Composition capable of boosting throat hit, liquid formulation, preparation method therefor, and use thereof

Abstract

A composition capable of boosting throat hit, the composition comprising trigonelline, magnolol, piperonol and tropine. Specific substances are selected as raw material components of the composition capable of boosting throat hit, and, due to the synergistic effect thereof, the stimulation to the human brain can be significantly improved, and the satisfaction provided by zero-nicotine liquid formulations can be improved, thereby achieving the purpose of physiologically reduce the users' addiction. Further provided are a liquid formulation comprising the composition capable of boosting throat hit, a preparation method therefor, and the use thereof.

Description

A composition capable of enhancing strength, liquid preparation and preparation method and application thereof

[0001] Cross-reference to related applications

[0002] The present application claims priority to the Chinese patent application No. 202410830860.1, filed on June 25, 2024, and entitled "A composition capable of enhancing strength, liquid preparation and preparation method and application thereof", the entire contents of which are incorporated herein by reference. TECHNICAL FIELD

[0003] The present application relates to the technical field of electronic atomization, in particular to a composition capable of enhancing strength, liquid preparation and preparation method and application thereof. BACKGROUND

[0004] An electronic cigarette is a smokeless tobacco product that delivers nicotine without tobacco smoke. It can effectively reduce tobacco intake, just like nicotine replacement therapy. An electronic cigarette mainly consists of a cartridge, an atomizer and a power supply. The cartridge is a container device for holding nicotine liquid preparation. The main components of nicotine liquid preparation are nicotine, propylene glycol, glycerol, flavorings and spices. The atomizer is powered by a battery rod and can atomize the liquid nicotine in the cartridge into aerosol with a specific odor, thereby providing the user with a pleasant experience. In the composition of nicotine liquid preparation, nicotine mainly provides a sense of satisfaction. Nicotine (nicotine) is an acetylcholine receptor agonist that has a higher affinity for acetylcholine receptors than the body's own acetylcholine neurotransmitter. When a small amount of nicotine is ingested, it is equivalent to increasing the amount of acetylcholine neurotransmitter in the body, causing an increase in the amount of dopamine secreted by neurons in the body, resulting in a sense of pleasure, happiness and relaxation. However, if the amount of nicotine ingested is too high, it can cause vomiting and nausea, and in severe cases, death. In order to prevent the abuse of nicotine and protect public health and safety, countries have strict regulations on nicotine products, limiting the nicotine content to 20mg / g or less. Many countries have also implemented zero-nicotine electronic atomization devices. Zero-nicotine products do not have the problem of nicotine addiction. Currently, zero-nicotine liquid preparation products achieve the effect of satisfying and enhancing strength by adding a cooling agent to improve the cooling sensation of the throat, but the cooling sensation of the throat is different from the throat irritation caused by nicotine, resulting in a weak sense of satisfaction. This cannot provide consumers with a good sense of satisfaction and cannot achieve the physiological purpose of overcoming addiction. SUMMARY

[0005] The present application aims to overcome the weak sense of satisfaction of zero-nicotine atomization preparation in the prior art, and further provides a composition capable of enhancing strength, liquid preparation and preparation method and application thereof.

[0006] To achieve the above object, the application adopts the following technical scheme:

[0007] The application provides a strength-improving composition, which comprises trigonelline, magnolol, piperonyl alcohol and tropine alcohol.

[0008] Optionally, the mass ratio of the trigonelline, magnolol, piperonyl alcohol and tropine alcohol is (5-10):(1-5):(5-15):(1-5).

[0009] The application provides a liquid preparation, raw material components of the liquid preparation comprising strength-improving substances, throat-kicking substances and atomization solvents.

[0010] The strength-improving substances comprise the above-mentioned strength-improving composition.

[0011] The throat-kicking substances comprise piperine.

[0012] Optionally, the mass concentration of the strength-improving substances in the liquid preparation is 7-35 mg / g.

[0013] Optionally, the mass ratio of the throat-kicking substances and the strength-improving substances is (0.01-0.1):(7-35).

[0014] Optionally, the atomization solvents comprise at least one of propylene glycol and glycerol.

[0015] Optionally, the atomization solvents are propylene glycol and glycerol.

[0016] The mass ratio of the propylene glycol and the glycerol is (1-90):(1-90).

[0017] Optionally, the mass ratio of the atomization solvents and the strength-improving substances is (50-98.5):(0.7-3.5).

[0018] Optionally, the raw material components of the liquid preparation further comprise fragrances.

[0019] Optionally, the fragrances comprise at least one of tobacco fragrances, fruit fragrances and mint fragrances.

[0020] Optionally, the fruit fragrances comprise at least one of mango fragrances, blueberry fragrances and grape fragrances.

[0021] Optionally, the mass ratio of the strength-improving substances and the fragrances is (0.7-3.5):(20-50).

[0022] Optionally, the liquid preparation comprises trigonelline, magnolol, piperonyl alcohol, tropine alcohol, piperine, fragrances, propylene glycol and glycerol.

