High-throughput automated chemical synthesis workstation

Abstract

A high-throughput automated chemical synthesis workstation, relating to the technical field of chemical synthesis. The workstation comprises a base. The base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank, wherein the negative pressure suction filter and the magnetic stirring reactor can be replaced with other testing instruments; a screw is lap-jointed on the cover plate; a moving device is also mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly are mounted on the moving device; and pipetting is performed by the pipetting assembly, the gripper assembly drives the cover plate to move to the high-throughput chemical reaction module for sealing, and after tightening is performed by the tightening assembly, the gripper assembly drives the sealed module to move to the reactor, thereby achieving real-time observation during remote operation.

Description

A high-throughput automated chemical synthesis workstation

[0001] Cross-references to related applications

[0002] This application claims priority to Chinese Patent Application No. 202410486077.8, filed on April 22, 2024, entitled "A High-Throughput Automated Chemical Synthesis Workstation", the entire contents of which are incorporated herein by reference. Technical Field

[0003] This application relates to the field of chemical synthesis technology, and in particular to a high-throughput automated chemical synthesis workstation. Background Technology

[0004] High-throughput chemistry is a chemical research method that utilizes automated equipment and high-throughput technology to rapidly and efficiently perform large-scale chemical reactions and compound synthesis. The goal of high-throughput chemistry is to accelerate the discovery and optimization of new compounds, as well as drug screening and materials development, by simultaneously processing multiple reaction conditions and compound samples. While existing high-throughput automated workstations are well-established in the biological and medical fields, chemical synthesis itself is labor-intensive, complex, and hazardous, making direct application in high-throughput chemistry impossible. Achieving high-throughput automated chemical synthesis remains a significant challenge in the pharmaceutical industry and university laboratories both domestically and internationally. To address the limitations of traditional pipetting methods, high-throughput pipetting devices have emerged. These devices integrate liquid handling, transfer, and dispensing functions, significantly improving experimental efficiency and reducing human error. In addition to automated liquid handling systems, high-throughput pipetting devices also require high-precision sensors and control systems. These sensors monitor liquid position, flow rate, and concentration in real time, feeding this information back to the control system to ensure accurate liquid dispensing.

[0005] Chinese utility model patent CN211896907U discloses a multifunctional liquid workstation, including a support frame, a base plate, a pipette tip storage box area, an oscillation module, a consumable plate placement area, a centrifuge, a reagent storage area, a temperature control module, and a nucleic acid extraction module. The functional modules of this liquid workstation can be combined and separated, making it suitable for different scenarios and costs. It achieves high-throughput micro-volume nucleic acid extraction and can also be used as a general-purpose liquid workstation for automated operations in pipetting, separation, and other biological experiments. However, it is not suitable for experimental environments that require heating to high temperatures and closed reaction systems. It cannot effectively protect the mixed liquid in the system from contamination or volatilization during the reaction process after pipetting, and the combined and replaceable modules are not easy to replace.

[0006] Summary of the Invention

[0007] To better seal the high-throughput chemical reaction system and protect the mixture during the reaction process, to facilitate the replacement of different functions, and to improve the automation level of high-throughput chemistry technology, this application discloses a high-throughput automated chemical synthesis workstation, the specific technical solution of which is as follows:

[0008] A high-throughput automated chemical synthesis workstation includes a base, a moving device mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly mounted on the moving device. Multiple first mounting plates are detachably mounted on the base. Each of the first mounting plates is respectively equipped with a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank. The high-throughput chemical reaction module has threaded holes, and screws are attached to the cover plate. Through this technical solution, the gripper assembly can move the cover plate onto the high-throughput chemical reaction module, and the tightening assembly tightens the screws, ensuring tight contact between the cover plate and the high-throughput chemical reaction module, achieving a sealing effect and ensuring the reaction system within the reaction module is sealed. The detachable first and second mounting plates also facilitate replacement.

[0009] Optionally, a monitoring module is installed on the base to monitor the entire working process and can also be observed in real time during remote operation.

[0010] Optionally, the first mounting plate is a square plate, and each of the four bottom corners of the first mounting plate is fixedly equipped with a pad. The pads support the first mounting plate and are height-adjustable, allowing them to be adjusted to a horizontal position. Before use, the plate must be leveled. Both sides of the first mounting plate are equipped with handles and pull rings for easy movement and handling.

