus cinnabarinus eggs

[0203] As can be seen from the above table, the combination of compound I with ethidium bromide, spirocyclopentyl, propargyl, bifenazate and benzylfenamide has a significant synergistic effect on the eggs of Tetranychus cinnabarinus.

Claims

1. An insecticide and acaricide composition comprising active component A and active component B; wherein: The active component B is selected from one or more of biomimetic juvenile hormones, chitin biosynthesis inhibitors affecting CHS1, chitin biosynthesis inhibitor type 1, ecdysone receptor agonists, nicotinic acetylcholine receptor competitive modulators, ryanodine receptor modulators, nicotinic acetylcholine receptor allosteric modulators, glutamate-gated chloride channel allosteric modulators, sodium channel modulators, voltage-dependent sodium channel blockers, inhibitors affecting chitin synthase 1 mite growth, mitochondrial adenosine triphosphate synthase inhibitors, mitochondrial electron transport complex (III) inhibitors, mitochondrial electron transport complex (I) inhibitors, acetyl-CoA carboxylase inhibitors, mitochondrial electron transport complex (II) inhibitors, trifluoroethyl sulfide acaricides and other insecticides and acaricides; the active component A is selected from compound I or its stereoisomers, and the structure of compound I is as follows:

2. The insecticide and acaricide composition according to claim 1, characterized in that: The weight ratio of active component A to active component B is 99:1-1:99, preferably 80:1-1:80; And / or, the biomimetic juvenile hormone is selected from one or more of methoprene, methoprene, methoprene, fenoxycarb and pyriproxyfen; and / or, the chitin biosynthesis inhibitors affecting CHS1 are selected from one or more of diflubenzuron, fluazifop, lufenuron, fluazifop and flubendiamide; and / or, the chitin biosynthesis inhibitor type 1 is selected from buprofezin and / or cyromazine; and / or, the ecdysone receptor agonist is selected from one or more of chlorfenapyr, chlorfenapyr, methoxyfenapyr and tebufenozide; and / or the nicotinic acetylcholine receptor competitive modulator is selected from one or more of pyridapord, thiamethoxam, acetamiprid, dinotefuran, clothianidin, nitenpyram, thiacloprid, chlorothiazolin, flonicamid, pyrimidine, sulfonexamethasone, nicotine, sulfoxaflor, flupyrad, trifluanid, dichlorothiazolin and flufenac; And / or, the ryanodine receptor modulator is selected from one or more of flubendiamide, tetrachlorfenapyr, cyclobromofenapyr, tetrazolyl fenapyr, chlorantraniliprole, cyantraniliprole and chlorfluanid; and / or, the nicotinic acetylcholine receptor allosteric modulators are selected from spinosad and / or spinosad; and / or, the glutamate-gated chloride channel allosteric modulators are selected from one or more of avermectin, avermectin benzoate, lepidomectin and mibemectin; and / or, the sodium channel modulator is selected from cypermethrin, lambda-cyhalothrin, fenpropathrin, fenvalerate, flucythrinate, flumethrin, beta-cyfluthrin, cyfluthrin, bifenthrin, deltamethrin, acrinathrin, alph a-cypermethrin), bifenthrin, cyhalothrin, permethrin, fluvalinate, allethrin, bioallethrin, cycloprothrin, gamma-cyhalothrin, theta-cypermethrin, zeta-cypermethrin, cyphenothiazine, hrin), empenthrin, esfenvalerate, imiprothrin, meperfluthrin, metofluthrin, dimefluthrin, prallethrin, phenothrin, resmethrin, bioresmethrin, cismethrin, tefluthrin, tetramethrin methrin), tetramethylfluthrin, tralomethrin, beta-cypermethrin, ethofenprox, transfluthrin, esdépalléthrine, barthrin, bioethanomethrin, brofenvalerate, brofluthrinate, bromethrin, butethrin,Chlorempenthrin, cyclethrin, cyhalothrin, lambda-cyhalothrin, dimethrin, d-fanshiluquebingjuzhi, fenfluthrin, fenpirithrin, esfenvalerate, furamethrin, imiprothrin, japothrins, kadethrin, methotrexate, pentmethrin, biopermethrin, and fenfluthrin one or more of: proparthrin, resmethrin, terallethrin, tralocythrin, valerate, flufenprox, halfenprox, sulfoxime, thiofluoximate, flumethrin, furethrin, heptafluthrin, momfluorothrin, transpermethrin, profluthrin, pyresmethrin, protrifenbute, silafluofen, DDT, and methoxychlor; and / or, the voltage-dependent sodium channel blockers are selected from indoxacarb and / or metaflumizone; and / or, the inhibitors affecting the growth of chitin synthase 1 mites are selected from one or more of clofentezine, fluazifop, hexythiazox and etoxazole; and / or, the mitochondrial ATP synthase inhibitors are selected from one or more of diafenthiuron, azoxatin, cyhexatin, fenbutatin, propargite and fenbutafen; And / or, the mitochondrial electron transport complex (III) inhibitor is selected from one or more of hydrazone, acequinoxaline, pyrimidifen and bifenazate; and / or, the mitochondrial electron transport complex (I) inhibitors are selected from one or more of fenazaquin, fenpyrad, pyridabenz, pyrimidifen, tebufenpyrad, tolfenpyrad and rotenone; and / or, the acetyl-CoA carboxylase inhibitors are selected from one or more of spirodiclofen, spiromesifen, ethyl methoxyfen and spirotetramat; and / or, the mitochondrial electron transport complex (II) inhibitors are selected from one or more of cypermethrin, ethoxyfen, cyflumetofen and pyrazoanilide; and / or, the trifluoroethyl sulfide acaricide is selected from one or more of bentioflumin, bisulflufen, sulfiflumin and flupentiofenox; And / or, other insecticides and acaricides are selected from one or more of azadirachtin, cryolite, boric acid, sulfuryl fluoride, sulfanilamide, sodium sulfamethoxam, amitraz and veratridine.