[0023] The mass ratio of the trigonelline, magnolol, piperonyl alcohol, tropine, piperine, essence, propylene glycol and glycerol is (5-10):(1-5):(5-15):(1-5):(0.01-0.1):(200-500):(0-1000):(0-1000);

[0024] Optionally, the mass ratio of the trigonelline, magnolol, piperonyl alcohol, tropine, piperine, essence, propylene glycol and glycerol is (5-10):(1-5):(5-15):(1-5):(0.01-0.1):(200-500):(1-1000):(1-1000).

[0025] The application provides a preparation method of the liquid preparation, comprising the following steps:

[0026] The strength substance, throat-kicking substance and atomizing solvent are mixed and heated and stirred to be uniform to obtain the liquid preparation.

[0027] Optionally, the preparation method of the liquid preparation further comprises the step of adding essence.

[0028] The liquid preparation provided by the application is used for improving satisfaction, and further, is used for improving the satisfaction of a user.

[0029] The stirring method is not limited in the application, and is optionally selected from mechanical stirring, mechanical oscillation or ultrasonic oscillation.

[0030] The application provides an electronic cigarette liquid, which comprises the strength-improving composition, the liquid preparation or the liquid preparation prepared by the preparation method.

[0031] The application provides an application of the strength-improving composition, the liquid preparation or the liquid preparation prepared by the preparation method in an atomizing device.

[0032] Optionally, the atomizing device is an electronic atomizing device.

[0033] The application has the following beneficial effects:

[0034] The strength-improving composition provided by the application comprises trigonelline, magnolol, piperonyl alcohol and tropine. The specific strength-improving composition provided by the application is trigonelline, magnolol, piperonyl alcohol and tropine, which can significantly improve the stimulation to the human brain and obtain obvious satisfaction in the synergistic effect. Therefore, the application selects specific substances as raw material components of the strength-improving composition, so that the satisfaction of the zero-nicotine liquid preparation is improved in the synergistic effect, thereby achieving the physiological purpose of the user's drug withdrawal. BRIEF DESCRIPTION OF DRAWINGS

[0035] In order to more clearly illustrate the technical solutions of the specific embodiments or prior art in the present application, the drawings required to be used in the description of the specific embodiments or prior art will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without any creative effort on the basis of these drawings.

[0036] Figure 1 is a graph of the average normalized heart rate of Example 2, Comparative Example 7, Comparative Example 8, Comparative Example 9 and Comparative Example 10 of the present application.

[0037] Figure 2 is a graph of the normalized heart rate of Example 2, Comparative Example 7, Comparative Example 8, Comparative Example 9 and Comparative Example 10 of the present application. DETAILED DESCRIPTION

[0038] The following examples are provided to better further understand the present application and are not limited to the best mode, and do not limit the content and protection scope of the present application. Any person who obtains any product identical or similar to the present application under the inspiration of the present application or by combining the present application with other prior art features falls within the protection scope of the present application.

[0039] The specific experimental steps or conditions are not specified in the examples, and can be performed according to the conventional experimental steps or conditions described in the literature in the art. The reagents or instruments used are not specified by the manufacturer, and are all conventional reagent products that can be obtained by purchase.

[0040] An electronic cigarette is a tobacco smoke-free delivery nicotine alternative product that delivers nicotine into the blood, like nicotine replacement therapy, which can effectively reduce tobacco intake. An electronic cigarette mainly consists of three parts: a cartridge, an atomizer, and a power supply. The cartridge is a container device for holding nicotine liquid preparation, the main components of which are nicotine, propylene glycol, glycerol, and flavoring agents. The atomizer is powered by a battery rod and can atomize the liquid nicotine in the cartridge into aerosol with a specific odor, thereby providing the user with a product to use. Among the components of the nicotine liquid preparation, nicotine mainly plays a role in providing satisfaction. Nicotine (i.e., nicotine) is an acetylcholine receptor agonist that has a higher affinity for acetylcholine receptors than the acetylcholine neurotransmitter secreted by the human body. When a small amount of nicotine is ingested, it is equivalent to increasing the amount of acetylcholine neurotransmitter in the human body, causing an increase in the amount of dopamine secreted by neurons in the human body, resulting in a feeling of pleasure, happiness, and relaxation. However, if the amount of nicotine ingested is too high, it can cause vomiting and nausea, and in severe cases, death. In order to prevent the abuse of nicotine and protect the health and safety of the public, countries have implemented strict regulations on nicotine products, limiting the nicotine content to 20 mg / g or less. Many countries have also implemented zero-nicotine electronic atomization devices. Zero-nicotine products do not have the problem of nicotine addiction. Currently, zero-nicotine liquid preparation products achieve the effect of satisfaction enhancement by adding a cooling agent and improving the throat cooling stimulation to achieve satisfaction enhancement. However, the throat stimulation of the cooling sensation is different from the throat stimulation of nicotine, making the product's satisfaction very weak and unable to make consumers physiologically quit.

