Non-invasive glucose measurement device and method

Abstract

The present invention relates to a non-invasive glucose measurement device and method. To this end, the non-invasive glucose measurement device according to one embodiment of the present invention may comprise: a light irradiation unit which is positioned beneath an inner lower case disposed beneath an inserted finger, and which includes a first light-emitting element and a second light-emitting element for irradiating light toward the finger placed on the inner lower case; a light reception unit which is disposed on an inner upper case disposed on the finger, and which includes a first light-receiving element and a second light-receiving element for receiving the light irradiated from the light irradiation unit and transmitted through the finger; a motor unit including a first motor disposed at one side of the inner lower case and a second motor disposed at the other side of the inner lower case; a pressure sensor unit which is disposed beneath the inner lower case, and which includes a first pressure sensor and a second pressure sensor for measuring pressure applied by the finger; and a processor for measuring glucose by using the amount of light received through the light reception unit.

Description

Noninvasive glucose measurement device and method

[0001] The present invention relates to a non-invasive glucose measurement device and method.

[0002] It's reported that one in seven (13.8%) adults aged 30 and older in Korea suffer from diabetes. The prevalence of diabetes increases with age, with nearly three in ten adults aged 65 and older reportedly suffering from the condition, making diabetes one of the most prevalent diseases.

[0003] Representative measuring devices for measuring blood sugar include invasive measuring devices that measure blood sugar through a small amount of capillary blood instead of venous blood, and non-invasive measuring devices.

[0004] These conventional invasive blood glucose measurement devices measure blood glucose levels by pricking a fingertip or other site with a needle and then using a small amount of blood secreted. A prior document is Korean Patent Publication No. 10-1288400.

[0005] These conventional invasive blood glucose measuring devices measure blood glucose levels by pricking a fingertip or an alternative site with a needle and using a small amount of the secreted blood.

[0006] However, these conventional invasive blood glucose measurement devices require the user to insert a needle into the skin each time they measure, which not only causes pain to the user each time, but also risks introducing bacteria into the skin.

[0007] In addition, conventional non-invasive blood glucose measurement devices (e.g., continuous glucose monitoring system (CGMS)) measure the glucose concentration of interstitial fluid between tissues by inserting a needle-shaped sensor into the skin.

[0008] However, these conventional non-invasive blood glucose measurement devices are not truly non-invasive because they require sensors to be inserted into the skin. Furthermore, measuring blood glucose levels requires a complex, pain-inducing process: a fingertip lancet is used to inject a certain amount of capillary blood onto a test strip attached to the meter. This process not only presents hygiene and user inconvenience, but also results in low accuracy.

[0009] In addition, conventional non-invasive blood glucose measurement devices using light sources have limitations in obtaining accurate measurement results because they do not measure blood glucose by taking into account the pressure exerted by the finger.

[0010] Therefore, there is a need for a bloodless glucose measurement device that can accurately measure glucose by measuring finger pressure.

[0011] (Patent Document 1) Korean Patent Publication No. 10-1288400

[0012] Accordingly, the present invention provides a non-invasive glucose measurement device and method having two motors for fixing a finger.

[0013] In addition, the present invention provides a non-invasive glucose measurement device that controls the operation of at least one motor based on a pressure value obtained by pressure of a finger.

[0014] In addition, the present invention provides a non-invasive glucose measuring device that outputs light through two light-emitting elements having different wavelengths to accurately measure glucose.

[0015] In addition, the present invention provides a non-invasive glucose measurement device and method for measuring a user's glucose by converting a current corresponding to the amount of light of a light beam into a voltage, filtering the frequency of the converted voltage into a predetermined frequency band, and compensating the voltage of the filtered frequency.

[0016] The purposes of the present invention are not limited to those mentioned above, and other unmentioned purposes and advantages of the present invention can be understood through the following description and will be more clearly understood through embodiments of the present invention. Furthermore, it will be readily apparent that the purposes and advantages of the present invention can be realized by the means and combinations thereof set forth in the claims.

[0017] In order to achieve this purpose, a non-invasive glucose measurement device according to one embodiment of the present invention may include: a light emitting unit positioned at the lower portion of an internal lower case disposed below an inserted finger, and including a first light emitting element and a second light emitting element for emitting light toward the finger seated in the internal lower case; a light receiving unit positioned at the upper portion of an internal upper case disposed above the finger, and including a first light receiving element and a second light receiving element for receiving light irradiated from the light emitting unit and passing through the finger; a motor unit including a first motor disposed at one side of the internal lower case and a second motor disposed at the other side of the internal lower case; a pressure sensor unit positioned at the lower portion of the internal lower case, and including a first pressure sensor and a second pressure sensor for measuring pressure by the finger; and a processor for measuring glucose using the amount of light received through the light receiving unit.

[0018] In addition, in a method for measuring glucose in a non-invasive glucose measuring device according to an embodiment of the present invention, the non-invasive glucose measuring device includes a light emitting unit located at the lower portion of an internal lower case disposed below an inserted finger and including a first light emitting element and a second light emitting element for emitting light toward the finger seated in the internal lower case, a light receiving unit located at the upper portion of an internal upper case disposed above the finger and including a first light receiving element and a second light receiving element for receiving light radiated from the light emitting unit and passing through the finger, a motor unit including a first motor disposed at one side of the internal lower case and a second motor disposed at the other side of the internal lower case, and a pressure sensor unit disposed at the lower portion of the internal lower case and including a first pressure sensor and a second pressure sensor for measuring pressure by the finger, the method includes: a step of acquiring a first pressure value measured by the first pressure sensor and a second pressure value measured by the second pressure sensor; The method may include: comparing the difference between the first pressure value and the second pressure value with the size of a threshold value; measuring the pressure by controlling at least one of the first motor and the second motor so that the difference becomes less than or equal to the threshold value when the difference exceeds the threshold value; and measuring glucose by reflecting the measured pressure.

[0019] The present invention can fix a finger by using two motors, thereby improving the accuracy of glucose measurement.

[0020] In addition, the present invention can improve the accuracy of glucose measurement by obtaining an accurate pressure value by a finger by measuring the pressure according to the position of the finger through two pressure sensors and controlling the operation of the motor based on the measurement results.

[0021] In addition, the present invention can improve the accuracy of glucose measurement by outputting light to a finger through two light-emitting elements having different wavelengths and receiving light passing through the finger.

[0022] In addition to the effects described above, specific effects of the present invention are described below while explaining specific details for carrying out the invention.

[0023] FIG. 1 is a perspective view showing the appearance of a non-invasive glucose measuring device according to one embodiment of the present invention.

[0024] FIG. 2 is a perspective view illustrating an inlet hole of a non-invasive glucose measuring device according to one embodiment of the present invention.

[0025] FIG. 3 is a perspective view of a non-invasive glucose measuring device with the outer upper case removed according to one embodiment of the present invention.

[0026] FIG. 4 is a plan view of a non-invasive glucose measurement device with the outer upper case removed according to one embodiment of the present invention.

[0027] FIG. 5 is a perspective view showing a state in which the outer upper case and the outer lower case are removed from a non-invasive glucose measuring device according to one embodiment of the present invention.

[0028] FIG. 6 is a plan view showing a state in which the outer upper case and the outer lower case are removed from a non-invasive glucose measuring device according to one embodiment of the present invention.

[0029] FIG. 7 is a front view showing a state in which the outer upper case and the outer lower case are removed from a non-invasive glucose measuring device according to one embodiment of the present invention.

[0030] Figure 8 is an exemplary diagram showing a state in which switch members are arranged in an internal lower case according to one embodiment of the present invention.

[0031] FIG. 9 is an exemplary diagram showing a state in which a finger is inserted into a non-invasive glucose measurement device according to one embodiment of the present invention to measure glucose.

[0032] Figure 10 is a block diagram of a non-invasive glucose measurement device according to one embodiment of the present invention.

[0033] Figure 11 is a flowchart showing a process of measuring glucose using a non-invasive glucose measuring device according to one embodiment of the present invention.

[0034] FIG. 12 is an exemplary diagram showing a home screen displayed on an input / output unit of a non-invasive glucose measurement device according to one embodiment of the present invention.

