Process for preparing dipeptide compounds
Efficient synthesis of dipeptide intermediates is achieved through processes using hydrogenating agents and continuous reactors, addressing the challenges of peptide synthesis economics and scalability.
Patent Information
- Application Number
- PCT/US2025/036598
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2025-07-01
- Filing Date
- 2025-07-07
- Publication Date
- 2026-01-15
AI Technical Summary
The practicality and economics of chemical synthesis of peptides present significant challenges, particularly in the efficient production of dipeptide compounds that serve as intermediates for further peptide synthesis.
A series of processes involving specific reactants, catalysts, and reactors are employed to synthesize dipeptide compounds, including the use of hydrogenating agents like H2 and palladium on carbon catalysts, and continuous reaction systems such as flow reactors, to efficiently produce dipeptide intermediates like isopropyl ((2S,3S)-3-(2-(tert-butoxy)-2-oxoethoxy)pyrrolidine-2-carbonyl)-L-threoninate.
These processes provide efficient and scalable routes to dipeptide compounds, reducing catalyst usage and production costs while improving yield and selectivity, making them suitable for large-scale production.
Smart Images
Figure US2025036598_15012026_PF_FP_ABST