Multi-functional controlled release tablet compositions with enhanced stability and potency and environmental impact tracking
The controlled-release tablet composition addresses degradation issues in conventional products by using specific acid-base combinations and environmental tracking, achieving enhanced stability, potency, and multi-functional performance with reduced environmental impact.
Patent Information
- Application Number
- PCT/IB2025/057094
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-07-13
- Filing Date
- 2025-07-14
- Publication Date
- 2026-01-22
AI Technical Summary
Conventional liquid and effervescent tablet formulations in personal, home, and fabric care products suffer from degradation of active ingredients due to oxidation and hydrolysis, leading to reduced performance and increased environmental impact, while effervescent tablets lack adequate cleaning performance, multi-functionality, and safety, and often clog dispensers.
A controlled-release tablet composition comprising an effervescent agent, water-soluble active agents, a carrier molecule, and rheology modifier, with specific acid-base combinations for broad pH adjustability, and environmental impact tracking using blockchain or QR code technology.
Enhances stability and potency of active ingredients, provides efficient cleaning and multi-functional performance, prevents dispenser clogging, and reduces environmental footprint through real-time sustainability tracking.
Smart Images

Figure IMGF000025_0001 
Figure IMGF000026_0001 
Figure IMGF000027_0001
Abstract
Description
[0001] MULTI-FUNCTIONAL CONTROLLED RELEASE TABLET COMPOSITIONS WITH ENHANCED STABILITY AND POTENCY AND ENVIRONMENTAL IMPACT TRACKING
[0002] FIELD
[0003] The present disclosure relates to personal, home, office, workplace and fabric care products. Particularly, the present disclosure relates to multi-functional controlled-release tablet compositions for consumer products.
[0004] DEFINITION
[0005] As used in the present disclosure, the following term is generally intended to have the meaning as set forth below, except to the extent that the context in which it is used, indicates otherwise.
[0006] Molar substitution: The term “molar substitution” refers to the average number of substituent groups such as hydroxyalkyl group and the like, attached to each repeating unit in a polymer. It is a key parameter that influences properties such as solubility, stability, pharmacological action and the like of the modified polymer.
[0007] BACKGROUND
[0008] The background information herein below relates to the present disclosure but is not necessarily prior art.
[0009] Traditional liquid formats used in personal care, home care, workplace and fabric care products often fail to deliver consistent performance, as the active ingredients tend to degrade through oxidation and hydrolysis when exposed to water during manufacturing. These actives further degrade during the distribution stage. These actives still further degrade during the shelf-time at point of sale (POS), be it offline or online distribution centers.
[0010] Finally, when they reach the consumer, these actives further degrade in the consumer’s shelf over the period of use. The role of actives in personal, home, office, workplace and fabric care is paramount as it directly relates to the performance of products, thereby directly relating to the consumer satisfaction index. If the product performs better and quicker, the consumer satisfaction index shoots up. The traditional product lifecycle approach involves adding water at the manufacturing stage of the product which leads to inefficiencies multiplying at each stage of the product lifecycle ultimately adding significantly to carbon emissions and climate crisis.
[0011] Effervescent tablet technologies, which combine solid acids and bases to generate carbon dioxide and rapidly dissolve into a use-solution, have been used as a method for delivering cleaning products. These tablets offer advantages such as reducing the need to ship water, enabling convenient, on-demand preparation and the like. However, the existing effervescent products fail to deliver the desired levels of cleaning performance, multi-functionality, sensory experience and safety. Known effervescent formulations fail to protect sensitive or volatile active ingredients from interaction or degradation during storage. The viability of conventionally known probiotic effervescent tablets are preserved through reduced compaction force. However, these probiotic effervescent tablets cannot maintain high residual activity due to degradation caused by pre-hydrolysis.
[0012] Further, conventional acid-base effervescent blends tend to neutralize each other, yielding only mild to moderate pH, which is insufficient for removal of heavy scale.
[0013] Furthermore, conventional tablet formulations are mainly designed for foam pumps and fine- mist sprayers, and often rely on thickeners or conventional viscosity modifiers, which can clog spray nozzles and foaming mechanisms, making refilling across various consumer devices or dispensers difficult. To address this issue, some formulations adopted extremely low-viscosity solutions or completely eliminated them to prevent clogging. However, these thin solutions often drip from surfaces, resulting in poor deposition, limited coverage, and subpar sensory performance in personal care and homecare applications.
[0014] Therefore, there is felt a need to provide a tablet composition that can mitigate the drawbacks mentioned hereinabove or at least provides an alternative solution.
[0015] OBJECTS
[0016] Some of the objects of the present disclosure, which at least one embodiment herein satisfies, are as follows.
[0017] An object of the present disclosure is to ameliorate one or more problems of the background or to at least provide a useful alternative.
[0018] Another object of the present disclosure is to provide a controlled-release, tablet composition.
[0019] Still another object of the present disclosure is to provide a composition that is multifunctional, has enhanced stability and potency, and comprises with environmental impact tracking.
[0020] Yet another object of the present disclosure is to provide a kit comprising a controlled- release, tablet composition, a dispensing device and a set of instructions for use thereof.
[0021] Still another object of the present disclosure is to provide a process for the preparation of a controlled-release, tablet composition.
[0022] Other objects and advantages of the present disclosure will be more apparent from the following description, which is not intended to limit the scope of the present disclosure. SUMMARY
[0023] The present disclosure provides a controlled-release, tablet composition comprising (a) an effervescent agent comprising an acid component and a base component; (b) at least one water soluble active agent selected from the group consisting of a vitamin, a provitamin, a cofactor complex, an enzyme, a probiotic, a postbiotic, a microbial culture, a botanical extract, an algal extract, a marine extract, a fungal extract, a microbial extract, a peptide, a mineral extract, an antimicrobial agent, an anti-inflammatory agent, a bleaching agent, a whitening agent, a conditioning agent, an optical brightener, a cleaning agent, a disinfectant, an insect repellent, a colour-modifying agent, a cleansing agent, a therapeutic agent, a tan enhancer and a sun care agent; (c) a carrier molecule; (d) a rheology modifier; and (e) at least one water soluble excipient selected from the group consisting of a humectant, a moisturizing agent, an emulsifier, a pH modifier, a buffering agent, an antioxidant, a stabilizer, a sequestering agent, a solubilizer, a dispersant, a wetting agent, a surfactant, a viscosity modifier, a thickening agent, a foaming agent, an anti -foaming agent, a binder, a disintegrant, chelating agent, a lubricant, a flow aid, an anti-caking agent, a plasticizer, a film former, a bulking agent, a filler, a colorant, an opacifier, a fragrance, a preservative, a UV absorber and a corrosion inhibitor.
[0024] In an embodiment of the present disclosure, the composition comprises at least one water soluble active agent or water miscible active agent or water dispersible active agent; and at least one water soluble excipient or water miscible excipient or water dispersible excipient.
[0025] The composition of the present disclosure is contained in a package comprising an integrated blockchain-linked or an QR code technology ("Proof-of-Green"), configured to enable realtime tracking and transparent display of environmental sustainability metrics selected from the group consisting of reduction in plastic waste, water usage, fuel consumption, and overall carbon footprint.
[0026] In another aspect, there is provided a kit comprising the controlled release, tablet composition of the present disclosure, a dispenser device and a set of instructions for use thereof.
[0027] In another aspect of the present disclosure, there is provided a process for preparing a controlled release, tablet composition comprising the following steps: i. blending predetermined amounts of ingredients at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a master blend; ii. optionally, granulating the master blend by using a binder at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 %, followed by drying and milling to obtain a milled blend; iii. optionally, lubricating the master blend or said milled blend by using a lubricant at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a lubricated mixture; and iv. compressing the master blend or the milled blend or the lubricated mixture by exerting a force in the range of 5 tons to 25 tons at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain the controlled release, tablet composition, in the form of a tablet.
[0028] DETAILED DESCRIPTION
[0029] The present disclosure relates to personal, home, office, workplace and fabric care products. Particularly, the present disclosure relates to multi-functional controlled-release tablet compositions for consumer products.
[0030] Embodiments, of the present disclosure, will now be described herein. Embodiments are provided so as to thoroughly and fully convey the scope of the present disclosure to the person skilled in the art. Numerous details are set forth, relating to specific components, and methods, to provide a complete understanding of embodiments of the present disclosure. It will be apparent to the person skilled in the art that the details provided in the embodiments should not be construed to limit the scope of the present disclosure. In some embodiments, well-known processes, well-known apparatus structures, and well-known techniques are not described in detail.
[0031] The terminology used, in the present disclosure, is only for the purpose of explaining a particular embodiment and such terminology shall not be considered to limit the scope of the present disclosure. As used in the present disclosure, the forms "a,” "an," and "the" may be intended to include the plural forms as well, unless the context clearly suggests otherwise. The terms "comprises," "comprising," “including,” and “having,” are open ended transitional phrases and therefore specify the presence of stated features, integers, steps, operations, elements, modules, units and / or components, but do not forbid the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or groups thereof. The particular order of steps disclosed in the method and process of the present disclosure is not to be construed as necessarily requiring their performance as described or illustrated. It is also to be understood that additional or alternative steps may be employed.
[0032] As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed elements.
[0033] The terms first, second, third, etc., should not be construed to limit the scope of the present disclosure as the aforementioned terms may be only used to distinguish one element, component, region, layer or section from another component, region, layer or section. Terms such as first, second, third etc., when used herein do not imply a specific sequence or order unless clearly suggested by the present disclosure.
[0034] The active ingredients of conventional liquid products for personal, home, office, workplace, and fabric care degrade due to oxidation and hydrolysis when water is introduced during manufacturing. This degradation continues throughout the distribution cycle, storage, and consumer use, reducing product effectiveness and consumer satisfaction. Adding water early in the product lifecycle also leads to inefficiencies that increase carbon emissions and environmental impact.
[0035] Effervescent tablet technology, which uses solid acids and bases to generate carbon dioxide and dissolve into a use-solution on demand, offers benefits such as reduced water shipping and convenient preparation. However, conventional effervescent products often lack adequate cleaning performance, multi-functionality, and safety. They also fail to protect sensitive or volatile actives during storage. The viability of conventionally known probiotic effervescent tablets are preserved through reduced compaction force. However, these probiotic effervescent tablets cannot maintain high residual activity due to degradation caused by prehydrolysis.
[0036] Further, conventional effervescent tablets designed for use with foam pumps and fine-mist sprayers contain thickeners that clog nozzles thereby making the refilling process more difficult. Though, low-viscosity solutions prevent clogging, however, they tend to drip, resulting in poor coverage and sensory experience in personal care products.
[0037] The present disclosure addresses these issues by providing tablet compositions that are easy to use, precisely dosed, and environmentally friendly, besides significantly boosting the performance of products by enhancing the performance of active agent(s) in skin-care, cleansers and other applications by a substantial amount, helping users achieve faster results in various applications, thereby elevating consumer satisfaction and brand perception.
[0038] In an aspect of the present disclosure, there is provided a controlled-release, tablet composition comprising: (a) an effervescent agent comprising an acid component and a base component; (b) at least one water soluble active agent selected from the group consisting of a vitamin, a provitamin, a cofactor complex, an enzyme, a probiotic, a postbiotic, a microbial culture, a botanical extract, an algal extract, a marine extract, a fungal extract, a microbial extract, a peptide, a mineral extract, an antimicrobial agent, an anti-inflammatory agent, a bleaching agent, a whitening agent, a conditioning agent, an optical brightener, a cleaning agent, a disinfectant, an insect repellent, a colour-modifying agent, a cleansing agent, a therapeutic agent, a tan enhancer and a sun care agent; (c) a carrier molecule; (d) a rheology modifier; and (e) at least one water soluble excipient selected from the group consisting of a humectant, a moisturizing agent, an emulsifier, a pH modifier, a buffering agent, an antioxidant, a stabilizer, a sequestering agent, a solubilizer, a dispersant, a wetting agent, a surfactant, a viscosity modifier, a thickening agent, a foaming agent, an anti-foaming agent, a binder, a disintegrant, chelating agent, a lubricant, a flow aid, an anti-caking agent, a plasticizer, a film former, a bulking agent, a filler, a colorant, an opacifier, a fragrance, a preservative, a UV absorber and a corrosion inhibitor
[0039] In an embodiment of the present disclosure, the composition comprises
[0040] - at least one water soluble active agent or water miscible active agent or water dispersible active agent; and
[0041] - at least one water soluble excipient or water miscible excipient or water dispersible excipient. In an embodiment of the present disclosure, (a) the effervescent agent is present in an amount in the range of 5 mass% to 75 mass%; (b) the active agent is present in an amount in the range of 0.1 mass% to 80 mass%; (c) the carrier molecule is present in an amount in the range of 0 mass% to 50 mass%; (d) the rheology modifier is present in an amount in the range of 0 mass% to 25 mass%; and (e) the excipient is present in an amount in the range of 0.1 mass% to 70 mass%; wherein the mass% of each ingredient is with respect to the total mass of the composition.