[0035] FIG. 13 is an exemplary diagram showing a status bar displayed on an input / output unit of a non-invasive glucose measurement device according to one embodiment of the present invention.

[0036] FIG. 14 is an exemplary diagram of measuring glucose using a non-invasive glucose measuring device according to one embodiment of the present invention.

[0037] Figure 15 is an exemplary diagram showing the results of measuring glucose using a non-invasive glucose measuring device according to one embodiment of the present invention.

[0038] FIG. 16 is an exemplary diagram showing accumulated data according to the time point at which glucose was measured using a non-invasive glucose measuring device according to an embodiment of the present invention.

[0039] FIG. 17 is a flowchart showing a process of measuring glucose by reflecting pressure from a finger measured by controlling a motor according to one embodiment of the present invention.

[0040] Figure 18 is a flowchart showing a process for measuring glucose using different wavelengths according to one embodiment of the present invention.

[0041] FIG. 19 is an exemplary diagram showing absorption rates after different wavelengths pass through a finger according to one embodiment of the present invention.

[0042] The above-described objects, features, and advantages will be described in detail below with reference to the accompanying drawings, so that those skilled in the art can easily practice the technical idea of ​​the present invention. In describing the present invention, if it is determined that a detailed description of known technologies related to the present invention may unnecessarily obscure the gist of the present invention, a detailed description thereof will be omitted. Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the drawings, the same reference numerals are used to indicate the same or similar components.

[0043] Although terms like "first" and "second" are used to describe various components, these components are not limited by these terms. These terms are used merely to distinguish one component from another, and unless otherwise specified, a "first" component may also be a "second" component.

[0044] Hereinafter, the phrase "any configuration is placed on (or below)" a component or "on (or below)" a component may mean that any configuration is placed in contact with the upper surface (or lower surface) of said component, and that other configurations may be interposed between said component and any configuration placed on (or below) said component.

[0045] Additionally, when it is described that a component is "connected," "coupled," or "connected" to another component, it should be understood that the components may be directly connected or connected to one another, but that other components may also be "interposed" between the components, or that each component may be "connected," "coupled," or "connected" through another component.

[0046] Throughout the specification, unless otherwise specifically stated, each element may be singular or plural.

[0047] As used herein, singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, terms such as "consisting of" or "comprising" should not necessarily be construed to include all of the components or steps described in the specification, and should be construed to mean that some of the components or steps may not be included, or that additional components or steps may be included.

[0048] Throughout the specification, when we refer to "A and / or B", this means A, B, or A and B, unless otherwise stated, and when we refer to "C to D", this means C or more and D or less, unless otherwise stated.

[0049] Hereinafter, a non-invasive glucose measurement device and method according to some embodiments of the present invention will be described.

[0050] Fig. 1 is a perspective view illustrating the exterior of a non-invasive glucose measurement device according to an embodiment of the present invention. Fig. 2 is a perspective view illustrating an inlet hole of a non-invasive glucose measurement device according to an embodiment of the present invention.

[0051] Referring to FIGS. 1 and 2, a non-invasive glucose measurement device (100) according to an embodiment of the present invention has a display unit (130) and a light-emitting unit (151) arranged on the upper surface. In addition, the exterior of the non-invasive glucose measurement device (100) is formed by an outer upper case (110) and an outer lower case (120), and a hole cover (140) covering an insertion hole (210) into which a finger is inserted is arranged on one side of the non-invasive glucose measurement device (100).

[0052] FIG. 3 is a perspective view of a noninvasive glucose measurement device with the outer upper case removed according to an embodiment of the present invention. FIG. 4 is a plan view of a noninvasive glucose measurement device with the outer upper case removed according to an embodiment of the present invention. FIG. 5 is a perspective view showing a state in which the outer upper case and the outer lower case are removed from the noninvasive glucose measurement device with the outer upper case and the outer lower case removed according to an embodiment of the present invention. FIG. 6 is a plan view showing a state in which the outer upper case and the outer lower case are removed from the noninvasive glucose measurement device with the outer upper case and the outer lower case removed according to an embodiment of the present invention. FIG. 7 is a front view showing a state in which the outer upper case and the outer lower case are removed from the noninvasive glucose measurement device with the outer upper case and the outer lower case removed according to an embodiment of the present invention. FIG. 8 is an exemplary view showing a state in which switch members are arranged in an inner lower case according to an embodiment of the present invention. FIG. 9 is an exemplary view showing a state in which a finger is inserted into the noninvasive glucose measurement device with glucose measured according to an embodiment of the present invention.

[0053] Referring to FIGS. 3 to 9, an inner lower case (320) is placed inside an outer lower case (120) of a non-invasive glucose measuring device (100), and an inner upper case (310) is placed inside an outer upper case (110).

[0054] According to one embodiment, the inner upper case (310) is positioned above the inner lower case (320) and is movable in an upward or downward direction by a motor unit. For example, the motor unit may include a first motor unit (331) positioned on one side of the inner upper case (310) and a second motor unit (332) positioned on the other side of the inner upper case (310).

[0055] According to one embodiment, a first adjustment unit (370) is arranged on one side of the inner upper case (310), and a second adjustment unit (380) is arranged on the other side of the inner upper case (310). For example, the first adjustment unit (370) and the second adjustment unit (380) may be arranged symmetrically with respect to the inner upper case (310), or may be arranged at non-symmetrical positions.

[0056] According to one embodiment, the first control unit (370) may include a first gear (361) that rotates clockwise or counterclockwise by the power of the first motor unit (331), a first rack gear (341) that is coupled to one side of the inner upper case (310) and moves upward or downward by the rotation of the first gear (361), and a first rail (351) that guides the movement of the first rack gear (341).

[0057] According to one embodiment, the first rack gear (341) is formed to move upward or downward along the first rail (351) while meshing teeth with the first gear (361). For example, when the first gear (361) rotates clockwise, the first rack gear (341) moves upward, and as the first rack gear (341) moves upward, the internal upper case (310) moves upward. Conversely, when the first gear (361) rotates counterclockwise, the first rack gear (341) moves downward, and as the first rack gear (341) moves downward, the internal upper case (310) moves downward.

[0058] According to one embodiment, the second control unit (380) may include a second gear (362) that rotates clockwise or counterclockwise by the power of the second motor unit (332), a second rack gear (342) that is coupled to the other side of the inner upper case (310) and moves upward or downward by the rotation of the second gear (362), and a second rail (352) that guides the movement of the second rack gear (342).

[0059] According to one embodiment, the second rack gear (342) is formed to move upward or downward along the second rail (352) while meshing teeth with the second gear (362). For example, when the second gear (362) rotates counterclockwise, the second rack gear (342) moves upward, and as the second rack gear (342) moves upward, the inner upper case (310) moves upward. Conversely, when the second gear (362) rotates clockwise, the second rack gear (342) moves downward, and as the second rack gear (342) moves downward, the inner upper case (310) moves downward.

[0060] According to one embodiment, the inner upper case (320) can move upward or downward by the operation of either the first gear (361) or the second gear (362). For example, when only one of the first motor unit (331) or the second motor unit (332) operates, the other does not transmit power to the corresponding gear. Accordingly, the gear that does not receive power is rotated by the gear that receives power.

[0061] In this way, using two motors allows for precise finger positioning regardless of finger thickness, minimizing misreading by stabilizing finger movement. To achieve this, each motor's movement distance and speed can be precisely controlled through logic design.

[0062] According to one embodiment, a plurality of holes are formed on the lower surface of the inner lower case (320). For example, a first hole (421) formed to allow light emitted from a first light-emitting element to pass through, and a second hole (422) formed to allow light emitted from a second light-emitting element to pass through, are formed on the lower surface of the inner lower case (320).

[0063] In addition, holes are formed on the lower surface of the inner lower case (320) to allow the respective protrusions (411, 412) of the switch members (830, 840) to protrude in addition to the first hole (421) and the second hole (422) to be described later.

[0064] Additionally, a hole may be formed on the lower surface of the inner lower case (320) to measure the temperature of a finger by a temperature sensor (431).

[0065] For example, five holes can be formed on the lower surface of the inner lower case (320).