3. The insecticide and acaricide composition according to claim 2, characterized in that: The active component B is selected from one or more of pyriproxyfen, lufenuron, buprofen and methoxyfenozide.

4. The insecticide and acaricide composition according to claim 3, characterized in that: The active component A is selected from compound I or its stereoisomers, and the active component B is selected from pyriproxyfen; the weight ratio of the two active components is 20:1-1:50; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from lufenuron; the weight ratio of the two active components is 20:1-1:50; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from buprofezin; the weight ratio of the two active components is 20:1-1:50; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from methoxyfenozide; the weight ratio of the two active components is 20:1-1:

50.

5. The insecticide and acaricide composition according to claim 2, characterized in that: The active component B is selected from one or more of imidacloprid, sulfoxaflor and trifluanid.

6. The insecticide and acaricide composition according to claim 5, characterized in that: The active component A is selected from compound I or its stereoisomers, and the active component B is selected from imidacloprid; the weight ratio of the two active components is 30:1-1:30; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from sulfoxaflor; the weight ratio of the two active components is 5:1-1:40; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from trifluridine; the weight ratio of the two active components is 20:1-1:

50.

7. The insecticide and acaricide composition according to claim 2, characterized in that: The active component B is selected from chlorantraniliprole and / or cyantraniliprole.

8. The insecticide and acaricide composition according to claim 7, characterized in that: The active component A is compound I, and the active component B is selected from chlorantraniliprole; the weight ratio of the two active components is 10:1-1:80; Alternatively, the active component A is compound I, and the active component B is selected from cyantraniliprole; the weight ratio of the two active components is 10:1-1:

10.

9. The insecticide and acaricide composition according to claim 2, characterized in that: The active component B is selected from spinetoram and / or avermectin.

10. The insecticide and acaricide composition according to claim 9, characterized in that: The active component A is selected from compound I or its stereoisomers, and the active component B is selected from spinetoram; the weight ratio of the two active components is 2:1-1:10; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from avermectin; the weight ratio of the two active components is 80:1-1:

11.

11. The insecticide and acaricide composition according to claim 2, characterized in that: The active component B is selected from cypermethrin and / or indoxacarb.

12. The insecticide and acaricide composition according to claim 11, characterized in that: The active component A is selected from compound I or its stereoisomers, and the active component B is selected from cypermethrin, and the weight ratio of the two active components is 5:1-1:80; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from indoxacarb; the weight ratio of the two active components is 10:1-1:

40.

13. The insecticide and acaricide composition according to claim 2, characterized in that: The active component B is selected from one or more of etoxazole, veratridine, pyridabenz, propargyl, bifenazate, spirocyclopentyl, ethoxaclonil and benzylfenac.

14. The insecticide and acaricide composition according to claim 13, characterized in that: The active component A is selected from compound I or its stereoisomers, and the active component B is selected from etoxazole, and the weight ratio of the two active components is 30:1-1:30; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from veratridine; the weight ratio of the two active components is 30:1-1:30; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from pyridabenz; the weight ratio of the two active components is 30:1-1:30; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from diafenthiuron or propargite; the weight ratio of the two active components is 30:1-1:80; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from bifenazate; the weight ratio of the two active components is 30:1-1:80; Or, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from spirodiclofen or spiromesiclofen; the weight ratio of the two active components is 4:1-1:25; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from ethidium bromide; the weight ratio of the two active components is 20:1-1:20; Alternatively, the active component A is selected from compound I or its stereoisomers, and the active component B is selected from benzyltetramine; the weight ratio of the two active components is 20:1-1:

40.

15. The insecticide and acaricide composition according to any one of claims 1 to 14, characterized in that: The composition is mixed with a carrier and any auxiliary agent to prepare a preparation containing the composition, wherein the cumulative content of the active component of the composition in the preparation is between 0.5wt% and 95wt%; preferably, the cumulative content of the active component in the preparation is between 1wt% and 85wt%.

16. Use of the insecticide and acaricide composition according to any one of claims 1 to 15 in the preparation of an insecticide and acaricide for controlling agricultural pests or urban pests.

17. The use according to claim 16, characterized in that The prepared insecticide and acaricide is applied to the pests to be controlled or the medium where they grow in an effective dose.

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