[0011] Optionally, the base is equipped with multiple second mounting plates, on which a negative pressure filter and a magnetically stirred reactor can be detachably mounted. This technical solution enables the stirring and heating of the mixture within the high-throughput chemical reaction module, and ultimately allows for collection after filtration, ensuring the quality of the final product. Furthermore, when the reaction module is moved onto the magnetically stirred reactor, the cover prevents leakage of the mixture from the reaction module, and the reaction module remains sealed during heating to prevent evaporation of the mixture.

[0012] Optionally, the second mounting plate includes a second metal plate with a second positioning hole. A positioning pin is provided on the base, and the positioning pin engages within the second positioning hole. Multiple limiting blocks are provided on the second metal plate, configured to fix the negative pressure filter or magnetic stirring reactor onto the second metal plate. This technical solution allows the second mounting plate to be accurately placed on the corresponding position on the base, facilitating positioning and ensuring the accurate operation of the entire device.

[0013] Optionally, a second magnet is fixedly mounted on the second metal plate, and an auxiliary magnet is mounted on the base. The second magnet and the auxiliary magnet on the base cooperate to fix the second metal plate. Through this technical solution, using the second magnet allows for quicker placement and removal, and also enables secure fixation.

[0014] Optionally, the first mounting plate includes a first metal plate, on which a first snap-fit ​​plate is detachably mounted. The high-throughput chemical reaction module, pipette tip box, cover plate, and liquid storage tank are snapped onto the first snap-fit ​​plate. The first metal plate has a first positioning hole, and the base has a positioning pin that engages within the first positioning hole. The first snap-fit ​​plate, which holds the cover plate, has a support rod for raising the cover plate to a height greater than the length of the screw. This technical solution allows the first mounting plate to be accurately placed on the base, facilitating precise positioning during liquid transfer and ensuring smooth machine operation.

[0015] Optionally, a first magnet is fixedly mounted on the first metal plate, and an auxiliary magnet is mounted on the base. The first magnet and the auxiliary magnet on the base cooperate to fix the first metal plate. This technical solution allows the first mounting plate to be fixed to the base and makes it easier to remove and fix.

[0016] Optionally, the moving device includes an X-axis moving component and a Y-axis moving component, and the tightening component, the gripper component, and the pipetting component all include a Z-axis moving component and are driven to move up and down respectively.

[0017] Optionally, the pipetting assembly includes a pipette tip, and a Z-axis moving assembly drives the pipette tip to move up and down to perform pipetting.

[0018] Optionally, the gripper assembly includes a gripping electric cylinder, and the Z-axis moving assembly drives the gripping electric cylinder to move up and down. A first gripping rod and a second gripping rod are slidably mounted on the lower end of the gripping electric cylinder. A first gripping head is fixedly mounted on the lower side of the first gripping rod, and a second gripping head is fixedly mounted on the lower side of the second gripping rod.

[0019] Optionally, the tightening assembly includes a screw gun, a Z-axis moving assembly that drives the screw gun to move up and down, and a tightening head mounted on the lower end of the screw gun. The tightening head is used to tighten the screws so that the cover plate seals the high-throughput chemical reaction module.

[0020] Optionally, a first handle is fixedly installed at one end of the first metal plate, and the entire first mounting plate can be easily removed by holding the first handle.

[0021] Optionally, five first mounting plates are provided, four nozzle boxes are provided, and they are respectively placed on the first snap-fit ​​plates of the two first mounting plates; four liquid storage tanks are provided, and they are respectively placed on the first snap-fit ​​plates of the two first mounting plates.

[0022] Optionally, the moving device includes a support base, on which an X-axis slide rail and an X-axis electric cylinder are fixedly mounted. An X-axis slider is slidably mounted on the X-axis slide rail, and the X-axis electric cylinder is configured to drive the X-axis slider to slide on the X-axis slide rail.

[0023] Optionally, a Y-axis slide rail and a Y-axis electric cylinder are fixedly mounted on the X-axis slider, and a Y-axis slider is slidably mounted on the Y-axis slide rail. The Y-axis electric cylinder drives the Y-axis slider to slide on the Y-axis slide rail. The tightening assembly, the gripper assembly, and the pipetting assembly are all mounted on the Y-axis slider.

