Composition for mineral replenishment and composition for preventing / improving mineral deficiencies

Abstract

The present invention addresses the problem of providing a material that can be ingested daily and can replenish minerals. A composition for mineral replenishment that solves this problem is characterized by containing silkworm powder.

Description

Composition for mineral supplementation and composition for preventing and improving mineral deficiency

[0001] The present invention relates to a composition for replenishing minerals and a composition for preventing and improving mineral deficiency.

[0002] Minerals are closely related to various physiological functions and metabolic regulation, and are essential nutrients for biological regulation. Minerals include macrominerals such as sodium, potassium, and calcium, as well as trace minerals such as iron, zinc, copper, and manganese. All of these must be replenished from the body, and intake standards for each have been established. When a mineral is deficient, specific deficiency symptoms appear.

[0003] For example, zinc is required for the activation of numerous enzymes and has a wide range of physiological functions, including skin metabolism, reproductive function, skeletal development, maintenance of taste, mental and behavioral effects, immune function, etc. Zinc deficiency can cause symptoms such as taste disorders, dermatitis and alopecia, chronic diarrhea, hypoalbuminemia, pancytopenia, immune dysfunction, neurosensory disorders, cognitive dysfunction, growth retardation, and gonadal development disorders (Non-Patent Document 1).

[0004] If you are deficient in zinc, it is recommended that you consume foods high in zinc, such as oysters and dried sardines, but if dietary zinc intake is insufficient, drug therapy with zinc preparations such as zinc acetate will be necessary. However, as mentioned above, zinc is involved in various physiological functions, so it is desirable to replenish the necessary amount of zinc by consuming it daily.

[0005] Guidelines for the Treatment of Zinc Deficiency 2018, Japanese Society of Clinical Nutrition, Journal of the Japanese Society of Clinical Nutrition, Vol. 40, No. 2

[0006] An object of the present invention is to provide a material that can be taken daily to replenish minerals.

[0007] As a result of intensive research to solve the above problems, the inventors discovered that silkworm powder contains minerals such as zinc and iron, and that when ingested, it has superior digestion and absorption efficiency compared to plant minerals, etc., and thus completed the present invention.

[0008] That is, the present invention includes the following aspects.

[0009] [1] A mineral supplement composition containing silkworm powder. [2] The mineral supplement composition of [1], wherein the mineral is one or more selected from the group consisting of zinc, iron, magnesium, and calcium. [3] A composition for preventing and improving mineral deficiency, containing silkworm powder. [4] The composition for preventing and improving mineral deficiency according to [3], wherein the mineral is zinc. [5] The composition for preventing and improving mineral deficiency according to [3] or [4], which is used so that 28 to 85 mg of zinc is orally administered per day to an adult or a child weighing 30 kg or more.

[0010] The composition of the present invention has high mineral digestion and absorption efficiency (bioavailability), and by taking it daily, it is possible to replenish the necessary amount of minerals and prevent and improve mineral deficiency.

[0011] The mineral supplement composition and the mineral deficiency prevention / amelioration composition of the present invention contain silkworm powder.

[0012] The silkworm powder used in the present invention is obtained by drying and powdering silkworms. The growth stage of the silkworms used as the raw material is not particularly limited, and any of larvae, pupae, and adults may be used, with larvae being preferred. Examples of methods for producing silkworm powder include those described in JP-A-08-337530, which describes a method in which fourth- to fifth-instar silkworms, at the end of their most mature stage, are subjected to an antioxidant treatment using nitrogen gas, followed by freeze-drying and powdering. Commercially available products include MorSilk (registered trademark) Powder (Morus Corporation).

[0013] Silkworm powder contains minerals such as zinc, iron, calcium, and magnesium, and because it has superior digestion and absorption efficiency compared to plant minerals, ingesting silkworm powder can replenish necessary amounts of minerals. Of these minerals, zinc and iron are preferred from the viewpoint of digestion and absorption efficiency, etc.