[0066] According to one embodiment, the outer lower case (120) and the outer upper case (110) can be joined by bolts (401). For example, it is preferable that there are four bolts.

[0067] According to one embodiment, a PCB (Printed Circuit Board) (510) may be placed on the bottom (i.e., the bottom of the inner lower case (320)) of the non-invasive glucose measurement device (100). The PCB is formed in a laminated structure of conductors and insulators in the form of a substrate, and various components such as semiconductors, capacitors, and resistors may be mounted thereon, and electrical connections are made therebetween.

[0068] Additionally, the PCB (510) may have two light irradiation units (501, 502), two pressure sensor units (810, 820), and a temperature sensor (431) arranged thereon.

[0069] According to one embodiment, a top cover (710) may be placed on the lower surface of the inner upper case (310). This top cover (710) has a round shape corresponding to the shape of a finger, and is substantially in close contact with a finger placed on the inner lower case (320) to support the finger.

[0070] According to one embodiment, the top cover (710) may be connected to the inner upper case (310) so as to move independently of the inner upper case (310).

[0071] Alternatively, in order for the top cover (710) to be substantially in close contact with the finger, a separate motor (not shown) may be mounted on the upper part of the top cover (710) in addition to the first motor unit (331) and the second motor unit (332). The top cover (710) can be moved in an upward or downward direction by this motor (not shown).

[0072] According to one embodiment, a first switch member (830) and a second switch member (840) may be arranged at the lower portion of the inner lower case (320).

[0073] According to one embodiment, the first switch member (830) is disposed between the inner lower case (320) and the PCB (510) to transmit pressure from a finger (910) to the first pressure sensor (810).

[0074] According to one embodiment, the first switch member (830) can transmit pressure (i.e., pressure by a finger) applied to a first protrusion (411) inserted into a hole formed in the lower portion of the inner lower case (320) to the first pressure sensor (810). The first switch member (830) is fluidly coupled to the inner lower case (320) so that the first pressure protrusion (832) can move downward to where the first pressure sensor (810) is located by downward pressure on the first protrusion (411) by a finger. To this end, the first protrusion (411) is physically connected to the first pressure protrusion (832) by the first support member (831).

[0075] According to one embodiment, a spring is arranged inside the first switch member (830). Due to this spring, the first switch member (830) can move downward when pressed by a finger, and return to its original position when not pressed.

[0076] In this way, the first switch member (830) has a first protrusion (411) formed on the upper surface, and a first pressure protrusion (832) formed on the lower surface for pressing the first pressure sensor (810).

[0077] For example, the first protrusion (411) and the hole into which the first protrusion (411) is inserted have a circular shape, and it is preferable that the diameter of the first protrusion (411) be formed to be smaller than the diameter of the hole.

[0078] For example, the surface of the first pressure protrusion (832) that comes into contact with the first pressure sensor (810) and the surface of the first pressure sensor (810) may have the same area (or the same shape).

[0079] According to one embodiment, the second switch member (840) is disposed between the inner lower case (320) and the PCB (510) to transmit pressure from a finger (910) to the second pressure sensor (820).

[0080] According to one embodiment, the second switch member (840) can transmit pressure (i.e., pressure by a finger) applied to a first protrusion (412) inserted into a hole formed in the lower portion of the inner lower case (320) to the second pressure sensor (820). The second switch member (840) is fluidly coupled to the inner lower case (320) so that the second pressure protrusion (842) can move downward to where the second pressure sensor (820) is located by downward pressure of the second protrusion (412) by a finger. To this end, the second protrusion (412) is physically connected to the second pressure protrusion (842) by the second support member (821).

[0081] According to one embodiment, a spring is arranged inside the second switch member (840). Due to this spring, the second switch member (840) can move downward when pressed by a finger, and return to its original position when not pressed.

[0082] In this way, the second switch member (840) has a second protrusion (412) formed on the upper surface and a second pressure protrusion (842) formed on the lower surface for pressing the second pressure sensor (820).

[0083] For example, the second protrusion (412) and the hole into which the second protrusion (412) is inserted have a circular shape, and it is preferable that the diameter of the second protrusion (412) be formed to be smaller than the diameter of the hole.

[0084] For example, the surface of the second pressure protrusion (842) that comes into contact with the second pressure sensor (820) and the surface of the second pressure sensor (820) may have the same area (or the same shape).

[0085] The present invention can control the operation of motors based on the average value of the pressure value measured by the first pressure sensor (810) and the pressure value measured by the second pressure sensor (820).

[0086] Additionally, by using two pressure sensors, errors depending on the pressure measurement location can be reduced.

[0087] Additionally, it has a function that determines a measurement error when the pressure change exceeds 30% during the measurement time and notifies the user to remeasure.

[0088] According to one embodiment, the first temperature sensor (431) may be placed on the lower part of the inner lower case (320) to measure the temperature of the lower surface of the finger, and the second temperature sensor (432) may be placed on the upper part of the inner upper case (310) to measure the temperature of the upper surface of the finger.

[0089] According to one embodiment, a spherical lens and an aspherical lens may be respectively arranged on the upper portions of the first light-emitting element and the second light-emitting element (501) within the first light-emitting element (501). For example, a spherical lens may be arranged on the upper portion of each light-emitting element, and an aspherical lens may be arranged on the upper portion of the spherical lens. Preferably, each light-emitting element (501) is arranged with two lenses.

[0090] An aspherical lens is a lens that has both the front and back surfaces convex and aspherical, and the refractive indices of the front and back surfaces can be different.

[0091] According to one embodiment, each light emitting section is formed in a cylindrical shape to allow light to pass through. In addition, a support section is formed inside each light emitting section to support and secure an aspherical lens.

[0092] In one embodiment, a spherical lens may be positioned above the light-emitting element to transmit light emitted from the light-emitting element to the aspherical lens. For example, the spherical lens may be positioned on the upper surface of a cover molded from plastic.

[0093] In one embodiment, an aspherical lens is positioned on top of a spherical lens and can convert non-parallel rays passing through the spherical lens into parallel rays for output. For example, the aspherical lens has a refractive index that can convert non-parallel rays passing through the spherical lens into parallel incident rays.

[0094] For this purpose, the aspherical lens can be placed at a position spaced apart from the spherical lens by a certain distance in the upper direction of the spherical lens.

[0095] Figure 10 is a block diagram of a non-invasive glucose measurement device according to one embodiment of the present invention.

[0096] Referring to FIG. 10, a non-invasive glucose measurement device (100) according to an embodiment of the present invention may include a light irradiation unit (501, 502), a light reception unit (911, 912), a pressure sensor unit (810, 820), a temperature sensor unit (431, 432), a motor unit (331, 332), and a control unit (1000).

[0097] According to one embodiment, the control unit (1000) may include a current / voltage converter (1010), a filter (1020), an amplifier (1030), an A / D converter (1040), a regulator (1050), a memory (1060), a communication unit (1070), an input / output unit (1080), and a processor (1090).

[0098] The configuration of the non-invasive glucose measuring device (100) illustrated in FIG. 10 is according to one embodiment, and the components of the non-invasive glucose measuring device (100) are not limited to the embodiment illustrated in FIG. 10, and some components may be added, changed, or deleted as needed.

[0099] According to one embodiment, the light irradiating unit (501, 502) may include at least one light emitting element (e.g., an LED) that outputs light for glucose measurement. The light irradiating unit (501, 502) allows the light to pass through the internal tissue of the finger (901).

[0100] These light irradiation units (501, 502) are located on one side of the inner lower case (320) of the non-invasive glucose measurement device (100), and can irradiate light toward a finger (901) placed in the inner lower case (320) by being introduced into the inlet hole (210).

[0101] According to one embodiment, the light receiving unit (911, 912) may include a photodiode having high photosensitivity in a predetermined wavelength band (e.g., 800 nm to 940 nm) to receive a small amount of light. Such a photodiode may have various sizes.

[0102] The light receiving unit (911, 912) can receive the amount of light transmitted through various reactions such as reflection, absorption, scattering, and transmission with substances within the tissue of the finger (901). Absorption by the components that make up the skin is minimal, mainly in the near-infrared region, and the greatest influence is scattering. The refraction and scattering of light occur due to the difference in refractive index between various components that make up the tissue of the body, and the greater the difference in refractive index between the substance causing scattering and the surrounding substances, the greater the degree of scattering.