[0024] Optionally, the tightening assembly includes a tightening electric cylinder and a tightening slide rail. Both the tightening electric cylinder and the tightening slide rail are mounted on the Y-axis slider. A tightening slider is slidably mounted on the tightening slide rail. The tightening electric cylinder drives the tightening slider to slide on the tightening slide rail. A screw gun is fixedly mounted on the tightening slider, and a tightening gun head is provided on the screw gun.

[0025] Optionally, the pipetting assembly includes a pipetting slide rail and a pipetting cylinder. The pipetting slide rail and the pipetting cylinder are mounted on a Y-axis slider. A pipetting slider is slidably mounted on the pipetting slide rail. The pipetting cylinder drives the pipetting slider to slide on the pipetting slide rail. A pipetting tip is fixedly mounted on the pipetting slider.

[0026] Optionally, the pipetting assembly employs an eight-channel pipetting configuration.

[0027] Optionally, the gripper assembly includes a movable electric cylinder and a movable slide rail, which are mounted on a Y-axis slider. A movable block is slidably mounted on the movable slide rail, and the movable electric cylinder drives the movable block to slide on the movable slide rail.

[0028] The advantages of this application compared to the prior art are:

[0029] (1) The technical solution of this application ensures that high-throughput chemical synthesis experiments, from liquid transfer, sealing of reaction system, reaction start-up, gradient dilution and filtration, can be completed in one workstation.

[0030] (2) Through the technical solution of this application, the gripper assembly can move the cover plate to the high-throughput chemical reaction module and tighten the screws through the tightening assembly, so that the cover plate and the high-throughput chemical reaction module are in close contact, achieving a sealing effect, ensuring that the reaction inside the high-throughput chemical reaction module is not contaminated by impurities in the air, ensuring that the reaction system is sealed during heating to prevent the mixture from evaporating, and the detachable first mounting plate and second mounting plate also make it easier to replace different functional modules.

[0031] (3) Through the technical solution of this application, the mixture in the high-throughput chemical reaction module can be stirred and heated, and can be collected after filtration to ensure the quality of the final product. At the same time, when the high-throughput chemical reaction module is moved to the magnetic stirring reactor, the cover plate can prevent the mixture in the high-throughput chemical reaction module from leaking out. When heated, the reaction module is in a closed state to prevent the mixture from evaporating.

[0032] (4) The technical solution of this application can accurately place the second mounting plate on the corresponding position on the base, which is convenient for positioning and ensures the accurate operation of the whole device.

[0033] (5) Through the technical solution of this application, the second magnet can be used to replace and place the object more quickly, and can also be fixed.

[0034] (6) The technical solution of this application enables the first mounting plate to be accurately placed on the base, which facilitates accurate positioning during liquid transfer and ensures smooth operation of the machine.

[0035] (7) The technical solution of this application enables the first mounting plate to be fixed on the base and to be more convenient to remove and fix. Attached Figure Description

[0036] Figure 1 is a schematic diagram of the overall structure of an embodiment of this application.

[0037] Figure 2 is a schematic diagram of the first mounting plate structure according to an embodiment of this application.

[0038] Figure 3 is a schematic diagram of the second mounting plate structure according to an embodiment of this application.

[0039] Figure 4 is a schematic diagram of the cover plate and screws in an embodiment of this application.

[0040] Figure 5 is a schematic diagram of the fastening assembly and gripper assembly structure according to an embodiment of this application.

[0041] Figure 6 is a schematic diagram of the gripper assembly according to an embodiment of this application.