[0041] The present application provides a composition that can enhance the kick, which includes trigonelline, magnolol, piperonal, and tropine alcohol.

[0042] Trigonelline is a plant alkaloid found in coffee, fenugreek seeds, and radish. Green coffee beans contain a large amount of trigonelline after roasting, and it is the main volatile substance in coffee and the main invigorating substance. Fenugreek extract is a new economic and efficient natural antioxidant resource. It has various physiological activities and is widely used in antibacterial, anticancer, antidiabetic, antihypertensive, and antihyperlipidemic related research. The inventors have unexpectedly found that trigonelline can significantly increase the levels of dopamine, norepinephrine, and 5-hydroxytryptamine, three neurotransmitters in the mouse brain, and has a similar effect to nicotine in promoting dopamine and norepinephrine release after nicotine intake. Therefore, trigonelline is a potential effective substance for simulating the kick of nicotine.

[0043] Piperine is a compound extracted from pepper, which is often used in health and nutrition products to enhance the body's absorption and utilization of nutrients. Oral piperine metabolizes in the body to produce various metabolites, including piperine, which selectively or non-selectively inhibits the activity of monoamine oxidase (MAO) in the body. Monoamine oxidase is an enzyme in the brain that regulates the inactivation pathways of various neurotransmitters, including norepinephrine, epinephrine, dopamine, and serotonin. Piperine metabolites containing piperine inhibit monoamine oxidase, reducing the inactivation rate of neurotransmitters such as dopamine and serotonin, which indirectly increases the amount of neurotransmitters such as dopamine and serotonin in the brain over the same period. Nicotine intake also significantly promotes the release of neurotransmitters such as dopamine and serotonin. Therefore, piperine is a potential substance that mimics the effects of nicotine.

[0044] Magnolol is an active ingredient in the extract of Magnolia officinalis, which has sedative, hypnotic, anti-anxiety, and anti-epileptic effects. Magnolol can counteract exogenous morphine and inhibit the release of endogenous enkephalins, thereby alleviating withdrawal symptoms. It also promotes the release of beta-endorphins and agonizes cannabinoid receptors, and counteracts the excitatory effects of central excitatory neurotransmitters glutamate and N-methyl-D-aspartate (NMDA) receptors.

[0045] Tropine is a compound found in Solanaceae herbaceous plants, and its main target in the brain is the M4 subtype of acetylcholine receptors, which produces an antagonistic effect without intrinsic activity. The M4 subtype of acetylcholine receptors is involved in the regulation of dopamine neurotransmitter release in the brain. In the dorsal striatum region of the brain, activation of M4 receptors produces a sustained inhibitory effect on dopamine neurotransmitter release. In contrast, the addition of M4 receptor antagonists can effectively block the activation effect of endogenous acetylcholine neurotransmitters on M4 receptors, thereby reducing the activity of interneurons (mainly output inhibitory effect) and further weakening the inhibitory effect on dopamine neurons near the interneurons, thereby increasing dopamine neurotransmitter release. Nicotine intake significantly promotes the release of dopamine neurotransmitters in the brain. Therefore, the intake of tropine can mimic the potential effects of nicotine.

[0046] The application provides a strength-improving composition, which comprises trigonelline, magnolol, piperonyl alcohol and tropine. The specific strength-improving composition of the application: trigonelline, magnolol, piperonyl alcohol and tropine can significantly improve the stimulation to human brain and make the brain produce similar strength effect to nicotine, so that obvious satisfaction is obtained. Therefore, the application selects specific substances as raw material components of the strength-improving composition, and the satisfaction of zero-nicotine liquid preparation is improved under the synergistic effect of the specific substances, so that the physiological addiction of the user is achieved. Meanwhile, the inventors find that the satisfaction-improving effect of the synergistic combination of trigonelline, magnolol, piperonyl alcohol and tropine is obviously better than the satisfaction-improving effect of the combination of any one of the substances or any two of the substances or any three of the substances.

[0047] Therefore, the application selects specific substances, i.e., trigonelline, magnolol, piperonyl alcohol and tropine, as raw material components of the strength-improving composition, and the strength experience of zero-nicotine liquid preparation is improved under the synergistic effect of the specific substances, so that the satisfaction of the user is improved, the physiological addiction is achieved, and the toxicity and addiction are reduced, and the health damage is reduced.