[0103] For example, when the glucose concentration in blood and interstitial fluid (ISF) increases, the refractive index increases, reducing the difference in refractive index with surrounding substances. This reduces the scattering coefficient and increases the intensity of transmitted light.

[0104] Considering this operating principle, the angle of the incident light has a significant impact on the blood glucose measurement results, and the larger the distribution of the incident angle, the greater the measurement variables may be.

[0105] Taking this into consideration, the light receiving unit (911, 912) is located on the upper part of the inner upper case (310) with the finger (901) in between, and can receive light irradiated from the light irradiation unit (501, 502) and transmitted through the finger (901).

[0106] For example, the first light-receiving element in the first light-receiving unit (911) can receive light that is output from the first light-emitting element and passes through the finger (901), and the second light-receiving element in the second light-receiving unit (912) can receive light that is output from the second light-emitting element and passes through the finger (901). To this end, the first light-emitting element and the first light-receiving element can be arranged in a direction perpendicular to each other, and the second light-emitting element and the second light-receiving element can be arranged in a direction perpendicular to each other.

[0107] According to one embodiment, the pressure sensor unit (810, 820) can measure the pressure exerted by a finger (901). When the finger (901) is placed on the inner lower case (320), the finger (901) comes into contact with the surface of the inner lower case (320) and applies pressure, and the pressure sensor unit (810, 820) can measure this pressure. In addition, the pressure sensor unit (810, 820) can transmit the measured pressure value to the processor (1090).

[0108] For example, the pressure sensor unit (810, 820) can measure pressure once or measure it multiple times in real time while measuring glucose.

[0109] These pressure sensor units (810, 820) may include an ultra-low power integrated pressure sensor unit with a built-in analog front-end.

[0110] For example, the pressure sensor unit (810, 820) may have a measurement range of a load of 5 g to 4 kg.

[0111] According to one embodiment, the temperature sensor unit (431, 432) may include a first temperature sensor (431) that measures the temperature of the lower surface of the finger (901) and a second temperature sensor (432) that measures the temperature of the upper surface of the finger (901). The temperature sensor unit (431, 432) may transmit the measured temperature to the processor (1090).

[0112] For example, the temperature sensor unit (431, 432) can measure the temperature once or measure it multiple times in real time while measuring glucose.

[0113] According to one embodiment, the motor units (331, 332) are respectively located on one side and the other side of the inner lower case (320) and are electrically coupled to the PCB (510) and provide power so that the finger (901) is brought into close contact with the inner lower case (320).

[0114] For example, the first motor unit (331) may be placed on one side of the inner lower case (320), and the second motor unit (332) may be placed on the other side of the inner lower case (320). The first motor unit (331) and the second motor unit (332) may be operated to adjust the height of the inner upper case (310).

[0115] According to one embodiment, the control unit (1000) may include a current / voltage converter (1010), a filter (1020), an amplifier (1030), an A / D converter (1040), and a regulator (1050).

[0116] According to one embodiment, the current / voltage converter (1010) can convert the input current to be measured into a corresponding voltage and output it. When the light receiving unit (911, 912) (e.g., photodiode) detects light, it generates a microcurrent (I d ) is generated. The current / voltage converter (1010) converts this microcurrent into a transimpedance gain resistor (R f) is converted into an output voltage. The output voltage is obtained by multiplying the microcurrent and the gain resistor. The current / voltage converter (1010) converts the amount of light output from the light receiving unit (911, 912) into voltage (e.g., mV) data and then provides it to the filter (1020).

[0117] According to one embodiment, the filter (1020) may filter the frequency of the voltage output from the current / voltage converter (1010). For example, the filter (1020) may include a low-pass filter. The filter (1020) may pass only a frequency signal of a predetermined frequency band (e.g., 10 Hz or less) and filter the remaining frequency band to be transmitted to the amplifier (1030).

[0118] According to one embodiment, the controller (1050) can adjust the gain value to correspond to the user's condition for measuring glucose. The amplifier (1030) can amplify the signal (e.g., amplify the voltage of the signal) by reflecting the gain value corresponding to the user's condition transmitted from the controller (1050) to the signal that has passed through the filter (1020). For example, the amplifier (1030) can amplify the voltage from 3.3 V to 5 V. The signal output from the amplifier (1030) can be an analog signal.

[0119] For example, each person's finger thickness, skin color, and condition may vary. The greater the variation in these conditions, the more accurate the gain value can be set based on the user's specific conditions to accurately measure glucose levels.

[0120] According to one embodiment, the A / D converter (1040) can convert an analog signal output from the amplifier (1030) into a digital signal. The A / D converter (1040) can convert an input analog signal into a digital signal at a speed of 20 SPS (sampling rate per second).

[0121] According to one embodiment, the memory (1060) may include volatile memory or non-volatile memory. For example, the memory (1060) may store information, data, programs, etc. necessary for the operation of the non-invasive glucose measurement device (100). Accordingly, the processor (1090) may perform the control operation described below by referring to the information stored in the memory (1060).

[0122] The above memory (1060) may store various platforms. The memory (1060) may include, for example, at least one type of storage medium among a flash memory type, a hard disk type, a multimedia card micro type, a card type memory (e.g., SD or XD memory, etc.), RAM, and ROM (e.g., EEPROM).

[0123] The above memory (1060) can store various data (e.g., software, applications, programs, control logic, control signals, light quantity data acquired through the light receiving unit (911, 912), information acquired through the input / output unit (1080) (e.g., touch input, voice message, etc.)) acquired or used by at least one component of the non-invasive glucose measuring device (100), and commands related thereto.

[0124] The above memory (1060) can store information, commands, software, data, programs, etc. regarding the operation of the non-invasive glucose measurement device (100). In addition, the memory (1060) can store data input to the processor (1090), data being processed, and / or data according to the processing result.

[0125] Additionally, the memory (1060) may store in advance information about a user who measures glucose using a non-invasive glucose measuring device (100) and a program for measuring glucose.

[0126] According to one embodiment, the communication unit (1070) may include at least one circuit capable of transmitting and receiving at least one signal, information, or data with another electronic device (not shown) (e.g., a mobile terminal or a server).

[0127] In addition, the communication unit (1070) can perform wired or wireless communication with other electronic devices based on short-range communication (e.g., at least one of Wi-Fi (Wireless-Fidelity), Wi-Fi Direct, Wireless USB (Wireless Universal Serial Bus), Bluetooth, RFID (Radio Frequency Identification), Infrared Data Association, UWB (Ultra Wideband), ZigBee, NFC (Near Field Communication), and Beacon).

[0128] The above communication unit (1070) can receive a program for measuring glucose from a mobile terminal (not shown) or a server (not shown) and store the received program in the memory (1060) under the control of the processor (1090).

[0129] According to one embodiment, the input / output unit (1080) may include a display unit (130) that displays or receives various information according to the operation of the non-invasive glucose measurement device (100), a speaker (1082) that outputs a voice signal, a microphone (1083) that receives a voice, a light-emitting unit (151) that includes at least one light-emitting element, and an interface unit (1081) that provides a physical connection (e.g., USB, HDMI, etc.) with another electronic device (e.g., a charger, a display device, etc.).

[0130] For example, the display unit may include a touch sensing circuit that detects a user's touch input.

[0131] According to one embodiment, the processor (1090) can control components of a noninvasive glucose measurement device (100).

[0132] The above processor (1090) may be implemented as at least one physical element among application specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), processors, micro-controllers, and microprocessors.

[0133] The processor (1090) may be equipped with an artificial intelligence algorithm. This artificial intelligence algorithm may be implemented by the processor (1090). The artificial intelligence, a program imitating the human brain neural network, can support deep learning algorithms that independently analyze, recognize, infer, and judge various data.

[0134] Through this, the processor (1090) can control the glucose measurement of the non-invasive glucose measurement device (100) using artificial intelligence.

[0135] In this way, the processor (1090) may include a circuit that can control the components of the non-invasive glucose measurement device (100) in general.