[0042] Reference numerals: 1-Base; 2-Moving device; 3-Tightening assembly; 4-Gripper assembly; 5-Pipette assembly; 6-First mounting plate; 7-Second mounting plate; 8-Negative pressure filter; 9-Magnetic stirring reactor; 10-High-throughput chemical reaction module; 11-Pipe head box; 12-Cover plate; 13-Screw; 14-Reservoir; 15-Monitoring module; 16-Support rod; 101-Mounting plate; 102-Foot pad; 103-Hand buckle; 104-Pull ring; 201-Support base; 202-X-axis slide rail; 203-X-axis electric cylinder; 204-X-axis slider; 205-Y-axis slide rail; 206-Y-axis slider; 207-Y-axis electric cylinder; 301-Tightening electric cylinder; 302-Tightening slider Rail; 303-Tightening slider; 304-Screw gun; 305-Tightening gun head; 401-Moving electric cylinder; 402-Moving slide rail; 403-Moving block; 404-Clamping electric cylinder; 405-First clamping rod; 406-Second clamping rod; 407-Second clamping head; 408-First clamping head; 501-Pipette slide rail; 502-Pipette electric cylinder; 503-Pipette slider; 504-Pipette tip; 601-First metal plate; 602-First handle; 603-First snap-fit ​​plate; 604-First magnet; 605-First positioning hole; 701-Second metal plate; 702-Second handle; 703-Limiting block; 704-Second magnet; 705-Second positioning hole. Detailed Implementation

[0043] The technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this application.

[0044] As shown in Figures 1-6, a high-throughput automated chemical synthesis workstation includes a base 1. The base 1 is detachably equipped with multiple first mounting plates 6 and multiple second mounting plates 7. The first mounting plates 6 and the second mounting plates 7 are equipped with a negative pressure filter 8, a magnetic stirring reactor 9, a high-throughput chemical reaction module 10, a pipette tip box 11, a cover plate 12, and a liquid storage tank 14. The negative pressure filter 8 and the magnetic stirring reactor 9 can be replaced with other detection instruments, such as photochemical reactors and electrochemical reactors of the same size. The cover plate 12 is fitted with screws 13. The base 1 is also equipped with a moving device 2, which is equipped with a tightening assembly 3, a gripper assembly 4, and a pipetting assembly 5. Liquid is pipetted through the pipetting assembly 5, and the cover plate 12 is moved onto the high-throughput chemical reaction module 10 for sealing through the gripper assembly 4. The tightening assembly 3 is used for fastening. The base 1 is equipped with a monitoring module 15, which monitors the entire working process and can also be observed in real time during remote operation. The technical solution of this embodiment ensures that high-throughput chemical synthesis experiments, from liquid transfer, sealing of the reaction system, reaction start-up, gradient dilution and filtration, can be completed in one workstation. After integration, the solution can be used to conduct experiments more completely and achieve a high degree of automation.

[0045] As shown in Figure 1, in this embodiment, the base 1 includes a mounting plate 101, which is a square plate. Each of the four bottom corners of the mounting plate 101 is fixedly equipped with a pad 102. The pad 102 supports the mounting plate 101 and is height-adjustable. The pad 102 can be adjusted to a horizontal state. Before use, it must be leveled. Both sides of the mounting plate 101 are provided with a handle 103 and a pull ring 104 for easy movement and handling.

[0046] As shown in Figures 2 and 4, in this embodiment, five first mounting plates 6 are provided. Each first mounting plate 6 includes a first metal plate 601 with a first positioning hole 605. A positioning pin is provided on the upper surface of the mounting plate 601, and the positioning pin is fitted into the first positioning hole 605 for positioning. Two first magnets 604 are also fixedly mounted on the first metal plate 601. An auxiliary magnet is provided on the mounting plate 101, and the first magnets 604 can be attracted to the auxiliary magnets on the mounting plate 101 for fixation. A first snap-fit ​​plate 603 is detachably mounted on the first metal plate 601, and in this embodiment, it is connected by bolts. A threaded hole is provided on the first mounting plate 603, and a bolt passes through the first snap-fit ​​plate 603 and is fastened to the first metal plate 601, thereby fixing the first snap-fit ​​plate 603 and the first metal plate 601. A first handle 602 is fixedly installed at one end of the first metal plate 601, allowing for easy removal of the entire first mounting plate 6 by lifting the first handle 602. In this embodiment, four first snap-fit ​​plates 603 are respectively placed on the two first mounting plates 6 of the nozzle box 11, and four first snap-fit ​​plates 603 are respectively placed on the two first mounting plates 6 of the liquid storage tank 14. The high-throughput chemical reaction module 10 and the cover plate 12 are placed together on the first snap-fit ​​plate 603 of the same first mounting plate 6. A support rod 16 is provided on the first snap-fit ​​plate 603 that snaps onto the cover plate 12, which is used to raise the height of the cover plate 12, and the height is greater than the length of the screw 13.