[0048] In some optional embodiments, the mass ratio of the trigonelline, magnolol, piperonyl alcohol and tropine is (5-10):(1-5):(5-15):(1-5), for example, the mass ratio of the trigonelline, magnolol, piperonyl alcohol and tropine can be selected as 5:1:5:1, 6:1:5:1, 7:1:5:1, 8:1:5:1, 9:1:5:1, 10:1:5:1, 5:2:5:1, 6:2:5:1, 7:2:5:1, 8:2:5:1, 9:2:5:1, 10:2:5:1, 5:3:5:1, 6:3:5:1, 7:3:5:1, 8:3:5:1, 9:3:5:1, 10:3:5:1, 5:4:5:1, 6:4:5:1, 7:4:5:1, 8:4:5:1, 9:4:5:1, 10:4:5:1, 5:5:5:1, 6:5:5:1, 7:5:5:1, 8:5:5:1, 9:5:5:1, 10:5:5:1, 5:1:6:1, 5:1:7:1, 5:1:8:1, 5:1:9:1, 5:1:10:1, 5:1:11:1, 5:1:12:1, 5:1:13:1, 5:1:14:1, 10:5:15:5, 10:5:15:1, 10:5:15:3, 10:5:5:5, 10:5:7:5, 10:5:10:5, 10:5:14:5, 10:5:13:5, 7:2:10:2, 7:2:15:2, 7:2:12:2, 7:2:7:2, 7:2:5:2, 7:2:9:2, 7:2:10:5.

[0049] The present application provides a liquid formulation, the raw material components of which include a kick substance, a throat hit substance, and an atomizing solvent; the kick substance includes the aforementioned kick-enhancing composition; the throat hit substance includes piperine. The inventors have found that compounding a specific kick-enhancing composition with a throat hit substance and an atomizing solvent into a liquid formulation with zero nicotine content can improve the satisfaction of the zero nicotine liquid formulation and make the consumer physiologically addicted.

[0050] In some optional embodiments, the throat hit substance includes piperine. Piperine is an alkaloid and is the source of the pungent flavor of pepper and the most important bioactive ingredient. Piperine is a modulator of human transient receptor potential (TRP) channels, similar to nicotine, and can bring people a throat feeling of pain, irritation, and tingling after activating TRP channels, forming a throat hit feeling and assisting in regulating the satisfaction of the user. In addition, piperine also inhibits enzymes that play an important role in the drug metabolism process. By inhibiting the drug metabolism process, piperine can improve the bioavailability of many compounds.

[0051] In some optional embodiments, the mass concentration of the kick substance in the liquid formulation is 7-35 mg / g. For example, the mass concentration of the kick substance in the liquid formulation can be selected as 7 mg / g, 8 mg / g, 9 mg / g, 10 mg / g, 11 mg / g, 12 mg / g, 13 mg / g, 14 mg / g, 15 mg / g, 16 mg / g, 17 mg / g, 18 mg / g, 19 mg / g, 20 mg / g, 21 mg / g, 22 mg / g, 23 mg / g, 24 mg / g, 25 mg / g, 26 mg / g, 27 mg / g, 28 mg / g, 29 mg / g, 30 mg / g, 31 mg / g, 32 mg / g, 33 mg / g, 34 mg / g, or 35 mg / g.

[0052] In some alternative embodiments, the throat-tingling substance and the kick substance are in a mass ratio of (0.01-0.1):(7-35). For example, the throat-tingling substance and the kick substance can be in a mass ratio of 0.01:7, 0.02:7, 0.03:7, 0.04:7, 0.05:7, 0.06:7, 0.07:7, 0.08:7, 0.09:7, 0.1:7, 0.01:9, 0.02:9, 0.03:9, 0.04:9, 0.05:9, 0.06:9, 0.07:9, 0.08:9, 0.09:9, 0.1:9, 0.01:10, 0.02:10, 0.03:10, 0.04:10, 0.05:10, 0.06:10, 0.07:10, 0.08:10, 0.09:10, 0.1:10, 0.01:12, 0.02:12, 0.03:12, 0.04:12, 0.05:12, 0.06:12, 0.07:12, 0.08:12, 0.09:12, 0.1:12, 0.01:15, 0.02:15, 0.03:15, 0.04:15, 0.05:15, 0.06:15, 0.07:15, 0.08:15, 0.09:15, 0.1:15, 0.01:18, 0.02:18, 0.03:18, 0.04:18, 0.05:18, 0.06:18, 0.07:18, 0.08:18, 0.09:18, 0.1:18, 0.01:20, 0.02:20, 0.03:20, 0.04:20, 0.05:20, 0.06:20, 0.07:20, 0.08:20, 0.09:20, 0.1:20, 0.01:23, 0.02:23, 0.03:23, 0.04:23, 0.05:23, 0.06:23, 0.07:23, 0.08:23, 0.09:23, 0.1:23, 0.01:25, 0.02:25, 0.03:25, 0.04:25, 0.05:25, 0.06:25, 0.07:25, 0.08:25, 0.09:25, 0.1:25, 0.01:28, 0.02:28, 0.03:28, 0.04:28, 0.05:28, 0.06:28, 0.07:28, 0.08:28, 0.09:28, 0.1:28, 0.01:30, 0.02:30, 0.03:30, 0.04:30, 0.05:30, 0.06:30, 0.07:30, 0.08:30, 0.09:30, 0.1:30, 0.01:33, 0.02:33, 0.03:33, 0.04:33, 0.05:33, 0.06:33, 0.07:33, 0.08:33, 0.09:33, 0.1:33, 0.01:35, 0.02:35, 0.03:35, 0.04:35, 0.05:35, 0.06:35, 0.07:35, 0.08:35, 0.09:35, 0.1:35.