[0136] According to one embodiment, the processor (1090) can perform an operation of measuring glucose through a non-invasive glucose measuring device (100), a specific description of which is as follows.

[0137] Additionally, an operation performed in the processor (1090) may be interpreted as being performed in the control unit (1000), and similarly, an operation performed in the control unit (1000) may be interpreted as being performed in the processor (1090).

[0138] According to one embodiment, the processor (1090) may control the light irradiation units (501, 502) to output a first light beam of a first wavelength (e.g., 600 nm to 800 nm) toward the finger (901) through the first light emitting element of the first light irradiation unit (501), and output a second light beam of a second wavelength (e.g., 800 nm to 1000 nm) having a different wavelength from the first wavelength (e.g., 600 nm to 800 nm) toward the finger (901) through the second light emitting element of the second light irradiation unit (502). In this way, the reason the light emitting elements output light beams of different wavelengths is to detect and measure the amount of light transmitted through reactions such as reflection, absorption, scattering, and transmission inside the human body.

[0139] According to one embodiment, the processor (1090) can obtain a first light quantity by a first light beam passing through a finger (901) through a first light receiving element of a first light receiving unit (911), and can obtain a second light quantity by a second light beam passing through the finger (901) through a second light receiving element of the second light receiving unit (912).

[0140] According to one embodiment, the processor (1090) may calculate a ratio of the first light quantity and the second light quantity (e.g., a ratio of the second light quantity to the first light quantity) and reflect the calculated ratio in the light quantity obtained through the light receiving unit (911, 912). The processor (1090) may apply the difference in the light quantity detected by the first light receiving element and the second light receiving element as a calculated variable when calculating the glucose concentration through a data analysis algorithm, thereby improving the accuracy of glucose measurement.

[0141] According to one embodiment, the processor (1090) may compare the difference between the first pressure value measured by the first pressure sensor (810) and the second pressure value measured by the second pressure sensor (820) with the size of a threshold value. The threshold value is a pressure value set to measure glucose more accurately by reflecting the pressure value by a finger when measuring glucose.

[0142] For example, the smaller the difference between the first pressure value and the second pressure value, the more likely it is that the finger is applying pressure evenly to the inner lower case (320). Additionally, the larger the difference between the first pressure value and the second pressure value, the more likely it is that the finger is not applying pressure evenly to the inner lower case (320).

[0143] According to one embodiment, the processor (1090) can be configured to specify a normal pressure range through a user interface program (UI) before measuring glucose, and can perform zero point correction before measurement to lower the inner upper case (310) by a set distance through motor control when the next measurement begins. This is to enable the motor's movement distance to be finely adjusted to fall within the normal pressure range when the measured pressure value falls outside the set range.

[0144] According to one embodiment, if the difference exceeds the threshold value, the processor (1090) can control the operation of at least one of the first motor unit (331) and the second motor unit (332) to adjust the height of the inner upper case (310) so that the difference becomes less than or equal to the threshold value. Thereafter, the processor (1090) can measure the pressure after the height of the inner upper case (310) is adjusted.

[0145] According to one embodiment, when the difference exceeds the threshold value, the processor (1090) can simultaneously control the first motor unit (331) and the second motor unit to raise (or lower) the upper case (310) so that the difference becomes less than or equal to the threshold value, thereby controlling the motor so that the difference does not exceed the threshold value.

[0146] According to one embodiment, when the difference exceeds the threshold value, the processor (1090) lowers the inner upper case (310) and controls a motor corresponding to a larger pressure value among the first pressure value and the second pressure value to raise the inner upper case (310) so that the difference does not exceed the threshold value, thereby controlling a motor corresponding to a smaller pressure value among the first pressure value and the second pressure value.

[0147] Thereafter, the control unit (1000) converts the current corresponding to the light quantity received from the light receiving unit (911, 912) into voltage, filters the frequency of the converted voltage into a predetermined frequency band, and compensates for the voltage of the filtered frequency to measure the user's glucose. These light receiving units (911, 912) may be placed at a position facing the light irradiation unit (501, 502) with a finger between them.

[0148] According to one embodiment, the control unit (1000) may include a current / voltage converter (1010) that converts current for light quantity into voltage, a filter (1020) that filters the frequency of the converted voltage into the predetermined frequency band, a controller (1050) that adjusts a gain value to correspond to a condition of a user measuring glucose, an amplifier (1030) that amplifies the voltage by reflecting the adjusted gain value to the voltage of the filtered frequency, an A / D (Analog to Digital) converter that converts the amplified voltage value into a digital voltage value, and a processor (1090) that is set to measure the user's glucose using the converted digital voltage value.

[0149] According to one embodiment, the control unit (1000) may further include an input / output unit (1080) that outputs measured glucose. For example, the input / output unit (1080) may further include a display unit (130) that displays various information about the operating status and operation results of the glucose measurement device (100) and receives a user's touch input, a speaker (1082) that outputs sound about the operating status and operation results of the non-invasive glucose measurement device (100), a microphone (1083) that receives sound, a light-emitting unit (151) that includes at least one light-emitting element, and an interface unit (1081) that provides a physical connection (or communication connection) with an external electronic device.

[0150] According to one embodiment, the control unit (1000) (e.g., processor (1090)) can obtain pressure due to pressing of a finger (901) through a pressure sensor unit (810, 820) and compensate for an error rate for glucose measurement by reflecting the pressure in a digital voltage value converted by an A / D converter (1040).

[0151] According to one embodiment, the processor (1090) can identify a change in at least one of intracellular fluid (ICF) and interstitial fluid of the finger (901) based on light transmitted through the finger, and can identify a change in scattering and refractive index according to a change in at least one of the intracellular fluid and the interstitial fluid. In addition, the processor (1090) can detect a change in the amount of light based on the identified change in refractive index.

[0152] The concentration of this interstitial fluid is highly correlated with the blood sugar concentration. Most of the components of interstitial fluid share similar characteristics, including ions, proteins, sugars, and alcohols, with the exception of large molecular weight substances such as lipids.

[0153] Glucose ingested through food is first absorbed into the bloodstream and then transported to cells, where it is converted into energy and used. During this process, glucose first travels through the endothelium of capillaries into the interstitial fluid. During this process, a lag time of approximately 3 to 12 minutes may occur as the concentration equilibrates due to diffusion caused by concentration differences. Therefore, it is recommended to wait approximately 3 to 12 minutes after ingestion before measuring glucose levels.

[0154] The non-invasive glucose measurement device (100) according to the present invention can measure blood sugar levels through the influence of light scattering through skin tissue.

[0155] According to one embodiment, the processor (1090) can identify a change in refractive index by detecting an angle of incidence of light irradiated to a finger (901) and an angle of refraction refracted by the finger.

[0156] FIG. 11 is a flowchart showing a process of measuring glucose using a noninvasive glucose measurement device according to an embodiment of the present invention. FIG. 12 is an exemplary diagram showing a home screen displayed on an input / output unit of a noninvasive glucose measurement device according to an embodiment of the present invention. FIG. 13 is an exemplary diagram showing a status bar displayed on an input / output unit of a noninvasive glucose measurement device according to an embodiment of the present invention. FIG. 14 is an exemplary diagram showing glucose measurement using a noninvasive glucose measurement device according to an embodiment of the present invention. FIG. 15 is an exemplary diagram showing the results of glucose measurement using a noninvasive glucose measurement device according to an embodiment of the present invention. FIG. 16 is an exemplary diagram showing accumulated data according to the time point of glucose measurement using a noninvasive glucose measurement device according to an embodiment of the present invention.

[0157] Hereinafter, with reference to FIGS. 11 to 16, a process of measuring glucose using a non-invasive glucose measuring device according to an embodiment of the present invention will be described in detail.

[0158] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) can detect input for glucose measurement through an input / output unit (1080) (S1110). For example, the processor (1090) can detect various inputs for glucose measurement through the input / output unit (1080).

[0159] According to one embodiment, the processor (1090) can display an initial screen for measuring glucose through the input / output unit (1080) (e.g., the display unit (130)). The display unit (130) can display various information or data, and can also include a touch detection sensor that detects touch input.