[0047] As shown in Figures 1 and 3, two second mounting plates 7 are provided in this embodiment. Different instruments, such as negative pressure filters 8 and magnetic stirring reactors 9, can be placed on the second mounting plates 7 according to different reaction requirements. Two negative pressure filters 8 or two magnetic stirring reactors 9 can be placed simultaneously. A magnetic stirring reactor 9 is a laboratory instrument that uses a magnetic field to force convection of liquids to achieve mixing. Its basic principle is to utilize the properties of like poles repelling and unlike poles attracting in magnetic fields. By continuously changing the polarity of the two ends of the base, the magnetic stir bar is driven to rotate, thereby rotating the sample and making the sample uniformly mixed. Magnetic stirring reactors are mainly used for stirring or simultaneously heating and stirring low-viscosity liquids or solid-liquid mixtures, which can accelerate the reaction rate or evaporation rate and shorten the time. It is often used in pharmaceutical equipment for processes such as liquid drug preparation, dissolution, homogenization, mixing, and reaction. Its advantages include no pollution, precise temperature control, and adjustable rotation speed, which can improve the efficiency and quality of drug preparation and ensure drug safety and no pollution.

[0048] The negative pressure filter press is mainly used for the separation of liquid and solid mixtures (such as suspensions). It utilizes negative pressure (vacuum) to extract liquid from the mixture, leaving solid particles on the filter medium, thus achieving solid-liquid separation. Its working principle is relatively simple yet highly efficient. The equipment contains a sealed filter chamber with filter plates covered by filter media (such as filter paper or filter cloth). The mixture is placed on the filter plates, and then a vacuum pump is activated to create negative pressure within the filter chamber. This negative pressure draws the liquid through the filter medium, while solid particles remain on the medium. After a period of filtration, most of the liquid is removed, leaving solid residue.

[0049] In this embodiment, a negative pressure filter 8 and a magnetic stirring reactor 9 are respectively mounted on two second mounting plates 7. The second mounting plate 7 includes a second metal plate 701, which has two second positioning holes 705. A positioning pin is provided on the mounting plate 101, and the positioning pin passes through the second positioning holes 705 for positioning. Two second magnets 704 are fixedly mounted on the lower end of the second metal plate 701. Since the mounting plate 101 is provided with auxiliary magnets, the second magnets 704 will be attracted to the mounting plate 101 for fixation. Multiple limiting blocks 703 are detachably mounted on the second metal plate 701, specifically four. The limiting blocks 703 are fixed on the second metal plate 701 by bolts. Multiple threaded holes are provided on the second metal plate 701 at different positions. The limiting blocks 703 can be adjusted according to the instrument to be fixed, fixing the instrument at different positions on the second metal plate 701. The second metal plate 701 is fixedly mounted on the second metal plate 701, and the entire second mounting plate 7 can be easily removed by carrying the second metal plate 701.

[0050] As shown in Figure 1, in this embodiment, the moving device 2 includes a support base 201, which is fixedly mounted on the mounting plate 101. An X-axis slide rail 202 and an X-axis electric cylinder 203 are fixedly mounted on the support base 201. An X-axis slider 204 is slidably mounted on the X-axis slide rail 202. The X-axis electric cylinder 203 is configured to drive the X-axis slider 204 to slide on the X-axis slide rail 202. A Y-axis slide rail 205 and a Y-axis electric cylinder 207 are fixedly mounted on the X-axis slider 204. A Y-axis slider 206 is slidably mounted on the Y-axis slide rail 205. The Y-axis electric cylinder 207 drives the Y-axis slider 206 to slide on the Y-axis slide rail 205. The tightening assembly 3, the gripper assembly 4, and the pipetting assembly 5 are all mounted on the Y-axis slider 206. Each of the tightening assembly 3, the gripper assembly 4, and the pipetting assembly 5 includes a Z-axis moving component, which can respectively drive the tightening assembly 3, the gripper assembly 4, and the pipetting assembly 5 to move along the Z-axis.