[0053] In some alternative embodiments, the atomized solvent can be conventional atomized solvent in the art, including but not limited to at least one of propylene glycol, glycerol; alternatively, the mass ratio of the atomized solvent to the strength substance is (50-98.5):(0.7-3.5), for example, the mass ratio of the atomized solvent to the strength substance can be selected from 98.5:0.7, 98:0.7, 80:0.7, 90:0.7, 85:0.7, 70:0.7, 75:0.7, 60:0.7, 65:0.7, 50:0.7, 98.5:1, 98:1, 80:1, 90:1, 85:1, 70:1, 75:1, 60:1, 65:1, 50:1, 98.5:1.5, 98:1.5, 80:1.5, 90:1.5, 85:1.5, 70:1.5, 75:1.5, 60:1.5, 65:1.5, 50:1.5, 98.5:2, 98:2, 80:2, 90:2, 85:2, 70:2, 75:2, 60:2, 65:2, 50:2, 98.5:2.5, 98:2.5, 80:2.5, 90:2.5, 85:2.5, 70:2.5, 75:2.5, 60:2.5, 65:2.5, 50:2.5, 98.5:3, 98:3, 80:3, 90:3, 85:3, 70:3, 75:3, 60:3, 65:3, 50:3, 98.5:3.5, 98:3.5, 80:3.5, 90:3.5, 85:3.5, 70:3.5, 75:3.5, 60:3.5, 65:3.5, 50:3.5. Alternatively, the atomized solvent is propylene glycol and glycerol. The mass ratio of the propylene glycol and glycerol is (1-90):(1-90), for example, the mass ratio of the propylene glycol and glycerol can be selected from 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, 1:10, 10:1, 1:9, 9:1. The addition of the atomized solvent in the present application can better dissolve the raw material components, effectively improve the atomization efficiency of the strength substance, and increase the satisfaction.

[0054] In some alternative embodiments, the raw material components of the liquid preparation further comprise a flavoring. The flavoring can be a conventional existing flavoring material in the art, which can be obtained commercially or prepared by conventional components by conventional methods, for example, a monomer flavoring raw material or a plurality of extracts can be selected and mixed. The flavoring includes but is not limited to tobacco flavoring, fruit flavoring, and mint flavoring. Further, the fruit flavoring includes at least one of mango flavoring, blueberry flavoring, and grape flavoring. Optionally, the mass ratio of the strength substance to the flavoring is (0.7-3.5):(20-50), for example, the mass ratio of the strength substance to the flavoring can be 0.7:20, 0.9:20, 1:20, 1.2:20, 1.5:20, 1.85:20, 2:20, 2.2:20, 2.5:20, 2.8:20, 3:20, 3.3:20, 3.5:20, 0.7:25, 0.9:25, 1:25, 1.2:25, 1.5:25, 1.85:25, 2:25, 2.2:25, 2.5:25, 2.8:25, 3:25, 3.3:25, 3.5:25, 0.7:30, 0.9:30, 1:30, 1.2:30, 1.5:30, 1.85:30, 2:30, 2.2:30, 2.5:30, 2.8:30, 3:30, 3.3:30, 3.5:30, 0.7:35, 0.9:35, 1:35, 1.2:35, 1.5:35, 1.85:35, 2:35, 2.2:35, 2.5:35, 2.8:35, 3:35, 3.3:35, 3.5:35, 0.7:40, 0.9:40, 1:40, 1.2:40, 1.5:40, 1.85:40, 2:40, 2.2:40, 2.5:40, 2.8:40, 3:40, 3.3:40, 3.5:40, 0.7:45, 0.9:45, 1:45, 1.2:45, 1.5:45, 1.85:45, 2:45, 2.2:45, 2.5:45, 2.8:45, 3:45, 3.3:45, 3.5:45, 0.7:50, 0.9:50, 1:50, 1.2:50, 1.5:50, 1.85:50, 2:50, 2.2:50, 2.5:50, 2.8:50, 3:50, 3.3:50, 3.5:50.

[0055] In some alternative embodiments, the liquid preparation comprises trigonelline, magnolol, piperonyl alcohol, tropine, piperine, essence, propylene glycol and glycerol; the mass ratio of the trigonelline, magnolol, piperonyl alcohol, tropine, piperine, essence, propylene glycol and glycerol is (5-10):(1-5):(5-15):(1-5):(0.01-0.1):(200-500):(0-1000):(0-1000); alternatively, the mass ratio of the trigonelline, magnolol, piperonyl alcohol, tropine, piperine, essence, propylene glycol and glycerol is (5-10):(1-5):(5-15):(1-5):(0.01-0.1):(200-500):(1-1000):(1-1000).

[0056] The present application provides a preparation method of the above-mentioned liquid preparation, comprising the following steps: mixing the strength-improving substance, the throat-kicking substance and the atomizing solvent, and then heating and stirring to obtain the liquid preparation.