[0160] Referring to FIG. 12, the processor (1090) can display a program (e.g., a program for measuring glucose) stored in the memory (1060) through the input / output unit (1080) (e.g., the display unit (130)).

[0161] The above processor (1090) can display a screen (1210) including various icons regarding the timing of measuring glucose (e.g., wake-up icon (1211), before-breakfast icon (1219), before-lunch icon (1213), before-dinner icon (1214), before-bedtime icon (1215), after-breakfast icon (1216), after-lunch icon (1217), after-dinner icon (1218)).

[0162] For example, if a user wants to measure glucose immediately after waking up in the morning, the user can select the wake-up icon (1211) to measure glucose. Similarly, if a user wants to measure glucose after lunch, the user can select the after-lunch icon (1217) to measure glucose.

[0163] When the processor (1090) is powered on, it can display these various icons on the display unit (130).

[0164] Each of these icons is selected by the user to input the time at which the glucose measurement is to be performed. In this way, the processor (1090) can provide an intuitive interface to the user.

[0165] Additionally, the screen (1210) may include various information regarding the current time (1219), communication activation information (e.g., Bluetooth (1220)), remaining battery level information (1221), and environment settings (1222).

[0166] Referring to FIG. 13, the processor (1090) may display a screen (1310) for a status bar of a program (e.g., a program for measuring glucose). For example, when the environment setting (1222) is selected in FIG. 12, the processor (1090) may display a screen (1310) containing information on detailed settings of the non-invasive glucose measuring device (100) through the input / output unit (1080) (e.g., the display unit (130)).

[0167] For example, the screen (1310) may include a home icon (1302) indicating a home screen (1210), a Bluetooth icon (1303) for communication activation, a battery type (1304), and a detailed detailed setting icon (1305) of a non-invasive glucose measurement device (100).

[0168] These screens (1310) may include the current date, a home screen navigation icon, a Bluetooth connection status, a battery charge status, and a settings screen navigation icon.

[0169] According to one embodiment, when the post-meal icon (1217) of FIG. 12 is selected, the processor (1090) may display a screen (1410) for measuring glucose through the input / output unit (1080) (e.g., the display unit (130)), as shown in FIG. 14.

[0170] Referring to FIG. 14, the screen (1410) is an example of measuring glucose after a meal, and may include information indicating a measurement time (1413), a home menu (1411), a measurement start menu (1412), information indicating measurement-related information (1415), and information indicating a measurement progress rate (1416).

[0171] According to one embodiment, when a user selects a measurement start menu (1412) to measure glucose, the processor (1090) starts the glucose measurement process of the non-invasive glucose measurement device (100).

[0172] For example, the screen (1410) may include values ​​of transmittance information (e.g., DC component), temperature (e.g., 32 degrees), and pressure (e.g., 2100) and graphs (1415) for each.

[0173] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) can irradiate a light source through a light irradiation unit (501, 502) (S1112). When the processor (1090) detects that a measurement start menu (1412) is selected on the screen (1410), it can operate the light irradiation unit (501, 502) to output a light source toward a finger (901).

[0174] For example, the processor (1090) can output light having a predetermined wavelength (e.g., 630 nm) through the light irradiation unit (501, 502).

[0175] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) can obtain the amount of light transmitted through a finger (901) through a light receiving unit (911, 912) (S1114). When light is transmitted through the finger, the light receiving unit (911, 912) can obtain a signal value according to the change in blood flow due to contraction and expansion of the heart. When light is irradiated to the finger from the light irradiation unit (501, 502), light absorption occurs in the blood, bones, and tissues, and some of the light is transmitted and reaches the light receiving unit (911, 912).

[0176] The amount of light absorbed by a finger is proportional to the amount of skin, tissue, and blood present in the light's path. These factors remain constant except for changes in blood flow due to heartbeat, so the amount of light absorbed is proportional to the change in blood glucose. If blood glucose levels increase, the refractive index decreases, reducing the misalignment of light penetrating the tissues, resulting in less light being absorbed.

[0177] And, as the intensity of light crossing the tissue of the finger increases, the amplitude of the base component (e.g., DC component) of the photoplethysmography (PPG) signal and the pulsatile component (e.g., AC component), which is a pure blood flow fluctuation, are affected, and the light receiving unit (911, 912) can detect the change in amplitude. The AC component passes through a filter (1020) and an amplifier (1030) to remove high-frequency noise caused by the pulse.

[0178] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) can convert the current for the acquired light amount into voltage (S1116). The processor (1090) converts the microcurrent (I) output through the light receiving unit (911, 912) d ) to a current / voltage converter (1010) (e.g., transimpedance gain resistor (R f )) through the output voltage (V out ) is converted to .

[0179] For example, the processor (1090) may output a microcurrent (I) through a current / voltage converter (1010). d ) and transimpedance gain resistor (R f ) to obtain the output voltage (V out ) can be obtained.

[0180] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) may filter the frequency of the converted voltage through a filter (1020) so that only a predetermined frequency band passes (S1118). The processor (1090) may output an output voltage (V) output through a current / voltage converter (1010). out ) can be filtered through a filter (1020) to allow only frequencies of a specific band to pass through.

[0181] The frequency band used to measure glucose is mainly below about 10 Hz. The processor (1090) outputs the voltage (V) through a filter (1020). out) passes a predetermined frequency band (e.g., below about 10 Hz) and filters out the remaining frequency band.

[0182] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) can compensate for voltage to suit the conditions of a user performing glucose measurement (S1120). The processor (1090) obtains a gain value according to various factors such as external temperature and pressure, finger thickness of the subject, skin condition, skin color, and BMI (Body Mass Index) through a controller (1050), and reflects the gain value obtained through an amplifier (1030) to a frequency passing through a filter (1020) to compensate for voltage according to the amount of light.

[0183] And, the analog value output through the amplifier (1030) is transmitted to the analog / digital (Analog to Digital) converter (1040). For example, this gain value is or can be stored in the memory (1060).

[0184] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) can measure glucose by converting a compensated voltage value into a digital voltage value through an A / D converter (1040) (S1122). The processor (1090) can convert an analog input signal into a digital voltage value at a rate of 20 samples per second through the A / D converter (1040).

[0185] According to one embodiment, a non-invasive glucose measurement device (e.g., processor (1090)) can display information about measured glucose on an input / output unit (1080) (S1124). The processor (1090) can display information about glucose measured through a user's finger (901) on an input / output unit (e.g., display unit (130)).

[0186] Referring to FIG. 14, the processor (1090) can measure the transmittance information (e.g., DC component), temperature, and pressure in real time, and display the measured results in real time through an input / output unit (e.g., display unit (130)).

[0187] The above screen (1410) is an example of measuring glucose after a meal, and the processor (1090) may include information (1413) indicating the measurement time, a home menu (1411), a measurement start menu (1412), information (1415) indicating information related to the measurement, and information (1416) indicating the measurement progress rate.

[0188] Alternatively, the processor (1090) may output information about glucose measured through the user's finger (901) through an input / output unit (e.g., a speaker (1082)).

[0189] Referring to FIG. 15, when the process of measuring glucose through a finger is completed for a predetermined time, the processor (1090) can display a screen (1510) including information (1511) including a glucose measurement value through an input / output unit (e.g., a display unit (130)).

[0190] For example, the screen (1510) may include a save menu (1513) for saving measurement information (e.g., measurement time, measurement value (1511), etc.), and a cancel menu (1512) for canceling saving of measurement information.

[0191] For example, when a user selects a save menu (1513) to save measurement information, the processor (1090) can save the measurement information (e.g., measurement time, measurement value (1511), etc.) in the memory (1060).

[0192] Referring to FIG. 16, the processor (1090) can display a screen (1610) including accumulated data on glucose measured through a finger (901) through an input / output unit (e.g., a display unit (130)).

[0193] The above screen (1610) may include information about the measurement time (1611) (e.g., current time) and the number of measurements and measurement time at each measurement time (e.g., after waking up, before breakfast, after breakfast, before lunch, after lunch, before dinner, after dinner, before going to bed, etc.) (1612).

[0194] As described above, the non-invasive glucose measurement device (100) according to the present invention can measure glucose painlessly without collecting blood by irradiating light onto a finger and utilizing the amount of light transmitted through the finger.