[0042] In an exemplary embodiment of the present disclosure, (a) the effervescent agent is present in an amount in the range of 15 mass% to 50 mass%; (b) the active agent is present in an amount in the range of 2 mass% to 55 mass%; (c) the carrier molecule is present in an amount in the range of 1 mass% to 40 mass%; and (d) the rheology modifier is present in an amount in the range of 0. 1 mass% to 5 mass%; and (e) the excipient is present in an amount in the range of 15 mass% to 70 mass%; wherein the mass% of each ingredient is with respect to the total mass of the composition.
[0043] In an embodiment of the present disclosure, the composition comprises (a) an effervescent agent comprising an acid component and a base component; (b) at least one active agent selected from the group consisting of a disinfectant, a vitamin, an insect repellent, an antiinflammatory agent, a peptide, an enzyme, an antimicrobial agent and a probiotic, wherein the active agent is water soluble or water miscible or water dispersible; (c) a carrier molecule; (d) a rheology modifier; and (e) at least one excipient selected from the group consisting of a surfactant, a preservative, a solubilizer, a chelating agent, a filler, a humectant, a fragrance and a foaming agent, wherein the excipient is water soluble or water miscible or water dispersible.
[0044] In an embodiment of the present disclosure, the acid component is selected from the group consisting of betaine hydrochloride, citric acid, tartaric acid, malic acid, fumaric acid, lactic acid, adipic acid, maleic acid, glycolic acid, gluconic acid, acetic acid, formic acid, benzoic acid, sorbic acid, oxalic acid, salicylic acid, mandelic acid, phosphoric acid, sulphamic acid, hydrochloric acid, nitric acid, boric acid, carbonic acid and a combination thereof; and the base component is selected from the group consisting of sodium carbonate, sodium bicarbonate, calcium carbonate, potassium bicarbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, sodium metasilicate, sodium hydroxide, a percarbonate, a perborate, a borate, an amino-alcohol base and a combination thereof.
[0045] In an embodiment of the present disclosure, a molar ratio of the acid component to the base component in the effervescent agent is in the range of 1 : 10 to 10: 1.
[0046] In an exemplary embodiment of the present disclosure, the acid component is betaine hydrochloride (betaine HC1). In another exemplary embodiment of the present disclosure, the acid component is citric acid. In still another exemplary embodiment of the present disclosure, the acid component is a combination of citric acid and betaine HC1.
[0047] In an exemplary embodiment of the present disclosure, the base component is sodium carbonate. In another exemplary embodiment of the present disclosure, the base component is sodium bicarbonate. In still another exemplary embodiment of the present disclosure, the base component is a combination of sodium carbonate and sodium bicarbonate.
[0048] In an embodiment of the present disclosure, a mass ratio of sodium carbonate to sodium bicarbonate is in the range of 1 : 10 to 10: 1.
[0049] In an exemplary embodiment of the present disclosure, the mass ratio of sodium carbonate to sodium bicarbonate is in the range of 1 : 1 to 3 : 1.
[0050] In an embodiment of the present disclosure, the effervescent agent is capable of providing a controlled effervescent system, facilitating broad pH adjustability and enhanced functional performance.
[0051] The conventional effervescent products are typically limited to narrow pH ranges. However, the use of the specific acid-base combinations in the composition of the present disclosure enables production of highly acidic solutions having pH <1.5 or strongly alkaline solutions having pH> 9. The incorporation of betaine hydrochloride enables very low pH (< 1.5) outperforming conventional effervescent citric-acid-based systems in descaling, disinfecting, and cleaning efficacy. The low pH that is useful in applications such as toilet cleaning, hard scale removal and the like, which is not possible using conventional compositions.
[0052] The effervescent reaction of the present disclosure is controlled by optimizing the acid-to- base molar ratio allowing for controlled, spill-free, and low-foaming dissolution, while ensuring rapid and efficient dispersion of the active agents.
[0053] The composition of the present disclosure is capable of delivering a wide variety of active agents based on its biological and chemical action. The active agents used in the composition of the present disclosure are capable of: providing antioxidant properties, skin nourishment and hydration; enhancing skin appearance by promoting renewal and collagen synthesis; strengthening and repairing hair fibers; cleaning activity; microbial control; sun care activity; and therapeutic activity such as anti-inflammatory activity, analgesics and cooling activity.
[0054] The composition of the present disclosure is capable of incorporating and delivering a broad spectrum of active agents suitable for applications in personal care, home care, workplace or office environments, and fabric care.
[0055] In one embodiment of the present disclosure, the composition comprises a single active agent. In another embodiment of the present disclosure, the composition comprises a combination of two or more active agents.
[0056] In an embodiment of the present disclosure, the composition comprises at least one active agent selected from the group consisting of a vitamin, a provitamin, a cofactor complex, an enzyme, a probiotic, a postbiotic, a microbial culture, a botanical extract, an algal extract, a marine extract, a fungal extract, a microbial extract, a peptide, a mineral extract, an antimicrobial agent, an anti-inflammatory agent, a bleaching agent, a whitening agent, a conditioning agent, an optical brightener, a cleaning agent, a disinfectant, an insect repellent, a colour-modifying agent, a cleansing agent, a therapeutic agent, a tan enhancer and a sun care agent.
[0057] In an exemplary embodiment of the present disclosure, the composition comprises at least one active agent selected from the group consisting of a disinfectant, a vitamin, an insect repellent, an anti-inflammatory agent, a peptide, an enzyme, an antimicrobial agent and a probiotic.
[0058] In an embodiment of the present disclosure, the active agent is water soluble.
[0059] In another embodiment of the present disclosure, the active agent is water miscible.
[0060] In still another embodiment of the present disclosure, the active agent is water dispersible.
[0061] In an embodiment of the present disclosure, the disinfectant is selected from the group consisting of n-alkyl dimethyl benzyl ammonium chloride, n-alkyl dimethyl ethylbenzyl ammonium chloride, chloroxylenol, o-phenylphenol, cetylpyridinium chloride (CPC), benzethonium chloride, chlorhexidine gluconate, sodium hypochlorite, hydrogen peroxide, ethanol, isopropyl alcohol, povidone-iodine, thymol, silver nanoparticles, pine oil disinfectant, hypochlorous acid, glutaraldehyde and a combination thereof.
[0062] In an exemplary embodiment of the present disclosure, the n-alkyl dimethyl benzyl ammonium chloride is selected from the group consisting of didecyldimethyl-ammonium chloride (DDAC), octyl-decyl-dimethyl-ammonium chloride (ODAC), dioctyl-dimethyl-ammonium chloride (DODAC), stearyl-dimethyl-benzyl-ammonium chloride (SDBAC), alkyl (Ci2-Cie) dimethyl benzyl ammonium bromide (ADBAB), didecyldimethyl-ammonium bromide (DDAB), and a combination thereof.
[0063] In an embodiment of the present disclosure, the vitamin is selected from the group consisting of vitamin A, vitamin Bl, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin
[0064] B7, vitamin B9, vitamin Bl 2, vitamin C, vitamin D, vitamin D2, vitamin D3, vitamin E, vitamin K, vitamin K2, vitamin K3, retinol, retinyl palmitate, thiamine HC1, riboflavin-5- phosphate, niacinamide, calcium pantothenate, pyridoxine-HCl, biotin, folic acid, methylcobalamin, sodium ascorbyl phosphate, ergocalciferol, cholecalciferol, tocopheryl acetate, phylloquinone, menaquinone-7 and a combination thereof.
[0065] In an embodiment of the present disclosure, the insect repellent is selected from the group consisting of 3-(N-butyl acetamido)-propionic acid ethyl ester (IR3535), pyrethrin, permethrin, piperonyl butoxide, N,N-diethyl-meta-toluamide (DEET), icaridin (picaridin), citronella oil, p- menthane-3,8-diol, geraniol, soybean oil, catnip oil and a combination thereof.
[0066] In an embodiment of the present disclosure, the anti-inflammatory agent is selected from the group consisting of sodium salicylate, methyl salicylate, beta hydroxy acid, allantoin, hydrocortisone and a combination thereof.
[0067] In an embodiment of the present disclosure, the peptide is selected from the group consisting of acetyl hexa peptide-8-amide, a phyto peptide, an acetyl peptide, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, a copper peptide, dipeptide-2, palmitoyl tripeptide-5, palmitoyl oligopeptide, acetyl dipeptide- 1 cetyl ester, a collagen peptide, an elastin peptide, a silk peptide, a wheat peptide, a soy peptide, a rice peptide, a keratin peptide, a phytocannabinoid peptide, a seaweed peptide, a phytocomplex peptide, an antimicrobial peptide, tripeptide- 1, hexapeptide- 9, pentapeptide- 18 and a combination thereof.
[0068] In an embodiment of the present disclosure, the enzyme is selected from the group consisting of protease, amylase, lipase, cellulase, mannanase, pectinase, keratinase, lactoperoxidase, superoxide dismutase, laccase, urease, phytase, papain, bromelain and a combination thereof. In an embodiment of the present disclosure a mixture of enzymes is used in the composition to provide the desired functionality. In an exemplary embodiment of the present disclosure, the enzyme is a mixture of protease and amylase.
[0069] Enzymes are incorporated into the composition alongside a carrier molecule for controlled release, producing a solution upon dissolution in water that is effective against tough stains such as gravy, milk, tea and the like enabling efficient cleaning and odor control without high doses of harsh surfactants.
[0070] In an embodiment of the present disclosure the antimicrobial agent is selected from the group consisting of tea tree oil, thyme oil, eucalyptus oil, polylysine and a combination thereof.
[0071] In an embodiment of the present disclosure, the probiotic is a bacteria or a yeast and is selected from the group consisting of Bacillus, Lactobacillus, Bifidobacterium, Pediococcus, Streptococcus thermophilus, Enterococcus faecium, Propionibacterium, Clostridium butyricum, Kluyveromyces, Debaryomyces, Saccharomyces and mixtures thereof.
[0072] The probiotics are incorporated into the composition alongside a carrier molecule for controlled release, producing a solution upon dissolution in water that effectively provides restoration of the skin microbiome with other benefits such as de-odourising, without the use of harsh chemicals.
[0073] In an embodiment of the present disclosure the provitamin is selected from the group consisting of P-carotene, a-carotene, lutein, zeaxanthin, -cryptoxanthin, lycopene, panthenol (provitamin B5), menadione (provitamin K), eigosterol (provitamin D2), 7- dehydrocholesterol (provitamin D3), S-methyl-L-methionine and a combination thereof.
[0074] In an embodiment of the present disclosure, the active agent is selected from the group consisting of natural oil (argon oil) and a plant butter, (shea butter, cocoa butter).
[0075] In an embodiment of the present disclosure, the active agent is a therapeutic active agent and is selected from the group consisting of an analgesic, an antipyretic, an electrolyte, a rehydration agent, an antihistamine, a decongestant, a gastrointestinal agent, a cough and cold remedy, an antiparasitic and a combination thereof.
[0076] In an embodiment of the present disclosure, the therapeutic active agent is a natural compound. In another embodiment of the present disclosure, the therapeutic active agent is a synthetic compound. In an embodiment of the present disclosure, the active agent is a bleaching or a whitening active and is selected from the group consisting of hydrogen peroxide, sodium percarbonate, hydroquinone, kojic acid, azelaic acid, liquorice extract and a combination thereof.
[0077] In an embodiment of the present disclosure, the active agent is a botanical extract and is obtained from a plant selected from the group consisting of green tea, almond, saffron, turmeric, curcumin, chamomile, basil, mint, ginger, peppermint, ginseng, garlic calendula, rosemary, sea buckthorn, witch hazel, hibiscus, rosehip, moringa, jojoba, argan, lavender, cucumber, elderflower, gotu kola (Centella asiatica), pomegranate, blueberry, raspberry, matcha, watermelon, kiwi, papaya, avocado and a combination thereof.
[0078] In an embodiment of the present disclosure, the active agent is an algal extract and is obtained from an alga selected from the group consisting of green algae, red algae, brown algae, blue-green algae, microalgae and a combination thereof.
[0079] In an embodiment of the present disclosure, the active agent is a microbial extract and is in a form selected from the group consisting of an enzyme, a peptide, spores, live culture, inactivated culture, lysate and a combination thereof.
[0080] In an embodiment of the present disclosure, the active agent is a sun care active and is selected from the group consisting of avobenzone, zinc oxide and their derivatives. In an embodiment of the present disclosure, the sun care active is microencapsulated.