[0051] As shown in Figures 1 and 5, in this embodiment, the tightening assembly 3 includes a tightening electric cylinder 301 and a tightening slide rail 302. Both the tightening electric cylinder 301 and the tightening slide rail 302 are mounted on the Y-axis slider 206. A tightening slider 303 is slidably mounted on the tightening slide rail 302. The tightening electric cylinder 301 drives the tightening slider 303 to slide on the tightening slide rail 302. A screwdriver 304 is fixedly mounted on the tightening slider 303, and the screwdriver 304 is provided with a tightening head 305, controlled by torque. The screws 13 on the cover plate 12 are unscrewed and locked in a predetermined sequence. The pipetting assembly 5 includes a pipetting slide rail 501 and a pipetting cylinder 502. The pipetting slide rail 501 and the pipetting cylinder 502 are mounted on the Y-axis slider 206. A pipetting slider 503 is slidably mounted on the pipetting slide rail 501. The pipetting cylinder 502 drives the pipetting slider 503 to slide on the pipetting slide rail 501. A pipetting tip 504 is fixedly mounted on the pipetting slider 503. The pipetting assembly 5 adopts an eight-channel pipetting configuration.

[0052] As shown in Figures 1, 5, and 6, in this embodiment, the gripper assembly 4 includes a movable electric cylinder 401 and a movable slide rail 402. The movable electric cylinder 401 and the movable slide rail 402 are mounted on the Y-axis slider 206. A movable block 403 is slidably mounted on the movable slide rail 402. The movable electric cylinder 401 drives the movable block 403 to slide on the movable slide rail 402. A clamping electric cylinder 404 is fixedly mounted on the movable block 403. A first clamping rod 405 and a second clamping rod 406 are slidably mounted on the lower end of the clamping electric cylinder 404. The clamping electric cylinder 404 drives the first clamping rod 405 and the second clamping rod 406 to move away from or towards each other to achieve clamping operation. A first clamping head 408 is fixedly mounted on the first clamping rod 405, and a second clamping head 407 is fixedly mounted on the second clamping rod 406 to enhance the stability of clamping.

[0053] The working principle of a high-throughput automated chemical synthesis workstation according to an embodiment of this application is as follows: In use, firstly, place the first mounting plate 6 and the second mounting plate 7 in their corresponding positions. Then, fix the negative pressure filter 8 or the magnetic stirring reactor 9 onto the second mounting plate 7 as needed. Place the high-throughput chemical reaction module 10, pipette tip box 11, cover plate 12, and storage tank 14 onto the first mounting plate 6. Start the moving device 2, which drives the pipetting assembly 5 to align with the lower side of the pipette tip box 11 via the X and Y axes. Start the pipetting cylinder 502 to move the pipette tip 504 downwards, picking up the tip. Then, start the moving device 2 again, which drives the pipetting assembly 5 via the X and Y axes. The device moves to the top of the storage tank 14 to draw liquid. The moving device 2 is then activated again, using the X and Y axes to move the pipetting assembly 5 above the high-throughput chemical reaction module 10. The pipetting assembly 5 then moves above the tip box 11 to change the tip, continuing to transfer different liquids from the storage tank 14 to the high-throughput chemical reaction module 10. The moving device 2 then moves the gripper assembly 4 above the cover plate 12. The clamping cylinder 404 is activated, causing the first clamping rod 405 and the second clamping rod 406 to move closer together. The cover plate 12 is clamped by the second clamping head 407 and the first clamping head 408, and the module moves to the high-throughput chemical reaction module 10. Cover the reaction module 10 from above, and move the tightening assembly 3 above the high-throughput chemical reaction module 10 again using the moving device 2. Align the tightening gun head 305 with the screw 13 on the cover plate 12. The reaction module 10 has threaded holes; screw the screw 13 into them to fix the cover plate 12 and the reaction module 10 together, thus achieving a seal. Use the gripper assembly 4 to clamp the entire high-throughput chemical reaction module 10 along with the cover plate 12 and move it to the magnetic stirring reactor 9 for stirring and heating. After stirring and heating are completed, use the gripper assembly 4 to return the high-throughput chemical reaction module 10 to its original position and loosen the tightening assembly 3. Unscrew 13, and use the gripper assembly 4 to return the cover plate 12 to its original position. Then, use the pipette tip 504 to further mix the liquid in the high-throughput chemical reaction module 10. Replace the pipette tip and add the diluent from the storage tank 14 to the high-throughput chemical reaction module 10 for gradient dilution. Repeat this process until the required concentration is reached. Then, use the pipette assembly 5 to transfer the liquid in the high-throughput chemical reaction module 10 to the negative pressure filter 8 for filtration. The liquid is then extracted using the negative pressure filter 8 to complete the experiment. The entire process is recorded by the monitoring module 15 and can also be remotely operated via the real-time display of the monitoring module 15.