[0014] The following is an example of the mineral composition measured in silkworm powder: Zinc 4.6-6.42 mg / kg, Iron 3.21 mg / kg, Magnesium 269-364 mg / kg

[0015] The mineral supplement composition of the present invention may be silkworm powder itself, or it may be formulated with known food additives and / or food ingredients to form a food or beverage. The method of preparation is not particularly limited and can be conventional, and the form is not particularly limited. Examples include protein bars, protein powders, starch-based foods such as bread, biscuits, pancakes, noodles, and tablet candy; confectioneries such as gum, candy, and Japanese sweets; meat foods such as ham and sausage; fish foods such as chikuwa (fish cake) and kamaboko (fish paste); seafood foods; condiments such as dressings, soy sauce, jam, and furikake (rice topping); protein drinks; tea, juice, soft drinks, and alcoholic beverages. Combining the silkworm powder with matcha powder is particularly preferred, resulting in a food or beverage with an excellent flavor. Foods and beverages include foods for specified health uses, functional foods, and dietary supplements that have been approved or notified for mineral supplementation or for preventing or improving mineral deficiency.

[0016] The mineral supplement composition of the present invention can be in the form of feed or pet food, and is prepared according to a conventional method by appropriately blending silkworm powder with known feed ingredients, gelling agents, shape-retaining agents, pH adjusters, seasonings, preservatives, nutritional supplements, etc. The form is not particularly limited, and any form such as pellets, flakes, or mash may be used, and it can be used, for example, as feed for livestock such as cows, pigs, chickens, sheep, and horses, pet food for dogs and cats, and aquatic feed for fish and shellfish.

[0017] The composition for preventing and improving mineral deficiency of the present invention can be formulated by combining the silkworm powder with a pharmaceutically acceptable carrier, if necessary. Examples of pharmaceutically acceptable carriers include glucose, lactose, starch, mannitol, dextrin, fatty acid glycerides, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid esters, amino acids, gelatin, albumin, water, and physiological saline. Furthermore, conventional additives such as stabilizers, humectants, emulsifiers, binders, isotonicity agents, and excipients can be added as needed. The formulation is not particularly limited, and examples include liquids, powders, granules, capsules, and tablets, and can be prepared according to conventional methods.

[0018] The composition for preventing and improving mineral deficiency of the present invention can be applied to mammals, including humans, such as humans, dogs, cats, cows, pigs, chickens, sheep, and horses, with humans being the preferred treatment. While the dosage is not particularly limited, the higher digestion and absorption efficiency compared to conventional mineral preparations allows for lower mineral dosages. For example, in the case of zinc, zinc acetate preparations are typically administered at a daily dose of 50-150 mg of zinc to adults or children weighing 30 kg or more. The present invention exhibits a higher digestion and absorption efficiency, preferably at least about 1.2 times, more preferably at least about 1.75 times, compared to such zinc preparations. Therefore, the lower limit of the dosage is preferably 42 mg or more, more preferably 28 mg or more, and the upper limit is preferably 125 mg or less, more preferably 85 mg or less. Even at such low dosages, the same amount of zinc as that obtained with zinc preparations can be absorbed into the body. The dosage frequency may be, for example, once a day or in multiple divided doses. The administration interval may be, for example, daily or every few days.

[0019] Ingestion of the composition for preventing and improving mineral deficiency of the present invention in this way can replenish minerals and prevent or improve symptoms caused by insufficient mineral intake, such as taste disorders, dermatitis, alopecia, chronic diarrhea, hypoalbuminemia, pancytopenia, immune dysfunction, neurosensory disorders, cognitive dysfunction, growth retardation, and gonadal development disorders caused by iron deficiency, as well as decreased motor and cognitive functions and decreased immune function.