[0081] In an embodiment of the present disclosure, the active agent is a tan enhancer and is selected from dihydroxyacetone (DHA) and their derivatives.
[0082] In an embodiment of the present disclosure, the composition comprises a carrier molecule.
[0083] The carrier molecules used in the composition of the present disclosure forms inclusion complexes with volatile and unstable active agents, fragrances and the like ensuring zero pump clogging. Further, the carrier molecules have a high water solubility ensuring a transparent and clear solution.
[0084] In an embodiment of the present disclosure, the carrier molecule is selected from the group consisting of maltodextrin, amylodextrin, a,P-dextrin, cyclodextrin, zeolite, talc, starch and their derivatives.
[0085] In an embodiment of the present disclosure, the carrier molecule is characterized by: a molecular weight in the range of 1.2 kDa to 1.5 kDa; and a molar substitution in the range of 3.0 to 4.5. In an exemplary embodiment of the present disclosure, the carrier molecule is hydroxypropyl-P-cyclodextrin (HPpCD) having a molecular weight in the range of 1.2 kDa to 1.5 kDa and a molar substitution in the range of 3 to 4.5 (7*MS).
[0086] Molar substitution (MS) indicates the average number of hydroxypropyl groups attached to each glucose unit in HPpCD, which has 7 glucose units arranged in a ring. An MS of 3 to 4.5 means that, on average, each of the 7 glucose units in the P-cyclodextrin ring has 3 to 4.5 hydroxypropyl groups attached resulting in a total of 21 to 31.5 hydroxypropyl groups per HPpCD molecule (7 units x 3.0-4.5 MS). The hydroxypropyl-P-cyclodextrin used in the composition of the present disclosure has a high degree of substitution of about 21 to 32 hydroxypropyl groups per molecule resulting in significantly enhanced aqueous solubility compared to the native PCD. Thus, the hydroxypropyl-P-cyclodextrin used in the present disclosure enables enhanced complex forming property facilitating efficient encapsulation and stabilization of different active agents, thereby improving their bioavailability and formulation performance.
[0087] Further, the HPpCD having the specific molecular weight and molar substitution as mentioned above is capable of functioning across different foam pumps and fine-mist finger sprayers without clogging or blocking the pump for a minimum of 500 actuations.
[0088] In an embodiment of the present disclosure, the HPpCD is capable of functioning as a carrier for sensitive ingredients such as vitamins, fragrances, essential oils, probiotics, enzymes, antimicrobials, peptides and the like.
[0089] In an embodiment of the present disclosure, biological active agents are stabilized through pre-tableting complexation / encapsulation with HPpCD. The encapsulation reduces water activity (aw < 0.20), protects hydrophobic regions, and preserves steric spacing, thereby enhancing the stability, potency, and shelf-life of biological active agents such as enzymes, probiotics and the like, ensuring improved functional performance upon use.
[0090] The HPpCD are ring-shaped molecules made from sugar units having a hydrophobic (waterrepelling) interior and a hydrophilic (water-attracting) exterior allowing it to trap the sensitive ingredients inside the ring to form an inclusion complex. The formation of the inclusion complex stabilizes the ingredients by shielding them from oxygen, light, and moisture, thereby preventing degradation of the active agents / ingredients before the product is used and helps to maintain the full potency of the actives till the actual use. The formation of the inclusion complex thus helps in overcoming the stability limitation present in conventional aqueous products. Further, fragrance oils encapsulated within the HPpCD form clear, stable aqueous solutions upon dissolution of the composition, preventing oily droplets that commonly clog foaming pumps and fine-mist sprayers, ensuring clog-free dispensing throughout the product usage.
[0091] In an embodiment of the present disclosure, the hydroxypropyl-P-cyclodextrin (HPpCD) is capable of co-encapsulating fragrance oils together with non-volatile ethoxylated alcohols, such as C16-C18 EO25 and functional equivalents, to form a dual-guest inclusion complex. This complex facilitates differential release kinetics, enabling a unique ternary system that provides a rapid initial release of top-note fragrance components, followed by a sustained release of base notes, thereby enhancing long-lasting sensory perception. The non-volatile ethoxylated alcohol weakens the volatility of the top notes of fragrance (K_app J, ~40 %), giving a fast initial burst. Less-volatile base notes remain strongly bound (K_app ~ 105M '). supplying a slow “tail”. Outside the cavity, the EO-chain lowers interfacial tension to 2.5 mN m1at 0.05 % w / v, keeping 5-6 wt % perfume dissolved as a single, clear phase. As the nonvolatile ethoxylated alcohol is largely hidden in the complex, it does not foam and the resulting solution remains clear, single-phase, and exhibits minimal foam generation, making it particularly suitable for fine-mist and non-foaming applications. In an embodiment of the present disclosure, the non-volatile ethoxylated alcohol has a hydrophile-lipophile balance (HLB) in the range of 14 to 16.
[0092] The carrier molecule in the composition of the present disclosure forms complexes with the ingredients by encapsulating the ingredients and thus enhances the ingredient distribution, increases liquid-holding capacity, optimized, delayed release upon contact with water and improves overall efficiency of the composition when dissolved in water. The carrier molecule surrounds / incorporates the ingredients within its structure leading to enhanced stability, solubility, and controlled release of the ingredients when the composition is dissolved in water.
[0093] In an embodiment of the present disclosure, the composition comprises a rheology modifier.
[0094] In an embodiment of the present disclosure, the rheology modifier is a polymer characterized by: a molecular weight in the range of 1.5 x 106Daltons to 2.5 x 106Daltons; a transmittance in the range of 80 % to 98 % at 600 nm; a viscosity in the range of 800 mPa.s to 1300 mPa s at 60 rpm; and a viscosity ratio in the range of 1.02 to 1.60 at 3 rpm / 60 rpm.
[0095] In an embodiment of the present disclosure, the rheology modifier is selected from the group consisting of xanthan gum, carrageenan, guar gum, sclerotium gum and an alginate.
[0096] In an embodiment of the present disclosure, the rheology modifier is a clarified low-viscosity polymer capable of providing dispensing compatibility. The rheology modifier used in the composition of the present disclosure has very low-elasticity which provides optimal viscosity, low shear-thinning elasticity and clinging properties without compromising transparency while also ensuring zero blockages in foam and fine mist sprayers.
[0097] In an exemplary embodiment of the present disclosure, the rheology modifier is xanthan gum.
[0098] In an embodiment of the present disclosure, the rheology modifier ensures uninterrupted operation across dispensing formats, such as mesh-type foam pumps, trigger sprayers and the like, enabling uniform product delivery, superior clinging properties, along with enhanced consumer experience across personal care, household, and fabric cleaning applications.
[0099] Both the carrier molecule and the low-viscosity rheology modifier used in the compositions of the present disclosure; individually or in combination, contribute to preventing clogging or blockages in dispensers, while ensuring optimal flow, enhanced foam quality, improved sensory experience, and consistent performance in foam-based applications such as body wash, face wash, hand wash, shaving foams, dishwashing foam sprays, toilet cleaner foam sprays, and the like.
[0100] The composition of the present disclosure uses a wide variety of excipients, based on the intended end user, the specific application, and the desired functional or aesthetic properties of the final product.
[0101] In an embodiment of the present disclosure, the excipient is selected from the group consisting of a humectant, a moisturizing agent, an emulsifier, a pH modifier, a buffering agent, an antioxidant, a stabilizer, a sequestering agent, a solubilizer, a dispersant, a wetting agent, a surfactant, a viscosity modifier, a thickening agent, a foaming agent, an anti-foaming agent, a binder, a disintegrant, chelating agent, a lubricant, a flow aid, an anti-caking agent, a plasticizer, a film former, a bulking agent, a filler, a colorant, an opacifier, a fragrance, a preservative, a UV absorber and a corrosion inhibitor.
[0102] In an embodiment of the present disclosure, the excipient is water soluble. In another embodiment of the present disclosure, the excipient is water miscible. In still another embodiment of the present disclosure, the excipient is water dispersible.
[0103] In an exemplary embodiment of the present disclosure, the excipient is selected from the group consisting of a surfactant, a preservative, a solubilizer, a chelating agent, a filler, a humectant, a fragrance and a foaming agent.
[0104] In an embodiment of the present disclosure, the surfactant is selected from the group consisting of an anionic surfactant, a cationic surfactant, a non-ionic surfactant, an amphoteric surfactant and a combination thereof.
[0105] In an embodiment of the present disclosure, the anionic surfactant is selected from the group consisting of a sulfate, a sulfonate, a carboxylate, a phosphate, an isethionate, a glutamate, a sulfoacetate, an a-olefm sulfonate, an amino-acid-derived anionic surfactant and their derivatives; the cationic surfactant is selected from the group consisting of a quaternary ammonium surfactant, an esterquat, a poly(amino-acid) cationic surfactant and their derivatives; the non-ionic surfactant is selected from the group consisting of an alkyl polyglucoside, a fatty-alcohol ethoxylate, a polysorbate, a methyl-ester ethoxylate and their derivatives; and the amphoteric surfactant is selected from the group consisting of a sultaine, a sarcosinate, an imidazoline, an amine-oxide surfactant and their derivatives.
[0106] In an embodiment of the present disclosure, the preservative is selected from the group consisting of sodium benzoate, potassium sorbate, polylysin, carvacrol, phenoxyethanol, ethylhexyl glycerin, caprylyl glycol, sodium levulinate, sodium anisate, grapefruit seed extract, rosemary extract, neem oil and a combination thereof.
[0107] In an embodiment of the present disclosure, the solubilizer is selected from the group consisting of polyethylene glycol, a polysorbate, capryl glucoside, caprylyl glucoside, lauryl glucoside, blend of polypropylene glycol (PPG)-26-Buteth-26; polyethylene glycol (PEG)-40 hydrogenated castor oil; water, blend of caprylyl / capryl glucoside; water; diisopropyl adipate; triethyl citrate, blend of decyl glucoside; water; diisopropyl adipate; triethyl citrate; citric acid and a combination thereof.
[0108] In an embodiment of the present disclosure, the chelating agent is selected from the group consisting of trisodium salt of methylglycinediacetic acid, ethylenediaminetetraacetic acid (EDTA), microencapsulated EDTA and its derivatives, glutamic acid diacetate, diethylenetriaminepentaacetic acid, l-hydroxyethylidene-l,l-diphosphonic acid, aminotrimethylenephosphonic acid, sodium gluconate, calcium gluconate, glutamic acid N,N- diacetic acid, polyaminocarboxylic acids, nitrilotriacetic acid, iminodisuccinic acid and ethylenediamine disuccinic acid, polyaspartic acid and a combination thereof. In an embodiment of the present disclosure, the fdler is selected from the group consisting of precipitated silica, modified silica, sodium chloride and a combination thereof.
[0109] In an embodiment of the present disclosure, the humectant and the moisturizing agent are independently selected from the group consisting of Aloe vera powder, glycerin, a seaweed extract, sorbitol, xylitol, ectoin, trehalose, glycotoin, a polyquatemium, a hyaluronic acid polymer derivative, urea, a ceramide and a combination thereof.
[0110] In an embodiment of the present disclosure, the foaming agent is selected from the group consisting of sodium stearate, sodium palmitate, sodium lauryl sulfate, sodium laureth sulfate, sodium lauroyl sarcosinate, sodium cocoyl glutamate, sodium alpha olefin sulfonate, sodium cocoyl isethionate, disodium cocoyl glutamate, cocamidopropyl betaine, soapnut extract, yucca extract, quillaja extract, polymeric foaming agent, blend of polyethylene glycol (PEG) and PEG-12 dimethicone and a combination thereof.
[0111] In an embodiment of the present disclosure, the fragrance is selected from the group consisting of floral fragrance, citrus fragrance, aquatic fragrance, herbal fragrance, woody fragrance, fruity fragrance, spicy fragrance, gourmand fragrance, green fragrance, oriental fragrance and a combination thereof.
[0112] In an embodiment of the present disclosure, the floral fragrance is selected from the group consisting of rose, jasmine, lavender, lily, gardenia and a combination thereof; the citrus fragrance is selected from the group consisting of lemon, lime, orange, beigamot, grapefruit and a combination thereof; aquatic fragrance is selected from the group consisting of marine, sea-breeze, ozone and a combination thereof; herbal fragrance is selected from the group consisting of mint, eucalyptus, sage, rosemary and a combination thereof; the woody fragrance is selected from the group consisting of sandalwood, cedarwood, vetiver, patchouli, agarwood (oud) and a combination thereof; the fruity fragrance is selected from the group consisting of apple, pear, peach, mango, berries, melon and a combination thereof; the spicy fragrance is selected from the group consisting of cinnamon, nutmeg, cardamom, clove, black pepper and a combination thereof; the gourmand fragrance is selected from the group consisting of vanilla, caramel, chocolate, honey and a combination thereof; the green fragrance is selected from the group consisting of fresh-cut grass, bamboo, tea leaves and a combination thereof; and the oriental fragrance is selected from the group consisting of amber, musk, incense and a combination thereof.