[0057] In some alternative embodiments, the preparation method of the liquid preparation further comprises the step of adding essence.

[0058] The present application does not specifically limit the heating and stirring temperature and time, as long as the raw materials can be dissolved. Alternatively, the dissolution temperature is not higher than 100°C. Alternatively, the heating and stirring temperature is 40-65°C, and the heating and stirring time is 20-30 min. The present application does not specifically limit the mixing method and order, and in the present application, all the raw materials can be mixed and then heated and dissolved, or part of the raw materials can be mixed and dissolved first, and then the remaining raw materials are mixed and dissolved.

[0059] In some alternative embodiments, the preparation method of the liquid preparation comprises the following steps: mixing the strength-improving substance, the throat-kicking substance and the atomizing solvent, heating at 40-65°C for 20-30 min to dissolve and mix uniformly, cooling to 10-35°C, adding essence and stirring for 5-40 min to mix uniformly, to obtain the liquid preparation.

[0060] The present application provides an electronic cigarette liquid, and the raw material components thereof comprise the above-mentioned strength-improving composition, the above-mentioned liquid preparation or the liquid preparation prepared by the above-mentioned preparation method.

[0061] The present application provides the use of the above-mentioned strength-improving composition, the above-mentioned liquid preparation or the liquid preparation prepared by the above-mentioned preparation method in an atomizing device. Alternatively, the atomizing device is an electronic atomizing device.

[0062] The present application will be further described in detail in combination with specific examples, which cannot be understood as limiting the scope of the present application.

[0063] Example 1

[0064] The present example provides a preparation method of a liquid preparation, comprising the following steps:

[0065] Mix 1.0 g trigonelline, 0.5 g magnolol, 1.5 g piperonyl alcohol, 0.5 g tropine, 0.004 g piperine, 11.496 g propylene glycol and 40 g glycerol, heat and stir in a water bath at 60°C for 20 min to mix uniformly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix uniformly, to obtain the liquid preparation.

[0066] Example 2

[0067] The present example provides a preparation method of a liquid preparation, comprising the following steps:

[0068] Mix 0.5 g trigonelline, 0.1 g magnolol, 0.5 g piperonyl alcohol, 0.1 g tropine, 0.004 g piperine, 13.796 g propylene glycol and 40 g glycerol, heat and stir in a water bath at 60°C for 20 min to mix uniformly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix uniformly, to obtain the liquid preparation.

[0069] Example 3

[0070] The present example provides a preparation method of a liquid preparation, comprising the following steps:

[0071] Mix 0.7 g trigonelline, 0.2 g magnolol, 1.0 g piperonyl alcohol, 0.2 g tropine, 0.004 g piperine, 12.896 g propylene glycol and 40 g glycerol, heat and stir in a water bath at 60°C for 20 min to mix uniformly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix uniformly, to obtain the liquid preparation.

[0072] Example 4

[0073] The present example provides a preparation method of a liquid preparation, comprising the following steps:

[0074] Mix 1.0 g trigonelline, 0.5 g magnolol, 1.5 g piperonyl alcohol, 0.5 g tropine, 0.001 g piperine, 11.499 g propylene glycol and 40 g glycerol, heat and stir in a water bath at 60°C for 20 min to mix uniformly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix uniformly, to obtain the liquid preparation.

[0075] Example 5

[0076] The present embodiment provides a preparation method of a liquid preparation, comprising the following steps:

[0077] 1.0 g trigonelline, 0.5 g magnolol, 1.5 g piperonyl alcohol, 0.5 g tropine, 0.01 g piperine, 11.49 g propylene glycol and 40 g glycerol are mixed, heated and stirred in a water bath at 60°C for 20 min to make them uniformly mixed, 45 g blueberry essence is added after cooling to room temperature, and the mixture is uniformly mixed by continuing to stir for 20 min to obtain the liquid preparation.

[0078] Comparative Example 1

[0079] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0080] 15 g propylene glycol and 40 g glycerol are mixed, heated and stirred in a water bath at 60°C for 20 min to make them uniformly mixed, 45 g blueberry essence is added after cooling to room temperature, and the mixture is uniformly mixed by continuing to stir for 20 min to obtain the liquid preparation.

[0081] Comparative Example 2

[0082] The present comparative example provides a preparation method of a nicotine liquid preparation, comprising the following steps:

[0083] 0.9 g nicotine, 0.68 g benzoic acid, 13.42 g propylene glycol and 40 g glycerol are mixed, heated and stirred in a water bath at 60°C for 20 min to make them uniformly mixed, 45 g blueberry essence is added after cooling to room temperature, and the mixture is uniformly mixed by continuing to stir for 20 min to obtain the nicotine liquid preparation.