[0195] FIG. 17 is a flowchart showing a process of measuring glucose by reflecting pressure from a finger measured by controlling a motor according to one embodiment of the present invention.

[0196] Hereinafter, with reference to FIG. 17, a process of measuring glucose by reflecting the pressure measured by a finger by controlling a motor according to one embodiment of the present invention will be described in detail as follows.

[0197] According to one embodiment, the processor (1090) can detect whether a finger is inserted into the inlet hole (210) of the non-invasive glucose measurement device (100) (S1710). The processor (1090) can determine whether a finger is inserted by identifying whether a finger is in contact with the inner lower case (320) (or whether a finger is pressing the inner lower case (320)) through at least one of the first pressure sensor (810) and the second pressure sensor (820).

[0198] According to one embodiment, the processor (1090) can drive the first motor and the second motor based on preset control values ​​(S1712). If the processor (1090) determines that a finger is inserted into the insertion hole (210), the processor (1090) can drive the first motor and the second motor based on the preset control values ​​(i.e., the initial values ​​for driving the motors).

[0199] According to one embodiment, the processor (1090) can measure a first pressure by a finger through a first pressure sensor (S1714). The processor (1090) can obtain a first pressure by which the finger presses the internal lower case (320) through the first pressure sensor (810). The first pressure sensor (810) can provide a value for the measured first pressure to the processor (1090).

[0200] According to one embodiment, the processor (1090) can measure a second pressure by a finger through a second pressure sensor (S1716). The processor (1090) can obtain a second pressure by which the finger presses the internal lower case (320) through the second pressure sensor (820). The second pressure sensor (820) can provide a value for the measured second pressure to the processor (1090).

[0201] According to one embodiment, the processor (1090) can compare the first pressure and the second pressure (S1718). The processor (1090) can compare the magnitude of the first pressure and the magnitude of the second pressure. The thickness, size, and shape of fingers may vary from person to person. Even when the thickness, size, and shape of the fingers are each varied, the non-invasive glucose measurement device of the present invention can accurately fix the finger by adjusting the height of the inner upper case (310) through the first motor unit (331) and the second motor unit (332). In addition, the non-invasive glucose measurement device of the present invention can uniformly (or similarly) apply the pressure that the finger (901) applies to the inner lower case (320) through the first motor unit (331) and the second motor unit (332).

[0202] According to one embodiment, the processor (1090) can identify whether the difference between the first pressure and the second pressure exceeds a threshold value (S1720). The processor (1090) can compare the difference between the first pressure value measured by the first pressure sensor (810) and the second pressure value measured by the second pressure sensor (820) with the size of the threshold value. The threshold value is a pressure value set to measure glucose more accurately by reflecting the pressure value by a finger when measuring glucose.

[0203] According to one embodiment, the processor (1090) determines that the finger (901) is applying pressure uniformly to the internal lower case (320) as the difference between the first pressure value and the second pressure value is smaller. Additionally, the processor (1090) determines that the finger (901) is not applying pressure uniformly to the internal lower case (320) as the difference between the first pressure value and the second pressure value is larger.

[0204] According to one embodiment, the processor (1090) may generate a motor control signal for at least one of the first motor and the second motor so that the difference between the first pressure and the second pressure is within a threshold value (S1722). If the difference exceeds the threshold value, the processor (1090) may generate a motor control signal to control the operation of at least one of the first motor unit (331) and the second motor unit (332) so that the difference is less than or equal to the threshold value.

[0205] In addition, the processor (1090) can generate a control signal to lower the inner upper case (310) when the difference exceeds the threshold value and to raise the inner upper case (310) by controlling a motor corresponding to a larger pressure value between the first pressure value and the second pressure value so that the difference does not exceed the threshold value.

[0206] According to one embodiment, the processor (1090) can control the operation of the motor by transmitting the generated motor control signal to the corresponding motor and measure the pressure by the finger (S1724). The processor (1090) can provide the generated motor control signal to at least one of the first motor unit (331) and the second motor unit (332), and adjust the height of the inner upper case (310) through at least one of the first motor unit (331) and the second motor unit (332). Thereafter, after the height of the inner upper case (310) is adjusted, the processor (1090) can measure the pressure.

[0207] According to one embodiment, the processor (1090) can measure glucose (S1726). When the motor operation is completed, the processor (1090) can measure pressure applied by a finger and then measure glucose through the process of FIG. 11.

[0208] Figure 18 is a flowchart illustrating a process for measuring glucose using different wavelengths according to an embodiment of the present invention. Figure 19 is an exemplary diagram illustrating absorption rates after different wavelengths have passed through a finger according to an embodiment of the present invention.

[0209] Hereinafter, with reference to FIG. 18, a process of measuring glucose using different wavelengths according to an embodiment of the present invention will be described in detail.

[0210] According to one embodiment, the processor (1090) can identify whether an input for glucose measurement is detected (S1810). The processor (1090) can detect the input for glucose measurement through the input / output unit (1080). The processor (1090) can receive various inputs for glucose measurement through the input / output unit (1080).

[0211] According to one embodiment, the processor (1090) can simultaneously irradiate a light beam of a first wavelength from a first light-emitting element and a light beam of a second wavelength different from the first wavelength from a second light-emitting element (S1812). The processor (1090) can irradiate a first light beam of a first wavelength (e.g., 600 nm to 800 nm) toward a finger (901) through a first light-emitting element of a first light-emitting unit (501), and irradiate a second light beam of a second wavelength (e.g., 800 nm to 1000 nm) having a different wavelength from the first wavelength (e.g., 600 nm to 800 nm) toward the finger (901) through a second light-emitting element of a second light-emitting unit (502).

[0212] For example, the first light irradiation unit (501) and the second light irradiation unit (502) can be sequentially arranged on the lower part of the inner lower case (320) in the direction in which the finger (901) is introduced into the introduction hole (210).

[0213] According to one embodiment, the processor (1090) can detect a first amount of light transmitted through the finger by a light beam of a first wavelength and a second amount of light transmitted through the finger by a light beam of a second wavelength (S1814). The first light-receiving element in the first light-receiving unit (911) can receive the light beam output from the first light-emitting element and transmitted through the finger (901), and the second light-receiving element in the second light-receiving unit (912) can receive the light beam output from the second light-emitting element and transmitted through the finger (901). The processor (1090) can obtain the first amount of light by the first light beam transmitted through the finger (901) through the first light-receiving element of the first light-receiving unit (911), and obtain the second amount of light by the second light beam transmitted through the finger (901) through the second light-receiving element of the second light-receiving unit (912).

[0214] Referring to FIG. 19, the first light-emitting element can irradiate light having a first wavelength (1901) (e.g., 600 nm to 800 nm), and the second light-emitting element can irradiate light having a second wavelength (1902) (e.g., 800 nm to 1000 nm). The range of the first wavelength (1901) and the range of the second wavelength (1902) are merely examples, and the present invention may include cases of various wavelengths. In addition, when light having different wavelengths passes through a finger, the absorption rate by the finger is also different.

[0215] For example, the absorption rate by the first wavelength (1901) (e.g., 600 nm to 800 nm) is 0.06 or less, and the absorption rate by the second wavelength (1902) (e.g., 800 nm to 1000 nm) is 0.06 to 0.25.

[0216] When measuring glucose, measurement errors may occur due to sensitivity to finger movement, changes in blood flow, and temperature changes. However, when measuring glucose simultaneously using two light-emitting elements with different wavelengths, measurements can be made under the same environmental conditions at the time of measurement using the two light-emitting elements, and when comparing each measurement data at that time, accurate deviation data can be obtained according to the consistency of environmental conditions.

[0217] According to one embodiment, the processor (1090) can calculate the ratio of the first light quantity and the second light quantity (S1816). The processor (1090) can calculate the ratio of the first light quantity and the second light quantity (e.g., the ratio of the second light quantity to the first light quantity) and reflect it in the light quantity obtained through the light receiving unit (911, 912). The processor (1090) can apply the difference in the light quantity detected by the first light receiving element and the second light receiving element as a calculated variable when calculating the glucose concentration through a data analysis algorithm, thereby improving the accuracy of glucose measurement.