[0113] In an embodiment of the present disclosure, the fragrance is in the form of concentrated fragrance. The use of concentrated fragrance ensures stronger and longer-lasting aroma, controlled release upon activation, customizable sensory profile and is cost-effective. Further, the concentrated fragrance in dry / solid effervescent tablet composition of the present disclosure, reduces risk of oxidation or evaporation before use and hence is more stable during storage compared to those in liquid products. The carrier molecule in the composition enhances fragrance stability and performance, while enabling customizable strength and blending of multiple fragrances for personalized perfumes, mists, or odor control solutions, enhancing consumer satisfaction.
[0114] The compositions of the present disclosure include different fragrances and be packaged in multi-tablet packs with shapes that minimize contact between units, reducing fragrance mixing and enabling greater variety without excessive packaging, leading to enhanced consumer experience.
[0115] In an embodiment of the present disclosure, the composition comprises a binder and is selected from the group consisting of croscarmellose sodium, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone and hydroxypropyl cellulose.
[0116] In an embodiment of the present disclosure, the composition comprises an emulsifier. In an embodiment of the present disclosure, the emulsifier is a natural emulsifier. In another embodiment of the present disclosure, the emulsifier is a synthetic emulsifier.
[0117] In an embodiment of the present disclosure, the emulsifier is selected from the group consisting of:
[0118] - non-ionic emulsifiers: fatty alcohol ethoxylates (ceteareth-20, steareth-10), sorbitan esters, polysorbates (sorbitan oleate and polysorbates) and their derivatives;
[0119] - anionic emulsifiers: soap-based emulsifiers (potassium stearate and sodium stearoyl lactylate);
[0120] - cationic emulsifiers: quaternary ammonium compounds (behentrimonium chloride, cetyl trimethyl ammonium chloride);
[0121] - amphoteric (zwitterionic) emulsifiers: betaines (cocamidopropyl betaine, coco- amidoethyl betaine);
[0122] - natural and bio-based emulsifiers: lecithins (soy lecithin, sunflower lecithin), pyrrolidone carboxylic acid (PCA), zinc pyrrolidone carboxylic acid and a mixture of olive oil and PCA;
[0123] - bio-derived polymers: xanthan gum, guar gum, acacia gum, algal extract, arginates, sclerotium gum and their derivates;
[0124] - hybrid emulsifiers: sorbitan esters + polysorbates, ceteareth + fatty alcohols, nonionic + cationic, lecithin + PEG-40 hydrogenated castor oil, glyceryl stearate + PEG- 100 stearate; and specialty emulsifiers: polyethylene glycol (PEG)-free emulsifiers.
[0125] The present disclosure provides combination delivery systems, tableting techniques, and tablet compositions designed for use across various applications such as personal care products (such as serums, shampoos, conditioners and body washes), home care products (such as surface cleaners and dishwashing detergents), and fabric care products (such as laundry detergents and fabric softeners). The compositions of the present disclosure are particularly suited for products where water constitutes a primary ingredient. In an embodiment of the present disclosure, the composition is dissolved in water in a predetermined mass ratio to obtain a product having a pH in the range of 0.5 to 14, for use as a consumer care product.
[0126] In an embodiment of the present disclosure, the predetermined mass ratio of the composition to water is in the range of 1: 1.5 to 1: 1000.
[0127] In an exemplary embodiment of the present disclosure, the predetermined mass ratio of the composition to water is in the range of 1 : 1.5 to 1 : 100.
[0128] In another exemplary embodiment of the present disclosure, the predetermined mass ratio of the composition to water is in the range of 1 : 1.5 to 1: 10.
[0129] In an embodiment of the present disclosure, the composition has a moisture level in the range of 0.1 mass% to 5 mass%. In an exemplary embodiment of the present disclosure, the composition has a moisture level <0.2 mass%.
[0130] In an embodiment of the present disclosure, the consumer care product is selected from the group consisting of a bodywash, a handwash, a facewash, a shampoo, a pet shampoo, a conditioner, a shaving foam, a serum, a toner, a mist, a perfume, an antibacterial cleaner, a sanitizer, a fabric cleaner, a fabric deodorizer, a fabric color protectant, a fabric softener, a wrinkle protectant, a fabric-detergent, a toilet cleaner, a bathroom cleaner, a floor cleaner, a multi-surface cleaner, an all-purpose cleaner, an air freshener, a degreaser, a carpet cleaner, a carpet shampoo, a disinfectant, an insect repellent, a grill cleaner, a furniture cleaner, a hard surface cleaner, a scale remover, a household cleaner, a glass cleaner, a deodorizer, a vegetable wash, a fruit wash, a virucidal agent, a stain remover, an oven cleaner, a dish wash, and a deteigent.
[0131] In an embodiment of the present disclosure, the composition is contained in a package comprising an integrated blockchain-linked or an QR code technology ("Proof-of-Green"), configured to enable real-time tracking and transparent display of environmental sustainability metrics selected from the group consisting of reduction in plastic waste, water usage, fuel consumption, and overall carbon footprint.
[0132] Each package that contains the composition of the present disclosure is printed with a unique QR code printed via a high speed inline printer that enables each package to be tracked individually across the entire supply chain cycle upto the recollection and processing for reusing using a specialized dashboard which also doubles down as a data analytics platform for both circularity and supply-chain tracking.
[0133] In an embodiment of the present disclosure, the composition comprises tracking of complete supply chain and algorithms for counterfeit elimination.
[0134] In an embodiment, the composition of the present disclosure, is packed in a packaging material selected from the group consisting of paper sachets with moisture barrier, aluminium tubes, plastic tubes, aluminium-aluminium (Alu / Alu) blister packs, strip packs and glass bottles. In an embodiment of the present disclosure, a desiccant is integrated into the packaging to protect the composition from moisture and maintain its stability throughout the shelf life.
[0135] In an aspect, there is provided a kit comprising the controlled release, tablet composition of the present disclosure, a dispensing device and a set of instructions for use thereof.
[0136] In an embodiment, the present disclosure provides a foam actuator specifically designed to enhance the foam profile in skin-care compositions such as body wash, facial cleansers, shaving foams, foaming hand cleansers and the like. The foam actuator features dual-channel dispersion nozzles with internal contours that precisely control the air-to-liquid ratio, ensuring optimal aeration and mixing of the liquid composition during dispensing. The design enhances foam stability, increases foam density and provides a luxurious sensory experience, thereby significantly elevating consumer satisfaction and composition performance across various personal care and dermatological products.
[0137] The composition of the present disclosure is designed to release its active agents over a specified period upon exposure to water in a controlled manner, ensuring consistent and prolonged functional effects. The included instructions guide the user about the appropriate handling, dissolution method, dosage, timing, and any safety or storage precautions necessary to maximize the efficacy and safety of the composition. The kit offers convenience, precision, and ease of use, especially for controlled delivery and user-friendly formats.
[0138] In another aspect of the present disclosure, there is provided a process for preparing a controlled release, tablet composition comprising the following steps: i. blending predetermined amounts of ingredients at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a master blend; ii. optionally, granulating the master blend by using a binder at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 %, followed by drying and milling to obtain a milled blend; iii. optionally, lubricating the master blend or the milled blend by using a lubricant at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a lubricated mixture; and iv. compressing the master blend or the milled blend or the lubricated mixture by exerting a force in the range of 5 tons to 25 tons at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain the controlled release, tablet composition, in the form of a tablet.
[0139] The process is described in detail.
[0140] Initially, a predetermined amounts of ingredients are blended at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a master blend.
[0141] In an embodiment of the present disclosure, the ingredients are selected from the group consisting of an effervescent agent having an acid component and a base component, an active agent, a carrier molecule, a rheology modifier, and at least one excipient, wherein the ingredients are in a form selected from powder, granule, paste, gel, liquid and emulsion.
[0142] In an embodiment of the present disclosure, the predetermined amount of the ingredients is as following: a. effervescent agent in an amount in the range of 5 mass% to 75 mass%; b. active agent in an amount in the range of 0.1 mass% to 80 mass%; c. carrier molecule in an amount in the range of 0 mass% to 50 mass%; d. rheology modifier in an amount in the range of 0 mass% to 25 mass%; and e. excipient in an amount in the range of 0. 1 mass% to 70 mass%; wherein the mass% of each ingredient is with respect to the total mass of the composition.
[0143] In an embodiment of the present disclosure, the active agent is selected from the group consisting of a vitamin, a provitamin, a cofactor complex, an enzyme, a probiotic, a postbiotic, a microbial culture, a botanical extract, an algal extract, a marine extract, a fungal extract, a microbial extract, a peptide, a mineral extract, an antimicrobial agent, an anti- inflammatory agent, a bleaching agent, a whitening agent, a conditioning agent, an optical brightener, a cleaning agent, a disinfectant, an insect repellent, a colour-modifying agent, a cleansing agent, a therapeutic agent, a tan enhancer and a sun care agent.
[0144] In an embodiment of the present disclosure, the active agent is water soluble. In another embodiment of the present disclosure, the active agent is water miscible. In still another embodiment of the present disclosure, the active agent is water dispersible.
[0145] In an exemplary embodiment of the present disclosure, the active agent is selected from the group consisting of a disinfectant, a vitamin, an insect repellent, an anti-inflammatory agent, a peptide, an enzyme, an antimicrobial agent and a probiotic.
[0146] In an embodiment of the present disclosure, the carrier molecule is selected from the group consisting of maltodextrin, amylodextrin, a,P-dextrin, cyclodextrin, zeolite, talc, starch and their derivatives. In an exemplary embodiment of the present disclosure, the carrier molecule is hydroxypropyl-P-cyclodextrin (HPBCD).
[0147] In an embodiment of the present disclosure, the rheology modifier is selected from the group consisting of xanthan gum, carrageenan, guar gum, sclerotium gum and an alginate. In an exemplary embodiment of the present disclosure, the xanthan gum.
[0148] In an embodiment of the present disclosure, the excipient is selected from the group consisting of a humectant, a moisturizing agent, an emulsifier, a pH modifier, a buffering agent, an antioxidant, a stabilizer, a sequestering agent, a solubilizer, a dispersant, a wetting agent, a surfactant, a viscosity modifier, a thickening agent, a foaming agent, an anti-foaming agent, a binder, a disintegrant, chelating agent, a lubricant, a flow aid, an anti-caking agent, a plasticizer, a film former, a bulking agent, a filler, a colorant, an opacifier, a fragrance, a preservative, a UV absorber and a corrosion inhibitor
[0149] In an embodiment of the present disclosure, the excipient is water soluble. In another embodiment of the present disclosure, the excipient is water miscible. In still another embodiment of the present disclosure, the excipient is water dispersible.
[0150] In an exemplary embodiment of the present disclosure, the excipient is selected from the group consisting of a surfactant, a preservative, a solubilizer, a chelating agent, a filler, a humectant, a fragrance and a foaming agent.
[0151] Blending is carried out using a technique selected from controlled sieving, and vortex mixing to achieve optimal ingredient distribution based on the specific application. The order of mixing the ingredients is optimized to ensure homogeneity, which is critical for compositions containing low- or high-dose active agents / ingredients in the form of liquids, emulsions, or nano-emulsions.
[0152] In an exemplary embodiment of the present disclosure, the blending is carried out at a temperature of 20 °C and a relative humidity (RH) of 20%.
[0153] Blending the ingredients at a controlled environment of 20 °C and a RH of 20% ensures uniform distribution of active agents and the other ingredients, which is critical for consistent controlled-release performance and dissolution behavior in tablets. It also aids in improving the tablet homogeneity, mechanical strength, and reproducibility during manufacturing.
[0154] The preparation of the composition of the present disclosure involves use of liquid ingredients, which may be volatile or non-volatile. When liquid ingredients are used for the preparation of the composition, a pre-treatment step is carried out to ensure their uniform distribution, prevent premature evaporation, and enhance stability during subsequent processing steps.
[0155] In an embodiment, the process of the present disclosure comprises a pre-treatment step prior to step (i), comprising blending the ingredients with a carrier molecule, followed by drying at a temperature in the range of -40 °C to 100 °C to obtain a pre-treated mixture.
[0156] In an embodiment of the present disclosure, volatile liquid ingredients are blended with the carrier molecule and then dried at a temperature in the range of -40 °C to 30 °C.
[0157] In another embodiment of the present disclosure, non-volatile liquid ingredients are blended with the carrier molecule and then dried at a temperature in the range of 30 °C to 100 °C.