[0084] Comparative Example 3

[0085] The present comparative example provides a preparation method of a nicotine liquid preparation, comprising the following steps:

[0086] 1.36 g nicotine, 1.02 g benzoic acid, 12.62 g propylene glycol and 40 g glycerol are mixed, heated and stirred in a water bath at 60°C for 20 min to make them uniformly mixed, 45 g blueberry essence is added after cooling to room temperature, and the mixture is uniformly mixed by continuing to stir for 20 min to obtain the nicotine liquid preparation.

[0087] Comparative Example 4

[0088] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0089] Mix 0.7 g trigonelline, 0.5 g safrole, 0.004 g piperine, 13.796 g propylene glycol and 40 g of glycerol, heat and stir in a water bath at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix evenly, to obtain the liquid preparation.

[0090] Comparative Example 5

[0091] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0092] Mix 0.7 g trigonelline, 0.5 g piperonyl alcohol, 0.004 g piperine, 13.796 g propylene glycol and 40 g of glycerol, heat and stir in a water bath at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix evenly, to obtain the liquid preparation.

[0093] Comparative Example 6

[0094] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0095] Mix 0.7 g trigonelline, 0.5 g piperonyl alcohol, 0.004 g piperine, 13.796 g propylene glycol and 40 g of glycerol, heat and stir in a water bath at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix evenly, to obtain the liquid preparation.

[0096] Comparative Example 7

[0097] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0098] Mix 0.7 g trigonelline, 0.5 g piperonyl alcohol, 0.004 g piperine, 13.796 g propylene glycol and 40 g of glycerol, heat and stir in a water bath at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix evenly, to obtain the liquid preparation.

[0099] Comparative Example 8

[0100] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0101] Mix 0.7 g trigonelline, 0.5 g piperonyl alcohol, 0.004 g piperine, 13.796 g propylene glycol and 40 g of glycerol, heat and stir in a water bath at 60 °C for 20 min to mix evenly, after cooling to room temperature, add 45 g blueberry essence, continue to stir for 20 min to mix evenly, to obtain the liquid preparation.

[0102] Comparative Example 9

[0103] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0104] 0.5 g of trigonelline, 0.2 g of magnolol, 0.5 g of tropine, 0.004 g of piperine, 13.796 g of propylene glycol and 40 g of glycerol were mixed, heated and stirred in a water bath at 60°C for 20 min to make them uniformly mixed, 45 g of blueberry flavor was added after cooling to room temperature, and the mixture was continuously stirred for 20 min to make it uniformly mixed, thereby obtaining the liquid preparation.

[0105] Comparative Example 10

[0106] The present comparative example provides a preparation method of a liquid preparation, comprising the following steps:

[0107] 0.5 g of trigonelline, 0.2 g of magnolol, 0.5 g of tropine, 0.004 g of piperine, 13.796 g of propylene glycol and 40 g of glycerol were mixed, heated and stirred in a water bath at 60°C for 20 min to make them uniformly mixed, 45 g of blueberry flavor was added after cooling to room temperature, and the mixture was continuously stirred for 20 min to make it uniformly mixed, thereby obtaining the liquid preparation.

[0108] Test Example 1

[0109] The present application scores various sensory indicators of the liquid preparations of Examples 1-5 and Comparative Examples 1-10 by a subjective sensory method. The sensory team has 12 people, all of whom have more than 5 years of experience in smoking traditional cigarettes or electronic cigarettes, and nicotine abstinence is performed 12 h before sensory evaluation.

[0110] Each person has a sensory evaluation form, and the liquid preparations of different examples and comparative examples are evaluated by blind scoring. The sensory method is as follows: different examples and comparative examples are randomly coded by 3-digit numbers, the sensory personnel perform nicotine abstinence for 10 h the night before the sensory test, and the sensory test is performed at 10 am on the test day. Electronic cigarette appliances are used with different examples and comparative example samples, a total of 8 puffs of smoke (3 s for each puff, 27 s interval between puffs), the smoke is slightly retained in the oral cavity, and then swallowed into the lungs. The sensory personnel cannot communicate their sensory experience, and each person scores and evaluates according to the evaluation indicators in Table 1. After the sensory test of one sample, the sensory test of the next sample is performed after 2 h of abstinence. The sensory test results are shown in Table 2 (the score in Table 2 is the average score).