[0218] In one embodiment, the processor (1090) may apply the calculated ratio as an output variable for measuring glucose (S1818). The processor (1090) may reflect the ratio as a variable for measuring glucose.

[0219] As described above, the present invention compares the difference between the first pressure value measured by the first pressure sensor and the second pressure value measured by the second pressure sensor with the size of a threshold value, and if the difference exceeds the threshold value, controls at least one of the first motor and the second motor so that the difference becomes less than the threshold value, thereby measuring the pressure and reflecting this in the glucose measurement, thereby enabling accurate glucose measurement.

[0220] In addition, the present invention can accurately measure pressure by controlling the motor to adjust the height of the inner upper case when the difference exceeds the threshold value.

[0221] Each step in each of the flowcharts described above may be performed regardless of the order shown, or may be performed simultaneously. Furthermore, at least one component of the present invention and at least one operation performed by said at least one component may be implemented in hardware and / or software.

[0222] Although the present invention has been described with reference to the drawings exemplified above, it is to be understood that the present invention is not limited to the embodiments and drawings disclosed herein, and that various modifications may be made by those skilled in the art within the scope of the technical idea of ​​the present invention. Furthermore, even if the operational effects according to the configuration of the present invention have not been explicitly described while describing the embodiments of the present invention, it is natural that the effects predictable by the corresponding configuration should also be acknowledged.

Claims

In a non-invasive glucose measuring device, A light emitting unit positioned at the lower portion of an internal lower case arranged at the lower portion of an inserted finger, the light emitting unit including a first light emitting element and a second light emitting element emitting light toward the finger mounted on the internal lower case; A light receiving unit disposed on the upper part of the inner upper case disposed on the upper part of the finger, the light receiving unit including a first light receiving element and a second light receiving element receiving light irradiated from the light irradiation unit and passing through the finger; A motor unit including a first motor arranged on one side of the inner lower case and a second motor arranged on the other side of the inner lower case; A pressure sensor unit including a first pressure sensor and a second pressure sensor arranged at the lower portion of the inner lower case and measuring the pressure applied by the finger; and A non-invasive glucose measurement device including a processor that measures glucose using the amount of light received through the light receiving unit. In the first paragraph, The above processor, Compare the difference between the first pressure value measured by the first pressure sensor and the second pressure value measured by the second pressure sensor and the size of the threshold value, If the difference exceeds the threshold value, the pressure is measured by controlling at least one of the first motor and the second motor so that the difference becomes less than or equal to the threshold value, A non-invasive glucose measuring device configured to measure glucose by reflecting the above measured pressure. In the first paragraph, A first adjusting member arranged on one side of the inner upper case to adjust the height of the inner upper case; and A non-invasive glucose measurement device comprising a second adjusting unit positioned on the other side of the inner upper case to adjust the height of the inner upper case. In the third paragraph, The above first control unit, A first gear that rotates by the power of the first motor; A first rack gear coupled to one side of the inner upper case and moving upward or downward by the rotation of the first gear; and A non-invasive glucose measurement device comprising a first rail guiding movement of the first rack gear. In the third paragraph, The above second control unit, A second gear that rotates by the power of the second motor; A second rack gear coupled to the other side of the inner upper case and moving upward or downward by the rotation of the second gear; and A non-invasive glucose measurement device further comprising a second rail for guiding movement of the second rack gear. In the first paragraph, A non-invasive glucose measurement device further comprising a top cover disposed between the inner upper case and the finger to closely support the finger. In the first paragraph, A first switch member disposed at the lower portion of the inner lower case and transmitting the pressure applied by the finger to the first pressure sensor; and A non-invasive glucose measurement device comprising a second switch member disposed at the lower portion of the inner lower case and transmitting the pressure by the finger to the second pressure sensor. In paragraph 7, The above first switch member is, A first protrusion formed on the upper surface of the first switch member so as to be inserted into the first hole formed in the inner lower case and to be in close contact with the finger; A second protrusion formed on the lower surface of the first switch member so as to be symmetrical with the first protrusion and in close contact with the first pressure sensor; and A non-invasive glucose measuring device comprising a spring disposed inside the first switch member, which moves the first switch member downward when pressed by the finger, and returns the first switch member to its original position when not pressed by the finger. In paragraph 7, The above second switch member is, A first protrusion formed on the upper surface of the second switch member so as to be inserted into a second hole formed in the inner lower case and to be in close contact with the finger; A second protrusion formed on the lower surface of the second switch member so as to be symmetrical with the first protrusion and in close contact with the second pressure sensor; and A non-invasive glucose measuring device comprising a spring disposed inside the second switch member, which moves the second switch member downward when pressed by the finger, and returns the second switch member to its original position when not pressed by the finger. In the second paragraph, The above processor, A non-invasive glucose measurement device configured to lower the inner upper case by controlling a motor corresponding to a smaller pressure value between the first pressure value and the second pressure value, and to raise the inner upper case by controlling a motor corresponding to a larger pressure value between the first pressure value and the second pressure value, when the difference exceeds the threshold value, so that the difference does not exceed the threshold value. In the second paragraph, The above processor, Outputting a first light beam of a first wavelength through the first light-emitting element, Outputting a second light beam of a second wavelength having a wavelength different from the first wavelength through the second light-emitting element, The first light quantity by the first light beam passing through the finger is obtained through the first light receiving element, A non-invasive glucose measuring device configured to obtain a second light quantity by the second light beam passing through the finger through the second light receiving element. In Article 11, The above processor, A non-invasive glucose measuring device set to calculate the ratio of the first light quantity and the second light quantity and reflect it in the light quantity obtained through the light receiving unit. In Article 12, A current / voltage converter that converts current to voltage for the light quantity if the difference does not exceed the threshold value; A filter that filters the frequency of the converted voltage into a predetermined frequency band; A controller that adjusts the gain value to correspond to the user's conditions for measuring glucose; An amplifier that amplifies the voltage by reflecting the adjusted gain value to the voltage of the filtered frequency; An A / D (Analog to Digital) converter that converts the amplified voltage value into a digital voltage value; and A non-invasive glucose measurement device further comprising a processor for measuring the user's glucose using the converted digital voltage value. In a method for measuring glucose in a noninvasive glucose measuring device, The above non-invasive glucose measuring device, A light emitting unit located at the lower part of an internal lower case arranged at the lower part of an inserted finger and including a first light emitting element and a second light emitting element for emitting light toward the finger seated in the internal lower case, a light receiving unit located at the upper part of an internal upper case arranged at the upper part of the finger and including a first light receiving element and a second light receiving element for receiving light irradiated from the light emitting element and passing through the finger, a motor unit including a first motor arranged at one side of the internal lower case and a second motor arranged at the other side of the internal lower case, and a pressure sensor unit located at the lower part of the internal lower case and including a first pressure sensor and a second pressure sensor for measuring pressure by the finger, The above method, A process of obtaining a first pressure value measured by the first pressure sensor and a second pressure value measured by the second pressure sensor; A process of comparing the difference between the first pressure value and the second pressure value and the size of the threshold value; A process of measuring pressure by controlling at least one of the first motor and the second motor so that the difference becomes less than or equal to the threshold value when the difference exceeds the threshold value; and A method comprising a process of measuring glucose by reflecting the measured pressure. In Article 14, The process of measuring pressure by controlling at least one of the first motor and the second motor is as follows: A method comprising the steps of controlling a motor corresponding to a smaller pressure value between the first pressure value and the second pressure value to lower the inner upper case, and controlling a motor corresponding to a larger pressure value between the first pressure value and the second pressure value to raise the inner upper case so that the difference does not exceed the threshold value. In Article 14, The process of measuring the above glucose is: If the above difference does not exceed the above threshold value, a process of converting the current for the amount of light obtained through the light receiving unit into voltage; A process of filtering the frequency of the converted voltage into a predetermined frequency band; The process of adjusting the gain value to correspond to the user's conditions for measuring glucose; A process of amplifying the voltage by reflecting the adjusted gain value to the voltage of the filtered frequency; A process of converting the amplified voltage value into a digital voltage value; and A method comprising a process of measuring the user's glucose using the converted digital voltage value.

Images