[0158] In an embodiment of the present disclosure, the drying is carried out by a method selected from the group consisting of spray drying, vacuum drying and freeze drying.
[0159] The pre-treatment of the liquid ingredients enhances flowability, compressibility, and the controlled-release behavior, while also preventing moisture sensitivity and ingredient incompatibility ensuring consistent tablet quality, optimized dissolution, and scalable manufacturing. Blending the liquid and volatile components with the carrier molecules results in the formation of inclusion complexes which ensures controlled release, improved stability, and protection of the active agents / other ingredients from degradation or evaporation.
[0160] In an embodiment of the present disclosure, the pre-treated mixture is then blended with the remaining ingredients to obtain the master blend.
[0161] The so-obtained master blend is optionally granulated by using a binder at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25
[0162] %, followed by drying and milling to obtain a milled blend.
[0163] In an embodiment of the present disclosure, the granulation is wet granulation.
[0164] In an embodiment of the present disclosure, the binder is selected from the group consisting of croscarmellose sodium, sodium starch glycolate, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone, hydroxypropyl cellulose, xanthan gum, guar gum and polyethylene glycol.
[0165] In an embodiment of the present disclosure, the granulation is carried out using high-shear mixers, ultra-sonic mixers or fluid bed granulators.
[0166] The wet granulation of the blended ingredients enhances the granule formation and reduces subsequent processing time.
[0167] After the step of wet granulation, the ingredients are subjected to drying to a specified moisture content optimized to facilitate tableting and maintaining fragrance notes to obtain dried granules.
[0168] In an embodiment of the present disclosure, the drying is carried out by using a method selected from the group consisting of spray drying, and vacuum drying.
[0169] The dried granules are subjected to milling at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 %, followed by sieving to obtain a milled blend having a particle size in the range of 80 p to 300 p.
[0170] The particle size of the milled blend is a critical feature for ensuring the tablet uniformity and dissolution characteristics.
[0171] In the next step, the master blend or the milled blend is optionally lubricated by using a lubricant at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a lubricated mixture.
[0172] In an embodiment of the present disclosure, the lubricant is selected from the group consisting of sodium oleate, L-leucine, sodium stearyl fumarate and colloidal silicon dioxide.
[0173] In an embodiment of the present disclosure, the lubricant is water soluble or water miscible or water dispersible. Lubrication is an important step in the preparation of the composition of the present disclosure as it enhances the flow properties and prevents the sticking of the ingredients to the tablet punches during the manufacturing.
[0174] In the next step, the master blend or the milled blend or the lubricated mixture is compressed by exerting a force in the range of 5 tons to 25 tons at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain the controlled release, tablet composition.
[0175] In an embodiment of the present disclosure, the master blend or the milled blend or the lubricated mixture is compressed into tablets using a tablet press.
[0176] In an embodiment of the present disclosure, the tablet compression is multi-stage and multilayer.
[0177] During compression, the compression force, speed, and tablet thickness are monitored in realtime, to ensure consistent tablet quality.
[0178] In an embodiment of the present disclosure, the composition is in a shape selected from the group consisting of flat faced, circle, oval, triangle, square, rectangle, pentagon, hexagon, heptagon, octagon, cylindrical, hollow cylinder, convex, diamond and star.
[0179] The tablet shapes are designed to minimize contact between stacked tablets to reduce flavor cross-contamination, by limiting surface contact. Shapes like domed, beveled-edge, or ringshaped tablets also influence dissolution rate by altering the surface area exposed to water.
[0180] The so obtained controlled release, tablet composition is optionally coated at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a coated controlled release, tablet composition.
[0181] In an embodiment of the present disclosure, the coating is selected from the group consisting of sugar coating, film coating, enteric coating, controlled-release coating, functional coating, and opacified coating.
[0182] Coating protects the tablet composition and controls drug release profile of the composition. The coating is optimized to respond to conditions such as pH, temperature, and the like for precise, taigeted delivery of the active agents / other ingredients.
[0183] Coating of the controlled-release, tablet composition of the present disclosure is performed not only to facilitate manufacturing but also to serve as a protective barrier, helping to prevent accidental user contact with products containing extremely low or high pH.
[0184] The controlled release, tablet composition of the present disclosure is subjected to quality control testing prior to packaging and market release. In an embodiment of the present disclosure, the packaging is carried out at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 %.
[0185] The tablets are packed using packaging technologies that protect against moisture, light, and mechanical damage. In an embodiment of the present disclosure, the packaging comprises an in-built desiccant system to control moisture levels inside the package.
[0186] In an embodiment of the present disclosure, the package is made of a material selected from the group consisting of paper sachets with moisture barrier, polyethylene (PE), high-density polyethylene (HDPE), low-density polyethylene (LDPE), aluminium, glass and stainless steel. The packaging material is compatible with the Proof-of-Green technology for end-to- end impact mapping and circularity implementation.
[0187] The composition of the present disclosure is designed to prevent the pre-oxidation and hydrolysis of sensitive ingredients such as vitamin C and its derivatives, retinol, resveratrol, redensyl, niacinamide, salicylic acid, probiotics, glycolic acid, peptides, ceramides, ectoin, and the like. Unlike conventional compositions, the compositions of the present disclosure remain stable till they are dissolved in water, ensuring greater effectiveness and longer- lasting performance of the active agents.
[0188] The composition of the present disclosure is dissolved in water to obtain freshly activated products such as serums, perfumes, sunscreens, toners, or other personal care and hygiene applications with enhanced efficacy and user satisfaction compared to conventional preformulated products.
[0189] The composition of the present disclosure is capable of generating pre-foam for manual dishwashing, toilet cleaning and the like, eliminating the need for manual lathering. The composition of the present disclosure rinses faster than conventional gels, powders, and bars, reduces soap residue on dishes leading to enhanced cleaning efficiency and water saving.
[0190] The composition enables direct use on dry hands or skin for applications such as hand wash, body wash and the like by eliminating the need for pre-wetting and thus significantly reduces water usage, specifically during the pre-rinsing stage.
[0191] The composition of the present disclosure on dissolution produces lump-free solutions, dispersions or emulsions, ensuring smooth and clog free dispensing and proper product function due the controlled pre-processing steps used during the manufacturing of the composition.
[0192] The process of the present disclosure uses concentrated liquid fragrances or liquid active agents which form complexes with the carrier molecule. The concentrated fragrance or active agent is encapsulated within the carrier molecule leading to enhanced liquid-holding capacity, and improved ingredient distribution, particularly in fragrance-heavy or active-heavy compositions, resulting in clearer and more uniform solutions or emulsions upon tablet dissolution. The controlled pre-processing steps used during the manufacturing of the composition of the present disclosure produces a lump-free solution, dispersion or emulsion on dissolution ensuring smooth and clog free dispensing and proper product function.
[0193] The present disclosure provides a system, Proof-of-Green, for measuring and displaying environmental savings from using the disclosed compositions in personal, home, and fabric care. The system includes digital tracking using blockchain or QR codes, calculation of savings in plastic, paper, and fuel, a user interface for displaying savings and ensuring transparency, tracking of product circularity in FMCG, counterfeit prevention, and supply chain monitoring.
[0194] The composition of the present disclosure is in tablet form that offers compactness and suitability for multi-packs of the same product / application. This reduces the single-use plastic and paper by over 90% and delivers more than 20 times logistical efficiency, all trackable in real time via Proof-of-Green technology, enabling economically viable circularity in FMCG products.
[0195] A key aspect of the present disclosure is the superior dispensing compatibility of the controlled-release tablet, achieved by the use of hydroxypropyl-P-cyclodextrin (carrier molecule) and the specialized low-viscosity xanthan gum (rheology modifier), individually or in combination. Unlike conventional formulations that often clog foam pumps or mist sprayers due to viscosity modifiers or carrier molecules, the combination of the carrier molecule and the rheology modifier of the present disclosure ensures a clear, stable solution and consistent, clog -free dispensing, even after more than 500 actuations. On the other hand, conventional cyclodextrins and gums, especially at higher concentrations, caused significant clogging in under 10 actuations. This optimized combination hydroxypropyl-P-cyclodextrin (carrier molecule) and the specialized low-viscosity xanthan gum (rheology modifier) used in the composition of the present disclosure enhances product reliability, usability, and consumer satisfaction.
[0196] The foregoing description of the embodiments has been provided for purposes of illustration and is not intended to limit the scope of the present disclosure. Individual components of a particular embodiment are generally not limited to that particular embodiment, but, are interchangeable. Such variations are not to be regarded as a departure from the present disclosure, and all such modifications are considered to be within the scope of the present disclosure.
[0197] The present disclosure is further described in light of the following experiments which are set forth for illustration purpose only and not to be construed for limiting the scope of the disclosure. The following experiments can be scaled up to industrial / commercial scale and the results obtained can be extrapolated to industrial scale.
[0198] EXPERIMENTAL DETAILS The details of the Biological materials used in the present disclosure are provided below in Table-I:
[0199] Hydroxypropyl-P-cyclodextrin (HPBCD) having a molecular weight in the range of 1.2 kDa to 1.5 kDa; and molar substitution in the range of 3.0 to 4.5 was used.
[0200] Low viscosity xanthan gum having molecular weight in the range of 1.5 x 106to 2.5 x 106Daltons; transmittance in the range of 80 % to 98 % at 600 nm; viscosity in the range of 800 mPa.s to 1300 mPa s at 60 rpm; and viscosity ratio in the range of 1.02 to 1.60 at 3 rpm / 60 rpm was used. General process for preparing the controlled-release, tablet composition in accordance with the present disclosure
[0201] The controlled-release, tablet composition was prepared at a controlled condition of 20 °C and a relative humidity (RH) of 20 %.
[0202] Initially, all the ingredients were checked and sorted prior to starting the preparation process. If, liquid, volatile / unstable ingredients were used in the composition, they were blended with the carrier molecule(s) to obtain a pre-treated mixture. The pre-treated mixture was subjected to drying, if required, using one or a combination of spray drying, vacuum drying, freeze drying. Drying was carried at a temperature below the room temperature (-40 °C to 30 °C) to ensure that volatile ingredients were not degraded. The pre-treated mixture was then blended with other ingredients to obtain the master blend. If, liquid, non-volatile ingredients were used in the composition, they were blended with the carrier molecule(s) to obtain a pretreated mixture. The pre-treated mixture was subjected to drying, if required, using one or a combination of spray drying, and vacuum drying. Drying was carried at a temperature between 30 °C to 100 °C. The pre-treated mixture was then blended with other ingredients to obtain the master blend. The ingredients were blended at 20 °C and 20 % RH to obtain a master blend.
[0203] The master blend was optionally granulated at 20 °C and 20 % RH, followed by optional drying and milling to obtain a milled blend.
[0204] The master blend or the milled blend was then optionally lubricated at 20 °C and 20 % RH using a lubricant to obtain a lubricated mixture.
[0205] The master blend or the milled blend or the lubricated mixture was then compressed by exerting a force in the range of 5 tons to 25 tons at 20 °C and 20 % RH to obtain the controlled release, tablet composition of the present disclosure.
[0206] The specific amounts of the ingredients used for the preparation of the controlled release, tablet compositions of the present disclosure are provided in Experiments 1 to 17.
[0207] Experiment 1: Preparation of the controlled- release, tablet composition for use as an auto air freshener in accordance with the present disclosure
[0208] A composition for use as an air freshener was prepared using the ingredients as disclosed in Table- 1.
[0209] The controlled-release, tablet composition was prepared at a controlled condition of 20 °C and a relative humidity (RH) of 20 %.
[0210] Pre-treatment step:
[0211] A liquid blend was first prepared using HPBCD + C16-C18 Fatty alcohol + a portion (1 g) of the concentrated lemon grass fragrance + mandarin fragrance (2: 1) in a ratio of 1: 1:0.5 in 5 portions of water. This blend was then subjected to freeze drying to obtain a pretreated mixture in the form of freeze dried powder.
[0212] The freeze drying was carried out at a temperature of -40 °C to 30 °C to ensure that the volatile ingredients (fragrances) were not degraded.
[0213] Preparing the master blend:
[0214] The pre-treated mixture was then blended with the other ingredients in an octagonal blender to obtain a master blend. The remaining portion of the concentrated fragrance (lemon grass fragrance + mandarin fragrance (2: 1)) was added during the blending step.
[0215] The master blend was then compressed using a 12-ton tablet compression setup at 20 °C and 20 % RH to obtain the controlled release, tablet composition of the present disclosure.