[0054] The present application has been further described above with reference to specific embodiments. However, it should be understood that the specific descriptions herein should not be construed as limiting the substance and scope of the present application. Various modifications made by those skilled in the art to the above embodiments after reading this specification are all within the scope of protection of the present application. Industrial applicability

[0055] This application provides a high-throughput automated chemical synthesis workstation that better seals the high-throughput chemical reaction system to protect the mixture during the reaction process, makes it easier to change different functions, and improves the automation level of high-throughput chemical technology.

[0056] Furthermore, it is understood that the high-throughput automated chemical synthesis workstation of this application is reproducible and can be widely applied in the field of chemical synthesis.

Claims

1. A high-throughput automated chemical synthesis workstation, characterized in that, Includes a base (1), on which a moving device (2) is mounted, and on which a tightening assembly (3), a gripper assembly (4), and a pipetting assembly (5) are mounted. Multiple first mounting plates (6) are detachably mounted on the base (1). On the multiple first mounting plates (6) are respectively mounted a high-throughput chemical reaction module (10), a pipette tip box (11), a cover plate (12), and a liquid storage tank (14). The high-throughput chemical reaction module (10) is provided with threaded holes, and screws (13) are attached to the cover plate (12).

2. The high-throughput automated chemical synthesis workstation according to claim 1, characterized in that, The base (1) is equipped with a plurality of second mounting plates (7), on which a negative pressure filter (8) and a magnetic stirring reactor (9) are detachably mounted.

3. The high-throughput automated chemical synthesis workstation according to claim 2, characterized in that, The second mounting plate (7) includes a second metal plate (701), on which a second positioning hole (705) is provided. The base (1) is provided with a positioning pin, which is engaged in the second positioning hole (705). The second metal plate (701) is provided with a plurality of limiting blocks (703), which are configured to fix the negative pressure filter (8) or the magnetic stirring reactor (9) on the second metal plate (701).

4. The high-throughput automated chemical synthesis workstation according to claim 3, characterized in that, A second magnet (704) is fixedly mounted on the second metal plate (701), and an auxiliary magnet is provided on the base (1). The second magnet (704) cooperates with the auxiliary magnet on the base (1) to fix the second metal plate (701).

5. The high-throughput automated chemical synthesis workstation according to claim 1, characterized in that, The first mounting plate (6) includes a first metal plate (601), and the first metal plate (601) is detachably mounted with a first snap-fit ​​plate (603). The reaction module (10), the nozzle box (11), the cover plate (12) and the liquid storage tank (14) are snapped onto the first snap-fit ​​plate (603). The first metal plate (601) is provided with a first positioning hole (605). The base (1) is provided with a positioning pin, which is engaged in the first positioning hole (605). The first snap-fit ​​plate (603) that is engaged with the cover plate (12) is provided with a support rod (16) for raising the height of the cover plate (12), which is greater than the length of the screw (13).

6. The high-throughput automated chemical synthesis workstation according to claim 5, characterized in that, A first magnet (604) is fixedly mounted on the first metal plate (601), and an auxiliary magnet is provided on the base (1). The first magnet (604) and the auxiliary magnet on the base (1) cooperate to fix the first metal plate (601).

7. The high-throughput automated chemical synthesis workstation according to claim 1, characterized in that, The moving device (2) includes an X-axis moving component and a Y-axis moving component. The tightening component (3), the gripper component (4), and the pipetting component (5) all include a Z-axis moving component and are driven to move up and down respectively.

8. The high-throughput automated chemical synthesis workstation according to claim 7, characterized in that, The pipetting assembly (5) includes a pipetting tip (504), and the Z-axis moving assembly drives the pipetting tip (504) to move up and down to perform pipetting.

9. The high-throughput automated chemical synthesis workstation according to claim 7, characterized in that, The gripper assembly (4) includes a gripping electric cylinder (404). The Z-axis moving assembly drives the gripping electric cylinder (404) to move up and down. A first gripping rod (405) and a second gripping rod (406) are slidably mounted on the lower end of the gripping electric cylinder (404). A first gripping head (408) is fixedly mounted on the lower side of the first gripping rod (405), and a second gripping head (407) is fixedly mounted on the lower side of the second gripping rod (406).