[0020] The mineral supplement composition and the composition for preventing and ameliorating mineral deficiency of the present invention may be labeled, for example, to the effect that it is used for mineral supplementation, to the effect that it is used to prevent and ameliorate mineral deficiency, or to the effect that it is used to prevent and ameliorate hypozincemia due to zinc binding, taste disorders, dermatitis / hair loss, chronic diarrhea, hypoalbuminemia, pancytopenia, immune dysfunction, neurosensory disorders, cognitive dysfunction, growth retardation, gonadal development disorders, anemia due to iron deficiency, decreased motor function / cognitive function, decreased immune function, etc. "Labeled" includes being labeled on the body, container, packaging, etc. of a product containing the composition of the present invention, being labeled on documents such as instructions, package inserts, pamphlets, and other printed materials disclosing product information, and being labeled on various leaflets, advertisements used for promotion including over the Internet, etc.

[0021] The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples in any way.

[0022] Example 1 Zinc Administration Test: The zinc administration test was conducted using a method established at the University of Illinois (USA) (Wedekind KJ and Baker DH. Zinc bioavailability in feed-grade sources of zinc. Journal of Animal Science, Volume 68, Issue 3, March 1990, pp. 684-689). This method involves measuring dietary zinc uptake into the tibia of chicks and comparing it with zinc sulfate, which is set at 100%. Specifically, the zinc administration test was conducted as follows.

[0023] <Experimental Animals> Male Ross-308; 8-day mean initial body weight: 107.0 g <Study Design> CRD; 9T x 7R x 5C; 13-day assay <Basal Diet Components> (%) Soybean concentrate (CP 63.9%) 31.00 Dextrose 28.955 Corn starch 28.96 Soybean oil 5.00 Zinc-free glycerol salt 5.37 DL-methionine 0.20 L-threonine 0.10 Purified vitamin mix 0.20 Choline chloride (99%) 0.20 DL-tocopheryl acetate 0.002 Ethoxyquin 0.0125 <Zinc Source> Silkworm powder (MorSilk® Powder; Morus Corporation), defatted soybean meal (SBM), and mulberry leaves were added in place of corn starch and / or dextrose. Analysis confirmed that the zinc contents of silkworm powder, defatted soybean meal, and mulberry leaves were 57 mg / kg, 71 mg / kg, and 29.7 mg / kg, respectively. Treatment design: 1. (Zinc deficiency) Basal diet 2.1 + 4 mg / kg zinc sulfate 3.1 + 8 mg / kg zinc sulfate 4.1 + 4 mg / kg silkworm powder 5.1 + 8 mg / kg silkworm powder 6.1 + 5 mg / kg defatted soybean meal 7.1 + 10 mg / kg defatted soybean meal 8.1 + 4 mg / kg mulberry leaves 9.1 + 8 mg / kg mulberry leaves

[0024] <Results> The following are the weight gain per chick (g; Table 1), feed intake per chick (g; Table 2), weight gain per kg of feed (g; Table 3), dry bone weight per tibia (mg; Table 4), bone ash (mg; Table 5), bone ash (%, Table 6), zinc intake (mg; Table 7), tibia ash zinc concentration per g of bone ash (μg; Table 8), and total tibia zinc per tibia (μg; Table 9) for days 8 to 21 of rearing.

[0025]

[0026] <Regression Analysis> (1) A multiple linear regression analysis using weight gain (g) as the objective parameter and regressing it on zinc intake (mg) was as follows:

[0027] (2) Multiple linear regression analysis using total tibia zinc (μg zinc / tibia) as the objective parameter and regressing on zinc intake (mg) gave the following results:

[0028] Thus, it was confirmed that silkworm powder is relatively more efficient at digesting and absorbing minerals than zinc sulfate and mulberry leaves.

[0029] The composition of the present invention has high efficiency of digestion and absorption of minerals and can be used as a food, drink or pharmaceutical product.

Claims

1. A mineral supplement composition containing silkworm powder.

2. The mineral supplement composition according to claim 1, wherein the mineral is one or more minerals selected from the group consisting of zinc, iron, magnesium and calcium.

3. A composition containing silkworm powder for preventing and improving mineral deficiency.

4. A composition for preventing and improving mineral deficiency according to claim 3, wherein the mineral is zinc.

5. The composition for preventing and improving mineral deficiency according to claim 4, which is administered orally in a daily dose of 28 to 85 mg of zinc to an adult or a child weighing 30 kg or more.

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