[0216] 16.05 g of the composition (tablet) was dissolved in 300 ml of water to obtain an aerosol-free auto air freshener having a pH of 7. The tablet composition encapsulates cetyl stearyl alcohol and the fragrance within HPpCD in the form of a dual-guest encapsulation complex, enhancing fragrance stability and enabling controlled release. Upon dissolution, it generates an aerosol-free, CCE-driven mist that disperses fragrance efficiently, ensuring smooth, clog- free use in fine-mist sprayers, providing a clear improvement over conventional air fresheners.
[0217] Comparative evaluation of the air freshener of the present disclosure with marketed air freshener
[0218] The performance of the air freshener obtained in Experiment 1 of the present disclosure comprising HPpCD (carrier molecule) was compared with a marketed product devoid of HPpCD. The results obtained are summarized in Table- la.
[0219] The air freshener tablet (16.05 g) of the present disclosure and the marketed tablet were individually dissolved in 300 ml of water in standard mist sprayer bottles. All the solutions were tested for the following parameters and the results obtained are summarized in Table- la: dispensing efficiency was tested by actuating fine-mist spray dispensers continuously for 500 times to simulate extended consumer usage; fragrance bloom and aroma retention qualitatively was assessed in standard 200 sq. ft. test room, measured hourly by sensory evaluation panel over 24 hours; fragrance release assessed qualitatively by sensory perception of top notes (immediate) and base notes (over extended hours); and safety assessed by noting absence of solvents (verified through MSDS).
[0220] The air freshener of the present disclosure (Experiment 1) comprising HPpCD demonstrated improved fragrance delivery performance, with enhanced initial perception of the top notes, significantly higher fragrance retention specifically base notes, and increased fragrance load compared to the marketed product devoid of HPpCD. HPpCD enabled fragrance release in stages, wherein immediate top-note were released, followed by sustained base-note diffusion, resulting in overall sensory perception. The air freshener of the present disclosure exhibited minimal phase separation and uniform fragrance distribution, indicating strong physical stability and functional reliability. Further, the air freshener of the present disclosure is entirely water-based and solvent-free, mitigating risks associated with conventional solventbased air fresheners.
[0221] Experiment 2: Preparation of the controlled-release, tablet composition for use as a sprayable serum in accordance with the present disclosure
[0222] A composition for use as a fragrance-free sprayable full body serum was prepared using the ingredients as disclosed in Table-2.
[0223] All the ingredients after checking and sorting were directly compressed using a 7-ton tablet compression setup at 20 °C and 20 % RH to obtain the controlled release, tablet composition of the present disclosure.
[0224] 19.15 g of the composition (tablet) was dissolved in 50 ml of water to obtain vitamin C full body serum having a pH of 5.1. The obtained serum was used for application in ultra-fine mist spray dispenser.
[0225] The HPpCD in the composition of the present disclosure stabilized the active agent (vitamin C and niacinamide) and prevented oxidation and hydrolysis resulting in extended potency. The low viscosity xanthan gum ensured smooth, clog-free dispensing through fine foam pumps.
[0226] Comparative evaluation of the vitamin C serum of the present disclosure with a marketed vitamin C serum.
[0227] Consumer-perceived performance of a marketed vitamin C liquid serum (6 months postmanufacture) and a freshly constituted vitamin C tablet serum in accordance with the present disclosure were assessed for a one-month period. The tablet composition (containing derivatized Vitamin C) obtained in Experiment 2 was dissolved in 50 ml of potable water to obtain the vitamin C serum in accordance with the present disclosure. The tablet composition was dissolved in water immediately prior to first use. The marketed product containing derivatized Vitamin C liquid serum used was stored under standard conditions.
[0228] For the study, 10 female participants in the age group of 25 to 45 years and having different skin types were randomly selected. Each participant applied the composition of the present disclosure on one half of the face, and the marketed vitamin C product on the other half of the face. The study was carried out for a duration of 30 days. The observations were recorded on a weekly basis. The participants were instructed to dissolve one tablet (19.15 g) in 50 ml potable water till a clear solution was obtained post complete dissolution of the tablet. This solution was used for the duration of the study by each participant. Both, the serum prepared from the composition of the present disclosure and the marketed vitamin C serum with same concentration of vitamin C were directly applied on each half of the face by the participants. All the participants were instructed to apply 4 drops (~0.2 ml) of the serums evenly to cleansed facial skin, once daily (evening), following standardized skincare routines. All participants used both the products each time on each half of the face. The serums were evaluated on the following parameters and the observations are summarized in Table -2a:
[0229] • skin brightness: perceived increase in skin radiance and brightness.
[0230] • skin texture: smoothness, evenness, and refined appearance of skin texture.
[0231] • reduction in dark spots: visibility reduction of dark spots or pigmentation marks. • skin firmness: improvement in perceived skin elasticity and tightness.
[0232] • product stability: change in serum appearance, color, and texture over usage
[0233] • period.
[0234] • overall satisfaction: aggregate user satisfaction based on overall experience.
[0235] It is seen from Table-2a that the vitamin C serum of the present disclosure was capable of consistently providing a noticeable improvement in skin brightness and texture, reduction in dark spots, improved in skin firmness and skin elasticity, compared to the marketed serum. Further, the vitamin C serum of the present disclosure remained clear indicating no detectable oxidation during the study period. Whereas, the marketed vitamin C serum showed yellowing due to degradation of vitamin C over the 6 months of storage. It is well known that vitamin C is susceptible to oxidative degradation in aqueous solutions resulting in loss in potency. On the other hand, the tablet-based composition of the present disclosure maintained vitamin C in a stable dry form till use. The vitamin C present in the tablet composition of the present disclosure was activated upon dissolution in water, resulting in enhanced performance as compared to the marketed vitamin C serum.
[0236] Experiment 3: Preparation of the controlled-release, tablet composition for use as a disinfecting floor cleaner in accordance with the present disclosure A composition for use as a disinfecting floor cleaner was prepared using the ingredients as disclosed in Table-3.
[0237] Experiment 3 was carried out following a similar process as provided in Experiment 2.
[0238] 19.4 g of the composition (tablet) was dissolved in 10000 ml (10 L) of water to obtain a floor cleaner having a pH of 8.
[0239] The tablet composition encapsulates cetyl stearyl alcohol and the fragrance within HPpCD in the form of a dual-guest encapsulation complex, enhancing fragrance stability and enabling controlled release. The surfactants (cetyl stearyl alcohol and sodium alpha olefin sulfonate) used in the composition provided the cleaning action in the floor cleaner.
[0240] Comparative evaluation of the floor cleaner of the present disclosure with marketed floor cleaners
[0241] The performance of the floor cleaner of the present disclosure comprising HPpCD (carrier molecule) was compared with marketed products devoid of HPpCD. The results obtained are summarized in Table-3a.
[0242] The floor cleaner tablet of the present disclosure and the marketed tablet were individually dissolved in 10000 ml (10 L) of water in regular floor cleaning buckets. All the solutions were tested for the following parameters and the results obtained are summarized in Table-3a:
[0243] - visually, olfactorily and cleansing of pre-existing oil spills (each solution was applied evenly across standardised 100 sq. ft. tiled flooring);
[0244] - fragrance bloom immediately upon application;
[0245] - odour control assessed by sensory panel in test room post-cleaning;
[0246] - absence of harmful phenols (confirmed through MSDS review); and
[0247] - cleaning efficiency assessed visually for residue, cleanliness, and shine post-drying.
[0248] The solutions were classified “Pass” only if: o clear rapid dissolution achieved without sediment; o fragrance bloom and odour control maintained without phenolic odour; and o visually evident cleaning performance on the spill using a touch feel squeaky clean sensorial evaluation and shine without residue.
[0249] It is seen from Table-3a that the HPpCD-based floor cleaner tablet of the present disclosure demonstrated enhanced cleaning efficacy, fragrance delivery, and user safety as compared to the conventional compositions. The composition of the present disclosure dissolved completely within 3 minutes without any visible sediment, providing a quick and convenient solution.
[0250] Further, the composition of the present disclosure delivered strong fragrance bloom and long- lasting odour control without the use of harmful phenols. It effectively removed oil spills, leaving surfaces clean and residue-free. Thus, the composition of the present disclosure is a safer and more effective alternative to conventional phenol-based and tablet floor cleaners. Experiment 4: Preparation of the controlled-release, tablet composition for use as a foam spray toilet cleaner in accordance with the present disclosure
[0251] A composition for use as a foam spray toilet cleaner was prepared using the ingredients as disclosed in Table-4.
[0252] Experiment 4 was carried out following a similar process as provided in Experiment 2.
[0253] 17.35 g of the composition (tablet) was dissolved in 300 ml of water to obtain a foam spray toilet cleaner having a pH of 1.5. The surfactants (cetyl stearyl alcohol and sodium alpha olefin sulfonate) used in the composition provided the cleaning action in the toilet cleaner. Use of betaine HC1 makes it possible to achieve the extremely low pH of 1.5. Further, the combination of HPpCD and low viscosity xanthan gum helped in stabilizing the surfactant, high loading of fragrance, formation of clinging foam without clogging of the spray dispensers.
[0254] Comparative evaluation of the toilet cleaner of the present disclosure with marketed toilet cleaners
[0255] The performance of the toilet cleaner of the present disclosure comprising HPpCD (carrier molecule) low viscosity xanthan gum (rheology modifier) and betaine HC1 (acid component of the effervescent agent) was compared with marketed products comprising citric acid (acid component of the effervescent agent). The marketed products did not contain HPpCD and low viscosity xanthan gum. The results obtained are summarized in Table-4a.
[0256] The toilet cleaner tablet composition (17.35 g) of the present disclosure and the marketed tablets were individually dissolved in 300 ml of water and poured meanwhile the ready to use marketed toilet cleaner samples were used directly in standard toilet cleaning dispenser bottles. The tablet made solutions were dispensed using standard trigger foam pumps designed for toilet bowl cleaning. All the solutions were tested for the following parameters and the results obtained are summarized in Table -4a: effervescence was assessed by maintaining the solutions in the dispenser bottles for 2.5 hours (dissolution time (DT)); dispensing efficiency was tested by actuating trigger foam pumps continuously for 500 times to simulate extended consumer usage;
[0257] - pH of the solutions was measured using calibrated pH meter; foam cling was assessed visually after application in standard ceramic toilet bowl;
[0258] - vapour release was assessed by observing any pungent vapour emissions during product dispensing and application.
[0259] The solutions were classified “Pass” only if: • optimal pH of 1.5 was achieved for tough scale removal;
[0260] • no oozing or overflow from dispenser was observed;
[0261] • no blockage occurred during continuous actuations; and
[0262] • stable foam cling was maintained without release of pungent vapours.
[0263] It is seen from Table-4a that the toilet cleaner of the present disclosure comprising betaine HC1 and the combination of HPpCD with the low-viscosity xanthan gum of the present disclosure was able to achieve a pH of 1.5 and resulted in efficient scale removal in the toilet bowl. No oozing or overflow from the dispenser was observed for the toilet cleaner of the present disclosure. No blockage / clogging was observed during the continuous actuations and further stable foam cling was maintained without pungent vapours for the toilet cleaner of the present disclosure.
[0264] The use of betaine HC1 makes it possible to achieve the extremely low pH of 1.5 along with controlled fizzing that eliminates spilling, which cannot be achieved by using only citric acid. The use of HPpCD stabilized the high fragrance load and the specialized xanthan gum ensured clinging foam without clogging of the spray dispensers.
[0265] Experiment 5: Preparation of the controlled-release, tablet composition for use as a foam spray dishwash in accordance with the present disclosure
[0266] A composition for use as a foam spray dishwash was prepared using the ingredients disclosed in Table-5. Experiment 5 was carried out following a similar process as provided in Experiment 2.
[0267] 21. 1 g of the tablet composition obtained in Experiment 5 was dissolved in 300 ml of water to obtain a manual foam spray dishwash having a pH of 11.
[0268] The surfactants (cetyl stearyl alcohol and sodium alpha olefin sulfonate) used in the composition provided the cleaning action in the dishwash. The tablet composition used a strongly alkaline effervescent system to achieve a high pH (pH=ll). The combination of the specialized xanthan gum and the HPpCD-encapsulated fragrances ensured optimal foam consistency without clogging nozzles which was observed in conventional viscous alkaline cleaning solutions.
[0269] Comparative evaluation of the dishwash of the present disclosure with marketed dishwash
[0270] The performance of the dishwash of the present disclosure comprising HPpCD (carrier molecule) and low viscosity xanthan gum (rheology modifier) was compared with marketed products devoid of HPpCD and comprising regular xanthan gum. The results obtained are summarized in Table-5a. The composition (tablet, 21.1 g) of the present disclosure and the marketed tablet were individually dissolved in 300 ml of water and poured in standard dishwash dispensers. The solutions were dispensed using standard dispensers designed for dishwashing. All the solutions were tested for the following parameters and the results obtained are summarized in Table -5 a: dispensing efficiency was tested by actuating trigger foam pumps continuously for 300 times to simulate extended consumer usage;
[0271] - pH of the solutions was measured using calibrated pH meter; - foam cling and soap residue were assessed visually on standard glass and ceramic dishes, post-cleaning and rinsing;
[0272] - water required for rinsing; and
[0273] - plastic and packaging material used.