[0111] Table 1 Evaluation indicators

[0112] Table 2 Sensory score data

[0113] Test Example 2

[0114] The liquid preparation prepared in Example 2, Comparative Example 7, Comparative Example 8, Comparative Example 9 and Comparative Example 10 (hereinafter referred to as samples) were subjected to a puffing process heart rate test, and the test method was as follows: the person puffing nicotine was subjected to nicotine withdrawal the night before the puffing test, and the puffing process heart rate test was performed at 9 am on the day of the puffing test. Before puffing, the heart rate test instrument was worn (the heart rate test instrument was Leepu Xianbao ER1), and the real-time changes in heart rate were monitored throughout the entire puffing process. After the heart rate instrument was adjusted, when the heart rate was stable, a 2-minute baseline heart rate test was performed. Then the heart rate monitoring during the puffing process was started, and RELX5 generation of cigarette rods (with samples of different examples and comparative examples) were used, a total of 5 puffs of smoke (3s for each puff, and a 27s interval between adjacent two puffs), the total puffing time was about 2.5 min, and the time of starting each puff of smoke was recorded. After puffing, the heart rate change was monitored for another 1 min, and then the experiment was ended. After the end of one sample, 2 hours of withdrawal were performed, and then the puffing process heart rate test of the next sample was performed. The test results are shown in Figures 1 and 2, wherein the average normalized heart rate of Figure 1 is the ratio of the average monitoring heart rate during the puffing process to the average baseline heart rate in the above-mentioned 2 minutes, and the normalized heart rate of Figure 2 is the ratio of the real-time monitoring heart rate during the puffing process to the average baseline heart rate in the above-mentioned 2 minutes.

[0115] According to Figure 2, the normalized heart rate during the puffing process of the sample of Example 2 was obviously higher than that of the samples of Comparative Examples 7, 8, 9 and 10 at the 3rd, 4th and 5th puffs; and Figure 1 shows that the average normalized heart rate during the puffing process of the sample of Example 2 was obviously higher than that of the samples of Comparative Examples 7, 8, 9 and 10.

[0116] Obviously, the above examples are only examples for the purpose of clear illustration, and are not limitations on the embodiments. Based on the above description, other different forms of changes or variations can also be made by those of ordinary skill in the art. It is not necessary and impossible to exhaust all embodiments. The obvious changes or variations derived therefrom are still within the protection scope of the present application.

Claims

1. A composition for enhancing energy, characterized in that, The energy-boosting composition includes trigonelline, magnolol, piperine, and tropine.

2. The power-enhancing composition according to claim 1, characterized in that, The mass ratio of trigonelline, magnolol, piperine and tropine is (5-10):(1-5):(5-15):(1-5).

3. A liquid formulation, characterized in that, The raw material components of the liquid formulation include a stimulant, a throat-scratching agent, and an atomizing solvent; The power-enhancing substance includes the power-enhancing composition according to claim 1 or 2; The throat-punching substance includes piperine.

4. The liquid formulation according to claim 3, characterized in that, The concentration of the active ingredient in the liquid formulation is 7-35 mg / g.

5. The liquid formulation according to claim 3 or 4, characterized in that, The mass ratio of the throat-throating substance to the strength substance is (0.01-0.1):(7-35).

6. The liquid formulation according to any one of claims 3-5, characterized in that, The atomizing solvent includes at least one of propylene glycol and glycerol.

7. The liquid formulation according to any one of claims 3-6, characterized in that, The atomizing solvent is propylene glycol and glycerol; The mass ratio of propylene glycol to glycerol is (1-90):(1-90).

8. The liquid formulation according to any one of claims 3-7, characterized in that, The mass ratio of the atomizing solvent to the driving substance is (50-98.5):(0.7-3.5).

9. The liquid formulation according to any one of claims 3-8, characterized in that, The raw material components of the liquid preparation also include flavorings.

10. The liquid formulation according to claim 9, characterized in that, The flavoring includes at least one of tobacco flavoring, fruit flavoring, and mint flavoring; Optionally, the fruit flavoring includes at least one of mango flavoring, blueberry flavoring, and grape flavoring.

11. The liquid formulation according to claim 9 or 10, characterized in that, The mass ratio of the active ingredient to the flavoring is (0.7-3.5):(20-50).

12. The liquid formulation according to any one of claims 3-11, characterized in that, The liquid formulation includes trigonelline, magnolol, piperine, tropine, piperine, flavoring, propylene glycol, and glycerol; The mass ratio of trigonelline, magnolol, piperine, tropine, piperine, flavoring, propylene glycol and glycerol is (5-10):(1-5):(5-15):(1-5):(0.01-0.1):(200-500):(0-1000):(0-1000).

13. The liquid formulation according to any one of claims 3-12, characterized in that, The mass ratio of trigonelline, magnolol, piperine, tropine, piperine, flavoring, propylene glycol and glycerol is (5-10):(1-5):(5-15):(1-5):(0.01-0.1):(200-500):(1-1000):(1-1000).

14. A method for preparing a liquid formulation according to any one of claims 3-13, characterized in that, Includes the following steps: The product is obtained by mixing the stimulant, the throat hit agent, and the atomizing solvent, then heating and stirring until homogeneous.

15. The method for preparing the liquid formulation according to claim 14, characterized in that, It also includes the step of adding flavoring.

16. An electronic cigarette e-liquid, characterized in that, Its raw material components include the energy-boosting composition according to claim 1 or 2, the liquid formulation according to any one of claims 3-13, or the liquid formulation prepared by the preparation method according to claim 14 or 15.

17. The use of the boosting composition according to claim 1 or 2, the liquid formulation according to any one of claims 3-13, or the liquid formulation prepared by the preparation method according to claim 14 or 15 in an atomizing device.

18. The application according to claim 17, characterized in that, The atomizing device is an electronic atomizing device.

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