10. The high-throughput automated chemical synthesis workstation according to claim 7, characterized in that, The tightening assembly (3) includes a screw gun (304). The Z-axis moving assembly drives the screw gun (304) to move up and down. The lower end of the screw gun (304) is equipped with a tightening gun head (305). The tightening gun head (305) reaches the set torque to tighten the screw (13) so that the cover plate (12) seals the reaction module (10).

11. The high-throughput automated chemical synthesis workstation according to any one of claims 1-10, characterized in that, The base (1) is equipped with a monitoring module (15), which monitors the entire working process.

12. The high-throughput automated chemical synthesis workstation according to any one of claims 1-11, characterized in that, The first mounting plate is a square plate, and each of the four bottom corners of the first mounting plate is fixedly equipped with a pad. The pads support the first mounting plate and the height of the pads is adjustable.

13. The high-throughput automated chemical synthesis workstation according to claim 5 or 6, characterized in that, A first handle (602) is fixedly mounted on one end of the first metal plate (601).

14. The high-throughput automated chemical synthesis workstation according to claim 5 or 6, characterized in that, Five first mounting plates (6) are provided, and four nozzle boxes (11) are provided, which are respectively placed on the first snap-fit ​​plates (603) of the two first mounting plates (6); four liquid storage tanks (14) are provided, which are respectively placed on the first snap-fit ​​plates (603) of the two first mounting plates (6).

15. The high-throughput automated chemical synthesis workstation according to any one of claims 1-6, characterized in that, The moving device (22) includes a support base (201), on which an X-axis slide rail (202) and an X-axis electric cylinder (203) are fixedly mounted. An X-axis slider (204) is slidably mounted on the X-axis slide rail (202), and the X-axis electric cylinder (203) is configured to drive the X-axis slider (204) to slide on the X-axis slide rail (202).

16. The high-throughput automated chemical synthesis workstation according to claim 15, characterized in that, The X-axis slider (204) is fixedly mounted with a Y-axis slide rail (205) and a Y-axis electric cylinder (207). The Y-axis slider (206) is slidably mounted on the Y-axis slide rail (205). The Y-axis electric cylinder (207) drives the Y-axis slider (206) to slide on the Y-axis slide rail (205). The tightening assembly (3), the gripper assembly (4), and the pipetting assembly (5) are all mounted on the Y-axis slider (206).

17. The high-throughput automated chemical synthesis workstation according to claim 16, characterized in that, The tightening assembly (3) includes a tightening electric cylinder (301) and a tightening slide rail (302). Both the tightening electric cylinder (301) and the tightening slide rail (302) are mounted on the Y-axis slider (206). A tightening slider (303) is slidably mounted on the tightening slide rail (302). The tightening electric cylinder (301) drives the tightening slider (303) to slide on the tightening slide rail (302). A screw gun (304) is fixedly mounted on the tightening slider (303), and a tightening gun head (305) is provided on the screw gun (304).

18. The high-throughput automated chemical synthesis workstation according to claim 16 or 17, characterized in that, The pipetting assembly (5) includes a pipetting slide rail (501) and a pipetting cylinder (502). The pipetting slide rail (501) and the pipetting cylinder (502) are mounted on the Y-axis slider (206). A pipetting slider (503) is slidably mounted on the pipetting slide rail (501). The pipetting cylinder (502) drives the pipetting slider (503) to slide on the pipetting slide rail (501). A pipetting tip (504) is fixedly mounted on the pipetting slider (503).

19. The high-throughput automated chemical synthesis workstation according to claim 18, characterized in that, The pipetting assembly (5) employs an eight-channel configuration for pipetting.

20. The high-throughput automated chemical synthesis workstation according to any one of claims 16-19, characterized in that, The gripper assembly (4) includes a movable electric cylinder (401) and a movable slide rail (402). The movable electric cylinder (401) and the movable slide rail (402) are mounted on the Y-axis slider (206). A movable block (403) is slidably mounted on the movable slide rail (402). The movable electric cylinder (401) drives the movable block (403) to slide on the movable slide rail (402).

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