[0274] It is seen from Table-5a that the dishwashing composition of the present disclosure comprising HPpCD and the low-viscosity xanthan gum provided better results as compared to the conventional gel and bar-based products. The controlled effervescence and minimized spillage ensured user safety and convenience. The pH of 11 resulted in enhanced grease removal, while also exhibiting strong foam cling and residue-free cleaning without pump blockage. Further, the composition of the present disclosure in the form of a tablet significantly reduced water usage and plastic waste, offering advantages in both consumer performance and environmental impact, supporting its commercial viability. Experiment 6: Preparation of the controlled-release, tablet composition for use as a foaming handwash in accordance with the present disclosure
[0275] A composition for use as a foaming handwash was prepared using the ingredients disclosed in Table-6.
[0276] Experiment 6 was carried out following a similar process as provided in Experiment 2. 16.3 g of the composition (tablet) was dissolved in 500 ml of water to obtain a foaming handwash having a pH of 5.1 which was used in a wall mounted foaming handwash setup inside a high footfall office complex. The solution obtained after the complete dissolution of the tablet was a fully homogeneous solution having a low viscosity and did not require further stirring before use. The HPpCD in the composition stabilized the active agent (vitamin C) and prevented oxidation and hydrolysis resulting in extended potency and the low viscosity xanthan gum ensured smooth, clog -free dispensing through fine foam pumps.
[0277] Experiment 7: Preparation of the controlled-release, tablet composition for use as a probiotic body mist in accordance with the present disclosure
[0278] A composition of probiotic body mist for use in an ultra-fine mist sprayer was prepared using the ingredients as disclosed in Table-7.
[0279] Experiment 7 was carried out following a similar process as provided in Experiment 1. The Bacillus clausii spores in concentration of 1 x 108CFU m / L were first pre-blended and complexed with HPBCD to form inclusion complexes (pre-treated mixture). Separately, the fragrance was blended with the HPBCD to form a separate inclusion complex (pre-treated mixture). All the ingredients were then blended to obtain a master blend and then compressed to obtain the composition (tablet) of the present disclosure.
[0280] 12.55 g of the composition (tablet) was dissolved in 100 ml of water to obtain a probiotic mist body spray having a pH of 5.5.
[0281] The HPpCD stabilized the Bacillus clausii spores and resulted in enhanced potency and minimal log drop in the CFU when compared to conventional liquid product. Further, the solution was clear and had a low viscosity due to the use of the low viscosity xanthan gum ensuring a smooth and clog-free dispensing through fine foam pumps. Experiment 8: Preparation of the controlled-release, tablet composition for use as a foaming facewash in accordance with the present disclosure
[0282] A composition for use as a foaming facewash was prepared using the ingredients as disclosed in Table- 8.
[0283] Experiment 8 was carried out following a similar process as provided in Experiment 2.
[0284] 12.95 g of the composition (tablet) was dissolved in 150 ml of water to obtain a foaming facewash having a pH of 5.1.
[0285] The HPpCD in the composition stabilized the active agent (vitamin C) and prevented oxidation and hydrolysis resulting in extended potency and the low viscosity xanthan gum ensured smooth, clog -free dispensing through fine foam pumps.
[0286] Experiment 9: Preparation of the controlled-release, tablet composition for use as a toner spray in accordance with the present disclosure A composition for use as a toner spray was prepared using the ingredients as disclosed in Table- 9.
[0287] Experiment 9 was carried out following a similar process as provided in Experiment 2. 11.82 g of the composition (tablet) was dissolved in 150 ml of water to obtain a toner spray having a pH of 5.1.
[0288] The HPpCD in the composition stabilized the active agent (K Phyto peptide) and prevented its photo-oxidation. The low viscosity xanthan gum ensured smooth, clog-free dispensing through the sprayers. Experiment 10: Preparation of the controlled-release, tablet composition for use as a foaming bodywash in accordance with the present disclosure
[0289] A composition for use as a foaming bodywash was prepared using the ingredients as disclosed in Table- 10.
[0290] Experiment 10 was carried out following a similar process as provided in Experiment 2.
[0291] 19.9 g of the composition (tablet) was dissolved in 200 ml of water to obtain a foaming bodywash having a pH of 5.5.
[0292] The surfactants (olive oil glutamate and sodium alpha olefin sulfonate) used in the composition provided the cleansing action in the bodywash. The HPpCD in the composition stabilized the surfactants and prevented its oxidation and hydrolysis and also enabled high loading of the fragrance resulting in better exfoliation / cleaning and extended release of the fragrance. Further, a clear and low viscous solution was maintained due to the use of the low viscosity xanthan gum ensuring smooth and clog-free dispensing. The body wash was dispensed using the foam actuator of the present disclosure. The actuator featured internally contoured dual-channel dispersion nozzles that enable precise aeration during dispensing resulting in improved foam volume, creaminess and longevity.
[0293] Experiment 11: Preparation of the controlled- release, tablet composition for use as a shavefoam in accordance with the present disclosure A composition for use as a shavefoam was prepared using the ingredients as disclosed in Table- 11.
[0294] Experiment 11 was carried out following a similar process as provided in Experiment 2. 19.2 g of the composition (tablet) was dissolved in 150 ml of water to obtain a shavefoam having a pH of 5.1.
[0295] The use of HPBCD facilitated a high load of the fragrance along with the active agent (sodium salicylate) in the form of inclusion complex and helped in the prevention of oxidation and hydrolysis of the active agent. Further, the low viscosity xanthan gum provided a clear and low viscosity solution, ensuring a smooth and clog-free dispensing of the composition.
[0296] Experiment 12: Preparation of the controlled- release, tablet composition for use as a pet shampoo in accordance with the present disclosure A composition for use as a pet shampoo was prepared using the ingredients as disclosed in Table-12. The shampoo had a mild fragrance and the use of 3-(N-Butylacetamido)-propionic acid ethyl ester acted as an insect repellent. Experiment 12 was carried out following a similar process as provided in Experiment 2.
[0297] 21.95 g of the composition (tablet) was dissolved in 100 ml of water to obtain a petshampoo having a pH of 7.
[0298] The use of carrier molecule (HPBCD) in combination with the rheology modifier (low viscosity xanthan gum) facilitated a high load of the fragrance along with the active agent (3- (N-Butylacetamido)-propionic acid ethyl ester), helped in the prevention of oxidation and hydrolysis of the active agent and provided a clear and low viscosity solution, ensuring a smooth and clog-free dispensing of the composition.
[0299] Experiment 13: Comparative performance evaluation of the carrier molecule and rheology modifier used in the compositions of the present disclosure The performance evaluation of the carrier molecule (HPpCD) and the rheology modifier (low viscosity xanthan gum) used in the compositions of the present disclosure was carried out on the following parameters and the results obtained are summarized in Table-13:
[0300] 5 - the compositions were individually dissolved in potable water at a ratio of 1:5 to 1: 10; each solution was tested with four common dispenser types: foam pump (palm / fmger type), foam pump (trigger type), fine mist finger sprayer, and trigger mist sprayer; each pump or sprayer was actuated 500 times continuously to simulate consumer usage.
[0301] 10 - a test was classified as “Blocked” if dispensing significantly reduced or completely ceased due to blockage; and a test was classified as “Pass” only if consistent spray performance was maintained throughout all 500 actuations. It is seen from Table- 13 that the composition of the present disclosure comprising a combination of HPpCD with a molar substitution in the range of 3 to 4.5 (7* MS) and a low- viscosity xanthan gum consistently enabled reliable dispensing across all tested mechanisms, including foam and trigger sprayers. The other combinations, such as those using maltodextrin or P-cyclodextrin with the low viscosity xanthan gum, exhibited premature pump blockage (within 15 actuations) or failed to form effective inclusion complexes with volatile active agents, limiting their applicability. The combination of HPpCD and low- viscosity xanthan gum system ensured robust performance and compatibility.
[0302] Experiment 14: Comparative dispensing performance study of final solutions obtained by dissolution of tablet compositions with and without foam pump actuators
[0303] The dispensing performance of the solutions obtained by dissolution of tablet compositions with and without foam pump actuators was studied. The foam pump actuators in accordance with the present disclosure featured internally contoured dual -channel dispersion nozzles.
[0304] For the study, 18 female participants aged 20 to 45 years were randomly selected and divided into six groups. Each group received a solution prepared by dissolving a tablet composition (body wash, hand wash, or face wash) in a dispenser, either equipped with or without a foam actuator. The results of the evaluation are summarized in Table 14.
[0305] It is seen from Table- 14 that the foam pumps with actuators significantly enhanced the sensory experience of the product compared to when the actuator was not used. Compared to conventional nozzles, a significant improvement in foam volume, creaminess and longevity, was observed when foam pumps with actuators were used. The foam pump with actuator of the present disclosure was capable of delivering enhanced user experience and product differentiation in skin-care foaming applications.
[0306] TECHNICAL ADVANCEMENTS The present disclosure described herein above has several technical advantages including, but not limited to, the realization of a controlled-release, tablet composition that:
[0307] • maintains the active agents / other ingredients in an un-oxidized state till use to avoid its degradation;
[0308] • provides a broad pH range upon dissolution, making it suitable for various applications;
[0309] • provides precise dosage control for wide variety of applications;
[0310] • does not clog the foam or ultra-fine mist dispensers; and
[0311] • is environmentally sustainable, and a process for preparing a controlled-release, tablet composition that:
[0312] • uses pre-treatment steps to encapsulate / retain high amount of liquid volatile ingredients; and
[0313] • is easy, simple, environment-friendly, and cost-efficient.
[0314] The embodiments herein and the various features and advantageous details thereof are explained with reference to the non-limiting embodiments in the following description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of ways in which the embodiments herein may be practiced and to further enable those of skill in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein.
[0315] The foregoing description of the specific embodiments so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and / or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the embodiments as described herein.
[0316] Throughout this specification the word “comprise”, or variations such as “comprises” or “comprising”, will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps.
[0317] The use of the expression “at least” or “at least one” suggests the use of one or more elements or ingredients or quantities, as the use may be in the embodiment of the disclosure to achieve one or more of the desired objects or results.
[0318] Any discussion of documents, acts, materials, devices, articles or the like that has been included in this specification is solely for the purpose of providing a context for the disclosure. It is not to be taken as an admission that any or all of these matters form a part of the prior art base or were common general knowledge in the field relevant to the disclosure as it existed anywhere before the priority date of this application. The numerical values mentioned for the various physical parameters, dimensions or quantities are only approximations and it is envisaged that the values higher / lower than the numerical values assigned to the parameters, dimensions or quantities fall within the scope of the disclosure, unless there is a statement in the specification specific to the contrary.
[0319] While considerable emphasis has been placed herein on the components and component parts of the preferred embodiments, it will be appreciated that many embodiments can be made and that many changes can be made in the preferred embodiments without departing from the principles of the disclosure. These and other changes in the preferred embodiment as well as other embodiments of the disclosure will be apparent to those skilled in the art from the disclosure herein, whereby it is to be distinctly understood that the foregoing descriptive matter is to be interpreted merely as illustrative of the disclosure and not as a limitation.
Claims
1. CLAIMS:
1. A controlled-release, tablet composition comprising: a. an effervescent agent comprising an acid component and a base component; b. at least one water soluble active agent selected from the group consisting of a vitamin, a provitamin, a cofactor complex, an enzyme, a probiotic, a postbiotic, a microbial culture, a botanical extract, an algal extract, a marine extract, a fungal extract, a microbial extract, a peptide, a mineral extract, an antimicrobial agent, an anti-inflammatory agent, a bleaching agent, a whitening agent, a conditioning agent, an optical brightener, a cleaning agent, a disinfectant, an insect repellent, a colour-modifying agent, a cleansing agent, a therapeutic agent, a tan enhancer and a sun care agent; c. a carrier molecule; d. a rheology modifier; and e. at least one water soluble excipient selected from the group consisting of a humectant, a moisturizing agent, an emulsifier, a pH modifier, a buffering agent, an antioxidant, a stabilizer, a sequestering agent, a solubilizer, a dispersant, a wetting agent, a surfactant, a viscosity modifier, a thickening agent, a foaming agent, an anti-foaming agent, a binder, a disintegrant, chelating agent, a lubricant, a flow aid, an anti-caking agent, a plasticizer, a film former, a bulking agent, a filler, a colorant, an opacifier, a fragrance, a preservative, a UV absorber and a corrosion inhibitor.
2. The composition as claimed in claim 1, wherein said composition comprises• at least one water soluble active agent or water miscible active agent or water dispersible active agent; and• at least one water soluble excipient or water miscible excipient or water dispersible excipient.
3. The composition as claimed in claim 1, wherein• said effervescent agent is present in an amount in the range of 5 mass% to 75 mass%;• said active agent is present in an amount in the range of 0.1 mass% to 80 mass%;• said carrier molecule is present in an amount in the range of 0 mass% to 50 mass%;• said rheology modifier is present in an amount in the range of 0 mass% to 25 mass%; and• said excipient is present in an amount in the range of 0.1 mass% to 70 mass%, wherein said mass% of each ingredient is with respect to the total mass of said composition.
4. The composition as claimed in claim 1, wherein• said effervescent agent is present in an amount in the range of 15 mass% to 50 mass%;• said active agent is present in an amount in the range of 2 mass% to 55 mass%;• said carrier molecule is present in an amount in the range of 1 mass% to 40 mass%;• said rheology modifier is present in an amount in the range of 0.1 mass% to 5 mass%; and• said excipient is present in an amount in the range of 15 mass% to 70 mass%, wherein said mass% of each ingredient is with respect to the total mass of said composition.
5. The composition as claimed in claim 1, wherein a molar ratio of said acid component to said base component in said effervescent agent is in the range of 1: 10 to 10: 1.
6. The composition as claimed in claim 1 comprising a. an effervescent agent comprising an acid component and a base component; b. at least one active agent selected from the group consisting of a disinfectant, a vitamin, an insect repellent, an anti-inflammatory agent, a peptide, an enzyme, an antimicrobial agent and a probiotic, wherein said active agent is water soluble or water miscible or water dispersible; c. a carrier molecule; d. a rheology modifier; and e. at least one excipient selected from the group consisting of a surfactant, a preservative, a solubilizer, a chelating agent, a filler, a humectant, a fragrance and a foaming agent, wherein said excipient is water soluble or water miscible or water dispersible.
7. The composition as claimed in claim 6, wherein• said acid component is selected from the group consisting of betaine hydrochloride, citric acid, tartaric acid, malic acid, fumaric acid, lactic acid, adipic acid, maleic acid, glycolic acid, gluconic acid, acetic acid, formic acid, benzoic acid, sorbic acid, oxalic acid, salicylic acid, mandelic acid, phosphoric acid, sulphamic acid, hydrochloric acid, nitric acid, boric acid, carbonic acid and a combination thereof; and• said base component is selected from the group consisting of sodium carbonate, sodium bicarbonate, calcium carbonate, potassium bicarbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, sodium metasilicate, sodium hydroxide, a percarbonate, a perborate, a borate, an amino-alcohol base and a combination thereof.
8. The composition as claimed in claim 6, wherein• said disinfectant is selected from the group consisting of n-alkyl dimethyl benzyl ammonium chloride, n-alkyl dimethyl ethylbenzyl ammonium chloride, chloroxylenol, o-phenylphenol, cetylpyridinium chloride (CPC), benzethonium chloride, chlorhexidine gluconate, sodium hypochlorite, hydrogen peroxide, ethanol, isopropyl alcohol, povidone-iodine, thymol, silver nanoparticles, pine oil disinfectant, hypochlorous acid, glutaraldehyde and a combination thereof;• said vitamin is selected from the group consisting of vitamin A, vitamin Bl, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, vitamin B12, vitamin C, vitamin D, vitamin D2, vitamin D3, vitamin E, vitamin K, vitamin K2, vitamin K3, retinol, retinyl palmitate, thiamine HC1, riboflavin-5- phosphate, niacinamide, calcium pantothenate, pyridoxine-HCl, biotin, folic acid, methylcobalamin, sodium ascorbyl phosphate, ergocalciferol, cholecalciferol, tocopheryl acetate, phylloquinone, menaquinone-7 and a combination thereof;• said insect repellent is selected from the group consisting of 3-(N-butyl acetamido)- propionic acid ethyl ester, pyrethrin, permethrin, piperonyl butoxide, N,N-diethyl-meta-toluamide, icaridin, citronella oil, p-menthane-3,8-diol, geraniol, soybean oil, catnip oil, and a combination thereof;• said anti-inflammatory agent is selected from the group consisting of sodium salicylate, methyl salicylate, beta hydroxy acid, allantoin, hydrocortisone and a combination thereof;• said peptide is selected from the group consisting of acetyl hexa peptide-8-amide, a phyto peptide, an acetyl peptide, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, a copper peptide, dipeptide-2, palmitoyl tripeptide-5, palmitoyl oligopeptide, acetyl dipeptide- 1 cetyl ester, a collagen peptide, an elastin peptide, a silk peptide, a wheat peptide, a soy peptide, a rice peptide, a keratin peptide, a phytocannabinoid peptide, a seaweed peptide, a phytocomplex peptide, an antimicrobial peptide, tripeptide-1, hexapeptide-9, pentapeptide- 18 and a combination thereof;• said enzyme is selected from the group consisting of protease, amylase, lipase, cellulase, mannanase, pectinase, keratinase, lactoperoxidase, superoxide dismutase, laccase, urease, phytase, papain, bromelain and a combination thereof; and• said antimicrobial agent is selected from the group consisting of tea tree oil, thyme oil, eucalyptus oil, polylysine and a combination thereof;• said probiotic is a bacteria or a yeast and is selected from the group consisting of Bacillus, Lactobacillus, Bifidobacterium, Pediococcus, Streptococcus thermophilus, Enterococcus faecium, Propionibacterium, Clostridium butyricum, Kluyveromyces, Debaryomyces, Saccharomyces and a combination thereof.
9. The composition as claimed in claim 6, wherein said carrier molecule is selected from the group consisting of maltodextrin, amylodextrin, a,P-dextrin, cyclodextrin, zeolite, talc, starch and their derivatives.
10. The composition as claimed in claim 6, wherein said rheology modifier is selected from the group consisting of xanthan gum, carrageenan, guar gum, sclerotium gum and an alginate.
11. The composition as claimed in claim 6, wherein said surfactant is selected from the group consisting of an anionic surfactant, a cationic surfactant, a non-ionic surfactant, an amphoteric surfactant and a combination thereof.
12. The composition as claimed in claim 11, whereinsaid anionic surfactant is selected from the group consisting of a sulfate, a sulfonate, a carboxylate, a phosphate, an isethionate, a glutamate, a sulfoacetate, an a-olefm sulfonate, an amino-acid-derived anionic surfactant and their derivatives; said cationic surfactant is selected from the group consisting of a quaternary ammonium surfactant, an esterquat, a poly(amino-acid) cationic surfactant and their derivatives; said non-ionic surfactant is selected from the group consisting of an alkyl polyglucoside, a fatty-alcohol ethoxylate, a polysorbate, a methyl-ester ethoxylate and their derivatives; and said amphoteric surfactant is selected from the group consisting of a sultaine, a sarcosinate, an imidazoline, an amine-oxide surfactant and their derivatives.
13. The composition as claimed in claim 6, wherein said preservative is selected from the group consisting of sodium benzoate, potassium sorbate, polylysin, carvacrol, phenoxyethanol, ethylhexyl glycerin, caprylyl glycol, sodium levulinate, sodium anisate, grapefruit seed extract, rosemary extract, neem oil and a combination thereof.
14. The composition as claimed in claim 6, wherein said solubilizer is selected from the group consisting of polyethylene glycol, a polysorbate, capryl glucoside, caprylyl glucoside, lauryl glucoside, blend of polypropylene glycol (PPG)-26-Buteth-26; polyethylene glycol (PEG)-40 hydrogenated castor oil; water, blend of caprylyl / capryl glucoside; water; diisopropyl adipate; triethyl citrate, blend of decyl glucoside; water; diisopropyl adipate; triethyl citrate; citric acid and a combination thereof.
15. The composition as claimed in claim 5, wherein said chelating agent is selected from the group consisting of trisodium salt of methylglycinediacetic acid, ethylenediaminetetraacetic acid (EDTA), microencapsulated EDTA and its derivatives, glutamic acid diacetate, diethylenetriaminepentaacetic acid, 1- hydroxyethylidene-l,l-diphosphonic acid, aminotrimethylenephosphonic acid, sodium gluconate, calcium gluconate, glutamic acid N,N-diacetic acid, polyaminocarboxylic acids, nitrilotriacetic acid, iminodisuccinic acid and ethylenediamine disuccinic acid, polyaspartic acid and a combination thereof.
16. The composition as claimed in claim 6, wherein said filler is selected from the group consisting of precipitated silica, modified silica, sodium chloride and a combination thereof.
17. The composition as claimed in claim 6, wherein said humectant and said moisturizing agent are independently selected from the group consisting of Aloe vera powder, glycerin, a seaweed extract, sorbitol, xylitol, ectoin, trehalose, glycotoin, a polyquatemium, a hyaluronic acid polymer derivative, urea, a ceramide and a combination thereof.
18. The composition as claimed in claim 6, wherein said fragrance is selected from the group consisting of floral fragrance, citrus fragrance, aquatic fragrance, herbal fragrance, woody fragrance, fruity fragrance, spicy fragrance, gourmand fragrance, green fragrance, oriental fragrance and a combination thereof.
19. The composition as claimed in claim 6, wherein said foaming agent is selected from thegroup consisting of sodium stearate, sodium palmitate, sodium lauryl sulfate, sodium laureth sulfate, sodium lauroyl sarcosinate, sodium cocoyl glutamate, sodium alpha olefin sulfonate, sodium cocoyl isethionate, disodium cocoyl glutamate, cocamidopropyl betaine, soapnut extract, yucca extract, quillaja extract, polymeric foaming agent, blend of polyethylene glycol (PEG) and PEG- 12 dimethicone and a combination thereof.
20. The composition as claimed in claim 1, wherein said composition is dissolved in water in a predetermined mass ratio to obtain a product having a pH in the range of 0.5 to 14, for use as a consumer care product.
21. The composition as claimed in claim 20, wherein said predetermined mass ratio of said composition to water is in the range of 1 : 1.5 to 1: 1000.
22. The composition as claimed in claim 1, wherein said composition is contained in a package comprising an integrated blockchain-linked or an QR code technology ("Proof- of-Green"), configured to enable real-time tracking and transparent display of environmental sustainability metrics selected from the group consisting of reduction in plastic waste, water usage, fuel consumption, and overall carbon footprint.
23. A kit comprising said controlled release, tablet composition as claimed in claim 1, a dispenser device and a set of instructions for use thereof.
24. A process for preparing a controlled release, tablet composition, said process comprising the following steps: i. blending predetermined amounts of ingredients at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a master blend; ii. optionally, granulating said master blend by using a binder at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 %, followed by drying and milling to obtain a milled blend; iii. optionally, lubricating said master blend or said milled blend by using a lubricant at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain a lubricated mixture; and iv. compressing said master blend or said milled blend or said lubricated mixture by exerting a force in the range of 5 tons to 25 tons at a temperature in the range of 15 °C to 25 °C and at a relative humidity in the range of 15 % to 25 % to obtain said controlled release, tablet composition, in the form of a tablet.
25. The process as claimed in claim 24, wherein said ingredients are selected from the group consisting of an effervescent agent comprising an acid component and a base component, a carrier molecule, a rheology modifier, an active agent and at least one excipient and wherein said ingredients are in a form selected from powder, granule, paste, gel, liquid and emulsion.
26. The process as claimed in claim 24, comprises coating said controlled release, tablet composition to obtain a coated controlled release, tablet composition.
27. The process as claimed in claim 24, wherein said is binder selected from the group consisting of croscarmellose sodium, low-substituted hydroxypropyl cellulose, polyvinylpyrrolidone and hydroxypropyl cellulose; and said lubricant in step (iii) isselected from sodium oleate, L-leucine, sodium stearyl fumarate and colloidal silicon dioxide.
28. The process as claimed in claim 24, wherein said process comprises a pre-treatment step prior to step (i), said pre-treatment comprising blending said ingredients with a carrier molecule, followed by drying at a temperature in the range of -40 °C to 100 °C to obtain a pre -treated mixture.
29. The process as claimed in claim 28, wherein said drying is carried out by a method selected from the group consisting of spray drying, vacuum drying and freeze drying.
Citation Information
Patent Citations
Effervescent medicinal preparation
CN101987089A
Effervescent tablet capable of fast supplementing energy, and preparation method of effervescent tablet
CN103689747A
Effervescent tablet containing sapropterin dihydrochloride
CN104257623A
Wudalianchi dryopteris fragrans mineral spring effervescent tablet and preparation method thereof
CN104758215A
Antibacterial fabric cleaning effervescent tablet and preparation method thereof
CN109234089A